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564 results on '"Fraedrich, Gustav"'

1. Associations of Perioperative Variables With the 30-Day Risk of Stroke or Death in Carotid Endarterectomy for Symptomatic Carotid Stenosis.

Author

Knappich, Christoph, Kuehnl, Andreas, Haller, Bernhard, Salvermoser, Michael, Algra, Ale, Becquemin, Jean-Pierre, Bonati, Leo H, Bulbulia, Richard, Calvet, David, Fraedrich, Gustav, Gregson, John, Halliday, Alison, Hendrikse, Jeroen, Howard, George, Jansen, Olav, Malas, Mahmoud B, Ringleb, Peter A, Brown, Martin M, Mas, Jean-Louis, Brott, Thomas G, Morris, Dylan R, Lewis, Steff C, and Eckstein, Hans-Henning

Subjects
Humans, Carotid Stenosis, Postoperative Complications, Anesthesia, Local, Anesthesia, General, Endarterectomy, Carotid, Risk Factors, Aged, Middle Aged, Female, Male, Stroke, anesthesia, death, endarterectomy, carotid, humans, stroke, Clinical Research, Neurosciences, Brain Disorders, endarterectomy, carotid, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Neurology & Neurosurgery
Abstract

Background and Purpose- This analysis was performed to assess the association between perioperative and clinical variables and the 30-day risk of stroke or death after carotid endarterectomy for symptomatic carotid stenosis. Methods- Individual patient-level data from the 5 largest randomized controlled carotid trials were pooled in the Carotid Stenosis Trialists' Collaboration database. A total of 4181 patients who received carotid endarterectomy for symptomatic stenosis per protocol were included. Determinants of outcome included carotid endarterectomy technique, type of anesthesia, intraoperative neurophysiological monitoring, shunting, antiplatelet medication, and clinical variables. Stroke or death within 30 days after carotid endarterectomy was the primary outcome. Adjusted risk ratios (aRRs) were estimated in multilevel multivariable analyses using a Poisson regression model. Results- Mean age was 69.5±9.2 years (70.7% men). The 30-day stroke or death rate was 4.3%. In the multivariable regression analysis, local anesthesia was associated with a lower primary outcome rate (versus general anesthesia; aRR, 0.70 [95% CI, 0.50-0.99]). Shunting (aRR, 1.43 [95% CI, 1.05-1.95]), a contralateral high-grade carotid stenosis or occlusion (aRR, 1.58 [95% CI, 1.02-2.47]), and a more severe neurological deficit (mRS, 3-5 versus 0-2: aRR, 2.51 [95% CI, 1.30-4.83]) were associated with higher primary outcome rates. None of the other characteristics were significantly associated with the perioperative stroke or death risk. Conclusions- The current results indicate lower perioperative stroke or death rates in patients operated upon under local anesthesia, whereas a more severe neurological deficit and a contralateral high-grade carotid stenosis or occlusion were identified as potential risk factors. Despite a possible selection bias and patients not having been randomized, these findings might be useful to guide surgeons and anesthetists when treating patients with symptomatic carotid disease.

Published
2019

2. Why do guidelines recommend screening for abdominal aortic aneurysms, but not for asymptomatic carotid stenosis? A plea for a randomized controlled trial

Author

Paraskevas, Kosmas I., Spence, J. David, Mikhailidis, Dimitri P., Antignani, Pier Luigi, Gloviczki, Peter, Eckstein, Hans-Henning, Spinelli, Francesco, Stilo, Francesco, Saba, Luca, Poredos, Pavel, Dardik, Alan, Liapis, Christos D., Mansilha, Armando, Faggioli, Gianluca, Pini, Rodolfo, Jezovnik, Mateja K., Sultan, Sherif, Musiałek, Piotr, Goudot, Guillaume, Lavenson, George S., Jr, Jawien, Arkadiusz, Blinc, Aleš, Myrcha, Piotr, Fernandes e Fernandes, Jose, Geroulakos, George, Kakkos, Stavros K., Knoflach, Michael, Proczka, Robert M., Capoccia, Laura, Rundek, Tatjana, Svetlikov, Alexei S., Silvestrini, Mauro, Ricco, Jean-Baptiste, Davies, Alun H., Di Lazzaro, Vincenzo, Suri, Jasjit S., Lanza, Gaetano, Fraedrich, Gustav, Zeebregts, Clark J., and Nicolaides, Andrew N.

Published
2023
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3. Carotid endarterectomy or stenting or best medical treatment alone for moderate-to-severe asymptomatic carotid artery stenosis: 5-year results of a multicentre, randomised controlled trial

Author

Beyersdorf, Friedhelm, Macharzina, Roland-Richard, Lechner, Gabriele, Menz, Carolin, Schonhardt, Sabine, Weinbeck, Michael, Greb, Olga, Otto, Dagmar, Winker, Thomas, Berger, Hermann, Poppert, Holger, Kühnl, Andreas, Pütz, Volker, Haase, Kathrin, Bodechtel, Ulf, Weiss, Norbert, Bergert, Hendrik, Meyne, Johannes, Groß, Justus, Kruse, Matthias, Gerdes, Berthold, Reinbold, Wolf-Dieter, Wuttig, Helge, Maier-Hasselmann, Andreas, Segerer, Manuela, Fuchs, Hans-Hermann, Gass, Sabine, Groden, Christoph, Niedergethmann, Marco, Griebe, Martin, Rosenkranz, Michael, Beck, Jürgen, Thomalla, Götz, Zeumer, Hermann H., Jauß, Marek, Kneist, Werner, Kneist, Martina, Staudacher, Thomas, Bernhard, Alfons, Jost, Petra, Prey, Nico, Knippschild, Jürgen, Kastrup, Oliver, Köhrmann, Martin, Frank, Benedikt, Bongers, Volkmar, Hoffmann, Johannes, Kniemeyer, Horst-Wilhelm, Knauth, Michael, Wasser, Kathrin, Stojanovic, Tomislav, Emmert, Hans, Tacke, Josef, Schwalbe, Bernhard, Nam, Eun-Mi, van Lengerich, Ulrike, Lowens, Stephan, Gröschel, Klaus, Uphaus, Timo, Gröschel, Sonja, Boor, Stephan, Dorweiler, Bernhard, Schmid, Elisabeth, Henkes, Hans, Hupp, Thomas, Singer, Oliver, Hamann, Gerhard, Wagner-Heck, Michaela, Kerth-Krick, Sibylle, Kilic, Metin, Huppert, Peter, Niederkorn, Kurt, Fruhwirth, Johannes, Klein, Günther, Pulkowski, Ulrich, Jöster, Karsten, Wacks, Jens-Henning, Kloppmann, Egbert, Vatankhah, Bijan, Hopf-Jensen, Silke, Stolze, Henning, Müller-Hülsbeck, Stefan, Walluscheck, Knut Peer, Schmitt, Hans-Michael, Grüger, Albert, Seemann, Jörg, Tilahun, Belay, Dichgans, Martin, Wollenweber, Frank Arne, Dörr, Angelika, Zollver, Adelgunde, Gäbel, Gabor, Hedtmann, Günter, Kollmar, Rainer, Claus, Detlef, Petermann, Christian, Kirsch, Stefanie, Bosnjak, Branko, Heiß, Johannes, Mühling, Holger, Wunderlich, Silke, Sabisch, Peter Nikolaus, Gahn, Georg, Storck, Martin, Arnold, Sebastian, Fischer, Urs, Gralla, Jan, von Mering, Matthias, Dißmann, Rüdiger, Kirsch, Delia, Schmidauer, Christoph, Waldenberger, Peter, Furtner, Martin, Kazarians, Haiko, Breuer, Peter, Arning, Christian, Rieper, Jürgen, Schmidt, Georg, Arnold, Marcel, Schroth, Gerhard, Weise, Jens, Zanow, Jürgen, Mayer, Thomas, Töpper, Rudolf, Gross-Fengels, Walter, Daum, Harald, Dittrich, Ralf, Ritter, Martin, Kasprzak, Bernd, Torsello, Giovanni, Pohlmann, Carsten, Brüning, Roland, Crispin, Alexander, Hofmann, Miriam, Müller, Thomas, Blessing, Erwin, Möhlenbruch, Markus, Ludwig, Ines, Amiri, Hemasse, Reiff, Tilman, Eckstein, Hans-Henning, Mansmann, Ulrich, Jansen, Olav, Fraedrich, Gustav, Mudra, Harald, Böckler, Dittmar, Böhm, Michael, Debus, E Sebastian, Fiehler, Jens, Mathias, Klaus, Ringelstein, Erich B, Schmidli, Jürg, Stingele, Robert, Zahn, Ralf, Zeller, Thomas, Niesen, Wolf-Dirk, Barlinn, Kristian, Binder, Andreas, Glahn, Jörg, Hacke, Werner, and Ringleb, Peter Arthur

Published
2022
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4. Optimal Management of Asymptomatic Carotid Stenosis in 2021: The Jury is Still Out. An International, Multispecialty, Expert Review and Position Statement

Author

Paraskevas, Kosmas I., Mikhailidis, Dimitri P., Antignani, Pier Luigi, Baradaran, Hediyeh, Bokkers, Reinoud P.H., Cambria, Richard P., Dardik, Alan, Davies, Alun H., Eckstein, Hans-Henning, Faggioli, Gianluca, e Fernandes, Jose Fernandes, Fraedrich, Gustav, Geroulakos, George, Gloviczki, Peter, Golledge, Jonathan, Gupta, Ajay, Jezovnik, Mateja K., Kakkos, Stavros K., Katsiki, Niki, Knoflach, Michael, Kooi, M. Eline, Lanza, Gaetano, Liapis, Christos D., Loftus, Ian M., Mansilha, Armando, Millon, Antoine, Nicolaides, Andrew N., Pini, Rodolfo, Poredos, Pavel, Ricco, Jean-Baptiste, Riles, Thomas S., Ringleb, Peter Arthur, Rundek, Tatjana, Saba, Luca, Schlachetzki, Felix, Silvestrini, Mauro, Spinelli, Francesco, Stilo, Francesco, Sultan, Sherif, Suri, Jasjit S., Zeebregts, Clark J., and Chaturvedi, Seemant

Published
2022
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8. Second asymptomatic carotid surgery trial (ACST-2): a randomised comparison of carotid artery stenting versus carotid endarterectomy

Author

Halliday, Alison, Bulbulia, Richard, Bonati, Leo H, Peto, Richard, Pan, Hongchao, Potter, John, Henning Eckstein, Hans, Farrell, Barbara, Flather, Marcus, Mansfield, Averil, Mihaylova, Boby, Rahimi, Kazim, Simpson, David, Thomas, Dafydd, Sandercock, Peter, Gray, Richard, Molyneux, Andrew, Shearman, Cliff P, Rothwell, Peter, Belli, Anna, Herrington, Will, Judge, Parminder, Leopold, Peter, Mafham, Marion, Gough, Michael, Cao, Piergiorgio, MacDonald, Sumaira, Bari, Vasha, Berry, Clive, Bradshaw, S, Brudlo, Wojciech, Clarke, Alison, Chester, Johanna, Cox, Robin, Cradduck-Bamford, Andrea, Fathers, Susan, Gaba, Kamran, Gray, Mo, Hayter, Elizabeth, Holliday, Constance, Kurien, Rijo, Lay, Michael, le Conte, Steffi, McManus, Jessica, Madgwick, Zahra, Morris, Dylan, Munday, Andrew, Pickworth, Sandra, Ostasz, Wiktor, Poorthuis, Michiel, Richards, Sue, Teixeira, Louisa, Tochlin, Sergey, Tully, Lynda, Wallis, Carol, Willet, Monique, Young, Alan, Casana, Renato, Malloggi, Chiara, Odero Jr, Andrea, Silani, Vincenzo, Parati, Gianfranco, Malchiodi, Giuseppe, Malferrari, Giovanni, Strozzi, Francesco, Tusini, Nicola, Vecchiati, Enrico, Coppi, Gioacchino, Lauricella, Antonio, Moratto, Roberto, Silingardi, Roberto, Veronesi, Jessica, Zini, Andrea, Ferrero, Emanuele, Ferri, Michelangelo, Gaggiano, Andrea, Labate, Carmelo, Nessi, Franco, Psacharopulo, Daniele, Viazzo, Andrea, Malacrida, Giovanni, Mazzaccaro, Daniela, Meola, Giovanni, Modafferi, Alfredo, Nano, Giovanni, Occhiuto, Maria Teresa, Righini, Paolo, Stegher, Silvia, Chiarandini, Stefano, Griselli, Filippo, Lepidi, Sandro, Pozzi Mucelli, Fabio, Naccarato, Marcello, D'Oria, Mario, Ziani, Barbara, Stella, Andrea, Dieng, Mortalla, Faggioli, Gianluca, Gargiulo, Mauro, Palermo, Sergio, Pini, Rodolfo, Puddu, Giovanni Maria, Vacirca, Andrea, Angiletta, Domenico, Desantis, Claudio, Marinazzo, Davide, Mastrangelo, Giovanni, Regina, Guido, Pulli, Raffaele, Bianchi, Paolo, Cireni, Lea, Coppi, Elisabetta, Pizzirusso, Rocco, Scalise, Filippo, Sorropago, Giovanni, Tolva, Valerio, Caso, Valeria, Cieri, Enrico, DeRango, Paola, Farchioni, Luca, Isernia, Giacomo, Lenti, Massimo, Parlani, Gian Battista, Pupo, Guglielmo, Pula, Grazia, Simonte, Gioele, Verzini, Fabio, Carimati, Federico, Delodovici, Maria Luisa, Fontana, Federico, Piffaretti, Gabriele, Tozzi, Matteo, Civilini, Efrem, Poletto, Giorgio, Reimers, Bernhard, Praquin, Barbara, Ronchey, Sonia, Capoccia, Laura, Mansour, Wassim, Sbarigia, Enrico, Speziale, Francesco, Sirignano, Pasqualino, Toni, Danilo, Galeotti, Roberto, Gasbarro, Vincenzo, Mascoli, Francesco, Rocca, Tiberio, Tsolaki, Elpiniki, Bernardini, Giulia, DeMarco, Ester, Giaquinta, Alessia, Patti, Francesco, Veroux, Massimiliano, Veroux, Pierfrancesco, Virgilio, Carla, Mangialardi, Nicola, Orrico, Matteo, Di Lazzaro, Vincenzo, Montelione, Nunzio, Spinelli, Francesco, Stilo, Francesco, Cernetti, Carlo, Irsara, Sandro, Maccarrone, Giuseppe, Tonello, Diego, Visonà, Adriana, Zalunardo, Beniamino, Chisci, Emiliano, Michelagnoli, Stefano, Troisi, Nicola, Masato, Maela, Dei Negri, Massimo, Pacchioni, Andrea, Saccà, Salvatore, Amatucci, Giovanni, Cannizzaro, Alfredo, Accrocca, Federico, Ambrogi, Cesare, Barbazza, Renzo, Marcucci, Giustino, Siani, Andrea, Bajardi, Guido, Savettieri, Giovanni, Argentieri, Angelo, Corbetta, Riccardo, Odero, Attilio, Quaretti, Pietro, Thyrion, Federico Z, Cappelli, Alessandro, Benevento, Domenico, De Donato, Gianmarco, Mele, Maria Agnese, Palasciano, Giancarlo, Pieragalli, Daniela, Rossi, Alessandro, Setacci, Carlo, Setacci, Francesco, Palombo, Domenico, Perfumo, Maria Cecilia, Martelli, Edoardo, Paolucci, Aldo, Trimarchi, Santi, Grassi, Viviana, Grimaldi, Luigi, La Rosa, Giuliana, Mirabella, Domenico, Scialabba, Matteo, Sichel, Leonildo, D'Angelo, Costantino L, Fadda, Gian Franco, Kasemi, Holta, Marino, Mario, Burzotta, Francesco, Codispoti, Francesco Alberto, Ferrante, Angela, Tinelli, Giovanni, Tshomba, Yamume, Vincenzoni, Claudio, Amis, Deborah, Anderson, Dawn, Catterson, Martin, Clarke, Mike, Davis, Michelle, Dixit, Anand, Dyker, Alexander, Ford, Gary, Jackson, Ralph, Kappadath, Sreevalsan, Lambert, David, Lees, Tim, Louw, Stephen, McCaslin, James, Parr, Noala, Robson, Rebecca, Stansby, Gerard, Wales, Lucy, Wealleans, Vera, Wilson, Lesley, Wyatt, Michael, Baht, Hardeep, Balogun, Ibrahim, Burger, Ilse, Cosier, Tracy, Cowie, Linda, Gunathilagan, Gunaratnam, Hargroves, David, Insall, Robert, Jones, Sally, Rudenko, Hannah, Schumacher, Natasha, Senaratne, Jawaharlal, Thomas, George, Thomson, Audrey, Webb, Tom, Brown, Ellen, Esisi, Bernard, Mehrzad, Ali, MacSweeney, Shane, McConachie, Norman, Southam, Alison, Sunman, Wayne, Abdul-Hamiq, Ahmed, Bryce, Jenny, Chetter, Ian, Ettles, Duncan, Lakshminarayan, Raghuram, Mitchelson, Kim, Rhymes, Christopher, Robinson, Graham, Scott, Paul, Vickers, Alison, Ashleigh, Ray, Butterfield, Stephen, Gamble, Ed, Ghosh, Jonathan, McCollum, Charles N, Welch, Mark, Welsh, Sarah, Wolowczyk, Leszek, Donnelly, Mary, D'Souza, Stephen, Egun, Anselm A, Gregary, Bindu, Joseph, Thomas, Kelly, Christine, Punekar, Shuja, Rahi, M Asad, Raj, Sonia, Seriki, Dare, Thomson, George, Brown, James, Durairajan, Ragunath, Grunwald, Iris, Guyler, Paul, Harman, Paula, Jakeways, Matthew, Khuoge, Christopher, Kundu, Ashish, Loganathan, Thayalini, Menon, Nisha, Prabakaran, Raji O, Sinha, Devesh, Thompson, Vicky, Tysoe, Sharon, Briley, Dennis, Darby, Chris, Hands, Linda, Howard, Dominic, Kuker, Wilhelm, Schulz, Ursula, Teal, Rachel, Barer, David, Brown, Andrew, Crawford, Susan, Dunlop, Paul, Krishnamurthy, Ramesh, Majmudar, Nikhil, Mitchell, Duncan, Myint, Min P, O'Brien, Richard, O'Connell, Janice, Sattar, Naweed, Vetrivel, Shanmugam, Beard, Jonathan, Cleveland, Trevor, Gaines, Peter, Humphreys, John, Jenkins, Alison, King, Craig, Kusuma, Daniel, Lindert, Ralph, Lonsdale, Robbie, Nair, Raj, Nawaz, Shah, Okhuoya, Faith, Turner, Douglas, Venables, Graham, Dorman, Paul, Hughes, Andrea, Jones, Deborah, Mendelow, David, Rodgers, Helen, Raudoniitis, Aidas, Enevoldson, Peter, Nahser, Hans, O'Brien, Imelda, Torella, Francesco, Watling, Dave, White, Richard, Brown, Pauline, Dutta, Dipankar, Emerson, Lorraine, Hilltout, Paula, Kulkarni, Sachin, Morrison, Jackie, Poskitt, Keith, Slim, Fiona, Smith, Sarah, Tyler, Amanda, Waldron, Joanne, Whyman, Mark, Bajoriene, Milda, Baker, Lucy, Colston, Amanda, Eliot-Jones, Bekky, Gramizadeh, Gita, Lewis-Clarke, Catherine, McCafferty, Laura, Oliver, Deborah, Palmer, Debbie, Patil, Abhijeet, Pegler, Suzannah, Ramadurai, Gopi, Roberts, Aisling, Sargent, Tracey, Siddegowda, Shivaprasad, Singh-Ranger, Ravi, Williams, Akintunde, Williams, Lucy, Windebank, Steve, Zuromskis, Tadas, Alwis, Lanka, Angus, Jane, Asokanathan, Asaipillai, Fornolles, Caroline, Hardy, Diana, Hunte, Sophy, Justin, Frances, Phiri, Duke, Mitabouana-Kibou, Marie, Sekaran, Lakshmanan, Sethuraman, Sakthivel, Tate, Margaret L, Akyea-Mensah, Joyce, Ball, Stephen, Chrisopoulou, Angela, Keene, Elizabeth, Phair, Alison, Rogers, Steven, Smyth, John V, Bicknell, Colin, Chataway, Jeremy, Cheshire, Nicholas, Clifton, Andrew, Eley, Caroline, Gibbs, Richard, Hamady, Mohammad, Hazel, Beth, James, Alex, Jenkins, Michael, Khanom, Nyma, Lacey, Austin, Mireskandari, Maz, O'Reilly, Joanna, Pereira, Antony, Sachs, Tina, Wolfe, John, Davey, Philip, Rogers, Gill, Smith, Gemma, Tervit, Gareth, Nichol, Ian, Parry, Andrew, Young, Gavin, Ashley, Simon, Barwell, James, Dix, Francis, Nor, Azlisham M, Parry, Chris, Birt, Angela, Davies, Paul, George, Jim, Graham, Anne, Jonker, Leon, Kelsall, Nicci, Potts, Caroline, Wilson, Toni, Crinnion, Jamie, Cuenoud, Larissa, Aleksic, Nikola, Babic, Srdan, Ilijevski, Nenad, Radak, Đorde, Sagic, Dragan, Tanaskovic, Slobodan, Colic, Momcilo, Cvetic, Vladimir, Davidovic, Lazar, Jovanovic, Dejana R, Koncar, Igor, Mutavdžic, Perica, Sladojevic, Miloš, Tomic, Ivan, Debus, Eike S, Grzyska, Ulrich, Otto, Dagmar, Thomalla, Götz, Barlinn, Jessica, Gerber, Johannes, Haase, Kathrin, Hartmann, Christian, Ludwig, Stefan, Pütz, Volker, Reeps, Christian, Schmidt, Christine, Weiss, Norbert, Werth, Sebastian, Winzer, Simon, Gemper, Janine, Günther, Albrecht, Heiling, Bianka, Jochmann, Elisabeth, Karvouniari, Panagiota, Klingner, Carsten, Mayer, Thomas, Schubert, Julia, Schulze-Hartung, Friederike, Zanow, Jürgen, Bausback, Yvonne, Borger, Franka, Botsios, Spiridon, Branzan, Daniela, Bräunlich, Sven, Hölzer, Henryk, Lenzer, Janin, Piorkowski, Christopher, Richter, Nadine, Schuster, Johannes, Scheinert, Dierk, Schmidt, Andrej, Staab, Holger, Ulrich, Matthias, Werner, Martin, Berger, Hermann, Biró, Gábor, Eckstein, Hans-Henning, Kallmayer, Michael, Kreiser, Kornelia, Zimmermann, Alexander, Berekoven, Bärbel, Frerker, Klaus, Gordon, Vera, Torsello, Giovanni, Arnold, Sebastian, Dienel, Cora, Storck, Martin, Biermaier, Bernhard, Gissler, Hans Martin, Klötzsch, Christof, Pfeiffer, Tomas, Schneider, Ralph, Söhl, Leander, Wennrich, Michael, Alonso, Angelika, Keese, Michael, Groden, Christoph, Cöster, Andreas, Engelhardt, Andreas, Ratusinski, Christoph-Maria, Berg, Bengt, Delle, Martin, Formgren, Johan, Gillgren, Peter, Jarl, Lotta, Kall, Torbjörn B, Konrad, Peter, Nyman, Niklas, Skiöldebrand, Claes, Steuer, Johnny, Takolander, Rabbe, Malmstedt, Jonas, Acosta, Stefan, Björses, Katarina, Brandt, Kerstin, Dias, Nuno, Gottsäter, Anders, Holst, Jan, Kristmundsson, Thorarinn, Kühme, Tobias, Kölbel, Tilo, Lindblad, Bengt, Lindh, Mats, Malina, Martin, Ohrlander, Tomas, Resch, Tim, Rönnle, Viola, Sonesson, Björn, Warvsten, Margareta, Zdanowski, Zbigniew, Campbell, Erik, Kjellin, Per, Lindgren, Hans, Nyberg, Johan, Petersen, Björn, Plate, Gunnar, Pärsson, Håkan, Qvarfordt, Peter, Ignatenko, Pavel, Karpenko, Andrey, Starodubtsev, Vladimir, Chernyavsky, Mikhail A, Golovkova, Maria S, Komakha, Boris B, Zherdev, Nikolay N, Belyasnik, Andrey, Chechulov, Pavel, Kandyba, Dmitry, Stepanishchev, Igor, Csobay-Novák, Csaba, Dósa, Edit, Entz, László, Nemes, Balázs, Szeberin, Zoltán, Barzó, Pál, Bodosi, Mihaly, Fákó, Eniko, Fülöp, Béla, Németh, Tamás, Pazdernyik, Szilárd, Skoba, Krisztina, Vörös, Erika, Chatzinikou, Eleni, Giannoukas, Athanasios, Karathanos, Christos, Koutsias, Stylianos, Kouvelos, Georgios, Matsagkas, Miltiadis, Ralli, Styliani, Rountas, Christos, Rousas, Nikolaos, Spanos, Konstantinos, Brountzos, Elias, Kakisis, John D, Lazaris, Andreas, Moulakakis, Konstantinos G, Stefanis, Leonidas, Tsivgoulis, Georgios, Vasdekis, Spyros, Antonopoulos, Constantine N, Bellenis, Ion, Maras, Dimitrios, Polydorou, Antonios, Polydorou, Victoria, Tavernarakis, Antonios, Ioannou, Nikolaos, Terzoudi, Maria, Lazarides, Miltos, Mantatzis, Michalis, Vadikolias, Kostas, Dzieciuchowicz, Lukasz, Gabriel, Marcin, Krasinski, Zbigniew, Oszkinis, Grzegorz, Pukacki, Fryderyk, Slowinski, Maciej, Stanišic, Michal-Goran, Staniszewski, Ryszard, Tomczak, Jolanta, Zielinski, Maciej, Myrcha, Piotr, Rózanski, Dorota, Drelichowski, Stanislaw, Iwanowski, Wojciech, Koncewicz, Katarzyna, Bialek, Pawel, Biejat, Zbigniew, Czepel, Wojciech, Czlonkowska, Anna, Dowzenko, Anatol, Jedrzejewska, Julia, Kobayashi, Adam, Leszczynski, Jerzy, Malek, Andrzej, Polanski, Jerzy, Proczka, Robert, Skorski, Maciej, Szostek, Mieczyslaw, Andziak, Piotr, Dratwicki, Maciej, Gil, Robert, Nowicki, Miroslaw, Pniewski, Jaroslaw, Rzezak, Jaroslaw, Seweryniak, Piotr, Dabek, Pawel, Juszynski, Michal, Madycki, Grzegorz, Pacewski, Bartosz, Raciborski, Witold, Slowinski, Piotr, Staszkiewicz, Walerian, Bombic, Martin, Chlouba, Vladimír, Fiedler, Jirí, Hes, Karel, Koštál, Petr, Sova, Jindrich, Kríž, Zdenek, Prívara, Mojmír, Reif, Michal, Staffa, Robert, Vlachovský, Robert, Vojtíšek, Bohuslav, Hrbác, Tomáš, Kuliha, Martin, Procházka, Václav, Roubec, Martin, Školoudík, David, Netuka, David, Šteklácová, Anna, Beneš III, Vladimír, Buchvald, Pavel, Endrych, Ladislav, Šercl, Miroslav, Campos Jr, Walter, Casella, Ivan B, de Luccia, Nelson, Estenssoro, André E V, Presti, Calógero, Puech-Leão, Pedro, Neves, Celso R B, da Silva, Erasmo S, Sitrângulo Jr, Cid J, Monteiro, José A T, Tinone, Gisela, Bellini Dalio, Marcelo, Joviliano, Edwaldo E, Pontes Neto, Octávio M, Serra Ribeiro, Mauricio, Cras, Patrick, Hendriks, Jeroen M H, Hoppenbrouwers, Mieke, Lauwers, Patrick, Loos, Caroline, Yperzeele, Laetitia, Geenens, Mia, Hemelsoet, Dimitri, van Herzeele, Isabelle, Vermassen, Frank, Astarci, Parla, Hammer, Frank, Lacroix, Valérie, Peeters, André, Verhelst, Robert, Cirelli, Silvana, Dormal, Pol, Grimonprez, Annelies, Lambrecht, Bart, Lerut, Philipe, Thues, Eddy, De Koster, Guy, Desiron, Quentin, Maertens de Noordhout, Alain, Malmendier, Danielle, Massoz, Mireille, Saad, Georges, Bosiers, Marc, Callaert, Joren, Deloose, Koen, Blanco Cañibano, Estrella, García Fresnillo, Beatriz, Guerra Requena, Mercedes, Morata Barrado, Pilar C, Muela Méndez, Miguel, Yusta Izquierdo, Antonio, Aparici Robles, Fernando, Blanes Orti, Paula, García Dominguez, Luis, Martínez López, Rafael, Miralles Hernández, Manuel, Tembl Ferrairo, José I, Chamorro, Ángel, Macho, Juan, Obach, Víctor, Riambau, Vincent, San Román, Luis, Ahlhelm, Frank J, Blackham, Kristine, Engelter, Stefan, Eugster, Thomas, Gensicke, Henrik, Gürke, Lorenz, Lyrer, Philippe, Mariani, Luigi, Maurer, Marina, Mujagic, Edin, Müller, Mandy, Psychogios, Marios, Stierli, Peter, Stippich, Christoph, Traenka, Christopher, Wolff, Thomas, Wagner, Benjamin, Wiegert, Martina M, Clarke, Sandra, Diepers, Michael, Gröchenig, Ernst, Gruber, Philipp, Isaak, Andrej, Kahles, Timo, Marti, Regula, Nedeltchev, Krassen, Remonda, Luca, Tissira, Nadir, Valença Falcão, Martina, de Borst, Gert J, Lo, Rob H, Moll, Frans L, Toorop, Raechel, van der Worp, Bart H, Vonken, Evert J, Kappelle, Jaap L, Jahrome, Ommid, Vos, Floris, Schuiling, Wouter, van Overhagen, Hendrik, Keunen, Rudolf W M, Knippenberg, Bob, Wever, Jan J, Lardenoije, Jan W, Reijnen, Michel, Smeets, Luuk, van Sterkenburg, Steven, Fraedrich, Gustav, Gizewski, Elke, Gruber, Ingrid, Knoflach, Michael, Kiechl, Stefan, Rantner, Barbara, Abdulamit, Timur, Bergeron, Patrice, Padovani, Raymond, Trastour, Jean-Christophe, Cardon, Jean-Marie, Le Gallou-Wittenberg, Anne, Allaire, Eric, Becquemin, Jean-Pierre, Cochennec-Paliwoda, Frédéric, Desgranges, Pascal, Hosseini, Hassan, Kobeiter, Hicham, Marzelle, Jean, Almekhlafi, Mohammed A, Bal, Simerpreet, Barber, Phillip A, Coutts, Shelagh B, Demchuk, Andrew M, Eesa, Muneer, Gillies, Michelle, Goyal, Mayank, Hill, Michael D, Hudon, Mark E, Jambula, Anitha, Kenney, Carol, Klein, Gary, McClelland, Marie, Mitha, Alim, Menon, Bijoy K, Morrish, William F, Peters, Steven, Ryckborst, Karla J, Samis, Greg, Save, Supriya, Smith, Eric E, Stys, Peter, Subramaniam, Suresh, Sutherland, Garnette R, Watson, Tim, Wong, John H, Zimmel, L, Flis, Vojko, Matela, Jože, Miksic, Kazimir, Milotic, Franko, Mrdja, Božidar, Stirn, Barbara, Tetickovic, Erih, Gasparini, Mladen, Grad, Anton, Kompara, Ingrid, Miloševic, Zoren, Palmiste, Veronika, Toomsoo, Toomas, Aidashova, Balzhan, Kospanov, Nursultan, Lyssenko, Roman, Mussagaliev, Daulet, Beyar, Rafi, Hoffman, Aaron, Karram, Tony, Kerner, Arthur, Nikolsky, Eugenia, Nitecki, Samy, Andonova, Silva, Bachvarov, Chavdar, Petrov, Vesko, Cvjetko, Ivan, Vidjak, Vinko, Halužan, Damir, Petrunic, Mladen, Liu, Bao, Liu, Chang-Wei, Bartko, Daniel, Beno, Peter, Rusnák, František, Zelenák, Kamil, Ezura, Masayuki, Inoue, Takashi, Kimura, Naoto, Kondo, Ryushi, Matsumoto, Yasushi, Shimizu, Hiroaki, Endo, Hidenori, Furui, Eisuke, Bakke, Søren, Krohg-Sørensen, Kristen, Nome, Terje, Skjelland, Mona, Tennøe, Bjørn, Albuquerque e Castro, João, Alves, Gonçalo, Bastos Gonçalves, Frederico, de Aragão Morais, José, Garcia, Ana C, Valentim, Hugo, Vasconcelos, Leonor, Belcastro, Fernando, Cura, Fernando, Zaefferer, Patricio, Abd-Allah, Foad, Eldessoki, Mohamed H, Heshmat Kassem, Hussein, Soliman Gharieb, Haytham, Colgan, Mary P, Haider, Syed N, Harbison, Joe, Madhavan, Prakash, Moore, Dermot, Shanik, Gregor, Kazan, Viviane, Nazzal, Munier, and Ramsey-Williams, Vicki

Published
2021
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9. Contralateral Stenosis and Echolucent Plaque Morphology are Associated with Elevated Stroke Risk in Patients Treated with Asymptomatic Carotid Artery Stenosis within a Controlled Clinical Trial (SPACE-2)

Author

Beyersdorf, F, Grügerny, M, Macharzina, R-R, Lechner, G, Menz, C, Schonhardt, S, Weinbeck, M, Greb, O, Otto, D, Winker, T, Berger, H, Poppert, H, Pütz, V, Haase, K, Bodechtel, U, Weiss, N, Bergert, H, Meyne, J, Groß, J, Botsch, A, Kruse, M, Gerdes, B, Reinbold, WD, Wuttig, H, Maier-Hasselmann, A, Segerer, M, Fuchs, H-H, Gass, S, Schultz, H, Groden, C, Niedergethman, M, Griebe, M, Rosenkranz, M, Beck, C, Thomalla, G, Zeumer, H, Jauß, M, Kneist, W, Kneist, M, Staudacher, T, Bernhard, A, Jost, D, Prey, N, Knippschild, J, Kastrup, O, Köhrmann, M, Frank, B, Bongers, V, Hoffmann, J, Kniemeyer, H-W, Knauth, M, Wasser, K, Stojanovic, T, Emmert, H, Tacke, J, Schwalbe, B, Nam, E-M, van Lengerich, U, Lowens, S, Gröschel, K, Uphaus, T, Gröschel, S, Boor, S, Dorweiler, B, Schmid, E, Henkes, H, Hupp, T, Singer, O, Hamann, G, Wagner-Heck, M, Kerth-Krick, S, Kilic, M, Huppert, P, Niederkorn, K, Fruhwirth, J, Klein, G, Pulkowski, U, Jöster, K, Wacks, J-H, Kloppmann, E, Vatankhah, B, Hopf-Jensen, S, Stolze, H, Müller-Hülsbeck, S, Walluscheck, KP, Schmitt, H-M, Grüger, A, Seemann, J, Tilahun, B, Dichgans, M, Wollenweber, F, Dörr, A, Zollver, A, Gäbel, G, Hedtmann, G, Kollmar, R, Claus, D, Petermann, C, Kirsch, S, Bosnjak, B, Heiß, J, Mühling, H, Wunderlich, S, Sabisch, PN, Gahn, G, Storck, M, Arnold, S, Fischer, U, Gralla, J, von Mering, M, Dißmann, R, Kirsch, D, Schmidauer, C, Waldenberger, P, Furtner, M, Kazarians, H, Breuer, P, Arning, C, Rieper, J, Schmidt, G, Arnold, M, Schroth, G, Weise, J, Zanow, J, Mayer, T, Töpper, R, Gross-Fengels, W, Daum, H, Dittrich, R, Ritter, M, Kasprzak, B, Torsello, G, Pohlmann, C, Brüning, R, Amiri, H, Ludwig, I, Blessing, E, Möhlenbruch, M, Crispin, A, Hofman, M, Müller, T, Reiff, Tilman, Eckstein, Hans-Henning, Mansmann, Ulrich, Jansen, Olav, Fraedrich, Gustav, Mudra, Harald, Böckler, Dittmar, Böhm, Michael, Brückmann, Hartmut, Debus, E. Sebastian, Fiehler, Jens, Mathias, Klaus, Ringelstein, E. Bernd, Schmidli, Jürg, Stingele, Robert, Zahn, Ralf, Zeller, Thomas, Niesen, Wolf-Dirk, Barlinn, Kristian, Binder, Andreas, Glahn, Jörg, and Ringleb, Peter Arthur

Published
2021
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14. Long-term outcomes of stenting and endarterectomy for symptomatic carotid stenosis: a preplanned pooled analysis of individual patient data

Author

Brott, Thomas G, Calvet, David, Howard, George, Gregson, John, Algra, Ale, Becquemin, Jean-Pierre, de Borst, Gert J, Bulbulia, Richard, Eckstein, Hans-Henning, Fraedrich, Gustav, Greving, Jacoba P, Halliday, Alison, Hendrikse, Jeroen, Jansen, Olav, Voeks, Jenifer H, Ringleb, Peter A, Mas, Jean-Louis, Brown, Martin M, and Bonati, Leo H

Published
2019
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21. Association between age and risk of stroke or death from carotid endarterectomy and carotid stenting: a meta-analysis of pooled patient data from four randomised trials

Author

Howard, George, Roubin, Gary S, Jansen, Olav, Hendrikse, Jeroen, Halliday, Alison, Fraedrich, Gustav, Eckstein, Hans-Henning, Calvet, David, Bulbulia, Richard, Bonati, Leo H, Becquemin, Jean-Pierre, Algra, Ale, Brown, Martin M, Ringleb, Peter A, Brott, Thomas G, and Mas, Jean-Louis

Published
2016
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23. Secular Trends in Procedural Stroke or Death Risks of Stenting Versus Endarterectomy for Symptomatic Carotid Stenosis: A Pooled Analysis of Randomized Trials

Author

Müller, Mandy D., von Felten, Stefanie, Algra, Ale, Becquemin, Jean-Pierre, Bulbulia, Richard, Calvet, David, Eckstein, Hans-Henning, Fraedrich, Gustav, Halliday, Alison, Hendrikse, Jeroen, Howard, George, Gregson, John, Jansen, Olav, Brown, Martin M., Mas, Jean-Louis, Brott, Thomas G., Ringleb, Peter A., and Bonati, Leo H.

Published
2019
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24. Safety of Carotid Revascularization in Patients With a History of Coronary Heart Disease

Author

Volkers, Eline J., Algra, Ale, Kappelle, L. Jaap, Becquemin, Jean-Pierre, de Borst, Gert J., Brown, Martin M., Bulbulia, Richard, Calvet, David, Eckstein, Hans-Henning, Fraedrich, Gustav, Gregson, John, Halliday, Alison, Hendrikse, Jeroen, Howard, George, Jansen, Olav, Roubin, Gary S., Bonati, Leo H., Brott, Thomas G., Mas, Jean-Louis, Ringleb, Peter A., and Greving, Jacoba P.

Published
2019
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25. Screening for asymptomatic carotid stenosis in patients with non-valvular atrial fibrillation

Author

Paraskevas, Kosmas I., primary, Eckstein, Hans-Henning, additional, Mansilha, Armando, additional, Ricco, Jean-Baptiste, additional, Geroulakos, George, additional, Di Lazzaro, Vincenzo, additional, Rundek, Tatjana, additional, Lanza, Gaetano, additional, Fraedrich, Gustav, additional, Svetlikov, Alexei S., additional, Suri, Jasjit S., additional, Zeebregts, Clark J., additional, Davies, Alun H., additional, Capoccia, Laura, additional, Proczka, Robert M., additional, Myrcha, Piotr, additional, Antignani, Pier Luigi, additional, Fernandes e Fernandes, Jose, additional, Spence, J. David, additional, Dardik, Alan, additional, Jezovnik, Mateja K., additional, Knoflach, Michael, additional, Lavenson, George S., additional, Kakkos, Stavros K., additional, Jawien, Arkadiusz, additional, Silvestrini, Mauro, additional, Blinc, Aleš, additional, Spinelli, Francesco, additional, Stilo, Francesco, additional, Musiałek, Piotr, additional, Sultan, Sherif, additional, Goudot, Guillaume, additional, Liapis, Christos D., additional, Saba, Luca, additional, Faggioli, Gianluca, additional, Pini, Rodolfo, additional, Poredos, Pavel, additional, Mikhailidis, Dimitri P., additional, Gloviczki, Peter, additional, and Nicolaides, Andrew N., additional

Published
2023
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26. Clarifying the rationale supporting selective screening for asymptomatic carotid artery stenosis

Author

Paraskevas, Kosmas I., primary, Nicolaides, Andrew N., additional, Spence, J. David, additional, Mikhailidis, Dimitri P., additional, Lanza, Gaetano, additional, Liapis, Christos D., additional, Goudot, Guillaume, additional, Faggioli, Gianluca, additional, Pini, Rodolfo, additional, Musiałek, Piotr, additional, Suri, Jasjit S., additional, Silvestrini, Mauro, additional, Fernandes e Fernandes, Jose, additional, Eckstein, Hans-Henning, additional, Jawien, Arkadiusz, additional, Spinelli, Francesco, additional, Stilo, Francesco, additional, Myrcha, Piotr, additional, Rundek, Tatjana, additional, Kakkos, Stavros K., additional, Di Lazzaro, Vincenzo, additional, Svetlikov, Alexei, additional, Antignani, Pier Luigi, additional, Poredos, Pavel, additional, Saba, Luca, additional, Jezovnik, Mateja K., additional, Blinc, Aleš, additional, Sultan, Sherif, additional, Knoflach, Michael, additional, Capoccia, Laura, additional, Proczka, Robert M., additional, Fraedrich, Gustav, additional, Zeebregts, Clark J., additional, Davies, Alun H., additional, Geroulakos, George, additional, Ricco, Jean-Baptiste, additional, Mansilha, Armando, additional, Dardik, Alan, additional, and Gloviczki, Peter, additional

Published
2023
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29. Carotid endarterectomy or stenting or best medical treatment alone for moderate-to-severe asymptomatic carotid artery stenosis: 5-year results of a multicentre, randomised controlled trial

Author

Reiff, Tilman, primary, Eckstein, Hans-Henning, additional, Mansmann, Ulrich, additional, Jansen, Olav, additional, Fraedrich, Gustav, additional, Mudra, Harald, additional, Böckler, Dittmar, additional, Böhm, Michael, additional, Debus, E Sebastian, additional, Fiehler, Jens, additional, Mathias, Klaus, additional, Ringelstein, Erich B, additional, Schmidli, Jürg, additional, Stingele, Robert, additional, Zahn, Ralf, additional, Zeller, Thomas, additional, Niesen, Wolf-Dirk, additional, Barlinn, Kristian, additional, Binder, Andreas, additional, Glahn, Jörg, additional, Hacke, Werner, additional, Ringleb, Peter Arthur, additional, Beyersdorf, Friedhelm, additional, Macharzina, Roland-Richard, additional, Lechner, Gabriele, additional, Menz, Carolin, additional, Schonhardt, Sabine, additional, Weinbeck, Michael, additional, Greb, Olga, additional, Otto, Dagmar, additional, Winker, Thomas, additional, Berger, Hermann, additional, Poppert, Holger, additional, Kühnl, Andreas, additional, Pütz, Volker, additional, Haase, Kathrin, additional, Bodechtel, Ulf, additional, Weiss, Norbert, additional, Bergert, Hendrik, additional, Meyne, Johannes, additional, Groß, Justus, additional, Kruse, Matthias, additional, Gerdes, Berthold, additional, Reinbold, Wolf-Dieter, additional, Wuttig, Helge, additional, Maier-Hasselmann, Andreas, additional, Segerer, Manuela, additional, Fuchs, Hans-Hermann, additional, Gass, Sabine, additional, Groden, Christoph, additional, Niedergethmann, Marco, additional, Griebe, Martin, additional, Rosenkranz, Michael, additional, Beck, Jürgen, additional, Thomalla, Götz, additional, Zeumer, Hermann H., additional, Jauß, Marek, additional, Kneist, Werner, additional, Kneist, Martina, additional, Staudacher, Thomas, additional, Bernhard, Alfons, additional, Jost, Petra, additional, Prey, Nico, additional, Knippschild, Jürgen, additional, Kastrup, Oliver, additional, Köhrmann, Martin, additional, Frank, Benedikt, additional, Bongers, Volkmar, additional, Hoffmann, Johannes, additional, Kniemeyer, Horst-Wilhelm, additional, Knauth, Michael, additional, Wasser, Kathrin, additional, Stojanovic, Tomislav, additional, Emmert, Hans, additional, Tacke, Josef, additional, Schwalbe, Bernhard, additional, Nam, Eun-Mi, additional, van Lengerich, Ulrike, additional, Lowens, Stephan, additional, Gröschel, Klaus, additional, Uphaus, Timo, additional, Gröschel, Sonja, additional, Boor, Stephan, additional, Dorweiler, Bernhard, additional, Schmid, Elisabeth, additional, Henkes, Hans, additional, Hupp, Thomas, additional, Singer, Oliver, additional, Hamann, Gerhard, additional, Wagner-Heck, Michaela, additional, Kerth-Krick, Sibylle, additional, Kilic, Metin, additional, Huppert, Peter, additional, Niederkorn, Kurt, additional, Fruhwirth, Johannes, additional, Klein, Günther, additional, Pulkowski, Ulrich, additional, Jöster, Karsten, additional, Wacks, Jens-Henning, additional, Kloppmann, Egbert, additional, Vatankhah, Bijan, additional, Hopf-Jensen, Silke, additional, Stolze, Henning, additional, Müller-Hülsbeck, Stefan, additional, Walluscheck, Knut Peer, additional, Schmitt, Hans-Michael, additional, Grüger, Albert, additional, Seemann, Jörg, additional, Tilahun, Belay, additional, Dichgans, Martin, additional, Wollenweber, Frank Arne, additional, Dörr, Angelika, additional, Zollver, Adelgunde, additional, Gäbel, Gabor, additional, Hedtmann, Günter, additional, Kollmar, Rainer, additional, Claus, Detlef, additional, Petermann, Christian, additional, Kirsch, Stefanie, additional, Bosnjak, Branko, additional, Heiß, Johannes, additional, Mühling, Holger, additional, Wunderlich, Silke, additional, Sabisch, Peter Nikolaus, additional, Gahn, Georg, additional, Storck, Martin, additional, Arnold, Sebastian, additional, Fischer, Urs, additional, Gralla, Jan, additional, von Mering, Matthias, additional, Dißmann, Rüdiger, additional, Kirsch, Delia, additional, Schmidauer, Christoph, additional, Waldenberger, Peter, additional, Furtner, Martin, additional, Kazarians, Haiko, additional, Breuer, Peter, additional, Arning, Christian, additional, Rieper, Jürgen, additional, Schmidt, Georg, additional, Arnold, Marcel, additional, Schroth, Gerhard, additional, Weise, Jens, additional, Zanow, Jürgen, additional, Mayer, Thomas, additional, Töpper, Rudolf, additional, Gross-Fengels, Walter, additional, Daum, Harald, additional, Dittrich, Ralf, additional, Ritter, Martin, additional, Kasprzak, Bernd, additional, Torsello, Giovanni, additional, Pohlmann, Carsten, additional, Brüning, Roland, additional, Crispin, Alexander, additional, Hofmann, Miriam, additional, Müller, Thomas, additional, Blessing, Erwin, additional, Möhlenbruch, Markus, additional, Ludwig, Ines, additional, and Amiri, Hemasse, additional

Published
2022
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30. Optimal periprocedural antithrombotic treatment in carotid interventions: An international, multispecialty, expert review and position statement

Author

Paraskevas, Kosmas I., primary, Gloviczki, Peter, additional, Mikhailidis, Dimitri P., additional, Antignani, Pier Luigi, additional, Dardik, Alan, additional, Eckstein, Hans-Henning, additional, Faggioli, Gianluca, additional, Fernandes e Fernandes, Jose, additional, Fraedrich, Gustav, additional, Gupta, Ajay, additional, Jawien, Arkadiusz, additional, Jezovnik, Mateja K., additional, Kakkos, Stavros K., additional, Knoflach, Michael, additional, Lal, Brajesh K., additional, Lanza, Gaetano, additional, Liapis, Christos D., additional, Loftus, Ian M., additional, Mansilha, Armando, additional, Millon, Antoine, additional, Pini, Rodolfo, additional, Poredos, Pavel, additional, Proczka, Robert M., additional, Ricco, Jean-Baptiste, additional, Rundek, Tatjana, additional, Saba, Luca, additional, Schlachetzki, Felix, additional, Silvestrini, Mauro, additional, Spinelli, Francesco, additional, Stilo, Francesco, additional, Suri, Jasjit S., additional, Zeebregts, Clark J., additional, Lavie, Carl J., additional, and Chaturvedi, Seemant, additional

Published
2022
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31. Prediction Models for Clinical Outcome After a Carotid Revascularization Procedure: An External Validation Study

Author

Volkers, Eline J., Algra, Ale, Kappelle, L. Jaap, Jansen, Olav, Howard, George, Hendrikse, Jeroen, Halliday, Alison, Gregson, John, Fraedrich, Gustav, Eckstein, Hans-Henning, Calvet, David, Bulbulia, Richard, Brown, Martin M., Becquemin, Jean-Pierre, Ringleb, Peter A., Mas, Jean-Louis, Bonati, Leo H., Brott, Thomas G., and Greving, Jacoba P.

Published
2018
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36. Traumatic Injury of Upper Extremity Arteries

Author

Klocker, Josef, Fraedrich, Gustav, Arnold, Wolfgang, editor, Ganzer, Uwe, editor, Liapis, Christos D., editor, Balzer, Klaus, editor, Benedetti-Valentini, Fabrizio, editor, and Fernandes e Fernandes, José, editor

Published
2007
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37. Benefits and drawbacks of statins and non-statin lipid lowering agents in carotid artery disease

Author

Paraskevas, Kosmas I., primary, Gloviczki, Peter, additional, Antignani, Pier Luigi, additional, Comerota, Anthony J., additional, Dardik, Alan, additional, Davies, Alun H., additional, Eckstein, Hans-Henning, additional, Faggioli, Gianluca, additional, Fernandes e Fernandes, Jose, additional, Fraedrich, Gustav, additional, Geroulakos, George, additional, Golledge, Jonathan, additional, Gupta, Ajay, additional, Gurevich, Victor S., additional, Jawien, Arkadiusz, additional, Jezovnik, Mateja K., additional, Kakkos, Stavros K., additional, Knoflach, Michael, additional, Lanza, Gaetano, additional, Liapis, Christos D., additional, Loftus, Ian M., additional, Mansilha, Armando, additional, Nicolaides, Andrew N., additional, Pini, Rodolfo, additional, Poredos, Pavel, additional, Proczka, Robert M., additional, Ricco, Jean-Baptiste, additional, Rundek, Tatjana, additional, Saba, Luca, additional, Schlachetzki, Felix, additional, Silvestrini, Mauro, additional, Spinelli, Francesco, additional, Stilo, Francesco, additional, Suri, Jasjit S., additional, Svetlikov, Alexei V., additional, Zeebregts, Clark J., additional, Chaturvedi, Seemant, additional, Veith, Frank J., additional, and Mikhailidis, Dimitri P., additional

Published
2022
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40. Early Endarterectomy Carries a Lower Procedural Risk Than Early Stenting in Patients With Symptomatic Stenosis of the Internal Carotid Artery: Results From 4 Randomized Controlled Trials

Author

Rantner, Barbara, Kollerits, Barbara, Roubin, Gary S., Ringleb, Peter A., Jansen, Olaf, Howard, George, Hendrikse, Jeroen, Halliday, Alison, Gregson, John, Eckstein, Hans-Henning, Calvet, David, Bulbulia, Richard, Bonati, Leo H., Becquemin, Jean-Pierre, Algra, Ale, Brown, Martin M., Mas, Jean-Louis, Brott, Thomas G., and Fraedrich, Gustav

Published
2017
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45. Comparison of Recent Practice Guidelines for the Management of Patients With Asymptomatic Carotid Stenosis

Author

Paraskevas, Kosmas I., primary, Mikhailidis, Dimitri P., additional, Antignani, Pier Luigi, additional, Ascher, Enrico, additional, Baradaran, Hediyeh, additional, Bokkers, Reinoud P.H., additional, Cambria, Richard P., additional, Comerota, Anthony J., additional, Dardik, Alan, additional, Davies, Alun H., additional, Eckstein, Hans-Henning, additional, Faggioli, Gianluca, additional, Fernandes e Fernandes, Jose, additional, Fraedrich, Gustav, additional, Geroulakos, George, additional, Gloviczki, Peter, additional, Golledge, Jonathan, additional, Gupta, Ajay, additional, Jezovnik, Mateja K., additional, Kakkos, Stavros K., additional, Katsiki, Niki, additional, Knoflach, Michael, additional, Eline Kooi, M., additional, Lanza, Gaetano, additional, Lavenson, George S., additional, Liapis, Christos D., additional, Loftus, Ian M., additional, Mansilha, Armando, additional, Millon, Antoine, additional, Nicolaides, Andrew N., additional, Pini, Rodolfo, additional, Poredos, Pavel, additional, Proczka, Robert M., additional, Ricco, Jean-Baptiste, additional, Riles, Thomas S., additional, Ringleb, Peter Arthur, additional, Rundek, Tatjana, additional, Saba, Luca, additional, Schlachetzki, Felix, additional, Silvestrini, Mauro, additional, Spinelli, Francesco, additional, Stilo, Francesco, additional, Sultan, Sherif, additional, Suri, Jasjit S., additional, Svetlikov, Alexei V., additional, Zeebregts, Clark J., additional, and Chaturvedi, Seemant, additional

Published
2022
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46. Optimal management of asymptomatic carotid stenosis in 2021: the jury is still out. An international, multispecialty, expert review and position statement

Author

PARASKEVAS, Kosmas I., primary, MIKHAILIDIS, Dimitri P., additional, ANTIGNANI, Pier L., additional, BARADARAN, Hediyeh, additional, BOKKERS, Reinoud P.H., additional, CAMBRIA, Richard P., additional, DARDIK, Alan, additional, DAVIES, Alun H., additional, ECKSTEIN, Hans-Henning, additional, FAGGIOLI, Gianluca, additional, FERNANDES E FERNANDES, José, additional, FRAEDRICH, Gustav, additional, GEROULAKOS, George, additional, GLOVICZKI, Peter, additional, GOLLEDGE, Jonathan, additional, GUPTA, Ajay, additional, JEZOVNIK, Mateja K., additional, KAKKOS, Stavros K., additional, KATSIKI, Niki, additional, KNOFLACH, Michael, additional, KOOI, M. Eline, additional, LANZA, Gaetano, additional, LIAPIS, Christos D., additional, LOFTUS, Ian M., additional, MANSILHA, Armando, additional, MILLON, Antoine, additional, NICOLAIDES, Andrew N., additional, PINI, Rodolfo, additional, POREDOS, Pavel, additional, RICCO, Jean-Baptiste, additional, RILES, Thomas S., additional, RINGLEB, Peter Arthur, additional, RUNDEK, Tatjana, additional, SABA, Luca, additional, SCHLACHETZKI, Felix, additional, SILVESTRINI, Mauro, additional, SPINELLI, Francesco, additional, STILO, Francesco, additional, SULTAN, Sherif, additional, SURI, Jasjit S., additional, ZEEBREGTS, Clark J., additional, and CHATURVEDI, Seemant, additional

Published
2022
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47. Optimal Management of Asymptomatic Carotid Stenosis in 2021: The Jury is Still Out. An International, Multispecialty, Expert Review and Position Statement

Author

Paraskevas, Kosmas I. Mikhailidis, Dimitri P. Antignani, Pier Luigi Baradaran, Hediyeh Bokkers, Reinoud P. Cambria, Richard P. Dardik, Alan Davies, Alun H. Eckstein, Hans-Henning Faggioli, Gianluca Fernandes E Fernandes, Jose Fraedrich, Gustav Geroulakos, George Gloviczki, Peter Golledge, Jonathan Gupta, Ajay Jezovnik, Mateja K. Kakkos, Stavros K. Katsiki, Niki Knoflach, Michael Kooi, M. Eline Lanza, Gaetano Liapis, Christos D. Loftus, Ian M. Mansilha, Armando Millon, Antoine Nicolaides, Andrew N. Pini, Rodolfo Poredos, Pavel Ricco, Jean-Baptiste Riles, Thomas S. Ringleb, Peter Arthur Rundek, Tatjana Saba, Luca Schlachetzki, Felix Silvestrini, Mauro Spinelli, Francesco Stilo, Francesco Sultan, Sherif Suri, Jasjit S. Zeebregts, Clark J. Chaturvedi, Seemant

Abstract

Objectives: The recommendations of international guidelines for the management of asymptomatic carotid stenosis (ACS) often vary considerably and extend from a conservative approach with risk factor modification and best medical treatment (BMT) alone, to a more aggressive approach with a carotid intervention plus BMT. The aim of the current multispecialty position statement is to reconcile the conflicting views on the topic. Materials and methods: A literature review was performed with a focus on data from recent studies. Results: Several clinical and imaging high-risk features have been identified that are associated with an increased long-term ipsilateral ischemic stroke risk in patients with ACS. Such high-risk clinical/imaging features include intraplaque hemorrhage, impaired cerebrovascular reserve, carotid plaque echolucency/ulceration/ neovascularization, a lipid-rich necrotic core, a thin or ruptured fibrous cap, silent brain infarction, a contralateral transient ischemic attack/stroke episode, male patients < 75 years and microembolic signals on transcranial Doppler. There is growing evidence that 80-99% ACS indicate a higher stroke risk than 50-79% stenoses. Conclusions: Although aggressive risk factor control and BMT should be implemented in all ACS patients, several high-risk features that may increase the risk of a future cerebrovascular event are now documented. Consequently, some guidelines recommend a prophylactic carotid intervention in high-risk patients to prevent future cerebrovascular events. Until the results of the much-anticipated randomized controlled trials emerge, the jury is still out regarding the optimal management of ACS patients. (c) 2021 Elsevier Inc. All rights reserved.

Published
2022

48. Carotid endarterectomy or stenting or best medical treatment alone for moderate-to-severe asymptomatic carotid artery stenosis: 5-year results of a multicentre, randomised controlled trial

Author

Reiff, Tilman, Eckstein, Hans-Henning, Mansmann, Ulrich, Jansen, Olav, Fraedrich, Gustav, Mudra, Harald, Böckler, Dittmar, Böhm, Michael, Debus, E Sebastian, Fiehler, Jens, Mathias, Klaus, Ringelstein, Erich B, Schmidli, Jürg, Stingele, Robert, Zahn, Ralf, Zeller, Thomas, Niesen, Wolf-Dirk, Barlinn, Kristian, Binder, Andreas, Glahn, Jörg, Hacke, Werner, and Ringleb, Peter Arthur

Subjects
610 Medicine & health
Abstract

BACKGROUND The optimal treatment for patients with asymptomatic carotid artery stenosis is under debate. Since best medical treatment (BMT) has improved over time, the benefit of carotid endarterectomy (CEA) or carotid artery stenting (CAS) is unclear. Randomised data comparing the effect of CEA and CAS versus BMT alone are absent. We aimed to directly compare CEA plus BMT with CAS plus BMT and both with BMT only. METHODS SPACE-2 was a multicentre, randomised, controlled trial at 36 study centres in Austria, Germany, and Switzerland. We enrolled participants aged 50-85 years with asymptomatic carotid artery stenosis at the distal common carotid artery or the extracranial internal carotid artery of at least 70%, according to European Carotid Surgery Trial criteria. Initially designed as a three-arm trial including one group for BMT alone (with a randomised allocation ratio of 2·9:2·9:1), the SPACE-2 study design was amended (due to slow recruitment) to become two substudies with two arms each comparing CEA plus BMT with BMT alone (SPACE-2a) and CAS plus BMT with BMT alone (SPACE-2b); in each case in a 1:1 randomisation. Participants and clinicians were not masked to allocation. The primary efficacy endpoint was the cumulative incidence of any stroke or death from any cause within 30 days or any ipsilateral ischaemic stroke within 5 years. The primary safety endpoint was any stroke or death from any cause within 30 days after CEA or CAS. The primary analysis was by intention-to treat, which included all randomly assigned patients in SPACE-2, SPACE-2a, and SPACE-2b, analysed using meta-analysis of individual patient data. We did two-step hierarchical testing to first show superiority of CEA and CAS to BMT alone then to assess non-inferiority of CAS to CEA. Originally, we planned to recruit 3640 patients; however, the study had to be stopped prematurely due to insufficient recruitment. This report presents the primary analysis at 5-year follow-up. This trial is registered with ISRCTN, number ISRCTN78592017. FINDINGS 513 patients across SPACE-2, SPACE-2a, and SPACE-2b were recruited and surveyed between July 9, 2009, and Dec 12, 2019, of whom 203 (40%) were allocated to CEA plus BMT, 197 (38%) to CAS plus BMT, and 113 (22%) to BMT alone. Median follow-up was 59·9 months (IQR 46·6-60·0). The cumulative incidence of any stroke or death from any cause within 30 days or any ipsilateral ischaemic stroke within 5 years (primary efficacy endpoint) was 2·5% (95% CI 1·0-5·8) with CEA plus BMT, 4·4% (2·2-8·6) with CAS plus BMT, and 3·1% (1·0-9·4) with BMT alone. Cox proportional-hazard testing showed no difference in risk for the primary efficacy endpoint for CEA plus BMT versus BMT alone (hazard ratio [HR] 0·93, 95% CI 0·22-3·91; p=0·93) or for CAS plus BMT versus BMT alone (1·55, 0·41-5·85; p=0·52). Superiority of CEA or CAS to BMT was not shown, therefore non-inferiority testing was not done. In both the CEA group and the CAS group, five strokes and no deaths occurred in the 30-day period after the procedure. During the 5-year follow-up period, three ipsilateral strokes occurred in both the CAS plus BMT and BMT alone group, with none in the CEA plus BMT group. INTERPRETATION CEA plus BMT or CAS plus BMT were not found to be superior to BMT alone regarding risk of any stroke or death within 30 days or ipsilateral stroke during the 5-year observation period. Because of the small sample size, results should be interpreted with caution. FUNDING German Federal Ministry of Education and Research (BMBF) and German Research Foundation (DFG).

Published
2022
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