17 results on '"Francesca Di Pede"'
Search Results
2. Conceptual design of a biped-wheeled wearable machine for ALS patients
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Giovanni Gerardo Muscolo, Francesca Di Pede, Luca Solero, Angelo Nicolì, Alessandra Russo, Paolo Fiorini, Adriano Chiò, Andrea Calvo, and Antonio Canosa
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Exoskeleton ,Neurology ,Biped-Wheeled Wearable Machine, Exoskeleton, ALS ,Neurology (clinical) ,ALS ,Biped-Wheeled Wearable Machine - Published
- 2023
3. Use of brain 2-[18F]FDG-PET to discriminate ALS and ALS-mimics
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Antonio, Canosa, Martino, Alessio, Alessandro, Giuliani, Cristina, Moglia, Rosario, Vasta, Maurizio, Grassano, Sara, Cabras, Francesca Di Pede, Paolina, Salamone, Giulia, Marchese, Federico, Casale, Giulia, Polverari, Marco, Pagani, Umberto, Manera, Andrea, Calvo, and Adriano, Chiò
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- 2023
4. Exposure to electromagnetic fields does not modify neither the age of onset nor the disease progression in ALS patients
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Rosario Vasta, Stefano Callegaro, Maurizio Grassano, Antonio Canosa, Sara Cabras, Francesca Di Pede, Enrico Matteoni, Filippo De Mattei, Federico Casale, Paolina Salamone, Letizia Mazzini, Fabiola De Marchi, Cristina Moglia, Andrea Calvo, Adriano Chiò, and Umberto Manera
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electromagnetic fields ,Amyotrophic lateral sclerosis ,cross-sectional studies ,epidemiology ,prognosis ,Neurology ,Neurology (clinical) - Abstract
Being exposed to electromagnetic fields has been suggested to increase the risk of developing Amyotrophic Lateral Sclerosis (ALS). Here, we investigated the effect of exposure to electromagnetic fields on ALS onset age and progression rate (ΔALSFRS-r). A large cohort of ALS patients (n = 1098) was geolocalized at the time of their diagnosis. Concomitantly, data on the distribution of power lines and repeater antennas (extremely low frequency electromagnetic fields) during the same period were retrieved. Exposure to each repeater antenna was calculated as the sum of 1/(distance from each antenna)^2. Exposure to power lines was calculated assuming each patient's address as the center of several circles of variable radius (100, 250, 500, 1000, and 2000 m). For each radius, the exposure was calculated as the length of the power lines included in the circle. Finally, patients were divided into low- and high-exposed based on the median of the exposure and compared using the Mann-Whitney test. A regression model (one for each radius) was also performed. Neither the onset age nor the ΔALSFRS-r differed among patients' low- and high-exposed to electromagnetic fields. Similarly, we could not find any significant relationship using the regression models. Our findings suggest that electromagnetic fields do not modify the ALS phenotype or progression.
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- 2022
5. Brain metabolic differences between pure bulbar and pure spinal ALS: a 2-[
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Antonio, Canosa, Alessio, Martino, Alessandro, Giuliani, Cristina, Moglia, Rosario, Vasta, Maurizio, Grassano, Francesca, Palumbo, Sara, Cabras, Francesca, Di Pede, Filippo, De Mattei, Enrico, Matteoni, Giulia, Polverari, Umberto, Manera, Andrea, Calvo, Marco, Pagani, and Adriano, Chiò
- Abstract
MRI studies reported that ALS patients with bulbar and spinal onset showed focal cortical changes in corresponding regions of the motor homunculus. We evaluated the capability of brain 2-[We classified as pure bulbar (PB) patients with bulbar onset and a normal score in the spinal items of the ALSFRS-R, and as pure spinal (PS) patients with spinal onset and a normal score in the bulbar items at the time of PET. Forty healthy controls (HC) were enrolled. We compared PB and PS, and each patient group with HC. Metabolic clusters showing a statistically significant difference between PB and PS were tested to evaluate their accuracy in discriminating the two groups. We performed a leave-one-out cross-validation (LOOCV) over the entire dataset. Four classifiers were considered: support vector machines (SVM), K-nearest neighbours, linear classifier, and decision tree. Then, we used a separate test set, including 10% of patients, with the remaining 90% composing the training set.We included 63 PB, 271 PS, and 40 HC. PB showed a relative hypometabolism compared to PS in bilateral precentral gyrus in the regions of the motor cortex involved in the control of bulbar function. SVM showed the best performance, resulting in the lowest error rate in both LOOCV (4.19%) and test set (9.09 ± 2.02%).Our data support the concept of the focality of ALS onset and the use of 2-[
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- 2022
6. Role of brain 2-[
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Antonio, Canosa, Alessio, Martino, Umberto, Manera, Rosario, Vasta, Maurizio, Grassano, Francesca, Palumbo, Sara, Cabras, Francesca, Di Pede, Vincenzo, Arena, Cristina, Moglia, Alessandro, Giuliani, Andrea, Calvo, Adriano, Chiò, and Marco, Pagani
- Abstract
The identification of prognostic tools in amyotrophic lateral sclerosis (ALS) would improve the design of clinical trials, the management of patients, and life planning. We aimed to evaluate the accuracy of brain 2-[A prospective cohort study enrolled 418 ALS patients, who underwent brain 2-[Data were discretized in three survival profiles: 0-2 years, 2-5 years, and5 years. SVM resulted in an error rate20% for two out of three classes separately. As for class one, the discriminant clusters included left caudate body and anterior cingulate cortex. The most discriminant regions were bilateral cerebellar pyramid in class two, and right cerebellar dentate nucleus, and left cerebellar nodule in class three.Brain 2-[
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- 2022
7. Brain 18fluorodeoxyglucose-positron emission tomography changes in amyotrophic lateral sclerosis with TARDBP mutations
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Antonio Canosa, Andrea Calvo, Cristina Moglia, Rosario Vasta, Francesca Palumbo, Giuseppe Fuda, Francesca Di Pede, Sara Cabras, Vincenzo Arena, Andrea Novara, Paolina Salamone, Enrico Matteoni, Luca Sbaiz, Salvatore Gallone, Maurizio Grassano, Umberto Manera, Adriano Chiò, and Marco Pagani
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FUNCTIONAL IMAGING ,CEREBRAL METABOLISM ,Amyotrophic Lateral Sclerosis ,Brain ,NUCLEAR MEDICINE ,ALS ,PET ,Humans ,Mutation ,Positron-Emission Tomography ,Psychiatry and Mental health ,Surgery ,Neurology (clinical) - Published
- 2022
8. Brain metabolic differences between pure bulbar and pure spinal ALS: a 2-[18F]FDG-PET study
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Antonio Canosa, Alessio Martino, Alessandro Giuliani, Cristina Moglia, Rosario Vasta, Maurizio Grassano, Francesca Palumbo, Sara Cabras, Francesca Di Pede, Filippo De Mattei, Enrico Matteoni, Giulia Polverari, Umberto Manera, Andrea Calvo, Marco Pagani, and Adriano Chiò
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Positron emission tomography ,Neurology ,Neurology (clinical) ,Amyotrophic lateral sclerosis ,Amyotrophic lateral sclerosis, Positron emission tomography - Abstract
Background MRI studies reported that ALS patients with bulbar and spinal onset showed focal cortical changes in corresponding regions of the motor homunculus. We evaluated the capability of brain 2-[18F]FDG-PET to disclose the metabolic features characterizing patients with pure bulbar or spinal motor impairment. Methods We classified as pure bulbar (PB) patients with bulbar onset and a normal score in the spinal items of the ALSFRS-R, and as pure spinal (PS) patients with spinal onset and a normal score in the bulbar items at the time of PET. Forty healthy controls (HC) were enrolled. We compared PB and PS, and each patient group with HC. Metabolic clusters showing a statistically significant difference between PB and PS were tested to evaluate their accuracy in discriminating the two groups. We performed a leave-one-out cross-validation (LOOCV) over the entire dataset. Four classifiers were considered: support vector machines (SVM), K-nearest neighbours, linear classifier, and decision tree. Then, we used a separate test set, including 10% of patients, with the remaining 90% composing the training set. Results We included 63 PB, 271 PS, and 40 HC. PB showed a relative hypometabolism compared to PS in bilateral precentral gyrus in the regions of the motor cortex involved in the control of bulbar function. SVM showed the best performance, resulting in the lowest error rate in both LOOCV (4.19%) and test set (9.09 ± 2.02%). Conclusions Our data support the concept of the focality of ALS onset and the use of 2-[18F]FDG-PET as a biomarker for precision medicine-oriented clinical trials.
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- 2022
9. Amyotrophic Lateral Sclerosis with SOD1 mutations shows distinct brain metabolic changes
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Antonio Canosa, Andrea Calvo, Cristina Moglia, Rosario Vasta, Francesca Palumbo, Luca Solero, Francesca Di Pede, Sara Cabras, Vincenzo Arena, Grazia Zocco, Federico Casale, Maura Brunetti, Luca Sbaiz, Salvatore Gallone, Maurizio Grassano, Umberto Manera, Marco Pagani, and Adriano Chiò
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Amyotrophic Lateral Sclerosis ,Brain ,General Medicine ,SOD1 ,Brain metabolism ,18F-FDG-PET ,F-FDG-PET ,Superoxide Dismutase-1 ,Amyotrophic lateral sclerosis (ALS) ,Fluorodeoxyglucose F18 ,Mutation ,brain metabolism ,Humans ,Radiology, Nuclear Medicine and imaging ,Amyotrophic Lateral Sclerosis (ALS) - Abstract
Purpose Neuropathological data suggest that ALS with SOD1 mutations (SOD1-ALS) is a distinct form of ALS. We evaluated brain metabolic changes characterizing SOD1-ALS as compared to sporadic ALS (sALS), employing 18fluorodeoxyglucose-positron-emission tomography (18F-FDG-PET). Methods We included 18 SOD1-ALS patients, 40 healthy controls (HC), and 46 sALS patients without mutations in SOD1, TARDBP, FUS, and C9ORF72, randomly selected from 665 subjects who underwent brain 18F-FDG-PET at diagnosis between 2008 and 2019 at the ALS Centre of Turin. We excluded patients with frontotemporal dementia. We used the full factorial design in SPM12 to evaluate whether differences among groups exist overall. In case the hypothesis was confirmed, group comparisons were performed through the two-sample t-test model of SPM12. In all the analyses, the height threshold was P < 0.001 (P < 0.05 FWE-corrected at cluster level). Results The full factorial design resulted in a significant main effect of groups. We identified a relative hypometabolism in sALS patients compared to SOD1-ALS cases in the right precentral and medial frontal gyrus, right paracentral lobule, and bilateral postcentral gyrus. SOD1 patients showed a relative hypermetabolism as compared to HC in the right precentral gyrus and paracentral lobule. As compared to HC, sALS patients showed relative hypometabolism in frontal, temporal, and occipital cortices. Conclusion SOD1-ALS was characterized by a relative hypermetabolism in the motor cortex as compared to sALS and HC. Since promising, targeted, therapeutic strategies are upcoming for SOD1-ALS, our data support the use of PET to study disease pathogenesis and to track its course in clinical trials, in both asymptomatic and symptomatic mutation carriers.
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- 2022
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10. Telemedicine for patients with amyotrophic lateral sclerosis during COVID-19 pandemic: an Italian ALS referral center experience
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Adriano Chiò, Martina Arcari, Maria Claudia Torrieri, Rosario Vasta, Laura Peotta, Umberto Manera, Paolina Salamone, Margherita Daviddi, Francesca Palumbo, Fabrizio D'Ovidio, Antonio Canosa, Sara Cabras, Alessandro Bombaci, Giuseppe Fuda, Luca Solero, Barbara Iazzolino, Francesca Di Pede, Enza Mastro, Filippo De Mattei, Enrico Matteoni, Antonio Ilardi, Andrea Calvo, Silvia Giusiano, Maurizio Grassano, and Cristina Moglia
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Male ,Telemedicine ,motor neuron diseases ,Coronavirus disease 2019 (COVID-19) ,Clinical Neurology ,Speech Therapy ,Tertiary Care Centers ,03 medical and health sciences ,0302 clinical medicine ,Ambulatory care ,Pandemic ,medicine ,Humans ,Psychology ,remote consultation ,Amyotrophic lateral sclerosis ,COVID-19 ,telemedicine ,Aged ,Patient Care Team ,Remote Consultation ,SARS-CoV-2 ,business.industry ,Amyotrophic Lateral Sclerosis ,Disease Management ,Patient Preference ,Middle Aged ,medicine.disease ,Phone call ,Italy ,Neurology ,Patient Satisfaction ,Referral center ,Female ,Neurology (clinical) ,Medical emergency ,business ,030217 neurology & neurosurgery - Abstract
We describe the telemedicine experience of an Italian ALS tertiary Center during COVID-19 pandemic. A total of 144 visits were scheduled between 6th March and 6th April 2020. These mostly consisted of neurological or psychological visits (139, 96.5%). One hundred thirty-nine (96.5%) visits were performed as telemedicine and mostly via phone call (112, 80.6%). Three (2.1%) visits were considered as urgent and maintained as outpatient care. Additionally, patients were still able to telephone, being put through directly to their neurologists. Many requests of contact were addressed at getting information about the scheduled visits or examinations (45, 43.3%). Globally, patients and caregivers were satisfied with the telemedicine service. However, the majority (85, 65.9%) would prefer a face-to-face visit. In conclusion, telemedicine could be considered a good complement to face-to-face care, even after social restrictions have been eased.
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- 2020
11. Brain
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Antonio, Canosa, Andrea, Calvo, Cristina, Moglia, Rosario, Vasta, Francesca, Palumbo, Giuseppe, Fuda, Francesca, Di Pede, Sara, Cabras, Vincenzo, Arena, Andrea, Novara, Paolina, Salamone, Enrico, Matteoni, Luca, Sbaiz, Salvatore, Gallone, Maurizio, Grassano, Umberto, Manera, Adriano, Chiò, and Marco, Pagani
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Positron-Emission Tomography ,Amyotrophic Lateral Sclerosis ,Mutation ,Brain ,Humans - Published
- 2021
12. Do ecological factors influence the clinical presentation of amyotrophic lateral sclerosis?
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Antonio Canosa, Rosario Vasta, Sara Cabras, Fabiola De Marchi, Francesca Di Pede, Letizia Mazzini, Umberto Manera, Andrea Calvo, Adriano Chiò, and Cristina Moglia
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Male ,Pediatrics ,medicine.medical_specialty ,Disease ,Lower motor neuron ,03 medical and health sciences ,0302 clinical medicine ,neuroepidemiology ,medicine ,Humans ,Neuroepidemiology ,Amyotrophic lateral sclerosis ,Aged ,Retrospective Studies ,C9orf72 Protein ,Superoxide Dismutase ,business.industry ,Amyotrophic Lateral Sclerosis ,Spatial epidemiology ,Middle Aged ,medicine.disease ,motor neuron disease ,DNA-Binding Proteins ,Psychiatry and Mental health ,medicine.anatomical_structure ,Neurology ,Cohort ,Etiology ,RNA-Binding Protein FUS ,Female ,Surgery ,Body region ,Neurology (clinical) ,Age of onset ,business ,030217 neurology & neurosurgery - Abstract
Since its first description by Charcot, amyotrophic lateral sclerosis (ALS) has been classified as a single neurodegenerative disease involving motor neurons. More recently, however, it has become clear that ALS is pleiotropic and its phenotype could vary depending on several factors: age of onset, prevalent damage to the upper (UMN) or the lower motor neuron, body region mostly affected, progression rate and presence of non-motor symptoms, the most frequent being cognitive impairment.1 As a consequence, different phenotypes have been described.2 It remains unclear whether these presentations should be considered as distinct clinical entities or as variants of the same disease.3 More importantly, we do not know if different aetiologies justify this variability.3 Despite these uncertainties, we approach clinical trials by administering the same treatment to all patients with ALS.3 Spatial epidemiology could give some clues on aetiology by identifying clusters and subsequently seeking for causative genetic or environmental factors. Previously, we analysed the spatial distribution of a large ALS cohort in Northwestern Italy. Patients resulted to be homogeneously distributed, suggesting either that a single environmental factor was evenly distributed or that multiple factors acted on distinct subgroups, the latter being the more likely.4 Moving from the hypothesis that aetiology could vary according to phenotypes, here we performed a spatial analysis of ALS cases stratified according to their clinical presentation. Data from the Piemonte and Valle d’Aosta ALS Register were used.4 All patients with ALS diagnosed between 2007 and 2014 and who were resident in Piemonte at the time of diagnosis were included. The cluster analysis was conducted considering municipalities; …
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- 2021
13. Brain metabolic changes across King's stages in amyotrophic lateral sclerosis: a 18F-2-fluoro-2-deoxy-D-glucose-positron emission tomography study
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Vincenzo Arena, Philip Van Damme, Adriano Chiò, Marco Pagani, Davide Nardo, Koen Van Laere, Umberto Manera, Antonio Canosa, Rosario Vasta, Andrea Calvo, Sara Cabras, Fabrizio D'Ovidio, Francesca Di Pede, Cristina Moglia, Maurizio Grassano, Canosa, Antonio [0000-0001-5876-4079], Apollo - University of Cambridge Repository, Canosa, Antonio, Calvo, Andrea, Moglia, Cristina, Manera, Umberto, Vasta, Rosario, Di Pede, Francesca, Cabras, Sara, Nardo, Davide, Arena, Vincenzo, Grassano, Maurizio, D'Ovidio, Fabrizio, Van Laere, Koen, Van Damme, Philip, Pagani, Marco, and Chiò, Adriano
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King's staging system ,education ,030218 nuclear medicine & medical imaging ,18F-FDG-PET ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Fluorodeoxyglucose F18 ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Amyotrophic lateral sclerosis ,Stage (cooking) ,Amyotrophic lateral sclerosi ,Science & Technology ,medicine.diagnostic_test ,ABNORMALITIES ,business.industry ,Radiology, Nuclear Medicine & Medical Imaging ,Neurodegeneration ,Amyotrophic Lateral Sclerosis ,Brain ,General Medicine ,Anatomy ,Medial frontal gyrus ,medicine.disease ,F-FDG-PET ,King’s staging system ,medicine.anatomical_structure ,Glucose ,chemistry ,Positron emission tomography ,F-18-FDG-PET ,Positron-Emission Tomography ,Original Article ,Body region ,2-Deoxy-D-glucose ,business ,Life Sciences & Biomedicine ,030217 neurology & neurosurgery ,Motor cortex ,Human - Abstract
Purpose To assess the brain metabolic correlates of the different regional extent of ALS, evaluated with the King’s staging system, using brain 18F-2-fluoro-2-deoxy-d-glucose-PET (18F-FDG-PET). Methods Three hundred ninety ALS cases with King’s stages 1, 2, and 3 (n = 390), i.e., involvement of 1, 2, and 3 body regions respectively, underwent brain 18F-FDG-PET at diagnosis. King’s stage at PET was derived from ALSFRS-R and was regressed out against whole-brain metabolism in the whole sample. The full factorial design confirmed the hypothesis that differences among groups (King’s 1, King’s 2, King’s 3, and 40 healthy controls (HC)) existed overall. Comparisons among stages and between each group and HC were performed. We included age at PET and sex as covariates. Results Brain metabolism was inversely correlated with stage in medial frontal gyrus bilaterally, and right precentral and postcentral gyri. The full factorial design resulted in a significant main effect of groups. There was no significant difference between stages 1 and 2. Comparing stage 3 to stage 1+2, a significant relative hypometabolism was highlighted in the former in the left precentral and medial frontal gyri, and in the right medial frontal, postcentral, precentral, and middle frontal gyri. The comparisons between each group and HC showed the extension of frontal metabolic changes from stage 1 to stage 3, with the larger metabolic gap between stages 2 and 3. Conclusions Our findings support the hypothesis that in ALS, the propagation of neurodegeneration follows a corticofugal, regional ordered pattern, extending from the motor cortex to posterior and anterior regions.
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- 2021
14. Amyotrophic lateral sclerosis caregiver burden and patients��� quality of life during COVID-19 pandemic
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Paolina Salamone, Alessandro Bombaci, Cristina Moglia, Laura Peotta, Barbara Iazzolino, Giuseppe Fuda, Andrea Calvo, Silvia Giusiano, Francesca Palumbo, Adriano Chiò, Maria Claudia Torrieri, Martina Arcari, Rosario Vasta, Umberto Manera, Enrico Matteoni, Sara Cabras, Filippo DeMattei, Luca Solero, Francesca Di Pede, Enza Mastro, Maurizio Grassano, Antonio Canosa, and Margherita Daviddi
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medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,COVID-19 pandemic ,Caregiver Burden ,03 medical and health sciences ,Social support ,0302 clinical medicine ,Cost of Illness ,Quality of life ,Surveys and Questionnaires ,Pandemic ,Humans ,Medicine ,Amyotrophic lateral sclerosis ,Pandemics ,ALS ,caregiver burden ,QOL ,SARS-CoV-2 ,business.industry ,Amyotrophic Lateral Sclerosis ,COVID-19 ,Caregiver burden ,medicine.disease ,humanities ,Caregivers ,Neurology ,Communicable Disease Control ,Cohort ,Quality of Life ,Physical therapy ,Neurology (clinical) ,General health ,business ,030217 neurology & neurosurgery - Abstract
Objective: To assess patients Quality of life (QoL) and the burden of their caregivers during Covid-19 pandemic and specifically the impact of two-month lockdown period. Methods: In April 2020, a total of 60 patients and 59 caregivers were administered by phone scales assessing patients��� QoL (McGill QoL Questionnaire), general health status (EQ-5D-5L), and caregiver burden (Zarit Burden Interview). The administration was repeated one month after the end of lockdown measures, with the addition of a qualitative questionnaire (COVID-QoL Questionnaire) exploring family reorganization and personal perception of lock down. Results: QoL and perceived health status did not worsen during lockdown, while caregiver burden increased (p = 0.01). Patient���s QoL and caregiver burden were inversely correlated at T1 (ZBI total score mildly correlated with Mc Gill existential subscore, p = 0.02, rho = 0.30 and with Mc Gill total score, p = 0.05, rho = 0.265). No significant correlations were found at T2. According to the COVID-QoL questionnaire, caregivers perceived lower family help compared to patients (p Conclusions: Restricted measures of lockdown period during COVID-19 pandemic did not result in a significant reduction of QoL in our cohort of ALS patients, while caregiver burden significantly increased. ALS motor impairment may have played a role in the unchanged life conditions of patients. Instead, the restriction of family help for primary caregivers could be responsible of their increased burden, reflecting the importance of a wide social support in the management of this clinical condition.
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- 2021
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15. The interplay among education, brain metabolism, and cognitive impairment suggests a role of cognitive reserve in Amyotrophic Lateral Sclerosis
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Andrea Calvo, Antonio Canosa, Maurizio Grassano, Rosario Vasta, Umberto Manera, Adriano Chiò, Francesca Palumbo, Luca Solero, Laura Peotta, Francesca Di Pede, Vincenzo Arena, Marco Pagani, Barbara Iazzolino, and Cristina Moglia
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0301 basic medicine ,Male ,Aging ,Cerebellum ,F-FDG-PET ,Amyotrophic lateral sclerosis ,Cognitive reserve ,Frontotemporal dementia ,Brain damage ,03 medical and health sciences ,0302 clinical medicine ,Cognitive Reserve ,Fluorodeoxyglucose F18 ,medicine ,Humans ,Cognitive Dysfunction ,business.industry ,General Neuroscience ,Amyotrophic Lateral Sclerosis ,Brain ,Cognition ,Medial frontal gyrus ,medicine.disease ,Frontotemporal Dementia ,18F-FDG-PET ,Pons ,030104 developmental biology ,medicine.anatomical_structure ,Positron-Emission Tomography ,Educational Status ,Brain Damage, Chronic ,Female ,Neurology (clinical) ,Geriatrics and Gerontology ,medicine.symptom ,Radiopharmaceuticals ,business ,Neuroscience ,030217 neurology & neurosurgery ,Developmental Biology - Abstract
We tested the Cognitive Reserve (CR) hypothesis in Amyotrophic Lateral Sclerosis (ALS), enrolling 111 patients, using education as CR proxy, 18F-FDG-PET to assess brain damage, and ECAS to measure cognition. Education was regressed out against brain metabolism, including age, sex, spinal/bulbar onset, ALSFRS-R, and ECAS as covariates. Clusters showing a significant correlation were used as seed regions in an interregional correlation analysis (IRCA) in the ALS group and in 40 controls. In the ALS group, we found a negative correlation between brain metabolism and education in the right anterior cingulate and bilateral medial frontal gyrus. In the IRCA in the ALS group, the medial frontal cluster metabolism positively correlated with that of frontotemporal regions (right > left), bilateral caudate nuclei, and right insula, and negatively correlated with that of corticospinal tracts, cerebellum, and pons. In controls, the IRCA showed significant positive correlations in the same regions but less extended. Our results agree with the CR hypothesis. The negative correlation between the medial frontal cluster and the cerebellum found only in ALS patients might reflect cerebellar compensation.
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- 2020
16. Brain 18F-FDG-PET signature of ALS with SOD1 and TARDBP mutations
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Marco Pagani, Antonio Canosa, Cristina Moglia, Maura Brunetti, Umberto Manera, Francesca Di Pede, Maurizio Grassano, Andrea Calvo, Rosario Vasta, and Adriano Chiò
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Neurology ,business.industry ,SOD1 ,Cancer research ,Medicine ,Neurology (clinical) ,business ,TARDBP ,Signature (logic) ,18f fdg pet - Published
- 2021
17. HMSN-P associated with TFG P.PRO285LEU variant in an Italian family
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Adriano Chiò, Sara Cabras, Antonio Canosa, Salvatore Gallone, Andrea Calvo, Francesca Di Pede, and Cristina Moglia
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Neurology ,Neurology (clinical) - Published
- 2021
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