1,728 results on '"Francis, Darrel P"'
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2. Catheter ablation improves cardiovascular outcomes in patients with atrial fibrillation and heart failure: a meta-analysis of randomized controlled trials.
- Author
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Simader, Florentina, Howard, James, Ahmad, Yousif, Saleh, Keenan, Naraen, Akriti, Samways, Jack, Mohal, Jagdeep, Reddy, Rohin, Kaza, Nandita, Keene, Daniel, Shun-Shin, Matthew, Francis, Darrel, Whinnett, Zachary, and Arnold, Ahran
- Subjects
Ablation ,Atrial fibrillation ,Heart failure ,Meta-analysis ,Pulmonary vein isolation ,Humans ,Atrial Fibrillation ,Anti-Arrhythmia Agents ,Randomized Controlled Trials as Topic ,Heart Failure ,Catheter Ablation ,Treatment Outcome - Abstract
AIMS: The effect of atrial fibrillation catheter ablation on cardiovascular outcomes in heart failure is an important outstanding research question. We undertook a meta-analysis of randomized controlled trials comparing ablation to medical therapy in patients with AF and heart failure. METHODS AND RESULTS: We systematically identified all trials comparing catheter ablation to medical therapy in patients with heart failure and atrial fibrillation. The pre-specified primary endpoint was all-cause mortality in trials with at least 2 years of follow-up. The secondary endpoint was heart failure hospitalization. Sensitivity analyses were performed for trials with any follow-up and trials deemed at low risk of bias. Eight trials (1390 patients) were included. Seven hundred and seven patients were randomized to catheter ablation and 683 to medical therapy. In the primary analysis (three trials, n = 977), catheter ablation reduced mortality compared with medical therapy [relative risk (RR): 0.61, 95% confidence interval (CI): 0.44 to 0.84, P = 0.003]. Catheter ablation also reduced heart failure hospitalizations compared with medical therapy (RR: 0.60, 95% CI: 0.49-0.74, P < 0.001). The effect on stroke was not statistically significant (RR: 0.62, 95% CI: 0.28-1.37, P = 0.237). There was low heterogeneity between studies. Sensitivity analyses were consistent with the primary analyses. CONCLUSION: In patients with atrial fibrillation and heart failure, catheter ablation reduces mortality and the occurrence of heart failure hospitalizations.
- Published
- 2023
3. Catheter Ablation for Ventricular Tachycardia After MI: A Reconstructed Individual Patient Data Meta-analysis of Randomised Controlled Trials.
- Author
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Reddy, Rohin, Howard, James, Ahmad, Yousif, Shun-Shin, Matthew, Simader, Florentina, Miyazawa, Alejandra, Saleh, Keenan, Naraen, Akriti, Samways, Jack, Katritsis, George, Mohal, Jagdeep, Kaza, Nandita, Porter, Bradley, Keene, Daniel, Linton, Nicholas, Francis, Darrel, Whinnett, Zachary, Luther, Vishal, Kanagaratnam, Prapa, and Arnold, Ahran
- Subjects
MI ,Ventricular tachycardia ,ablation ,meta-analysis - Abstract
BACKGROUND: The prognostic impact of ventricular tachycardia (VT) catheter ablation is an important outstanding research question. We undertook a reconstructed individual patient data meta-analysis of randomised controlled trials comparing ablation to medical therapy in patients developing VT after MI. METHODS: We systematically identified all trials comparing catheter ablation to medical therapy in patients with VT and prior MI. The prespecified primary endpoint was reconstructed individual patient assessment of all-cause mortality. Prespecified secondary endpoints included trial-level assessment of all-cause mortality, VT recurrence or defibrillator shocks and all-cause hospitalisations. Prespecified subgroup analysis was performed for ablation approaches involving only substrate modification without VT activation mapping. Sensitivity analyses were performed depending on the proportion of patients with prior MI included. RESULTS: Eight trials, recruiting a total of 874 patients, were included. Of these 874 patients, 430 were randomised to catheter ablation and 444 were randomised to medical therapy. Catheter ablation reduced all-cause mortality compared with medical therapy when synthesising individual patient data (HR 0.63; 95% CI [0.41-0.96]; p=0.03), but not in trial-level analysis (RR 0.91; 95% CI [0.67-1.23]; p=0.53; I2=0%). Catheter ablation significantly reduced VT recurrence, defibrillator shocks and hospitalisations compared with medical therapy. Sensitivity analyses were consistent with the primary analyses. CONCLUSION: In patients with postinfarct VT, catheter ablation reduces mortality.
- Published
- 2023
4. Long-term clinical outcomes and cost-effectiveness of catheter vs thoracoscopic surgical ablation in long-standing persistent atrial fibrillation using continuous cardiac monitoring: CASA-AF randomized controlled trial
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Yahdev, Rashmi, Rahman-Halley, Shelley, Wong, Joyce, Opel, Aaisha, Kaba, Riyaz, Nyktari, Eva, Cambronero-Cortinas, Esther, Izgi, Cemil, Fairbairn, Timothy, Benton, Joanne, Chester, Ruth, Cunliffe, Eliane, Edmondson, Lucy, Gill, Matthew, Griffiths, Vicky, Harman, Rebecca, Huggett, Catherine, Keegan, Jenny, Kirby, Kevin, Lascelles, Karen, Manivarmane, Ramasamy, Munteanu, Iulia, O’Brien, Karen, Phyl, Tess, Rahneva, Tsveta, Riley, Cheryl, Rogers, Paula, Smith, Katherine, Wage, Rick, West, Cathy, Yakupoglu, Yakup, Yang, Guang, Audraite, Audra, Belchambers, Sandra, Hughes, Susan, Morgan, Maureen, Ronayne, Christina, Shaw, Rob, Simkus, Paulinus, Taylerson, Clive, Bruce, Chloe, McGregor, Andrew, Thomson, Catherine, Granville, Hollie, Snell, Alice, John, Sophia, Monteiro, Christiana, Augustine, Grace, Sutton, Nichola, Boyalla, Vennela, Haldar, Shouvik, Khan, Habib, Kralj-Hans, Ines, Banya, Winston, Lord, Joanne, Satishkumar, Anitha, Bahrami, Toufan, De Souza, Anthony, Clague, Jonathan R., Francis, Darrel P., Hussain, Wajid, Jarman, Julian W., Jones, David G., Chen, Zhong, Mediratta, Neeraj, Hyde, Jonathan, Lewis, Michael, Mohiaddin, Raad, Salukhe, Tushar V., Markides, Vias, McCready, James, Gupta, Dhiraj, and Wong, Tom
- Published
- 2024
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5. Factors Associated With Coronary Angiography Performed Within 6 Months of Randomization to the Conservative Strategy in the ISCHEMIA Trial
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Pracoń, Radosław, Spertus, John A., Broderick, Samuel, Bangalore, Sripal, Rockhold, Frank W., Ruzyllo, Witold, Demchenko, Elena, Nageh, Thuraia, Grossman, Gabriel Blacher, Mavromatis, Kreton, Manjunath, Cholenahally N., Smanio, Paola E.P., Stone, Gregg W., Mancini, G.B. John, Boden, William E., Newman, Jonathan D., Reynolds, Harmony R., Hochman, Judith S., Maron, David J., Doan, John, Linefsky, Jason, Lee, Raven, Patel, Risha, Miller, Todd, Yang Cho, So, Milbrandt, Susan, Shelstad, Dawn, Banerjee, Subhash, Kamath, Preeti, Tejani, Ishita, Cobos, Stanley E., Quiles, Kirsten J., Dwyer, Raven R., Donnino, Robert M., Espinosa, Dalisa, Phillips, Lawrence M., Saric, Muhamed, Abdul-Nour, Khaled, Schley, Allison, Golden, Heather, Stone, Peter H., Osseni, Hermine, Wiyarand, Charlene, Douglass, Peter, Pomeroy, Hayley, Craft, Alexandra, Harvey, Bethany, Jang, James J., Anaya, Olivia, Yee, Gennie, Goold, Phoebe, Weitz, Steven, Giovannone, Steven, Pritchard, Lori, Arnold, Suzanne, Gans, Rosann, Henry O’Keefe, Jr, James, Kennedy, Paul, Shapiro, Michael D., Ganesan, Shobana, Schlichting, David, Naher, Aynun, El-Hajjar, Mohammad, Sidhu, Mandeep S., Fein, Steven A., Stewart, Wendy L., Torosoff, Mikhail T., Salmi, Kristin M., Lyubarova, Radmila, Mookherjee, Sulagna, Drzymalski, Krzysztof, McFalls, Edward O., Garcia, Santiago A., Bertog, Stefan C., Johnson, Debra K., Siddiqui, Rizwan A., Herrmann, Rebekah R., Ishani, Areef, Hansen, Ronnell A., Georges Khouri, Michel, Arges, Kristine, LeFevre, Melissa, Tomfohr, Jennifer, Goldberg, Jonathan L., Ann Byrne, Kimberly, Zappernick, Taissa, Goldweit, Richard, Canada, Sallie, Kakade, Meghana, Mieses, Patricia, Cobos, Stanley E., Dwyer, Raven R., Cohen, Ronny A., Espinosa, Dalisa, Mirrer, Brooks, Quiles, Kirsten J., Navarro, Victor, Rantinella, Magdalena, Rodriguez, Jessica, Mancilla, Olivia, Winchester, David E., Stinson, Susan, Kronenberg, Marvin, Weyand, Terry, Rogal, Philip, Crook, Sherron C., McFarren, Christopher, Heitner, John F., Ho, Jean, Khan, Saadat, Mohamed, Mahmoud, Dauber, Ira M., Soltau, Mary R., Rose, Delsa K., Wimmer, Rebecca J., Siegel, Kathy E., Derbyshire, Susan, Cannan, Charles, Dixon, Michelle, Leonard, Gerald, Sudarshan, Sriram, Heard, Ciarra, Gabriel, Viviana, Desire, Sukie, Mehta, Puja K., McDaniel, Michael, Rashid, Fauzia, Lerakis, Stamatios, Asier, Senait, Quyyumi, Arshed, Patel, Keyur, Wenger, Nanette K., Hedgepeth, Chester M., Gillis, Jennifer, Hurlburt, Heather, Manocchia, Megan, Rosen, Alan, Moore, Susan, Congdon, Elizabeth, Sahul, Zakir, Brandt, Gail, Marchelletta, Nora, Wippler, Kristina, Booth, David, Taul, Yvonne, Leung, Steve, Isaacs, Jennifer, Abdel-Latif, Ahmed, Bulkley, Viktoria, Reda, Hassan, Rodgers, Caroline, Ziada, Khaled, Setty, Sampoornima, Halverson, Kimberly E., Roraff, Christine, Thorsen, Jonean, Barua, Rajat S., Ojajuni, Amarachi, Olurinde, Oni, Surineni, Kamalakar, Hage, Fadi, Valaiyapathi, Badhma, Caldeira, Christiano, Davies, James E., Leesar, Massoud, Heo, Jaekyeong, Iskandrian, Amy, Al Solaiman, Firas, Singh, Satinder, Dajani, Khaled, Kartje, Carol M., El-Hajjar, Mohammad, Mesropian, Paul Der, Sacco, Joseph, Rawlins, Michele, McCandless, Brian, Thomson, Jennifer, Orgera, Marisa, Sidhu, Mandeep S., Colleen Rogge, Mary, Arif, Imran, Bunke, Julie, Kerr, Hanan, Unterbrink, Kendra, Fannon, Jacqueline, Burman, Cynthia, Trejo, Jorge F., Dubin, Marcia F., Fletcher, Gerald, Lane, Gary E., Neeson, Lynn M., Parikh, Pragnesh P., Pollak, Peter M., Shapiro, Brian P., Landolfo, Kevin, Gemignani, Anthony, Beaudry, Sarah, O’Rourke, Daniel, Meadows, Judith L., Tirado, Stephanie A., Halliday, Janet, Julian, Pamela, Call, Jason T., Lane, Stephanie M., Stanford, Jennifer L., Hannan, Joseph, Bojar, Robert, Arsenault, Patricia, Kumar, Deepti, Sigel, Pamela, Mukai, John, Martin, Edward T., Brooks, Miriam, Vorobiof, Gabriel, Douangvila, Ladda, Gevorgyan, Rubine, Moorman, Alec, Ranjbaran, Fatima, Smith, Bryn, Ohmart, Carly, Kinlay, Scott, Hamburger, Robert J., Rocco, Thomas P., Ly, Samantha, Bhatt, Deepak L., Quinn, Margot C., Croce, Kevin, Temiyasathit, Sara, Quin, Jacquelyn A, Do, Jacquelyn, Anumpa, Jati, Tobin, Desiree, Zenati, Marco, Faxon, David P, Rayos, Glenn, Langdon, Jennifer, Werner Bayer, Marcia, Seedhom, Ashraf, O’Malley, Amanda, Sullenberger, Lance, Orvis, Erin, Kumkumian, Gregory, Murphy, Mandy, Greenberg, Ann, Iraola, Margaret, Sedlis, Steven P., Maranan, Leandro C., Donnino, Robert M., Lorin, Jeffrey, Tamis-Holland, Jacqueline E., Malinay, Ammy, Kornberg, Robert, Leber, Robert, Saba, Souheil, Edillo, Candice P., Lee, Michael W., Small, Delano R., Nona, Wassim, Alexander, Patrick B., Rehman, Iram, Badami, Umesh, Ostrander, Ann, Wasmiller, Stephanie, Marzo, Kevin, Drewes, Wendy, Patel, Dipti, Robbins, Inga H., Levite, Howard A., White, Jackie M, Shetty, Sanjay, Hallam, Alison, Patel, Mayuri, Hamroff, Glenn S., Spooner, Benjamin J, Hollenweger, Linda M, Little, Raymond W., Little, Holly, Zimbelman, Brandi D., Little, Tiffany, Lui, Charles Y., Eskelson, Nona A, Smith, Brigham R., Vezina, Daniel P., Khor, Lillian L., Abraham, Josephine D., Bull, David A., McKellar, Stephen H., Booth, David, Taul, Yvonne, Kotter, John, Rodgers, Caroline, Abdel-Latif, Ahmed, Isaacs, Jennifer, Bulkley, Viktoria, Hu, Bob, Kaneshiro, Renee, Labovitz, Arthur J., Berlowitz, Michael, Kirby, Bonnie J., Rogal, Philip, Tran, Nhi N., McFarren, Christopher, Jahrsdorfer, Catherine, Matar, Fadi, Caldeira, Christiano, Rodriguez, Fatima, Yunis, Reem, Schnittger, Ingela, Patro, Jhina, Fearon, William F., Deedwania, Prakash, Vega, Antonia, Reddy, Kiran, Sweeny, Joseph, Bloise-Adames, Hugo, Jimenez, Santa, Saint Vrestil, Nicole, Bhandari, Reyna, Spizzieri, Christopher, Schade, Danielle, Yost, Roxanne, Hochberg, Claudia P, Beardsley, Paula, Fine, Denise, Salerno, William D., Tancredi, Jana, Arakelian, Patricia, Mathus, Susan, O’Neill, Deborah, Wyman, Ray, Burkhardt, Joy, Hosino, Suellen, Lubyanaya, Oksana A., Salas, Jose D., Zarka, Amer, Aguirre, Maria, Shah, Anil V., Dhawan, Manu, Parra, Diana, Tran, Tri, Haldis, Thomas, Weick, Catherine, Fowler-Lehman, Katie, Spitzer, Natalie, Riedberger, Casey, Weick, Catherine, Kohn, Jeffrey A., Cobos, Stanley E., Dwyer, Raven R., Espinosa, Dalisa, Quiles, Kirsten J., Girotra, Saket, Drum, Carrie, Miller-Cox, Kimberly, Ollinger, Amy, Almousalli, Omar, Capasso-Gulve, Elizabeth, Melanie Loehr, Alaine, Mosley, Marlowe, Krishnam, Mayil S., Heydari, Shirin, Milliken, Jeffrey C., Lundeen, Andrea M., Patel, Pranav M., Karanjah, Edgar, Seto, Arnold H., Marfori, Wanda C., Harley, Kevin T., Hernandez-Rangel, Eduardo, Gibson, Michael A., Singh, Pam, Allen, Byron J., Coram, Rita, Marie Webb, Anne, Fridell, Ellie, Wilson, Heidi, Thomas, Sabu, Kim, Angela, Schwartz, Ronald G, Wilmot, Patrick, Chen, Wei, El Shahawy, Mahfouz, Stevens, Ramona, Stafford, James, Black, Loriane, Abernethy, William B., Hull, Amber B., Lim, Olivia J., Tucker, Helen C., Putnam, Natasha C., Hall, Linda L., Cauthren, Tia, Tucker, Trish, Zurick, Andrew, Horton, Hollie, Orga, Jan, Meyer, Thomas M., White, Joyce R., Morford, Ronald G., Baumann, Cynthia, Rutkin, Bruce, Seeratan, Vidya, Bokhari, Sabahat, Jimenez, Magnolia, Sokol, Seth I., Schultz, Cidney, Meisner, Jay, Russo, Jeanne, Hamzeh, Ihab, Misra, Arunima, Huda, Zohra, Wall, Matthew, Boan, Araceli, Lenges De Rosen, Veronica, Alam, Mahboob, Turner, Michael C., Hinton, Christine R, Mulhearn, Thomas J., Good, Arnold P., Archer, Beth A., Dionne, Julia S., Allardyce, Cheryl A., Sikora, Lindsey N., Czerniak, Jennifer H., Mull, Jennifer A., Ferguson, Elizabeth, Laube, Frances, Shammas, Nicolas W., Shammas, Gail A, Christensen, Lori, Park, Holly, Chilton, Robert, Hecht, Joan, Nguyen, Patricia K., Vo, Davis, Hirsch, James, Jezior, Matthew, Bindeman, Jody, Salkind, Sara, Espinosa, Dalisa, Desimone, Lori-Ann, Gordon, Paul C., Felix-Stern, Lina, Crain, Thomas, Gomes, Jassira, Gordon, Catherine, Stenberg, Robert, Mann, Aimee, McCreary, Theresa, Pedalino, Ronald P., Cobos, Stanley E., Dwyer, Raven R., Espinosa, Dalisa, Quiles, Kirsten J., Wiesel, Joseph, Cobos, Stanley E., Dwyer, Raven R., Espinosa, Dalisa, Quiles, Kirsten J., Juang, George J., Gopaul, Candace, Hultberg, Karen, Huk, Tauqir, Hussain, Afshan, Al-Amoodi, Mohammed, Zambrano, Yesenia, Medina Rodriguez, Sarah, Milner, Trudie, Wohns, David, Mulder, Abbey, Van Oosterhout, Stacie, Lader, Ellis W., Meyer, Martha, Mumma, Michael, Clapp, Nancy L., Barrentine, Heather, Dharmarajan, Lekshmi, Jose, Jenne M., Cobos, Stanley E., Dwyer, Raven R., Espinosa, Dalisa, Quiles, Kirsten J., Manchery, Jenne, McGarvey Jr, Joseph F.X., McKinney, Vera, Schwarz, Linda, Downes, Thomas R., Kaczkowski, Scott M., Luckasen, Gary J., Jaskowiak, Adam J., Klitch, Joel, Cheong, Benjamin, Dees, Debra, Potluri, Srinivasa, Vasquez, Precilia, Mastouri, Ronald A., Breall, Jeffery A., Hannemann, Elise L., Revtyak, George E., Mae Foltz, Judy, Bazeley, Jonathan W., Li, Dayuan, DeRosa, Emily, Jorgenson, Beth, Riestenberg-Smith, Joyce, Giedd, Kenneth, Old, Wayne, Bariciano, Rebecca, Burt, Francis, Sokhon, Kozhaya, Waldron, Jessica, Mayon, Michelle, Gopal, Deepika, Valeti, Uma S., Ann Peichel, Gretchen, Kobashigawa, Jon, Starks, Brandy, Garcia, Lucilla, Thottam, Maria, Bhargava, Balram, Anand, Anjali, Chakanalil Govindan, Sajeev, Raj, Janitha, Gopalan Nair, Rajesh, Ravindran, Reshma, Rajalekshmi, VS, Nataraj, Nandita, Moorthy, Nagaraja, Nayak, Soundarya, Mylarappa, Mahevamma, Narayanappa, Suryaprakash, Pandit, Neeraj, Bajaj, Sheromani, Kumar Nath, Ranjit, Yadav, Vandana, Mishra, Girish, Dwivedi, S.K., Tewari, Roma, Narain, V.S., Mishra, Meenakshi, Chandra, Sharad, Patel, Shivali, Singh, Suman, Wander, Gurpreet S., Tandon, Rohit, Ralhan, Sarju, Kaur, Baljeet, Aslam, Naved, Gupta, Sonika, Goyal, Abhishek, Bhargava, Balram, Suvarna, Chandini, Karthikeyan, G., Ramakrishnan, S., Seth, Sandeep, Yadav, Rakesh, Singh, Sandeep, Roy, Ambuj, Parakh, Neeraj, Kumar Verma, Sunil, Narang, Rajiv, Mishra, Sundeep, Naik, Nitish, Sharma, Gautam, Kumar Choudhary, Shiv, Patel, Chetan, Gulati, Gurpreet, Sharma, Sanjeev, Bahl, V K, Mathew, Anoop, Mannekkattukudy Kurian, Binoy, Punnoose, Eapen, Avdhoot Gadkari, Milind, Rupesh Karwa, Sheetal, Gadage, Siddharth, Kolhe, Suvarna, Umesh Pillay, Tapan, Satheesh, Santhosh, Vindhya, R. J., Jain, Peeyush, Seth, Ashok, Singh Meharwal, Zile, Mathur, Atul, Verma, Atul, Kaul, Upendra, Bhatia, Mona, Sachdeva, Ankush, Indira Devi, Thounaojam, Jungla, Nungshi, Christopher, Johann, Manjula Rani, K., Menon, Rajeev, Sowjanya Reddy, M., Kumar, Nirmal, Preethi, K., Oomman, Abraham, sidh, Rinu R, Mao, Robert, Ramakrishnan, T., Solomon, Hilda, Francis, Rajesh, Naik, Sudhir, Vamshi, Priya P., Parveen Khan, Sajeeda, Christopher, Johann, Preethi, Kotiboinna, Kumar, Nirmal, Grant, Purvez, Hande, Shweta, Sonawane, Poonam, Kachru, Ranjan, Dubey, Abhishek, Rawat, Kavita, Kumar, Ajit, Ganapathi, Sanjay, K, Jayakumar, CP, Vineeth, Sivadasanpillai, Harikrishnan, Chacko, Manas, Sasidharan, Bijulal, Babu, Suresh, TR, Kapilamoorthy, Christopher, Johann, Reddy, Sowjanya, Polamuri, Praneeth, Rani, Manjula, Kaul, Upendra, Arambam, Priyadarshani, Singh, Bebek, Senior, Roxy, Fox, Keith AA, Young, Grace M., Carruthers, Kathryn, Senior, Roxy, Elghamaz, Ahmed, Gurunathan, Sothinathan, Karogiannis, Nikolaos, Young, Grace M., Shah, Benoy N, Kinsey, Christopher, Trimlett, Richard HJ, Kavalakkat, Raisa, Rubens, Michael B, Evans, Jo, Nicol, Edward D, Hassan, Ikraam, Mittal, Tarun K, Hampson, Reinette, Andreas Gamma, Reto, Williams, Sarah, Holland, Kim, Swan, Karen, de Belder, Mark A, Atkinson, Bev, Thambyrajah, Jeet, Kunhunny, Swapna, Davies, John R, Lindsay, Steven J., Atkinson, Craig, Kurian, John, Krannila, Carita, Jamil, Haqeel, Vinod, Manitha, Raheem, Osama, Hoye, Angela, Chaytor, Lisa, Cox, Leanne, Morrow, Julie, Rowe, Kay, Donnelly, Patrick, Kelly, Stephanie, Valecka, Bernardas, Regan, Susan, Turnbull, Dawn, Chauhan, Anoop, Fleming, Catherine, Ghosh, Arijit, Gratrix, Karen, Preston, Stephen, Barr, Craig, Cartwright, Anne, Alfakih, Khaled, Knighton, Abigail, Byrne, Jonathan, Martin, Katherine, Webb, Ian, Henriksen, Peter, Flint, Laura, Harrison, James, OKane, Peter, Lakeman, Nicki, Ljubez, Anja, de Silva, Ramesh, Conway, Dwayne S. G., Wright, Judith, Exley, Donna, Sirker, Alexander A, Andiapen, Mervyn, Richards, Amy J., Hoole, Stephen P, Wong, Lisa, Witherow, Fraser N., Munro, Melanie J., Johnston, Nicola, Harbinson, Mark, McEvoy, Michelle, Walsh, Simon, Brown, Caroline, Douglas, Hanna, Luckie, Matthew, Charles, Thabitha, Kolakaluri, Laurel, Phillips, Hannah, Sobolewska, Jolanta, Morby, Louise, Hallett, Karen, Corbett, Carolyn, Winstanley, Lynne, Jeetley, Paramjit, Smit, Angelique, Patel, Niket, Kotecha, Tushar, Travill, Christopher, Gent, Susan, Karimullah, Iqbal, Hussain, Nafisa, Al-Bustami, Mahmud, Braganza, Denise, Haines, Fiona, Taaffe, Joanne, Henderson, Robert, Burton, Jane, Pointon, Kate, Colton, Maria, Naik, Surendra, King, Rachel, Mathew, Thomas, Brown, Ammani, Docherty, Andrew, Berry, Colin, McCloy, Lisa, Collison, Damien, Robb, Kate, Roditi, Giles, Paterson, Craig, Crawford, Wenda, Kelly, Joanne, McGregor, Lorraine, Moriarty, Andrew J, Mackin, Anne, Glover, Jason D., Knight, Janet P, Pradhan, Jiwan, Mikhail, Ghada, Bose, Tuhina, Francis, Darrel P., Dzavik, Vladimir, Goodman, Shaun, Gosselin, Gilbert, Gosselin, Gilbert, Proietti, Anna, Brousseau, Myriam, Corfias, Magalie, Blaise, Patricia, Harvey, Luc, Diaz, Ariel, Rheault, Philippe, Barrero, Miguel, Gagné, Carl-Éric, Alarie, Patricia, Pépin-Dubois, Yanek, Arcand, Linda, Costa, Ricardo, Roy, Isabelle, Tung Sia, Ying, Montpetit, Estelle, Lemay, Catherine, Gisbert, Alejandro, Gervais, Pierre, Rheault, Alain, Drouin, Katia, Carl Phaneuf, Denis, Bergeron, Christine, Gosselin, Gilbert, Shelley, Christine, Masson, Christine, Garg, Pallav, Carr, Sandy, Bone, Catherine, Chow, Benjamin J.W., Moga, Ermina, Hessian, Renee C., Kourzenkova, Janetta, Beanlands, Rob S., Walter, Olga, Davies, Richard F., Bainey, Kevin R., Hogg, Norma, Welsh, Suzanne, Cheema, Asim N., Bagai, Akshay, Wald, Ron, Goodman, Shaun, Kushniriuk, Khrystyna, Joseph Graham, John, Hussain, Mohammed, Peterson, Mark, Bello, Olugbenga, Chow, Chi-Ming, Abramson, Beth, Nazir Cheema, Asim, Syed, Ishba, Hussain, Mohammed, Kushniriuk, Khrystyna, Cha, James, Otis, Judy, Otis, Rebecca, Howarth, Andrew G, Seib, Michelle M, Rivest, Sandra M, Sandonato, Rosa, Wong, Graham, Chow, Jackie, Starovoytov, Andrew, Uchida, Naomi, Meadows, Ngaire, Uxa, Amar, Asif, Nadia, Tavares, Suzana, Galiwango, Paul, Bozek, Bev, Kassam, Saleem, Shier, Maria, Mukherjee, Ashok, Larmand, Lori-Ann, Ricci, A. Joseph, Janmohamed, Amir, Hart, Brenda, Lam, Andy, Marucci, Jane, Tai, Sharon, Mehta, Shamir, Brons, Sonya, Beck, Chris, Wong, Glenda, Etherington, Krystal, Arumairajah, Thippeekaa, Udell, Jacob, Aprile, Maria, Karlsson, Sara, Webber, Susan, Généreux, Philippe, Mercure, Chantale, Hameed, Adnan, Aedy, Nancy, Daba, Ledjalem, Farquharson, Fran, Siddiqui, Anam, Carlos Carvalho, Antonio, Lopes, Renato D., Hueb, Whady, Emy Takiuti, Myrthes, Cury Rezende, Paulo, Eustáquio Ribeiro Silva, Expedito, Ciappina Hueb, Alexandre, Pizzol Caetano, Leonardo, Schaan de Quadros, Alexandre, Abdala Karam Kalil, Renato, Peixoto Deiro, Aline, Luiz da Costa Vieira, José, Manica Muller, Alice, Antonieta Pereira de Moraes, Maria, Píccaro de Oliveira, Pedro, Maria Ascoli, Bruna, Bridi, Leonardo, Zottis Poletti, Sílvia, Savaris, Simone, Vitola, João V, Cerci, Rodrigo J, Zier, Sandra S., Farias, Fabio R, Veiga Jr, Vilmar, Fernandes, Miguel M, Antonio Marin-Neto, José, Schmidt, André, de Oliveira Lima Filho, Moysés, Franca da Cunha, Diego, Mendes Oliveira, Ricardo, Reynaldo Abbud Chierice, João, Polanczyk, Carísi A., Rucatti, Guilherme G, Furtado, Mariana V., Igansi, Fernanda, Smidt, Luis F., Haeffner, Mauren P, Carlos Carvalho, Antonio, Almeida, Viviane, Pucci, Gustavo, Sanchez de Souza, Gabriela, Lyra, Flavio, Rabelo Alves Junior, Alvaro, Almeida, Mayana, dos Santos, Viviane, Dracoulakis, Marianna D. A., Oliveira, Natalia S, Lima, Rodolfo G. S. 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- 2024
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6. Sodium-glucose cotransporter 2 inhibitors in patients with heart failure: a systematic review and meta-analysis of randomized trials.
- Author
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Ahmad, Yousif, Madhavan, Mahesh, Stone, Gregg, Francis, Darrel, Makkar, Raj, Bhatt, Deepak, and Howard, James
- Subjects
Clinical trials ,Heart failure ,Meta-analysis ,Humans ,Heart Failure ,Randomized Controlled Trials as Topic ,Sodium-Glucose Transporter 2 Inhibitors ,Treatment Outcome - Abstract
AIMS: Sodium-glucose cotransporter 2 (SGLT-2) inhibitors have now been evaluated for the treatment of heart failure in several placebo-controlled randomized controlled trials (RCTs) across various ejection fraction ranges, but these trials were powered for composite outcomes rather than individual clinical endpoints. We therefore performed a meta-analysis to assess their safety and efficacy on all-cause mortality, cardiovascular mortality, and heart failure hospitalizations. METHODS AND RESULTS: We performed a prospectively registered random-effects meta-analysis of all RCTs comparing SGLT-2 inhibitors to placebo in patients with heart failure. The pre-specified primary endpoint was all-cause mortality. Secondary endpoints included cardiovascular mortality, heart failure hospitalizations, and the composite of cardiovascular mortality or heart failure hospitalization. Four trials with 15 684 patients were eligible. The SGLT-2 inhibitor tested was empagliflozin in two trials, dapagliflozin in one trial, and sotagliflozin in one trial. The weighted-mean follow-up was 20.0 months. The hazard ratio (HR) for all-cause mortality was 0.91, 95% confidence interval (CI) 0.82-1.01, P = 0.071. There was a 12% reduction in cardiovascular mortality (HR 0.88, 95% CI 0.79 to 0.97, P = 0.012), and a 30% reduction in heart failure hospitalization (HR 0.70, 95% CI 0.64 to 0.77, P
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- 2022
7. 2-Dimensional Echocardiographic Global Longitudinal Strain With Artificial Intelligence Using Open Data From a UK-Wide Collaborative
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Stowell, Catherine C., Howard, James P., Ng, Tiffany, Cole, Graham D., Bhattacharyya, Sanjeev, Sehmi, Jobanpreet, Alzetani, Maysaa, Demetrescu, Camelia D., Hartley, Adam, Singh, Amar, Ghosh, Arjun, Vimalesvaran, Kavitha, Mangion, Kenneth, Rajani, Ronak, Rana, Bushra S., Zolgharni, Massoud, Francis, Darrel P., and Shun-Shin, Matthew J.
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- 2024
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8. Symptoms as a Predictor of the Placebo-Controlled Efficacy of PCI in Stable Coronary Artery Disease
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Rajkumar, Christopher, Foley, Michael, Ahmed-Jushuf, Fiyyaz, Simader, Florentina, Ganesananthan, Sashiananthan, Wang, Danqi, Mohsin, Muhammad, Pathimagaraj, Rachel, Macierzanka, Krzysztof, Petraco, Ricardo, Khamis, Ramzi, Cole, Graham, Howard, James, Mayet, Jamil, Francis, Darrel, Kokhar, Arif, Gohar, Aisha, Lampadakis, Ioannis, Seligman, Henry, Kaura, Amit, Nijjer, Sukhjinder, Sen, Sayan, Ramrakha, Punit, Kaprielian, Raffi, Malik, Iqbal, Khan, Masood, Sethi, Amarjit, Foale, Rodney, Keeble, Thomas, Tang, Kare, Davies, John, Gamma, Reto, Clesham, Gerald, Dungu, Jason, Kabir, Alamgir, Nazri, Shah Mohd, O’Kane, Peter, Hinton, Jonathan, Din, Jehangir, Nowbar, Alexandra, Kotecha, Tushar, Haworth, Peter, Spratt, James, Williams, Rupert, Cosgrove, Claudia, Lim, Pitt, Routledge, Helen, Mughal, Lal, Trevelyan, Jasper, Sinha, Manas, Curzen, Nick, Wilkinson, James, Sirohi, Rohit, Calver, Alison, Rawlins, John, Jabbour, Richard, Ruparelia, Neil, Sehmi, Joban, Kinnaird, Tim, Abdul, Fairoz, Panoulas, Vasileios, Collier, David, Thornton, George, Sohaib, Afzal, Al-Lamee, Rasha K., Simader, Florentina A., Rajkumar, Christopher A., Foley, Michael J., Chotai, Shayna, Bual, Nina, Khokhar, Arif, Pathimagaraj, Rachel H., Davies, John R., Keeble, Tom R., O’Kane, Peter D., Spratt, James C., Nijjer, Sukhjinder S., Howard, James P., Harrell, Frank E., Jr., Francis, Darrel P., and Shun-Shin, Matthew J.
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- 2024
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9. N-of-1 Trial of Angina Verification Before Percutaneous Coronary Intervention
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Rajkumar, Christopher A., Foley, Michael J., Ahmed-Jushuf, Fiyyaz, Simader, Florentina A., Mohsin, Muhammad, Ganesananthan, Sashiananthan, Nowbar, Alexandra N., Chotai, Shayna, Sen, Sayan, Petraco, Ricardo, Nijjer, Sukhjinder S., Sehmi, Joban, Ruparelia, Neil, Dungu, Jason N., Kabir, Alamgir, Tang, Kare, Gamma, Reto, Davies, John R., Kotecha, Tushar, Cole, Graham D., Howard, James P., Keeble, Thomas R., Clesham, Gerald, O’Kane, Peter D., Harrell, Frank E., Jr, Francis, Darrel P., Shun-Shin, Matthew J., and Al-Lamee, Rasha K.
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- 2024
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10. Active learning for left ventricle segmentation in echocardiography
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Alajrami, Eman, Ng, Tiffany, Jevsikov, Jevgeni, Naidoo, Preshen, Fernandes, Patricia, Azarmehr, Neda, Dinmohammadi, Fateme, Shun-shin, Matthew J., Dadashi Serej, Nasim, Francis, Darrel P., and Zolgharni, Massoud
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- 2024
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11. Coronary sinus reducer for the treatment of refractory angina (ORBITA-COSMIC): a randomised, placebo-controlled trial
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Foley, Michael J, Rajkumar, Christopher A, Ahmed-Jushuf, Fiyyaz, Simader, Florentina A, Chotai, Shayna, Pathimagaraj, Rachel H, Mohsin, Muhammad, Salih, Ahmed, Wang, Danqi, Dixit, Prithvi, Davies, John R, Keeble, Tom R, Cosgrove, Claudia, Spratt, James C, O’Kane, Peter D, De Silva, Ranil, Hill, Jonathan M, Nijjer, Sukhjinder S, Sen, Sayan, Petraco, Ricardo, Mikhail, Ghada W, Khamis, Ramzi, Kotecha, Tushar, Harrell, Frank E, Kellman, Peter, Francis, Darrel P, Howard, James P, Cole, Graham D, Shun-Shin, Matthew J, and Al-Lamee, Rasha K
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- 2024
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12. Automated mitral inflow Doppler peak velocity measurement using deep learning
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Jevsikov, Jevgeni, Ng, Tiffany, Lane, Elisabeth S., Alajrami, Eman, Naidoo, Preshen, Fernandes, Patricia, Sehmi, Joban S., Alzetani, Maysaa, Demetrescu, Camelia D., Azarmehr, Neda, Serej, Nasim Dadashi, Stowell, Catherine C., Shun-Shin, Matthew J., Francis, Darrel P., and Zolgharni, Massoud
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- 2024
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13. Automated Analysis of Mitral Inflow Doppler Using Deep Neural Networks
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Jevsikov, Jevgeni, Lane, Elisabeth S., Alajrami, Eman, Naidoo, Preshen, Serej, Nasim Dadashi, Azarmehr, Neda, Aleshaiker, Sama, Stowell, Catherine C., Shun-shin, Matthew J., Francis, Darrel P., Zolgharni, Massoud, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Bernard, Olivier, editor, Clarysse, Patrick, editor, Duchateau, Nicolas, editor, Ohayon, Jacques, editor, and Viallon, Magalie, editor
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- 2023
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14. Deep Active Learning for Left Ventricle Segmentation in Echocardiography
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Alajrami, Eman, Naidoo, Preshen, Jevsikov, Jevgeni, Lane, Elisabeth, Pordoy, Jamie, Serej, Nasim Dadashi, Azarmehr, Neda, Dinmohammadi, Fateme, Shun-shin, Matthew J., Francis, Darrel P., Zolgharni, Massoud, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Bernard, Olivier, editor, Clarysse, Patrick, editor, Duchateau, Nicolas, editor, Ohayon, Jacques, editor, and Viallon, Magalie, editor
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- 2023
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15. The ability of contemporary cardiologists to judge the ischemic impact of a coronary lesion visually
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Foley, Michael, Rajkumar, Christopher A., Ahmed-Jushuf, Fiyyaz, Nour, Daniel, Fung, Chi Ho, Seligman, Henry, Pathimagaraj, Rachel H., Petraco, Ricardo, Sen, Sayan, Nijjer, Sukhjinder, Howard, James P., Ahmad, Yousif, Allahwala, Usaid, Bhindi, Ravinay, Chamie, Daniel, Doi, Shunich, Kuwata, Shingo, Kaihara, Toshiki, Koga, Masashi, Ishibashi, Yuki, Higuma, Takumi, Tanabe, Yasuhiro, Nakayama, Masafumi, Kawase, Yoshiaki, Watanabe, Akifumi, Funayama, Naohiro, Horinaka, Ryo, Hijikata, Nobuhiro, Takahashi, Takamichi, Matsuo, Hitoshi, Hansen, Peter S., Manica, Andre, Weaver, James, Alzuhairi, Karam, Yong, Thon-Hon, Warisawa, Takayuki, Francis, Darrel P., Shun-Shin, Matthew J., and Al-Lamee, Rasha K.
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- 2024
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16. Quality assurance of late gadolinium enhancement cardiac magnetic resonance images: a deep learning classifier for confidence in the presence or absence of abnormality with potential to prompt real-time image optimization
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Zaman, Sameer, Vimalesvaran, Kavitha, Chappell, Digby, Varela, Marta, Peters, Nicholas S., Shiwani, Hunain, Knott, Kristopher D., Davies, Rhodri H., Moon, James C., Bharath, Anil A., Linton, Nick WF, Francis, Darrel P., Cole, Graham D., and Howard, James P.
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- 2024
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17. Automated multi-beat tissue Doppler echocardiography analysis using deep neural networks
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Lane, Elisabeth S., Jevsikov, Jevgeni, Shun-shin, Matthew J., Dhutia, Niti, Matoorian, Nasser, Cole, Graham D., Francis, Darrel P., and Zolgharni, Massoud
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- 2023
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18. Automated Segmentation of Left Ventricle in 2D echocardiography using deep learning
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Azarmehr, Neda, Ye, Xujiong, Janan, Faraz, Howard, James P, Francis, Darrel P, and Zolgharni, Massoud
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Electrical Engineering and Systems Science - Image and Video Processing - Abstract
Following the successful application of the U-Net to medical images, there have been different encoder-decoder models proposed as an improvement to the original U-Net for segmenting echocardiographic images. This study aims to examine the performance of the state-of-the-art proposed models as well as the original U-Net model by applying them to segment the endocardium of the Left Ventricle in 2D automatically. The prediction outputs of the models are used to evaluate the performance of the models by comparing the automated results against the expert annotations (gold standard). Our results reveal that the U-Net model outperforms other models by achieving an average Dice coefficient of 0.92$ \pm 0.05$, and Hausdorff distance of 3.97$ \pm 0.82$., Comment: 4 pages, 1 figure, Extended Abstract MIDL conference
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- 2020
19. A randomized controlled trial to investigate the use of acute coronary syndrome therapy in patients hospitalized with COVID-19: the COVID-19 Acute Coronary Syndrome trial
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Kanagaratnam, Prapa, Francis, Darrel P., Chamie, Daniel, Coyle, Clare, Marynina, Alena, Katritsis, George, Paiva, Patricia, Szigeti, Matyas, Cole, Graham, de Andrade Nunes, David, Howard, James, Esper, Rodrigo, Khan, Masood, More, Ranjit, Barreto, Guilherme, Meneguz-Moreno, Rafael, Arnold, Ahran, Nowbar, Alexandra, Kaura, Amit, Mariveles, Myril, March, Katherine, Shah, Jaymin, Nijjer, Sukhjinder, Lip, Gregory Y.H., Mills, Nicholas, Camm, A. John, Cooke, Graham S., Corbett, Simon J., Llewelyn, Martin J., Ghanima, Waleed, Toshner, Mark, Peters, Nicholas, Petraco, Ricardo, Al-Lamee, Rasha, Boshoff, Ana Sousa Marcelino, Durkina, Margarita, Malik, Iqbal, Ruparelia, Neil, Cornelius, Victoria, and Shun-Shin, Matthew
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- 2023
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20. Mortality after drug-eluting stents vs. coronary artery bypass grafting for left main coronary artery disease: a meta-analysis of randomized controlled trials.
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Ahmad, Yousif, Howard, James, Arnold, Ahran, Cook, Christopher, Prasad, Megha, Ali, Ziad, Parikh, Manish, Kosmidou, Ioanna, Francis, Darrel, Moses, Jeffrey, Leon, Martin, Kirtane, Ajay, Stone, Gregg, and Karmpaliotis, Dimitri
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CABG ,Left main stem ,PCI ,Coronary Artery Bypass ,Coronary Artery Disease ,Drug-Eluting Stents ,Humans ,Percutaneous Coronary Intervention ,Randomized Controlled Trials as Topic ,Treatment Outcome - Abstract
AIMS: The optimal method of revascularization for patients with left main coronary artery disease (LMCAD) is controversial. Coronary artery bypass graft surgery (CABG) has traditionally been considered the gold standard therapy, and recent randomized trials comparing CABG with percutaneous coronary intervention (PCI) with drug-eluting stents (DES) have reported conflicting outcomes. We, therefore, performed a systematic review and updated meta-analysis comparing CABG to PCI with DES for the treatment of LMCAD. METHODS AND RESULTS: We systematically identified all randomized trials comparing PCI with DES vs. CABG in patients with LMCAD. The primary efficacy endpoint was all-cause mortality. Secondary endpoints included cardiac death, myocardial infarction (MI), stroke, and unplanned revascularization. All analyses were by intention-to-treat. There were five eligible trials in which 4612 patients were randomized. The weighted mean follow-up duration was 67.1 months. There were no significant differences between PCI and CABG for the risk of all-cause mortality [relative risk (RR) 1.03, 95% confidence interval (CI) 0.81-1.32; P = 0.779] or cardiac death (RR 1.03, 95% CI 0.79-1.34; P = 0.817). There were also no significant differences in the risk of stroke (RR 0.74, 95% CI 0.35-1.50; P = 0.400) or MI (RR 1.22, 95% CI 0.96-1.56; P = 0.110). Percutaneous coronary intervention was associated with an increased risk of unplanned revascularization (RR 1.73, 95% CI 1.49-2.02; P
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- 2020
21. Complete Revascularization by Percutaneous Coronary Intervention for Patients With ST-Segment-Elevation Myocardial Infarction and Multivessel Coronary Artery Disease: An Updated Meta-Analysis of Randomized Trials.
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Ahmad, Yousif, Howard, James, Arnold, Ahran, Prasad, Megha, Seligman, Henry, Cook, Christopher, Warisawa, Takayuki, Shun-Shun, Matthew, Ali, Ziad, Parikh, Manish, Al-Lamee, Rasha, Sen, Sayan, Francis, Darrel, Moses, Jeffrey, Leon, Martin, Stone, Gregg, and Karmpaliotis, Dimitri
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ST‐segment–elevation myocardial infarction ,percutaneous coronary intervention ,revascularization ,Adult ,Aged ,Aged ,80 and over ,Coronary Artery Disease ,Female ,Humans ,Male ,Middle Aged ,Percutaneous Coronary Intervention ,Randomized Controlled Trials as Topic ,Recurrence ,Risk Assessment ,Risk Factors ,ST Elevation Myocardial Infarction ,Time Factors ,Treatment Outcome - Abstract
Background For patients with ST-segment-elevation myocardial infarction (STEMI) and multivessel coronary artery disease, the optimal treatment of the non-infarct-related artery has been controversial. This up-to-date meta-analysis focusing on individual clinical end points was performed to further evaluate the benefit of complete revascularization with percutaneous coronary intervention for patients with STEMI and multivessel coronary artery disease. Methods and Results We systematically identified all randomized trials comparing complete revascularization with percutaneous coronary intervention to culprit-only revascularization for multivessel disease in STEMI and performed a random-effects meta-analysis. The primary efficacy end point was cardiovascular death analyzed on an intention-to-treat basis. Secondary end points included all-cause mortality, myocardial infarction, and unplanned revascularization. Ten studies (7542 patients) were included: 3664 patients were randomized to complete revascularization and 3878 to culprit-only revascularization. Across all patients, complete revascularization was superior to culprit-only revascularization for reduction in the risk of cardiovascular death (relative risk [RR], 0.68; 95% CI, 0.47-0.98; P=0.037; I2=21.8%) and reduction in the risk of myocardial infarction (RR, 0.65; 95% CI, 0.54-0.79; P
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- 2020
22. Quality of Life Assessment in Trials of Revascularization for Chronic Stable Angina: Insights from ORBITA and the Implications of Blinding
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Nowbar, Alexandra N, Francis, Darrel P, and Al-Lamee, Rasha K
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- 2022
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23. Contributions of event rates, pre-hospital deaths, and deaths following hospitalisation to variations in myocardial infarction mortality in 326 districts in England: a spatial analysis of linked hospitalisation and mortality data
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Asaria, Perviz, Bennett, James E, Elliott, Paul, Rashid, Theo, Iyathooray Daby, Hima, Douglass, Margaret, Francis, Darrel P, Fecht, Daniela, and Ezzati, Majid
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- 2022
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24. Basic Principles of Hemodynamics in Pacing
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Miyazawa, Alejandra A., Francis, Darrel P., and Whinnett, Zachary I.
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- 2022
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25. Long-term clinical outcomes and cost-effectiveness of catheter vs thoracoscopic surgical ablation in long-standing persistent atrial fibrillation using continuous cardiac monitoring: CASA-AF randomized controlled trial.
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Boyalla, Vennela, Haldar, Shouvik, Khan, Habib, Kralj-Hans, Ines, Banya, Winston, Lord, Joanne, Satishkumar, Anitha, Bahrami, Toufan, De Souza, Anthony, Clague, Jonathan R., Francis, Darrel P., Hussain, Wajid, Jarman, Julian W., Jones, David G., Chen, Zhong, Mediratta, Neeraj, Hyde, Jonathan, Lewis, Michael, Mohiaddin, Raad, and Salukhe, Tushar V.
- Abstract
Long-term clinical outcomes of catheter ablation (CA) compared to thoracoscopic surgical ablation (SA) to treat patients with long-standing persistent atrial fibrillation (LSPAF) are not known. The purpose of this study was to compare the long-term (36-month) clinical efficacy, quality of life, and cost-effectiveness of SA and CA in LSPAF. Participants were followed up for 3 years using implantable loop recorders and questionnaires to assess the change in quality of life. Intention-to-treat analyses were used to report the findings. Of the 115 patients with LSPAF treated, 104 (90.4%) completed 36-month follow-up [CA: n = 57 (95%); SA: n = 47 (85%)]. After a single procedure without antiarrhythmic drugs, 7 patients (12%) in the CA arm and 5 (11%) in the SA arm [hazard ratio 1.22; 95% confidence interval (CI) 0.81–1.83; P =.41] were free from atrial fibrillation/tachycardia (AF/AT) ≥30 seconds at 36 months. Thirty-three patients (58%) in the CA arm and 26 (55%) in the SA arm (hazard ratio 1.04; 95% CI 0.57–1.88; P =.91) had their AF/AT burden reduced by ≥75%. The overall impact on health-related quality of life was similar, with mean quality-adjusted life year estimates of 2.45 (95% CI 2.31–2.59) for CA and 2.32 (95% CI 2.13–2.52) for SA. Estimated costs were higher for SA (mean £24,682; 95% CI £21,746–£27,618) than for CA (mean £18,002; 95% CI £15,422–£20,581). In symptomatic LSPAF, CA and SA were equally effective at achieving arrhythmia outcomes (freedom from AF/AT ≥30 seconds and ≥75% burden reduction) after a single procedure without antiarrhythmic drugs. However, SA is significantly more costly than CA. [ABSTRACT FROM AUTHOR]
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- 2024
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26. The Placebo Effect on Symptoms, Quality of Life, and Functional Outcomes in Patients With Angina Pectoris: A Meta-analysis of Randomized Placebo-Controlled Trials
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Gallone, Guglielmo, Baldetti, Luca, Angelini, Filippo, Saglietto, Andrea, Bellettini, Matteo, Beneduce, Alessandro, Ranotti, Viola, Chiarito, Mauro, Leone, Pier Pasquale, Pagnesi, Matteo, De Filippo, Ovidio, Landra, Federico, Bruno, Francesco, Marengo, Giorgio, Collino, Massimo, Ferrante, Giuseppe, Stefanini, Giulio G., Colombo, Antonio, Al-Lamee, Rasha, Francis, Darrel P., Jolicoeur, Marc E., Henry, Timothy D., Giannini, Francesco, D'Ascenzo, Fabrizio, and De Ferrari, Gaetano Maria
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- 2022
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27. Symptoms as a Predictor of the Placebo-Controlled Efficacy of PCI in Stable Coronary Artery Disease
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Simader, Florentina A., primary, Rajkumar, Christopher A., additional, Foley, Michael J., additional, Ahmed-Jushuf, Fiyyaz, additional, Chotai, Shayna, additional, Bual, Nina, additional, Khokhar, Arif, additional, Gohar, Aisha, additional, Lampadakis, Ioannis, additional, Ganesananthan, Sashiananthan, additional, Pathimagaraj, Rachel H., additional, Nowbar, Alexandra, additional, Davies, John R., additional, Keeble, Tom R., additional, O’Kane, Peter D., additional, Haworth, Peter, additional, Routledge, Helen, additional, Kotecha, Tushar, additional, Spratt, James C., additional, Williams, Rupert, additional, Nijjer, Sukhjinder S., additional, Sen, Sayan, additional, Curzen, Nick, additional, Sinha, Manas, additional, Howard, James P., additional, Cole, Graham, additional, Harrell, Frank E., additional, Francis, Darrel P., additional, Shun-Shin, Matthew J., additional, and Al-Lamee, Rasha K., additional
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- 2024
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28. Placebo Control and Blinding in Randomized Trials of Procedural Interventions
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Rajkumar, Christopher A., primary, Thomas, Katharine E., additional, Foley, Michael, additional, Ganesananthan, Sashiananthan, additional, Evans, Holli, additional, Simader, Florentina, additional, Syam, Sharan, additional, Nour, Daniel, additional, Beattie, Catherine, additional, Khan, Caitlin, additional, Reddy, Rohin K., additional, Ahmed-Jushuf, Fiyyaz, additional, Francis, Darrel P., additional, Shun-Shin, Matthew, additional, and Al-Lamee, Rasha K., additional
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- 2024
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29. Segmentation of Left Ventricle in 2D Echocardiography Using Deep Learning
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Azarmehr, Neda, Ye, Xujiong, Sacchi, Stefania, Howard, James P., Francis, Darrel P., Zolgharni, Massoud, Barbosa, Simone Diniz Junqueira, Editorial Board Member, Filipe, Joaquim, Editorial Board Member, Ghosh, Ashish, Editorial Board Member, Kotenko, Igor, Editorial Board Member, Zhou, Lizhu, Editorial Board Member, Zheng, Yalin, editor, Williams, Bryan M., editor, and Chen, Ke, editor
- Published
- 2020
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30. Left ventricular activation time and pattern are preserved with both selective and nonselective His bundle pacing
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Arnold, Ahran D., Shun-Shin, Matthew J., Ali, Nadine, Keene, Daniel, Howard, James P., Chow, Ji-Jian, Qureshi, Norman A., Koa-Wing, Michael, Tanner, Mark, Lefroy, David C., Linton, Nick W.F., Ng, Fu Siong, Lim, Phang Boon, Peters, Nicholas S., Kanagaratnam, Prapa, Francis, Darrel P., and Whinnett, Zachary I.
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- 2021
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31. Side Effect Patterns in a Crossover Trial of Statin, Placebo, and No Treatment
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Howard, James P., Wood, Frances A., Finegold, Judith A., Nowbar, Alexandra N., Thompson, David M., Arnold, Ahran D., Rajkumar, Christopher A., Connolly, Susan, Cegla, Jaimini, Stride, Chris, Sever, Peter, Norton, Christine, Thom, Simon A.M., Shun-Shin, Matthew J., and Francis, Darrel P.
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- 2021
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32. Multibeat echocardiographic phase detection using deep neural networks
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Lane, Elisabeth S., Azarmehr, Neda, Jevsikov, Jevgeni, Howard, James P., Shun-shin, Matthew J., Cole, Graham D., Francis, Darrel P., and Zolgharni, Massoud
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- 2021
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33. Resonance as the Mechanism of Daytime Periodic Breathing in Patients with Heart Failure
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Sands, Scott A, Mebrate, Yoseph, Edwards, Bradley A, Nemati, Shamim, Manisty, Charlotte H, Desai, Akshay S, Wellman, Andrew, Willson, Keith, Francis, Darrel P, Butler, James P, and Malhotra, Atul
- Subjects
Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Heart Disease ,Clinical Research ,Cardiovascular ,2.1 Biological and endogenous factors ,Aetiology ,1.1 Normal biological development and functioning ,Underpinning research ,Carbon Dioxide ,Case-Control Studies ,Cheyne-Stokes Respiration ,Circadian Rhythm ,Female ,Heart Failure ,Humans ,Male ,Middle Aged ,Respiratory Rate ,Cheyne-Stokes respiration ,chemosensitivity ,heart failure ,instability ,loop gain ,Medical and Health Sciences ,Respiratory System ,Cardiovascular medicine and haematology ,Clinical sciences - Abstract
RationaleIn patients with chronic heart failure, daytime oscillatory breathing at rest is associated with a high risk of mortality. Experimental evidence, including exaggerated ventilatory responses to CO2 and prolonged circulation time, implicates the ventilatory control system and suggests feedback instability (loop gain > 1) is responsible. However, daytime oscillatory patterns often appear remarkably irregular versus classic instability (Cheyne-Stokes respiration), suggesting our mechanistic understanding is limited.ObjectivesWe propose that daytime ventilatory oscillations generally result from a chemoreflex resonance, in which spontaneous biological variations in ventilatory drive repeatedly induce temporary and irregular ringing effects. Importantly, the ease with which spontaneous biological variations induce irregular oscillations (resonance "strength") rises profoundly as loop gain rises toward 1. We tested this hypothesis through a comparison of mathematical predictions against actual measurements in patients with heart failure and healthy control subjects.MethodsIn 25 patients with chronic heart failure and 25 control subjects, we examined spontaneous oscillations in ventilation and separately quantified loop gain using dynamic inspired CO2 stimulation.Measurements and main resultsResonance was detected in 24 of 25 patients with heart failure and 18 of 25 control subjects. With increased loop gain-consequent to increased chemosensitivity and delay-the strength of spontaneous oscillations increased precipitously as predicted (r = 0.88), yielding larger (r = 0.78) and more regular (interpeak interval SD, r = -0.68) oscillations (P
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- 2017
34. Automated analysis and detection of abnormalities in transaxial anatomical cardiovascular magnetic resonance images: a proof of concept study with potential to optimize image acquisition
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Howard, James P., Zaman, Sameer, Ragavan, Aaraby, Hall, Kerry, Leonard, Greg, Sutanto, Sharon, Ramadoss, Vijay, Razvi, Yousuf, Linton, Nick F., Bharath, Anil, Shun-Shin, Matthew, Rueckert, Daniel, Francis, Darrel, and Cole, Graham
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- 2021
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35. The arrhythmic substrate of hypertrophic cardiomyopathy using ECG imaging.
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Ji-Jian Chow, Leong, Kevin M. W., Shun-Shin, Matthew, Jones, Sian, Guttmann, Oliver P., Mohiddin, Saidi A., Lambiase, Pier, Elliott, Perry M., Ormerod, Julian O. M., Koa-Wing, Michael, Lefroy, David, Phang Boon Lim, Linton, Nicholas W. F., Fu Siong Ng, Qureshi, Norman A., Whinnett, Zachary I., Peters, Nicholas S., Francis, Darrel P., Varnava, Amanda M., and Kanagaratnam, Prapa
- Subjects
VENTRICULAR arrhythmia ,VENTRICULAR fibrillation ,HYPERTROPHIC cardiomyopathy ,VENTRICULAR tachycardia ,IMPLANTABLE cardioverter-defibrillators - Abstract
Introduction: Patients with hypertrophic cardiomyopathy (HCM) are at risk for lethal ventricular arrhythmia, but the electrophysiological substrate behind this is not well-understood. We used non-invasive electrocardiographic imaging to characterize patients with HCM, including cardiac arrest survivors. Methods: HCM patients surviving ventricular fibrillation or hemodynamically unstable ventricular tachycardia (n = 17) were compared to HCM patients without a personal history of potentially lethal arrhythmia (n = 20) and a pooled control group with structurally normal hearts. Subjects underwent exercise testing by non-invasive electrocardiographic imaging to estimate epicardial electrophysiology. Results: Visual inspection of reconstructed epicardial HCM maps revealed isolated patches of late activation time (AT), prolonged activation-recovery intervals (ARIs), as well as reversal of apico-basal trends in T-wave inversion and ARI compared to controls (p < 0.005 for all). AT and ARI were compared between groups. The pooled HCM group had longer mean AT (60.1 ms vs. 52.2 ms, p < 0.001), activation dispersion (55.2 ms vs. 48.6 ms, p = 0.026), and mean ARI (227 ms vs. 217 ms, p = 0.016) than structurally normal heart controls. HCM ventricular arrhythmia survivors could be differentiated from HCM patients without a personal history of life-threatening arrhythmia by longer mean AT (63.2 ms vs. 57.4 ms, p = 0.007), steeper activation gradients (0.45 ms/mm vs. 0.36 ms/mm, p = 0.011), and longer mean ARI (234.0 ms vs. 221.4 ms, p = 0.026). A logistic regression model including whole heart mean activation time and activation recovery interval could identify ventricular arrhythmia survivors from the HCM cohort, producing a C statistic of 0.76 (95% confidence interval 0.72-0.81), with an optimal sensitivity of 78.6% and a specificity of 79.8%. Discussion: The HCM epicardial electrotype is characterized by delayed, dispersed conduction and prolonged, dispersed activation-recovery intervals. Combination of electrophysiologic measures with logistic regression can improve differentiation over single variables. Future studies could test such models prospectively for risk stratification of sudden death due to HCM. [ABSTRACT FROM AUTHOR]
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- 2024
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36. Therapeutic options for neurocardiogenic syncope: a meta-analysis of randomised trials with and without blinding.
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Kaza, Nandita, Sorbini, Michela, Liu, Zhuang, Johal, Monika, Porter, Bradley, Nowbar, Alexandra, Levy, Shuli, Dani, Melanie, Taraborelli, Patricia, Eardley, Philip, Zuhair, Mohamed, Arnold, Ahran, Howard, James, Whinnett, Zachary I., Francis, Darrel P., Shun-Shin, Matthew J., Lim, Phang Boon, and Keene, Daniel
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- 2024
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37. Safety of Revascularization Deferral of Left Main Stenosis Based on Instantaneous Wave-Free Ratio Evaluation
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Warisawa, Takayuki, Cook, Christopher M., Rajkumar, Christopher, Howard, James P., Seligman, Henry, Ahmad, Yousif, El Hajj, Stephanie, Doi, Shunichi, Nakajima, Akihiro, Nakayama, Masafumi, Goto, Sonoka, Vera-Urquiza, Rafael, Sato, Takao, Kikuta, Yuetsu, Kawase, Yoshiaki, Nishina, Hidetaka, Petraco, Ricardo, Al-Lamee, Rasha, Nijjer, Sukhjinder, Sen, Sayan, Nakamura, Sunao, Lerman, Amir, Matsuo, Hitoshi, Francis, Darrel P., Akashi, Yoshihiro J., Escaned, Javier, and Davies, Justin E.
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- 2020
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38. Discriminating electrocardiographic responses to His-bundle pacing using machine learning
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Arnold, Ahran D., Howard, James P., Gopi, Aiswarya, Chan, Cheng Pou, Ali, Nadine, Keene, Daniel, Shun-Shin, Matthew J., Ahmad, Yousif, Wright, Ian J., Ng, Fu Siong, Linton, Nick W.F., Kanagaratnam, Prapa, Peters, Nicholas S., Rueckert, Daniel, Francis, Darrel P., and Whinnett, Zachary I.
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- 2020
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39. Sex Differences in Revascularization, Treatment Goals, and Outcomes of Patients With Chronic Coronary Disease: Insights From the ISCHEMIA Trial
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Reynolds, Harmony R., primary, Cyr, Derek D., additional, Merz, C. Noel Bairey, additional, Shaw, Leslee J., additional, Chaitman, Bernard R., additional, Boden, William E., additional, Alexander, Karen P., additional, Rosenberg, Yves D., additional, Bangalore, Sripal, additional, Stone, Gregg W., additional, Held, Claes, additional, Spertus, John, additional, Goetschalckx, Kaatje, additional, Bockeria, Olga, additional, Newman, Jonathan D., additional, Berger, Jeffrey S., additional, Elghamaz, Ahmed, additional, Lopes, Renato D., additional, Min, James K., additional, Berman, Daniel S., additional, Picard, Michael H., additional, Kwong, Raymond Y., additional, Harrington, Robert A., additional, Thomas, Boban, additional, O'Brien, Sean M., additional, Maron, David J., additional, Hochman, Judith S., additional, Mavromatis, Kreton, additional, Linefsky, Jason, additional, Miller, Todd, additional, Banerjee, Subhash, additional, Reynolds, Harmony R., additional, Donnino, Robert M., additional, Phillips, Lawrence M., additional, Saric, Muhamed, additional, Abdul‐Nour, Khaled, additional, Stone, Peter H., additional, Jang, James J., additional, Yee, Gennie, additional, Weitz, Steven, additional, Arnold, Suzanne, additional, O’Keefe, James Henry, additional, Shapiro, Michael D., additional, El‐Hajjar, Mohammad, additional, Sidhu, Mandeep S., additional, Fein, Steven A., additional, Torosoff, Mikhail T., additional, Lyubarova, Radmila, additional, Mookherjee, Sulagna, additional, Drzymalski, Krzysztof, additional, McFalls, Edward O., additional, Garcia, Santiago A., additional, Bertog, Stefan C., additional, Siddiqui, Rizwan A., additional, Ishani, Areef, additional, Hansen, Ronnell A., additional, Khouri, Michel Georges, additional, Goldberg, Jonathan L., additional, Goldweit, Richard, additional, Cohen, Ronny A., additional, Mirrer, Brooks, additional, Navarro, Victor, additional, Winchester, David E., additional, Kronenberg, Marvin, additional, Rogal, Philip, additional, McFarren, Christopher, additional, Heitner, John F., additional, Dauber, Ira M., additional, Cannan, Charles, additional, Sudarshan, Sriram, additional, Mehta, Puja K., additional, McDaniel, Michael, additional, Lerakis, Stamatios, additional, Quyyumi, Arshed, additional, Wenger, Nanette K., additional, Hedgepeth, Chester M., additional, Hurlburt, Heather, additional, Rosen, Alan, additional, Sahul, Zakir, additional, Booth, David, additional, Leung, Steve, additional, Abdel‐Latif, Ahmed, additional, Reda, Hassan, additional, Ziada, Khaled, additional, Setty, Sampoornima, additional, Barua, Rajat S., additional, Hage, Fadi, additional, Caldeira, Christiano, additional, Davies, James E., additional, Leesar, Massoud, additional, Heo, Jaekyeong, additional, Iskandrian, Amy, additional, Al Solaiman, Firas, additional, Singh, Satinder, additional, Dajani, Khaled, additional, Der Mesropian, Paul, additional, Sacco, Joseph, additional, McCandless, Brian, additional, Orgera, Marisa, additional, Arif, Imran, additional, Kerr, Hanan, additional, Trejo (Gutierrez), Jorge F., additional, Fletcher, Gerald, additional, Lane, Gary E., additional, Neeson, Lynn M., additional, Parikh, Pragnesh P., additional, Pollak, Peter M., additional, Shapiro, Brian P., additional, Landolfo, Kevin, additional, Gemignani, Anthony, additional, O’Rourke, Daniel, additional, Meadows, Judith L., additional, Call, Jason T., additional, Hannan, Joseph, additional, Bojar, Robert, additional, Kumar, Deepti, additional, Mukai, John, additional, Martin, Edward T., additional, Vorobiof, Gabriel, additional, Moorman, Alec, additional, Kinlay, Scott, additional, Hamburger, Robert J., additional, Rocco, Thomas P., additional, Bhatt, Deepak L., additional, Croce, Kevin, additional, Quin, Jacquelyn A., additional, Anumpa, Jati, additional, Zenati, Marco, additional, Faxon, David P., additional, Rayos, Glenn, additional, Seedhom, Ashraf, additional, Sullenberger, Lance, additional, Kumkumian, Gregory, additional, Sedlis, Steven P., additional, Donnino, Robert M., additional, Lorin, Jeffrey, additional, Tamis‐Holland, Jacqueline E., additional, Kornberg, Robert, additional, Leber, Robert, additional, Saba, Souheil, additional, Lee, Michael W., additional, Small, Delano R., additional, Nona, Wassim, additional, Alexander, Patrick B., additional, Rehman, Iram, additional, Badami, Umesh, additional, Marzo, Kevin, additional, Robbins, Inga H., additional, Levite, Howard A., additional, Shetty, Sanjay, additional, Patel, Mayuri, additional, Hamroff, Glenn S., additional, Little, Raymond W., additional, Zimbelman, Brandi D., additional, Lui, Charles Y., additional, Smith, Brigham R., additional, Vezina, Daniel P., additional, Khor, Lillian L., additional, Abraham, Josephine D., additional, Bull, David A., additional, McKellar, Stephen H., additional, Kotter, John, additional, Hu, Bob, additional, Labovitz, Arthur J., additional, Berlowitz, Michael, additional, Matar, Fadi, additional, Rodriguez, Fatima, additional, Schnittger, Ingela, additional, Fearon, William F., additional, Deedwania, Prakash, additional, Reddy, Kiran, additional, Sweeny, Joseph, additional, Spizzieri, Christopher, additional, Hochberg, Claudia P., additional, Salerno, William D., additional, Wyman, Ray, additional, Zarka, Amer, additional, Shah, Anil V., additional, Haldis, Thomas, additional, Kohn, Jeffrey A., additional, Girotra, Saket, additional, Almousalli, Omar, additional, Krishnam, Mayil S., additional, Milliken, Jeffrey C., additional, Patel, Pranav M., additional, Seto, Arnold H., additional, Harley, Kevin T., additional, Gibson, Michael A., additional, Allen, Byron J., additional, Coram, Rita, additional, Thomas, Sabu, additional, Schwartz, Ronald G., additional, Chen, Wei, additional, El Shahawy, Mahfouz, additional, Stafford, James, additional, Abernethy, William B., additional, Zurick, Andrew, additional, Meyer, Thomas M., additional, Morford, Ronald G., additional, Rutkin, Bruce, additional, Bokhari, Sabahat, additional, Sokol, Seth I., additional, Meisner, Jay, additional, Hamzeh, Ihab, additional, Misra, Arunima, additional, Wall, Matthew, additional, De Rosen, Veronica Lenges, additional, Alam, Mahboob, additional, Turner, Michael C., additional, Mulhearn, Thomas J., additional, Good, Arnold P., additional, Shammas, Nicolas W., additional, Chilton, Robert, additional, Nguyen, Patricia K., additional, Jezior, Matthew, additional, Gordon, Paul C., additional, Crain, Thomas, additional, Stenberg, Robert, additional, Pedalino, Ronald P., additional, Wiesel, Joseph, additional, Juang, George J., additional, Al‐Amoodi, Mohammed, additional, Wohns, David, additional, Lader, Ellis W., additional, Mumma, Michael, additional, Dharmarajan, Lekshmi, additional, McGarvey, Joseph F. X., additional, Downes, Thomas R., additional, Luckasen, Gary J., additional, Cheong, Benjamin, additional, Potluri, Srinivasa, additional, Mastouri, Ronald A., additional, Breall, Jeffery A., additional, Revtyak, George E., additional, Bazeley, Jonathan W., additional, Li, Dayuan, additional, Giedd, Kenneth, additional, Old, Wayne, additional, Burt, Francis, additional, Sokhon, Kozhaya, additional, Gopal, Deepika, additional, Valeti, Uma S., additional, Kobashigawa, Jon, additional, Govindan, Sajeev Chakanalil, additional, Nair, Rajesh Gopalan, additional, Manjunath, Cholenahally Nanjappa, additional, Moorthy, Nagaraja, additional, Manjunath, Satvic Cholenahally, additional, Narayanappa, Suryaprakash, additional, Pandit, Neeraj, additional, Nath, Ranjit Kumar, additional, Dwivedi, S. K., additional, Narain, V. S., additional, Chandra, Sharad, additional, Wander, Gurpreet S., additional, Tandon, Rohit, additional, Ralhan, Sarju, additional, Aslam, Naved, additional, Goyal, Abhishek, additional, Bhargava, Balram, additional, Karthikeyan, G., additional, Ramakrishnan, S., additional, Seth, Sandeep, additional, Yadav, Rakesh, additional, Singh, Sandeep, additional, Roy, Ambuj, additional, Parakh, Neeraj, additional, Verma, Sunil Kumar, additional, Narang, Rajiv, additional, Mishra, Sundeep, additional, Naik, Nitish, additional, Sharma, Gautam, additional, Choudhary, Shiv Kumar, additional, Patel, Chetan, additional, Gulati, Gurpreet, additional, Sharma, Sanjeev, additional, Bahl, V. K., additional, Mathew, Anoop, additional, Punnoose, Eapen, additional, Gadkari, Milind Avdhoot, additional, Gadage, Siddharth, additional, Pillay, Tapan Umesh, additional, Satheesh, Santhosh, additional, Mathur, Atul, additional, Kaul, Upendra, additional, Christopher, Johann, additional, Menon, Rajeev, additional, Kumar, Nirmal, additional, Oomman, Abraham, additional, Mao, Robert, additional, Solomon, Hilda, additional, Naik, Sudhir, additional, Khan, Sajeeda Parveen, additional, Grant, Purvez, additional, Kachru, Ranjan, additional, Ajit Kumar, V. K., additional, Ganapathi, Sanjay, additional, Jayakumar, K., additional, Sivadasanpillai, Harikrishnan, additional, Sasidharan, Bijulal, additional, Kapilamoorthy, T. R., additional, Polamuri, Praneeth, additional, Senior, Roxy, additional, Gurunathan, Sothinathan, additional, Karogiannis, Nikolaos, additional, Shah, Benoy N., additional, Trimlett, Richard HJ, additional, Rubens, Michael B., additional, Nicol, Edward D., additional, Mittal, Tarun K., additional, Hampson, Reinette, additional, Gamma, Reto Andreas, additional, de Belder, Mark A., additional, Thambyrajah, Jeet, additional, Nageh, Thuraia, additional, Davies, John R., additional, Lindsay, Steven J., additional, Kurian, John, additional, Jamil, Haqeel, additional, Raheem, Osama, additional, Hoye, Angela, additional, Donnelly, Patrick, additional, Valecka, Bernardas, additional, Chauhan, Anoop, additional, Barr, Craig, additional, Alfakih, Khaled, additional, Byrne, Jonathan, additional, Webb, Ian, additional, Henriksen, Peter, additional, OKane, Peter, additional, de Silva, Ramesh, additional, Conway, Dwayne S. G., additional, Sirker, Alexander A, additional, Hoole, Stephen P., additional, Witherow, Fraser N., additional, Johnston, Nicola, additional, Harbinson, Mark, additional, Walsh, Simon, additional, Douglas, Hanna, additional, Luckie, Matthew, additional, Sobolewska, Jolanta, additional, Jeetley, Paramjit, additional, Patel, Niket, additional, Kotecha, Tushar, additional, Travill, Christopher, additional, Karimullah, Iqbal, additional, Al‐Bustami, Mahmud, additional, Braganza, Denise, additional, Henderson, Robert, additional, Pointon, Kate, additional, Naik, Surendra, additional, Mathew, Thomas, additional, Berry, Colin, additional, Collison, Damien, additional, Roditi, Giles, additional, Moriarty, Andrew J., additional, Glover, Jason D., additional, Pradhan, Jiwan, additional, Mikhail, Ghada, additional, Francis, Darrel P., additional, Gosselin, Gilbert, additional, Diaz, Ariel, additional, Rheault, Philippe, additional, Barrero, Miguel, additional, Gagné, Carl‐Éric, additional, Pépin‐Dubois, Yanek, additional, Costa, Ricardo, additional, Sia, Ying Tung, additional, Lemay, Catherine, additional, Gisbert, Alejandro, additional, Gervais, Pierre, additional, Rheault, Alain, additional, Phaneuf, Denis Carl, additional, Garg, Pallav, additional, Chow, Benjamin J. W., additional, Hessian, Renee C., additional, Beanlands, Rob S., additional, Davies, Richard F., additional, Bainey, Kevin R., additional, Cheema, Asim N., additional, Bagai, Akshay, additional, Wald, Ron, additional, Goodman, Shaun, additional, Graham, John Joseph, additional, Peterson, Mark, additional, Chow, Chi‐Ming, additional, Abramson, Beth, additional, Cheema, Asim Nazir, additional, Vakani, Mohammad Tariq, additional, Cha, James, additional, Howarth, Andrew G, additional, Wong, Graham, additional, Uxa, Amar, additional, Galiwango, Paul, additional, Kassam, Saleem, additional, Mukherjee, Ashok, additional, Ricci, A. Joseph, additional, Lam, Andy, additional, Mehta, Shamir, additional, Udell, Jacob, additional, Généreux, Philippe, additional, Hameed, Adnan, additional, Daba, Ledjalem, additional, Hueb, Whady, additional, Rezende, Paulo Cury, additional, Silva, Expedito Eustáquio Ribeiro, additional, Hueb, Alexandre Ciappina, additional, Smanio, Paola Emanuela Poggio, additional, de Quadros, Alexandre Schaan, additional, Kalil, Renato Abdala Karam, additional, da Costa Vieira, José Luiz, additional, Grossmann, Gabriel, additional, de Oliveira, Pedro Píccaro, additional, Bridi, Leonardo, additional, Savaris, Simone, additional, Vitola, João V., additional, Cerci, Rodrigo J., additional, Farias, Fabio R., additional, Fernandes, Miguel M., additional, Marin‐Neto, José Antonio, additional, Schmidt, André, additional, de Oliveira Lima Filho, Moysés, additional, Oliveira, Ricardo Mendes, additional, Chierice, João Reynaldo Abbud, additional, Polanczyk, Carísi A., additional, Furtado, Mariana V., additional, Smidt, Luis F., additional, Carvalho, Antonio Carlos, additional, Pucci, Gustavo, additional, Lyra, Flavio, additional, Junior, Alvaro Rabelo Alves, additional, Dracoulakis, Marianna D. A., additional, Lima, Rodolfo G. S. D, additional, Figueiredo, Estevao, additional, Caramori, Paulo Ricardo, additional, Tumelero, Rogerio, additional, Dall’Orto, Frederico, additional, Mesquita, Claudio T., additional, Colafranseschi, Alexandre S., additional, Oliveira, Amarino C., additional, Carvalho, Luiz A., additional, Palazzo, Isabella C., additional, Sousa, Andre S., additional, da Silva, Expedito Eustáquio Ribeiro, additional, de Barros, Pedro Gabriel Melo, additional, de Pádua Silva Baptista, Luciana, additional, Rodrigues, Marcelo Jamus, additional, de Resende, Marcos Valério Coimbra, additional, Saraiva, Jose Francisco, additional, Costantini, Costantino, additional, Demkow, Marcin, additional, Pracon, Radoslaw, additional, Kepka, Cezary, additional, Teresinska, Anna, additional, Kryczka, Karolina, additional, Henzel, Jan, additional, Solecki, Mateusz, additional, Kaczmarska, Edyta, additional, Mazurek, Tomasz, additional, Drozdz, Jaroslaw, additional, Czarniak, Bartosz, additional, Frach, Malgorzata, additional, Szymczyk, Konrad, additional, Niedzwiecka, Iwona, additional, Sobczak, Sebastian, additional, Ciurus, Tomasz, additional, Jakubowski, Piotr, additional, Misztal‐Teodorczyk, Magdalena, additional, Teodorczyk, Dawid, additional, Fratczak, Aleksandra, additional, Szkopiak, Marcin, additional, Lebioda, Patrycja, additional, Wlodarczyk, Michal, additional, Plachcinska, Anna, additional, Kusmierek, Jacek, additional, Miller, Magdalena, additional, Marciniak, Halina, additional, Wojtczak‐Soska, Karolina, additional, Luczak, Katarzyna, additional, Tarchalski, Tomasz, additional, Cichocka‐Radwan, Anna, additional, Szwed, Hanna, additional, Szulczyk, Grazyna Anna, additional, Witkowski, Adam, additional, Kukula, Krzysztof, additional, Celinska‐Spodar, Malgorzta, additional, Zalewska, Joanna, additional, Gajos, Grzegorz, additional, Bury, Krzysztof, additional, Pruszczyk, Piotr, additional, Roik, Marek, additional, Loboz‐Grudzien, Krystyna, additional, Sokalski, Leszek, additional, Brzezinska, Barbara, additional, Lesiak, Maciej, additional, Lanocha, Magdalena, additional, Reczuch, Krzysztof W., additional, Kalarus, Zbigniew, additional, Swiatkowski, Andrzej, additional, Szulik, Mariola, additional, Musial, Wlodzimierz J., additional, Bockeria, Leo, additional, Petrosyan, Karen, additional, Trifonova, Tatiana, additional, Chernyavskiy, Alexander M., additional, Kretov, Evgeniy I., additional, Grazhdankin, Igor O., additional, Bershtein, Leonid L., additional, Sayganov, Sergey A., additional, Kuzmina‐Krutetskaya, Anastasia M., additional, Zbyshevskaya, Elizaveta V., additional, Katamadze, Nana O., additional, Demchenko, Elena A., additional, Kozlov, Pavel S., additional, Kozulin, Vikentiy Y., additional, Lubinskaya, Ekaterina I., additional, Lopez‐Sendon, Jose, additional, Castro, Almudena, additional, Salicio, Elena Refoyo, additional, Guzman, Gabriela, additional, Galeote, Gabriel, additional, Valbuena, Silvia, additional, Peteiro, Jesús, additional, Martínez‐Ruíz, María Dolores, additional, Pérez‐Fernández, Ruth, additional, Cuenca‐Castillo, José J., additional, Flores‐Ríos, Xacobe, additional, Prada‐Delgado, Óscar, additional, Barge‐Caballero, Gonzalo, additional, Juanatey, Jose Ramon Gonzalez, additional, Bayarri, Miguel Souto, additional, Nuñez, Virginia Pubull, additional, Sanchez, Raymundo Ocaranza, additional, Alvarez, Belen Cid, additional, Gil, Carlos Peña, additional, Monzonis, Amparo Martinez, additional, Sionis, Alessandro, additional, Perales, Montserrat Vila, additional, Padró, Josep Maria, additional, Peñaranda, Antonio Serra, additional, Picart, Joan García, additional, Iglesias, Antonino Ginel, additional, Marimon, Xavier Garcia‐Moll, additional, Lladó, Guillem Pons, additional, Costa, Francesc Carreras, additional, Miro, Vicente, additional, Diez, Jose L., additional, Calvillo, Pilar, additional, Ortuño, F. Marin, additional, Chávarri, M. Valdés, additional, Montolliu, A. Tello, additional, Bermudez, E. Pinar, additional, De La Morena, G., additional, Blancas, Montserrat Gracida, additional, Luena, Jose Enrique Castillo, additional, Fernandez‐Aviles, Francisco, additional, Chen, Jiyan, additional, Wu, Yongjian, additional, Ma, Yitong, additional, Yang, Yining, additional, Ji, Zheng, additional, Yang, Xinchun, additional, Lin, Wenhua, additional, Zeng, Hesong, additional, Fu, Xin, additional, Yang, Bin, additional, Wang, Songtao, additional, Cheng, Gong, additional, Zhao, Yulan, additional, Fang, Xuehua, additional, Zeng, Qiutang, additional, Su, Xi, additional, Li, Qingxian, additional, Nie, Shao‐ping, additional, Yu, Qin, additional, Wang, Jian’an, additional, Zhang, Shuyang, additional, Liu, Zhenyu, additional, Perna, Gian Piero, additional, Marini, Marco, additional, Gabrielli, Gabriele, additional, Provasoli, Stefano, additional, Verna, Edoardo, additional, Monti, Lorenzo, additional, Nardi, Barbara, additional, Di Chiara, Antonio, additional, Mortara, Andrea, additional, Galvani, Marcello, additional, Ottani, Filippo, additional, Sicuro, Marco, additional, Calabro, Paolo, additional, Formisano, Tiziana, additional, Tarantini, Giuseppe, additional, Cucchini, Umberto, additional, Andres, Anto Luigi, additional, Racca, Emanuela, additional, Briguori, Carlo, additional, Amati, Roberto, additional, Vergoni, William, additional, Russo, Aldo, additional, Fanelli, Raffaele, additional, Poh, Kian‐Keong, additional, Chai, Ping, additional, Lau, Titus, additional, Loh, Joshua P., additional, Tay, Edgar L., additional, Teoh, Kristine, additional, Teo, Lynette L., additional, Ong, Ching‐Ching, additional, Wong, Raymond C., additional, Loh, Poay‐Huan, additional, Kofidis, Theodoros, additional, Chan, Wan Xian, additional, Chan, Koo Hui, additional, Foo, David, additional, Kong, Jason Loh Kwok, additional, Er, Ching Min, additional, Jafary, Fahim Haider, additional, Chua, Terrance, additional, Doerr, Rolf, additional, Stumpf, Juergen, additional, Matschke, Klaus, additional, Simonis, Gregor, additional, Kadalie, Clemens T., additional, Sechtem, Udo, additional, Ong, Peter, additional, Schulze, P. Christian, additional, Goebel, Bjoern, additional, Lenk, Karsten, additional, Nickenig, Georg, additional, Schuchlenz, Herwig, additional, Weikl, Stefan, additional, Lang, Irene Marthe, additional, Huber, Kurt, additional, Jakl‐Kotauschek, Gabriele, additional, Vertes, Andras, additional, Varga, Albert, additional, Fontos, Geza, additional, Merkely, Bela, additional, Kerecsen, Gabor, additional, Hinic, Sasa, additional, Zdravkovic, Marija, additional, Mudrenovic, Vladan, additional, Crnokrak, Bogdan, additional, Beleslin, Branko D., additional, Boskovic, Nikola N., additional, Petrovic, Marija T., additional, Dobric, Milan R., additional, Markovic, Zeljko Z., additional, Mladenovic, Ana S., additional, Cemerlic‐Adjic, Nada, additional, Davidovic, Goran, additional, Vucic, Rada, additional, Dekleva, Milica Nikola, additional, Stankovic, Goran, additional, Apostolovic, Svetlana, additional, Escobedo, Jorge, additional, Baleón‐Espinosa, Rubén, additional, Campos‐Santaolalla, Arturo S., additional, Durán‐Cortés, Elihú, additional, Flores‐Palacios, José M., additional, García‐Rincón, Andrés, additional, Jiménez‐Santos, Moisés, additional, Peñafiel, Joaquín V., additional, Ortega‐Ramírez, José A., additional, Valdespino‐Estrada, Aquiles, additional, Rosas, Erick Alexánderson, additional, Selvanayagam, Joseph B., additional, Joseph, Majo X., additional, Thambar, Suku T., additional, Beltrame, John F., additional, Hillis, Graham S., additional, Thuaire, Christophe, additional, Dutoiu, Téodora, additional, Steg, Philippe Gabriel, additional, Juliard, Jean‐Michel, additional, Slama, Michel S., additional, El Mahmoud, Rami, additional, Nicollet, Eric, additional, Goube, Pascal, additional, Barone‐Rochette, Gilles, additional, Furber, Alain, additional, Bière, Loïc, additional, Laucevicius, Aleksandras, additional, Celutkiene, Jelena, additional, Kedhi, Elvin, additional, Timmer, Jorik, additional, Hermanides, Rik, additional, Kaplan, Eliza, additional, Riezebos, Robert K., additional, Samadi, Pouneh, additional, van Dongen, Elise, additional, Niehe, Sander R., additional, Suryapranata, Harry, additional, van Vugt, Stijn, additional, Ramos, Ruben, additional, Cacela, Duarte, additional, Santana, Ana, additional, Fiarresga, Antonio, additional, Sousa, Lidia, additional, Marques, Hugo, additional, Patricio, Lino, additional, Bernanrdes, Luis, additional, Rio, Pedro, additional, Carvalho, Ramiro, additional, Ferreira, Rui, additional, Silva, Tiago, additional, Rodrigues, Ines, additional, Modas, Pedro, additional, Portugal, Guilherme, additional, Fragata, Jose, additional, Pinto, Fausto J., additional, Menezes, Miguel Nobre, additional, Lopes, Guilhermina Cantinho, additional, Almeida, Ana Gomes, additional, Silva, Pedro Canas, additional, Nobre, Angelo, additional, Francisco, Ana Rita, additional, Ferreira, Nuno, additional, Lopes, Ricardo L., additional, Guzman, Luis, additional, Figal, Julio César, additional, Méndiz, Oscar, additional, Cortés, Claudia, additional, Favaloro, Roberto René, additional, Alvarez, Carlos, additional, Courtis, Javier, additional, Zeballos, Gabriela, additional, Schiavi, Lilia, additional, Rubio, Mariano, additional, Devlin, Gerard Patrick, additional, Fisher, Raewyn, additional, Stewart, Ralph Alan Huston, additional, White, Harvey Douglas, additional, Benatar, Jocelyne, additional, Kedev, Sasko, additional, Mitevska, Irena Peovska, additional, Kostovska, Elizabeta Srbinovska, additional, Pejkov, Hristo, additional, Eggers, Kai, additional, Frostfelt, Gunnar, additional, Johnston, Nina, additional, Olsowka, Maciej, additional, Åkerblom, Axel, additional, Soveri, Inga, additional, Aspberg, Johannes, additional, Sharir, Tali, additional, Elian, Dan, additional, Kerner, Arthur, additional, Massalha, Samia, additional, Fukuda, Keiichi, additional, Kohsaka, Shun, additional, Yasuda, Satoshi, additional, Nishimura, Shigeyuki, additional, Van de Werf, Frans, additional, Claes, Kathleen, additional, Hung, Chung‐Lieh, additional, Yun, Chun‐Ho, additional, Hou, Charles Jia‐Yin, additional, Kuo, Jen‐Yuan, additional, Yeh, Hung‐I, additional, Hung, Ta‐Chuan, additional, Li, Jiun‐Yi, additional, Chien, Chen‐Yen, additional, Tsai, Cheng‐Ting, additional, Liu, Chun‐Chieh, additional, Yu, Fa‐Chang, additional, Lin, Yueh‐Hung, additional, Lan, Wei‐Ren, additional, Yen, Chih‐Hsuan, additional, Tsai, Jui‐Peng, additional, Sung, Kuo‐Tzu, additional, Ntsekhe, Mpiko, additional, Pandie, Shaheen, additional, Viljoen, Charle A., additional, De Andrade, Marianne, additional, Moccetti, Tiziano, additional, Rossi, M. Grazia, additional, Abdelhamid, Magdy, additional, Adel, Ahmed, additional, Kamal, Ahmed, additional, Mahrous, Hossam, additional, El Kaffas, Sameh, additional, El Fishawy, Hussien, additional, Pop, Calin, additional, Claudia, Matei, additional, Popescu, Bogdan A., additional, Ginghina, Carmen, additional, Deleanu, Dan, additional, Iliescu, Vlad A., additional, Al‐Mallah, Mouaz H., additional, Aljzeeri, Ahmed, additional, Najm, Hani, additional, Alghamdi, Ali, additional, Ramos, Walter Enrique Mogrovejo, additional, Kuanprasert, Srun, additional, Prommintikul, Arintaya, additional, Nawarawong, Weerachai, additional, Woragidpoonpol, Surin, additional, Tepsuwan, Thitipong, additional, Taksaudom, Noppon, additional, Rimsukcharoenchai, Chataroon, additional, Euathrongchit, Juntima, additional, Wannasopha, Yutthaphan, additional, Yamwong, Sukit, additional, Sritara, Piyamitr, additional, Aramcharoen, Suthara, additional, Meemuk, Krissada, additional, Khairuddin, Ahmad, additional, Hadi, Hafidz Abd, additional, and Yahaya, Shaiful Azmi, additional
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- 2024
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40. Automated echocardiographic left ventricular dimension assessment in dogs using artificial intelligence: Development and validation
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Stowell, Catherine C., primary, Kallassy, Valeria, additional, Lane, Beth, additional, Abbott, Jonathan, additional, Borgeat, Kieran, additional, Connolly, David, additional, Domenech, Oriol, additional, Dukes‐McEwan, Joanna, additional, Ferasin, Luca, additional, Del Palacio, Josefa Fernández, additional, Linney, Chris, additional, Matos, Jose Novo, additional, Spalla, Ilaria, additional, Summerfield, Nuala, additional, Vezzosi, Tommaso, additional, Howard, James P., additional, Shun‐Shin, Matthew J., additional, Francis, Darrel P., additional, and Fuentes, Virginia Luis, additional
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- 2024
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41. Association of troponin level and age with mortality in 250 000 patients : cohort study across five UK acute care centres
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Kaura, Amit, Panoulas, Vasileios, Glampson, Benjamin, Davies, Jim, Mulla, Abdulrahim, Woods, Kerrie, Omigie, Joe, Shah, Anoop D, Channon, Keith M, Weber, Jonathan N, Thursz, Mark R, Elliott, Paul, Hemingway, Harry, Williams, Bryan, Asselbergs, Folkert, O’Sullivan, Michael, Kharbanda, Rajesh, Lord, Graham M, Melikian, Narbeh, Patel, Riyaz S, Perera, Divaka, Shah, Ajay M, Francis, Darrel P, and Mayet, Jamil
- Published
- 2019
42. The impact of artificial intelligence on clinical education: perceptions of postgraduate trainee doctors in London (UK) and recommendations for trainers
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Banerjee, Maya, Chiew, Daphne, Patel, Keval T., Johns, Ieuan, Chappell, Digby, Linton, Nick, Cole, Graham D., Francis, Darrel P., Szram, Jo, Ross, Jack, and Zaman, Sameer
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- 2021
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43. An optimisation-based iterative approach for speckle tracking echocardiography
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Azarmehr, Neda, Ye, Xujiong, Howes, Joseph D., Docking, Benjamin, Howard, James P., Francis, Darrel P., and Zolgharni, Massoud
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- 2020
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44. Artificial Intelligence for Aortic Pressure Waveform Analysis During Coronary Angiography: Machine Learning for Patient Safety
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Howard, James P., Cook, Christopher M., van de Hoef, Tim P., Meuwissen, Martijn, de Waard, Guus A., van Lavieren, Martijn A., Echavarria-Pinto, Mauro, Danad, Ibrahim, Piek, Jan J., Götberg, Matthias, Al-Lamee, Rasha K., Sen, Sayan, Nijjer, Sukhjinder S., Seligman, Henry, van Royen, Niels, Knaapen, Paul, Escaned, Javier, Francis, Darrel P., Petraco, Ricardo, and Davies, Justin E.
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- 2019
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45. Meta-Analysis of Randomized Controlled Trials of Atrial Fibrillation Ablation With Pulmonary Vein Isolation Versus Without
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Sau, Arunashis, Howard, James P., Al-Aidarous, Sayed, Ferreira-Martins, João, Al-Khayatt, Becker, Lim, P. Boon, Kanagaratnam, Prapa, Whinnett, Zachary I., Peters, Nicholas S., Sikkel, Markus B., Francis, Darrel P., and Sohaib, S.M. Afzal
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- 2019
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46. Quantification of Electromechanical Coupling to Prevent Inappropriate Implantable Cardioverter-Defibrillator Shocks
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Keene, Daniel, Shun-Shin, Matthew J., Arnold, Ahran D., Howard, James P., Lefroy, David, Davies, D. Wyn, Lim, Phang Boon, Ng, Fu Siong, Koa-Wing, Michael, Qureshi, Norman A., Linton, Nick W.F., Shah, Jaymin S., Peters, Nicholas S., Kanagaratnam, Prapa, Francis, Darrel P., and Whinnett, Zachary I.
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- 2019
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47. Cardiac Rhythm Device Identification Using Neural Networks
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Howard, James P., Fisher, Louis, Shun-Shin, Matthew J., Keene, Daniel, Arnold, Ahran D., Ahmad, Yousif, Cook, Christopher M., Moon, James C., Manisty, Charlotte H., Whinnett, Zach I., Cole, Graham D., Rueckert, Daniel, and Francis, Darrel P.
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- 2019
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48. His Resynchronization Versus Biventricular Pacing in Patients With Heart Failure and Left Bundle Branch Block
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Arnold, Ahran D., Shun-Shin, Matthew J., Keene, Daniel, Howard, James P., Sohaib, S.M. Afzal, Wright, Ian J., Cole, Graham D., Qureshi, Norman A., Lefroy, David C., Koa-Wing, Michael, Linton, Nick W.F., Lim, Phang Boon, Peters, Nicholas S., Davies, D. Wyn, Muthumala, Amal, Tanner, Mark, Ellenbogen, Kenneth A., Kanagaratnam, Prapa, Francis, Darrel P., and Whinnett, Zachary I.
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- 2018
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49. Catheter Ablation for Ventricular Tachycardia After MI: A Reconstructed Individual Patient Data Meta-analysis of Randomised Controlled Trials
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Reddy, Rohin K, primary, Howard, James P, additional, Ahmad, Yousif, additional, Shun-Shin, Matthew J, additional, Simader, Florentina A, additional, Miyazawa, Alejandra A, additional, Saleh, Keenan, additional, Naraen, Akriti, additional, Samways, Jack W, additional, Katritsis, George, additional, Mohal, Jagdeep S, additional, Kaza, Nandita, additional, Porter, Bradley, additional, Keene, Daniel, additional, Linton, Nicholas WF, additional, Francis, Darrel P, additional, Whinnett, Zachary I, additional, Luther, Vishal, additional, Kanagaratnam, Prapa, additional, and Arnold, Ahran D, additional
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- 2023
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50. A Placebo-Controlled Trial of Percutaneous Coronary Intervention for Stable Angina
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Rajkumar, Christopher A., primary, Foley, Michael J., additional, Ahmed-Jushuf, Fiyyaz, additional, Nowbar, Alexandra N., additional, Simader, Florentina A., additional, Davies, John R., additional, O’Kane, Peter D., additional, Haworth, Peter, additional, Routledge, Helen, additional, Kotecha, Tushar, additional, Gamma, Reto, additional, Clesham, Gerald, additional, Williams, Rupert, additional, Din, Jehangir, additional, Nijjer, Sukhjinder S., additional, Curzen, Nick, additional, Ruparelia, Neil, additional, Sinha, Manas, additional, Dungu, Jason N., additional, Ganesananthan, Sashiananthan, additional, Khamis, Ramzi, additional, Mughal, Lal, additional, Kinnaird, Tim, additional, Petraco, Ricardo, additional, Spratt, James C., additional, Sen, Sayan, additional, Sehmi, Joban, additional, Collier, David J., additional, Sohaib, Afzal, additional, Keeble, Thomas R., additional, Cole, Graham D., additional, Howard, James P., additional, Francis, Darrel P., additional, Shun-Shin, Matthew J., additional, and Al-Lamee, Rasha K., additional
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- 2023
- Full Text
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