1. Reactions of Diazo Compounds with Alkenes Catalysed by [RuCl(cod)(Cp)]: Effect of the Substituents in the Formation of Cyclopropanation or Metathesis Products
- Author
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Basato M. 1, Cristina Tubaro 1, Andrea Biffis, 1, Marco Bonato . 1, Gabriella Buscemi, Dr. 1, Filippo Lighezzolo 1, Pamela Lunardi 1, Chiara Vianini 1, Franco Benetollo 2, and Alessandro Del Zotto 3
- Subjects
diazo compounds ,cyclopropanation ,metathesis ,coupling ,ruthenium - Abstract
The reaction of diazo compounds with alkenes catalysed by complex [RuCl(cod)(Cp)] (cod= 1,5-cyclo-octadiene, Cp=cyclopentadienyl) has been studied. The catalytic cycle involves in the first step the decomposition of the diazo derivative to afford the reactive [RuCl(Cp){=C(R-1)R-2}] intermediate and a mechanism is proposed for this step based on a kinetic study of the simple coupling reaction of ethyl diazoacetate. The evolution of the Ru-carbene intermediate in the presence of alkenes depends on the nature of the substituents at both the diazo N-2=C(R-1)R-2 (R-1, R-2 = Ph, H; Ph, CO2Me; Ph, Ph; C(R-1)R-2 = fluorene) and the olefin substrates R-3(H)C=C(H)R-4 (R-3, R-4 = CO2Et, CO2Et; Ph, Ph; Ph, Me; Ph, H; Me, Br; Me, CN; Ph, CN; H, CN; CN, CN). A remarkable reactivity of the complex was recorded, especially towards unstable aryldiazo compounds and electron-poor olefins. The results obtained indicate that either cyclopropanation or metathesis products can be formed: the first products are favoured by the presence of a cyano substituent at the double bond and the second ones by a phenyl.
- Published
- 2009