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1. General examination of the abdomen

Author

Gerhardus, M. J. T., Claessen, R. J. M., Valke, L. L. F. G., Duitscher-Fransen, K., Moll van Charante, E. P., de Jongh MD, T.O.H., editor, Jongen-Hermus MSc, F.J., editor, Damen MD PhD, J., editor, Daelmans MD PhD, H.E.M., editor, Franssen MD PhD, R., editor, de Klerk-van der Wiel MSc, I., editor, Pieterse MD, A.D., editor, Schouwenberg MD PhD, B.J.J.W., editor, and Schuring MD, F., editor

Published
2023
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2. The groin

Author

Valke, L. L. F. G., Gerhardus, M. J. T., Claessen, R. J. M., Duitscher-Fransen, K., van Charante, E. P. Moll, de Jongh MD, T.O.H., editor, Jongen-Hermus MSc, F.J., editor, Damen MD PhD, J., editor, Daelmans MD PhD, H.E.M., editor, Franssen MD PhD, R., editor, de Klerk-van der Wiel MSc, I., editor, Pieterse MD, A.D., editor, Schouwenberg MD PhD, B.J.J.W., editor, and Schuring MD, F., editor

Published
2023
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3. The anus and the rectum

Author

Valke, L. L. F. G., Claessen, R. J. M., Gerhardus, M. J. T., Duitscher-Fransen, K., van Charante, E. P. Moll, de Jongh MD, T.O.H., editor, Jongen-Hermus MSc, F.J., editor, Damen MD PhD, J., editor, Daelmans MD PhD, H.E.M., editor, Franssen MD PhD, R., editor, de Klerk-van der Wiel MSc, I., editor, Pieterse MD, A.D., editor, Schouwenberg MD PhD, B.J.J.W., editor, and Schuring MD, F., editor

Published
2023
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4. The anatomy of the abdomen and abdominal organs

Author

Valke, L. L. F. G., Gerhardus, M. J. T., Claessen, R. J. M., Duitscher-Fransen, K., van Charante, E. P. Moll, de Jongh MD, T.O.H., editor, Jongen-Hermus MSc, F.J., editor, Damen MD PhD, J., editor, Daelmans MD PhD, H.E.M., editor, Franssen MD PhD, R., editor, de Klerk-van der Wiel MSc, I., editor, Pieterse MD, A.D., editor, Schouwenberg MD PhD, B.J.J.W., editor, and Schuring MD, F., editor

Published
2023
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5. The abdominal examination on indication

Author

Claessen, R. J. M., Valke, L. L. F. G., Gerhardus, M. J. T., Duitscher-Fransen, K., van Charante, E. P. Moll, de Jongh MD, T.O.H., editor, Jongen-Hermus MSc, F.J., editor, Damen MD PhD, J., editor, Daelmans MD PhD, H.E.M., editor, Franssen MD PhD, R., editor, de Klerk-van der Wiel MSc, I., editor, Pieterse MD, A.D., editor, Schouwenberg MD PhD, B.J.J.W., editor, and Schuring MD, F., editor

Published
2023
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6. Prospects for Fundamental Physics with LISA

Author

Barausse, Enrico, Berti, Emanuele, Hertog, Thomas, Hughes, Scott A., Jetzer, Philippe, Pani, Paolo, Sotiriou, Thomas P., Tamanini, Nicola, Witek, Helvi, Yagi, Kent, Yunes, Nicolas, Abdelsalhin, T., Achucarro, A., Aelst, K. V., Afshordi, N., Akcay, S., Annulli, L., Arun, K. G., Ayuso, I., Baibhav, V., Baker, T., Bantilan, H., Barreiro, T., Barrera-Hinojosa, C., Bartolo, N., Baumann, D., Belgacem, E., Bellini, E., Bellomo, N., Ben-Dayan, I., Bena, I., Benkel, R., Bergshoefs, E., Bernard, L., Bernuzzi, S., Bertacca, D., Besancon, M., Beutler, F., Beyer, F., Bhagwat, S., Bicak, J., Biondini, S., Bize, S., Blas, D., Boehmer, C., Boller, K., Bonga, B., Bonvin, C., Bosso, P., Bozzola, G., Brax, P., Breitbach, M., Brito, R., Bruni, M., Brügmann, B., Bulten, H., Buonanno, A., Burke, A. O., Burko, L. M., Burrage, C., Cabral, F., Calcagni, G., Caprini, C., Cárdenas-Avendaño, A., Celoria, M., Chatziioannou, K., Chernoff, D., Clough, K., Coates, A., Comelli, D., Compère, G., Croon, D., Cruces, D., Cusin, G., Dalang, C., Danielsson, U., Das, S., Datta, S., de Boer, J., De Luca, V., De Rham, C., Desjacques, V., Destounis, K., Di Filippo, F., Dima, A., Dimastrogiovanni, E., Dolan, S., Doneva, D., Duque, F., Durrer, R., East, W., Easther, R., Elley, M., Ellis, J. R., Emparan, R., Ezquiaga, J. M., Fairbairn, M., Fairhurst, S., Farmer, H. F., Fasiello, M. R., Ferrari, V., Ferreira, P. G., Ficarra, G., Figueras, P., Fisenko, S., Foffa, S., Franchini, N., Franciolini, G., Fransen, K., Frauendiener, J., Frusciante, N., Fujita, R., Gair, J., Ganz, A., Garcia, P., Garcia-Bellido, J., Garriga, J., Geiger, R., Geng, C., Gergely, L. Á., Germani, C., Gerosa, D., Giddings, S. B., Gourgoulhon, E., Grandclement, P., Graziani, L., Gualtieri, L., Haggard, D., Haino, S., Halburd, R., Han, W. -B., Hawken, A. J., Hees, A., Heng, I. S., Hennig, J., Herdeiro, C., Hervik, S., Holten, J. v., Hoyle, C. J. D., Hu, Y., Hull, M., Ikeda, T., Isi, M., Jenkins, A., Julié, F., Kajfasz, E., Kalaghatgi, C., Kaloper, N., Kamionkowski, M., Karas, V., Kastha, S., Keresztes, Z., Kidder, L., Kimpson, T., Klein, A., Klioner, S., Kokkotas, K., Kolesova, H., Kolkowitz, S., Kopp, J., Koyama, K., Krishnendu, N. V., Kroon, J. A. V., Kunz, M., Lahav, O., Landragin, A., Lang, R. N., Poncin-Lafitte, C. Le, Lemos, J., Li, B., Liberati, S., Liguori, M., Lin, F., Liu, G., Lobo, F. S. N., Loll, R., Lombriser, L., Lovelace, G., Macedo, R. P., Madge, E., Maggio, E., Maggiore, M., Marassi, S., Marcoccia, P., Markakis, C., Martens, W., Martinovic, K., Martins, C. J. A. P., Maselli, A., Mastrogiovanni, S., Matarrese, S., Matas, A., Mavromatos, N. E., Mazumdar, A., Meerburg, P. D., Megias, E., Miller, J., Mimoso, J. P., Mittnacht, L., Montero, M. M., Moore, B., Martin-Moruno, P., Musco, I., Nakano, H., Nampalliwar, S., Nardini, G., Nielsen, A., Novák, J., Nunes, N. J., Okounkova, M., Oliveri, R., Oppizzi, F., Orlando, G., Oshita, N., Pappas, G., Paschalidis, V., Peiris, H., Peloso, M., Perkins, S., Pettorino, V., Pikovski, I., Pilo, L., Podolsky, J., Pontzen, A., Prabhat, S., Pratten, G., Prokopec, T., Prouza, M., Qi, H., Raccanelli, A., Rajantie, A., Randall, L., Raposo, G., Raymond, V., Renaux-Petel, S., Ricciardone, A., Riotto, A., Robson, T., Roest, D., Rollo, R., Rosofsky, S., Ruan, J. J., Rubiera-García, D., Ruiz, M., Rusu, M., Sabatie, F., Sago, N., Sakellariadou, M., Saltas, I. D., Sberna, L., Sathyaprakash, B., Scheel, M., Schmidt, P., Schutz, B., Schwaller, P., Shao, L., Shapiro, S. L., Shoemaker, D., Silva, A. d., Simpson, C., Sopuerta, C. F., Spallicci, A., Stefanek, B. A., Stein, L., Stergioulas, N., Stott, M., Sutton, P., Svarc, R., Tagoshi, H., Tahamtan, T., Takeda, H., Tanaka, T., Tantilian, G., Tasinato, G., Tattersall, O., Teukolsky, S., Tiec, A. L., Theureau, G., Trodden, M., Tolley, A., Toubiana, A., Traykova, D., Tsokaros, A., Unal, C., Unnikrishnan, C. S., Vagenas, E. C., Valageas, P., Vallisneri, M., Brand, J. Van den, Broeck, C. Van den, van de Meent, M., Vanhove, P., Varma, V., Veitch, J., Vercnocke, B., Verde, L., Vernieri, D., Vernizzi, F., Vicente, R., Vidotto, F., Visser, M., Vlah, Z., Vretinaris, S., Völkel, S., Wang, Q., Wang, Yu-Tong, Werner, M. C., Westernacher, J., Weygaert, R. v. d., Wiltshire, D., Wiseman, T., Wolf, P., Wu, K., Yamada, K., Yang, H., Yi, L., Yue, X., Yvon, D., Zilhão, M., Zimmerman, A., and Zumalacarregui, M.

Subjects
General Relativity and Quantum Cosmology
Abstract

In this paper, which is of programmatic rather than quantitative nature, we aim to further delineate and sharpen the future potential of the LISA mission in the area of fundamental physics. Given the very broad range of topics that might be relevant to LISA, we present here a sample of what we view as particularly promising directions, based in part on the current research interests of the LISA scientific community in the area of fundamental physics. We organize these directions through a "science-first" approach that allows us to classify how LISA data can inform theoretical physics in a variety of areas. For each of these theoretical physics classes, we identify the sources that are currently expected to provide the principal contribution to our knowledge, and the areas that need further development. The classification presented here should not be thought of as cast in stone, but rather as a fluid framework that is amenable to change with the flow of new insights in theoretical physics., Comment: 22 pages, 1 figure, to appear in General Relativity and Gravitation

Published
2020
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7. De anatomie van de buik en buikorganen

Author

Valke, L. L. F. G., Gerhardus, M. J. T., Claessen, R. J. M., Duitscher-Fransen, K., Moll van Charante, E. P., de Jongh, T.O.H., editor, Jongen-Hermus, F.J., editor, Damen, J., editor, Daelmans, H.E.M., editor, Franssen, R., editor, de Klerk-van der Wiel, I., editor, Pieterse, A.D., editor, Schouwenberg, B.J.J.W., editor, and Schuring, F., editor

Published
2022
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8. De anus en het rectum

Author

Valke, L. L. F. G., Claessen, R. J. M., Gerhardus, M. J. T., Duitscher-Fransen, K., Moll van Charante, E. P., de Jongh, T.O.H., editor, Jongen-Hermus, F.J., editor, Damen, J., editor, Daelmans, H.E.M., editor, Franssen, R., editor, de Klerk-van der Wiel, I., editor, Pieterse, A.D., editor, Schouwenberg, B.J.J.W., editor, and Schuring, F., editor

Published
2022
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9. Het buikonderzoek op indicatie

Author

Claessen, R. J. M., Valke, L. L. F. G., Gerhardus, M. J. T., Duitscher-Fransen, K., Moll van Charante, E. P., de Jongh, T.O.H., editor, Jongen-Hermus, F.J., editor, Damen, J., editor, Daelmans, H.E.M., editor, Franssen, R., editor, de Klerk-van der Wiel, I., editor, Pieterse, A.D., editor, Schouwenberg, B.J.J.W., editor, and Schuring, F., editor

Published
2022
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10. De liezen

Author

Valke, L. L. F. G., Gerhardus, M. J. T., Claessen, R. J. M., Duitscher-Fransen, K., Moll van Charante, E. P., de Jongh, T.O.H., editor, Jongen-Hermus, F.J., editor, Damen, J., editor, Daelmans, H.E.M., editor, Franssen, R., editor, de Klerk-van der Wiel, I., editor, Pieterse, A.D., editor, Schouwenberg, B.J.J.W., editor, and Schuring, F., editor

Published
2022
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11. Het oriënterend buikonderzoek

Author

Gerhardus, M. J. T., Claessen, R. J. M., Valke, L. L. F. G., Duitscher-Fransen, K., Moll van Charante, E. P., de Jongh, T.O.H., editor, Jongen-Hermus, F.J., editor, Damen, J., editor, Daelmans, H.E.M., editor, Franssen, R., editor, de Klerk-van der Wiel, I., editor, Pieterse, A.D., editor, Schouwenberg, B.J.J.W., editor, and Schuring, F., editor

Published
2022
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19. Werkwijze en eerste resultaten van multidisciplinaire afbouwpoli anti-depressiva

Author

Dozeman, E., van der Lande, H. J., Bet, P. M., Fransen, K., Jager, I., Jonker, J., Philippo, E., Reisman-Dolman, J., van Schaik, D. J. F., Scholten, W., van de Velde, I., Verheijen, V., van der Wart, M., van Zon, M., Batelaan, N., Vinkers, C. H., Psychiatry, APH - Mental Health, Clinical pharmacology and pharmacy, APH - Personalized Medicine, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, and Anatomy and neurosciences

Abstract

BACKGROUND: Discontinuation of antidepressant medication can be difficult due to withdrawal symptoms and relapse risk. Scientific evidence on the questions of who, when, and how to stop antidepressants is limited. In Amsterdam a multidisciplinary outpatient clinic was started to provide advice and guidance. AIM: To substantiate the design of the clinic. Central questions relate to knowing which patients are referred, the background of their request, and their experiences with the outpatient clinic. METHOD: The first 51 patients of the clinic were described on the basis of file research, in addition a survey was conducted into patient experiences. RESULTS: Half of the patients (55%) actually started discontinuation, 39% were advised not to do so (yet). Patients at the clinic had used antidepressants for an average of 10 years, and 76% had previously attempted to stop. 21% had now successfully stopped and 25% were satisfied with a lower dose. One patient relapsed during tapering. CONCLUSION: So far, patients with long-term antidepressant use and multiple quit attempts have been referred. Our experiences are aimed at helping individual patients but can also result in more knowledge about who can stop at what moment, and how this should be done.

Published
2022

23. Effect of Early Surgery vs Endoscopy-First Approach on Pain in Patients With Chronic Pancreatitis The ESCAPE Randomized Clinical Trial

Author

Issa, Y., Kempeneers, M.A., Bruno, M.J., Fockens, P., Poley, J.W., Ali, U.A., Bollen, T.L., Busch, O.R., Dejong, C.H., Duijvendijk, P. van, Dullemen, H.M. van, Eijck, C.H. van, Goor, H. van, Hadithi, M., Haveman, J.W., Keulemans, Y., Nieuwenhuijs, V.B., Poen, A.C., Rauws, E.A., Tan, A.C., Thijs, W., Timmer, R., Witteman, B.J., Besselink, M.G., Hooft, J.E. van, Santvoort, H.C. van, Dijkgraaf, M.G., Boermeester, M.A., Honkoop, P., Thijssen, A.Y., Kooistra, T., Balkema, S., Bekkali, N., Boparai, K.S., Kager, L.M., Kloek, J.J., Takkenberg, R.B., Gouma, D.J., Gulik, T.M. van, Bemelman, W.A., Zwinderman, A.H., Bodelier, A.G.L., Seerden, T.C.J., Enckevort, C. van, Gils, N. van, Schoon, E., Vogelaar, L., Vries, R.S. de, Voorburg, A.M., Heisterkamp, J., Bezemer, G., Braat, H., Didden, P., Farahani, N., Flink, H.J., Koch, A.D., Postma, C., Putten, P.G. van, Reijnders, J.G.P., Roomer, R., Wiersema, U., Homans, G.L., Mares, W.G.N., Meiland, R., Erkelens, G.W., Maanen, H. van, Muller, G., Geenen, E. van, Perk, L.E., Raaf, J. de, Fransen, K., Hoedemaker, R., Meijssen, M.A.C., Hergelink, D.O., Munster, I.P. van, Romkes, T.E.H., Braat, A.E., Schaapherder, A.F.M., Kubben, F.J.G.M., Hoge, C., Masclee, A., Stassen, L.P.S., Brink, M.A., Vlerken, L. van, Kolkman, J.J., Venneman, N.G., Houdijk, A.P.J., Spek, B. van der, Jansen, J.M., The, O., Gerhards, M.F., Gooszen, H.G., Wilder-Smith, O., Hoekstra, J., Josemanders, D.F.G.M., Spanier, B.W.M., Boer, S.Y. de, Vries, E. de, Al-toma, A., Ramshorst, B. van, Weusten, B.L.A.M., Boerma, D., Bijlsma, A.R., Festen, E.A.M., Kerkhof, I., Kleibeuker, J.H., Kouw, E., Hofker, H.S., Ploeg, R., Beese, U., Siersema, P.D., Vleggaar, F.P., Molenaar, I.Q., Aktas, H., Guchelaar, I., Dutch Pancreatitis Study Grp, Gastroenterology & Hepatology, Surgery, RS: NUTRIM - R2 - Liver and digestive health, and MUMC+: MA Heelkunde (9)

Subjects
medicine.medical_specialty, Randomization, diagnosis, SURGICAL DRAINAGE, duodenum-preserving resection, Other Research Radboud Institute for Molecular Life Sciences [Radboudumc 0], duct, GUIDELINES, 01 natural sciences, law.invention, Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18], 03 medical and health sciences, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], 0302 clinical medicine, Superiority Trial, All institutes and research themes of the Radboud University Medical Center, Quality of life, Randomized controlled trial, law, Internal medicine, medicine, MANAGEMENT, 030212 general & internal medicine, 0101 mathematics, Pancreatitis, chronic, therapy, medicine.diagnostic_test, business.industry, 010102 general mathematics, General Medicine, head, medicine.disease, Endoscopy, Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10], Pancreatitis, Observational study, business
Abstract

Importance: For patients with painful chronic pancreatitis, surgical treatment is postponed until medical and endoscopic treatment have failed. Observational studies have suggested that earlier surgery could mitigate disease progression, providing better pain control and preserving pancreatic function. Objective: To determine whether early surgery is more effective than the endoscopy-first approach in terms of clinical outcomes. Design, Setting, and Participants: The ESCAPE trial was an unblinded, multicenter, randomized clinical superiority trial involving 30 Dutch hospitals participating in the Dutch Pancreatitis Study Group. From April 2011 until September 2016, a total of 88 patients with chronic pancreatitis, a dilated main pancreatic duct, and who only recently started using prescribed opioids for severe pain (strong opioids for ≤2 months or weak opioids for ≤6 months) were included. The 18-month follow-up period ended in March 2018. Interventions: There were 44 patients randomized to the early surgery group who underwent pancreatic drainage surgery within 6 weeks after randomization and 44 patients randomized to the endoscopy-first approach group who underwent medical treatment, endoscopy including lithotripsy if needed, and surgery if needed. Main Outcomes and Measures: The primary outcome was pain, measured on the Izbicki pain score and integrated over 18 months (range, 0-100 [increasing score indicates more pain severity]). Secondary outcomes were pain relief at the end of follow-up; number of interventions, complications, hospital admissions; pancreatic function; quality of life (measured on the 36-Item Short Form Health Survey [SF-36]); and mortality. Results: Among 88 patients who were randomized (mean age, 52 years; 21 (24%) women), 85 (97%) completed the trial. During 18 months of follow-up, patients in the early surgery group had a lower Izbicki pain score than patients in the group randomized to receive the endoscopy-first approach group (37 vs 49; between-group difference, -12 points [95% CI, -22 to -2]; P =.02). Complete or partial pain relief at end of follow-up was achieved in 23 of 40 patients (58%) in the early surgery vs 16 of 41 (39%)in the endoscopy-first approach group (P =.10). The total number of interventions was lower in the early surgery group (median, 1 vs 3; P

Published
2020

24. Differential association of two PTPN22 coding variants with Crohn’s disease and ulcerative colitis

Author

Weersma R K, Roberts R L, Gearry R B, Ponsioen C Y, Wijmenga C, van Bodegraven A A, Crusius J B, Barclay M L, Bottini N, López-Nevot M A, Cueto I, Nieto A, Alcain G, Taxonera C, Mendoza J L, Rodrigo L, Cardeña C, van Sommeren S, Gómez-García M, Fransen K, Espino-Paisán L, Diaz-Gallo L M, Urcelay E, Merriman T R, Alizadeh B Z, and Martin J

Subjects
Medicine
Published
2010
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26. Prospects for fundamental physics with LISA

Author

Barausse, Enrico, primary, Berti, Emanuele, additional, Hertog, Thomas, additional, Hughes, Scott A., additional, Jetzer, Philippe, additional, Pani, Paolo, additional, Sotiriou, Thomas P., additional, Tamanini, Nicola, additional, Witek, Helvi, additional, Yagi, Kent, additional, Yunes, Nicolás, additional, Abdelsalhin, T., additional, Achucarro, A., additional, van Aelst, K., additional, Afshordi, N., additional, Akcay, S., additional, Annulli, L., additional, Arun, K. G., additional, Ayuso, I., additional, Baibhav, V., additional, Baker, T., additional, Bantilan, H., additional, Barreiro, T., additional, Barrera-Hinojosa, C., additional, Bartolo, N., additional, Baumann, D., additional, Belgacem, E., additional, Bellini, E., additional, Bellomo, N., additional, Ben-Dayan, I., additional, Bena, I., additional, Benkel, R., additional, Bergshoefs, E., additional, Bernard, L., additional, Bernuzzi, S., additional, Bertacca, D., additional, Besancon, M., additional, Beutler, F., additional, Beyer, F., additional, Bhagwat, S., additional, Bicak, J., additional, Biondini, S., additional, Bize, S., additional, Blas, D., additional, Boehmer, C., additional, Boller, K., additional, Bonga, B., additional, Bonvin, C., additional, Bosso, P., additional, Bozzola, G., additional, Brax, P., additional, Breitbach, M., additional, Brito, R., additional, Bruni, M., additional, Brügmann, B., additional, Bulten, H., additional, Buonanno, A., additional, Burko, L. M., additional, Burrage, C., additional, Cabral, F., additional, Calcagni, G., additional, Caprini, C., additional, Cárdenas-Avendaño, A., additional, Celoria, M., additional, Chatziioannou, K., additional, Chernoff, D., additional, Clough, K., additional, Coates, A., additional, Comelli, D., additional, Compère, G., additional, Croon, D., additional, Cruces, D., additional, Cusin, G., additional, Dalang, C., additional, Danielsson, U., additional, Das, S., additional, Datta, S., additional, de Boer, J., additional, De Luca, V., additional, De Rham, C., additional, Desjacques, V., additional, Destounis, K., additional, Filippo, F. Di, additional, Dima, A., additional, Dimastrogiovanni, E., additional, Dolan, S., additional, Doneva, D., additional, Duque, F., additional, Durrer, R., additional, East, W., additional, Easther, R., additional, Elley, M., additional, Ellis, J. R., additional, Emparan, R., additional, Ezquiaga, J. M., additional, Fairbairn, M., additional, Fairhurst, S., additional, Farmer, H. F., additional, Fasiello, M. R., additional, Ferrari, V., additional, Ferreira, P. G., additional, Ficarra, G., additional, Figueras, P., additional, Fisenko, S., additional, Foffa, S., additional, Franchini, N., additional, Franciolini, G., additional, Fransen, K., additional, Frauendiener, J., additional, Frusciante, N., additional, Fujita, R., additional, Gair, J., additional, Ganz, A., additional, Garcia, P., additional, Garcia-Bellido, J., additional, Garriga, J., additional, Geiger, R., additional, Geng, C., additional, Gergely, L. Á., additional, Germani, C., additional, Gerosa, D., additional, Giddings, S. B., additional, Gourgoulhon, E., additional, Grandclement, P., additional, Graziani, L., additional, Gualtieri, L., additional, Haggard, D., additional, Haino, S., additional, Halburd, R., additional, Han, W.-B., additional, Hawken, A. J., additional, Hees, A., additional, Heng, I. S., additional, Hennig, J., additional, Herdeiro, C., additional, Hervik, S., additional, Holten, J. v., additional, Hoyle, C. J. D., additional, Hu, Y., additional, Hull, M., additional, Ikeda, T., additional, Isi, M., additional, Jenkins, A., additional, Julié, F., additional, Kajfasz, E., additional, Kalaghatgi, C., additional, Kaloper, N., additional, Kamionkowski, M., additional, Karas, V., additional, Kastha, S., additional, Keresztes, Z., additional, Kidder, L., additional, Kimpson, T., additional, Klein, A., additional, Klioner, S., additional, Kokkotas, K., additional, Kolesova, H., additional, Kolkowitz, S., additional, Kopp, J., additional, Koyama, K., additional, Krishnendu, N. V., additional, Kroon, J. A. V., additional, Kunz, M., additional, Lahav, O., additional, Landragin, A., additional, Lang, R. N., additional, Poncin-Lafitte, C. Le, additional, Lemos, J., additional, Li, B., additional, Liberati, S., additional, Liguori, M., additional, Lin, F., additional, Liu, G., additional, Lobo, F. S. N., additional, Loll, R., additional, Lombriser, L., additional, Lovelace, G., additional, Macedo, R. P., additional, Madge, E., additional, Maggio, E., additional, Maggiore, M., additional, Marassi, S., additional, Marcoccia, P., additional, Markakis, C., additional, Martens, W., additional, Martinovic, K., additional, Martins, C. J. A. P., additional, Maselli, A., additional, Mastrogiovanni, S., additional, Matarrese, S., additional, Matas, A., additional, Mavromatos, N. E., additional, Mazumdar, A., additional, Meerburg, P. D., additional, Megias, E., additional, Miller, J., additional, Mimoso, J. P., additional, Mittnacht, L., additional, Montero, M. M., additional, Moore, B., additional, Martin-Moruno, P., additional, Musco, I., additional, Nakano, H., additional, Nampalliwar, S., additional, Nardini, G., additional, Nielsen, A., additional, Novák, J., additional, Nunes, N. J., additional, Okounkova, M., additional, Oliveri, R., additional, Oppizzi, F., additional, Orlando, G., additional, Oshita, N., additional, Pappas, G., additional, Paschalidis, V., additional, Peiris, H., additional, Peloso, M., additional, Perkins, S., additional, Pettorino, V., additional, Pikovski, I., additional, Pilo, L., additional, Podolsky, J., additional, Pontzen, A., additional, Prabhat, S., additional, Pratten, G., additional, Prokopec, T., additional, Prouza, M., additional, Qi, H., additional, Raccanelli, A., additional, Rajantie, A., additional, Randall, L., additional, Raposo, G., additional, Raymond, V., additional, Renaux-Petel, S., additional, Ricciardone, A., additional, Riotto, A., additional, Robson, T., additional, Roest, D., additional, Rollo, R., additional, Rosofsky, S., additional, Ruan, J. J., additional, Rubiera-García, D., additional, Ruiz, M., additional, Rusu, M., additional, Sabatie, F., additional, Sago, N., additional, Sakellariadou, M., additional, Saltas, I. D., additional, Sberna, L., additional, Sathyaprakash, B., additional, Scheel, M., additional, Schmidt, P., additional, Schutz, B., additional, Schwaller, P., additional, Shao, L., additional, Shapiro, S. L., additional, Shoemaker, D., additional, Silva, A. d., additional, Simpson, C., additional, Sopuerta, C. F., additional, Spallicci, A., additional, Stefanek, B. A., additional, Stein, L., additional, Stergioulas, N., additional, Stott, M., additional, Sutton, P., additional, Svarc, R., additional, Tagoshi, H., additional, Tahamtan, T., additional, Takeda, H., additional, Tanaka, T., additional, Tantilian, G., additional, Tasinato, G., additional, Tattersall, O., additional, Teukolsky, S., additional, Tiec, A. L., additional, Theureau, G., additional, Trodden, M., additional, Tolley, A., additional, Toubiana, A., additional, Traykova, D., additional, Tsokaros, A., additional, Unal, C., additional, Unnikrishnan, C. S., additional, Vagenas, E. C., additional, Valageas, P., additional, Vallisneri, M., additional, Brand, J. Van den, additional, Broeck, C. Van den, additional, de Meent, M. van, additional, Vanhove, P., additional, Varma, V., additional, Veitch, J., additional, Vercnocke, B., additional, Verde, L., additional, Vernieri, D., additional, Vernizzi, F., additional, Vicente, R., additional, Vidotto, F., additional, Visser, M., additional, Vlah, Z., additional, Vretinaris, S., additional, Völkel, S., additional, Wang, Q., additional, Wang, Yu-Tong, additional, Werner, M. C., additional, Westernacher, J., additional, Weygaert, R. v. d., additional, Wiltshire, D., additional, Wiseman, T., additional, Wolf, P., additional, Wu, K., additional, Yamada, K., additional, Yang, H., additional, Yi, L., additional, Yue, X., additional, Yvon, D., additional, Zilhão, M., additional, Zimmerman, A., additional, and Zumalacarregui, M., additional

Published
2020
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27. IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes

Author

Momozawa, Y, Dmitrieva, J, Theatre, E, Deffontaine, V, Rahmouni, S, Charloteaux, B, Crins, F, Docampo, E, Elansary, M, Gori, AS, Lecut, C, Mariman, R, Mni, M, Oury, C, Altukhov, I, Alexeev, D, Aulchenko, Y, Amininejad, L, Bouma, G, Hoentjen, F, Lowenberg, M, Oldenburg, B, Pierik, MJ, de Jong, AE, van der Woude, C.J., Visschedijk, MC, Lathrop, M, Hugot, JP, Weersma, RK, Vos, M, Franchimont, D, Vermeire, S, Kubo, M, Louis, E, Georges, M, Abraham, C, Achkar, JP, Ahmad, T, Ananthakrishnan, AN, Andersen, V, Anderson, CA, Andrews, JM, Annese, V, Aumais, G, Baidoo, L, Baldassano, RN, Bampton, PA, Barclay, M, Barrett, JC, Bayless, TM, Bethge, J, Bitton, A, Boucher, G, Brand, S, Brandt, B, Brant, SR, Buning, C, Chew, A, Cho, JH, Cleynen, I, Cohain, A, Croft, A, Daly, MJ, D'Amato, M, Danese, S, Jong, D, Denapiene, G, Denson, LA, Devaney, KL, Dewit, O, D'Inca, R, Dubinsky, M, Duerr, RH, Edwards, C, Ellinghaus, D, Essers, J, Ferguson, LR, Festen, EA, Fleshner, P, Florin, T, Franke, A, Fransen, K, Gearry, R, Gieger, C, Glas, J, Goyette, P, Green, T, Griffiths, AM, Guthery, SL, Hakonarson, H, Halfvarson, J, Hanigan, K, Haritunians, T, de Hart, A, Hawkey, C, Hayward, NK, Hedl, M, Henderson, P, Hu, XH, Huang, HL, Hui, KY, Imielinski, M, Ippoliti, A, Jonaitis, L, Jostins, L, Karlsen, TH, Kennedy, NA, Khan, MA, Kiudelis, G, Krishnaprasad, K, Kugathasan, S, Kupcinskas, L, Latiano, A, Laukens, D, Lawrance, IC, Lee, JC, Lees, CW, Leja, M, van Limbergen, J, Lionetti, P, Liu, JZ, Mahy, G, Mansfield, J, Massey, D, Mathew, CG, McGovern, DPB, Milgrom, R, Mitrovic, M, Montgomery, GW, Mowat, C, Newman, W, Ng, A, Ng, SC, Ng, SME, Nikolaus, S, Ning, K, Nothen, M, Oikonomou, I, Palmieri, O, Parkes, M, Phillips, A, Ponsioen, CY, Potocnik, U, Prescott, NJ, Proctor, DD, Radford-Smith, G, Rahier, JF, Raychaudhuri, S, Regueiro, M, Rieder, F, Rioux, JD, Ripke, S, Roberts, R, Russell, RK, Sanderson, JD, Sans, M, Satsangi, J, Schadt, EE, Schreiber, S, Schulte, D, Schumm, LP, Scott, R, Seielstad, M, Sharma, Y, Silverberg, MS, Simms, LA, Skieceviciene, J, Spain, SL, Steinhart, AH, Stempak, JM, Stronati, L, Sventoraityte, J, Targan, SR, Taylor, KM, Velde, A, Torkvist, L, Tremelling, M, van Sommeren, S, Vasiliauskas, E, Verspaget, HW, Walters, T, Wang, K, Wang, MH, Wei, Z, Whiteman, D, Wijmenga, C, Wilson, DC, Winkelmann, J, Xavier, RJ, Zhang, B, Zhang, CK, Zhang, H, Zhang, W, Zhao, HY, Zhao, ZZ, Momozawa, Y, Dmitrieva, J, Theatre, E, Deffontaine, V, Rahmouni, S, Charloteaux, B, Crins, F, Docampo, E, Elansary, M, Gori, A, Lecut, C, Mariman, R, Mni, M, Oury, C, Altukhov, I, Alexeev, D, Aulchenko, Y, Amininejad, L, Bouma, G, Hoentjen, F, Lowenberg, M, Oldenburg, B, Pierik, Mj, vander Meulen-de Jong, Ae, van der Woude, Cj, Visschedijk, Mc, Lathrop, M, Hugot, Jp, Weersma, Rk, De Vos, M, Franchimont, D, Vermeire, S, Kubo, M, Louis, E, Georges, M, Abraham, C, Achkar, Jp, Ahmad, T, Ananthakrishnan, An, Andersen, V, Anderson, Ca, Andrews, Jm, Annese, V, Aumais, G, Baidoo, L, Baldassano, Rn, Bampton, Pa, Barclay, M, Barrett, Jc, Bayless, Tm, Bethge, J, Bitton, A, Boucher, G, Brand, S, Brandt, B, Brant, Sr, Buning, C, Chew, A, Cho, Jh, Cleynen, I, Cohain, A, Croft, A, Daly, Mj, D'Amato, M, Danese, S, De Jong, D, Denapiene, G, Denson, La, Devaney, Kl, Dewit, O, D'Inca, R, Dubinsky, M, Duerr, Rh, Edwards, C, Ellinghaus, D, Essers, J, Ferguson, Lr, Festen, Ea, Fleshner, P, Florin, T, Franke, A, Fransen, K, Gearry, R, Gieger, C, Glas, J, Goyette, P, Green, T, Griffiths, Am, Guthery, Sl, Hakonarson, H, Halfvarson, J, Hanigan, K, Haritunians, T, Hart, A, Hawkey, C, Hayward, Nk, Hedl, M, Henderson, P, Hu, Xh, Huang, Hl, Hui, Ky, Imielinski, M, Ippoliti, A, Jonaitis, L, Jostins, L, Karlsen, Th, Kennedy, Na, Khan, Ma, Kiudelis, G, Krishnaprasad, K, Kugathasan, S, Kupcinskas, L, Latiano, A, Laukens, D, Lawrance, Ic, Lee, Jc, Lees, Cw, Leja, M, Van Limbergen, J, Lionetti, P, Liu, Jz, Mahy, G, Mansfield, J, Massey, D, Mathew, Cg, Mcgovern, Dpb, Milgrom, R, Mitrovic, M, Montgomery, Gw, Mowat, C, Newman, W, Ng, A, Ng, Sc, Ng, Sme, Nikolaus, S, Ning, K, Nothen, M, Oikonomou, I, Palmieri, O, Parkes, M, Phillips, A, Ponsioen, Cy, Potocnik, U, Prescott, Nj, Proctor, Dd, Radford-Smith, G, Rahier, Jf, Raychaudhuri, S, Regueiro, M, Rieder, F, Rioux, Jd, Ripke, S, Roberts, R, Russell, Rk, Sanderson, Jd, Sans, M, Satsangi, J, Schadt, Ee, Schreiber, S, Schulte, D, Schumm, Lp, Scott, R, Seielstad, M, Sharma, Y, Silverberg, M, Simms, La, Skieceviciene, J, Spain, Sl, Steinhart, Ah, Stempak, Jm, Stronati, L, Sventoraityte, J, Targan, Sr, Taylor, Km, ter Velde, A, Torkvist, L, Tremelling, M, van Sommeren, S, Vasiliauskas, E, Verspaget, Hw, Walters, T, Wang, K, Wang, Mh, Wei, Z, Whiteman, D, Wijmenga, C, Wilson, Dc, Winkelmann, J, Xavier, Rj, Zhang, B, Zhang, Ck, Zhang, H, Zhang, W, Zhao, Hy, Zhao, Zz, Gastroenterology & Hepatology, UCL - SSS/IREC/GAEN - Pôle d'Hépato-gastro-entérologie, and UCL - (MGD) Service de gastro-entérologie

Subjects
Adult, Male, Multifactorial Inheritance, QUANTITATIVE TRAIT LOCUS, Genotype, SEQUENCING DATA, Quantitative Trait Loci, SUSCEPTIBILITY, Polymorphism, Single Nucleotide, Article, Cohort Studies, CODING VARIANTS, Crohn Disease, 80 and over, Journal Article, Medicine and Health Sciences, LOCUS, Humans, Genetic Predisposition to Disease, Polymorphism, GENOME-WIDE ASSOCIATION, Genetic Association Studies, Aged, Aged, 80 and over, Science & Technology, Female, Gene Expression Profiling, Inflammatory Bowel Diseases, Middle Aged, Sequence Analysis, DNA, COMPLEX TRAITS, Biology and Life Sciences, Single Nucleotide, DNA, CROHNS-DISEASE, Multidisciplinary Sciences, QUANTITATIVE TRAIT, RARE VARIANTS, Science & Technology - Other Topics, LOW-FREQUENCY, Sequence Analysis, INFLAMMATORY-BOWEL-DISEASE
Abstract

GWAS have identified >200 risk loci for Inflammatory Bowel Disease (IBD). The majority of disease associations are known to be driven by regulatory variants. To identify the putative causative genes that are perturbed by these variants, we generate a large transcriptome data set (nine disease-relevant cell types) and identify 23,650 cis-eQTL. We show that these are determined by ∼9720 regulatory modules, of which ∼3000 operate in multiple tissues and ∼970 on multiple genes. We identify regulatory modules that drive the disease association for 63 of the 200 risk loci, and show that these are enriched in multigenic modules. Based on these analyses, we resequence 45 of the corresponding 100 candidate genes in 6600 Crohn disease (CD) cases and 5500 controls, and show with burden tests that they include likely causative genes. Our analyses indicate that ≥10-fold larger sample sizes will be required to demonstrate the causality of individual genes using this approach., Most of the more than 200 known genetic risk loci for inflammatory bowel disease (IBD) reside in regulatory regions. Here, the authors provide eQTL datasets for six circulating immune cell types and ileal, colonic and rectal biopsies to map regulatory modules and identify potential causative genes for IBD.

Published
2018

28. Black holes, gravitational waves and fundamental physics: A roadmap

Author

Barack, L. Cardoso, V. Nissanke, S. Sotiriou, T.P. Askar, A. Belczynski, C. Bertone, G. Bon, E. Blas, D. Brito, R. Bulik, T. Burrage, C. Byrnes, C.T. Caprini, C. Chernyakova, M. Chruściel, P. Colpi, M. Ferrari, V. Gaggero, D. Gair, J. García-Bellido, J. Hassan, S.F. Heisenberg, L. Hendry, M. Heng, I.S. Herdeiro, C. Hinderer, T. Horesh, A. Kavanagh, B.J. Kocsis, B. Kramer, M. Le Tiec, A. Mingarelli, C. Nardini, G. Nelemans, G. Palenzuela, C. Pani, P. Perego, A. Porter, E.K. Rossi, E.M. Schmidt, P. Sesana, A. Sperhake, U. Stamerra, A. Stein, L.C. Tamanini, N. Tauris, T.M. Urena-López, L.A. Vincent, F. Volonteri, M. Wardell, B. Wex, N. Yagi, K. Abdelsalhin, T. Aloy, M.Á. Amaro-Seoane, P. Annulli, L. Arca-Sedda, M. Bah, I. Barausse, E. Barakovic, E. Benkel, R. Bennett, C.L. Bernard, L. Bernuzzi, S. Berry, C.P.L. Berti, E. Bezares, M. Blanco-Pillado, J.J. Blázquez-Salcedo, J.L. Bonetti, M. Bošković, M. Bosnjak, Z. Bricman, K. Brügmann, B. Capelo, P.R. Carloni, S. Cerdá-Durán, P. Charmousis, C. Chaty, S. Clerici, A. Coates, A. Colleoni, M. Collodel, L.G. Compère, G. Cook, W. Cordero-Carrión, I. Correia, M. De La Cruz-Dombriz, Á. Czinner, V.G. Destounis, K. Dialektopoulos, K. Doneva, D. Dotti, M. Drew, A. Eckner, C. Edholm, J. Emparan, R. Erdem, R. Ferreira, M. Ferreira, P.G. Finch, A. Font, J.A. Franchini, N. Fransen, K. Gal'tsov, D. Ganguly, A. Gerosa, D. Glampedakis, K. Gomboc, A. Goobar, A. Gualtieri, L. Guendelman, E. Haardt, F. Harmark, T. Hejda, F. Hertog, T. Hopper, S. Husa, S. Ihanec, N. Ikeda, T. Jaodand, A. Jetzer, P. Jimenez-Forteza, X. Kamionkowski, M. Kaplan, D.E. Kazantzidis, S. Kimura, M. Kobayashi, S. Kokkotas, K. Krolik, J. Kunz, J. Lämmerzahl, C. Lasky, P. Lemos, J.P.S. Levi Said, J. Liberati, S. Lopes, J. Luna, R. Ma, Y.-Z. Maggio, E. Mangiagli, A. Montero, M.M. Maselli, A. Mayer, L. Mazumdar, A. Messenger, C. Ménard, B. Minamitsuji, M. Moore, C.J. Mota, D. Nampalliwar, S. Nerozzi, A. Nichols, D. Nissimov, E. Obergaulinger, M. Obers, N.A. Oliveri, R. Pappas, G. Pasic, V. Peiris, H. Petrushevska, T. Pollney, D. Pratten, G. Rakic, N. Racz, I. Radia, M. Ramazanoǧlu, F.M. Ramos-Buades, A. Raposo, G. Rogatko, M. Rosca-Mead, R. Rosinska, D. Rosswog, S. Ruiz-Morales, E. Sakellariadou, M. Sanchis-Gual, N. Sharan Salafia, O. Samajdar, A. Sintes, A. Smole, M. Sopuerta, C. Souza-Lima, R. Stalevski, M. Stergioulas, N. Stevens, C. Tamfal, T. Torres-Forné, A. Tsygankov, S. İ Ünlütürk, Ki. Valiante, R. Van De Meent, M. Velhinho, J. Verbin, Y. Vercnocke, B. Vernieri, D. Vicente, R. Vitagliano, V. Weltman, A. Whiting, B. Williamson, A. Witek, H. Wojnar, A. Yakut, K. Yan, H. Yazadjiev, S. Zaharijas, G. Zilhão, M.

Subjects
General Relativity and Quantum Cosmology
Abstract

The grand challenges of contemporary fundamental physics-dark matter, dark energy, vacuum energy, inflation and early universe cosmology, singularities and the hierarchy problem-all involve gravity as a key component. And of all gravitational phenomena, black holes stand out in their elegant simplicity, while harbouring some of the most remarkable predictions of General Relativity: event horizons, singularities and ergoregions. The hitherto invisible landscape of the gravitational Universe is being unveiled before our eyes: the historical direct detection of gravitational waves by the LIGO-Virgo collaboration marks the dawn of a new era of scientific exploration. Gravitational-wave astronomy will allow us to test models of black hole formation, growth and evolution, as well as models of gravitational-wave generation and propagation. It will provide evidence for event horizons and ergoregions, test the theory of General Relativity itself, and may reveal the existence of new fundamental fields. The synthesis of these results has the potential to radically reshape our understanding of the cosmos and of the laws of Nature. The purpose of this work is to present a concise, yet comprehensive overview of the state of the art in the relevant fields of research, summarize important open problems, and lay out a roadmap for future progress. This write-up is an initiative taken within the framework of the European Action on 'Black holes, Gravitational waves and Fundamental Physics'. © 2019 IOP Publishing Ltd.

Published
2019

32. Evolution of primary resistance in Belgium (1995–2000)

Author

Derdelinckx, I, Van Vaerenbergh, K, De Wit, S, Zissis, G, Van Wanzeele, F, Verhofstede, C, Florence, E, Fransen, K, Lacor, P, Muyldermans, G, Moutschen, M, Vaira, D, Debaisieux, L, Van Dooren, J-P, De Boeck, K, Louwagie, J, Van Wijngaerden, E, Van Ranst, M, and Vandamme, A-M

Published
2003

35. IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes

Author

Momozawa, Y., Dmitrieva, J., Theatre, E., Deffontaine, V., Rahmouni, S., Charloteaux, B., Crins, F., Docampo, E., Elansary, M., Gori, A.S., Lecut, C., Mariman, R., Mni, M., Oury, C., Altukhov, I., Alexeev, D., Aulchenko, Y., Amininejad, L., Bouma, G., Hoentjen, F., Lowenberg, M., Oldenburg, B., Pierik, M.J., vander Meulen-de Jong, A.E., Woude, C.J. van der, Visschedijk, M.C., Lathrop, M., Hugot, J.P., Weersma, R.K., Vos, M. de, Franchimont, D., Vermeire, S., Kubo, M., Louis, E., Georges, M., Abraham, C., Achkar, J.P., Ahmad, T., Ananthakrishnan, A.N., Andersen, V., Anderson, C.A., Andrews, J.M., Annese, V., Aumais, G., Baidoo, L., Baldassano, R.N., Bampton, P.A., Barclay, M., Barrett, J.C., Bayless, T.M., Bethge, J., Bitton, A., Boucher, G., Brand, S., Brandt, B., Brant, S.R., Buning, C., Chew, A., Cho, J.H., Cleynen, I., Cohain, A., Croft, A., Daly, M.J., D'Amato, M., Danese, S., Jong, D. de, Denapiene, G., Denson, L.A., Devaney, K.L., Dewit, O., D'Inca, R., Dubinsky, M., Duerr, R.H., Edwards, C., Ellinghaus, D., Essers, J., Ferguson, L.R., Festen, E.A., Fleshner, P., Florin, T., Franke, A., Fransen, K., Gearry, R., Gieger, C., Glas, J., Goyette, P., Green, T., Griffiths, A.M., Guthery, S.L., Hakonarson, H., Halfvarson, J., Hanigan, K., Haritunians, T., Hart, A., Hawkey, C., Hayward, N.K., Hedl, M., Henderson, P., Hu, X.H., Huang, H.L., Hui, K.Y., Imielinski, M., Ippoliti, A., Jonaitis, L., Jostins, L., Karlsen, T.H., Kennedy, N.A., Khan, M.A., Kiudelis, G., Krishnaprasad, K., Kugathasan, S., Kupcinskas, L., Latiano, A., Laukens, D., Lawrance, I.C., Lee, J.C., Lees, C.W., Leja, M., Limbergen, J. van, Lionetti, P., Liu, J.Z., Mahy, G., Mansfield, J., Massey, D., Mathew, C.G., McGovern, D.P.B., Milgrom, R., Mitrovic, M., Montgomery, G.W., Mowat, C., Newman, W., Ng, A., Ng, S.C., Ng, S.M.E., Nikolaus, S., Ning, K., Nothen, M., Oikonomou, I., Palmieri, O., Parkes, M., Phillips, A., Ponsioen, C.Y., Potocnik, U., Prescott, N.J., Proctor, D.D., Radford-Smith, G., Rahier, J.F., Raychaudhuri, S., Regueiro, M., Rieder, F., Rioux, J.D., Ripke, S., Roberts, R., Russell, R.K., Sanderson, J.D., Sans, M., Satsangi, J., Schadt, E.E., Schreiber, S., Schulte, D., Schumm, L.P., Scott, R., Seielstad, M., Sharma, Y., Silverberg, M.S., Simms, L.A., Skieceviciene, J., Spain, S.L., Steinhart, A.H., Stempak, J.M., Stronati, L., Sventoraityte, J., Targan, S.R., Taylor, K.M., Velde, A. ter, Torkvist, L., Tremelling, M., Sommeren, S. van, Vasiliauskas, E., Verspaget, H.W., Walters, T., Wang, K., Wang, M.H., Wei, Z., Whiteman, D., Wijmenga, C., Wilson, D.C., Winkelmann, J., Xavier, R.J., Zhang, B., Zhang, C.K., Zhang, H., Zhang, W., Zhao, H.Y., Zhao, Z.Z., and Int IBD Genetics Consortium

Published
2018

36. Identity leadership going global: Validation of the Identity Leadership Inventory across 20 countries

Author

Dick, R., Lemoine, J. E., Steffens, N. K., Kerschreiter, R., Akfirat, S. A., Avanzi, L., Dumont, K., Epitropaki, O., Fransen, K., Giessner, S., González, R., Kark, R., Lipponen, J., Markovits, Y., Monzani, L., Orosz, G., Pandey, D., Roland‐Lévy, C., Schuh, S., Sekiguchi, T., Song, L. J., Stouten, J., Tatachari, S., Valdenegro, D., Bunderen, L., Vörös, V., Wong, S. I., Zhang, X., and Haslam, S. A.

Subjects
leadership, social identity, cross‐cultural validation, Identity Leadership Inventory
Abstract

Recent theorizing applying the social identity approach to leadership proposes a four‐dimensional model of identity leadership that centres on leaders’ management of a shared sense of ‘we’ and ‘us’. This research validates a scale assessing this model – the Identity Leadership Inventory (ILI). We present results from an international project with data from all six continents and from more than 20 countries/regions with 5,290 participants. The ILI was translated (using back‐translation methods) into 13 different languages (available in the Appendix S1) and used along with measures of other leadership constructs (i.e., leader–member exchange [LMX], transformational leadership, and authentic leadership) as well as employee attitudes and (self‐reported) behaviours – namely identification, trust in the leader, job satisfaction, innovative work behaviour, organizational citizenship behaviour, and burnout. Results provide consistent support for the construct, discriminant, and criterion validity of the ILI across countries. We show that the four dimensions of identity leadership are distinguishable and that they relate to important work‐related attitudes and behaviours above and beyond other leadership constructs. Finally, we also validate a short form of the ILI, noting that is likely to have particular utility in applied contexts.

Published
2018

42. HIV-1 sub-subtype F1 outbreak among MSM in Belgium

Author

Vinken, L, Fransen, K, Pineda-Peña, A C, Alexiev, I, Balotta, C, Debaisieux, L, Devaux, C, García Ribas, S, Gomes, P, Incardona, F, Kaiser, R, Ruelle, J, Sayan, M, Paraschiv, S, Paredes, R, Peeters, M, Sonnerborg, A, Vancutsem, E, Van den Wijngaert, S, Van Ranst, M, Verhofstede, C, Vandamme, A-M, Lemey, P, Van Laethem, K, Faculty of Sciences and Bioengineering Sciences, UGENT VUB Alliance Research Group in Information Systems, Faculty of Medicine and Pharmacy, Supporting clinical sciences, Microbiology and Infection Control, Clinical Biology, Department of Bio-engineering Sciences, Faculty of Law and Criminology, and Fundamental rights centre

Abstract

HIV-1 non-B subtype infections have been observed in Belgium since the 1980s. However, subtype B predominates amongst men having sex with men (MSM), whereas other subtypes are mainly associated with sub-Saharan African migrants and heterosexual risk behavior. In the last decade, subtype F1 diagnoses have increased substantially in Belgium, representing 9% of newly diagnosed and therapy-naïve HIV-1 patients linked to care in 2014. In the present study, the Belgian subtype F1 epidemic has been characterized within a global context, where F1 is responsible for

Published
2017

43. A21 HIV-1 sub-subtype F1 outbreak among MSM in Belgium

Author

Vinken, L., Fransen, K., Pineda-Peña, A.C., Alexiev, I., Balotta, C., Debaisieux, L., Devaux, C., García Ribas, S., Gomes, P., Incardona, F., Kaiser, R, Ruelle, J., Sayan, M., Paraschiv, S., Paredes, Roger, Peeters, M., Sonnerborg, A., Vancutsem, E., Van den Wijngaert, S., Van Ranst, M., Verhofstede, C., Vandamme, A.-M., Lemey, P., Van Laethem, K., and Universitat Autònoma de Barcelona

Published
2017

44. Easy and accurate reconstruction of whole HIV genomes from short-read sequence data

Author

Wymant, C, Blanquart, F, Gall, A, Bakker, M, Bezemer, D, Croucher, N, Golubchik, T, Hall, M, Hillebregt, M, Ong, SH, Albert, J, Bannert, N, Fellay, J, Fransen, K, Gourlay, A, Grabowski, K, Gunsenheimer-Bartmeyer, B, Günthard, H, Kivelä, P, Kouyos, R, Laeyendecker, O, Liitsola, K, Meyer, L, Porter, K, Ristola, M, Van Sighem, A, Vanham, G, Berkhout, B, Cornelissen, M, Kellam, P, Reiss, P, Fraser, C, and The BEEHIVE Collaboration

Subjects
The BEEHIVE Collaboration
Abstract

Next-generation sequencing has yet to be widely adopted for HIV. The difficulty of accurately reconstructing the consensus sequence of a quasispecies from reads (short fragments of DNA) in the presence of rapid between- and within-host evolution may have presented a barrier. In particular, mapping (aligning) reads to a reference sequence leads to biased loss of information; this bias can distort epidemiological and evolutionary conclusions. De novo assembly avoids this bias by effectively aligning the reads to themselves, producing a set of sequences called contigs. However contigs provide only a partial summary of the reads, misassembly may result in their having an incorrect structure, and no information is available at parts of the genome where contigs could not be assembled. To address these problems we developed the tool shiver to preprocess reads for quality and contamination, then map them to a reference tailored to the sample using corrected contigs supplemented with existing reference sequences. Run with two commands per sample, it can easily be used for large heterogeneous data sets. We use shiver to reconstruct the consensus sequence and minority variant information from paired-end short-read data produced with the Illumina platform, for 65 existing publicly available samples and 50 new samples. We show the systematic superiority of mapping to shiver ’s constructed reference over mapping the same reads to the standard reference HXB2: an average of 29 bases per sample are called differently, of which 98.5% are supported by higher coverage. We also provide a practical guide to working with imperfect contigs.

Published
2016

45. Does Social Capital Benefit Older Adults' Health and Well-Being? The Mediating Role of Physical Activity.

Author

Boen, F., Pelssers, J., Scheerder, J., Vanbeselaere, N., Vos, S., Hurkmans, E., Smits, T., and Fransen, K.

Subjects
AGING, HEALTH status indicators, SURVEYS, SOCIAL capital, SOCIAL support, WELL-being, CROSS-sectional method, PHYSICAL activity, DATA analysis software, DESCRIPTIVE statistics
Abstract

Objectives: To assess whether social capital benefits older adults' self-rated health and well-being and whether physical activity mediates this relation. Methods: A survey study was conducted among members of a sociocultural organization (age ≥55 years), both cross-sectionally (baseline Time 1; N = 959) and longitudinally (3-year follow-up Time 2; N = 409). Results: Specific indicators of social capital were positively, though modestly, related to health and well-being at Time 1 and Time 2. Experienced connectedness with age peers emerged as the strongest predictor. Physical activity only mediated the relation with experienced safety in society. Discussion: The relative importance of older adults' experienced connectedness with their age peers underlines the importance of internalized group membership as a determinant of their health and well-being. Physical activity seems to play only a minor mediating role. [ABSTRACT FROM AUTHOR]

Published
2020
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46. Inherited determinants of Crohn's disease and ulcerative colitis phenotypes:a genetic association study

Author

Cleynen, Isabelle, Boucher, Gabrielle, Jostins, Luke, Schumm, L. Philip, Zeissig, Sebastian, Ahmad, Tariq, Andersen, Vibeke, Andrews, Jane M., Annese, Vito, Brand, Stephan, Brant, Steven R., Cho, Judy H., Daly, Mark J., Dubinsky, Marla, Duerr, Richard H., Ferguson, Lynnette R., Franke, Andre, Gearry, Richard B., Goyette, Philippe, Hakonarson, Hakon, Halfvarson, Jonas, Hov, Johannes R., Huang, Hailang, Kennedy, Nicholas A., Kupcinskas, Limas, Lawrance, Ian C., Lee, James C., Satsangi, Jack, Schreiber, Stephan, Théâtre, Emilie, Van Der Meulen De Jong, Andrea E, Weersma, Rinse K., Wilson, David C., Parkes, Miles, Vermeire, Severine, Rioux, John D., Mansfield, John, Silverberg, Mark S., Radford Smith, Graham, Mcgovern, Dermot P. B., Barrett, Jeffrey C., Lees, Charlie W, Abraham, C, Achkar, Jp, Ahmad, T, Amininejad, L, Ananthakrishnan, An, Andersen, V, Anderson, Ca, Andrews, Jm, Annese, V, Aumais, G, Baidoo, L, Baldassano, Rn, Bampton, Pa, Barclay, M, Barrett, Jc, Bayless, Tm, Bethge, J, Bis, Jc, Bitton, A, Boucher, G, Brand, S, Brandt, B, Brant, Sr, Büning, C, Chew, A, Cho, Jh, Cleynen, I, Cohain, A, Croft, A, Daly, Mj, D'Amato, M, Danese, S, De Jong, D, De Vos, M, Denapiene, G, Denson, La, Devaney, K, Dewit, O, D'Inca, R, Dubinsky, M, Duerr, Rh, Edwards, C, Ellinghaus, D, Essers, J, Ferguson, Lr, Festen, Ea, Fleshner, P, Florin, T, Franchimont, D, Franke, A, Fransen, K, Gearry, R, Georges, M, Gieger, C, Glas, J, Goyette, P, Green, T, Griffiths, Am, Guthery, Sl, Hakonarson, H, Halfvarson, J, Hanigan, K, Haritunians, T, Hart, A, Hawkey, C, Hayward, Nk, Hedl, M, Henderson, P, Hu, X, Huang, H, Hui, Ky, Imielinski, M, Ippoliti, A, Jonaitis, L, Jostins, L, Karlsen, Th, Kennedy, Na, Khan, Ma, Kiudelis, G, Krishnaprasad, K, Kugathasan, S, Kupcinskas, L, Latiano, A, Laukens, D, Lawrance, Ic, Lee, Jc, Lees, Cw, Leja, M, Van Limbergen, J, Lionetti, P, Liu, Jz, Louis, E, Mahy, G, Mansfield, J, Massey, D, Mathew, Cg, Mcgovern, Dp, Milgrom, R, Mitrovic, M, Montgomery, Gw, Mowat, C, Newman, W, Ng, A, Ng, Sc, Ng, Sm, Nikolaus, S, Ning, K, Nöthen, M, Oikonomou, I, Palmieri, O, Parkes, M, Phillips, A, Ponsioen, Cy, Potocnik, U, Prescott, Nj, Proctor, Dd, Radford Smith, G, Rahier, Jf, Raychaudhuri, S, Regueiro, M, Rieder, F, Rioux, Jd, Ripke, S, Roberts, R, Russell, Rk, Sanderson, Jd, Sans, M, Satsangi, J, Schadt, Ee, Schreiber, S, Schumm, Lp, Scott, R, Seielstad, M, Sharma, Y, Silverberg, Ms, Simms, La, Skieceviciene, J, Spain, Sl, Steinhart, A, Stempak, Jm, Stronati, Laura, Sventoraityte, J, Targan, Sr, Taylor, Km, ter Velde, A, Theatre, E, Torkvist, L, Tremelling, M, van der Meulen, A, van Sommeren, S, Vasiliauskas, E, Vermeire, S, Verspaget, Hw, Walters, T, Wang, K, Wang, Mh, Weersma, Rk, Wei, Z, Whiteman, D, Wijmenga, C, Wilson, Dc, Winkelmann, J, Xavier, Rj, Zeissig, S, Zhang, B, Zhang, Ck, Zhang, H, Zhang, W, Zhao, H, Zhao, Zz, UCL - SSS/IREC/GAEN - Pôle d'Hépato-gastro-entérologie, UCL - (MGD) Service de gastro-entérologie, and Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI)

Subjects
Male, 0301 basic medicine, CLINICAL-COURSE, Nod2 Signaling Adaptor Protein, Disease, SUSCEPTIBILITY, Inflammatory bowel disease, Major Histocompatibility Complex, 0302 clinical medicine, Crohn Disease, Maintenance therapy, NOD2, Medicine and Health Sciences, POPULATION, Immunoassay, RISK, Medicine(all), education.field_of_study, Crohn's disease, Hepatocyte Growth Factor, Medicine (all), INDUCTION, Articles, General Medicine, PRIMARY SCLEROSING CHOLANGITIS, Ulcerative colitis, 3. Good health, Phenotype, Female, 030211 gastroenterology & hepatology, Adult, medicine.medical_specialty, MAINTENANCE THERAPY, Genotype, Population, Polymorphism, Single Nucleotide, Risk Assessment, CLASSIFICATION, Primary sclerosing cholangitis, Young Adult, 03 medical and health sciences, inflammatory bowel disease, Proto-Oncogene Proteins, Internal medicine, medicine, Humans, Genetic Predisposition to Disease, education, Alleles, Genetic Association Studies, business.industry, medicine.disease, digestive system diseases, 030104 developmental biology, Immunology, Colitis, Ulcerative, business, FOLLOW-UP, HLA-DRB1 Chains, INFLAMMATORY-BOWEL-DISEASE
Abstract

Background: Crohn's disease and ulcerative colitis are the two major forms of inflammatory bowel disease; treatment strategies have historically been determined by this binary categorisation. Genetic studies have identified 163 susceptibility loci for inflammatory bowel disease, mostly shared between Crohn's disease and ulcerative colitis. We undertook the largest genotype association study, to date, in widely used clinical subphenotypes of inflammatory bowel disease with the goal of further understanding the biological relations between diseases.Methods: This study included patients from 49 centres in 16 countries in Europe, North America, and Australasia. We applied the Montreal classification system of inflammatory bowel disease subphenotypes to 34 819 patients (19 713 with Crohn's disease, 14 683 with ulcerative colitis) genotyped on the Immunochip array. We tested for genotype–phenotype associations across 156 154 genetic variants. We generated genetic risk scores by combining information from all known inflammatory bowel disease associations to summarise the total load of genetic risk for a particular phenotype. We used these risk scores to test the hypothesis that colonic Crohn's disease, ileal Crohn's disease, and ulcerative colitis are all genetically distinct from each other, and to attempt to identify patients with a mismatch between clinical diagnosis and genetic risk profile.Findings: After quality control, the primary analysis included 29 838 patients (16 902 with Crohn's disease, 12 597 with ulcerative colitis). Three loci (NOD2, MHC, and MST1 3p21) were associated with subphenotypes of inflammatory bowel disease, mainly disease location (essentially fixed over time; median follow-up of 10·5 years). Little or no genetic association with disease behaviour (which changed dramatically over time) remained after conditioning on disease location and age at onset. The genetic risk score representing all known risk alleles for inflammatory bowel disease showed strong association with disease subphenotype (p=1·65 × 10−78), even after exclusion of NOD2, MHC, and 3p21 (p=9·23 × 10−18). Predictive models based on the genetic risk score strongly distinguished colonic from ileal Crohn's disease. Our genetic risk score could also identify a small number of patients with discrepant genetic risk profiles who were significantly more likely to have a revised diagnosis after follow-up (p=6·8 × 10−4).Interpretation: Our data support a continuum of disorders within inflammatory bowel disease, much better explained by three groups (ileal Crohn's disease, colonic Crohn's disease, and ulcerative colitis) than by Crohn's disease and ulcerative colitis as currently defined. Disease location is an intrinsic aspect of a patient's disease, in part genetically determined, and the major driver to changes in disease behaviour over time.Funding: International Inflammatory Bowel Disease Genetics Consortium members funding sources (see Acknowledgments for full list).

Published
2016

47. Evaluation of Convalescent Plasma for Ebola Virus Disease in Guinea

Author

van Griensven, J, Edwards, T, de Lamballerie, X, Semple, MG, Gallian, P, Baize, S, Horby, PW, Raoul, H, Magassouba, N, Antierens, A, Lomas, C, Faye, O, Sall, AA, Fransen, K, Buyze, J, Ravinetto, R, Tiberghien, P, Claeys, Y, De Crop, M, Lynen, L, Bah, EI, Smith, PG, Delamou, A, De Weggheleire, A, Haba, N, Ebola-Tx Consortium, COLLABORATORS, Camara, BS, Olivier, KJ, Ballo, Y, Sakoba, K, Konde, K, Colebunders, R, Muyembe, JJ, Menten, J, Alexander, N, Van Den Broecke, S, Custers, A, Temmerman, S, Ingelbeen, B, Arango, D, Crucitti, T, Jacobs, J, Cuylaerts, V, Vermoessen, T, Ronse, M, Saez, AM, Bigey, F, Briki, M, Chambe, E, Chavarin, P, Devillers, M, Gauthier, M, Guillard, A, Isola, H, Jacquot, C, Lardin, B, Lavedrine, V, Lazaygues, C, Van de Kerckhove, P, Gueguen, M, Jonckheere, S, and Andersen, HB

Abstract

In the wake of the recent outbreak of Ebola virus disease (EVD) in several African countries, the World Health Organization prioritized the evaluation of treatment with convalescent plasma derived from patients who have recovered from the disease. We evaluated the safety and efficacy of convalescent plasma for the treatment of EVD in Guinea. : In this nonrandomized, comparative study, 99 patients of various ages (including pregnant women) with confirmed EVD received two consecutive transfusions of 200 to 250 ml of ABO-compatible convalescent plasma, with each unit of plasma obtained from a separate convalescent donor. The transfusions were initiated on the day of diagnosis or up to 2 days later. The level of neutralizing antibodies against Ebola virus in the plasma was unknown at the time of administration. The control group was 418 patients who had been treated at the same center during the previous 5 months. The primary outcome was the risk of death during the period from 3 to 16 days after diagnosis with adjustments for age and the baseline cycle-threshold value on polymerase-chain-reaction assay; patients who had died before day 3 were excluded. The clinically important difference was defined as an absolute reduction in mortality of 20 percentage points in the convalescent-plasma group as compared with the control group. : A total of 84 patients who were treated with plasma were included in the primary analysis. At baseline, the convalescent-plasma group had slightly higher cycle-threshold values and a shorter duration of symptoms than did the control group, along with a higher frequency of eye redness and difficulty in swallowing. From day 3 to day 16 after diagnosis, the risk of death was 31% in the convalescent-plasma group and 38% in the control group (risk difference, -7 percentage points; 95% confidence interval [CI], -18 to 4). The difference was reduced after adjustment for age and cycle-threshold value (adjusted risk difference, -3 percentage points; 95% CI, -13 to 8). No serious adverse reactions associated with the use of convalescent plasma were observed. : The transfusion of up to 500 ml of convalescent plasma with unknown levels of neutralizing antibodies in 84 patients with confirmed EVD was not associated with a significant improvement in survival. (Funded by the European Union's Horizon 2020 Research and Innovation Program and others; ClinicalTrials.gov number, NCT02342171.).

Published
2016

48. Transmission of HIV drug resistance and the predicted effect on current first-line regimens in Europe

Author

Hofstra, L.M. Sauvageot, N. Albert, J. Alexiev, I. Garcia, F. Struck, D. Van De Vijver, D.A.M.C. Åsjö, B. Beshkov, D. Coughlan, S. Descamps, D. Griskevicius, A. Hamouda, O. Horban, A. Van Kasteren, M. Kolupajeva, T. Kostrikis, L.G. Liitsola, K. Linka, M. Mor, O. Nielsen, C. Otelea, D. Paraskevis, D. Paredes, R. Poljak, M. Puchhammer-Stöckl, E. Sönnerborg, A. Staneková, D. Stanojevic, M. Van Laethem, K. Zazzi, M. Lepej, S.Z. Boucher, C.A.B. Schmit, J.-C. Wensing, A.M.J. Puchhammer-Stockl, E. Sarcletti, M. Schmied, B. Geit, M. Balluch, G. Vandamme, A.-M. Vercauteren, J. Derdelinckx, I. Sasse, A. Bogaert, M. Ceunen, H. De Roo, A. De Wit, S. Echahidi, F. Fransen, K. Goffard, J.-C. Goubau, P. Goudeseune, E. Yombi, J.-C. Lacor, P. Liesnard, C. Moutschen, M. Pierard, D. Rens, R. Schrooten, Y. Vaira, D. Vandekerckhove, L.P.R. Van Den Heuvel, A. Van Der Gucht, B. Van Ranst, M. Van Wijngaerden, E. Vandercam, B. Vekemans, M. Verhofstede, C. Clumeck, N. Begovac, J. Demetriades, I. Kousiappa, I. Demetriou, V. Hezka, J. Maly, M. Machala, L. Jørgensen, L.B. Gerstoft, J. Mathiesen, L. Pedersen, C. Nielsen, H. Laursen, A. Kvinesdal, B. Ristola, M. Suni, J. Sutinen, J. Assoumou, L. Castor, G. Grude, M. Flandre, P. Storto, A. Kücherer, C. Berg, T. Braun, P. Poggensee, G. Däumer, M. Eberle, J. Heiken, H. Kaiser, R. Knechten, H. Korn, K. Müller, H. Neifer, S. Schmidt, B. Walter, H. Gunsenheimer-Bartmeyer, B. Harrer, T. Hatzakis, A. Zavitsanou, A. Vassilakis, A. Lazanas, M. Chini, M. Lioni, A. Sakka, V. Kourkounti, S. Paparizos, V. Antoniadou, A. Papadopoulos, A. Poulakou, G. Katsarolis, I. Protopapas, K. Chryssos, G. Drimis, S. Gargalianos, P. Xylomenos, G. Lourida, G. Psichogiou, M. Daikos, G.L. Sipsas, N.V. Kontos, A. Gamaletsou, M.N. Koratzanis, G. Sambatakou, E. Mariolis, H. Skoutelis, A. Papastamopoulos, V. Georgiou, O. Panagopoulos, P. Maltezos, E. De Gascun, C. Byrne, C. Duffy, M. Bergin, C. Reidy, D. Farrell, G. Lambert, J. O'Connor, E. Rochford, A. Low, J. Coakely, P. O'Dea, S. Hall, W. Levi, I. Chemtob, D. Grossman, Z. De Luca, A. Balotta, C. Riva, C. Mussini, C. Caramma, I. Capetti, A. Colombo, M.C. Rossi, C. Prati, F. Tramuto, F. Vitale, F. Ciccozzi, M. Angarano, G. Rezza, G. Vasins, O. Lipnickiene, V. Hemmer, R. Arendt, V. Michaux, C. Staub, T. Sequin-Devaux, C. Van Kessel, A. Van Bentum, P.H.M. Brinkman, K. Connell, B.J. Van Der Ende, M.E. Hoepelman, I.M. Kuipers, M. Langebeek, N. Richter, C. Santegoets, R.M.W.J. Schrijnders-Gudde, L. Schuurman, R. Van De Ven, B.J.M. Kran, A.-M.B. Ormaasen, V. Aavitsland, P. Stanczak, J.J. Stanczak, G.P. Firlag-Burkacka, E. Wiercinska-Drapalo, A. Jablonowska, E. Maolepsza, E. Leszczyszyn-Pynka, M. Szata, W. Camacho, R. Palma, C. Borges, F. Paixão, T. Duque, V. Araújo, F. Paraschiv, S. Tudor, A.M. Cernat, R. Chiriac, C. Dumitrescu, F. Prisecariu, L.J. Jevtovic, Dj. Salemovic, D. Stanekova, D. Habekova, M. Chabadová, Z. Drobkova, T. Bukovinova, P. Shunnar, A. Truska, P. Lunar, M. Babic, D. Tomazic, J. Vidmar, L. Vovko, T. Karner, P. Monge, S. Moreno, S. Del Amo, J. Asensi, V. Sirvent, J.L. De Mendoza, C. Delgado, R. Gutiérrez, F. Berenguer, J. Garcia-Bujalance, S. Stella, N. De Los Santos, I. Blanco, J.R. Dalmau, D. Rivero, M. Segura, F. Elías, M.J.P. Alvarez, M. Chueca, N. Rodríguez-Martín, C. Vidal, C. Palomares, J.C. Viciana, I. Viciana, P. Cordoba, J. Aguilera, A. Domingo, P. Galindo, M.J. Miralles, C. Del Pozo, M.A. Ribera, E. Iribarren, J.A. Ruiz, L. De La Torre, J. Vidal, F. Clotet, B. Heidarian, A. Aperia-Peipke, K. Axelsson, M. Mild, M. Karlsson, A. Thalme, A. Navér, L. Bratt, G. Blaxhult, A. Gisslén, M. Svennerholm, B. Björkman, P. Säll, C. Mellgren, Å. Lindholm, A. Kuylenstierna, N. Montelius, R. Azimi, F. Johansson, B. Carlsson, M. Johansson, E. Ljungberg, B. Ekvall, H. Strand, A. Mäkitalo, S. Öberg, S. Holmblad, P. Höfer, M. Holmberg, H. Josefson, P. Ryding, U. Bergbrant, I. SPREAD Program

Abstract

Background. Numerous studies have shown that baseline drug resistance patterns may influence the outcome of antiretroviral therapy. Therefore, guidelines recommend drug resistance testing to guide the choice of initial regimen. In addition to optimizing individual patient management, these baseline resistance data enable transmitted drug resistance (TDR) to be surveyed for public health purposes. The SPREAD program systematically collects data to gain insight into TDR occurring in Europe since 2001. Methods. Demographic, clinical, and virological data from 4140 antiretroviral-naive human immunodeficiency virus (HIV)-infected individuals from 26 countries who were newly diagnosed between 2008 and 2010 were analyzed. Evidence of TDR was defined using the WHO list for surveillance of drug resistance mutations. Prevalence of TDR was assessed over time by comparing the results to SPREAD data from 2002 to 2007. Baseline susceptibility to antiretroviral drugs was predicted using the Stanford HIVdb program version 7.0. Results. The overall prevalence of TDR did not change significantly over time and was 8.3% (95% confidence interval, 7.2%-9.5%) in 2008-2010. The most frequent indicators of TDR were nucleoside reverse transcriptase inhibitor (NRTI) mutations (4.5%), followed by nonnucleoside reverse transcriptase inhibitor (NNRTI) mutations (2.9%) and protease inhibitor mutations (2.0%). Baseline mutations were most predictive of reduced susceptibility to initial NNRTI-based regimens: 4.5% and 6.5% of patient isolates were predicted to have resistance to regimens containing efavirenz or rilpivirine, respectively, independent of current NRTI backbones. Conclusions. Although TDR was highest for NRTIs, the impact of baseline drug resistance patterns on susceptibility was largest for NNRTIs. The prevalence of TDR assessed by epidemiological surveys does not clearly indicate to what degree susceptibility to different drug classes is affected. © The Author 2015.

Published
2016

49. On-site geometrical measurements of an experimental ice composite shell through TLS and photogrammetry

Author

Deruyter, G., Fransen, K., Glas, H., Belis, J.L.I.F., and Cruz, P.J.S.

Abstract

Measurement techniques for determining the thickness and shape of ice structures can be divided into contact and non-contact methods. The non-contact methods are the most appropriate for measuring relatively thin fiber reinforced ice shells because they hold no risk for damages. Furthermore, these measurement techniques can be repeated during the icing process, which, additionally, enables to produce intermediate results. This paper describes the 3D measurement and modelling methods used for the “Candela pavilion” that was built by university students and staff in the framework of an international project in Juuka, Finland during the winter of early 2016.

Published
2016

50. Transmission of HIV Drug Resistance and the Predicted Effect on Current First-line Regimens in Europe

Author

Moutschen, M., Hofstra, Laura Marije Arije, Sauvageot, Nicolas, Albert, Jan, Alexiev, Ivailo, Garcia, Federico, Struck, Daniel, Van, de Vijver, Åsjö, Birgitta, Beshkov, Danail, Coughlan, Suzie, Descamps, Diane, Griskevicius, Algirdas, Hamouda, Osamah, Horban, Andrzej, Van Kasteren, Marjo, Kolupajeva, Tatjana, Kostrikis, Leontios G., Liitsola, Kirsi, Linka, Marek, Mor, Orna, Nielsen, Claus, Otelea, Dan, Paraskevis, Dimitrios N., Paredes, Roger, Poljak, Mario, Puchhammer-Stöckl, Elisabeth, Sönnerborg, Anders, Staneková, Danica, Stanojevic, Maja, Van Laethem, Kristel, Zazzi, Maurizio, Zidovec Lepej, Snjezana, Boucher, Charles A. B., Schmit, Jean-Claude, Wensing, Annemarie M. J., Puchhammer-Stockl, E., Sarcletti, M., Schmied, B., Geit, M., Balluch, G., Vandamme, A. M., Vercauteren, J., Derdelinckx, I., Sasse, A., Bogaert, M., Ceunen, H., De Roo, A., De Wit, S., Echahidi, F., Fransen, K., Goffard, J. -C, Goubau, P., Goudeseune, E., Yombi, J. -C, Lacor, P., Liesnard, C., Pierard, D., Rens, R., Schrooten, Y., Vaira, D., Vandekerckhove, L. P. R., Van, den Heuvel, Van, Der Gucht, Van Ranst, M., Van Wijngaerden, E., Vandercam, B., Vekemans, M., Verhofstede, C., Clumeck, N., Van Laethem, K., Lepej, S. Z., Begovac, J., Demetriades, Ioannis, Kousiappa, Ioanna, Demetriou, Victoria L., Hezka, Johana, Linka, M., Maly, M., Machala, L., Nielsen, C., Jørgensen, L. B., Gerstoft, J., Mathiesen, L., Pedersen, C., Nielsen, H., Laursen, A., Kvinesdal, B., Liitsola, K., Ristola, M., Suni, J., Sutinen, J., Descamps, D., Assoumou, L., Castor, G., Grude, M., Flandre, P., Storto, A., Hamouda, O., Kücherer, C., Berg, T., Braun, P., Poggensee, G., Däumer, M., Eberle, J., Heiken, H., Kaiser, R., Knechten, H., Korn, K., Müller, H., Neifer, S., Schmidt, B., Walter, H., Gunsenheimer-Bartmeyer, B., Harrer, T., Hatzakis, Angelos E., Zavitsanou, Assimina, Vassilakis, A., Lazanas, Marios C., Chini, Maria C., Lioni, A., Sakka, V., Kourkounti, Sofia, Paparizos, Vassilios A., Antoniadou, Anastasia C., Papadopoulos, Antonios I., Poulakou, Garyphallia G., Katsarolis, I., Protopapas, K., Chryssos, Georgios, Drimis, Stylianos, Gargalianos, Panagiotis, Xylomenos, Georgios, Lourida, G., Psichogiou, Mina A., Daikos, George L., Sipsas, N. V., Kontos, Athanasios N., Gamaletsou, M. N., Koratzanis, Georgios, Sambatakou, H., Mariolis, H., Skoutelis, A., Papastamopoulos, V., Georgiou, O., Panagopoulos, Periklis, Maltezos, E., Coughlan, S., De Gascun, C., Byrne, C., Duffy, M., Bergin, C., Reidy, D., Farrell, G., Lambert, J., O'Connor, E., Rochford, A., Low, J., Coakely, P., O'Dea, S., Hall, W., Mor, O., Levi, I., Chemtob, D., Grossman, Z., Zazzi, M., de Luca, A., Balotta, Claudia, Riva, C., Mussini, C., Caramma, I., Capetti, A., Colombo, M. C., Rossi, C., Prati, F., Tramuto, F., Vitale, F., Ciccozzi, M., Angarano, G., Rezza, G., Kolupajeva, T., Vasins, O., Griskevicius, A., Lipnickiene, V., Schmit, J. C., Struck, D., Hemmer, R., Arendt, V., Michaux, C., Staub, T., Sequin-Devaux, C., Wensing, A. M. J., Boucher, C. A. B., van, de Vijver, van Kessel, A., van Bentum, P. H. M., Brinkman, K., Connell, B. J., van, der Ende, Hoepelman, I. M., van Kasteren, M., Kuipers, M., Langebeek, N., Richter, C., Santegoets, R. M. W. J., Schrijnders-Gudde, L., Schuurman, R., van, de Ven, Kran, A. -M B., Ormaasen, V., Aavitsland, P., Horban, A., Stanczak, J. J., Stanczak, G. P., Firlag-Burkacka, E., Wiercinska-Drapalo, A., Jablonowska, E., Maolepsza, E., Leszczyszyn-Pynka, M., Szata, W., Camacho, Ricardo J., Palma, C., Borges, F., Paixão, T., Duque, V., Araújo, F., Otelea, D., Paraschiv, S., Tudor, A. M., Cernat, R., Chiriac, C., Dumitrescu, F., Prisecariu, L. J., Stanojevic, M., Jevtovic, Dj, Salemovic, D., Stanekova, D., Habekova, M., Chabadová, Z., Drobkova, T., Bukovinova, P., Shunnar, A., Truska, P., Poljak, M., Lunar, M., Babic, Dunja Z., Tomazic, J., Vidmar, L., Vovko, T., Karner, P., Garcia, F., Paredes, R., Monge, S., Moreno, S., del Amo, J., Asensi, V., Sirvent, J. L., de Mendoza, C., Delgado, R., Gutiérrez, F., Berenguer, J., Garcia-Bujalance, S., Stella, Natalia C., de, los Santos, Blanco, J. R., Dalmau, D., Rivero, M., Segura, F., Elıás, Marıá Jesús Pérez, Alvarez, M., Chueca, N., Rodríguez-Martín, C., Vidal, C., Palomares, J. C., Viciana, I., Viciana, P., Cordoba, J., Aguilera, A., Domingo, P., Galindo, M. J., Miralles, C., del Pozo, M. A., Ribera, E., Iribarren, J. A., Ruiz, L., de, la Torre, Vidal, F., Clotet, B., Heidarian, A., Aperia-Peipke, K., Axelsson, M., Mild, M., Karlsson, A., Sönnerborg, A., Thalme, A., Navér, L., Bratt, G., Blaxhult, A., Gisslén, M., Svennerholm, B., Bergbrant, I., Björkman, Per, Säll, C., Mellgren, Å., Lindholm, A., Kuylenstierna, N., Montelius, R., Azimi, F., Johansson, B., Carlsson, M., Johansson, E., Ljungberg, B., Ekvall, H., Strand, A., Mäkitalo, S., Öberg, S., Holmblad, P., Höfer, M., Holmberg, H., Josefson, P., Ryding, U., Van Kessel, A., Clinical sciences, Microbiology and Infection Control, Supporting clinical sciences, Clinicum, Department of Medicine, Virology, Cohorte de Adultos de la Red de Investigación en SIDA, Spain., SPREAD Program, [Hofstra,LM, Sauvageot,N, Struck,D, Schmit,JC ] Luxembourg Institute of Health, Luxembourg. [Hofstra,LM, Wensing,AMJ] Department of Virology, University Medical Center Utrecht, The Netherlands. [Albert,J, Sönnerborg,A] Karolinska Institute, Solna. Karolinska University Hospital, Stockholm, Sweden. [Alexiev,I, Beshkov,D] National Center of Infectious and Parasitic Diseases, Sofia, Bulgaria. [Garcia,F] Complejo Hospitalario Universitario de Granada. Instituto de Investigación IBS Granada, Spain. [Van de Vijver,DAMC, Boucher,CAB] Erasmus MC, University Medical Center, Rotterdam, The Netherlands. [Åsjö,B] University of Bergen, Norway. [Coughlan,S] University College Dublin, Ireland. [Descamps,D] AP-HP Groupe hospitalier Bichat-Claude Bernard. IAME INSERM UMR 1137. Université Paris Diderot Sorbonne Paris Cité, Paris, France. [Griskevicius,A] Lithuanian AIDS Center, Vilnius, Lithuania. [Hamouda,O] Robert Koch Institute, Berlin, Germany. [Horban,A] Hospital of Infectious Diseases, Warsaw, Poland. [Van Kasteren,M] St Elisabeth Hospital, Tilburg, The Netherlands. [Kolupajeva,T] Infectiology Center of Latvia, Riga. [Kostrikis,LG] University of Cyprus, Nicosia. [Liitsola,K] Department of Infectious Diseases, National Institute for Health and Welfare, Helsinki, Finland. [Linka,M] National Reference Laboratory for HIV/AIDS, National Institute of Public Health, Prague, Czech Republic. [Mor,O] National HIV Reference Laboratory, Chaim Sheba Medical Center, Tel-Hashomer, Israel. [Nielsen,C] Statens Serum Institut, Copenhagen, Denmark. [Otelea,D] National Institute for Infectious Diseases 'Prof. dr. Matei Bals', Bucharest, Romania. [Paraskevis,D] National Retrovirus Reference Center, University of Athens, Greece. [Paredes,R] IrsiCaixa Foundation, Badalona, Spain. [Poljak,M] Faculty of Medicine, Slovenian HIV/AIDS Reference Centre, University of Ljubljana, Slovenia. [Puchhammer-Stöckl,E] Medical University Vienna, Austria. [Staneková,D] Slovak Medical University, Bratislava, Slovakia. [Stanojevic,M] Faculty of Medicine, University of Belgrade, Serbia. [Van Laethem,K] Rega Institute for Medical Research, KU Leuven, Belgium. [Zazzi,M] University of Siena, Italy. [Zidovec Lepej,S] University Hospital for Infectious Diseases 'Dr. Fran Mihaljevic', Zagreb, Croatia., This work was supported by a CORE grant of Fond National de la Recherche Luxembourg (grant number C12/BM/4011111–HIV molecular epidemiology in Europe). This work has been partially supported by the European Commission (fifth framework, grant number QLK2-CT-2001-01344, sixth framework, grant number LSHP-CT-2006-518211, DynaNets grant number 233847, seventh framework, CHAIN grant number 223131), Belgium: Belgian AIDS Reference Laboratory Fund, Belgian Fonds voor Wetenschappelijk Onderzoek (grant number G.0692.14), Cyprus: Cyprus Research Promotion Foundation (grant number Health/0104/22), Denmark: Danish AIDS Foundation, France: Agence Nationale de Recherches sur le SIDA et les Hepatites Virales, Germany: Ministry of Health (grant number 1502-686-18), Ministry of Education and Research (grant number 01KI501), Italy: Fifth National Program on HIV/AIDS, Instituto Superiore di Sanità (grant numbers 40F.56 and 20D.1.6), Luxembourg: Fondation Recherche sur le SiDA and Ministry of Health, Republic of Serbia: Ministry of Education and Science (grant number 175024), Slovakia: project 'Center of Excellence of Environmental Health,' ITMS number 26240120033, based on supporting operational research and development program financed from the European Regional Development Fund, and Sweden: Swedish Research Council and Swedish Civil Contingencies Agency., APH - Health Behaviors & Chronic Diseases, Graduate School, Hofstra, LM, Sauvageot, N, Albert, J, Alexiev, I, Garcia, F, Struck, D, Van de Vijver, DA, Åsjö, B, Beshkov, D, Coughlan, S, Descamps, D, Griskevicius, A, Hamouda, O, Horban, A, Van Kasteren, M, Kolupajeva, T, Kostrikis, LG, Liitsola, K, Linka, M, Mor, O, Nielsen, C, Otelea, D, Paraskevis, D, Paredes, R, Poljak, M, Puchhammer-Stöckl, E, Sönnerborg, A, Staneková, D, Stanojevic, M, Van Laethem, K, Zazzi, M, Lepej, SZ, Boucher, CA, Schmit, JC, Wensing, AM, SPREAD program investigators, including Vitale F and Tramuto, F, Vandamme, Annemie, Vercauteren, Jurgen, Schrooten, Yoeri, Van Ranst, Marc, Van Wijngaerden, Eric, Derdelinckx, Inge, Camacho, Ricardo Jorge, Kostrikis, Leontios G. [0000-0002-5340-7109], and Paraskevis, Dimitrios [0000-0001-6167-7152]

Subjects
Male, Human immunodeficiency virus 1, Etravirine, RNA directed DNA polymerase inhibitor, darunavir, HIV Infections, Settore MED/42 - Igiene Generale E Applicata, Disciplines and Occupations::Health Occupations::Medicine::Public Health [Medical Subject Headings], Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Salud pública, genetics, Inhibidores de proteasas, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::Prevalence [Medical Subject Headings], atazanavir, media_common, transmission, Geographicals::Geographic Locations::Europe [Medical Subject Headings], 3. Good health, microbial sensitivity test, priority journal, Europe, HIV-1, antiretroviral therapy, drug resistance, HIV/AIDS, lamivudine, Reverse Transcriptase Inhibitors/pharmacology, anti human immunodeficiency virus agent, Drug, Microbiology (medical), medicine.medical_specialty, antiviral susceptibility, Phenomena and Processes::Genetic Phenomena::Genetic Variation::Mutation [Medical Subject Headings], media_common.quotation_subject, 030106 microbiology, HIV Infections/drug therapy, Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents::Antiviral Agents::Anti-Retroviral Agents::Reverse Transcriptase Inhibitors [Medical Subject Headings], Microbial Sensitivity Tests, RILPIVIRINE, Article, EFAVIRENZ, 03 medical and health sciences, transmitted drug resistance, SDG 3 - Good Health and Well-being, Humans, Transmission, human, Phenomena and Processes::Physiological Phenomena::Pharmacological Phenomena::Drug Resistance [Medical Subject Headings], REVERSE-TRANSCRIPTASE INHIBITORS, Rilpivirina, INTEGRASE, MUTATIONS, abacavir, major clinical study, Virology, Infecciones por VIH, Regimen, Antiretroviral therapy, Drug resistance, Medicine (all), Infectious Diseases, chemistry, Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 1-Ring::Oxazines::Benzoxazines [Medical Subject Headings], Mutation, 0301 basic medicine, nevirapine, Communicable diseases, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Confidence Intervals [Medical Subject Headings], chemistry.chemical_compound, antiviral therapy, INFECTION, Medicine and Health Sciences, Prevalence, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Surveys and Questionnaires [Medical Subject Headings], Viral, Non-U.S. Gov't, Reverse-transcriptase inhibitor, antiretrovirus agent, Research Support, Non-U.S. Gov't, Human immunodeficiency virus infected patient, Middle Aged, virology, PREVALENCE, Encuestas y Cuestionarios, ANTIRETROVIRAL TREATMENT, HIV-1/drug effects, HIV Protease Inhibitors/pharmacology, Rilpivirine, Reverse Transcriptase Inhibitors, Diseases::Immune System Diseases::Immunologic Deficiency Syndromes::HIV Infections [Medical Subject Headings], Female, HIV drug resistance, medicine.drug, Adult, Human immunodeficiency virus proteinase inhibitor, Chemicals and Drugs::Organic Chemicals::Nitriles::Rilpivirine [Medical Subject Headings], Efavirenz, Anti-HIV Agents, Research Support, Resistencia a medicamentos, Settore MED/17 - MALATTIE INFETTIVE, antiviral resistance, Internal medicine, Anti-HIV Agents/pharmacology, Drug Resistance, Viral, Journal Article, medicine, Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Enzyme Inhibitors::Protease Inhibitors [Medical Subject Headings], abacavir plus lamivudine, Europa (Continente), HIV Protease Inhibitors, emtricitabine, nonhuman, Intervalos de confianza, Mutación, business.industry, HIV, prediction, Inhibidores de la transcriptasa inversa, Human immunodeficiency virus 1 infection, tenofovir, INDIVIDUALS, Drug Resistance, Viral/genetics, Benzoxazinas, ETRAVIRINE, drug effects, 3121 General medicine, internal medicine and other clinical medicine, Prevalencia, business
Abstract

Transmitted human immunodeficiency virus drug resistance in Europe is stable at around 8%. The impact of baseline mutation patterns on susceptibility to antiretroviral drugs should be addressed using clinical guidelines. The impact on baseline susceptibility is largest for nonnucleoside reverse transcriptase inhibitors., Background. Numerous studies have shown that baseline drug resistance patterns may influence the outcome of antiretroviral therapy. Therefore, guidelines recommend drug resistance testing to guide the choice of initial regimen. In addition to optimizing individual patient management, these baseline resistance data enable transmitted drug resistance (TDR) to be surveyed for public health purposes. The SPREAD program systematically collects data to gain insight into TDR occurring in Europe since 2001. Methods. Demographic, clinical, and virological data from 4140 antiretroviral-naive human immunodeficiency virus (HIV)–infected individuals from 26 countries who were newly diagnosed between 2008 and 2010 were analyzed. Evidence of TDR was defined using the WHO list for surveillance of drug resistance mutations. Prevalence of TDR was assessed over time by comparing the results to SPREAD data from 2002 to 2007. Baseline susceptibility to antiretroviral drugs was predicted using the Stanford HIVdb program version 7.0. Results. The overall prevalence of TDR did not change significantly over time and was 8.3% (95% confidence interval, 7.2%–9.5%) in 2008–2010. The most frequent indicators of TDR were nucleoside reverse transcriptase inhibitor (NRTI) mutations (4.5%), followed by nonnucleoside reverse transcriptase inhibitor (NNRTI) mutations (2.9%) and protease inhibitor mutations (2.0%). Baseline mutations were most predictive of reduced susceptibility to initial NNRTI-based regimens: 4.5% and 6.5% of patient isolates were predicted to have resistance to regimens containing efavirenz or rilpivirine, respectively, independent of current NRTI backbones. Conclusions. Although TDR was highest for NRTIs, the impact of baseline drug resistance patterns on susceptibility was largest for NNRTIs. The prevalence of TDR assessed by epidemiological surveys does not clearly indicate to what degree susceptibility to different drug classes is affected.

Published
2016

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