23 results on '"Francisca Jaime"'
Search Results
2. Per oral endoscopic myotomy (POEM) in pediatric patients with esophageal achalasia: First Latin-American experience
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Fernando Vuletin, Hugo Monrroy, Juan Carlos Pattillo, Allan Sharp, Francisca Jaime, Josefina Sáez, and Ricardo Mejía
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Adult ,Natural Orifice Endoscopic Surgery ,Myotomy ,medicine.medical_specialty ,Adolescent ,medicine.medical_treatment ,Achalasia ,Heller Myotomy ,Esophageal Sphincter, Lower ,otorhinolaryngologic diseases ,medicine ,Humans ,Esophagus ,Child ,Retrospective Studies ,medicine.diagnostic_test ,business.industry ,Incidence (epidemiology) ,General Medicine ,medicine.disease ,Dysphagia ,United States ,Endoscopy ,Surgery ,Esophageal Achalasia ,Treatment Outcome ,medicine.anatomical_structure ,Pediatrics, Perinatology and Child Health ,Cohort ,Laparoscopy ,medicine.symptom ,business ,Esophagitis - Abstract
Background Achalasia is the most common primary motor disorder of the esophagus, but its incidence in pediatric patients is low. Laparoscopic Heller myotomy (LHM) is the current surgical standard of care treatment. Per-oral endoscopic myotomy (POEM) has emerged as a safe and effective therapeutic alternative in adult patients. We herein report the outcomes of a cohort of pediatric patients with achalasia treated by POEM at a Chilean medical center. Methods This is a retrospective analysis of prospectively collected data on children who underwent POEM for esophageal achalasia. Clinical follow-up was evaluated by recording the Eckardt score, a high-resolution esophageal manometry (HREM) three months after the procedure, and an annual upper gastrointestinal endoscopy. Results Five patients with esophageal achalasia confirmed by HREM and with a mean age of 11 (5 to 15) years underwent POEM between 2017 and 2019. One patient had a previous LHM. No morbidity or mortality was observed. All patients resolved their dysphagia and no patient required further interventions. Mean Eckardt score reduced from 10 points preoperatively to 1 point postoperatively. Two patients currently have mild esophagitis (confirmed by endoscopy). Conclusion Our results support the previously reported safety and effectiveness of POEM. Longer follow-up and larger cohorts will be important to confirm its role in the treatment of children with esophageal achalasia. Type of study Treatment study. Level of evidence Level IV.
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- 2021
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3. Fructose Malabsorption in Chilean Children Undergoing Fructose Breath Test at a Tertiary Hospital
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Francisca Jaime, Lorena Rodriguez, Francisco Alliende, Gloria Ríos, Yalda Lucero, and María Eugenia Arancibia
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Adult ,medicine.medical_specialty ,Abdominal pain ,Nausea ,Fructose malabsorption ,Fructose ,Gastroenterology ,Tertiary Care Centers ,03 medical and health sciences ,0302 clinical medicine ,Bloating ,Malabsorption Syndromes ,030225 pediatrics ,Internal medicine ,medicine ,Humans ,Chile ,Child ,Breath test ,medicine.diagnostic_test ,business.industry ,Odds ratio ,medicine.disease ,Fructose Intolerance ,Confidence interval ,Abdominal Pain ,Diarrhea ,Breath Tests ,Pediatrics, Perinatology and Child Health ,030211 gastroenterology & hepatology ,medicine.symptom ,business - Abstract
Fructose is a highly abundant carbohydrate in western diet and may induce bowel symptoms in children as in adults. The main objective of this study is to describe the frequency of fructose malabsorption (FM) in symptomatic patients 18 years or younger undergoing fructose breath test in a single tertiary center between 2013 and 2018, and to evaluate whether certain symptoms are related to positivity of the test. Out of 273 tests 183 (67%) were compatible with FM. The most frequent pretest symptom in the overall study population was bloating (83%), followed by abdominal pain (73%). Patients with positive test were younger than those with a negative test (median 5 vs 8 years, P
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- 2020
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4. [Normal values of eosinophils in gastric and duodenal mucosa of children referred to upper gastrointestinal endoscopy]
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Marlene, Ortiz, Francisca, Jaime, Loreto, Ortiz, Ruby, Carrasco, María José, Orellana, Javiera, Torres, Andrea, Villagrán, and Paul R, Harris
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Eosinophils ,Cross-Sectional Studies ,Adolescent ,Duodenum ,Reference Values ,Child, Preschool ,Stomach ,Humans ,Female ,Intestinal Mucosa ,Child ,Endoscopy, Gastrointestinal - Abstract
With the increasing incidence of food allergies, the presence of eosinophils (Eos) in the gastrointes tinal mucosa has received increased attention, particularly in the esophagus and colon. However, normal values for the Eos count in the stomach and duodenum in pediatric patients are still limited.of this study was to estimate Eos reference values in stomach and duodenal biopsies of children referred to upper gastrointestinal endoscopy.Cross-sectional study of biopsies from symptomatic children referred to upper gastrointestinal endoscopy. The endoscopic report, Rapid Urease Test for the presence of H. pylori, and the quantitative histological evaluation (number of cells/HFP, high power field) were analyzed. The Eos distribution is described as mean and standard deviation, and also as percentiles since the counts did not have a normal distribution. Statistical analysis included x2 test, Wilcoxon test, analysis of variance, and linear regression curves were evaluated as appropriate.Of the 170 patients referred to endoscopy, 72 met "normal" criteria (normal endoscopy in macroscopic analysis, negative Rapid Urease Test, and normal biop sy). The median age was 11 years (range 4-16), and 68% were girls. The Eos count (mean ± 1SD) in gastric antrum (n = 72) was 1.13 ± 1.79 Eos/HPF; in gastric body (n = 27), 1.06 ± 1.79 Eos/HPF; and in duodenum (n = 30), 10.44 ± 7.09 Eos/HPF. There were no significant differences by age and sex, or by H. pylori infection (p = 0.095).We propose an Eos count of 0-3 Eos/HPF for the gastric body, 0-3 Eos/HPF in the antrum, and 3-17 Eos/HPF in the duodenum as a normal range for gastric mucosa in children. This study suggests that in areas with a high prevalence of H. pylori infec tion, the count of Eos does not seem to be a distinctive element and that Eos are commonly present in the gastroduodenal mucosa.
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- 2020
5. Gastroesophageal Reflux and Respiratory Diseases
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José San Martín Prieto, María Francisca Jaime Méndez, and Juan Cristóbal Gana Ansaldo
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medicine.medical_specialty ,business.industry ,Subglottic stenosis ,fungi ,Apnea ,Disease ,medicine.disease ,Gastroenterology ,Obstructive sleep apnea ,Chronic cough ,Internal medicine ,medicine ,Laryngomalacia ,medicine.symptom ,Airway ,business ,Asthma - Abstract
Gastroesophageal reflux (GER) is considered to be a physiological event in most cases, but should be differentiated from disease caused by GER, where symptoms or complications are present. Direct contact between gastric juice and its components with the airway may cause damage to these structures, which can lead to association with multiple respiratory diseases (asthma, chronic cough, aspiration disorders, apnea, subglottic stenosis, etc.); however, in most of them causality has not been confirmed. The diagnosis of disease caused by GER may be complex when symptoms are subtle or prolonged, and should be suspected in children with compatible symptoms, feeding problems, non-explained airway problems or lack of response to treatment. Complementary tests can be useful, but should be reserved when there is a specific clinical question. Proton pump inhibitors are considered first choice for suppression of acid effect and to treat erosive esophagitis. Surgery can be considered in situations such as failure of optimal medical therapy, though there is limited evidence in children.
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- 2020
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6. Valores de normalidad de eosinófilos en mucosa gástrica y duodenal de niños referidos a endoscopía digestiva alta
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Francisca Jaime, María José Orellana, Marlene Ortiz, Javiera Torres, Loreto Ortiz, Paul R. Harris, Ruby Carrasco, and Andrea Villagrán
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Pediatrics, Perinatology and Child Health - Abstract
Con el aumento de la incidencia de alergias alimentarias, la presencia de eosinófilos (Eos) en la mucosa gastrointestinal ha recibido mayor atención. Sin embargo, los valores de normalidad para el recuento de Eos en estómago y duodeno en pacientes pediátricos son aún limitados.Objetivo: Estimar valores de referencia de Eos en biopsias de estómago y duodeno de niños referidos a endoscopía digestiva alta (EDA).Pacientes y Método: Estudio transversal de biopsias de niños referidos a EDA. Se analizó el informe endoscópico, test de ureasa para presencia de H. pylori y evaluación histológica (nº células/campo de aumento mayor o CAM). Se describe la distribución de Eos como mediana y desviación estandar, así como también la distribución percentilar, dado que los recuentos no tuvieron distribución normal. Se realizó análisis estadístico con test χ2 , test de Wilcoxon, análisis de la varianza y curvas de regresión lineal según correspondiera.Resultados: De 170 pacientes derivados a EDA, 72 cumplían con criterios de “normalidad” (EDA normal en análisis macroscópico, test de ureasa negativo y biopsia normal). La mediana de edad fue 11 años (rango 4-16), 68% niñas. El recuento de Eos (promedio ± 1DE) en cuerpo gástrico (n = 27) fue 1,06 ± 1,79 Eos/CAM, en antro gástrico (n = 72) fue 1,13 ± 1,79 Eos/HPF, y en duodeno (n = 30) fue 10,44 ± 7,09 Eos/CAM. No se encontraron diferencias significativas por edad y sexo, así como tampoco según infección por H. pylori (p = 0,095).Conclusiones: Se propone como rango de referencia en niños un conteo en cuerpo gástrico de 0-3 Eos/CAM, en antro de 0-3 Eos/CAM y en duodeno de 3-17 Eos/CAM. Incluso en medios con alta prevalencia de infección por H. pylori, el recuento de Eos no parece ser un elemento distintivo, y éstos están presentes normalmente en la mucosa gastroduodenal.
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- 2021
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7. Functional gastrointestinal disorders in children from low socio-economic status and Helicobacter pylori infection
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Francisca Jaime, Carolina Serrano, Andrea Villagrán, Marlene Ortiz, Paul R. Harris, and Cherie Hernandez
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Male ,Abdominal pain ,medicine.medical_specialty ,Adolescent ,Gastrointestinal Diseases ,Cross-sectional study ,Urea breath test ,Helicobacter Infections ,Young Adult ,03 medical and health sciences ,Sex Factors ,0302 clinical medicine ,Risk Factors ,Stomach Neoplasms ,030225 pediatrics ,Internal medicine ,Prevalence ,Developmental and Educational Psychology ,medicine ,Humans ,Genetic Predisposition to Disease ,Chile ,Young adult ,Family history ,Child ,Aerophagia ,Helicobacter pylori ,medicine.diagnostic_test ,biology ,business.industry ,Public Health, Environmental and Occupational Health ,medicine.disease ,biology.organism_classification ,Cross-Sectional Studies ,Breath Tests ,Social Class ,Pediatrics, Perinatology and Child Health ,Educational Status ,Functional constipation ,Female ,030211 gastroenterology & hepatology ,medicine.symptom ,business - Abstract
BACKGROUND Most studies on functional gastrointestinal disorders (FGIDs) in children are based on data from the northern hemisphere. Scientific reports are arising in South American population, but little is still known about children from low socio-economic status (SES), where Helicobacter pylori infection is endemic. Our objective was to evaluate the prevalence of FGIDs in school children from low SES and its relationship with H. pylori infection. METHODS Children from 3 public schools of low SES from Santiago de Chile were included. Students completed the Rome III Questionnaire and a survey about other symptoms. Also, the 13 C urea breath test determined the presence of H. pylori infection. RESULTS Five hundred six children were included, where 48% were male, with a median age of 15.7 years (range 7.1-19.6). Forty-two percent had some FGID, aerophagia and functional constipation being the most frequent. Females (adjusted OR 1.5, 95% CI [1.1, 2.2]), those children with parents within the lowest level of education (adjusted OR 1.6, 95% CI: 1.1-2.4), and family history of gastric cancer (adjusted OR 1.9, 95% CI: 1.2-3.1) were related to FGIDs. The prevalence of H. pylori infection was 55.9% (95% CI [50.7, 60.9]). In multivariable analysis, the presence of abdominal pain (OR 1.55, 95% CI [1.02, 2.36]), but not FGIDs, was related to H. pylori infection. CONCLUSIONS FGIDs are common in low SES students. A low educational level of the household head, family history of gastric cancer. and being female are related to the development of FGIDs. In this study, no relationship between the presence of H. pylori and FGIDs was found.
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- 2017
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8. Muscle wasting in male TNF-α blocker naïve ankylosing spondylitis patients: a comparison of gender differences in body composition
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I.M. Visman, Willem F. Lems, Sebastian Ibanez Vodnizza, Michael T. Nurmohamed, Francisca Jaime, Christiaan J. van Denderen, Irene E. van der Horst-Bruinsma, Rheumatology, Amsterdam Movement Sciences - Rehabilitation & Development, AII - Inflammatory diseases, and ACS - Atherosclerosis & ischemic syndromes
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Adult ,Male ,medicine.medical_specialty ,Percentile ,Adipose tissue ,030209 endocrinology & metabolism ,Severity of Illness Index ,Body fat percentage ,03 medical and health sciences ,Absorptiometry, Photon ,0302 clinical medicine ,Rheumatology ,Internal medicine ,medicine ,Humans ,Spondylitis, Ankylosing ,Pharmacology (medical) ,Prospective Studies ,BASDAI ,Wasting ,Dual-energy X-ray absorptiometry ,Aged ,Dyslipidemias ,030203 arthritis & rheumatology ,Sex Characteristics ,Ankylosing spondylitis ,medicine.diagnostic_test ,Tumor Necrosis Factor-alpha ,business.industry ,Anti-Inflammatory Agents, Non-Steroidal ,Middle Aged ,medicine.disease ,Muscular Atrophy ,Endocrinology ,Adipose Tissue ,Antirheumatic Agents ,Hypertension ,Cohort ,Body Composition ,Female ,medicine.symptom ,business - Abstract
Objective: To assess gender differences in body composition (BC) in a cohort of AS patients naïve to TNF-α blockers.Methods: Patients included fulfilled the Modified New York criteria for AS. Demographic information and disease activity measures (ASDAS and BASDAI) were reported. BC was measured by whole body DXA. Body fat percentage (BF%), fat mass index (FMI), fat free mass index (FFMI) and android/gynoid fat ratio were reported and compared between men and women and with the reference population (percentiles).Results: Seventy consecutive patients were included; 60% were men. Demographic variables were similar, except for dyslipidaemia (57.1% of men; 14.3% of women). Women had significantly more fat (BF%, FMI), and less muscle (FFMI) than men, but below the median of the reference population. Male AS patients had a markedly low FFMI (31.7th percentile) compared with the reference population. In the whole group, after multivariate analysis, an ASDAS CRP >3.5 was related to lower fat free mass content. In men, a significant relationship between having a high disease activity (ASDAS, BASDAI) and lower BF% or FMI percentile was found, but in women it was the opposite.Conclusion: Muscle wasting, measured as low FFMI compared with the reference population, was found in male TNF-α blocker naïve AS patients, especially in those with active disease. Women had higher volumes of body fat than men, but near the median of the reference population. The relationships between fat content and disease activity support the complex association between adipose tissue and inflammation.
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- 2017
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9. Per oral endoscopic myotomy in a pediatric patient with achalasia
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Ricardo, Mejía, Josefina, Sáez, Francisco, Aranda, Juan Carlos, Pattillo, José Fernando, Vuletin, Daniela, Gattini, María Francisca, Jaime, and Allan, Sharp
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Esophageal Achalasia ,Male ,Pyloromyotomy ,Humans ,Child - Abstract
Achalasia is the most common primary motor disorder of the esophagus. Its reported incidence is low, even more in pediatric patients. Laparoscopic Heller myotomy is the current stan dard of treatment. During the last years, per-oral endoscopic myotomy (POEM) has been positioned as a safe and effective therapeutic alternative as the Heller procedure for esophageal achalasia. Ob jective: To describe the POEM technique and report the first pediatric case in our country.11-year-old patient, previously healthy, who presented with progressive dysphagia for solids and liquids and weight loss. The study concluded a type II achalasia. The patient underwent a POEM and had a postoperative course without incidents. One year after the intervention, symptomatic, endoscopic and manometric resolution have been documented.The described case is the first POEM in a pediatric patient in our country. Esophageal achalasia is uncommon in pediatrics and POEM has demonstrated clinical success and safety comparable to laparoscopic Heller myotomy in short and medium term. Long-term follow-up will determine its definitive role in the treatment of pediatric patients with esophageal achalasia.
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- 2018
10. Evaluación de presencia y severidad de periodontitis en pacientes chilenos con artritis reumatoide atendidos en el Hospital Padre Hurtado
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Francisca Jaime, Omar Valenzuela L, Nicolás Giadalah, Elena Jarpa, Sebastián Ibáñez, Vicente Jara, Cristina Ferreiro, and Andrés Contreras
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Periodontitis ,Gynecology ,medicine.medical_specialty ,business.industry ,Severity of illness ,medicine ,General Medicine ,medicine.disease ,business - Abstract
ResidenteMedicinaInterna,� FacultaddeMedicinaClinica� Alemana-Universidaddel� Desarrollo. 4 Gastroenterologapediatrica,� PontificiaUniversidadCatolica� deChile. a EstudianteOdontologia,� FacultaddeMedicinaClinica� Alemana-Universidaddel� Desarrollo. b DocenteOdontologia,�Facultad� deMedicinaClinicaAlemana- UniversidaddelDesarrollo.
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- 2015
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11. Final Diagnosis of Pediatric Patients with Prolonged in Activated Partial Thromboplastin Time Preoperative Study
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Noemí Aguirre, Pamela Zúñiga, Francisca Jaime, Francisca Córdova, and Ximena Fonseca
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medicine.medical_specialty ,Lupus anticoagulant ,medicine.diagnostic_test ,business.industry ,medicine.medical_treatment ,medicine.disease ,Surgery ,Tonsillectomy ,Adenoidectomy ,Internal medicine ,medicine ,Coagulopathy ,Von Willebrand disease ,Coagulation testing ,business ,Coagulation Disorder ,circulatory and respiratory physiology ,Partial thromboplastin time - Abstract
Introduction: Activated partial thromboplastin time (aPTT) is one of the most used coagulation tests in preoperative evaluation. Incidental detection of a prolonged aPTT is a problem in primary care, in which the general pediatrician should be able to attend its initial management. Objective: To describe final diagnosis of patients with prolonged aPTT in preoperative study. Materials and Methods: This is a descriptive study of patients referred from otorhinolaryngology. Results: Totally, 508 adenoidectomies and/or tonsillectomies were performed in our center, 38 of which referred patients (7.5%) with prolonged aPTT, and 30 of which met inclusion criteria. The median age was 4 years. 56.6% of patients were males. 76.6% of patients normalized aPTT at the second follow-up. Among these, 73.9% showed a normal study, 4.3% ha2d lupus anticoagulant and in 21.7% Von Willebrand disease was detected. Among patients that persisted with prolonged aPTT, 42.8% had coagulant factors deficiency, 28.5% had lupus anticoagulant and in 28.5% of patients a diagnosis could not be achieved with the tests used in the present study. Multivariate analysis did not show correlation between final diagnosis and the variables measured. Conclusion: The presence of a prolonged aPTT in children under preoperative study is due to a pre-analytic factor in the majority of cases or to the presence of lupus anticoagulant, normalizing values on follow-up. We suggest that a new aPTT be performed on these patients, and only those that persist altered or present a symptoms and family history of coagulation disorders be referred to hematology.
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- 2015
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12. Fat mass lowers the response to tumor necrosis factor-a blockers in patients with ankylosing spondylitis
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Sebastián E Ibáñez Vodnizza, J Christiaan van Denderen, Irene E van der Horst-Bruinsma, Michael T Nurmohamed, I.M. Visman, Willem F Lems, Francisca Jaime, Rheumatology, ACS - Atherosclerosis & ischemic syndromes, AII - Inflammatory diseases, and Amsterdam Movement Sciences - Rehabilitation & Development
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Adult ,Male ,medicine.medical_specialty ,Percentile ,Immunology ,030209 endocrinology & metabolism ,Body fat percentage ,Gastroenterology ,Etanercept ,03 medical and health sciences ,0302 clinical medicine ,Absorptiometry, Photon ,Rheumatology ,Interquartile range ,Internal medicine ,medicine ,Adalimumab ,Immunology and Allergy ,Humans ,Spondylitis, Ankylosing ,BASDAI ,Adiposity ,030203 arthritis & rheumatology ,Ankylosing spondylitis ,business.industry ,Tumor Necrosis Factor-alpha ,Middle Aged ,medicine.disease ,Endocrinology ,C-Reactive Protein ,Treatment Outcome ,Adipose Tissue ,Antirheumatic Agents ,Tumor necrosis factor alpha ,Female ,business ,medicine.drug - Abstract
Objective.Our main objective was to assess the relationship between body composition (BC) and response to tumor necrosis factor-α (TNF-α) blocker treatment in patients with ankylosing spondylitis (AS). Our secondary objective was to evaluate the change of BC after treatment, accounting for sex and age.Methods.All included patients fulfilled the modified New York criteria for AS and were naive to TNF-α blocker. They were followed for at least 6 months after the start of etanercept or adalimumab. The Ankylosing Spondylitis Disease Activity Score containing C-reactive protein (ASDAS-CRP) and the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) were reported. BC was assessed by whole body dual-energy X-ray absorptiometry. Body fat percentage (BF%), fat mass index (FMI), and fat free mass index (FFMI) were reported as absolute values and as percentiles.Results.Forty-one patients were included (61% men). The median followup was 14.3 months (interquartile range 8.4–19.4). After multivariate regression analysis, more fat at baseline (BF%, FMI, or FMI percentile) was significantly related with a lower chance of achieving a clinically important improvement of the ASDAS-CRP or BASDAI after treatment. The body composition did not change significantly after treatment, but there was a trend toward muscle recovery in men (FFMI change from 34.0th to 37.4th percentile).Conclusion.Higher body fat content at baseline was independently associated with a worse response to treatment with TNF-α blockers, measured by ASDAS-CRP and BASDAI change, and might contribute to the lower response rates in female patients. Also, there is a trend toward muscle mass recovery in male patients after treatment.
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- 2017
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13. Solar radiation is inversely associated with inflammatory bowel disease admissions
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Carlos A. Camargo, Francisca Jaime, Arturo Borzutzky, Rodrigo Hoyos-Bachiloglu, Maria C. Riutort, and Manuel Álvarez-Lobos
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,Population ,Disease ,Gastroenterology ,Inflammatory bowel disease ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Age Distribution ,Patient Admission ,Crohn Disease ,Internal medicine ,medicine ,Vitamin D and neurology ,Humans ,030212 general & internal medicine ,Registries ,Chile ,Sex Distribution ,education ,Child ,Health statistics ,Aged ,Aged, 80 and over ,education.field_of_study ,Crohn's disease ,business.industry ,Infant, Newborn ,Ecological study ,Infant ,Middle Aged ,medicine.disease ,Vitamin D Deficiency ,Ulcerative colitis ,digestive system diseases ,Child, Preschool ,Multivariate Analysis ,Linear Models ,Sunlight ,030211 gastroenterology & hepatology ,Colitis, Ulcerative ,Female ,Seasons ,business - Abstract
Objective: To explore the associations between latitude and solar radiation with inflammatory bowel disease admission rates in Chile, the country with the largest variation in solar radiation in the world. Patients and methods: This is an ecological study, which included data on all hospital-admitted population for inflammatory bowel disease between 2001 and 2012, according to different latitudes and solar radiation exposures in Chile. The data were acquired from the national hospital discharge database from the Department of Health Statistics and Information of the Chilean Ministry of Health. Results: Between 2001 and 2012 there were 12,869 admissions due to inflammatory bowel disease (69% ulcerative colitis, 31% Crohn’s disease). Median age was 36 years (IQR: 25–51); 57% were female. The national inflammatory bowel disease admission rate was 6.52 (95% CI: 6.40–6.63) per 100,000 inhabitants with increasing rates over the 12-year period. In terms of latitude, the highest admission rates for pediatric ulcerative colitis and Crohn’s disease, as well as adult ulcerative colitis, were observed in the southernmost region with lowest annual solar radiation. Linear regression analysis showed that regional solar radiation was inversely associated with inflammatory bowel disease admissions in Chile (β: −.44, p = .03). Conclusions: Regional solar radiation was inversely associated with inflammatory bowel disease admission rates in Chile; inflammatory bowel disease admissions were highest in the southernmost region with lowest solar radiation. Our results support the potential role of vitamin D deficiency on inflammatory bowel disease flares.
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- 2017
14. Prevalencia de la infección por Helicobacter pylori en niños: estimando la edad de adquisición
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Andrea Villagrán, Francisca Jaime, Carolina Serrano, Paul R. Harris, and Jaime Cerda
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Gerontology ,Helicobacter pylori infection ,School age child ,Helicobacter pylori ,biology ,Cross-sectional study ,business.industry ,Breastfeeding ,General Medicine ,biology.organism_classification ,Elisa kit ,Prevalence ,Medicine ,Positive test ,Child ,business ,Socioeconomic status ,Demography - Abstract
Background: A 73% prevalence of Helicobacter pylori infection was estimated in adults in the 2003 Chilean National Health Survey. However, this infection is usually acquired during childhood. Aim: To determine the frequency of H. pylori infection in healthy Chilean children from a school in Santiago. Material and Methods: A cross sectional study in a private/ subsidized school in Santiago. Children aged less than 18 years were invited to participate. The parents of those who accepted answered a demographic survey and a stool sample was obtained from participants to detect H. pylori antigen using a monoclonal antibody ELISA kit. Results: We studied 144 students aged 10.6 ± 3.1 years (54% females). Twenty six participants (18.1%, 95% CI: 12.4-24.9%) had a positive test. Children from higher socioeconomic levels had a non-significant lower frequency of infection. No differences in the frequency of infection were observed by age, gender, household type or number of people living in it or history of breastfeeding. Conclusions: In this sample of children, an 18.1% frequency of H. pylori infection was observed.
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- 2013
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15. [Frequency and severity of periodontitis among patients with rheumatoid arthritis]
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Sebastián, Ibáñez V, Cristina, Ferreiro, Andrés, Contreras, Omar, Valenzuela L, Nicolás, Giadalah, Vicente, Jara, Francisca, Jaime, and Elena, Jarpa
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Adult ,Arthritis, Rheumatoid ,Male ,Cross-Sectional Studies ,Risk Factors ,Humans ,Female ,Middle Aged ,Periodontitis ,Severity of Illness Index ,Aged - Abstract
Periodontitis may have a triggering and aggravating role of various medical conditions, including rheumatoid arthritis.To evaluate the periodontal status in Chilean patients with rheumatoid arthritis (RA), treated in a public hospital.A trained professional conducted a periodontal examination in 40 patients with RA aged 23 to 73 years (85% women). When present, the severity of periodontitis and its relationship with gender, smoking, age, corticosteroids dose and AR activity were assessed. AR activity was evaluated using the Disease Activity Score Calculator for Rheumatoid Arthritis (DAS 28).Thirty five of the 40 patients had periodontitis and in 13, it was severe. Men, smokers, and older patients had more severe stages. Patients using higher doses of corticosteroids had lower severity of periodontitis. No relationship between the severity of periodontitis and AR activity was found.Periodontitis is common and severe in patients with RA, and is influenced by gender, age, smoking and corticosteroid dose.
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- 2015
16. Concordance between Lactose Quick Test, hydrogen-methane breath test and genotyping for the diagnosis of lactose malabsorption in children
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Francisca Jaime, Andrea Villagrán, C. Rojo, Cherie Hernandez, G. Arancibia, L. Azócar, and Juan Francisco Miquel
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Male ,Abdominal pain ,medicine.medical_specialty ,Malabsorption ,Adolescent ,Genotype ,Physiology ,Concordance ,Polymorphism, Single Nucleotide ,Gastroenterology ,03 medical and health sciences ,chemistry.chemical_compound ,Lactose Intolerance ,0302 clinical medicine ,Internal medicine ,Humans ,Medicine ,Genetic Testing ,030212 general & internal medicine ,Lactose ,Child ,Genotyping ,Pediatric gastroenterology ,Lactase ,Breath test ,Lactose intolerance ,medicine.diagnostic_test ,Endocrine and Autonomic Systems ,business.industry ,medicine.disease ,Cross-Sectional Studies ,Breath Tests ,chemistry ,Female ,030211 gastroenterology & hepatology ,medicine.symptom ,business - Abstract
BACKGROUND Lactose intolerance is a frequent condition in certain populations. Different methods for diagnosis exist. There is scarce literature regarding Lactose Quick Test (LQT) and concordance with other methods for lactose intolerance diagnosis in children. METHODS Prospectively, we included children who underwent gastroduodenoscopy for evaluation of abdominal pain. We obtained a duodenal sample for LQT and blood sample for genetic test to evaluate LCT C>T-13910 variant. Later, patients underwent breath test with lactose, to evaluate malabsorption. We evaluated the concordance between the three different tests. KEY RESULTS We included 46 patients, 56.5% women. Mean age was 13.2 years (range 9-18 years). 66.6% of patients had lactose malabsorption according to breath test; 64.4% were homozygous CC; and 91.3% had hypolactasia (mild or severe) according to LQT. None of the patients with normolactasia had altered breath test. Genetic test had a substantial agreement (k = 0.675) with breath test and fair agreement (k = 0.301) with LQT. LQT had fair agreement (k = 0.348) with breath test. CONCLUSIONS & INFERENCES Genetic test had better concordance with breath test than LQT to diagnose lactose malabsorption, however, none of the patients with normal LQT had lactose malabsorption. In patients who undergo gastroduodenoscopy to study abdominal pain, it seems reasonable to perform LQT, and, in those with hypolactasia, to perform breath test.
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- 2017
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17. [Frequency of Helicobacter pylori infection in 144 school age Chilean children]
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Francisca, Jaime, Andrea, Villagrán, Carolina, Serrano, Jaime, Cerda, and Paul R, Harris
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Male ,Schools ,Adolescent ,Helicobacter pylori ,Enzyme-Linked Immunosorbent Assay ,Helicobacter Infections ,Age Distribution ,Cross-Sectional Studies ,Socioeconomic Factors ,Child, Preschool ,Surveys and Questionnaires ,Prevalence ,Humans ,Female ,Private Sector ,Chile ,Child - Abstract
A 73% prevalence of Helicobacter pylori infection was estimated in adults in the 2003 Chilean National Health Survey. However, this infection is usually acquired during childhood.To determine the frequency of H. pylori infection in healthy Chilean children from a school in Santiago.A cross sectional study in a private/ subsidized school in Santiago. Children aged less than 18 years were invited to participate. The parents of those who accepted answered a demographic survey and a stool sample was obtained from participants to detect H. pylori antigen using a monoclonal antibody ELISA kit.We studied 144 students aged 10.6 ± 3.1 years (54% females). Twenty six participants (18.1%, 95% CI: 12.4-24.9%) had a positive test. Children from higher socioeconomic levels had a non-significant lower frequency of infection. No differences in the frequency of infection were observed by age, gender, household type or number of people living in it or history of breastfeeding.In this sample of children, an 18.1% frequency of H. pylori infection was observed.
- Published
- 2012
18. Marcadores de síndrome metabólico como predictores de elevación de alanino aminotransferasa en niños
- Author
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Gabriel Arancibia, Paul R. Harris, Francisca Jaime, Rodrigo Bancalari, and Hernán García
- Subjects
medicine.medical_specialty ,Waist ,biology ,business.industry ,Fatty liver ,General Medicine ,medicine.disease ,Asymptomatic ,Obesity ,Gastroenterology ,Blood pressure ,Endocrinology ,Alanine transaminase ,Metabolic syndrome X ,Internal medicine ,medicine ,biology.protein ,medicine.symptom ,Metabolic syndrome ,business ,Child ,Body mass index - Abstract
Background: There is a high prevalence of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) among pediatric patients. The identification of clinical predictors of these conditions would allow a timely treatment. Aim: To evaluate the relationship between serum alanine aminotransferase levels and parameters of metabolic syndrome in asymptomatic school students without hepatic illness. Subjects and Methods: A randomized sample of 175 children aged between 9 and 14 years (54% females) was selected, from a database of 3010 students living in Santiago, Chile. Weight, height, abdominal circumference, systolic and diastolic blood pressure were measured. A fasting blood sample was obtained to measure glucose, total cholesterol, HDL, LDL-cholesterol, triglycerides, alanine aminotransferase (ALT) and insulin levels. Results: Forty percent of participants were obese, 17% had metabolic syndrome and 13.1% had abnormal ALT levels. Compared with children with normal ALT levels, the latter had significantly higher waist obesity, body mass index, systolic and diastolic blood pressure and triglycerides. However on multiva-riate analysis, only waist obesity was independently associated with abnormal ALT levels (adjusted odds ratio 3.93, 95% confidence intervals 1.44-10.78, p = 0.008). Conclusions: Only waist obesity was independently associated with abnormal ALT levels in this sample of children.
- Published
- 2012
19. Efecto de la hospitalización sobre la mantención de la lactancia materna en niños menores de 6 meses de edad
- Author
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María Soto B, Ingrid Cardoso K, Daniela Carrillo, Francisca Jaime M, and Gonzalo Menchaca O
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Gerontology ,medicine.medical_specialty ,Obstetrics ,Post discharge ,business.industry ,Lactancia materna ,Breastfeeding ,After discharge ,pediatría ,Pediatrics, Perinatology and Child Health ,medicine ,hospitalización ,In patient ,Pediatric unit ,business ,Breast feeding ,Cohort study - Abstract
Objetivo: Evaluar el efecto de la hospitalización por morbilidad aguda sobre la continuidad de la lactancia materna (LM) en menores de 6 meses de edad. Pacientes y Método: Estudio de cohorte concurrente en pacientes ingresados al Hospital Sótero del Río, con seguimiento de lactancia materna al ingreso, a las 2 y 6 semanas post-alta. Resultados: 72 pacientes ingresaron al estudio. Al momento de la admisión, 91,7% de los pacientes recibía LM, de ellos, 19,4% era lactancia materna exclusiva (LME). A las 2 semanas post alta, LM y LME fue de 86% y 29% (p = NS), respectivamente. A las 6 semanas post alta, LM y LME fue de 80% (p = 0,021 respecto al ingreso), y 33% (p = NS) respectivamente. En los pacientes ingresados a sala, se observó un aumento en la LME entre la segunda y la sexta semana de seguimiento (29,7% y 40,5%, respectivamente, p = 0,008). Conclusiones: Posterior al alta, se observó una disminución en la prevalencia de LM similar a la caída observada en la Encuesta Nacional de Lactancia Materna. La hospitalización no afectó negativamente la mantención de la lactancia materna, al contrario, se observó un incremento en aquellos que recibían lactancia materna exclusiva, lo que podría explicarse por la educación en lactancia que reciben las madres durante la hospitalización.
- Published
- 2012
20. [Association of metabolic syndrome markers with abnormal alanine aminotransferase levels in healthy children]
- Author
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Gabriel, Arancibia, Hernán, García, Francisca, Jaime, Rodrigo, Bancalari, and Paul R, Harris
- Subjects
Male ,Metabolic Syndrome ,Adolescent ,Alanine Transaminase ,Blood Pressure ,Body Mass Index ,Fatty Liver ,Non-alcoholic Fatty Liver Disease ,Obesity, Abdominal ,Humans ,Female ,Chile ,Waist Circumference ,Child ,Biomarkers - Abstract
There is a high prevalence of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) among pediatric patients. The identification of clinical predictors of these conditions would allow a timely treatment.To evaluate the relationship between serum alanine aminotransferase levels and parameters of metabolic syndrome in asymptomatic school students without hepatic illness.A randomized sample of 175 children aged between 9 and 14 years (54% females) was selected, from a database of 3010 students living in Santiago, Chile. Weight, height, abdominal circumference, systolic and diastolic blood pressure were measured. A fasting blood sample was obtained to measure glucose, total cholesterol, HDL, LDL-cholesterol, triglycerides, alanine aminotransferase (ALT) and insulin levels.Forty percent of participants were obese, 17% had metabolic syndrome and 13.1% had abnormal ALT levels. Compared with children with normal ALT levels, the latter had significantly higher waist obesity, body mass index, systolic and diastolic blood pressure and triglycerides. However on multivariate analysis, only waist obesity was independently associated with abnormal ALT levels (adjusted odds ratio 3.93, 95% confidence intervals 1.44-10.78, p = 0.008).Only waist obesity was independently associated with abnormal ALT levels in this sample of children.
- Published
- 2011
21. Curvas Manométricas Rectales en Niños: Estudio Promano Fase I
- Author
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Silvana Saavedra G, Francisca Jaime M, Paul R. Harris, Juan Cristóbal Gana A, and Francisco Larraín B
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medicine.medical_specialty ,Chronic constipation ,Constipation ,business.industry ,Megarectum ,Anorectal manometry ,medicine.disease ,Gastroenterology ,Phase i study ,Surgery ,Defecation disorders ,Manometría ,pediatría ,Internal medicine ,Pediatrics, Perinatology and Child Health ,medicine ,constipación ,medicine.symptom ,business - Abstract
Propósito del estudio: Evaluar el rol de la manometría rectoanal (MRA) y establecer valores de normalidad en un grupo de niños referidos por desórdenes de defecación. Pacientes y Métodos: Revisión retrospectiva de MRA efectuadas durante un período de 8 años. Resultados: Se analizaron los resultados obtenidos de 789 niños (52,6% hombres). Éstos se clasificaron en cuatro grupos según resultado de la MRA como "Grupo control" (CL), "Grupo con probable megarrecto" (PMG), "Grupo con anormalidades de la inervación intrínseca" (All) y "Grupo con anormalidades de la inervación extrínseca" (ALE). Setenta y nueve porciento de los pacientes fueron referidos para evaluación de constipación crónica y 10% por sospecha de anormalidades de inervación intrínseca; en 94% y 83% de ellos respectivamente, la MRA descartó causas orgánicas. Los niños se distribuyeron en: CL (48,0%), PMG (42,6%), All (7,5%) y AIE (1,5%). El grupo CL y PMG mostraron diferencias edad-dependiente en algunos parámetros manométricos. Además se encontró diferencias en parámetros manométricos entre CL, PMG, All y AIE. Conclusiones: La principal indicación de MRA fue para estudio de constipación crónica, siendo las alteraciones orgánicas confirmadas sólo en un bajo porcentaje. Se describió cuatro patrones diferentes en 789 pacientes referidos para evaluación de dificultades en la defecación.
- Published
- 2009
22. Evaluación de los índices de monitoreo de pH esofágico y su relación con indicaciones clínicas: MePeache Fase I
- Author
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Paul Harris D, Ernesto Guiraldes C, Francisca Jaime M, Francisco Larraín B, Silvana Saavedra G, and Juan Cristóbal Gana A
- Subjects
índice de pHmetría ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Otolaryngologic Diseases ,pH monitoring ,gastroesophageal reflux ,Reflux ,Ph monitoring ,Gastroenterology ,Normal group ,Weak correlation ,pHmetría ,Clinical diagnosis ,Internal medicine ,Pediatrics, Perinatology and Child Health ,Medicine ,business ,Esophageal pH monitoring ,reflujo gastroesofágico ,pH-metric index - Abstract
Objetivos: Establecer valores promedio y rangos de normalidad de parámetros pHmétricos diferentes al Índice de Reflujo (IR) en monitoreos de pH esofágico (MpHe), según nuevos valores de IR y correlacionarlos con el diagnóstico clínico. Pacientes y Método: Estudio retrospectivo de parámetros de MpHe incluyendo IR, nº y duración de episodios (DPE), nº episodios > 5 min y duración episodio mayor. Se reagrupó a los 153 pacientes según edad (Grupo I < 1 año y Grupo II > 1 año) y según IR como: Grupo Normal (NL) a aquéllos con IR en rango fisiológico (IR < 12% GI y < 6% GII) y Grupo Patológico (PT), cuando el IR superaba estos valores. Resultados: Las indicaciones más frecuentes fueron estudio de RGE (41,7%), patología de vías aéreas (19,9%) y otorrinolaringológicas (17,2%). Al comparar MpHes en GI (n = 53) no se encontraron diferencias significativas según género, médico referente o indicación. En el Grupo NL de GII (n = 100) se encontró un IR en niños referidos por pediatras mayor al de aquellos referidos por gastroenterólogos (p = 0,002). Según grupos NL y PT, todos los parámetros pHmétricos resultaron significativos (p < 0,005), excepto la DPE. 84,9% y 77% de los MpHes en GI y GII, respectivamente fueron normales. Conclusión: Los índices de MpHe permiten separar los grupos NL y PT bajo los nuevos puntos de corte del IR. Existe escaso correlato entre sospecha clínica y diagnóstico pHmétrico lo que sugiere la necesidad de reevaluar sus indicaciones clínicas Objectives: Establish mean values and normality range for pH metric parameters, different to reflux index (RI), in esophageal pH monitoring (EpHm) according to new RI cut- off values; besides, correlate them with clinical diagnosis. Method: Retrospective study of EpHm parameters including RI, number and average length of episodes (DPE), number of episodes > 5 minutes and duration of the longest episode. 153 patients were classified according to age (Group I < 1 year and Group II > 1 year) and RI cut-off values: Normal group (NL) with physiological range (RI < 12% GI and < 6% GII) and Pathological group (PT) when RI was higher. Results: The most frequent EpHm indications were gastroesophageal reflux (GER) study (41.7%), airway diseases (19.9%) and otolaryngologic diseases (17.2%). There was no correlation between EpHm parameters in GI (n = 53) when analyzed by gender, referring physician or EpHm indication. In GII (n = 100), the RI for children referred by pediatricians was higher than the one for those referred by gastroenterologists in Group NL (p = 0.002). There were differences in all pH metric parameters according to NL and PT groups, except DPE. 84.9% and 77% of the EpHms in GI and GII respectively were normal. Conclusions: The EpHm parameters allow the division in NL and PT groups according to new RI cut-off values. There is a weak correlation between clinical suspicion and pHmetric diagnosis, sugesting the necessity to reevaluate EpHm indications
- Published
- 2007
23. Evaluación de los índices de monitoreo de pH esofágico y su relación con indicaciones clínicas: MePeache Fase I.
- Author
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G., Silvana Saavedra, M., Francisca Jaime, A., Juan Cristóbal Gana, B., Francisco Larraín, C., Ernesto Guiraldes, and D., Paul R. Harris
- Abstract
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- Published
- 2007
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