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2. Clopidogrel-Mediated P2Y12 Inhibition According to Renal Function in Patients With Diabetes Mellitus and CAD

Author

Ortega-Paz, Luis, Franchi, Francesco, Rollini, Fabiana, Galli, Mattia, Been, Latonya, Ghanem, Ghussan, Shalhoub, Awss, Ossi, Tiffany, Rivas, Andrea, Zhou, Xuan, Pineda, Andres M., Suryadevara, Siva, Soffer, Daniel, Zenni, Martin M., Mahowald, Madeline K., Langaee, Taimour, Jakubowski, Joseph A., Cavallari, Larisa H., and Angiolillo, Dominick J.

Published
2024
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3. P2Y12 Inhibition in Patients Requiring Oral Anticoagulation After Percutaneous Coronary Intervention: The SWAP-AC–2 Study

Author

Ortega-Paz, Luis, Bor, Wilbert, Franchi, Francesco, van den Broek, Wout W.A., Rollini, Fabiana, Giordano, Salvatore, Galli, Mattia, Been, Latonya, Ghanem, Ghussan, Shalhoub, Awss, Garabedian, Haroutioun, Al Saleh, Tala, Uzunoglu, Ekin, Zhou, Xuan, Rivas, Andrea, Pineda, Andres M., Suryadevara, Siva, Soffer, Daniel, Mahowald, Madeline K., Choi, Calvin Y., Zenni, Martin M., Phoenix, Fladia, Ajjan, Ramzi A., ten Berg, Jurrien M., and Angiolillo, Dominick J.

Published
2024
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4. Effectiveness of Clopidogrel vs Alternative P2Y12 Inhibitors Based on the ABCD-GENE Score

Author

Thomas, Cameron D., Franchi, Francesco, Rossi, Joseph S., Keeley, Ellen C., Anderson, R. David, Beitelshees, Amber L., Duarte, Julio D., Ortega-Paz, Luis, Gong, Yan, Kerensky, Richard A., Kulick, Natasha, McDonough, Caitrin W., Nguyen, Anh B., Wang, Yehua, Winget, Marshall, Yang, William E., Johnson, Julie A., Winterstein, Almut G., Stouffer, George A., Angiolillo, Dominick J., Lee, Craig R., and Cavallari, Larisa H.

Published
2024
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6. Switching From Cangrelor to Prasugrel in Patients Undergoing Percutaneous Coronary Intervention: The Switching Antiplatelet-6 (SWAP-6) Study

Author

Franchi, Francesco, Rollini, Fabiana, Ortega-Paz, Luis, Been, Latonya, Giordano, Salvatore, Galli, Mattia, Ghanem, Ghussan, Garabedian, Haroutioun, Al Saleh, Tala, Uzunoglu, Ekin, Rivas, Andrea, Pineda, Andres M., Suryadevara, Siva, Soffer, Daniel, Zenni, Martin M., Mahowald, Madeline, Reiter, Birgit, Jilma, Bernd, and Angiolillo, Dominick J.

Published
2023
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7. P2Y12 inhibitor monotherapy in patients undergoing percutaneous coronary intervention

Author

Capodanno, Davide, Baber, Usman, Bhatt, Deepak L., Collet, Jean-Philippe, Dangas, George, Franchi, Francesco, Gibson, C. Michael, Gwon, Hyeon-Cheol, Kastrati, Adnan, Kimura, Takeshi, Lemos, Pedro A., Lopes, Renato D., Mehran, Roxana, O’Donoghue, Michelle L., Rao, Sunil V., Rollini, Fabiana, Serruys, Patrick W., Steg, Philippe G., Storey, Robert F., Valgimigli, Marco, Vranckx, Pascal, Watanabe, Hirotoshi, Windecker, Stephan, and Angiolillo, Dominick J.

Published
2022
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12. Novel Tissue Factor Inhibition for Thromboprophylaxis in COVID-19: Primary Results of the ASPEN-COVID-19 Trial

Author

Hess, Connie N., Hsia, Judith, Carroll, Ian A., Nehler, Mark R., Ruf, Wolfram, Morrow, David A., Nicolau, Jose C., Berwanger, Otavio, Szarek, Michael, Capell, Warren H., Johri, Shilpa, Pursley, Michael S., Gupta, Ryan, Meehan, Patrick S., Franchi, Francesco, Effron, Mark B., Marshall, Debra, Graybill, Christopher A., Huebler, Sophia P., Keuer, Thomas, Bristow, Michael R., and Bonaca, Marc P.

Published
2023
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13. Defining Strategies of Modulation of Antiplatelet Therapy in Patients With Coronary Artery Disease: A Consensus Document from the Academic Research Consortium

Author

Capodanno, Davide, Mehran, Roxana, Krucoff, Mitchell W., Baber, Usman, Bhatt, Deepak L., Capranzano, Piera, Collet, Jean-Philippe, Cuisset, Thomas, De Luca, Giuseppe, De Luca, Leonardo, Farb, Andrew, Franchi, Francesco, Gibson, C. Michael, Hahn, Joo-Yong, Hong, Myeong-Ki, James, Stefan, Kastrati, Adnan, Kimura, Takeshi, Lemos, Pedro A., Lopes, Renato D., Magee, Adrian, Matsumura, Ryosuke, Mochizuki, Shuichi, O’Donoghue, Michelle L., Pereira, Naveen L., Rao, Sunil V., Rollini, Fabiana, Shirai, Yuko, Sibbing, Dirk, Smits, Peter C., Steg, P. Gabriel, Storey, Robert F., ten Berg, Jurrien, Valgimigli, Marco, Vranckx, Pascal, Watanabe, Hirotoshi, Windecker, Stephan, Serruys, Patrick W., Yeh, Robert W., Morice, Marie-Claude, and Angiolillo, Dominick J.

Published
2023
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14. Evaluating the Effect of Estimating Renal Function With the CKD‐EPI 2021 Equation on the ABCD‐GENE Score for Clopidogrel Response Prediction.

Author

AlSaeed, Maryam Jamal, Thomas, Cameron D., Franchi, Francesco, Keeley, Ellen C., Duarte, Julio D., Gong, Yan, Rossi, Joseph S., Beitelshees, Amber L., Stouffer, George A., Lee, Craig R., Angiolillo, Dominick J., and Cavallari, Larisa H.

Subjects
PERCUTANEOUS coronary intervention, GLOMERULAR filtration rate, CHRONIC kidney failure, BODY mass index, BLACK people
Abstract

The ABCD‐GENE score was developed to predict poor response to clopidogrel and includes Age, Body mass index, Chronic kidney disease (CKD; estimated glomerular filtration rate [eGFR] < 60 mL/min/1.73 m2), Diabetes, and CYP2C19 GENE variants; a score ≥ 10 is predictive of reduced clopidogrel effectiveness after percutaneous coronary intervention (PCI). Estimation of GFR without a race variable via the CKD‐EPI Scr 2021 equation is now recommended. We examined the impact of using the CKD‐EPI Scr 2021 vs. 2009 equation on the ABCD‐GENE score for post‐PCI patients. A total of 4335 adult patients (n = 925 Black) who underwent PCI and CYP2C19 genotyping were included, with GFR estimated for each patient via the CKD‐EPI Scr 2021 and CKD‐EPI 2009 equations. The ABCD‐GENE score, calculated based on each GFR estimation, was compared. With the CKD‐EPI Scr 2021 vs. 2009 equation, median (IQR) eGFR was lower (74 [55–94] vs. 81 [60–103] mL/min/1.73 m2, P < 0.001), and CKD prevalence was higher (31% vs. 25%, P < 0.001) among Black patients, whereas eGFR was higher (85 [65–99] vs. 80 [61–94] mL/min/1.73m2, P < 0.001), and CKD prevalence was lower (20% vs. 24%, P < 0.001) in non‐Black patients. This led to 12 (1%) Black patients being reclassified from low to high risk of poor clopidogrel response and 30 (1%) non‐Black patients being recategorized from high to low risk (P < 0.001 for both comparisons). Removal of the race variable from GFR estimation significantly impacted the prediction of clopidogrel effectiveness via the ABCD‐GENE score. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Abstract 11054: Switching From Dual Antiplatelet Treatment Regimens With Aspirin Plus a P2Y12 Inhibitor to Dual Pathway Inhibition With Low-Dose Rivaroxaban in Adjunct to Aspirin in Patients With Coronary Artery Disease&colon; The SWAP-AC Study

Author

Ortega-Paz, Luis G., Rollini, Fabiana, Galli, Mattia, Been, Latonya, Ghanem, Ghussan, Shalhoub, Awss, Ossi, Tiffany, Rivas, Andrea, Zhou, Xuan, Pineda, Andres, Suryadevara, Siva, Soffer, Daniel, Zenni, Martin, Angiolillo, Dominick J, and Franchi, Francesco

Published
2022
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20. Precision Antiplatelet Therapy after Percutaneous Coronary Intervention (Precision PCI) Registry – Informing optimal antiplatelet strategies.

Author

Cavallari, Larisa H., Lee, Craig R., Franchi, Francesco, Keeley, Ellen C., Rossi, Joseph S., Thomas, Cameron D., Gong, Yan, McDonough, Caitrin W., Starostik, Petr, Al Saeed, Maryam J., Been, Latonya, Kulick, Natasha, Malave, Jean, Mulrenin, Ian R., Nguyen, Anh B., Terrell, Joshua N., Tillotson, Grace, Beitelshees, Amber L., Winterstein, Almut G., and Stouffer, George A.

Subjects
PLATELET aggregation inhibitors, PERCUTANEOUS coronary intervention, PLATELET function tests, CYTOCHROME P-450 CYP2C19, PRASUGREL
Abstract

Dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 receptor inhibitor (clopidogrel, prasugrel, or ticagrelor) is indicated after percutaneous coronary intervention (PCI) to reduce the risk of atherothrombotic events. Approximately 30% of the US population has a CYP2C19 no‐function allele that reduces the effectiveness of clopidogrel, but not prasugrel or ticagrelor, after PCI. We have shown improved outcomes with the integration of CYP2C19 genotyping into clinical care to guide the selection of prasugrel or ticagrelor in CYP2C19 no‐function allele carriers. However, the influence of patient‐specific demographic, clinical, and other genetic factors on outcomes with genotype‐guided DAPT has not been defined. In addition, the impact of genotype‐guided de‐escalation from prasugrel or ticagrelor to clopidogrel in patients without a CYP2C19 no‐function allele has not been investigated in a diverse, real‐world clinical setting. The Precision Antiplatelet Therapy after Percutaneous Coronary Intervention (Precision PCI) Registry is a multicenter US registry of patients who underwent PCI and clinical CYP2C19 testing. The registry is enrolling a diverse population, assessing atherothrombotic and bleeding events over 12 months, collecting DNA samples, and conducting platelet function testing in a subset of patients. The registry aims to define the influence of African ancestry and other patient‐specific factors on clinical outcomes with CYP2C19‐guided DAPT, evaluate the safety and effectiveness of CYP2C19‐guided DAPT de‐escalation following PCI in a real‐world setting, and identify additional genetic influences of clopidogrel response after PCI, with the ultimate goal of establishing optimal strategies for individualized antiplatelet therapy that improves outcomes in a diverse, real‐world population. [ABSTRACT FROM AUTHOR]

Published
2024
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21. CYP2C19 Genotype Is Associated With Adverse Cardiovascular Outcomes in Black Patients Treated With Clopidogrel Undergoing Percutaneous Coronary Intervention.

Author

Tunehag, Kayla R., Thomas, Cameron D., Franchi, Francesco, Rossi, Joseph S., Keeley, Ellen C., Anderson, R. David, Beitelshees, Amber L., Duarte, Julio D., Yan Gong, Kerensky, Richard A., McDonough, Caitrin W., Nguyen, Anh B., Paz, Luis Ortega, Venkatesh, Sanjay, Wang, Yehua, Johnson, Julie A., Winterstein, Almut G., Stouffer, George A., Angiolillo, Dominick J., and Cavallari, Larisa H.

Published
2024
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22. Prasugrel Versus Ticagrelor in Patients With CYP2C19 Loss-of-Function Genotypes: Results of a Randomized Pharmacodynamic Study in a Feasibility Investigation of Rapid Genetic Testing

Author

Franchi, Francesco, Rollini, Fabiana, Rivas, Jose, Rivas, Andrea, Agarwal, Malhar, Briceno, Maryuri, Wali, Mustafa, Nawaz, Ahmed, Silva, Gabriel, Shaikh, Zubair, Maailiki, Naji, Been, Latonya, Pineda, Andres M., Suryadevara, Siva, Soffer, Daniel, Zenni, Martin M., Bass, Theodore A., and Angiolillo, Dominick J.

Published
2020
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23. Pharmacodynamic Effects of Vorapaxar in Patients With and Without Diabetes Mellitus: Results of the OPTIMUS-5 Study

Author

Franchi, Francesco, Rollini, Fabiana, Kairouz, Victor, Rivas Rios, Jose, Rivas, Andrea, Agarwal, Malhar, Briceno, Maryuri, Wali, Mustafa, Nawaz, Ahmed, Silva, Gabriel, Shaikh, Zubair, Maaliki, Naji, Been, Latonya, Piraino, Jason, Pineda, Andres M., Suryadevara, Siva, Soffer, Daniel, Zenni, Martin M., Jennings, Lisa K., Bass, Theodore A., and Angiolillo, Dominick J.

Published
2019
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25. Updated Expert Consensus Statement on Platelet Function and Genetic Testing for Guiding P2Y12 Receptor Inhibitor Treatment in Percutaneous Coronary Intervention

Author

Sibbing, Dirk, Aradi, Daniel, Alexopoulos, Dimitrios, ten Berg, Jurrien, Bhatt, Deepak L., Bonello, Laurent, Collet, Jean-Philippe, Cuisset, Thomas, Franchi, Francesco, Gross, Lisa, Gurbel, Paul, Jeong, Young-Hoon, Mehran, Roxana, Moliterno, David J., Neumann, Franz-Josef, Pereira, Naveen L., Price, Matthew J., Sabatine, Marc S., So, Derek Y.F., Stone, Gregg W., Storey, Robert F., Tantry, Udaya, Trenk, Dietmar, Valgimigli, Marco, Waksman, Ron, and Angiolillo, Dominick J.

Published
2019
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26. Switching from Dual Antiplatelet Therapy with Aspirin Plus a P2Y12 Inhibitor to Dual Pathway Inhibition with Aspirin Plus Vascular-Dose Rivaroxaban: The Switching Anti-Platelet and Anti-Coagulant Therapy (SWAP-AC) Study.

Author

Ortega-Paz, Luis, Franchi, Francesco, Rollini, Fabiana, Galli, Mattia, Been, Latonya, Ghanem, Ghussan, Shalhoub, Awss, Ossi, Tiffany, Rivas, Andrea, Zhou, Xuan, Pineda, Andres M., Suryadevara, Siva, Soffer, Daniel, Zenni, Martin M., Jennings, Lisa K., and Angiolillo, Dominick J.

Published
2024
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27. Bivalirudin in acute coronary syndromes

Author

Galli, Mattia, primary, Bernardi, Marco, additional, Ortega-Paz, Luis, additional, Nerla, Roberto, additional, D’Amario, Domenico, additional, Franchi, Francesco, additional, Biondi-Zoccai, Giuseppe, additional, and Angiolillo, Dominick J., additional

Published
2023
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29. Abstract 15044: Impact of Chronic Kidney Disease on the Pharmacodynamic and Pharmacokinetic Effects of Ticagrelor in Patients With Diabetes Mellitus and Coronary Artery Disease

Author

Franchi, Francesco, Rollini, Fabiana, Been, Latonya, Maaliki, Naji, Abou Jaoude, Patrick, Rivas, Andrea, Zhou, Ricky, Jia, Sida, Briceno, Maryuri, Lee, Chang Hoon, Pineda, Andres, Suryadevara, Siva, Soffer, Daniel, Zenni, Martin, Bass, Theodore, and Angiolillo, Dominick J

Published
2020
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30. Aspirin-free strategies in cardiovascular disease and cardioembolic stroke prevention

Author

Capodanno, Davide, Mehran, Roxana, Valgimigli, Marco, Baber, Usman, Windecker, Stephan, Vranckx, Pascal, Dangas, George, Rollini, Fabiana, Kimura, Takeshi, Collet, Jean-Philippe, Gibson, C. Michael, Steg, Philippe Gabriel, Lopes, Renato D., Gwon, Hyeon-Cheol, Storey, Robert F., Franchi, Francesco, Bhatt, Deepak L., Serruys, Patrick W., and Angiolillo, Dominick J.

Published
2018
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31. Switching from dual antiplatelet therapy with aspirin plus a P2Y12 inhibitor to dual pathway inhibition with aspirin plus vascular-dose rivaroxaban

Author

Ortega-Paz, Luis, additional, Franchi, Francesco, additional, Rollini, Fabiana, additional, Galli, Mattia, additional, Been, Latonya, additional, Ghanem, Ghussan, additional, Shalhoub, Awss, additional, Ossi, Tiffany, additional, Rivas, Andrea, additional, Zhou, Xuan, additional, Pineda Maldonado, Andres M, additional, Suryadevara, Siva, additional, Soffer, Daniel, additional, Zenni, Martin M., additional, Jennings, Lisa K, additional, and Angiolillo, Dominick, additional

Published
2023
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33. IMPACT OF THE ABCD-GENE SCORE ON P2Y12 INHIBITOR CLINICAL EFFECTIVENESS AFTER PCI: A MULTI-SITE, REAL-WORLD INVESTIGATION

Author

Thomas, Cameron David, primary, Franchi, Francesco, additional, Keeley, Ellen, additional, Rossi, Joseph, additional, Anderson, R. David, additional, Gong, Yan, additional, Kerensky, Richard Alan, additional, McDonough, Caitrin, additional, Nguyen, Anh, additional, Winget, Marshall, additional, Duarte, Julio, additional, Beitelshees, Amber, additional, Johnson, Julie, additional, Stouffer, George A., additional, Winterstein, Almut, additional, Angiolillo, Dominick J., additional, Lee, Craig R., additional, and Cavallari, Larisa, additional

Published
2023
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37. Antithrombotic Issues in Women

Author

Muñiz-Lozano, Ana, Rollini, Fabiana, Franchi, Francesco, Cho, Jung Rae, Angiolillo, Dominick J., Mieszczanska, Hanna Z., editor, and Velarde, Gladys P., editor

Published
2014
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38. Platelet Inhibition With Cangrelor and Crushed Ticagrelor in Patients With ST-Segment–Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention: Results of the CANTIC Study

Author

Franchi, Francesco, Rollini, Fabiana, Rivas, Andrea, Wali, Mustafa, Briceno, Maryuri, Agarwal, Malhar, Shaikh, Zubair, Nawaz, Ahmed, Silva, Gabriel, Been, Latonya, Smairat, Ramez, Kaufman, Marc, Pineda, Andres M., Suryadevara, Siva, Soffer, Daniel, Zenni, Martin M., Bass, Theodore A., and Angiolillo, Dominick J.

Published
2019
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39. Factor XI inhibitors in early clinical trials: a meta-analysis

Author

Galli, Mattia, additional, Laborante, Renzo, additional, Ortega-Paz, Luis, additional, Franchi, Francesco, additional, Rollini, Fabiana, additional, D'Amario, Domenico, additional, Capodanno, Davide, additional, Tremoli, Elena, additional, Gibson, C. Michael, additional, Mehran, Roxana, additional, and Angiolillo, Dominick, additional

Published
2023
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40. Cangrelor in Patients With Coronary Artery Disease Pretreated With Ticagrelor

Author

Franchi, Francesco, primary, Ortega-Paz, Luis, additional, Rollini, Fabiana, additional, Galli, Mattia, additional, Been, Latonya, additional, Ghanem, Ghussan, additional, Shalhoub, Awss, additional, Ossi, Tiffany, additional, Rivas, Andrea, additional, Zhou, Xuan, additional, Pineda, Andres M., additional, Suryadevara, Siva, additional, Soffer, Daniel, additional, Zenni, Martin M., additional, Reiter, Birgit, additional, Jilma, Bernd, additional, and Angiolillo, Dominick J., additional

Published
2023
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41. Impact of Escalating Loading Dose Regimens of Ticagrelor in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention: Results of a Prospective Randomized Pharmacokinetic and Pharmacodynamic Investigation

Author

Franchi, Francesco, Rollini, Fabiana, Cho, Jung Rae, Bhatti, Mona, DeGroat, Christopher, Ferrante, Elisabetta, Dunn, Elizabeth C., Nanavati, Amit, Carraway, Edward, Suryadevara, Siva, Zenni, Martin M., Guzman, Luis A., Bass, Theodore A., and Angiolillo, Dominick J.

Published
2015
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43. 1157 WITCHING FROM DUAL ANTIPLATELET THERAPY WITH ASPIRIN PLUS A P2Y12 INHIBITOR TO DUAL PATHWAY INHIBITION WITH ASPIRIN PLUS VASCULAR-DOSE RIVAROXABAN: THE SWITCHING ANTI-PLATELET AND ANTI-COAGULANT THERAPY (SWAP-AC) STUDY

Author

Giordano, Salvatore, primary, Ortega-paz, Luis, additional, Franchi, Francesco, additional, Rollini, Fabiana, additional, Galli, Mattia, additional, Been, Latonya, additional, Ghanem, Ghussan, additional, Shalhoub, Awss, additional, Ossi, Tiffany, additional, Rivas, Andrea, additional, Zhou, Xuan, additional, Pineda, Andres M., additional, Suryadevara, Siva, additional, Soffer, Daniel, additional, Zenni, Martin M., additional, Jennings, Lisa K, additional, and Angiolillo, Dominick J., additional

Published
2022
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44. 1156 CANGRELOR IN PATIENTS WITH CORONARY ARTERY DISEASE PRE-TREATED WITH TICAGRELOR: THE SWITCHING ANTIPLATELET (SWAP)-5 STUDY

Author

Giordano, Salvatore, primary, Franchi, Francesco, additional, Ortega-paz, Luis, additional, Rollini, Fabiana, additional, Galli, Mattia, additional, Been, Latonya, additional, Ghanem, Ghussan, additional, Shalhoub, Awss, additional, Ossi, Tiffany, additional, Rivas, Andrea, additional, Zhou, Xuan, additional, Pineda, Andres M, additional, Suryadevara, Siva, additional, Soffer, Daniel, additional, Zenni, Martin M, additional, Reiter, Birgit, additional, Jilma, Bernd, additional, and Angiolillo, Dominick J, additional

Published
2022
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46. TCT-572 Impact of Evolocumab on the Pharmacodynamic Effects of Clopidogrel in Patients With Atherosclerotic Cardiovascular Disease: A Randomized, Double-Blind, Placebo-Controlled Study

Author

Ortega-Paz, Luis, primary, Rollini, Fabiana, additional, Been, Latonya, additional, Rivas, Andrea, additional, Maaliki, Naji, additional, Pineda, Andres, additional, Suryadevara, Siva, additional, Soffer, Daniel, additional, Zenni, Martin, additional, Angiolillo, Dominick, additional, and Franchi, Francesco, additional

Published
2022
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50. Pharmacodynamic Effects of Switching From Ticagrelor to Clopidogrel in Patients With Coronary Artery Disease: Results of the SWAP-4 Study

Author

Franchi, Francesco, Rollini, Fabiana, Rivas Rios, Jose, Rivas, Andrea, Agarwal, Malhar, Kureti, Megha, Nagaraju, Deepa, Wali, Mustafa, Shaikh, Zubair, Briceno, Maryuri, Nawaz, Ahmed, Moon, Jae Youn, Been, Latonya, Suryadevara, Siva, Soffer, Daniel, Zenni, Martin M., Bass, Theodore A., and Angiolillo, Dominick J.

Published
2018
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