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1. Inter-observer agreement of tumor infiltrating lymphocytes in primary HER2-positive breast cancer and correlation between tissue microarray and full tumor-sections

Author

Frances Mary Reznitsky, Jeanette Dupont Jensen, Ann Knoop, and Anne‐Vibeke Laenkholm

Subjects
Microbiology (medical), Observer Variation, full-sections, inter-observer agreement, Receptor, ErbB-2, Breast Neoplasms, General Medicine, Prognosis, Pathology and Forensic Medicine, Pathologists, Lymphocytes, Tumor-Infiltrating, tumor infiltrating lymphocytes, Biomarkers, Tumor, Tumor Microenvironment, Immunology and Allergy, Humans, Female, TMA, HER2-positive breast cancer
Abstract

Tumor infiltrating lymphocytes (TILs) have predictive and prognostic potential in HER2-positive breast cancer (HER2 + BC). Due to tumor heterogeneity, guidelines recommend evaluation on full tumor-sections over biopsies, but aren't clear regarding tissue microarrays (TMAs). Herein, we investigate the inter-observer agreement of TILs assessment in HER2 + BC on full-sections and TMAs using a standardized method. Two pathologists assessed TILs using HE full-sections and TMAs from 244 patients with HER2 + BC. TILs were assessed in 10% intervals; values

Published
2022

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