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1. Disparities in SARS-CoV-2 Infection by Race, Ethnicity, Language, and Social Vulnerability: Evidence from a Citywide Seroprevalence Study in Massachusetts, USA

Author

Matias, Wilfredo R., Fulcher, Isabel R., Sauer, Sara M., Nolan, Cody P., Guillaume, Yodeline, Zhu, Jack, Molano, Francisco J., Uceta, Elizabeth, Collins, Shannon, Slater, Damien M., Sánchez, Vanessa M., Moheed, Serina, Harris, Jason B., Charles, Richelle C., Paxton, Ryan M., Gonsalves, Sean F., Franke, Molly F., and Ivers, Louise C.

Published
2024
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2. Impact and cost-effectiveness of the 6-month BPaLM regimen for rifampicin-resistant tuberculosis in Moldova: A mathematical modeling analysis

Author

James, Lyndon P., Klaassen, Fayette, Sweeney, Sedona, Furin, Jennifer, Franke, Molly F., Yaesoubi, Reza, Chesov, Dumitru, Ciobanu, Nelly, Codreanu, Alexandru, Crudu, Valeriu, Cohen, Ted, and Menzies, Nicolas A.

Subjects
Moldova -- Health aspects, Antitubercular agents -- Dosage and administration -- Physiological aspects -- Economic aspects, Pharmacology, Experimental, Drug therapy, Combination -- Physiological aspects -- Economic aspects -- Models, Tuberculosis -- Drug therapy -- Models -- Physiological aspects, Biological sciences
Abstract

Background Emerging evidence suggests that shortened, simplified treatment regimens for rifampicin-resistant tuberculosis (RR-TB) can achieve comparable end-of-treatment (EOT) outcomes to longer regimens. We compared a 6-month regimen containing bedaquiline, pretomanid, linezolid, and moxifloxacin (BPaLM) to a standard of care strategy using a 9- or 18-month regimen depending on whether fluoroquinolone resistance (FQ-R) was detected on drug susceptibility testing (DST). Methods and findings The primary objective was to determine whether 6 months of BPaLM is a cost-effective treatment strategy for RR-TB. We used genomic and demographic data to parameterize a mathematical model estimating long-term health outcomes measured in quality-adjusted life years (QALYs) and lifetime costs in 2022 USD ($) for each treatment strategy for patients 15 years and older diagnosed with pulmonary RR-TB in Moldova, a country with a high burden of TB drug resistance. For each individual, we simulated the natural history of TB and associated treatment outcomes, as well as the process of acquiring resistance to each of 12 anti-TB drugs. Compared to the standard of care, 6 months of BPaLM was cost-effective. This strategy was estimated to reduce lifetime costs by $3,366 (95% UI: [1,465, 5,742] p < 0.001) per individual, with a nonsignificant change in QALYs (-0.06; 95% UI: [-0.49, 0.03] p = 0.790). For those stopping moxifloxacin under the BPaLM regimen, continuing with BPaL plus clofazimine (BPaLC) provided more QALYs at lower cost than continuing with BPaL alone. Strategies based on 6 months of BPaLM had at least a 93% chance of being cost-effective, so long as BPaLC was continued in the event of stopping moxifloxacin. BPaLM for 6 months also reduced the average time spent with TB resistant to amikacin, bedaquiline, clofazimine, cycloserine, moxifloxacin, and pyrazinamide, while it increased the average time spent with TB resistant to delamanid and pretomanid. Sensitivity analyses showed 6 months of BPaLM to be cost-effective across a broad range of values for the relative effectiveness of BPaLM, and the proportion of the cohort with FQ-R. Compared to the standard of care, 6 months of BPaLM would be expected to save Moldova's national TB program budget $7.1 million (95% UI: [1.3 million, 15.4 million] p = 0.002) over the 5-year period from implementation. Our analysis did not account for all possible interactions between specific drugs with regard to treatment outcomes, resistance acquisition, or the consequences of specific types of severe adverse events, nor did we model how the intervention may affect TB transmission dynamics. Conclusions Compared to standard of care, longer regimens, the implementation of the 6-month BPaLM regimen could improve the cost-effectiveness of care for individuals diagnosed with RR-TB, particularly in settings with a high burden of drug-resistant TB. Further research may be warranted to explore the impact and cost-effectiveness of shorter RR-TB regimens across settings with varied drug-resistant TB burdens and national income levels., Author(s): Lyndon P. James 1,2,*, Fayette Klaassen 3, Sedona Sweeney 4, Jennifer Furin 5, Molly F. Franke 5, Reza Yaesoubi 6, Dumitru Chesov 7,8, Nelly Ciobanu 9, Alexandru Codreanu 9, [...]

Published
2024
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4. Seroprevalence of Vibrio cholerae in Adults, Haiti, 2017

Author

Matias, Wilfredo R., Guillaume, Yodeline, Augustin, Gertrude Cene, Vissieres, Kenia, Ternier, Ralph, Charles, Richelle C., Harris, Jason B., Franke, Molly F., and Ivers, Louise C.

Subjects
Cholera toxin -- Health aspects, Medical research -- Health aspects, Medicine, Experimental -- Health aspects, Communicable diseases -- Health aspects, Viral antibodies -- Health aspects, Public health -- Health aspects, Adults -- Health aspects, Antibodies -- Health aspects, Cholera -- Health aspects, Health
Abstract

In 2010, cholera, caused by the bacterium Vibrio cholerae, was introduced into Haiti, resulting in >800,000 cases and >10,000 deaths (1,2). Case incidence peaked in 2012, then decreased, and the [...]

Published
2023
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6. User Perceptions of an mHealth Medicine Dosing Tool for Community Health Workers

Author

Palazuelos, Daniel, Diallo, Assiatou B, Palazuelos, Lindsay, Carlile, Narath, Payne, Jonathan D, and Franke, Molly F

Subjects
Information technology, T58.5-58.64, Public aspects of medicine, RA1-1270
Abstract

BackgroundMobile health (mHealth) technologies provide many potential benefits to the delivery of health care. Medical decision support tools have shown particular promise in improving quality of care and provider workflow. Frontline health workers such as Community Health Workers (CHWs) have been shown to be effective in extending the reach of care, yet only a few medicine dosing tools are available to them. ObjectiveWe developed an mHealth medicine dosing tool tailored to the skill level of CHWs to assist in the delivery of care. The mHealth tool was created for CHWs with primary school education working in rural Mexico and Guatemala. Perceptions and impressions of this tool were collected and compared to an existing paper-based medicine dosing tool. MethodsSeventeen Partners In Health CHWs in rural Mexico and Guatemala completed a one-day training in the mHealth medicine dosing tool. Following the training, a prescription dosing test was administered, and CHWs were given the choice to use the mHealth or paper-based tool to answer 7 questions. Subsequently, demographic and qualitative data was collected using a questionnaire and an in-person interview conducted in Spanish, then translated into English. The qualitative questions captured data on 4 categories: comfort, acceptability, preference, and accuracy. Qualitative responses were analyzed for major themes and quantitative variables were analyzed using SAS. Results82% of the 17 CHWs chose the mHealth tool for at least 1 of 7 questions compared to 53% (9/17) who chose to use the paper-based tool. 93% (13/14) rated the phone as being easy or very easy to use, and 56% (5/9) who used the paper-based tool rated it as easy or very easy. Dosing accuracy was generally higher among questions answered using the mHealth tool relative to questions answered using the paper-based tool. Analysis of major qualitative themes indicated that the mHealth tool was perceived as being quick, easy to use, and as having complete information. The mHealth tool was seen as an acceptable dosing tool to use and as a way for CHWs to gain credibility within the community. ConclusionsA tailored cell phone-based mHealth medicine dosing tool was found to be useful and acceptable by CHWs in rural Mexico and Guatemala. The streamlined workflow of the mHealth tool and benefits such as the speed and self-lighting were found to be particularly useful features. Well designed and positioned tools such as this may improve effective task shifting by reinforcing the tasks that different cadres of workers are asked to perform. Further studies can explore how to best implement this mHealth tool in real-world settings, including how to incorporate the best elements of the paper-based tool that were also found to be helpful.

Published
2013
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10. Low body mass index as a predictor of sputum culture conversion and treatment outcomes among patients receiving treatment for multidrug-resistant tuberculosis in Lesotho

Author

Oyewusi, Lawrence, primary, Zeng, Chengbo, additional, Seung, KJ, additional, Mpinda, Stephanie, additional, Kunda, Mikanda, additional, Mitnick, Carole D, additional, Kanu, Makelele, additional, Tamirat, Meseret, additional, Makaka, Joalane, additional, Mofolo, Mabatloung, additional, Maime, Refiloe, additional, Maama, Llang, additional, Senyo, Ninza, additional, Oguntoyinbo, Bamidele, additional, Mayombo, Lwayi, additional, and Franke, Molly F, additional

Published
2024
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11. Evaluation of the Access Bio CareStart rapid SARS-CoV-2 antigen test in asymptomatic individuals tested at a community mass-testing program in Western Massachusetts

Author

Suliman, Sara, Matias, Wilfredo R., Fulcher, Isabel R., Molano, Francisco J., Collins, Shannon, Uceta, Elizabeth, Zhu, Jack, Paxton, Ryan M., Gonsalves, Sean F., Harden, Maegan V., Fisher, Marissa, Meldrim, Jim, Gabriel, Stacey, Franke, Molly F., Hung, Deborah T., Smole, Sandra C., Madoff, Lawrence C., and Ivers, Louise C.

Published
2022
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12. Effectiveness of a bedaquiline, linezolid, clofazimine "core" for multidrug-resistant tuberculosis

Author

Zeng, Chengbo, primary, Hernan, Miguel A., additional, Trevisi, Letizia, additional, Sauer, Sara, additional, Mitnick, Carole D., additional, Hewison, Catherine, additional, Bastard, Mathieu, additional, Khan, Palwasha, additional, Seung, Kwonjune J., additional, Rich, Michael L., additional, Law, Stephaine, additional, Kikvidze, Marina, additional, Kirakosyan, Ohanna, additional, Miankou, Alexey, additional, Thit, Phone, additional, Mamsa, Shahid, additional, Janmohamed, Aleeza, additional, Melikyan, Nara, additional, Ahmed, Saman, additional, Vargas, Dante, additional, Binegdie, Amsalu Bekele, additional, Temirova, Kulbaram, additional, Oyewusi, Lawrence, additional, Philippe, Kerline, additional, Vilbrun, Stalz C., additional, Khan, Uzma, additional, Huerga, Helena, additional, and Franke, Molly F., additional

Published
2024
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17. Retention and Viral Suppression Among Adolescents Newly Initiating Antiretroviral Therapy in Adult HIV Care in Lima, Peru: A Retrospective Cohort Study

Author

Niwa, Miyu, primary, Matos, Eduardo, additional, Rodriguez, Carly, additional, Wong, Milagros, additional, Errea, Renato A., additional, Ramos, Alicia, additional, Senador, Liz, additional, Contreras, Carmen, additional, Galea, Jerome T., additional, Lindeborg, Andrew, additional, Benites, Carlos, additional, Shin, Sonya S., additional, Lecca, Leonid, additional, and Franke, Molly F., additional

Published
2023
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18. Pregnancy and Birth Outcomes in Patients With Multidrug-Resistant Tuberculosis Treated With Regimens That Include New and Repurposed Drugs

Author

Lotia Farrukh, Ismat, primary, Lachenal, Nathalie, additional, Adenov, Malik M, additional, Ahmed, Saman, additional, Algozhin, Yerkebulan, additional, Coutisson, Sylvine, additional, Garavito, Epifanio Sánchez, additional, Hewison, Catherine, additional, Holtzman, David, additional, Huerga, Helena, additional, Janmohamed, Aleeza, additional, Khan, Palwasha Y, additional, Jacques, Gamarly Leblanc, additional, Lomtadze, Nino, additional, Melikyan, Nara, additional, Mitnick, Carole D, additional, Mussabekova, Gulnaz, additional, Osso, Elna, additional, Perea, Sara, additional, Putri, Fauziah Asnely, additional, Rashidov, Mahmud, additional, Rich, Michael L, additional, Sakhabutdinova, Yekaterina, additional, Seung, Kwonjune J, additional, Stambekova, Assel, additional, Vásquez, Dante Vargas, additional, Franke, Molly F, additional, and Khan, Uzma, additional

Published
2023
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21. Impact and cost-effectiveness of the 6-month BPaLM regimen for rifampicin-resistant tuberculosis: a mathematical modeling analysis

Author

James, Lyndon P, primary, Klaassen, Fayette, additional, Sweeney, Sedona, additional, Furin, Jennifer, additional, Franke, Molly F, additional, Yaesoubi, Reza, additional, Chesov, Dumitru, additional, Ciobanu, Nelly, additional, Codreanu, Alexandru, additional, Crudu, Valeriu, additional, Cohen, Ted, additional, and Menzies, Nicolas A, additional

Published
2023
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23. Respiratory, Cardiac, and Neuropsychiatric Manifestations of Postacute Sequelae of Coronavirus Disease 2019 in Lima, Peru

Author

Rahman, Rifat S, primary, Tovar, Marco A, additional, Peinado, Jesús, additional, Palomino, J Santiago, additional, Ramirez, Claudio, additional, Llanos-Zavalaga, Fernando, additional, Peralta, Ernesto, additional, Valderrama, Gissela, additional, Ramos Cordova, Lourdes B, additional, Sanchez Cortez, Lucero I, additional, Rodriguez, German, additional, LaHood, Allison N, additional, Franke, Molly F, additional, Mitnick, Carole D, additional, Lecca, Leonid, additional, and Velásquez, Gustavo E, additional

Published
2023
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26. Development of treatment-decision algorithms for children evaluated for pulmonary tuberculosis: an individual participant data meta-analysis

Author

Gunasekera, Kenneth S, primary, Marcy, Olivier, additional, Muñoz, Johanna, additional, Lopez-Varela, Elisa, additional, Sekadde, Moorine P, additional, Franke, Molly F, additional, Bonnet, Maryline, additional, Ahmed, Shakil, additional, Amanullah, Farhana, additional, Anwar, Aliya, additional, Augusto, Orvalho, additional, Aurilio, Rafaela Baroni, additional, Banu, Sayera, additional, Batool, Iraj, additional, Brands, Annemieke, additional, Cain, Kevin P, additional, Carratalá-Castro, Lucía, additional, Caws, Maxine, additional, Click, Eleanor S, additional, Cranmer, Lisa M, additional, García-Basteiro, Alberto L, additional, Hesseling, Anneke C, additional, Huynh, Julie, additional, Kabir, Senjuti, additional, Lecca, Leonid, additional, Mandalakas, Anna, additional, Mavhunga, Farai, additional, Myint, Aye Aye, additional, Myo, Kyaw, additional, Nampijja, Dorah, additional, Nicol, Mark P, additional, Orikiriza, Patrick, additional, Palmer, Megan, additional, Sant'Anna, Clemax Couto, additional, Siddiqui, Sara Ahmed, additional, Smith, Jonathan P, additional, Song, Rinn, additional, Thuong Thuong, Nguyen Thuy, additional, Ung, Vibol, additional, van der Zalm, Marieke M, additional, Verkuijl, Sabine, additional, Viney, Kerri, additional, Walters, Elisabetta G, additional, Warren, Joshua L, additional, Zar, Heather J, additional, Marais, Ben J, additional, Graham, Stephen M, additional, Debray, Thomas P A, additional, Cohen, Ted, additional, and Seddon, James A, additional

Published
2023
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34. Effectiveness of Bedaquiline Use Beyond Six Months in Patients with Multidrug-Resistant Tuberculosis

Author

Trevisi, Letizia, primary, Hernán, Miguel A., additional, Mitnick, Carole D, additional, Khan, Uzma, additional, Seung, Kwonjune J, additional, Rich, Michael L., additional, Bastard, Mathieu, additional, Huerga, Helena, additional, Melikyan, Nara, additional, Atwood, Sidney, additional, Avaliani, Zaza, additional, Llanos, Felix, additional, Manzur-ul-Alam, Mohammed, additional, Zarli, Khin, additional, Binedgie, Amsalu Bekele, additional, Adnan, Sana, additional, Melikyan, Arusyak, additional, Gelin, Alain, additional, Isani, Afshan K, additional, Vetushko, Dmitry, additional, Daugarina, Zhenisgul, additional, Nkundanyirazo, Patrick, additional, Putri, Fauziah Asnely, additional, Vilbrun, Charles, additional, Khan, Munira, additional, Hewison, Catherine, additional, Khan, Palwasha Y, additional, and Franke, Molly F, additional

Published
2023
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40. Disparities in SARS-CoV-2 Infection by Race, Ethnicity, Language, and Social Vulnerability: Evidence from a Citywide Seroprevalence Study in Massachusetts, USA

Author

Matias, Wilfredo R., primary, Fulcher, Isabel R., additional, Sauer, Sara M., additional, Nolan, Cody P., additional, Guillaume, Yodeline, additional, Zhu, Jack, additional, Molano, Francisco J., additional, Uceta, Elizabeth, additional, Collins, Shannon, additional, Slater, Damien M., additional, Sánchez, Vanessa M., additional, Moheed, Serina, additional, Harris, Jason B., additional, Charles, Richelle C., additional, Paxton, Ryan M., additional, Gonsalves, Sean F., additional, Franke, Molly F., additional, and Ivers, Louise C., additional

Published
2023
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43. Selection bias in multidrug-resistant tuberculosis cohort studies assessing sputum culture conversion

Author

Rodriguez, Carly A., primary, Lodi, Sara, additional, Horsburgh, C. Robert, additional, Bastard, Mathieu, additional, Hewison, Cathy, additional, Huerga, Helena, additional, Khan, Munira, additional, Khan, Palwasha Y., additional, Khan, Uzma, additional, Oyewusi, Lawrence, additional, Padayachee, Shrivani, additional, Mitnick, Carole D., additional, and Franke, Molly F., additional

Published
2022
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45. Additional file 1 of Low detection rate of RT-PCR-confirmed COVID-19 using IgM/IgG rapid antibody tests in a large community sample in Lima, Peru

Author

Law, Stephanie, Tovar, Marco A., Franke, Molly F., Calderon, Roger, Palomino, Santiago, Valderrama, Gissella, Llanos, Fernando, Velásquez, Gustavo E., Mitnick, Carole D., and Lecca, Leonid

Abstract

Additional file 1. Table S1. Reported symptoms of all participants with sample collected (and tested) for serologic antibody test on same day as sample that resulted in RT-PCR positive for SARS-CoV-2 (n=492); no symptom duration outliers excluded. Table S2. Reported symptoms of all participants with sample collected (and tested) for serologic antibody test on same day as sample that resulted in RT-PCR positive for SARS-CoV-2 (n=492); mild and extreme symptom duration outliers excluded. Table S3. Sensitivity of the rapid antibody test# by symptom duration and outlier exclusion criteria. Fig. S1. Plots of antibody test sensitivity against the number of weeks since onset of symptoms among those who reported at least one symptom before testing, using the RT-PCR test as the reference, stratified by the types of outliers excluded in the analysis: extreme outliers, which were defined as persons whose time since symptom onset was longer than the third quartile plus 3 times the interquartile range (IQR, defined as the difference between the first and third quartile of the reported times since onset for a given symptom); mild outliers were those beyond the third quartile plus 1.5 times the IQR); or no outliers excluded. The circles show the crude estimated sensitivity and the error bars show the Wilson’s score 95% confidence intervals. The plotted lines are the fitted segmented linear regressions for the rapid antibody tests. Table S4. Segmented regression analyses of antibody test sensitivity by weeks since symptom onset, by symptom duration outlier exclusion criteria. Table S5. Overall antibody test sensitivity* per week since symptom onset for common symptoms. Table S6.Segmented regression analyses of antibody test sensitivity versus weeks since symptom onset, by symptom.

Published
2023
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