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1,008 results on '"Fowler, Daniel"'

1. High-dose alemtuzumab and cyclosporine vs tacrolimus, methotrexate, and sirolimus for chronic graft-versus-host disease prevention

Author

Holtzman, Noa G., Curtis, Lauren M., Salit, Rachel B., Shaffer, Brian C., Pirsl, Filip, Ostojic, Alen, Steinberg, Seth M., Schulz, Eduard, Wilder, Jennifer S., Hughes, Thomas E., Rose, Jeremy, Memon, Sarfraz, Korngold, Robert, Gea-Banacloche, Juan C., Fowler, Daniel H., Hakim, Frances T., Gress, Ronald E., Bishop, Michael R., and Pavletic, Steven Z.

Published
2024
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3. 'Zooming in' on Polymer Chemistry and Designing Synthesis of High Sulfur-Content Polymers for Virtual Undergraduate Laboratory Experiment

Author

Karayilan, Metin, Vakil, Jafer, Fowler, Daniel, Becker, Matthew L., and Cox, Charles T.

Abstract

Polymer chemistry is essential within chemical education because of its applications in academic and industrial research, materials science, and across engineering disciplines. Teaching polymer chemistry principles early on in the undergraduate curriculum allows students to find connections between chemistry and real-world applications and can promote interest in science and scientific research. Performing laboratory experiments on polymers is of equal importance when integrating polymer concepts into undergraduate-level lectures. There are several widely utilized lab demonstrations on polymer synthesis, characterization, and applications, yet more, easy-to-handle experiments are needed that connect polymers to organic reactions, spectroscopy, and sustainability, especially in a virtual setting. This virtual experiment was designed to incorporate the synthesis of high sulfur-content polymers into the general chemistry laboratory during the pandemic. Teaching assistants (TAs) performed the experiments and collected the necessary data and observations for students. Video recordings of the polymerization reactions, reaction times, and collages of digital images depicting reaction progress (viscosity and color changes) are provided to students. During a single 2-3-h virtual lab meeting, students watch the lab videos, read the student handout and a research paper, and discuss the results and observations with their peers and lab TAs. The lab experiment demonstrates the interdependence of general chemistry learning objectives including chemical bonding, radicals, reaction kinetics, thermodynamics, stoichiometric calculations, and spectroscopy. In addition, this virtual experiment introduces undergraduate students to polymer chemistry, encourages them to look beyond the textbooks and lecture resources by using literature articles, and connects general chemistry concepts with upper-level chemistry classes. Post lab survey results show that students find the video recordings and group discussions on the polymerization reactions very helpful in understanding a new concept within a virtual distant-learning environment.

Published
2021
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4. A fuzz testing methodology for cyber-security assurance of the automotive CAN bus

Author

Fowler, Daniel S., Bryans, Jeremy, and Shaikh, Siraj

Subjects
629.22028
Abstract

The cyber-physical vehicle is one of the underpinnings of modern society, however, if a vehicle's design is faulty it carries a risk of injury to the occupants and the public. It has been demonstrated that intelligent agents can penetrate connected cars via cyber attacks and cause an unsafe state. The possibility of a cyber attack means that cyber-security testing should be performed to maintain assurance in vehicle systems. However, vehicle cyber-security testing methods are immature. Fuzz testing is a dynamic testing method for software-based systems. Automotive industry guidelines regard it as a component in the security testing process of cyber-physical systems. The hypothesis is that fuzz testing can be used over a system's lifecycle as part of the design and maintenance process for cyber-security. However, there are few evidential results on the application of fuzz testing to the automotive field. This applied research provides one of, if not the first, detailed contribution on fuzz testing automotive systems. A tool to performing vehicle fuzz testing, called a fuzzer, was constructed using an iterative methodology to enable experimental observations on automotive systems and components. Using the dedicated fuzzer empirical results were gathered. The target for the fuzz testing was a lab vehicle's Electronic Control Units, accessed via a common intra-vehicular communications bus, the Controller Area Network. The results demonstrate that fuzz testing is indeed beneficial to the design of vehicle systems and can contribute to system assurance. Furthermore, the construction of the fuzzer and its application to vehicle systems has contributed a method for the development of additional security tests for the automotive field. However, the technology within a vehicle system is a challenge for cyber-security testing, this includes the cyber-physical aspects of a car and the symbiotic interaction of a vehicle's computational elements. There remains significant research work required before fuzz testing becomes commonly integrated into test procedures for all the systems within connected cars.

Published
2019

5. Payload-delivering engineered γδ T cells display enhanced cytotoxicity, persistence, and efficacy in preclinical models of osteosarcoma

Author

Fowler, Daniel, primary, Barisa, Marta, additional, Southern, Alba, additional, Nattress, Callum, additional, Hawkins, Elizabeth, additional, Vassalou, Eleni, additional, Kanouta, Angeliki, additional, Counsell, John, additional, Rota, Enrique, additional, Vlckova, Petra, additional, Draper, Benjamin, additional, De Mooij, Tessa, additional, Farkas, Andrea, additional, Brezovjakova, Helena, additional, Baker, Alfie T., additional, Scotlandi, Katia, additional, Manara, Maria C., additional, Tape, Chris, additional, Chester, Kerry, additional, Anderson, John, additional, and Fisher, Jonathan, additional

Published
2024
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7. High-dose Alemtuzumab-Cyclosporine vs Tacrolimus-Methotrexate-Sirolimus for Chronic Graft-versus-Host Disease Prevention

Author

Holtzman, Noa G., primary, Curtis, Lauren M, additional, Salit, Rachel B, additional, Shaffer, Brian C, additional, Pirsl, Filip, additional, Ostojic, Alen, additional, Steinberg, Seth M, additional, Schulz, Eduard, additional, Wilder, Jennifer S., additional, Hughes, Thomas E, additional, Rose, Jeremy, additional, Memon, Sarfraz, additional, Korngold, Robert, additional, Gea-Banacloche, Juan, additional, Fowler, Daniel H, additional, Hakim, Frances T, additional, Gress, Ronald E., additional, Bishop, Michael R., additional, and Pavletic, Steven Z, additional

Published
2024
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9. Prospective Study of a Novel, Radiation-Free, Reduced-Intensity Bone Marrow Transplantation Platform for Primary Immunodeficiency Diseases

Author

Dimitrova, Dimana, Gea-Banacloche, Juan, Steinberg, Seth M., Sadler, Jennifer L., Hicks, Stephanie N., Carroll, Ellen, Wilder, Jennifer S., Parta, Mark, Skeffington, Lauren, Hughes, Thomas E., Blau, Jenny E., Broadney, Miranda M., Rose, Jeremy J., Hsu, Amy P., Fletcher, Rochelle, Nunes, Natalia S., Yan, Xiao-Yi, Telford, William G., Kapoor, Veena, Cohen, Jeffrey I., Freeman, Alexandra F., Garabedian, Elizabeth, Holland, Steven M., Lisco, Andrea, Malech, Harry L., Notarangelo, Luigi D., Sereti, Irini, Shah, Nirali N., Uzel, Gulbu, Zerbe, Christa S., Fowler, Daniel H., Gress, Ronald E., Kanakry, Christopher G., and Kanakry, Jennifer A.

Published
2020
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12. 723 Metabolically reprogrammed autologous Th1/Tc1 cell therapy (RAPA-201) yields promising safety and efficacy in post-PD-(L)1 solid tumor patients without lymphodepleting host conditioning

Author

Gutierrez, Martin, primary, Donato, Michele, additional, Reich-Slotky, Ronit, additional, Patel, Sunil, additional, Finlay, Morgan, additional, Coordinator, Research Nurse, additional, Lum, Lawrence G, additional, Park, Jee Hyun, additional, Felizardo, Tania, additional, and Fowler, Daniel H, additional

Published
2023
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13. Lentivirus-mediated gene therapy for Fabry disease

Author

Khan, Aneal, Barber, Dwayne L., Huang, Ju, Rupar, C. Anthony, Rip, Jack W., Auray-Blais, Christiane, Boutin, Michel, O’Hoski, Pamela, Gargulak, Kristy, McKillop, William M., Fraser, Graeme, Wasim, Syed, LeMoine, Kaye, Jelinski, Shelly, Chaudhry, Ahsan, Prokopishyn, Nicole, Morel, Chantal F., Couban, Stephen, Duggan, Peter R., Fowler, Daniel H., Keating, Armand, West, Michael L., Foley, Ronan, and Medin, Jeffrey A.

Published
2021
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14. Characterization of Hepatic Dysfunction in Subjects Diagnosed With Chronic GVHD by NIH Consensus Criteria

Author

Yang, Alexander H., Han, Ma Ai Thanda, Samala, Niharika, Rizvi, Bisharah S., Marchalik, Rachel, Etzion, Ohad, Wright, Elizabeth C., Cao, Liang, Hakim, Frances T., Jones, Elizabeth, Kapuria, Devika, Hickstein, Dennis D., Fowler, Daniel, Kanakry, Jennifer A., Kanakry, Christopher G., Kleiner, David E., Koh, Christopher, Pavletic, Steven Z., and Heller, Theo

Published
2022
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17. The anti-tumour immune responses of γδ T cells activated with BCG, M. vaccae and M. obuense

Author

Fowler, Daniel William

Subjects
616.994079
Abstract

Introduction: BCG and heat-killed M. vaccae and M. obuense are currently being used as cancer immunotherapeutic agents; however, the induced immune response is poorly characterised and potential biomarkers of response ill-defined. γδ T cells have recently emerged as key players in immunity against both bacterial infections and malignant transformations, yet their role in cancer immunotherapies such as BCG, M. vaccae and M. obuense has been largely over-looked. This project investigates whether these three bacterial preparations can elicit anti-tumour responses in human peripheral blood γδ T cells. Methods: In this thesis, in vitro proof-of-concept experiments were conducted on human peripheral blood γδ T cells in order to test the activatory capacity of BCG, M. vaccae and M. obuense. To determine whether γδ T cells are activated by these bacterial preparations, activation marker expression and proliferation responses were assessed. Furthermore, the anti-tumour responses were also investigated by measuring cytokine production, expression of granzyme B and cytotoxicity against tumour target cells. In addition, the mechanism by which BCG, M. vaccae and M. obuense can activate these γδ T cell responses was assessed. Results: Results show that γδ T cells are activated by these three bacterial preparations, as suggested by upregulation of activation marker expression and proliferation responses. It was found that γδ T cells produce the T H1 cytokines IFN-y and TNF-a, and upregulate granzyme B expression, which correlates with an enhanced capacity to kill Daudi target cells and zoledronate-treated A549 cells. Results also suggest that γδ T cell responses are induced by IL-12, IL-1~ and TNF-a from a subpopulation of peripheral blood myeloid dendritic cells, and that M. obuense- but not BCG- or M. vaccae-induced cytokine production by these cells is, at least in part, dependent on TLR2 signalling. Conclusion: Taken together, data suggest a potential mechanism for the anti-cancer effects of BCG, M. vaccae and M. obuense, which could ultimately guide clinicians in harnessing the full potential of these bacterial preparations in cancer immunotherapy.

Published
2011

19. Impact of the 2014 NIH chronic graft-versus-host disease scoring criteria modifications assessed in a large cohort of severely affected patients

Author

Kerep, Ana Zelic, Broome, Jacob, Pirsl, Filip, Curtis, Lauren M., Steinberg, Seth M., Mitchell, Sandra A., Cowen, Edward W., Pichard, Dominique C., Joe, Galen O., Comis, Leora E., Mays, Jacqueline W., Datiles, III, Manuel B., Stratton, Pamela, Zolton, Jessica, Berger, Ann, Hendricks, Jennifer, Kenyon, Megan, Baruffaldi, Judy, Titarenko, Irina, Pulanic, Drazen, Baird, Kristin, Fowler, Daniel H., Gress, Ronald E., and Pavletic, Steven Z.

Published
2019
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22. The Biology of Chronic Graft-versus-Host Disease: A Task Force Report from the National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease

Author

Cooke, Kenneth R., Luznik, Leo, Sarantopoulos, Stefanie, Hakim, Frances T., Jagasia, Madan, Fowler, Daniel H., van den Brink, Marcel R.M., Hansen, John A., Parkman, Robertson, Miklos, David B., Martin, Paul J., Paczesny, Sophie, Vogelsang, Georgia, Pavletic, Steven, Ritz, Jerome, Schultz, Kirk R., and Blazar, Bruce R.

Published
2017
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24. A Practical Implementation of Quantum-Derived Keys for Secure Vehicle-to-Infrastructure Communications.

Author

Fowler, Daniel S., Maple, Carsten, and Epiphaniou, Gregory

Subjects
COMPUTER software security, SYSTEMS design, QUANTUM computers
Abstract

We provide a practical implementation of a free space optical quantum key distribution (FSO-QKD) system within a vehicle-to-infrastructure (V2I) application developed under the Innovate UK AirQKD project. The FSO-QKD system provides the quantum secure encryption keys that serve as the foundation for secure communications throughout the V2I application to address known concerns over V2I security. This document includes summaries of the quantum key generation process and the deployed V2I technology. Subsequently, a high-level view of the system design, the practical experiment, and its execution are presented. Multiple AirQKD project partners developed technologies ranging from semiconductors and hardware to security protocols and software, to enable the QKD-secured V2I system. The developed technology includes a novel zero-trust security protocol used to protect the V2I communications, ensuring that spoofed V2I messages from a compromised device are not accepted by the system. [ABSTRACT FROM AUTHOR]

Published
2023
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25. Secular trends in the utility of SGLT‐2 inhibitors in heart failure patients with type 2 diabetes mellitus across Metro South Health hospitals in South‐East Queensland.

Author

Lu, Zhen Qi, McCourt, Elizabeth, Goodhew, Karen, Gupta, Deepali, Chuan, Francine, Mok, Leonie, Peters, Robyn, Ha, Tina, Fowler, Daniel, Dobbyn, Daniel Michael, Hetherington, Justine, Challa, Prasad, Kannan, Shanthi, Korczyk, Dariusz, Russell, Anthony, and Mugwagwa, Augustine Nyasha

Subjects
HOSPITALS, GLOMERULAR filtration rate, RETROSPECTIVE studies, TYPE 2 diabetes, MEDICAL protocols, COMPARATIVE studies, DESCRIPTIVE statistics, DRUG prescribing, SODIUM-glucose cotransporter 2 inhibitors, DRUG utilization, PHYSICIAN practice patterns, HEART failure, PATIENT safety
Abstract

Background: The 2018 Australian Heart Failure (HF) guidelines strongly recommended commencing sodium‐glucose co‐transporter‐2 inhibitors (SGLT‐2is) in HF patients with type 2 diabetes mellitus (T2DM). The uptake of SGLT‐2is for HF patients with T2DM in our health service is unknown. Aims: To determine the adoption of the 2018 HF guidelines by assessing the temporal trends of SGLT‐2is' usage in HF patients with T2DM at Metro South Health (MSH) hospitals, in South‐East Queensland. Methods: Retrospective analysis of all HF patients (ejection fraction (EF) < 50%) with T2DM who were managed within MSH hospitals between June 2018 and June 2021. Results: A total of 666 patients met the inclusion criteria with 918 HF encounters. Mean age was 72 years and 71% were male (473/666). Mean EF was 30% (SD ± 11%), and mean estimated glomerular filtration rate was 48 mL/min/1.73 m2 (SD ± 25). Fifty‐four per cent (362/666) had contraindications to SGLT‐2is. Among those without contraindications, there was a five‐fold increase in the utility of SGLT‐2is, 7% (2/29) before versus 38% (103/275) after implementation of the HF guidelines (P < 0.001). Patients on SGLT‐2is were younger (64 years vs 69 years, P = 0.002) and had a lower number of HF hospitalisations (1.1 vs 2.1, P = 0.01). Conclusions: During the study period, 54% of our HF patients with T2DM were not on SGLT‐2is due to prescribing guidelines/limitations in the Australian context. We observed a five‐fold significant increase in the uptake of SGLT‐2is before and after implementation of HF guidelines among patients without contraindications to SGLT‐2is. There were significantly fewer HF hospitalisations among patients on SGLT‐2is compared to those without. [ABSTRACT FROM AUTHOR]

Published
2023
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27. Contributors

Author

Aguilar, Ethan George, primary, Alatrash, Gheath, additional, Anasetti, Claudio, additional, Arvindam, Upasana Sunil, additional, Blazar, Bruce R., additional, Bousso, Philippe, additional, Byersdorfer, Craig, additional, Chilkulwar, Abhishek R., additional, Coghill, James M., additional, Cooke, Kenneth R., additional, Crain, Alyssa K., additional, Drobyski, William R., additional, Dudakov, Jarrod A., additional, Edinger, Matthias, additional, Felices, Martin, additional, Fry, Terry J., additional, Fowler, Daniel H., additional, Goulmy, Els, additional, Hanash, Alan M., additional, Hill, Geoffrey R., additional, Hoffmann, Petra, additional, Holler, Ernst, additional, Holtan, Shernan, additional, Jacoby, Elad, additional, Jenq, Robert R., additional, Kean, Leslie, additional, Levy, Robert B., additional, Markey, Kate A., additional, Martin, Paul J., additional, Michonneau, David, additional, Miller, Jeffrey, additional, Molldrem, Jeffrey J., additional, Murphy, William, additional, Mutis, Tuna, additional, Negrin, Robert S., additional, Paczesny, Sophie, additional, Penack, Olaf, additional, Petersdorf, Effie, additional, Piper, Clint, additional, Reddy, Pavan, additional, Ritz, Jerome, additional, Sarantopoulos, Stefanie, additional, Serody, Jonathan S., additional, Socié, Gérard, additional, Takashima, Shuichiro, additional, van den Brink, Marcel R.M., additional, Weber, Daniela, additional, Wu, Yongxia, additional, Yu, Xue-Zhong, additional, and Zeiser, Robert, additional

Published
2019
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30. Data from Phase I Trial of Adoptive Cell Transfer with Mixed-Profile Type-I/Type-II Allogeneic T Cells for Metastatic Breast Cancer

Author

Hardy, Nancy M., primary, Mossoba, Miriam E., primary, Steinberg, Seth M., primary, Fellowes, Vicki, primary, Yan, Xiao-Yi, primary, Hakim, Frances T., primary, Babb, Rebecca R., primary, Avila, Daniele, primary, Gea-Banacloche, Juan, primary, Sportès, Claude, primary, Levine, Bruce L., primary, June, Carl H., primary, Khuu, Hahn M., primary, Carpenter, Ashley E., primary, Krumlauf, Michael C., primary, Dwyer, Andrew J., primary, Gress, Ronald E., primary, Fowler, Daniel H., primary, and Bishop, Michael R., primary

Published
2023
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31. Supplementary Table 1 from Phase I Trial of Adoptive Cell Transfer with Mixed-Profile Type-I/Type-II Allogeneic T Cells for Metastatic Breast Cancer

Author

Hardy, Nancy M., primary, Mossoba, Miriam E., primary, Steinberg, Seth M., primary, Fellowes, Vicki, primary, Yan, Xiao-Yi, primary, Hakim, Frances T., primary, Babb, Rebecca R., primary, Avila, Daniele, primary, Gea-Banacloche, Juan, primary, Sportès, Claude, primary, Levine, Bruce L., primary, June, Carl H., primary, Khuu, Hahn M., primary, Carpenter, Ashley E., primary, Krumlauf, Michael C., primary, Dwyer, Andrew J., primary, Gress, Ronald E., primary, Fowler, Daniel H., primary, and Bishop, Michael R., primary

Published
2023
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36. Haploidentical transplant with posttransplant cyclophosphamide vs matched unrelated donor transplant for acute myeloid leukemia

Author

Ciurea, Stefan O., Zhang, Mei-Jie, Bacigalupo, Andrea A., Bashey, Asad, Appelbaum, Frederick R., Aljitawi, Omar S., Armand, Philippe, Antin, Joseph H., Chen, Junfang, Devine, Steven M., Fowler, Daniel H., Luznik, Leo, Nakamura, Ryotaro, O'Donnell, Paul V., Perales, Miguel-Angel, Pingali, Sai Ravi, Porter, David L., Riches, Marcie R., Ringdén, Olle T.H., Rocha, Vanderson, Vij, Ravi, Weisdorf, Daniel J., Champlin, Richard E., Horowitz, Mary M., Fuchs, Ephraim J., and Eapen, Mary

Published
2015
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37. Secular trends in the utility of SGLT ‐2 inhibitors in heart failure patients with type 2 diabetes mellitus across Metro South Health hospitals in South‐East Queensland

Author

Lu, Zhen Qi, primary, McCourt, Elizabeth, additional, Goodhew, Karen, additional, Gupta, Deepali, additional, Chuan, Francine, additional, Mok, Leonie, additional, Peters, Robyn, additional, Ha, Tina, additional, Fowler, Daniel, additional, Dobbyn, Daniel Michael, additional, Hetherington, Justine, additional, Challa, Prasad, additional, Kannan, Shanthi, additional, Korczyk, Dariusz, additional, Russell, Anthony, additional, and Mugwagwa, Augustine Nyasha, additional

Published
2022
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39. 568 Balls in the Air: Planning for the Loss of Space Capabilities

Author

Igl, Chadwick D., Smith, Candy S., Fowler, Daniel R., and Angermann, William L.

Subjects
United States. Department of Defense, United States. Strategic Command, United States. Air Force, Satellites (Spacecraft) -- Military aspects, Military and naval science
Abstract

An event of considerable technical and scientific importance ... [its] importance should not be exaggerated ... the value of the satellite to mankind will for a long time be highly [...]

Published
2018

40. Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity

Author

Fowler, Benjamin J., Gelfand, Bradley D., Kim, Younghee, Kerur, Nagaraj, Tarallo, Valeria, Hirano, Yoshio, Amarnath, Shoba, Fowler, Daniel H., Radwan, Marta, Young, Mark T., Pittman, Keir, Kubes, Paul, Agarwal, Hitesh K., Parang, Keykavous, Hinton, David R., Bastos-Carvalho, Ana, Li, Shengjian, Yasuma, Tetsuhiro, Mizutani, Takeshi, Yasuma, Reo, Wright, Charles, and Ambati, Jayakrishna

Published
2014

44. Donor-derived CD19-targeted T cells cause regression of malignancy persisting after allogeneic hematopoietic stem cell transplantation

Author

Kochenderfer, James N., Dudley, Mark E., Carpenter, Robert O., Kassim, Sadik H., Rose, Jeremy J., Telford, William G., Hakim, Frances T., Halverson, David C., Fowler, Daniel H., Hardy, Nancy M., Mato, Anthony R., Hickstein, Dennis D., Gea-Banacloche, Juan C., Pavletic, Steven Z., Sportes, Claude, Maric, Irina, Feldman, Steven A., Hansen, Brenna G., Wilder, Jennifer S., Blacklock-Schuver, Bazetta, Jena, Bipulendu, Bishop, Michael R., Gress, Ronald E., and Rosenberg, Steven A.

Published
2013
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48. Phase 2 clinical trial of rapamycin-resistant donor CD4+ Th2/Th1 (T-Rapa) cells after low-intensity allogeneic hematopoietic cell transplantation

Author

Fowler, Daniel H., Mossoba, Miriam E., Steinberg, Seth M., Halverson, David C., Stroncek, David, Khuu, Hahn M., Hakim, Frances T., Castiello, Luciano, Sabatino, Marianna, Leitman, Susan F., Mariotti, Jacopo, Gea-Banacloche, Juan C., Sportes, Claude, Hardy, Nancy M., Hickstein, Dennis D., Pavletic, Steven Z., Rowley, Scott, Goy, Andre, Donato, Michele, Korngold, Robert, Pecora, Andrew, Levine, Bruce L., June, Carl H., Gress, Ronald E., and Bishop, Michael R.

Published
2013
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49. National Institutes of Health Chronic Graft-versus-Host Disease Staging in Severely Affected Patients: Organ and Global Scoring Correlate with Established Indicators of Disease Severity and Prognosis

Author

Baird, Kristin, Steinberg, Seth M., Grkovic, Lana, Pulanic, Drazen, Cowen, Edward W., Mitchell, Sandra A., Williams, Kirsten M., Datiles, Manuel B., Bishop, Rachel, Bassim, Carol W., Mays, Jacqueline W., Edwards, Dean, Cole, Kristen, Avila, Daniele N., Taylor, Tiffany, Urban, Amanda, Joe, Galen O., Comis, Leora E., Berger, Ann, Stratton, Pamela, Zhang, Dan, Shelhamer, James H., Gea-Banacloche, Juan C., Sportes, Claude, Fowler, Daniel H., Gress, Ronald E., and Pavletic, Steven Z.

Published
2013
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