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13. Drug exposure and perceived adverse drug events reported by liver-transplant patients

Author

Nassim Kamar, Espinasse G, Hurault C, Fourtanier G, Montastruc Jl, Bagheri H, Lionel Rostaing, and Bertrand Suc

Subjects
Adult, Male, Drug, Cholagogues and Choleretics, medicine.medical_specialty, Adolescent, medicine.medical_treatment, media_common.quotation_subject, Context (language use), Liver transplantation, Tacrolimus, Quality of life, Surveys and Questionnaires, Internal medicine, medicine, Adverse Drug Reaction Reporting Systems, Humans, Pharmacology (medical), Child, Diuretics, Antihypertensive Agents, hirsutism, Aged, Retrospective Studies, media_common, Sirolimus, Pharmacology, business.industry, Proton Pump Inhibitors, Retrospective cohort study, Middle Aged, medicine.disease, Liver Transplantation, Surgery, Cyclosporine, Female, Hydroxymethylglutaryl-CoA Reductase Inhibitors, business, Immunosuppressive Agents, medicine.drug
Abstract

Posttransplant patient outcome and quality of life are affected by different factors, such as post-graft context, psychological state, and polymedication. Many surveys have been carried out to study immunosuppressant ADRs, and have mainly used a questionnaire completed by patients, but few have asked patients about their drug exposure. The aim of this study is to describe drug exposure and adverse drug events (ADEs) reported by liver-transplant patients (LTP).This observational, retrospective study assessed questionnaires from LTPs concerning demographic data, drug exposure, and ADEs.118 LTPs exposed to 5.9 (+/- 2.8) drugs with immunosuppressive regimens, consisting mainly of tacrolimus (79.3%), cyclosporine (18.1%), or sirolimus (2.6%), were also exposed to antihypertensive drugs (43.2%), protonpump inhibitors (30.5%), statins (28.8%), drugs acting on bile composition (26.3%), and diuretics (19.5%). 1,389 ADEs were reported: 30.1% neurological, 13.4% cutaneous, 12.4% hematological, 11.1% digestive, 10.1% osteomuscular, 6.6% cardiovascular, and 16.3% others. Significantly more ADEs were reported by patients exposed to cyclosporine than those receiving tacrolimus (p0.05). Patients with a transplant for18 months had more tremors and those with a transplant for79 months reported more hirsutism, gingival hypertrophia, and arterial hypertension.This study shows the value of patient-reporting via structured interviews for both drug exposure and ADEs, and the importance of this approach to complement total data collection.

Published
2009

14. Étude prospective multicentrique comparative entre la sleeve gastrectomie et le bypass gastrique chez le patient obèse à risque pendant 3 ans (PHRC SLEEVE K060213/IDRCB2007-A00373-50)

Author

Catheline, J.M., primary, Fisekidis, M., additional, Scotté, M., additional, Huten, N., additional, Chouillard, E., additional, Gugenheim, J., additional, Fourtanier, G., additional, Msika, S., additional, Fabre, J.M., additional, Sodji, M., additional, Bendacha, Y., additional, Cohen, R., additional, and Vicaut, E., additional

Published
2017
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15. Étude comparative prospective (complications et efficacité sur la perte de poids) entre la gastrectomie longitudinale et le bypass gastrique chez le patient obèse à risque pendant 3 ans (PHRC SLEEVE K060213/IDRCB2007-A00373-50 ; ClinicalTrials.gov : NTC00722995)

Author

Catheline, J.M., primary, Fysekidis, M., additional, Bendacha, Y., additional, Bdeoui, N., additional, Raghavan, V., additional, Gerard, S., additional, Portal, J.J., additional, Dbouk, R., additional, Fabre, J.M., additional, Fourtanier, G., additional, Gugenheim, J., additional, Arapis, K., additional, Huten, N., additional, Sodji, M., additional, Msika, S., additional, Scotte, M., additional, Chouillard, E., additional, Vicaut, E., additional, and Cohen, R., additional

Published
2017
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17. Étude prospective, multicentrique, comparative entre la sleevegastrectomie et le bypassgastrique en Y, 277 patients, 3 ans de suivi

Author

Catheline, J.-M., Fysekidis, M., Bendacha, Y., Portal, J.-J., Huten, N., Chouillard, E., Gugenheim, J., Fourtanier, G., Arapis, K., Msika, S., Fabre, J.M., Sodji, M., Vicaut, E., Dbouk, R., Roussel, J., and Cohen, R.

Abstract

La sleevegastrectomie laparoscopique (SGL) et le bypassgastrique en Y laparoscopique (BPGYL) sont couramment effectués, mais peu d’études ont montré la supériorité d’une stratégie par rapport à l’autre.

Published
2019
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18. Étude comparative randomisée (complications, efficacité, qualité de vie) entre la gastrectomie longitudinale et le bypass gastrique chez le patient obèse à risque pendant 3ans (PHRC SLEEVE K060213/IDRCB2007-A00373-50)

Author

Catheline, J.M., primary, Bendacha, Y., additional, Bdeoui, N., additional, Dbouk, R., additional, Raghavan, V., additional, Gérard, S., additional, Portal, J.J., additional, Fabre, J.M., additional, Fourtanier, G., additional, Gugenheim, J., additional, Huten, N., additional, Maxime, S., additional, Msika, S., additional, Scotté, M., additional, Vicaut, E., additional, and Cohen, R., additional

Published
2016
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19. Etiologie, classification et traitement des fistules traumatiques uro-génitales et génito-digestives basses dans l’est de la RDC.

Author

Rozenberg, Serge, Cadière, Guy-Bernard, Devière, Jacques, Simon, Philippe, Levêque, Alain, Van Velthoven, Roland, Fourtanier, G., Boulvain, Michel, Mukwege Mukengere, Denis, Rozenberg, Serge, Cadière, Guy-Bernard, Devière, Jacques, Simon, Philippe, Levêque, Alain, Van Velthoven, Roland, Fourtanier, G., Boulvain, Michel, and Mukwege Mukengere, Denis

Abstract

ETIOLOGIE, CLASSIFICATION ET TRAITEMENT DES FISTULES TRAUMATIQUES GÉNITO-URINAIRES ET GÉNITO-DIGESTIVES BASSES (FTUG-DB) DANS L’EST DU CONGO. Objectif généralContribution à l’amélioration de la prise en charge de la FTUG-DB en RDC en :1) Clarifiant les étiologies des FTUG-DB en RDC.2) proposant une meilleure classification de la FTUG-DB afin de définir une stratégie opératoire adaptée.3) Évaluant les traitements de la FTUG-DB à l’hôpital Panzi.Objectifs spécifiques1. L’importance des fistules iatrogènes en RDC nous a amenés à étudier l’incidence et les caractéristiques des fistules d’origine iatrogènes (2 articles).- Cesarean delivery-related fistulae in the Democratic Republic of Congo. Onsrud M1, Sjøveian S, Mukwege D. International Journal of Gynecology and Obstetrics. 2011; 114(1):10-14- Complete destruction of urethra and bladder neck following symphysiotomy and results of attempted corrective surgery. Onsrud M1, Sjøveian S, Mukwege D. Acta Obstetricia et Gynecologica. 2008; 87(5):574-5762. Suite à la découverte de cette nouvelle étiologie qu’est la fistule traumatique due au viol avec extrême violence, nous avons voulu la définir, en comprendre les raisons afin de prévenir leur survenue et déterminer la morbidité résultante de la fistule traumatique après viol (4 articles).- Sexual violence-related fistulas in the Democratic Republic of Congo. Onsrud M1, Sjøveian S, Luhiriri R, Mukwege D. Int J Gynaecol Obstet. 2008 Dec; 103(3):265-9. - Rape as a strategy of war in the Democratic Republic of the Congo. Mukwege DM1, Mohamed-Ahmed O, Fitchett JR. Int Health. 2010 Sep; 2(3):163-4.- Rape with Extreme Violence: The New Pathology in South Kivu, Democratic Republic of Congo. Denis Mukengere Mukwege, Cathy Nangini. International Journal and Obstetrics 2009; 6(12)- No more! Organized rape in the Democratic Republic of the Congo must stop now. Mukwege D. International journal of gynecology and Obstetrics 2011; 114(1):1-33. Les classifications des fistules vésico-vaginal, Doctorat en Sciences médicales (Santé Publique), info:eu-repo/semantics/nonPublished

Published
2015

27. P.124 Quels malades doit-on transplanter après résection pour CHC sur cirrhose ? Etude des facteurs pronostiques de survie sans récidive (SSR) de 2 cohortes de malades réséqués et transplantés

Author

Muscari, F., primary, Foppa, B., additional, Trocard, P., additional, Kamar, N., additional, Guinard, J.P., additional, Carrère, N., additional, Peron, J.M., additional, Fourtanier, G., additional, Pradère, B., additional, and Suc, B., additional

Published
2009
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32. Anatomie laparoscopique virtuelle de la jonction oesogastrique

Author

Cadière, Guy-Bernard, Fourtanier, G., Himpens, Jacques, Rooze, Marcel, Germay, Olivier, Martin, Claude, Cadière, Guy-Bernard, Fourtanier, G., Himpens, Jacques, Rooze, Marcel, Germay, Olivier, and Martin, Claude

Abstract

The anatomy of the GE junction is represented by computer synthetised pictures. This method allows to represent different organs from different angles, emphasis being put on the laparoscopic angle of vision. This should improve anatomical comprehension. The synthetic pictures have been constructed in a figurative representation. Fatty tissues have been omitted whereas the peritoneal layers covering organs and defining spaces are enhanced., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
1999

33. Chirurgie laparoscopique

Author

Champault, G., primary, Descottes, B., additional, Dulucq, J.L., additional, Fabre, J.M., additional, Fourtanier, G., additional, Gayet, B., additional, Johanet, H., additional, and Samama, G., additional

Published
2006
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43. Splénectomies laparoscopiques. Étude SFCL

Author

Delaitre, B., primary, Blezel, E., additional, Mantion, G., additional, Champault, G., additional, Kraimps, J.L., additional, Gainant, A., additional, Sezeur, A., additional, Bollenger, D., additional, Grapin, C., additional, Fourtanier, G., additional, and Samama, G., additional

Published
1998
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45. Unresected hepatic metastases (HM) from colorectal cancer (CRC). Prospective prognostic factor analysis on 544 cases from fondation Française de cancerologie digestive (FFCD)

Author

Rougier, Ph., primary, Milan, Ch., additional, Bedenne, L., additional, Lazorthes, F., additional, Fourtanier, G., additional, Partensky, C., additional, Conroy, Th., additional, Parneix, M., additional, Gouzi, J.L., additional, Gignoux, M., additional, Boissel, P., additional, Bourry, J., additional, Ben Bouali, A.K., additional, Ducreux, M., additional, Baumel, H., additional, and Faivre, J., additional

Published
1993
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46. Aorto-Enteric Fistulas.

Author

Glock, Y., Fourtanier, G., and Puel, P.

Abstract

The authors report a series of 10 patients who presented with 4 primary aorto-enteric fistulas (AEFs) and 8 secondary AEFs. Gastrointestinal bleeding is the main feature of this serious complication. The diagnosis is difficult; no single procedure: endoscopy, angiography, CAT scan, or upper gastrointestinal film series is regularly diagnostic for AEF. Acute massive exsanguination needs urgent explorative xyphopubic midline laparotomy without preoperative work- up. The surgical treatment consists of endoaneurysmorraphy or graft prosthesis resection without "in situ" vascular reconstruction. The extraanatomic bypass permits the revascularization of the lower limbs. In this series, the prognosis appeared to be poor. The mortality rate with primary AEF was 50%, and the morbidity consisted, after "in situ" reconstruction, of early or late secondary AEF. In secondary AEF, the mortality rate after extraanatomic reconstruction with graft excision was 62%. The main complications were infection, fistuliza tion, and hemorrhage. [ABSTRACT FROM PUBLISHER]

Published
1987
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47. Anatomie laparoscopique virtuelle de la jonction œsogastrique

Author

Cadière, G.B., Fourtanier, G, Himpens, J, Rooze, M, Germay, O, and Martin, C

Abstract

The anatomy of the GE junction is represented by computer synthetised pictures. This method allows to represent different organs from different angles, emphasis being put on the laparoscopic angle of vision. This should improve anatomical comprehension. The synthetic pictures have been constructed in a figurative representation. Fatty tissues have been omitted whereas the peritoneal layers covering organs and defining spaces are enhanced.

Published
1998
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48. Leucoencephalopathy after cyclosporine in a liver transplant

Author

Lloveras, J.‐J., Larrue, V., Suc, E., Fourtanier, G., and Durand, D.

Abstract

Numerous reports have emphasized neurologic manifestations after cyclosporine therapy. Among them, leucoencephalopathy appears as rarely documented. We describe such a case in a liver transplant recipient who presented serious central nervous system complications; clinical feature was essentially confusion and drowsiness. A close relationship existed between neurological signs and administration of cyclosporine during the post‐operative period. A sequential study of computed tomographic (CT) scanning and magnetic resonance (MR) imaging of the head showed partially regressive white matter abnormalities. On one occasion, cyclosporine level was measured in cerebrospinal fluid (CSF) showing a CSF/blood ratio close to 0.5. This case stresses the importance of CT scanning and MR imaging when cyclosporine is incriminated as the cause of neurologic symptoms in transplant patients. Moreover, presence of cyclosporine in CSF suggests the possibility of increasing permeability of the blood brain barrier (BBB) in liver transplants.

Published
1990
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