Search

Your search keyword '"Frøkiær, Jørgen"' showing total 1,099 results
Start Over Author "Frøkiær, Jørgen"
1,099 results on '"Frøkiær, Jørgen"'

3. Risk factors for kidney scarring and vesicoureteral reflux in 421 children after their first acute pyelonephritis, and appraisal of international guidelines

Author

Breinbjerg, Anders, Jørgensen, Cecilie Siggaard, Frøkiær, Jørgen, Tullus, Kjell, Kamperis, Konstantinos, and Rittig, Søren

Subjects
Urinary tract infections -- Demographic aspects -- Patient outcomes, Pyelonephritis -- Complications and side effects, Bladder diseases -- Risk factors, Kidney diseases -- Risk factors, Health
Abstract

Background Acute pyelonephritis (AP) is a common bacterial infection in childhood. Follow-up guidelines on these children are controversial. This study aimed to identify risk factors for kidney scarring and vesicoureteral reflux (VUR). Furthermore, international follow-up guidelines were used for simulation to evaluate sensitivity and specificity. Methods Urinary culture-confirmed first-time AP patients (aged 0-14 years) were enrolled (n = 421) from review of patient charts. All underwent kidney ultrasound (US) and a technetium-99m-dimercaptosuccinic acid (DMSA) scan or technetium-99m-mercaptoacetyltriglycine scinti-renography (MAG3) at 4-6 months of follow-up. The international guidelines used for simulation were from the National Institute of Health UK (NICE), the American Association of Paediatrics (AAP) and the Swedish Paediatric Society (SPS). Results 17.8% presented with an abnormal DMSA/MAG3 at follow-up, 7.1% were diagnosed with VUR grades III-V and 4.7% were admitted for surgery. Non-Escherichia coli infections, abnormal kidney US, elevated creatinine and delayed response to treatment (>48 h) were risk factors for abnormal DMSA findings and VUR grades III-V. NICE and SPS guidelines showed best sensitivity in diagnosing VUR grades III-V (75%) compared with AAP (56%). Conclusions Risk factors are helpful in identifying the children in need of further investigations and minimizing invasive work-up for the rest. International guidelines on follow-up detect a varying number of children with kidney damage and/or significant VUR. Future work must focus on identifying more specific risk factors, better imaging, or specific biomarkers, to enhance sensitivity and specificity in detecting the children at high risk for developing recurrent infections and/or nephropathy., Author(s): Anders Breinbjerg [sup.1] , Cecilie Siggaard Jørgensen [sup.1] , Jørgen Frøkiær [sup.2] , Kjell Tullus [sup.3] , Konstantinos Kamperis [sup.1] , Søren Rittig [sup.1] Author Affiliations: (1) grid.154185.c, 0000 [...]

Published
2021
Full Text
View/download PDF

20. Treatment with a human recombinant monoclonal IgG antibody against oxidized LDL in atherosclerosis-prone pigs reduces cathepsin S in coronary lesions

Author

Poulsen, Christian Bo, Al-Mashhadi, Ahmed Ludvigsen, von Wachenfeldt, Karin, Bentzon, Jacob Fog, Nielsen, Lars Bo, Al-Mashhadi, Rozh H., Thygesen, Jesper, Tolbod, Lars, Larsen, Jens Rolighed, Frøkiær, Jørgen, Tawakol, Ahmed, Vucic, Esad, Fredrickson, Jill, Baruch, Amos, Frendéus, Björn, Robertson, Anna-Karin L., Moestrup, Søren Kragh, Drouet, Ludovic, and Falk, Erling

Published
2016
Full Text
View/download PDF

26. The Probe for Renal Organic Cation Secretion (4-Dimethylaminostyryl)-N-Methylpyridinium (ASP+)) Shows Amplified Fluorescence by Binding to Albumin and Is Accumulated In Vivo.

Author

Engbjerg, Jacob Schade, Costanzo, Vincenzo, Sardella, Donato, Bordoni, Luca, Jakobsen, Steen, D'Apolito, Luciano, Frøkiær, Jørgen, Trepiccione, Francesco, Capasso, Giovambattista, Frische, Sebastian, and Akers, Walter

Subjects
POSITRON emission tomography, PROXIMAL kidney tubules, FLUORESCENCE, ALBUMINS, BIOLOGICAL transport, SECRETION, SERUM albumin
Abstract

Accumulation of uremic toxins may lead to the life-threatening condition "uremic syndrome" in patients with advanced chronic kidney disease (CKD) requiring renal replacement therapy. Clinical evaluation of proximal tubular secretion of organic cations (OC), of which some are uremic toxins, is desired, but difficult. The biomedical knowledge on OC secretion and cellular transport partly relies on studies using the fluorescent tracer 4-dimethylaminostyryl)- N -methylpyridinium (ASP+), which has been used in many studies of renal excretion mechanisms of organic ions and which could be a candidate as a PET tracer. This study is aimed at expanding the knowledge of the tracer characteristics of ASP+ by recording the distribution and intensity of ASP+ signals in vivo both by fluorescence and by positron emission tomography (PET) imaging and at investigating if the fluorescence signal of ASP+ is influenced by the presence of albumin. Two-photon in vivo microscopy of male Münich Wistar Frömter rats showed that a bolus injection of ASP+ conferred a fluorescence signal to the blood plasma lasting for about 30 minutes. In the renal proximal tubule, the bolus resulted in a complex pattern of fluorescence including a rapid and strong transient signal at the brush border, a very low signal in the luminal fluid, and a slow transient intracellular signal. PET imaging using 11C-labelled ASP+ showed accumulation in the liver, heart, and kidney. Fluorescence emission spectra recorded in vitro of ASP+ alone and in the presence of albumin using both 1-photon excitation and two-photon excitation showed that albumin strongly enhance the emission from ASP+ and induce a shift of the emission maximum from 600 to 570 nm. Conclusion. The renal pattern of fluorescence observed from ASP+ in vivo is likely affected by the local concentration of albumin, and quantification of ASP+ fluorescent signals in vivo cannot be directly translated to ASP+ concentrations. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

30. Aquaporins in the Kidney

Author

Kwon, Tae-Hwan, Nielsen, Jakob, Møller, Hanne B., Fenton, Robert A., Nielsen, Søren, Frøkiær, Jørgen, Hofmann, F., editor, and Beitz, Eric, editor

Published
2009
Full Text
View/download PDF

38. Myocardial efficiency in patients with different aetiologies and stages of heart failure

Author

Berg Hansen, Kristoffer, Sörensen, Jens, Hansson, Nils Henrik, Nielsen, Roni, Larsen, Anders Hostrup, Frøkiaer, Jørgen, Tolbod, Lars Poulsen, Gormsen, Lars Christian, Harms, Hendrik Johannes, Wiggers, Henrik, Berg Hansen, Kristoffer, Sörensen, Jens, Hansson, Nils Henrik, Nielsen, Roni, Larsen, Anders Hostrup, Frøkiaer, Jørgen, Tolbod, Lars Poulsen, Gormsen, Lars Christian, Harms, Hendrik Johannes, and Wiggers, Henrik

Abstract

Aims: Myocardial external efficiency (MEE) is the ratio of cardiac work in relation with energy expenditure. We studied MEE in patients with different aetiologies and stages of heart failure (HF) to discover the role and causes of deranged MEE. In addition, we explored the impact of patient characteristics such as sex, body mass index (BMI), and age on myocardial energetics. Methods and results: Cardiac energetic profiles were assessed with C-11-acetate positron emission tomography (PET) and left ventricular ejection fraction (LVEF) was acquired with echocardiography. MEE was studied in 121 participants: healthy controls (n = 20); HF patients with reduced (HFrEF; n = 25) and mildly reduced (HFmrEF; n = 23) LVEF; and patients with asymptomatic (AS-asymp; n = 38) and symptomatic (AS-symp; n = 15) aortic stenosis (AS). Reduced MEE coincided with symptoms of HF irrespective of aetiology and declined in tandem with deteriorating LVEF. Patients with AS-symp and HFmrEF had reduced MEE as compared with controls (22.2 +/- 4.9%, P = 0.041 and 20.0 +/- 4.2%, P < 0.001 vs. 26.1 +/- 5.8% in controls) and a further decline was observed in patients with HFrEF (14.7 +/- 6.3%, P < 0.001). Disproportionate left ventricular hypertrophy was a major cause of reduced MEE. Female sex (P < 0.001), a lower BMI (P = 0.001), and advanced age (P = 0.03) were associated with a lower MEE. Conclusion: MEE was reduced in patients with HFrEF, HFmrEF, and HF due to pressure overload and MEE may therefore constitute a treatment target in HF. Patients with LVH, advanced age, female sex, and low BMI had more pronounced reduction in MEE and personalized treatment within these patient subgroups could be relevant.

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results