1. [Antibacterial and antifungal activity of Salvia apiana against clinically important microorganisms].
- Author
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Córdova-Guerrero I, Aragon-Martinez OH, Díaz-Rubio L, Franco-Cabrera S, Serafín-Higuera NA, Pozos-Guillén A, Soto-Castro TA, Martinez-Morales F, and Isiordia-Espinoza M
- Subjects
- Anti-Bacterial Agents isolation & purification, Antifungal Agents isolation & purification, Disk Diffusion Antimicrobial Tests, Dose-Response Relationship, Drug, Drug Evaluation, Preclinical, Hexanes, Plant Extracts isolation & purification, Plant Extracts pharmacology, Plant Roots chemistry, Solvents, Species Specificity, Anti-Bacterial Agents pharmacology, Antifungal Agents pharmacology, Candida drug effects, Gram-Negative Bacteria drug effects, Gram-Positive Bacteria drug effects, Salvia chemistry
- Abstract
Due to the great global concern regarding bacterial resistance to antibiotics, an ongoing search for new molecules having antibacterial activity is necessary. This study evaluated the antibacterial and anticandidal effects of a hexane extract from the root of Salvia apiana. Salvia extracts at concentrations of 27, 13.5, 6.8 and 3.4mg/ml caused growth inhibition of Staphylococcus aureus, Streptococcus pyogenes, Enterococcus faecalis and Candida albicans. However, no significant effect was observed on Escherichia coli and Candida tropicalis in comparison to vehicle. It was here demonstrated for the first time that Salvia apiana has an important antimicrobial effect on human pathogens of great clinical value, thus opening the field to continue the evaluation of this lamiaceous plant for its future use as a therapeutic agent., (Copyright © 2016 Asociación Argentina de Microbiología. Publicado por Elsevier España, S.L.U. All rights reserved.)
- Published
- 2016
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