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32 results on '"Frachon, Irène"'

11. Mediator: une tragédie pour les victimes en deux actes

Author

Frachon, Irène, Univ, Réunion, and Hôpital de la Cavale Blanche - CHRU Brest (CHU - BREST )

Subjects
[SHS.DROIT]Humanities and Social Sciences/Law, [SHS.DROIT] Humanities and Social Sciences/Law, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018

12. Evaluation of a collaborative care program for pulmonary hypertension patients: a multicenter randomized trial.

Author

Roustit, Matthieu, Chaumais, Marie-Camille, Chapuis, Claire, Gairard-Dory, Anne, Hadjadj, Caroline, Chanoine, Sébastien, Allenet, Benoît, Sitbon, Olivier, Pison, Christophe, Bedouch, Pierrick, for the ETHAP Study Group, Dromer, Claire, Duconge, Séverine, Glavieux, Alan, Saux, Marie-Claude, Yeni, Sami, Demeyer, Christelle, Frachon, Irène, Lorillon, Philippe, and Bastin, Anne

Subjects
PULMONARY hypertension, CLINICAL trial registries, PATIENT compliance, PHARMACIST-patient relationships, MEDICATION errors, PREVENTION of drug side effects, PULMONARY hypertension treatment, RESEARCH, RESEARCH methodology, COOPERATIVENESS, MEDICAL cooperation, EVALUATION research, COMPARATIVE studies, RANDOMIZED controlled trials, HEALTH care teams, NURSES, HOSPITAL care, DRUG side effects, PHYSICIANS, LONGITUDINAL method
Abstract

Background Pulmonary hypertension is a rare, chronic and life-threatening group of diseases. Recent advances in pulmonary hypertension management prolong survival and improve quality-of-life. However, highly complex drug therapy enhances the risk of drug-related problems. Objective To assess the impact of involving clinical pharmacists in the collaborative care of pulmonary hypertension patients. Setting Ten French University Hospital Pneumology departments, all members of the French Network for Pulmonary Hypertension. Methods This prospective multicenter randomized controlled trial included incident pulmonary hypertension patients who were followed-up for 18 months. Randomization using an adapted Zelen method allocated patients to collaborative care (n = 41) or usual care groups (n = 51). A collaborative care program involving clinical pharmacists was developed through a close partnership between with physicians, nurses and pharmacists. Besides usual care, the program includes regular one-to-one interviews between the pharmacist and the patient. These interviews had following objectives: to perform an exhaustive medication history review; to identify the patient' needs, knowledge and skills; to define educational objectives and to provide patients with relevant information when needed. Following each interview, a standardized report form containing the pharmacist's recommendations was provided to physicians and nurses and discussed collaboratively. An ancillary economic analysis was performed. Main outcome measure Number of drug-related problems and their outcomes. Results The number of drug-related problems was not significantly different between groups (1.6 ± 1.5 vs. 1.9 ± 2.4; p = 0.41). More problems were resolved in the collaborative care group than in the usual care group (86.5% vs. 66.7%, p = 0.01). Time to clinical worsening, therapeutic adherence, satisfaction or quality-of-life were not statistically different between groups. Collaborative care decreased costs of drug-related hospitalizations. Conclusion Including clinical pharmacists in the multidisciplinary care of hospitalized patients with pulmonary hypertension improved the outcome of drug-related problems and reduced the costs of related hospitalization. However, we observed no efficacy on medication errors, clinical outcomes or medication adherence. Clinical Trial Registration ClinicalTrials.gov Identifier NCT01038284. [ABSTRACT FROM AUTHOR]

Published
2020
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14. Effets secondaires : le scandale français

Author

Béguin, Antoine, Brisard, Jean-Christophe, Frachon, Irène, Centre Jean Bodin : Recherche Juridique et Politique (CJB), Université d'Angers (UA), Groupe d'Etude de la Thrombose de Bretagne Occidentale (GETBO), Université de Brest (UBO)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Université de Brest (UBO), Département de Médecine Interne et Pneumologie [Brest] (DMIP - Brest), and Centre Hospitalier Régional Universitaire de Brest (CHRU Brest)

Subjects
Médicament (AMM), [SHS]Humanities and Social Sciences
Published
2015

15. [Letter on the article: 'benfluorex and valvular heart disease']

Author

Jobic, Yannick, Etienne, Yves, Tribouilloy, Christophe, Bruneval, Patrick, Frachon, Irène, Département de Cardiologie (CHRU - Cardio), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Mécanismes physiologiques et conséquences des calcifications cardiovasculaires: rôle des remodelages cardiovasculaires et osseux, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Picardie Jules Verne (UPJV), Groupe d'Etude de la Thrombose de Bretagne Occidentale (GETBO), Université de Brest (UBO)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Université de Brest (UBO), and Département de Médecine Interne et Pneumologie [Brest] (DMIP - Brest)

Subjects
MESH: Mitral Valve Insufficiency, MESH: Humans, MESH: Appetite Depressants, [SDV]Life Sciences [q-bio], MESH: Norfenfluramine, MESH: Aortic Valve Insufficiency, MESH: Female, ComputingMilieux_MISCELLANEOUS, MESH: Male, MESH: Fenfluramine
Abstract

International audience

Published
2012
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16. Survival in incident and prevalent cohorts of patients with pulmonary arterial hypertension

Author

Humbert, Marc, Sitbon, Olivier, Yaïci, A., Montani, D., O'Callaghan, D. S., Jaïs, X., Parent, F., Savale, L., Natali, D., Günther, S., Chaouat, A., Chabot, F., Cordier, J.-F., Habib, G., Gressin, V., Jing, Z.-C., Souza, R., Simonneau, Gerald, Frachon, Irène, Service de pneumologie [Béclère], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Antoine Béclère [Clamart], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre de résonance magnétique biologique et médicale (CRMBM), Assistance Publique - Hôpitaux de Marseille (APHM)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Service de pneumologie et Réanimation Respiratoire, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Bicêtre-DHU Thorax Innovation, Groupe d'Etude de la Thrombose de Bretagne Occidentale (GETBO), Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Université de Brest (UBO)-Université de Brest (UBO), Département de Médecine Interne et Pneumologie [Brest] (DMIP - Brest), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Brestois Santé Agro Matière (IBSAM), and Université de Brest (UBO)-Université de Brest (UBO)

Subjects
Pulmonary and Respiratory Medicine, Male, medicine.medical_specialty, Multivariate analysis, Hypertension, Pulmonary, [SDV]Life Sciences [q-bio], Physical exercise, 030204 cardiovascular system & hematology, MESH: Multivariate Analysis, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, MESH: Risk Factors, Internal medicine, medicine, Prevalence, Pulmonary Medicine, Humans, Familial Primary Pulmonary Hypertension, Risk factor, MESH: Cohort Studies, MESH: Pulmonary Medicine, MESH: Prevalence, Aged, MESH: Treatment Outcome, MESH: Aged, MESH: Humans, MESH: Middle Aged, MESH: Hypertension, Pulmonary, business.industry, Respiratory disease, Middle Aged, medicine.disease, Pulmonary hypertension, MESH: Male, 3. Good health, Surgery, medicine.anatomical_structure, Treatment Outcome, 030228 respiratory system, Cohort, Multivariate Analysis, Female, business, MESH: Female, Artery, Cohort study
Abstract

International audience; Pulmonary arterial hypertension (PAH) is a progressive, fatal disease. We studied 674 consecutive adult patients who were prospectively enrolled in the French PAH registry (121 incident and 553 prevalent cases). Two survival analyses were performed. First, the cohort of 674 patients was followed for 3 yrs after study entry and survival rates described. Then, we focused on the subset with incident idiopathic, familial and anorexigen-associated PAH (n = 56) combined with prevalent patients who were diagnosed

Published
2010
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17. [Pulmonary arterial hypertension in the elderly subject]

Author

Frachon, Irène, Barnier, Aude, Jobic, Yannick, Gut-Gobert, Christophe, Etienne, Yves, Crutu, Adrian, Mialon, Philippe, Pasquier, Elisabeth, Nowak, Emmanuel, Mejri, M., Couturaud, Francis, Leroyer, Christophe, Groupe d'Etude de la Thrombose de Bretagne Occidentale (GETBO), Université de Brest (UBO)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Université de Brest (UBO), Département de Médecine Interne et Pneumologie [Brest] (DMIP - Brest), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Département de Cardiologie (CHRU - Cardio), Centre d'Investigation Clinique (CIC - Brest), and Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Adult, Male, Cardiac Catheterization, Hypertension, Pulmonary, MESH: Comorbidity, Comorbidity, MESH: Prognosis, Cohort Studies, Young Adult, MESH: Aged, 80 and over, MESH: Pulmonary Wedge Pressure, Natriuretic Peptide, Brain, Humans, MESH: Natriuretic Peptide, Brain, Pulmonary Wedge Pressure, MESH: Peptide Fragments, MESH: Cohort Studies, Aged, MESH: Age Factors, MESH: Aged, Aged, 80 and over, MESH: Humans, MESH: Middle Aged, MESH: Hypertension, Pulmonary, Age Factors, MESH: Adult, Middle Aged, Prognosis, MESH: Male, MESH: Heart Catheterization, Peptide Fragments, MESH: France, MESH: Young Adult, Exercise Test, Female, France, MESH: Exercise Test, MESH: Female, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; OBJECTIVE: To describe the features of pulmonary arterial hypertension (PAH) in elderly patients. METHODS: A single centre, descriptive study of PAH patients consecutively referred to a regional centre, from September 2002 to February, 1st, 2009. The group of patients aged 65 and above at the time of the diagnosis was compared to the younger patients. RESULTS: Sixty-six patients suffering from PAH (group 1) have been investigated by means of right heart catheterisation. There were 24 patients aged 65 and above. Mean pulmonary arterial pressure was lower in the patients aged over 65. The older patient group had more respiratory and/or cardiac co-morbidities, a lower median distance in the 6minute walk test and a higher median Pro-BNP level. Specific PAH treatments were prescribed in both groups. Fifteen patients aged 65 and above were on long-term oxygen therapy (vs four younger patients, p

Published
2009
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19. [Diagnosis and care of postembolic pulmonary hypertension: the role of the pneumologist]

Author

Frachon, Irène, Jaïs, X., Leroyer, Christophe, Jobic, Yannick, Huchot, Eric, Simonneau, Gérald, Dartevelle, Philippe, Groupe d'Etude de la Thrombose de Bretagne Occidentale (GETBO), Université de Brest (UBO)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Université de Brest (UBO), Département de Médecine Interne et Pneumologie [Brest] (DMIP - Brest), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Département de Cardiologie (CHRU - Cardio), Centre National de Référence de l'Hypertension Artérielle Pulmonaire (UPRES - EA2705), and Université Paris-Sud - Paris 11 (UP11)

Subjects
MESH: Angiography, MESH: Pulmonary Embolism, MESH: Humans, MESH: Hypertension, Pulmonary, Hypertension, Pulmonary, Patient Selection, Angiography, Endarterectomy, MESH: Endarterectomy, Humans, MESH: Patient Selection, MESH: Tomography, Spiral Computed, Pulmonary Embolism, Tomography, Spiral Computed, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; The prognosis of postembolic pulmonary hypertension, a rare and serious disease, has been transformed with the curative intervention of pulmonary endarteriectomy. The screening is based on two key non invasive examinations, the cardiac ultrasound and ventilation-perfusion scintigraphy. The confirmation of the diagnosis and the determination of the best therapeutic options then relies on the expertise of the national reference centre, based on the haemodynamics and the morphological data provided by pulmonary angiography and spiral computerised tomography. Although the technique of endarteriectomy is fully validated, a drug approach is in the assessment process, both in the inoperable forms or when confronted with persistent postsurgical pulmonary hypertension.

Published
2008
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20. L'HTAP en questions

Author

Frachon, Irène, Calvez, Ghislaine, Groupe d'Etude de la Thrombose de Bretagne Occidentale (GETBO), Université de Brest (UBO)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Université de Brest (UBO), Département de Médecine Interne et Pneumologie [Brest] (DMIP - Brest), and Centre Hospitalier Régional Universitaire de Brest (CHRU Brest)

Subjects
[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Published
2007

22. T-cell Therapy Using a Bank of EBV-specific Cytotoxic T Cells

Author

Gallot, Géraldine, primary, Vollant, Solène, additional, Saïagh, Soraya, additional, Clémenceau, Béatrice, additional, Vivien, Régine, additional, Cerato, Evelyne, additional, Bignon, Jean-D., additional, Ferrand, Christophe, additional, Jaccard, Arnaud, additional, Vigouroux, Stéphane, additional, Choquet, Sylvain, additional, Dalle, Jean-Hugues, additional, Frachon, Irène, additional, Bruno, Bénédicte, additional, Mothy, Mohamad, additional, Mechinaud, Françoise, additional, Leblond, Véronique, additional, Milpied, Noël, additional, and Vié, Henri, additional

Published
2014
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23. Pulmonary hypertension associated with benfluorex exposure

Author

Savale, Laurent, primary, Chaumais, Marie-Camille, additional, Cottin, Vincent, additional, Bergot, Emmanuel, additional, Frachon, Irène, additional, Prevot, Grégoire, additional, Pison, Christophe, additional, Dromer, Claire, additional, Poubeau, Patrice, additional, Lamblin, Nicolas, additional, Habib, Gilbert, additional, Reynaud-Gaubert, Martine, additional, Bourdin, Arnaud, additional, Sanchez, Olivier, additional, Tubert-Bitter, Pascale, additional, Jaïs, Xavier, additional, Montani, David, additional, Sitbon, Olivier, additional, Simonneau, Gérald, additional, and Humbert, Marc, additional

Published
2012
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