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229 results on '"Francke, Mike"'

9. Comprehensive automatic processing and analysis of adaptive optics flood illumination retinal images on healthy subjects

Author

Valterová, Eva, Unterlauft, Jan D., Francke, Mike, Toralf, Kirsten, Kolář, Radim, Rauscher, Franziska G., Valterová, Eva, Unterlauft, Jan D., Francke, Mike, Toralf, Kirsten, Kolář, Radim, and Rauscher, Franziska G.

Abstract

This work presents a novel fully automated method for retinal analysis in images acquired with a flood illuminated adaptive optics retinal camera (AO-FIO). The proposed processing pipeline consists of several steps: First, we register single AO-FIO images in a montage image capturing a larger retinal area. The registration is performed by combination of phase correlation and the scale-invariant feature transform method. A set of 200 AO-FIO images from 10 healthy subjects (10 images from left eye and 10 images from right eye) is processed into 20 montage images and mutually aligned according to the automatically detected fovea center. As a second step, the photoreceptors in the montage images are detected using a method based on regional maxima localization, where the detector parameters were determined with Bayesian optimization according to manually labeled photoreceptors by three evaluators. The detection assessment, based on Dice coefficient, ranges from 0.72 to 0.8. In the next step, the corresponding density maps are generated for each of the montage images. As a final step, representative averaged photoreceptor density maps are created for the left and right eye and thus enabling comprehensive analysis across the montage images and a straightforward comparison with available histological data and other published studies. Our proposed method and software thus enable us to generate AO-based photoreceptor density maps for all measured locations fully automatically, and thus it is suitable for large studies, as those are in pressing need for automated approaches. In addition, the application MATADOR (MATlab ADaptive Optics Retinal Image Analysis) that implements the described pipeline and the dataset with photoreceptor labels are made publicly available.

Published
2023

17. Photonic Crystal Light Collectors in Fish Retina Improve Vision in Turbid Water

Author

Kreysing, Moritz, Pusch, Roland, Haverkate, Dorothee, Landsberger, Meik, Engelmann, Jacob, Ruiter, Janina, Mora-Ferrer, Carlos, Ulbricht, Elke, Grosche, Jens, Franze, Kristian, Streif, Stefan, Schumacher, Sarah, Makarov, Felix, Kacza, Johannes, Guck, Jochen, Wolburg, Hartwig, Bowmaker, James K., von der Emde, Gerhard, Schuster, Stefan, Wagner, Hans-Joachim, Reichenbach, Andreas, and Francke, Mike

Published
2012
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20. Additional file 3 of Renal function and lipid metabolism are major predictors of circumpapillary retinal nerve fiber layer thickness���the LIFE-Adult Study

Author

Rauscher, Franziska G., Wang, Mengyu, Francke, Mike, Wirkner, Kerstin, T��njes, Anke, Engel, Christoph, Thiery, Joachim, Stenvinkel, Peter, Stumvoll, Michael, Loeffler, Markus, Elze, Tobias, and Ebert, Thomas

Abstract

Additional file 3: Table S2. Sectoral analyses derived from cpRNFLT in all subjects with further adjustment for high sensitivity c-reactive protein (N = 8,952).

Published
2022
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21. Additional file 6 of Renal function and lipid metabolism are major predictors of circumpapillary retinal nerve fiber layer thickness���the LIFE-Adult Study

Author

Rauscher, Franziska G., Wang, Mengyu, Francke, Mike, Wirkner, Kerstin, T��njes, Anke, Engel, Christoph, Thiery, Joachim, Stenvinkel, Peter, Stumvoll, Michael, Loeffler, Markus, Elze, Tobias, and Ebert, Thomas

Subjects
lipids (amino acids, peptides, and proteins)
Abstract

Additional file 6: Table S5. Sectoral multivariable linear regression analyses for lipid markers and cpRNFLT in all subjects stratified by statin treatment.

Published
2022
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22. Additional file 2 of Renal function and lipid metabolism are major predictors of circumpapillary retinal nerve fiber layer thickness���the LIFE-Adult Study

Author

Rauscher, Franziska G., Wang, Mengyu, Francke, Mike, Wirkner, Kerstin, T��njes, Anke, Engel, Christoph, Thiery, Joachim, Stenvinkel, Peter, Stumvoll, Michael, Loeffler, Markus, Elze, Tobias, and Ebert, Thomas

Subjects
genetic structures, sense organs, eye diseases
Abstract

Additional file 2: Table S1. Sectoral multivariable linear regression analyses for cardiometabolic biomarkers and cpRNFLT in all subjects with further adjustment for SD-OCT-derived clinical and subclinical ONH abnormalities (including glaucoma and other ONH diseases), as well as patient-reported glaucoma diagnosis and medication (N = 8952).

Published
2022
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23. Additional file 8 of Renal function and lipid metabolism are major predictors of circumpapillary retinal nerve fiber layer thickness���the LIFE-Adult Study

Author

Rauscher, Franziska G., Wang, Mengyu, Francke, Mike, Wirkner, Kerstin, T��njes, Anke, Engel, Christoph, Thiery, Joachim, Stenvinkel, Peter, Stumvoll, Michael, Loeffler, Markus, Elze, Tobias, and Ebert, Thomas

Subjects
genetic structures, sense organs, eye diseases
Abstract

Additional file 8: Table S7. Sectoral analyses derived from cpRNFLT in patients with optic nerve head abnormalities, self-reported glaucoma diagnosis, and/or glaucoma medication (N = 1,180).

Published
2022
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24. Additional file 5 of Renal function and lipid metabolism are major predictors of circumpapillary retinal nerve fiber layer thickness���the LIFE-Adult Study

Author

Rauscher, Franziska G., Wang, Mengyu, Francke, Mike, Wirkner, Kerstin, T��njes, Anke, Engel, Christoph, Thiery, Joachim, Stenvinkel, Peter, Stumvoll, Michael, Loeffler, Markus, Elze, Tobias, and Ebert, Thomas

Abstract

Additional file 5: Table S4. Baseline characteristics of the entire study population stratified by statin treatment.

Published
2022
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25. Additional file 4 of Renal function and lipid metabolism are major predictors of circumpapillary retinal nerve fiber layer thickness���the LIFE-Adult Study

Author

Rauscher, Franziska G., Wang, Mengyu, Francke, Mike, Wirkner, Kerstin, T��njes, Anke, Engel, Christoph, Thiery, Joachim, Stenvinkel, Peter, Stumvoll, Michael, Loeffler, Markus, Elze, Tobias, and Ebert, Thomas

Subjects
urologic and male genital diseases, female genital diseases and pregnancy complications
Abstract

Additional file 4: Table S3. Baseline characteristics of the entire study population stratified by CKD risk status.

Published
2022
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26. Additional file 7 of Renal function and lipid metabolism are major predictors of circumpapillary retinal nerve fiber layer thickness���the LIFE-Adult Study

Author

Rauscher, Franziska G., Wang, Mengyu, Francke, Mike, Wirkner, Kerstin, T��njes, Anke, Engel, Christoph, Thiery, Joachim, Stenvinkel, Peter, Stumvoll, Michael, Loeffler, Markus, Elze, Tobias, and Ebert, Thomas

Abstract

Additional file 7: Table S6. Bayesian information criterion difference (��BIC) for the investigation of potential mediating effects of smoking status on the association between cpRNFLT and the lipid profile.

Published
2022
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34. Additional file 1 of Renal function and lipid metabolism are major predictors of circumpapillary retinal nerve fiber layer thickness���the LIFE-Adult Study

Author

Rauscher, Franziska G., Wang, Mengyu, Francke, Mike, Wirkner, Kerstin, T��njes, Anke, Engel, Christoph, Thiery, Joachim, Stenvinkel, Peter, Stumvoll, Michael, Loeffler, Markus, Elze, Tobias, and Ebert, Thomas

Abstract

Additional file 1: Figure S1. Scatterplots illustrating the relationship between global circumpapillary retinal nerve fiber layer thickness (cpRNFLT) and major clinical markers of renal function.

Published
2021
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35. Glutaminyl cyclase inhibition attenuates pyroglutamate Aβ and Alzheimer's disease--like pathology

Author

Schilling, Stephan, Zeitschel, Ulrike, Hoffmann, Torsten, Heiser, Ulrich, Francke, Mike, Kehlen, Astrid, Holzer, Max, Hutter-Paier, Birgit, Prokesch, Manuela, Windisch, Manfred, Jagla, Wolfgang, Schlenzig, Dagmar, Lindner, Christiane, Rudolph, Thomas, Reuters, Gunter, Cynis, Holger, Montag, Dirk, Demuth, Hans-Ulrich, and Rossner, Steffen

Subjects
Control, Care and treatment, Genetic aspects, Research, Health aspects, Glutamine synthetase -- Health aspects -- Control -- Research -- Genetic aspects, Alzheimer's disease -- Genetic aspects -- Care and treatment -- Research, Proteolysis -- Health aspects -- Research -- Genetic aspects, Amyloid beta-protein -- Health aspects -- Genetic aspects -- Research
Abstract

The brains of individuals with Alzheimer's disease are characterized by the presence of neurofibrillary tangles and by deposits of Aβ in neocortical brain structures (1). Sequential β- and γ-secretase cleavage [...], Because of their abundance, resistance to proteolysis, rapid aggregation and neurotoxicity, N-terminally truncated and, in particular, pyroglutamate (pE)-modified Aβ peptides have been suggested as being important in the initiation of pathological cascades resulting in the development of Alzheimer's disease (1-6). We found that the N-terminal pE-formation is catalyzed by glutaminyl cyclase in vivo. Glutaminyl cyclase expression was upregulated in the cortices of individuals with Alzheimer's disease and correlated with the appearance of pE-modified Aβ. Oral application of a glutaminyl cyclase inhibitor resulted in reduced A[β.sub.3(pE)-42] burden in two different transgenic mouse models of Alzheimer's disease and in a new Drosophila model. Treatment of mice was accompanied by reductions in A[β.sub.3(pE)-40/42], diminished plaque formation and gliosis and improved performance in context memory and spatial learning tests. These observations are consistent with the hypothesis that A[β.sub.3(pE)-42] acts as a seed for Aβ aggregation by self-aggregation and co-aggregation with A[β.sub.1-40/42]. Therefore, A[β.sub.3(pE)-40/42] peptides seem to represent A/3 forms with exceptional potency for disturbing neuronal function. The reduction of brain pE-Aβ by inhibition of glutaminyl cyclase offers a new therapeutic option for the treatment of Alzheimer's disease and provides implications for other amyloidoses, such as familial Danish dementia.

Published
2008

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