20 results on '"Frankum, B"'
Search Results
2. Tocilizumab for severe COVID-19 pneumonia: Case series of 5 Australian patients.
- Author
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Keat K., Ojaimi S., Tran T., West T.A., Malik S., Nalpantidis A., Cannon C., Bhonagiri D., Chan K., Cheong E., Wan Sai Cheong J., Cheung W., Choudhury F., Ernest D., Farah C.S., Fernando S., Kanapathipillai R., Kol M., Murfin B., Naqvi H., Shah A., Wagh A., Frankum B., Riminton S., Keat K., Ojaimi S., Tran T., West T.A., Malik S., Nalpantidis A., Cannon C., Bhonagiri D., Chan K., Cheong E., Wan Sai Cheong J., Cheung W., Choudhury F., Ernest D., Farah C.S., Fernando S., Kanapathipillai R., Kol M., Murfin B., Naqvi H., Shah A., Wagh A., Frankum B., and Riminton S.
- Abstract
Aim: To describe the first Australian cases of severe acute respiratory syndrome-coronavirus 2 (SARS-CoV2) disease (COVID-19) pneumonia treated with the interleukin-6 receptor antagonist tocilizumab. Method(s): Retrospective, open-label, real-world, uncontrolled, single-arm case series conducted in 2 tertiary hospitals in NSW, Australia and 1 tertiary hospital in Victoria, Australia. Five adult male patients aged between 46 and 74 years with type 1 respiratory failure due to COVID-19 pneumonia requiring intensive care unit (ICU) admission and biochemical evidence of systemic hyperinflammation (C-reactive protein greater than 100 mg/L; ferritin greater than 700 mug/L) were administered variable-dose tocilizumab. Result(s): At between 13 and 26 days follow-up, all patients are alive and have been discharged from ICU. Two patients have been discharged home. Two patients avoided endotracheal intubation. Oxygen therapy has been ceased in three patients. Four adverse events potentially associated with tocilizumab therapy occurred in three patients: ventilator-associated pneumonia, bacteremia associated with central venous catheterization, myositis and hepatitis. All patients received broad-spectrum antibiotics, 4 received corticosteroids and 2 received both lopinavir/ritonavir and hydroxychloroquine. The time from first tocilizumab administration to improvement in ventilation, defined as a 25% reduction in fraction of inspired oxygen required to maintain peripheral oxygen saturation greater than 92%, ranged from 7 hours to 4.6 days. Conclusion(s): Tocilizumab use was associated with favorable clinical outcome in our patients. We recommend tocilizumab be included in randomized controlled trials of treatment for patients with severe COVID-19 pneumonia, and be considered for compassionate use in such patients pending the results of these trials.Copyright © 2020 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd
- Published
- 2020
3. The Correlation Between Atopic Dermatitis Disease Severity and Quality of Life is Complex: 153
- Author
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Lewer, F. C., Keat, K., Burton, P. K., Frankum, B. S., Wainstein, B., and Katelaris, C. H.
- Published
- 2011
4. Long-Term Outcomes with Subcutaneous C1-Inhibitor Replacement Therapy for Prevention of Hereditary Angioedema Attacks
- Author
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Zuraw, B, Katelaris, C, Sussman, G, Keith, PK, Yang, W, Hebert, J, Hanzlikova, J, Staubach-Renz, P, Martinez-Saguer, I, Magerl, M, Aygoren-Pursun, E, Farkas, H, Reshef, A, Kivity, S, Neri, S, Crisan, I, Caballero, T, Baeza, ML, Hernandez, MD, Li, H, Lumry, W, Bernstein, JA, Hussain, I, Anderson, J, Schwartz, LB, Jacobs, J, Manning, M, Levy, D, Riedl, M, Christiansen, S, Zuraw, BL, Cicardi, M, Craig, T, Longhurst, H, Grattan, C, Bork, K, Kreuz, W, Jacobs, I, Pragst, I, Herget, S, Dalton, S, Clement, C, Mycroft, S, Pawaskar, D, Zhang, Y, Machnig, T, Waldhauser, H, Feuersenger, H, Lawo, JP, Lang, D, Hoernlein, S, Mildenberger, M, Foeller, K, Ellis, F, Wood, D, Walsh, M, Qu, QL, Mueller-Stark, K, Feussner, A, Kalina, U, Ma, X, Rigsby, S, Scheffler, E, Fischer, JF, Kolb, C, Katelaris, CH, Frankum, B, Keat, K, Philip, B, Lee, JA, Urriola, N, Lee, MW, Sussman, GL, Levi, G, Gould, W, Ferrie, P, Rosenberg, E, Waserman, S, O'Quinn, J, Gagnon, R, Vachova, M, Stauerbach-Renz, P, Weber, A, Zimmer, S, Gilfert, T, Lang, B, Escuriola-Ettingshausen, C, Maurer, M, Metz, M, Schoepke, N, Altrichter, S, Hawro, T, Schwabe, D, Graff, J, Behrens, F, Kohm, M, Andarawewa, S, Temesszentandrasi, G, Kohalmi, VK, Kidon, M, Kadar, L, Benor, S, Bonanni, E, Wu, M, Zanichelli, A, Mansi, M, Rizzotto, A, Giardino, F, Fidone, F, Varga, M, Iftene, M, Badiu-Tisa, ID, Cabanas, R, Pedrosa, M, Rivero-Paparoni, D, Gomez-Traseira, C, Alvez, A, Phillips, E, Prieto, A, Zubeldia, J, Ibanez, E, Almero, R, Buckland, M, Grigoriadou, S, Manson, A, Yeatman, N, Laffan, J, Nasr, I, Ghurye, R, Rehman, T, Schaeffer, C, Ghaffari, G, Kelbel, T, Reddy, V, Buyantseva, L, Mende, C, Jose, J, Novchicht, T, Li, HH, Scarupa, M, Economides, A, White, M, Kaliner, M, Ward, C, Shaikh, S, Johnson, T, Kosh, L, Dauphin, P, Baker, J, Persons, S, Newman, A, Noonan, MJ, Lumry, WR, Poarch, KP, Tucker, J, Aguilar, D, Noth, D, Bernstein, J, Bernstein, D, Evans, S, Crawford, M, McGuckin, SD, McCollum, JR, Bradley, B, Wagner, C, Cartwright, A, Bonner, J, Soong, W, Sikora, M, Lemke, M, Luthin, P, Youngblood, B, DeBerry, E, Gilbert, E, Zhao, W, Ward, B, Alvarez, A, Kumar, S, Akl, E, Curl, J, Silva, K, Mostofi, T, Schultz, N, Manning, ME, Davis, A, Nelson, J, Levy, DS, Christiansen, SC, and COMPACT Investigators
- Subjects
Hereditary angioedema ,HAEGARDA ,Long-term ,Prophylaxis ,Subcutaneous ,Safety ,C1-esterase inhibitor - Abstract
BACKGROUND: For the prevention of attacks of hereditary angioedema (HAE), the efficacy and safety of subcutaneous human C1-esterase inhibitor (C1-INH [SC]; HAEGARDA, CSL Behring) was established in the 16-week Clinical Study for Optimal Management of Preventing Angioedema with Low-Volume Subcutaneous C1-Inhibitor Replacement Therapy (COMPACT). OBJECTIVE: To assess the long-term safety, occurrence of angioedema attacks, and use of rescue medication with C1-INH(SC). METHODS: Open-label, randomized, parallel-arm extension of COMPACT across 11 countries. Patients with frequent angioedema attacks, either study treatment-naive or who had completed COMPACT, were randomly assigned (1:1) to 40 IU/ kg or 60 IU/kg C1-INH(SC) twice per week, with conditional uptitration to optimize prophylaxis (ClinicalTrials.gov registration no. NCT02316353). RESULTS: A total of 126 patients with a monthly attack rate of 4.3 in 3 months before entry in COMPACT were enrolled and treated for a mean of 1.5 years; 44 patients (34.9%) had more than 2 years of exposure. Mean steady-state C1-INH functional activity increased to 66.6% with 60 IU/kg. Incidence of adverse events was low and similar in both dose groups (11.3 and 8.5 events per patient-year for 40 IU/kg and 60 IU/kg, respectively). For 40 IU/kg and 60 IU/kg, median annualized attack rates were 1.3 and 1.0, respectively, and median rescue medication use was 0.2 and 0.0 times per year, respectively. Of 23 patients receiving 60 IU/kg for more than 2 years, 19 (83%) were attack-free during months 25 to 30 of treatment. CONCLUSIONS: In patients with frequent HAE attacks, long-term replacement therapy with C1-INH(SC) is safe and exhibits a substantial and sustained prophylactic effect, with the vast majority of patients becoming free from debilitating disease symptoms. (C) 2019 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology.
- Published
- 2019
5. Atopic dermatitis in adults: An Australian management consensus
- Author
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Smith, S, Baker, C, Gebauer, K, Rubel, D, Frankum, B, Soyer, HP, Weightman, W, Sladden, M, Rawlin, M, Headley, AP, Somerville, C, Beuth, J, Logan, N, Mewton, E, Foley, P, Smith, S, Baker, C, Gebauer, K, Rubel, D, Frankum, B, Soyer, HP, Weightman, W, Sladden, M, Rawlin, M, Headley, AP, Somerville, C, Beuth, J, Logan, N, Mewton, E, and Foley, P
- Abstract
BACKGROUND/OBJECTIVES: Atopic dermatitis (AD) has significant negative impact on health-related quality of life, mood, sleep, work productivity and everyday activities. Research into the use of new drugs in the management of AD continues to develop, and international updates and recommendations have been published. However, questions remain in the Australian setting. This consensus aims to provide evidence-based insights and practical advice on the management of adult AD in Australia. METHODS: A panel (five dermatologists and one clinical immunologist) met to review the literature, critically examine clinical questions of relevance to Australian healthcare practitioners and develop a series of recommendation statements. A consensus panel, comprising the initial panel plus nine additional members, used a 2-round Delphi voting process to determine a set of final guidance statements. CONSENSUS: ≥75% agreement in the range 7-9. RESULTS: Round 1 voting comprised 66 guidance statements. Of these, consensus was reached on 26, which were retained, and five were removed. The remainder (35) were modified and one new guidance statement was added for inclusion in round 2 voting. After round 2, consensus was reached on 35, which were retained, and one was removed (considered redundant). The 61 guidance statements upon which consensus was reached were then used to support a series of core consensus recommendations and a management flow chart. CONCLUSIONS: Expert consensus recommendations providing practical guidance of clinical relevance to specialists and primary care physicians in Australia have been developed. Dissemination of this guidance and evaluation of its impact on patient outcomes remain to be undertaken.
- Published
- 2019
6. Hepatitis C infection and Henoch-Schonlein Purpura
- Author
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FRANKUM, B., primary and KATELARIS, C. H., additional
- Published
- 1995
- Full Text
- View/download PDF
7. Management of hay fever
- Author
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Frankum, Brad
- Published
- 1998
8. Tocilizumab for severe COVID-19 pneumonia: Case series of 5 Australian patients.
- Author
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West TA, Malik S, Nalpantidis A, Tran T, Cannon C, Bhonagiri D, Chan K, Cheong E, Wan Sai Cheong J, Cheung W, Choudhury F, Ernest D, Farah CS, Fernando S, Kanapathipillai R, Kol M, Murfin B, Naqvi H, Shah A, Wagh A, Ojaimi S, Frankum B, Riminton S, and Keat K
- Subjects
- Aged, Anti-Inflammatory Agents adverse effects, Antibodies, Monoclonal, Humanized adverse effects, Betacoronavirus pathogenicity, COVID-19, Coronavirus Infections diagnosis, Coronavirus Infections virology, Host Microbial Interactions, Humans, Male, Middle Aged, New South Wales, Pandemics, Pneumonia, Viral diagnosis, Pneumonia, Viral virology, Retrospective Studies, SARS-CoV-2, Severity of Illness Index, Time Factors, Treatment Outcome, Victoria, COVID-19 Drug Treatment, Anti-Inflammatory Agents therapeutic use, Antibodies, Monoclonal, Humanized therapeutic use, Betacoronavirus drug effects, Coronavirus Infections drug therapy, Pneumonia, Viral drug therapy
- Abstract
Aim: To describe the first Australian cases of severe acute respiratory syndrome-coronavirus 2 (SARS-CoV2) disease (COVID-19) pneumonia treated with the interleukin-6 receptor antagonist tocilizumab., Methods: Retrospective, open-label, real-world, uncontrolled, single-arm case series conducted in 2 tertiary hospitals in NSW, Australia and 1 tertiary hospital in Victoria, Australia. Five adult male patients aged between 46 and 74 years with type 1 respiratory failure due to COVID-19 pneumonia requiring intensive care unit (ICU) admission and biochemical evidence of systemic hyperinflammation (C-reactive protein greater than 100 mg/L; ferritin greater than 700 μg/L) were administered variable-dose tocilizumab., Results: At between 13 and 26 days follow-up, all patients are alive and have been discharged from ICU. Two patients have been discharged home. Two patients avoided endotracheal intubation. Oxygen therapy has been ceased in three patients. Four adverse events potentially associated with tocilizumab therapy occurred in three patients: ventilator-associated pneumonia, bacteremia associated with central venous catheterization, myositis and hepatitis. All patients received broad-spectrum antibiotics, 4 received corticosteroids and 2 received both lopinavir/ritonavir and hydroxychloroquine. The time from first tocilizumab administration to improvement in ventilation, defined as a 25% reduction in fraction of inspired oxygen required to maintain peripheral oxygen saturation greater than 92%, ranged from 7 hours to 4.6 days., Conclusions: Tocilizumab use was associated with favorable clinical outcome in our patients. We recommend tocilizumab be included in randomized controlled trials of treatment for patients with severe COVID-19 pneumonia, and be considered for compassionate use in such patients pending the results of these trials., (© 2020 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd.)
- Published
- 2020
- Full Text
- View/download PDF
9. Atopic dermatitis in adults: An Australian management consensus.
- Author
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Smith S, Baker C, Gebauer K, Rubel D, Frankum B, Soyer HP, Weightman W, Sladden M, Rawlin M, Headley AP, Somerville C, Beuth J, Logan N, Mewton E, and Foley P
- Subjects
- Adult, Age Factors, Australia, Consensus, Delphi Technique, Humans, Practice Patterns, Physicians', Quality of Life, Dermatitis, Atopic therapy
- Abstract
Background/objectives: Atopic dermatitis (AD) has significant negative impact on health-related quality of life, mood, sleep, work productivity and everyday activities. Research into the use of new drugs in the management of AD continues to develop, and international updates and recommendations have been published. However, questions remain in the Australian setting. This consensus aims to provide evidence-based insights and practical advice on the management of adult AD in Australia., Methods: A panel (five dermatologists and one clinical immunologist) met to review the literature, critically examine clinical questions of relevance to Australian healthcare practitioners and develop a series of recommendation statements. A consensus panel, comprising the initial panel plus nine additional members, used a 2-round Delphi voting process to determine a set of final guidance statements., Consensus: ≥75% agreement in the range 7-9., Results: Round 1 voting comprised 66 guidance statements. Of these, consensus was reached on 26, which were retained, and five were removed. The remainder (35) were modified and one new guidance statement was added for inclusion in round 2 voting. After round 2, consensus was reached on 35, which were retained, and one was removed (considered redundant). The 61 guidance statements upon which consensus was reached were then used to support a series of core consensus recommendations and a management flow chart., Conclusions: Expert consensus recommendations providing practical guidance of clinical relevance to specialists and primary care physicians in Australia have been developed. Dissemination of this guidance and evaluation of its impact on patient outcomes remain to be undertaken., (© 2019 The Australasian College of Dermatologists.)
- Published
- 2020
- Full Text
- View/download PDF
10. Food avoidance and restriction in adults: a cross-sectional pilot study comparing patients from an immunology clinic to a general practice.
- Author
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Fitzgerald M and Frankum B
- Abstract
Background: With the introduction of avoidant/restrictive food intake disorder (ARFID) in the Diagnostic and Statistical Manual - fifth edition, there is an increased need to understand the prevalence and pattern of food avoidance and restriction in adults. High rates of food allergy and intolerance in immunology clinic populations, and subsequent high rates of elimination diets, place these individuals at a greater risk of developing pathological eating behaviours. This descriptive cross sectional pilot study aims to provide preliminary data on the prevalence and nature of food avoidance and restriction in an adult population, and to explore the reasons for this behaviour., Method: A self-administered questionnaire was designed and distributed to adults presenting to an immunology clinic and a general practice over the course of 6 months to describe the prevalence and nature of avoidant and restrictive eating behaviours in this population. Pearson's chi square test was used to examine the strength of a potential link to a formal diagnosis of avoidant restrictive food intake disorder in these patients., Results: A total of 102 completed questionnaires were used for data analysis. Food avoidance or restriction was detected in 81 respondents (79%), with rates not significantly higher in the immunology clinic group compared to the general practice group ( p = .242). Food allergy and intolerance were the most common reasons for disturbed eating patterns. Life impact secondary to food avoidance and restriction was reported by 26% of respondents, with significantly higher rates observed in the immunology clinic cohort compared to the general practice ( p = .011)., Conclusions: Eating disturbances similar to those characteristic of ARFID are very common in adults. Food avoidance and restriction due to perceived food allergy and intolerance are significant reasons for such disordered eating patterns, particularly in an immunology clinic population. Further investigation is needed to determine if such eating behaviours are pathological and whether they qualify for a diagnosis of ARFID.
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- 2017
- Full Text
- View/download PDF
11. Salicylate elimination diets in children: is food restriction supported by the evidence?
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Gray PE, Mehr S, Katelaris CH, Wainstein BK, Star A, Campbell D, Joshi P, Wong M, Frankum B, Keat K, Dunne G, Dennison B, Kakakios A, and Ziegler JB
- Subjects
- Attention Deficit Disorder with Hyperactivity diet therapy, Child, Child Behavior Disorders diet therapy, Diet adverse effects, Eczema diet therapy, Humans, Treatment Outcome, Diet methods, Salicylates adverse effects
- Abstract
A review of case notes from our Sydney-based paediatric allergy services, between 1 January 2003 and 31 December 2011, identified 74 children who had been prescribed diets that eliminated foods containing natural salicylates before attending our clinics. The most common indications for starting the diets were eczema (34/74) and behavioural disturbances (17/74) including attention deficit hyperactivity disorder (ADHD). We could find no peer-reviewed evidence to support the efficacy of salicylate elimination diets in managing these diseases. We do not prescribe these diets, and in a survey of European and North American food allergy experts, only 1/23 respondents used a similar diet for eczema, with none of the respondents using salicylate elimination to treat ADHD. A high proportion (31/66) of children suffered adverse outcomes, including nutritional deficiencies and food aversion, with four children developing eating disorders. We could find no published evidence to support the safety of these diets in children. While this uncontrolled study does not prove a causal relationship between salicylate elimination diets and harm, the frequency of adverse events appears high, and in the absence of evidence of safety or efficacy, we cannot recommend the use of these diets in children.
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- 2013
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- View/download PDF
12. Adrenaline (epinephrine) autoinjector use in preschools.
- Author
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Joshi P, Katelaris CH, and Frankum B
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- Australia, Child, Child Day Care Centers, Child, Preschool, Health Education statistics & numerical data, Humans, Injections, Intradermal instrumentation, Injections, Intradermal statistics & numerical data, Adrenergic Agonists administration & dosage, Anaphylaxis drug therapy, Epinephrine administration & dosage, Health Personnel education
- Published
- 2009
- Full Text
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13. Chronic human herpes virus 8 infection successfully treated with valganciclovir.
- Author
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Yun JJ, Preda V, and Frankum B
- Abstract
Background: : A 57 year old Italian female with a 3 year history of constituitional symptoms with non-HIV Kaposi sarcoma was referred to the immunology clinic. She was previously diagnosed with chronic human herpes virus 8 (HHV8) infection with positive HHV8 polymerase chain reaction in serum., Objective: : Is valganciclovir effective in treating chronic human herpes virus 8 infection without Multicentric Castleman's Disease (MCD)?, Results: : She was started on valganciclovir, resulting in remission of her symptoms, improvement in inflammatory markers and clearing of detectable HHV8 viraemia, Conclusion: : Valganciclovir is effective in treating symptomatic HHV8 infections without MCD.
- Published
- 2009
- Full Text
- View/download PDF
14. Reforming New South Wales public hospitals: an assessment of the Garling inquiry.
- Author
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Skinner CA, Braithwaite J, Frankum B, Kerridge RK, and Goulston KJ
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- Humans, Interprofessional Relations, Medical Audit, New South Wales, Organizational Culture, Physician's Role, Health Care Reform, Hospital Administration, Hospitals, Public organization & administration, Quality of Health Care organization & administration
- Abstract
The final report of the Special Commission of Inquiry into Acute Care Services in NSW Public Hospitals was published on 27 November 2008. The report acknowledges the challenges facing the New South Wales health system, including increasing numbers of patients, rising treatment costs, workforce pressures, and the breakdown of working relations between clinicians and management. Many of Commissioner Garling's 139 recommendations formalise aspects of clinical care that should and could be happening now if the system were better managed, including better supervision and training of junior staff. Commissioner Garling recommends that change should be driven by clinicians "from the bottom up", but does not adequately describe how this should happen. Implementation of the report's recommendations that will require strong leadership and continuing consultation with clinicians and the community.
- Published
- 2009
- Full Text
- View/download PDF
15. Be very afraid.
- Author
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Frankum B, Attree D, Gatenby A, Eagar S, and Aouad A
- Subjects
- Australia, Humans, New South Wales, Risk Management organization & administration, Fear, Hospital Administration standards, Mass Media, Medical Staff, Hospital organization & administration, Public Relations, Quality Assurance, Health Care organization & administration
- Published
- 2004
16. Vulvitis attributed to hypersensitivity to estrogen. A report of 11 cases.
- Author
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Fischer G, Ayer B, Frankum B, and Spurrett B
- Subjects
- Adolescent, Adult, Child, Diagnosis, Differential, Female, Humans, Middle Aged, Patch Tests, Progesterone adverse effects, Drug Hypersensitivity diagnosis, Estrogens adverse effects, Hormone Replacement Therapy adverse effects, Vulvitis chemically induced
- Abstract
Background: Vulvitis that is refractory to all treatment remains a therapeutic challenge. Hypersensitivity to progesterone and estrogen has been recognized as a rare cause of premenstrual dermatoses. Such hypersensitivity seemed to be the cause of vulvitis in the patients described below., Cases: Nine women had treatment-resistant cyclic vulvitis and two patients had vulvitis develop after commencing hormone replacement therapy (HRT). These patients demonstrated delayed-type hypersensitivity responses by intradermal testing to endogenous estrogens, with two of the patients also reacting to intradermal testing with progesterone. A group of 19 healthy control subjects with no history of vulvar symptoms did not react to any test substance. Ten subjects with other vulvar dermatoses also did not react to any test substance. Of the nine patients with cyclic vulvitis, one recovered at menopause, and three responded to therapy aimed at lowering endogenous estrogen levels. One was able to control symptoms with a potent topical corticosteroid, and four elected not to be treated. Both patients with HRT-related vulvitis recovered when HRT was ceased., Conclusion: Hypersensitivity to estrogen appears to be implicated in chronic, cyclic vulvitis and vulvitis related to HRT in these patients. This is the first report of vulvitis due to estrogen hypersensitivity. The problem may not be rare and should be considered in patients with unexplained cyclic vulvitis unresponsive to standard therapy or in those developing noncandidal vulvitis on HRT. Specific therapy aimed at suppressing or antagonizing estrogen may be required in these patients.
- Published
- 2000
17. Late diagnosis of three cases of transfusion-acquired HIV-1 infection.
- Author
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Learmont JC, Raynes-Greenow CH, Branley JM, Frankum BS, Maddocks S, and Iredell JR
- Subjects
- Adult, Aged, Female, Humans, Male, Middle Aged, HIV Infections diagnosis, HIV Infections etiology, HIV-1, Transfusion Reaction
- Published
- 2000
- Full Text
- View/download PDF
18. Are adverse food reactions linked to irritable bowel syndrome?
- Author
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Niec AM, Frankum B, and Talley NJ
- Subjects
- Clinical Trials as Topic, Double-Blind Method, Humans, Research Design, Colonic Diseases, Functional etiology, Food adverse effects, Food Hypersensitivity complications
- Abstract
Objective: We undertook to determine whether adverse food reactions play a role in irritable bowel syndrome (IBS)., Methods: A systematic review of the literature using Medline (1980-1996), targeting IBS and adverse food reactions, was performed. All clinical trials whereby dietary exclusion was followed by food challenge were selected. Each study was reviewed using a structured format to examine methodological issues and study outcomes., Results: Of the seven studies included, the positive response to an elimination diet ranged from 15% to 71%; double-blind placebo-controlled challenges identified problem foods in 6% to 58% of cases. Milk, wheat, and eggs were most frequently identified to cause symptom exacerbation; of the foods identified the most common trait was a high salicylate content. Foods high in amines were also identified. Studies of diarrhea-predominant IBS identified a higher percentage of adverse food reactions. However, all studies had major limitations in their trial designs, including inadequate patient selection, appropriateness of--and duration of--exclusion diets, and methods of food challenge., Conclusion: Whether adverse reactions to foods are a key factor in exacerbating IBS symptoms or whether dietary manipulation is a valid treatment option is unclear. Carefully designed controlled clinical trials are now needed to specifically test the potential role of adverse food reactions in diarrhea-predominant IBS.
- Published
- 1998
- Full Text
- View/download PDF
19. Managing HIV. Part 5: Treating secondary outcomes. 5.10 HIV and renal disease.
- Author
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Frankum BS and Savdie E
- Subjects
- AIDS-Related Opportunistic Infections complications, Glomerulonephritis diagnosis, Glomerulonephritis etiology, Humans, Kidney Diseases chemically induced, Kidney Diseases diagnosis, Kidney Diseases etiology, Kidney Neoplasms diagnosis, Kidney Neoplasms etiology, Lymphoma, AIDS-Related diagnosis, Nephrocalcinosis diagnosis, Nephrocalcinosis etiology, Prognosis, Renal Dialysis, Sarcoma, Kaposi diagnosis, Sarcoma, Kaposi etiology, Water-Electrolyte Imbalance diagnosis, Water-Electrolyte Imbalance therapy, AIDS-Associated Nephropathy diagnosis, AIDS-Associated Nephropathy therapy
- Abstract
Renal parenchymal and fluid and electrolyte abnormalities may complicate hospitalisation in 20% of patients. HIV-specific renal abnormalities are being defined, but most follow opportunistic infection or drug nephrotoxicity. Principles of treatment are largely the same as for patients without HIV.
- Published
- 1996
20. Ozone therapy in AIDS--truly innocuous?
- Author
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Frankum B and Katelaris CH
- Subjects
- Adult, Humans, Male, Acquired Immunodeficiency Syndrome therapy, Ozone adverse effects, Ozone therapeutic use, Pancytopenia chemically induced
- Published
- 1993
- Full Text
- View/download PDF
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