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An 83-year-old female had asymptomatic SARS-CoV-2 infection while taking ruxolitinib. She remained RT-PCR positive for viral RNA for >120 days, and Pegylated interferon for 4 weeks led to viral RNA clearance. The observations support combination therapy of ruxolitinib + interferon for COVID-19.

The US Geological Survey National Seismic Hazard Models (NSHMs) are used to calculate earthquake ground-shaking intensities for design and rehabilitation of structures in the United States. The most recent 2014 and 2018 versions of the NSHM for the conterminous United States included major updates to ground-motion models (GMMs) for active and stable crustal tectonic settings; however, the subduction zone GMMs were largely unchanged. With the recent development of the next generation attenuation-subduction (NGA-Sub) GMMs, and recent progress in the utilization of "M9" Cascadia earthquake simulations, we now have access to improved models of ground shaking in the US subduction zones and the Seattle basin. The new NGA-Sub GMMs support multi-period response spectra calculations. They provide global models and regional terms specific to Cascadia and terms that account for deep-basin effects. This article focuses on the updates to subduction GMMs for implementation in the 2023 NSHM and compares them to the GMMs of previous NSHMs. Individual subduction GMMs, their weighted averages, and their impact on the estimated mean hazard relative to the 2018 NSHM are discussed. The updated logic trees include three of the new NGA-Sub GMMs and retain two older models to represent epistemic uncertainty in both the median and standard deviation of ground-shaking intensities at all periods of interest. Epistemic uncertainty is further represented by a three-point logic tree for the NGA-Sub median models. Finally, in the Seattle region, basin amplification factors are adjusted at long periods based on the state-of-the-art M9 Cascadia earthquake simulations. The new models increase the estimated mean hazard values at short periods and short source-to-site distances for interface earthquakes, but decrease them otherwise, relative to the 2018 NSHM. On softer soils, the new models cause decreases to the estimated mean hazard for long periods in the Puget Lowlands basin but increases within the deep Seattle portion of this basin for short periods relative to the 2018 NSHM. [ABSTRACT FROM AUTHOR]

The US National Seismic Hazard Model (NSHM) was updated in 2023 for all 50 states using new science on seismicity, fault ruptures, ground motions, and probabilistic techniques to produce a standard of practice for public policy and other engineering applications (defined for return periods greater than ∼475 or less than ∼10,000 years). Changes in 2023 time-independent seismic hazard (both increases and decreases compared to previous NSHMs) are substantial because the new model considers more data and updated earthquake rupture forecasts and ground-motion components. In developing the 2023 model, we tried to apply best available or applicable science based on advice of co-authors, more than 50 reviewers, and hundreds of hazard scientists and end-users, who attended public workshops and provided technical inputs. The hazard assessment incorporates new catalogs, declustering algorithms, gridded seismicity models, magnitude-scaling equations, fault-based structural and deformation models, multi-fault earthquake rupture forecast models, semi-empirical and simulation-based ground-motion models, and site amplification models conditioned on shear-wave velocities of the upper 30 m of soil and deeper sedimentary basin structures. Seismic hazard calculations yield hazard curves at hundreds of thousands of sites, ground-motion maps, uniform-hazard response spectra, and disaggregations developed for pseudo-spectral accelerations at 21 oscillator periods and two peak parameters, Modified Mercalli Intensity, and 8 site classes required by building codes and other public policy applications. Tests show the new model is consistent with past ShakeMap intensity observations. Sensitivity and uncertainty assessments ensure resulting ground motions are compatible with known hazard information and highlight the range and causes of variability in ground motions. We produce several impact products including building seismic design criteria, intensity maps, planning scenarios, and engineering risk assessments showing the potential physical and social impacts. These applications provide a basis for assessing, planning, and mitigating the effects of future earthquakes. [ABSTRACT FROM AUTHOR]

We simulate shaking in Tacoma, Washington, and surrounding areas from MW 6.5 and 7.0 earthquakes on the Tacoma fault. Ground motions are directly modeled up to 2.5 Hz using kinematic, finite-fault sources; a 3D seismic velocity model considering regional geology; and a model mesh with 30 m sampling at the ground surface. In addition, we explore how adjustments to the seismic velocity model affect predicted shaking over a range of periods. These adjustments include the addition of a region-specific geotechnical gradient, surface topography, and a fault damage zone. We find that the simulated shaking tends to be near estimates from empirical ground-motion models (GMMs). However, long-period (T = 5.0 s) shaking within the Tacoma basin is typically underpredicted by the GMMs. The fit between simulated and GMM-derived short-period (T = 0.5 s) shaking is significantly improved with the addition of the geotechnical gradient. From comparing different MW 6.5 earthquake scenarios, we also find that the response of the Tacoma basin is sensitive to the azimuth of incoming seismic waves. In adding surface topography to the simulation, we find that average ground motion is similar to that produced from the nontopography model. However, shaking is often amplified at topographic highs and deamplified at topographic lows, and the wavefield undergoes extensive scattering. Adding a fault damage zone has the effect of amplifying short-period shaking adjacent to the fault, while reducing far-field shaking. Intermediate-period shaking is amplified within the Tacoma basin, likely due to enhanced surface-wave generation attributable to the fault damage zone waveguide. When applied in the same model, the topography and fault damage zone adjustments often enhance or reduce the effects of one another, adding further complexity to the wavefield. These results emphasize the importance of improving near-surface velocity model resolution as waveform simulations progress toward higher frequencies. [ABSTRACT FROM AUTHOR]