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6. Effect of Rotavirus Infection and 2′-Fucosyllactose Administration on Rat Intestinal Gene Expression

Author

Sáez-Fuertes, Laura, Azagra-Boronat, Ignasi, Massot-Cladera, Malén, Knipping, Karen, Garssen, Johan, Franch, Àngels, Castell, Margarida, Pérez-Cano, Francisco J., Rodríguez-Lagunas, María J., Sáez-Fuertes, Laura, Azagra-Boronat, Ignasi, Massot-Cladera, Malén, Knipping, Karen, Garssen, Johan, Franch, Àngels, Castell, Margarida, Pérez-Cano, Francisco J., and Rodríguez-Lagunas, María J.

Abstract

Viral infections are described as modifying host gene expression; however, there is limited insight regarding rotavirus (RV) infections. This study aimed to assess the changes in intestinal gene expression after RV infection in a preclinical model, and the effect of 2-fucosyllactose (2′-FL) on this process. From days 2 to 8 of life, rats were supplemented with the dietary oligosaccharide 2′-FL or vehicle. In addition, an RV was inoculated on day 5 to nonsupplemented animals (RV group) and to 2′-FL-fed animals (RV+2′-FL group). Incidence and severity of diarrhea were established. A portion from the middle part of the small intestine was excised for gene expression analysis by microarray kit and qPCR. In nonsupplemented animals, RV-induced diarrhea upregulated host antiviral genes (e.g., Oas1a, Irf7, Ifi44, Isg15) and downregulated several genes involved in absorptive processes and intestinal maturation (e.g., Onecut2, and Ccl19). The 2′-FL-supplemented and infected animals had less diarrhea; however, their gene expression was affected in a similar way as the control-infected animals, with the exception of some immunity/maturation markers that were differentially expressed (e.g., Ccl12 and Afp). Overall, assessing the expression of these key genes may be useful in the evaluation of the efficacy of nutritional interventions or treatments for RV infection.

Published
2023

7. Effect of Rotavirus Infection and 2′-Fucosyllactose Administration on Rat Intestinal Gene Expression

Author

Afd Pharmacology, Pharmacology, Sáez-Fuertes, Laura, Azagra-Boronat, Ignasi, Massot-Cladera, Malén, Knipping, Karen, Garssen, Johan, Franch, Àngels, Castell, Margarida, Pérez-Cano, Francisco J., Rodríguez-Lagunas, María J., Afd Pharmacology, Pharmacology, Sáez-Fuertes, Laura, Azagra-Boronat, Ignasi, Massot-Cladera, Malén, Knipping, Karen, Garssen, Johan, Franch, Àngels, Castell, Margarida, Pérez-Cano, Francisco J., and Rodríguez-Lagunas, María J.

Published
2023

20. LEARNING REINFORCEMENT ACTIVITIES APPLIED TO THE SUBJECT PHYSIOLOGY AND PATHOPHYSIOLOGY III IN THE PHARMACY DEGREE OF THE UNIVERSITAT DE BARCELONA: THE OPINION OF THE STUDENTS

Author

Pelegrí, Carme, primary, Martin-Venegas, Raquel, additional, Del Valle, Jaume, additional, Franch, Àngels, additional, Juan, Maria Emília, additional, Miró, Lluisa, additional, Olloquequi, Jordi, additional, Vilaplana, Jordi, additional, and Ferrer, Rut, additional

Published
2022
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21. Molecular and in vivo studies of a glutamate-class prolyl-endopeptidase for coeliac disease therapy [Dataset]

Author

Amo-Maestro, Laura del, Mendes, Soraia R., Rodríguez-Banqueri, Arturo, Garzon-Flores, Laura, Girbal, Marina, Rodríguez-Lagunas, María José, Guevara, Tibisay, Franch, Àngels, Pérez-Cano, Francisco J., Eckhard, Ulrich, Gomis-Rüth, F. Xavier, Amo-Maestro, Laura del, Mendes, Soraia R., Rodríguez-Banqueri, Arturo, Garzon-Flores, Laura, Girbal, Marina, Rodríguez-Lagunas, María José, Guevara, Tibisay, Franch, Àngels, Pérez-Cano, Francisco J., Eckhard, Ulrich, and Gomis-Rüth, F. Xavier

Published
2022

22. Preventive Effect of a Postbiotic and Prebiotic Mixture in a Rat Model of Early Life Rotavirus Induced-Diarrhea

Author

Morales-Ferré, Carla, Azagra-Boronat, Ignasi, Massot-Cladera, Malén, Tims, Sebastian, Knipping, Karen, Garssen, Johan, Knol, Jan, Franch, Àngels, Castell, Margarida, Pérez-Cano, Francisco J., Rodríguez-Lagunas, María J., Morales-Ferré, Carla, Azagra-Boronat, Ignasi, Massot-Cladera, Malén, Tims, Sebastian, Knipping, Karen, Garssen, Johan, Knol, Jan, Franch, Àngels, Castell, Margarida, Pérez-Cano, Francisco J., and Rodríguez-Lagunas, María J.

Abstract

Rotavirus (RV) is the main cause of gastroenteritis in children. Prebiotics and, more recently, postbiotics are used for preventing and treating gastrointestinal infections. The aim of this study was to analyze the effects of a Lactofidus™, short-chain galacto-oligosaccharides (scGOS) and long-chain fructo-oligosaccharides (lcFOS) mixture, and their combination on RV infection, in a rat model, for early life diarrhea. Fifteen litters of suckling rats were intragastrically administered daily with the vehicle, the prebiotic mixture, the postbiotic or the combination. The RV was inoculated on day 5 and then fecal samples were clinically evaluated daily. Viral shedding, intestinal permeability assay, in vitro blocking assay, immunoglobulin profiles, and anti-RV response were assessed at day 8 and 16 of life. Cecal microbiota composition, intestinal gene expression, and short chain fatty acids (SCFAs) were analyzed at day 16. The incidence and severity of diarrhea were significantly reduced by all the supplementations. Moreover, they showed blocking activity, changes in the immunoglobulin profiles, in gut microbiota, and in the intestinal gene expression. The prebiotic mixture reduced gut permeability and changed the SCFA profile, whereas the postbiotic enhanced the expression of Toll-like receptors (TLRs). The combination preserved most of the individual observed effects, and furthermore, complementary effects, such as an increase in white blood cells and lymphocytes recruitment, as well as upregulation of TLR7 and TLR9 gene expression.

Published
2022

27. Preventive Effect of a Postbiotic and Prebiotic Mixture in a Rat Model of Early Life Rotavirus Induced-Diarrhea

Author

Morales-Ferré, Carla, primary, Azagra-Boronat, Ignasi, additional, Massot-Cladera, Malén, additional, Tims, Sebastian, additional, Knipping, Karen, additional, Garssen, Johan, additional, Knol, Jan, additional, Franch, Àngels, additional, Castell, Margarida, additional, Pérez-Cano, Francisco J., additional, and Rodríguez-Lagunas, María J., additional

Published
2022
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32. Detection and Prevention of Medication Errors by the Network of Sentinel Pharmacies in a Southern European Region.

Author

Jambrina, Anna M., Santomà, Àlex, Rocher, Andrea, Rams, Neus, Cereza, Glòria, Rius, Pilar, Gironès, Montserrat, Pareja, Clara, Franch, Àngels, and Rabanal, Manel

Subjects
MEDICATION error prevention, MEDICAL prescriptions, HEALTH services administration, DRUG side effects, BETA lactam antibiotics
Abstract

A medication error (ME) is a drug-related problem that has been recognized as a common and serious threat to patient safety. The aim of this study was to detect and analyze ME reports occurring throughout the therapeutic process through the community's pharmacies in order to improve the efficacy and safety of medications and contribute to the prevention of future MEs. This was a three-year descriptive, observational, and prospective study to detect and analyze the different MEs reported by the Catalan sentinel pharmacies network (Catalan SePhaNet). In total, 1394 notifications of MEs were reported (an incidence rate of 737.34 cases/100,000 inhabitants). MEs were detected more frequently in primary care centers. Most of the MEs reported were caused by an incorrect, incomplete, illegible, or verbal medical prescription (41.3%). Of the global notifications detected, 71.9% did not reach the patient (categories A and B). The drugs most frequently implicated in the reported ME cases were beta-lactam antibiotics. In 6.0% of the cases, the ME caused injury to the patient (categories E and F). In 72.0% of the global notifications, a pharmacist's intervention avoided the ME. The importance of a community pharmacy and the role of a pharmacist were demonstrated in aspects related to patient and drug safety. [ABSTRACT FROM AUTHOR]

Published
2023
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33. Rat Mucosal Immunity following an Intensive Chronic Training and an Exhausting Exercise: Effect of Hesperidin Supplementation.

Author

Ruiz-Iglesias, Patricia, Estruel-Amades, Sheila, Massot-Cladera, Malén, Franch, Àngels, Pérez-Cano, Francisco J., and Castell, Margarida

Abstract

Stressful situations such as a high-intensity exercise or exhausting training programs can act as immune disruptors leading to transitory immunodepression status, which can be accompanied by alterations of the gastrointestinal functions. Hesperidin intake has demonstrated ergogenic activity and is able to influence the intestinal ecosystem and immunity. We aimed to investigate the effect of hesperidin consumption in rats submitted to an intense training and a final exhaustion test, focusing on the functionality of the intestinal immune system and on the cecal microbiota. Rats, supplemented or not with hesperidin, were intensively trained on a treadmill for 5 weeks. Samples were obtained 24 h after a regular training session, and immediately and 24 h after a final exhaustion test. Cecal microbiota and composition and function of mesenteric lymph node (MLN) lymphocytes and mucosal immunoglobulin A (IgA) were determined. Results showed that chronic intense exercise followed by an exhausting test induced changes in the intestinal immune compartment such as the distribution and function of MLN lymphocytes. Although the hesperidin supplementation did not prevent these alterations, it was able to enhance IgA synthesis in the intestinal compartment. This could be important in enhancing the immune intestinal barrier in this stressful situation. [ABSTRACT FROM AUTHOR]

Published
2023
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34. Effects of a Postbiotic and Prebiotic Mixture on Suckling Rats' Microbiota and Immunity

Author

Morales-Ferré, Carla, Azagra-Boronat, Ignasi, Massot-Cladera, Malén, Tims, Sebastian, Knipping, Karen, Garssen, Johan, Knol, Jan, Franch, Àngels, Castell, Margarida, Rodríguez-Lagunas, María J, Pérez-Cano, Francisco J, Afd Pharmacology, Pharmacology, Afd Pharmacology, and Pharmacology

Subjects
Prebiòtics, Postbiotic, medicine.medical_treatment, Breastfeeding, Rats as laboratory animals, Prebiotic, Alletament, Lactofidus, Biology, Article, Immune system, Immunity, postbiotic, medicine, microbiota, Animals, TX341-641, MolEco, Food science, Receptor, Rates (Animals de laboratori), Feces, VLAG, Nutrition and Dietetics, Nutrition. Foods and food supply, Probiotics, ScGOS/lcFOS, Microbiota, Short-chain fatty acid, Cries d'animals, Young animals, SCFA, Gastrointestinal Microbiome, Rats, Prebiotics, Animals, Newborn, Infant formula, suckling rats, Suckling rats, Models, Animal, prebiotic, biology.protein, Antibody, Food Science, scGOS/lcFOS
Abstract

Human milk serves as a model for infant formula providing nutritional solutions for infants not able to receive enough mother's milk. Infant formulas aim to mimic the composition and functionality of human milk by providing ingredients reflecting those of the latest human milk insights, such as prebiotics, probiotics and postbiotics. The aim of this study was to examine the effects of the supplementation with a postbiotic (LactofidusTM) and its combination with the prebiotics short-chain galactooligosaccharides (scGOS) and long-chain fructooligosaccharides (lcFOS) in a preclinical model of healthy suckling rats. Pups were supplemented daily with LactofidusTM (POST group) and/or scGOS/lcFOS (P+P and PRE groups, respectively). Body weight and fecal consistency were analyzed. At the end of the study, immunoglobulin (Ig) profile, intestinal gene expression, microbiota composition and short chain fatty acid (SCFA) proportion were quantified. The supplementation with all nutritional interventions modulated the Ig profile, but the prebiotic mixture and the postbiotic induced differential effects: whereas scGOS/lcFOS induced softer feces and modulated microbiota composition and SCFA profile, Lactofidus upregulated Toll-like receptors gene expression. The use of the combination of scGOS/lcFOS and Lactofidus showed the effects observed for the oligosaccharides separately, as well as showing a synergistic impact on animal growth. Thus, the combined use of both products seems to be a good strategy to modulate immune and microbial features in early life. View Full-Text Keywords: postbiotic; prebiotic; suckling rats; Lactofidus; scGOS/lcFOS; microbiota; SCFA

Published
2021

37. SLIDE4U: CONSTRUCTION OF THE ONLINE CLASS THROUGH THE SLIDES EXPLAINED BY STUDENTS OF “HUMAN NUTRITION AND DIETETICS”

Author

Rodríguez-Lagunas, Maria José, primary, Azagra-Boronat, Ignasi, additional, Grases-Pintó, Blanca, additional, Ruíz-Iglesias, Patrícia, additional, Río-Aigé, Karla, additional, Franch, Àngels, additional, Castell, Margarida, additional, Izquierdo-Pulido, María, additional, Massot-Cladera, Malén, additional, and Pérez-Cano, Francisco, additional

Published
2021
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38. FROM FACE-TO-FACE TO ADAPTED ON-LINE CLASSES DUE TO COVID-19 PANDEMIC: COMPARISON OF THE EVALUATIVE RESULTS OF PHYSIOLOGY AND PATHOPHYSIOLOGY III OF THE PHARMACY DEGREE OF THE UNIVERSITAT DE BARCELONA

Author

Pelegrí, Carme, primary, Martín-Venegas, Raquel, additional, Franch, Àngels, additional, Miró, Lluïsa, additional, Massot-Cladera, Malen, additional, Juan, Maria Emília, additional, Vilaplana, Jordi, additional, and Ferrer, Rut, additional

Published
2021
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40. Effects of a Postbiotic and Prebiotic Mixture on Suckling Rats' Microbiota and Immunity

Author

Afd Pharmacology, Pharmacology, Morales-Ferré, Carla, Azagra-Boronat, Ignasi, Massot-Cladera, Malén, Tims, Sebastian, Knipping, Karen, Garssen, Johan, Knol, Jan, Franch, Àngels, Castell, Margarida, Rodríguez-Lagunas, María J, Pérez-Cano, Francisco J, Afd Pharmacology, Pharmacology, Morales-Ferré, Carla, Azagra-Boronat, Ignasi, Massot-Cladera, Malén, Tims, Sebastian, Knipping, Karen, Garssen, Johan, Knol, Jan, Franch, Àngels, Castell, Margarida, Rodríguez-Lagunas, María J, and Pérez-Cano, Francisco J

Published
2021

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