Search

Your search keyword '"Foweraker J"' showing total 153 results
Start Over Author "Foweraker J"
153 results on '"Foweraker J"'

16. Pseudomonas aeruginosa adaptation and diversification in the non-cystic fibrosis bronchiectasis lung

Author

Hilliam, Y., Moore, M. P., Iain Lamont, Bilton, D., Haworth, C. S., Foweraker, J., Walshaw, M. J., Williams, D., Fothergill, J. L., Soyza, A., Winstanley, C., and National Institute for Health Research

Subjects
Cystic Fibrosis, Virulence Factors, Respiratory System, DIVERSITY, SEQUENCE, INFECTION, Humans, PATHOGEN, Pseudomonas Infections, POPULATION, 11 Medical and Health Sciences, Cross Infection, Science & Technology, Whole Genome Sequencing, STRAINS, BIOFILM FORMATION, Sputum, Original Articles, Bronchiectasis and Respiratory Infections, United Kingdom, DI-GMP PHOSPHODIESTERASE, Bronchiectasis, Phenotype, Biofilms, Pseudomonas aeruginosa, SECRETION, Life Sciences & Biomedicine, RESISTANCE
Abstract

To characterise Pseudomonas aeruginosa populations during chronic lung infections of non-cystic fibrosis bronchiectasis patients, we used whole-genome sequencing to 1) assess the diversity of P. aeruginosa and the prevalence of multilineage infections; 2) seek evidence for cross-infection or common source acquisition; and 3) characterise P. aeruginosa adaptations. 189 isolates, obtained from the sputa of 91 patients attending 16 adult bronchiectasis centres in the UK, were whole-genome sequenced. Bronchiectasis isolates were representative of the wider P. aeruginosa population. Of 24 patients from whom multiple isolates were examined, there were seven examples of multilineage infections, probably arising from multiple infection events. The number of nucleotide variants between genomes of isolates from different patients was in some cases similar to the variations observed between isolates from individual patients, implying the possible occurrence of cross-infection or common source acquisition. Our data indicate that during infections of bronchiectasis patients, P. aeruginosa populations adapt by accumulating loss-of-function mutations, leading to changes in phenotypes including different modes of iron acquisition and variations in biofilm-associated polysaccharides. The within-population diversification suggests that larger scale longitudinal surveillance studies will be required to capture cross-infection or common source acquisition events at an early stage., P. aeruginosa co-infections occur in bronchiectasis; bacterial populations both adapt and diversify by mutation http://ow.ly/fMhj308zUv0

Published
2017

31. Models of the state

Author

Clarke, P. B., Foweraker, J., Jessop, R.D., Clarke, P. B., Foweraker, J., and Jessop, R.D.

Published
2001

32. Market forces

Author

Clarke, P. B., Foweraker, J., Jessop, R.D., Clarke, P. B., Foweraker, J., and Jessop, R.D.

Published
2001

50. Mobilization: Editor's note

Author

Alimi, E., Almeida, P., Andrews, A., Aminzade, R., Anker, J., Anner, M., Armbruster-Sandoval, M., Ayres, J., Bagguley, P., Banazak, L., Bandy, J., Barakso, M., Barkan, S., Bickham-Mendez, J., Beasley, M., Benford, R., Benski, T., Berbier, M., Beriet, C., Bernstein, M., Best, J., Beyerlien, K., Biggs, M., Binder, A., Blee, K., Borland, E., Boudreau, V., Broadbent, J., Brulle, B., Buckser, A., Burstein, P., Cable, S., Campbell, K., Carmin, J., Chabot, S., Clawson, M. A., Clemens, L., Cleveland, J., Cossu, A., Crow, B., Dalton, R., Davenport, C., Desai, M., Dimaggio, P., Doherty, B., Jennifer Earl, Eder, K., Einwohner, R., Eliasoph, N., Fallon, K., Ferree, M. M., Filiieule, O., Findlay, R., Fine, G., Fischler, L., Foweraker, J., Francisco, R., Gamson, B., Giugni, M., Gongaware, T., Goodwin, J., Gould, D., Haines, H., Hanagan, M., Haunss, S., Hewitt, L., Hicks, B., Himmelstein, J., Hochstetler, K., Holzner, C., Hourigan, N., Hug, S., Hunt, S., Imig, D., Jamison, A., Jenkins, C., Jenness, V., Jiminez, M., Johnson, E., Johnson, V., Kane, A., Keating, M., Kim, Q. -Y, Kitts, J., Klandermans, B., Kleidman, R., Kolb, F., Koopmans, R., Krinsky, J., Kubal, T., Kurtz, S., Kurzman, C., Mccarthy, J., Mcdonald, L., Mcphail, C., Meyer, D., Minkoff, D., Morris, A., and Johnston, H.

Catalog

Books, media, physical & digital resources
See catalog results