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5 results on '"Francesco Paolo De Rosa"'

1. How to Set Up Genetic Counselling for Inherited Macular Dystrophies: Focus on Genetic Characterization

Author

Raffaele Raimondi, Fabiana D’Esposito, Tania Sorrentino, Panos Tsoutsanis, Francesco Paolo De Rosa, Elisa Stradiotto, Gianmaria Barone, Angelica Rizzato, Davide Allegrini, Ciro Costagliola, and Mario R. Romano

Subjects
macular dystrophies, inherited retinal dystrophies, genetics, genetic testing, genotype/phenotype correlation, Biology (General), QH301-705.5, Chemistry, QD1-999
Abstract

Inherited macular dystrophies refer to a group of degenerative conditions that predominantly affect the macula in the spectrum of inherited retinal dystrophies. Recent trends indicate a clear need for genetic assessment services in tertiary referral hospitals. However, establishing such a service can be a complex task due to the diverse skills required and multiple professionals involved. This review aims to provide comprehensive guidelines to enhance the genetic characterization of patients and improve counselling efficacy by combining updated literature with our own experiences. Through this review, we hope to contribute to the establishment of state-of-the-art genetic counselling services for inherited macular dystrophies.

Published
2023
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2. Curcumin in Retinal Diseases: A Comprehensive Review from Bench to Bedside

Author

Davide Allegrini, Raffaele Raimondi, Alfredo Borgia, Tania Sorrentino, Giovanni Montesano, Panos Tsoutsanis, Giuseppe Cancian, Yash Verma, Francesco Paolo De Rosa, and Mario R. Romano

Subjects
curcumin, review, carrier, diabetic retinopathy, retinitis pigmentosa, macular degeneration, Biology (General), QH301-705.5, Chemistry, QD1-999
Abstract

Recent evidence in basic science is leading to a growing interest in the possible role of curcumin in treating retinal diseases. Curcumin has been demonstrated to be able to modulate gene transcription and reduce ganglion cell apoptosis, downgrade VEGF, modulate glucose levels and decrease vascular dysfunction. So far, the use of curcumin has been limited by poor bioavailability; to overcome this issue, different types of carriers have been used. Multiple recent studies disclosed the efficacy of using curcumin in treating different retinal conditions. The aim of this review is to comprehensively review and discuss the role of curcumin in retinal diseases from bench to bedside.

Published
2022
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3. Where Are We with RPE Replacement Therapy? A Translational Review from the Ophthalmologist Perspective

Author

Raffaele Raimondi, Piero Zollet, Francesco Paolo De Rosa, Panagiotis Tsoutsanis, Matteo Stravalaci, Marianna Paulis, Antonio Inforzato, and Mario R. Romano

Subjects
retinal pigmented epithelium, replacement, induced pluripotent stem cells, embryonic stem cells, age related macular degeneration, Stargardt disease, Biology (General), QH301-705.5, Chemistry, QD1-999
Abstract

The retinal pigmented epithelium (RPE) plays a pivotal role in retinal homeostasis. It is therefore an interesting target to fill the unmet medical need of different retinal diseases, including age-related macular degeneration and Stargardt disease. RPE replacement therapy may use different cellular sources: induced pluripotent stem cells or embryonic stem cells. Cells can be transferred as suspension on a patch with different surgical approaches. Results are promising although based on very limited samples. In this review, we summarize the current progress of RPE replacement and provide a comparative assessment of different published approaches which may become standard of care in the future.

Published
2022
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5. Trans-Scleral Plugs Fixated FIL SSF IOL: A Review of the Literature and Comparison with Other Secondary IOL Implants

Author

Raffaele Raimondi, Tania Sorrentino, Raphael Kilian, Yash Verma, Francesco Paolo De Rosa, Giuseppe Cancian, Panos Tsoutsanis, Giovanni Fossati, Davide Allegrini, and Mario R. Romano

Subjects
suture less fixation, secondary implant, Carlevale lens, scleral fixated intraocular lens, General Medicine
Abstract

Purpose. To revise the current literature on FIL SSF (Carlevale) intraocular lens, previously known as Carlevale lens, and to compare their outcomes with those from other secondary IOL implants. Methods. We performed a peer review of the literature regarding FIL SSF IOLs until April 2021 and analyzed the results only of articles with a minimum of 25 cases and a follow-up of at least 6 months. The searches yielded 36 citations, 11 of which were abstracts of meeting presentations that were not included in the analysis because of their limited data. The authors reviewed 25 abstracts and selected six articles of possible clinical relevance to review in full text. Of these, four were considered to be sufficiently clinically relevant. Particularly, we extrapolated data regarding the pre- and postoperative best corrected visual acuities (BCVA) and the complications related to the procedure. The complication rates were then compared with those from a recently published Ophthalmic Technology Assessment by the American Academy of Ophthalmology (AAO) on secondary IOL implants. Results. Four studies with a total of 333 cases were included for results analysis. The BCVA improved in all cases after surgery, as expected. Cystoid macular edema (CME) and increased intraocular pressure were the most common complications, with an incidence of up to 7.4% and 16.5%, respectively. Other IOL types from the AAO report included anterior chamber IOLs, iris fixation IOLs, sutured iris fixation IOLs, sutured scleral fixation IOLs, and sutureless scleral fixation IOLs. There was no statistically significant difference in the rates of postoperative CME (p = 0.20), and vitreous hemorrhage (p = 0.89) between other secondary implants and the FIL SSF IOL, whereas the rate of retinal detachment was significantly less with FIL SSF IOLs (p = 0.04). Conclusion. The results of our study suggest the implantation of FIL SSF IOLs is an effective and safe surgical strategy in cases where there is a lack of capsular support. In fact, their outcomes seem to be comparable to those obtained with the other available secondary IOL implants. According to published literature, the FIL SSF (Carlevale) IOL provides favorable functional results with a low rate of postoperative complications.

Published
2023

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