1. A Community-Based Pancreatic Cancer Screening Study in High-Risk Individuals: Preliminary Efficacy and Safety Results
- Author
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Kandiah, Jonathan, Lo, Tammy, Jin, Dugho, Melchior, Landon, Krebs, Thorsten L, Anand, Naveen, Ingram, Susan, Krumholtz, Pramila, Pandya, Deep, Trinidad, Antolin, Dong, Xiang, Seshadri, Ramanathan, Bauman, James, Lee, Ronald, and Frank, Richard C
- Subjects
Mental Health ,Clinical Research ,Cancer ,Biomedical Imaging ,Digestive Diseases ,Pancreatic Cancer ,Clinical Trials and Supportive Activities ,Rare Diseases ,Depression ,Biological Specimen Banks ,Early Detection of Cancer ,Humans ,Pancreatic Neoplasms ,Prospective Studies ,Clinical Sciences - Abstract
IntroductionPancreatic cancer (PC) screening recommendations have been based on studies performed solely at high-volume academic centers. To make PC screening more widely available, community-based efforts are essential. We implemented a prospective PC screening study in the community of Fairfield County, CT, and report our early safety and efficacy results.MethodsEligible individuals were enrolled into an investigator-initiated study and underwent a baseline and 3 annual magnetic resonance imagings/magnetic resonance cholangiopancreatographies (MRIs/MRCPs) with gadolinium, biannual blood donations for biobanking, and assessments for anxiety and depression. All MRIs were presented at a multidisciplinary board to determine whether further investigation was warranted.ResultsSeventy-five individuals have been enrolled and 201 MRIs performed over a 2.6-year average length of follow-up. Abnormal pancreatic findings (predominantly small cysts) were detected in 58.7% of the participants. Among these, 6.7% underwent endoscopic ultrasound, with 1 case complicated by postprocedural pancreatitis. One surgical resection was performed on a 4.7-cm intraductal papillary mucinous neoplasm with a focus on low-grade pancreatic intraepithelial neoplasia. One incidental finding of fibrosing mediastinitis was detected. Anxiety and depression scores decreased over the course of this study from 21.4% to 5.4% and 10.7% to 3.6%, respectively.DiscussionThis preliminary report supports the feasibility of performing MRI/magnetic resonance cholangiopancreatographies-based PC screening as part of a clinical trial in a community setting. A longer follow-up is needed to better assess safety and efficacy. To the best of our knowledge, this is the first report from a community-based PC screening effort ( clinicaltrials.gov ID: NCT03250078).
- Published
- 2022