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178 results on '"Frankenberg-Schwager M"'

31. Transformation of C3H 10T1/2 cells by low doses of ionising radiation: a collaborative study by six European laboratories strongly supporting a linear dose-response relationship

Author

Mill, A J, primary, Frankenberg, D, additional, Bettega, D, additional, Hieber, L, additional, Saran, A, additional, Allen, L A, additional, Calzolari, P, additional, Frankenberg-Schwager, M, additional, Lehane, M M, additional, Morgan, G R, additional, Pariset, L, additional, Pazzaglia, S, additional, Roberts, C J, additional, and Tallone, L, additional

Published
1998
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40. The RBE of 3.4 MeV α-particles and 0.565 MeV neutrons relative to 60Co γ-rays for neoplastic transformation of human hybrid cells and the impact of culture conditions.

Author

Frankenberg-Schwager, M., Spieren, S., Pralle, E., Giesen, U., Brede, H. J., Thiemig, M., and Frankenberg, D.

Subjects
RADIATION doses, MEDICAL radiology, NEUTRONS, MULTIPLE endocrine neoplasia, CELL culture
Abstract

The neoplastic transformation of human hybrid CGL1 cells is affected by perturbations from external influences such as serum batch and concentration, the number of medium changes during the 21-day expression period and cell seeding density. Nevertheless, for doses up to 1.5 Gy, published transformation frequencies for low linear energy transfer (LET) radiations (γ-rays, MeV electrons or photons) are in good agreement, whereas for higher doses larger variations are reported. The 60Co γ-ray data here for doses up to 1.5 Gy, using a low-yield serum batch and only one medium change, are in agreement with published frequencies of neoplastic transformation of human hybrid cells. For 3.4 MeV α-particles (LET = 124 keV/μm) and 0.565 MeV monoenergetic neutrons relative to low doses of 60Co γ-rays, a maximum relative biological effectiveness (RBEM) of 2.8 ± 0.2 and 1.5 ± 0.2, respectively, was calculated. Surprisingly, at higher doses of 60Co γ-rays lower frequencies of neoplastic transformation were observed. This non-monotonic dose relationship for neoplastic transformation by 60Co γ-rays is likely due to the lack of a G2/M arrest observed at low doses resulting in higher transformation frequencies per dose, whereas the lower frequencies per dose observed for higher doses are likely related to the induction of a G2/M arrest. [ABSTRACT FROM PUBLISHER]

Published
2010
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50. Effectiveness of 1·5 keV Aluminium K and 0·3 keV Carbon K Characteristic X-rays at Inducing DNA Double-strand Breaks in Yeast Cells

Author

Frankenberg, D., Goodhead, D.T., Frankenberg-Schwager, M., Harbich, R., Bance, D.A., and Wilkinson, R.E.

Abstract

Induction of DNA double-strand breaks in diploid wild-type yeast cells, and inactivation of diploid mutant cells (rad54-3) unable to repair DNA double-strand breaks, were studied with aluminium K (1·5 keV) and carbon K (0·278 keV) characteristic X-rays. The induction of DNA double-strand breaks was found to increase linearly with absorbed dose for both characteristic X-rays. Carbon K X-rays were more effective than aluminium K X-rays. Relative to 60Co γ-rays the r.b.e-values for the induction of DNA double-strand breaks were found to be 3·8 and 2·2 for carbon K and aluminium K X-rays respectively. The survival curves of the rad54-3 mutant cells were exponential for both ultrasoft X-rays. For inactivation of rad54-3 mutant cells, the r.b.e.-values relative to 60Co γ-rays were 2·6 and 2·4 for carbon K and aluminium K X-rays, respectively. The DNA double-strand break data obtained with aluminium K and carbon K X-rays are in agreement with the data obtained for gene mutation, chromosome aberrations and inactivation of mammalian cells, suggesting that DNA double-strand breaks are the possible molecular lesions leading to these effects

Published
1986
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