1. Younger age is associated with greater early neurocognitive decline postcardiopulmonary bypassCentral MessagePerspective
- Author
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Kelsey Anderson, BA, Olivia Ziegler, BA, Guangbin Shi, MD, MSc, Neel Sodha, MD, Ian Ikeda, BS, Jun Feng, MD, PhD, and Frank Sellke, MD
- Subjects
neurocognitive decline ,cardiothoracic surgery ,age ,inflammation ,CPB ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 ,Surgery ,RD1-811 - Abstract
Objective: To examine the effect of aging on postoperative neurocognitive decline (NCD) in cardiac surgery patients. Methods: Patients undergoing coronary artery bypass graft or open aortic valve replacement were administered the Repeatable Battery for the Assessment of Neuropsychological Status at preoperative, postoperative day (POD) 4, and 1 month. Blood samples were collected at preoperative, 6 hours postoperative, and POD 4. Plasma interleukin (IL)-6, tumor necrosis factor-α, and C-reactive protein (CRP) levels were quantified. Quality of life was measured with the 12-Item Short Form Health Survey. Data were analyzed using paired ratio and unpaired t tests with Welch's correction, and linear regression for cytokine levels. Results: NCD occurred in 15 patients (N = 33, 45.5%). Dichotomized at age extremes (
- Published
- 2020
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