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Submitted by Gerson Neto (gerson_neto@hotmail.it) on 2019-11-13T15:21:11Z No. of bitstreams: 4 Dissertacao GERSON NETO.pdf: 2554070 bytes, checksum: 168c6b26aa7c3df200dda5d88ffeb73e (MD5) CCI13112019_00002.pdf: 404614 bytes, checksum: f032839732072b4242066de32c06da38 (MD5) Ata Defesa Gerson.pdf: 207593 bytes, checksum: b52e051cc80ee5dc98defffddb515a7c (MD5) Ficha Catalogr??fica.pdf: 1964 bytes, checksum: 48aa10787c16c50594f3fa8144c525f4 (MD5) Rejected by PPGO ODONTOLOGIA (ppgo@ufam.edu.br), reason: Vossa Senhoria, A ficha catalogr??fica deve constar no teor da pr??pria disserta????o, motivo por que se indefere o dep??sito e recomenda-se retifica????o. Atenciosamente, on 2019-11-18T14:17:25Z (GMT) Submitted by Gerson Neto (gerson_neto@hotmail.it) on 2019-11-18T15:12:38Z No. of bitstreams: 3 CCI13112019_00002.pdf: 404614 bytes, checksum: f032839732072b4242066de32c06da38 (MD5) Ata Defesa Gerson.pdf: 207593 bytes, checksum: b52e051cc80ee5dc98defffddb515a7c (MD5) Disserta????o Final Gerson.pdf: 2644159 bytes, checksum: d785446d340590b9743f55240b4a0345 (MD5) Approved for entry into archive by PPGO ODONTOLOGIA (ppgo@ufam.edu.br) on 2019-11-18T15:24:26Z (GMT) No. of bitstreams: 3 CCI13112019_00002.pdf: 404614 bytes, checksum: f032839732072b4242066de32c06da38 (MD5) Ata Defesa Gerson.pdf: 207593 bytes, checksum: b52e051cc80ee5dc98defffddb515a7c (MD5) Disserta????o Final Gerson.pdf: 2644159 bytes, checksum: d785446d340590b9743f55240b4a0345 (MD5) Approved for entry into archive by Divis??o de Documenta????o/BC Biblioteca Central (ddbc@ufam.edu.br) on 2019-11-18T18:26:26Z (GMT) No. of bitstreams: 3 CCI13112019_00002.pdf: 404614 bytes, checksum: f032839732072b4242066de32c06da38 (MD5) Ata Defesa Gerson.pdf: 207593 bytes, checksum: b52e051cc80ee5dc98defffddb515a7c (MD5) Disserta????o Final Gerson.pdf: 2644159 bytes, checksum: d785446d340590b9743f55240b4a0345 (MD5) Made available in DSpace on 2019-11-18T18:26:26Z (GMT). No. of bitstreams: 3 CCI13112019_00002.pdf: 404614 bytes, checksum: f032839732072b4242066de32c06da38 (MD5) Ata Defesa Gerson.pdf: 207593 bytes, checksum: b52e051cc80ee5dc98defffddb515a7c (MD5) Disserta????o Final Gerson.pdf: 2644159 bytes, checksum: d785446d340590b9743f55240b4a0345 (MD5) Previous issue date: 2018-02-28 FAPEAM - Funda????o de Amparo ?? Pesquisa do Estado do Amazonas 92996126902 Among all the malignant neoplasms in childhood, lymphoblastic leukemia (ALL) is the most common, with its B cell type (ALL-B) being the most frequent. Its diagnosis is based on, among other aspects, the observation of hematological indices from the peripheral blood smear test. Besides calling for the possible presence of a malignancy, help to support the treatment, which involves chemotherapy protocol. In Brazil, the most used is the one purposed by the Grupo Brasileiro de Tratamento da Leucemia na Inf??ncia (GBTLI-2009), but the treatment causes secondary complications, such nausea, emesis, baldness, fatigue, diarrhea, besides oral impairments, specially oral mucositis. Systemic toxicity can jeopardize hematopoiesis, thus, altering patients??? hematological indices, leading to immunosuppression with or without myelosuppression. This study evaluated the incidence of oral impairments and hematological indices pediatric patients diagnosed with ALL-B, in treatment at Funda????o de Hematologia e Hemoterapia do Amazonas (HEMOAM), according to GBTLI LLA-2009 protocol. The patients were submitted to intraoral screenings for oral impairments, plus evaluation of their hematological indices thru prophase and induction chemotherapy. The data analysis was performed by Mann Whitney and Fisher???s exact test, with p ??? 0,05. Within the 21 patients evaluated, 57,14% (n=12) were males, with age???s mean being 5 years-old. The majority of patients was categorized as being in the low relapse risk group (80,96%; n= 17). Regarding the oral impairments classically related to and/or seen during chemotherapy to ALL, 28,57% (n=6) of the patients presented some sort of those impairments, specially oral mucositis. On the other side, 61,90% (n=13) of the patients presented non-specific oral impairments, with the most prevalent one being dental caries, with 71,42% (n=15). Most of the patients presented leukocytosis at diagnose, which was followed by leukopenia thru prephasis and induction of chemotherapy, with similar drop in the lymphocyte, neutrophils and blsts, with no statistical differences among other hematological indices. No relation was found between oral impaiments and hematological indexes at any moment of prephasis and induction of chemotherapy by the GBTLI LLA-2009 protocol. So, the conclusions were that the incidence of oral impairments in ALL-B patients treated at HEMOAM is very low, apparently with no relationship with the hematological indexes found on those patients. On the other side, this low prevalence of oral impairments may be because of the dentist inserted in the multidisciplinary team treating the ALL patients, treating the oral impairments that show up during the chemotherapy. Dentre as neoplasias malignas prevalentes na inf??ncia, a leucemia linf??ide aguda (LLA) tamb??m chamada de leucemia linfobl??stica ?? a mais comum, sendo a LLA de c??lulas B (LLA-B) seu subtipo mais frequente. Seu diagn??stico envolve, al??m de outros aspectos, a observa????o dos ??ndices hematol??gicos provenientes do hemograma. Estes ??ndices, al??m de sinalizarem a possibilidade da presen??a da doen??a, ajudam a nortear seu tratamento, o qual envolve a ado????o de um protocolo quimioter??pico. No Brasil, o mais adotado ?? o proposto pelo Grupo Brasileiro de Tratamento da Leucemia na Inf??ncia (GBTLI-2009), por??m tal tratamento pode gerar complica????es secund??rias, dentre as quais podemos citar n??useas, ??mese, alop??cia, fadiga, anemia, diarr??ia, al??m de agravos bucais, principalmente a mucosite. A toxicidade sist??mica, pode gerar dist??rbios na hematopoiese, e por conseguinte, altera????es nos ??ndices hematol??gicos do paciente, culminando com imunossupress??o com ou sem mielosupress??o. Este estudo avaliou a incid??ncia dos agravos bucais prevalentes e ??ndices hematol??gicos em pacientes pedi??tricos com LLA-B que se encontravam em tratamento na Funda????o de Hematologia e Hemoterapia do Amazonas (HEMOAM), de acordo com o protocolo GBTLI LLA-2009. Os pacientes foram submetidos a exames intra-orais para a verifica????o da presen??a de agravos bucais, al??m da avala????o de seus ??ndices hematol??gicos ao longo da prefase e indu????o do tratamento quimioter??pico (QT). Os dados foram analisados pelos testes de Mann Whitney e teste exato de Fisher, com n??vel de signific??ncia de p ??? 0,05. Do total de 21 pacientes avaliados, 57,14% (n=12) foram do sexo masculino, com a m??dia de idade dos participantes sendo de 5 anos, e a maior parte pertencente ao grupo de baixo risco de recidiva (80,96%; n= 17). Em rela????o aos agravos bucais classicamente relacionados e/ou vistos durante o tratamento QT para LLA, foram encontrados 28,57% (n=6) dos pacientes apresentando altera????es bucais dessa natureza, sendo representadas sobretudo por mucosite. Por outro lado, 61,90% (n=13) dos pacientes apresentaram agravos bucais inespec??ficos, sendo a c??rie o mais prevalente, correspondendo a 71,42% (n=15). A maiorida dos pacientes apresentou leucocitose ao diagn??stico que foi substituida por leucopenia ao longo da prefase/indu????o, com queda semelhante nos ??ndices de linf??citos, neutr??filose e blastos, n??o havendo diferen??as significativas dos outros ??ndices. N??o foi encontrada correla????o entre agravos bucais e ??ndices hematol??gicos em nenhum dos momentos da prefase/indu????o do tratamento QT pelo protocolo GBTLI LLA 2009. Dessa maneira, concluiu-se que a incid??ncia de agravos bucais em pacientes com LLA-B tratados na Funda????o HEMOAM ?? relativamente baixa, aparentemente sem correla????o com os ??ndices hematol??gicos neste grupo de pacientes. Por outro lado, a baixa casu??stica de agravos bucais possivelmente est?? relacionada com presen??a do cirurgi??o-dentista na equipe multidisciplinar que presta atendimento ao paciente oncol??gico, prevenindo e tratando as manifesta????es orais que possam ocorrer durante a execu????o do tratamento.

Submitted by Monica Regina Hosannah da Silva e Silva (monicahosannah@gmail.com) on 2022-01-14T19:36:31Z No. of bitstreams: 3 FATORES DE RISCO ASSOCIADOS A DOEN??A ARTERIAL OBSTRUTIVA DE MEMBROS INFERIORES EM PACIENTES ATENDIDOS NO CENTRO DE ATEN????O A MELHOR IDADE DR. PAULO LIMA NA CIDADE DE MANAUS.pdf: 485094 bytes, checksum: 103efb1b97dd99303e54a993ba29eabe (MD5) Carta de encaminhamento do orientador.pdf: 196158 bytes, checksum: e9b87ef428a637bfb860f9211b9d4b56 (MD5) Ata de obten????o Mestrado Monica Hosannah.pdf: 537062 bytes, checksum: 201ec0f2011573d035a4783c9adc71e7 (MD5) Approved for entry into archive by PPGCS Ci??ncias da Sa??de (ppgmcsaude@ufam.edu.br) on 2022-01-31T22:21:31Z (GMT) No. of bitstreams: 3 FATORES DE RISCO ASSOCIADOS A DOEN??A ARTERIAL OBSTRUTIVA DE MEMBROS INFERIORES EM PACIENTES ATENDIDOS NO CENTRO DE ATEN????O A MELHOR IDADE DR. PAULO LIMA NA CIDADE DE MANAUS.pdf: 485094 bytes, checksum: 103efb1b97dd99303e54a993ba29eabe (MD5) Carta de encaminhamento do orientador.pdf: 196158 bytes, checksum: e9b87ef428a637bfb860f9211b9d4b56 (MD5) Ata de obten????o Mestrado Monica Hosannah.pdf: 537062 bytes, checksum: 201ec0f2011573d035a4783c9adc71e7 (MD5) Rejected by Divis??o de Documenta????o/BC Biblioteca Central (ddbc@ufam.edu.br), reason: Na ficha catalogr??fica, proceder com os ajustes: 1) H?? um subt??tulo inexistente na capa da disserta????o. O campo "Subt??tulo" deve ser deixado em branco; 2) No campo direcionado para escolher o curso, escolher "Mestrado em Patologia Tropical" ao inv??s de "Medicina"; 3) As palavras-chave 4 e 5 devem, tamb??m, iniciar com letra mai??scula. 4) No campo destinado ?? quantidade de folhas, inserir o n??mero da ??ltima folha numerada. on 2022-02-01T18:34:59Z (GMT) Submitted by Monica Regina Hosannah da Silva e Silva (monicahosannah@gmail.com) on 2022-02-03T21:13:40Z No. of bitstreams: 3 Carta de encaminhamento do orientador.pdf: 196158 bytes, checksum: e9b87ef428a637bfb860f9211b9d4b56 (MD5) Ata de obten????o Mestrado Monica Hosannah.pdf: 537062 bytes, checksum: 201ec0f2011573d035a4783c9adc71e7 (MD5) Disserta????o Mestrado Monica Regina Hosannah da Silva e Silva.pdf: 484514 bytes, checksum: de7deaba8cf46e74ecdc6c80fac8f806 (MD5) Approved for entry into archive by PPGCS Ci??ncias da Sa??de (ppgmcsaude@ufam.edu.br) on 2022-02-17T15:31:19Z (GMT) No. of bitstreams: 3 Carta de encaminhamento do orientador.pdf: 196158 bytes, checksum: e9b87ef428a637bfb860f9211b9d4b56 (MD5) Ata de obten????o Mestrado Monica Hosannah.pdf: 537062 bytes, checksum: 201ec0f2011573d035a4783c9adc71e7 (MD5) Disserta????o Mestrado Monica Regina Hosannah da Silva e Silva.pdf: 484514 bytes, checksum: de7deaba8cf46e74ecdc6c80fac8f806 (MD5) Approved for entry into archive by Divis??o de Documenta????o/BC Biblioteca Central (ddbc@ufam.edu.br) on 2022-02-18T13:19:40Z (GMT) No. of bitstreams: 3 Carta de encaminhamento do orientador.pdf: 196158 bytes, checksum: e9b87ef428a637bfb860f9211b9d4b56 (MD5) Ata de obten????o Mestrado Monica Hosannah.pdf: 537062 bytes, checksum: 201ec0f2011573d035a4783c9adc71e7 (MD5) Disserta????o Mestrado Monica Regina Hosannah da Silva e Silva.pdf: 484514 bytes, checksum: de7deaba8cf46e74ecdc6c80fac8f806 (MD5) Made available in DSpace on 2022-02-18T13:19:40Z (GMT). No. of bitstreams: 3 Carta de encaminhamento do orientador.pdf: 196158 bytes, checksum: e9b87ef428a637bfb860f9211b9d4b56 (MD5) Ata de obten????o Mestrado Monica Hosannah.pdf: 537062 bytes, checksum: 201ec0f2011573d035a4783c9adc71e7 (MD5) Disserta????o Mestrado Monica Regina Hosannah da Silva e Silva.pdf: 484514 bytes, checksum: de7deaba8cf46e74ecdc6c80fac8f806 (MD5) Previous issue date: 2005-09-30 Peripheral Obstructive Arterial Disease is a consequence of the atherosclerotic process leading to narrowing and stiffening of the arterial lumen. The presence of subclinical markers of atherosclerosis such as the ankle-brachial index below 0.90 demonstrated its predictive capacity for the diagnosis of atherosclerosis. This study aimed to identify the presence of peripheral arterial disease through the ankle-brachial index and its association with cardiovascular risk factors in the elderly. The study design was case-control, where cases were those with an ankle-brachial index equal to or below 0.90 and controls were individuals with an index above 0.90. Sixty-two (62) cases and 125 controls were included. The risk factors evaluated were: arterial hypertension, diabetes, obesity, smoking, physical activity, presence of angina, family history of cardiovascular disease, serum levels of total cholesterol and fractions, triglycerides, alcohol consumption. Statistical analysis was performed using univariate analysis. The statistical analysis was performed using univariate analysis. The following risk factors were associated with peripheral arterial disease: angina (OR 2,7 IC 95% 1,3-5,4), exertional angina (OR 2,4 IC 95% 1,2-4,9), psychological stress angina (OR 15,8 IC 1,9-131,4), angina at rest (OR 9,7 IC 95% 3,0-30,6), electrocardiogram abnormalities (OR 2,6 IC 95% 1,5-5,4), t-wave inversions (OR 2,8 IC95% 1,5 ??? 5,4), left ventricular hypertrophy (OR 2,7 IC 95% 1,3-5,2), serum glucose > 126 mg/dl (OR 4,1 IC 95% 1,3 12,7). Angina, electrocardiogram abnormalities suggesting coronary heart disease and diabetes were associated with peripheral arterial disease in elderly patients from CAIMI, Manaus. Key Word: Ankle-braquial index, Peripheral Obstructive Arterial Disease, cardiovascular risk factors, elderly A Doen??a Arterial Obstrutiva Perif??rica ?? consequ??ncia do processo ateroscler??tico levando ao estreitamento e enrijecimento da luz arterial. A presen??a de marcadores subcl??nicos de aterosclerose como o ??ndice tornozelo-braquial abaixo de 0,90 demonstrou sua capacidade preditiva para o diagn??stico de aterosclerose. O estudo visou identificar a presen??a da doen??a arterial obstrutiva perif??rica atrav??s do ??ndice tornozelo-braquial e sua associa????o com os fatores de risco cardiovascular em idosos. O delineamento de estudo foi do tipo caso-controle, onde os casos eram aqueles com ??ndice tornozelo-braquial igual ou abaixo de 0,90 e os controles eram indiv??duos com ??ndice acima de 0,90. Foram inclu??dos 62 casos e 125 controles. Os fatores de risco avaliados foram: hipertens??o arterial, diabetes, obesidade, tabagismo, atividade f??sica, presen??a de angina, hist??ria familiar de doen??a cardiovascular, n??veis s??ricos de colesterol total e fra????es, triglicer??deos, consumo de ??lcool. A an??lise estat??stica foi realizada por meio da an??lise univariada. Os seguintes fatores apresentaram associa????o com a doen??a obstrutiva perif??rica: angina (OR 2,7 IC 95% 1,3-5,4), angina por esfor??o f??sico (OR 2,4 IC 95% 1,2-4,9), angina por estresse (OR 15,8 IC 1,9-131,4), angina em repouso (OR 9,7 IC 95% 3,0-30,6), eletrocardiograma alterado (OR 2,6 IC 95% 1,5-5,4), invers??o de onda T (OR 2,8 IC95% 1,5 ??? 5,4), sobrecarga ventricular esquerda (OR 2,7 IC 95% 1,3-5,2), glicemia > 126 mg/dl (OR 4,1 IC 95% 1,3 12,7). O sintoma angina, altera????es eletrocardiogr??ficas sugestivas de doen??a coronariana cr??nica e diabetes encontram-se associados a doen??a arterial obstrutiva perif??rica em idosos atendidos no CAIMI em Manaus. Palavras chaves: ??ndice tornozelo-braquial, doen??a arterial obstrutiva perif??rica, fatores de risco cardiovascular, idosos.