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A new in situ monitoring strategy is proposed to study void formation during real-time impregnation of dual-scale fibrous reinforcements in liquid composite molding. Void content data from burn-off tests are used to calibrate a refractive index matching approach based on two optical principles: Beer–Lambert and Fresnel laws. Once calibrated, this approach based on visible light transmission is used to study the impact of key process parameters on the saturation footprint of dual-scale fibrous reinforcements during and after mold filling. The injection parameters investigated are the flow front velocity, the pressure distribution inside the mold cavity, the bleeding flow rate, and the mold packing pressure. The experimental setup is a computer-assisted injection system and a transparent resin transfer molding mold is used to perform unidirectional injections. A vinyl ester resin is injected through E-glass bidirectional non-crimp fabrics under various manufacturing conditions. This investigation not only confirms the decreasing trend in void formation by mechanical entrapment of air with the decrease in impregnation velocity, as it converges toward the optimal impregnation conditions for this fibrous reinforcement reported in previous studies, but it also brings insights on void dissolution and transport in liquid composite molding.

A crucial step in many composites manufacturing processes is the impregnation of fibrous medium with the resin. The fundamental property needed to quantify the flow is the permeability of the fibrous medium. Process models require the permeability as input data to predict flow patterns and pressure fields. Image-based computation can offer a good alternative to provide input data for subsequent analysis. However, digital images contain a huge amount of information that is difficult to handle in numerical models. Then efficient numerical techniques are needed to solve homogenization problems with geometrical data coming from high-resolution images, involving two or three scales and linear and non-linear fluids. Within this framework, this work addresses three main questions: (i) how to define an equivalent macroscopic Darcy’s model from a microscopic description consisting of a viscous fluid flow model defined in a two and three scales porous medium?; (ii) the discussion on the existence of an intrinsic geometrical permeability tensor in the general case of non Newtonian rheothining fluid models, and (iii) the proposal of a constructive multi-scale strategy for performing micro-macro simulations in both the linear and the nonlinear case.

Image-based simulation is being considered more and more in industrial applications, where more than simulate the expected reality it seems preferable to simulate the reality itself. For example, in heterogeneous composite materials more than assuming a particular distribution of the material constituents, it is preferable to solve the model in the real distribution, the one existing in the considered material that is accessible from an appropriate scanning technique. However such route requires, in many applications, advanced simulation techniques able to proceed in real time, looking for a synchronism with the scanning process itself. This constitutes a challenging issue due to the rate of image acquisition and the amount of information associated to each one. This work proposes an efficient strategy for solving thermal problems in two scales heterogeneous media in both the linear and the nonlinear case. In both cases the calculation of the homogenized thermal conductivity tensor requires the solution of many thermal problems defined at the microstructure level, here considered coming from digital images. For alleviating the computational cost and speeding up calculations to fulfill real time constraints, we propose an offline/online procedure for evaluating the homogenized thermal conductivities.

International audience; Composites manufacturing processes usually involve multiscale models in both space and time, highly non-linear and anisotropic behaviors, strongly coupled multiphysics and complex geometries. In this framework, the use of simulation for real-time decision making directly in the manufacturing facility is still precluded nowadays, in spite of the impressive progresses reached in numerical analysis and computer science during the last decade. In this paper, a process-specific simulation tool based on reduced order modeling is introduced, the Simulation App. This concept is presented through a practical case involving a multi-physics and coupled problem describing the manufacturing process of a composite outlet guide vane. We show that several manufacturing settings can be simulated in few seconds with the Simulation App, thus enabling fast process optimization. Finally, the advantages over general-purpose simulation software, in the context of process simulation, are discussed.

Liquid composite molding (LCM) is an increasingly used family of processes to manufacture composite parts. In LCM, the fibrous reinforcement is first laid in a mold cavity. After closure of the mold or covering of the reinforcement with a plastic bag, a liquid polymer resin is injected or infused under vacuum through the fiber bed. A key issue and novel feature of this investigation lies in the dual-scale architecture of engineering fabrics: microscopic pores exist between the filaments of the fiber tows, while macroscopic pores are created between the tows as a result of the stitching/weaving process. On a microscopic scale, capillary flows in fiber tows and gaps between tows play a major role on the quality of impregnation of the fiber bed by the liquid resin. In order to better understand the mechanisms that govern the impregnation of fibrous reinforcements in LCM, an experimental study of wicking behavior was carried out based on capillary rise experiments. A new monitoring technique based on fluorescent dye penetration inspection (DPI) and digital imaging was implemented in this investigation to track the capillary flow front. Visual monitoring of the capillary front is coupled with Wilhelmy’s approach based on real-time fluid mass acquisition with a high resolution balance. Experimental observations of the height of the capillary front and the uptake fluid mass absorbed by the fabric were analyzed by two different imbibition models.

This paper addresses the numerical simulation of void formation and transport during mold filling in Resin Transfer Molding (RTM). The saturation equation, based on a two-phase flow model resin/air, is coupled with Darcy s law and mass conservation to simulate the unsaturated filling flow that takes place in a RTM mold when resin is injected through the fiber bed. These equations lead to a system composed of an advection diffusion equation for saturation including capillary effects and an elliptic equation for pressure taking into account the effect of air residual saturation. The model introduces the relative permeability as a function of resin saturation. When capillary effects are omitted, the hyperbolic nature of the saturation equation and its strong coupling with Darcy equation through relative permeability represent a challenging numerical issue. The combination of the constitutive physical laws relating permeability to saturation with the coupled system of the pressure and saturation equations allows predicting the saturation profiles. The model was validated by comparison with experimental data obtained for a fiberglass reinforcement injected in a RTM mold at constant flow rate. The saturation measured as a function of time during the resin impregnation of the fiber bed compared very well with numerical predictions., The authors acknowledge financial support of the Spanish Government (Projects DPI2010-20333 and DPI2013-44903-R-AR), of the National Science and Research Council of Canada (NSERC) and of the Canada Reseach Chair (CRC) program.

Liquid Composite Molding (LCM) is an increasingly used class of processes to manufacture high performance composites. Engineering fabrics commonly used in LCM generally have a dual scale architecture in terms of porosity: microscopic pores exist between the filaments in the fiber tows, while macroscopic pores appear between the tows. Capillary flows in fiber tows play a major role on the quality of composites made by resin injection through fibrous reinforcements. This paper reports on an investigation on fabric imbibition characterization and subsequent evaluation of the optimal flow front velocity during resin injection through fibrous reinforcements. The goal is to devise more robust LCM processes and improve part quality. In order to evaluate a priori the injection conditions that minimize void formation, an impregnation model is developed based on imbibition characterization. This approach allows predicting the optimal front velocity without having to model complex dual scale flows through fibrous reinforcements and without performing expensive and time-consuming fabrication tests. After a summary of previous imbibition results obtained with a probe fluid, the optimal modified capillary numbers are computed by the new predictive model and the values are compared with results reported in the literature on void formation in LCM processes. Afterwards, capillary rise measurements are carried out with four infiltration fluids in order to evaluate the range of optimal flow front velocity that minimizes void formation. This characterization is implemented with vinyl ester resin, epoxy anhydride resin, styrene and anhydride. Finally, the optimal flow front velocity is evaluated for several fabric configurations.

Sport hunting may help in controlling cervid populations over large areas. As with natural predators, several environmental factors can influence sport harvest. A better understanding of the environmental variables that limit the efficiency of sport hunting could provide guidelines for more efficient wildlife management using hunting. We studied white-tailed deer (Odocoileus virginianus) hunting on a high deer density island where hunting was the sole form of predation. Our objective was to study the behavior of sport hunters and determine the habitat characteristics (e.g., abundance of deer forage, visibility of the deer from the hunter's point of view, and accessibility of the territory to hunters) that are associated with a successful harvest. We collected movements and harvest site location data from 477 hunters equipped with handheld Global Positioning System (GPS) units. Harvest sites were visited and characterized, along with a paired random site, to determine the environmental conditions associated with a successful hunt. We also developed a model to predict the daily number of deer seen by hunters considering weather conditions, hunter characteristics (e.g., age, experience), and date of hunting. We used the mean number of deer seen per hunter per day as a relative index of local density in each hunted territory. At both the site and landscape scales, the combination of visibility and access had a positive effect on the distribution of harvested deer. Habitat types with less visual obstruction from vegetation enabled hunters to see more deer in a given day. At the site scale, harvested deer were located in areas with a lower density of access routes compared to areas where hunters travelled throughout the day. Using an innovative approach of studying hunter behavior with GPS technology, digital maps, and questionnaires, we highlighted the factors associated with hunter success. Our study suggests that habitat characteristics could be modified to increase harvest by improving accessibility and visibility near roads. Creating openings in mature and regenerating forest near access roads could make sport hunting a more efficient management tool, but the potential impact of increased forage availability in forest openings should not be overlooked. © 2012 The Wildlife Society.

Liquid Composite Molding (LCM) is an increasingly used class of processes to manufacture high performance composites. In LCM, the fibrous reinforcement is first laid in a mold cavity. After closure of the mold or covering of reinforcement with a plastic bag, a polymer resin is either injected or infused under vacuum through the fiber bed. The engineering fabrics commonly used in LCM possess generally dual scale architecture in terms of porosity: microscopic pores exist between the filaments in the fiber tows, while macroscopic pores appear between the tows as a result of the stitching/weaving fabrication process. On a microscopic scale, capillary flows in fiber tows play a major role on the quality of composites made by resin injection through fibrous reinforcements. In order to better understand the mechanisms that govern the impregnation of fibrous reinforcements in LCM, a study of wicking behavior is carried out in fiber tows. The experimental approach is based on capillary rise experiments, which are less expensive and time-consuming than other more standard characterization techniques often used in porous media. In addition, it allows gathering representative data on the wicking properties of fiber tows as a function of their morphological characteristics such as micro-porosity, total cross-section area, specific surface area, filament diameter and packing configuration. The morphological properties of the fiber tows will also be characterized by other standard experimental methods in order to compare with the results obtained by capillary rise experiments. These standard methods include gravimetry for the micro-porosity and fiber mass density, microscopic analysis to measure the filament diameter, cross-section area and packing configuration of the filaments and capillary flow porometry to evaluate the equivalent pore diameter. The capillary rise method has already been used not only in Soil Mechanics, but also to characterize engineering textiles used in high performance composites. Such experiments are not easy to perform, because of technical difficulties such as textile geometrical alteration during testing, changes in fluid properties due to solvent evaporation and inaccurate observation of the progression of the capillary front (fading). To circumvent these problems, a monitoring technique based on fluorescent dye penetration inspection (DPI) and CCD image acquisition is proposed in this investigation. Visual monitoring of the capillary front is coupled with real-time fluid mass acquisition using a high resolution balance. Experimental observations on the height of the capillary front and the fluid mass absorbed by the fiber tows can be analyzed by four imbibition models. These models consider the evolution of the capillary height with (model I) or without gravity (model II) and of the fluid mass absorbed by capillary effect with (model III) or without gravity (model IV). The models without gravity will be used on short imbibition distances to derive the microscopic properties of fiber tows from the experimentally observed evolutions of the capillary height and the fluid mass absorbed by capillarity. After describing the new capillary rise setup devised for the fiber tow experiments, a set of experiments is carried out to characterize the properties of the fiber tows and investigate the wicking phenomena along the warp and weft directions. The consistency of this approach is compared with more standard methods. At the same time, the impact of fiber sizing on the tow wicking behavior is investigated. Note that experimental evaluations of tow permeability can also be derived from this approach. The results compare well with permeability predictions based on Blake-Kozeny-Carman models. In the future, it will be possible to apply the same experimental approach to engineering fabrics. Indeed, a comprehensive wicking characterization of fibrous reinforcements is expected to provide useful information in order to evaluate the optimal processing conditions of high performance composites fabricated by Liquid Composite Molding.

This paper presents a fractional flow model based on two-phase flow, resin and air, through a porous medium to simulate numerically Liquid Composites Molding (LCM) processes. It allows predicting the formation, transport and compression of voids in the modeling of LCM. The equations are derived by combining Darcy’s law and mass conservation for each phase (resin/air). In the model, the relative permeability and capillary pressure depend on saturation. The resin is incompressible and the air slightly compressible. Introducing some simplifications, the fractional flow model consists of a saturation equation coupled with a pressure/velocity equation including the effects of air solubility and compressibility. The introduction of air compressibility in the pressure equation allows for the numerical prediction of the experimental behavior at low constant resin injection flow rate. A good agreement was obtained between the numerical prediction of saturation in a glass fiber reinforcement and the experimental observations during the filling of a test mold by Resin Transfer Molding (RTM). 2015 Elsevier Ltd. All rights reserved., The authors acknowledge financial support of the Spanish Government (Project DPI2013-44903-R-AR).

One hundred twenty cystic fibrosis patients were accepted for transplantation. Twenty-five patients underwent double-lung transplantation. Twenty-five patients died awaiting transplantation (20.6%). There were 13 female and 12 male patients. Their mean age was 28 years (range, 7 to 34 years), and mean percentage ideal body weight was 76% (range, 58.5% to 91.9%). Most patients were hypoxic and hypercarbic. Two patients underwent tracheal anastomosis, 15 had en bloc bronchial anastomoses, and 8 had sequential single-lung transplants. Operative mortality was 16%; all deaths were related to bleeding from extensive adhesions. Actuarial survival at 1 year was 64%. Rejection and infection were frequent during the first month and decreased thereafter. Airway complications occurred in 5 patients but were amenable to laser therapy and stenting. We conclude that double-lung transplantation is an acceptable modality for the treatment of cystic fibrosis patients with end-stage lung disease. It may be a better alternative to heart-lung transplantation considering the paucity of thoracic organ donors.

A 37-year-old woman with a cadaveric renal allotransplantation required intra-cranial shunting devices after a presumptive episode of tuberculous meningitis. Six months later, she developed a culture-proven cryptococcal meningitis. Without having her ventriculo-auricular shunt removed, she was successfully treated with a short course of amphotericin B (335 mg) and flucytosine (nine days) followed by prolonged therapy with oral fluconazole (400 mg daily for 72 days). Three years post treatment she had no evidence of relapse, and normal renal graft function.

The term interferon (IFN) was first used by Isaacs and Lindenmann in 1957 to describe a factor, present in the supernatant of cultured chick chorioallantoic membranes previously injected with heat-inactivated influenza virus, that could render fresh chick membranes resistant to challenge with live virus. Since that time, studies performed in many laboratories have not only confirmed this phenomenon, but have greatly expanded our understanding of the IFN family of proteins and their role in viral infections. Moreover, a number of clinical trials have suggested that IFNs may be of use in the prophylaxis and therapy of herpesvirus infections. We will discuss the role of IFNs in the biological response to herpesviruses and review the trials addressing their clinical utility.