1. Methylphenidate modifies activity in the prefrontal and parietal cortex accelerating the time judgment
- Author
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Valécia Carvalho, Mauricio Cagy, Paulo Ramiler Alves da Silva, Victor Marinho, Kaline Rocha, Tiago Lopes Farias, Victor Hugo Bastos, Daya S. Gupta, Pedro Ribeiro, Fernando Lopes e Silva-Júnior, Bruna Velasques, Silmar Teixeira, Francisca Daniela Barros Silva, and Ariel Soares Teles
- Subjects
Adult ,Male ,Ventrolateral prefrontal cortex ,Prefrontal Cortex ,Posterior parietal cortex ,Dermatology ,Electroencephalography ,Judgment ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Double-Blind Method ,Parietal Lobe ,Reaction Time ,Humans ,Medicine ,030212 general & internal medicine ,Prefrontal cortex ,Cross-Over Studies ,medicine.diagnostic_test ,business.industry ,Methylphenidate ,Working memory ,General Medicine ,Executive functions ,Dorsolateral prefrontal cortex ,Alpha Rhythm ,Psychiatry and Mental health ,medicine.anatomical_structure ,Time Perception ,Central Nervous System Stimulants ,Neurology (clinical) ,business ,Neuroscience ,Psychomotor Performance ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Methylphenidate produces its effects via actions on cortical areas involved with attention and working memory, which have a direct role in time estimation judgment tasks. In particular, the prefrontal and parietal cortex has been the target of several studies to understand the effect of methylphenidate on executive functions and time interval perception. However, it has not yet been studied whether acute administration of methylphenidate influences performance in time estimation task and the changes in alpha band absolute power in the prefrontal and parietal cortex. The current study investigates the influence of the acute use of methylphenidate in both performance and judgment in the time estimation interpretation through the alpha band absolute power activity in the prefrontal and parietal cortex. This is a double-blind, crossover study with a sample of 32 subjects under control (placebo) and experimental (methylphenidate) conditions with absolute alpha band power analysis during a time estimation task. We observed that methylphenidate does not influence task performance (p > 0.05), but it increases the time interval underestimation by over 7 s (p
- Published
- 2019
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