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Your search keyword '"Francois-Noël Gilly"' showing total 3 results
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3 results on '"Francois-Noël Gilly"'

1. Dictionnaire des îles : France (métropole et Outre-mer)

Author

Francois-Noël Gilly and Francois-Noël Gilly

Abstract

Les îles sont multiples : ensoleillées et bordées de sable blanc ou cernées de falaises indomptables, isolées au milieu d'un océan ou tendant leur bras vers une côte toute proche, désertes ou habitées d'êtres que l'on nomme « iliens »… toutes sont envoûtantes, attirantes, chargées de mystères, incarnant une illusion de liberté ou des rêves d'enfant. La France a le privilège de posséder des îles le long de ses côtes et sur les quatre grands océans de la planète : quatre-vingt-quinze pour cent d'entre elles sont ignorées des Français. La Gaule était « terrienne », les Rois de France prêtaient plus d'attention au sol national qu'aux mers et aux océans. Les Républiques ont maintenu cette vision et pourraient aujourd'hui encore prendre pour elles la phrase du cardinal de Richelieu : « les larmes de nos souverains ont le goût salé de la mer qu'ils ont négligée ». Toutes ces îles, très proches ou très lointaines, célèbres ou inconnues, sont réunies dans ce Dictionnaire.

Published
2025

2. Survival after gamma interferon intratumoral injections in a model of hepatocarcinoma

Author

Vincent, Peyrègne, Gerard, Quash, Sylvie, Isaac, Jacqueline, Chantepie, Hitoshi, Akiba, Jean-Yves, Scoazec, and Francois-Noël, Gilly

Subjects
Cell Nucleus, Carcinoma, Hepatocellular, Neutrophils, Liver Neoplasms, Histocompatibility Antigens Class II, Mice, Nude, Antineoplastic Agents, Injections, Intralesional, Survival Analysis, Antibodies, Cell Line, Disease Models, Animal, Interferon-gamma, Mice, Necrosis, Animals, Humans, Cell Division
Abstract

Short-term efficacy of local gamma interferon delivered via a single injection of an adenovirus-gamma interferon vector has been reported in immunocompetent animals which develop spontaneous liver cancer. However the long-term outcome was not examined. The aim of this randomized trial was to assess in an immunodeficient mouse ectopic model the benefit, if any, of the long-term efficacy of intratumoral injections of gamma interferon itself.77 mice were randomly assigned to 4 groups. Gamma interferon treated groups received a dose of 5000, 10000 or 20000 IU per animal versus phosphate-buffered saline. The follow-up lasted 46 days.Significant differences were noted in mice receiving 20000 IU compared to controls: increase in survival (p=0.0485), slowing down of tumor growth in large tumors (p=0.009), increase in necrosis (p=0.004). The preferential staining in necrotic areas with anti-Class II antibody and the accumulation of nuclear debris indicated that neutrophils were involved.Gamma interferon could accentuate the migration of non-specific immune cells to necrotic areas which occur spontaneously in large tumors. These results in animals bearing large tumor suggest that it may be worthwhile to explore local gamma interferon delivery to patients with extensive hepatocarcinoma.

Published
2004

3. Survival impact of centralization and clinical guidelines for soft tissue sarcoma (A prospective and exhaustive population-based cohort).

Author

Olfa Derbel, Pierre Etienne Heudel, Claire Cropet, Pierre Meeus, Gualter Vaz, Pierre Biron, Philippe Cassier, Anne-Valérie Decouvelaere, Dominique Ranchere-Vince, Olivier Collard, Eric De Laroche, Philippe Thiesse, Fadila Farsi, Dominic Cellier, François-Noel Gilly, Jean-Yves Blay, and Isabelle Ray-Coquard

Subjects
Medicine, Science
Abstract

PurposeThe outcome of sarcoma has been suggested in retrospective and non-exhaustive studies to be better through management by a multidisciplinary team of experts and adherence to clinical practice guidelines (CPGs). The aim of this prospective and exhaustive population based study was to confirm the impact of adherence to CPGs on survival in patients with localized sarcoma.Experimental designBetween 2005 and 2007, all evaluable adult patients with a newly diagnosis of localized sarcoma located in Rhone Alpes region (n = 634), including 472 cases of soft-tissue sarcoma (STS), were enrolled. The prognostic impact of adherence to CPGs on progression-free survival (PFS) and overall survival (OS) was assessed by multivariate Cox model in this cohort.ResultsThe median age was 61 years (range 16-92). The most common subtypes were liposarcoma (n = 133, 28%), unclassified sarcoma (n = 98, 20.7%) and leiomyosarcoma (n = 69, 14.6%). In the initial management phase, from diagnosis to adjuvant treatment, the adherence to CPGs for patients with localized STS was 36% overall, corresponding to 56%, 85%, 96% and 84% for initial surgery, radiation therapy, chemotherapy and follow-up, respectively. Adherence to CPGs for surgery was the strongest independent prognostic factor of PFS, along with age, gender, grade, and tumor size. For OS, multivariate analysis adherence to CPGs for surgery was a strong independent prognostic factor, with an important interaction with a management in the regional expert centers.ConclusionsThis study demonstrates impact of CPGs and treatment within an expert center on survival for STS patients in a whole population-based cohort.

Published
2017
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