89 results on '"Foti N"'
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2. Stability of the World Trade Web over Time - An Extinction Analysis
- Author
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Foti, N., Pauls, S., and Rockmore, Daniel N.
- Subjects
Quantitative Finance - General Finance ,Physics - Physics and Society - Abstract
The World Trade Web (WTW) is a weighted network whose nodes correspond to countries with edge weights reflecting the value of imports and/or exports between countries. In this paper we introduce to this macroeconomic system the notion of extinction analysis, a technique often used in the analysis of ecosystems, for the purposes of investigating the robustness of this network. In particular, we subject the WTW to a principled set of in silico "knockout experiments," akin to those carried out in the investigation of food webs, but suitably adapted to this macroeconomic network. Broadly, our experiments show that over time the WTW moves to a "robust yet fragile" configuration where it is robust to random failures but fragile under targeted attack. This change in stability is highly correlated with the connectance (edge density) of the network. Moreover, there is evidence of a sharp change in the structure of the network in the 1960s and 1970s, where most measures of robustness rapidly increase before resuming a declining trend. We interpret these results in the context in the post-World War II move towards globalization. Globalization coincides with the sharp increase in robustness but also with a rise in those measures (e.g., connectance and trade imbalances) which correlate with decreases in robustness. The peak of robustness is reached after the onset of globalization policy but before the negative impacts are substantial. These analyses depend on a simple model of dynamics that rebalances the trade flow upon network perturbation, the most dramatic of which is node deletion. More subtle and textured forms of perturbation lead to the definition of other measures of node importance as well as vulnerability. We anticipate that experiments and measures like these can play an important role in the evaluation of the stability of economic systems., Comment: 20 pages, 6 Figures, 3 Tables
- Published
- 2011
3. Appendectomy during the COVID-19 pandemic in Italy: a multicenter ambispective cohort study by the Italian Society of Endoscopic Surgery and new technologies (the CRAC study)
- Author
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Sartori, A, Podda, M, Botteri, E, Passera, R, Agresta, F, Arezzo, A, Guerrieri, M, Ortenzi, M, Cavallo, F, Zese, M, Prando, D, Restini, E, Cianci, P, Millo, P, Brachet Contul, R, Serrao, A, Abatini, F, Altomare, D, Picciariello, A, Chetta, G, Lattanzio, F, Tonini, V, Gori, A, Jovine, E, Mastrangelo, L, Sartarelli, L, Frena, A, Malpaga, A, Bertelli, F, Pignata, G, Andreuccetti, J, Sanna, S, Lares, B, Sechi, R, Cillara, N, Pisanu, A, Delogu, D, Ciaccio, G, Farulla, M, Casati, M, Laface, L, De Luca, M, Russello, D, Latteri, S, Longoni, M, Masci, E, Vigna, S, Campanile, F, Foti, N, Lepiane, P, Balla, A, Cantore, F, Raveglia, V, Borghi, F, Giraudo, G, Verzelli, A, Budassi, A, Patriti, A, Foghetti, D, Montin, U, Amadio, L, Anania, G, Bombardini, C, Fabbri, N, Feo, C, Cianchi, F, Manetti, A, Lucchese, M, Soricelli, E, Ceccarelli, G, Patiti, M, Frascio, M, Stabilini, C, Filauro, M, Barberis, A, Troian, M, Nagliati, C, Campagnacci, R, Maurizi, A, Berti, S, Gennai, A, Marvaso, A, D'Antonio, D, Mazzola, L, Selvaggi, F, Carini, S, Costanzo, F, Boccia, L, Pascariello, A, Perrotta, N, Celiento, M, Opocher, E, Giovenzana, M, Stella, M, Ferrara, F, Boni, L, Abate, E, Da Lio, C, Valli, V, Gelmini, R, Serra, F, Piccoli, M, Gozzo, D, Gattolin, A, Sasia, D, Balani, A, Petronio, B, Calo, P, Canu, G, Contarini, E, Piatto, G, Vettoretto, N, Caprioli, M, Braga, M, Chiappetta, M, Maida, P, Tammaro, P, De Palma, G, Milone, M, Bottino, V, Canfora, A, Bagaglini, G, Agrusa, A, Barone, M, Mirabella, A, Marino, M, Gulotta, G, Romano, G, Sorrentino, M, Ferfoglia, S, Papagni, V, Eramo, S, Boselli, C, Basti, M, Caracino, V, Moretto, G, Inama, M, Capelli, P, Conti, L, Muratore, A, Cuoghi, M, Zerbinati, A, Corso, S, Vasino, M, Montuori, M, Fidanza, F, Lucchetta, A, Giuliani, A, Dinatale, G, Zanzi, F, Guariniello, A, Bonilauri, S, Frazzetta, G, Garino, M, Marafante, C, Gioffre, A, Del Monte, S, Sganga, G, Fransvea, P, Grande, M, Siragusa, L, Sica, G, Paola, M, Passantino, D, Catani, M, Ricci, F, Lauro, E, Facci, E, Parini, D, Armellino, M, Argenio, G, Porcu, A, Perra, T, Bordoni, P, Fleres, F, Parisi, A, Rossi, S, Saracco, R, Bono, D, Viora, T, Orlando, F, Ferrero, A, Fontana, A, De Paolis, P, Visconti, D, Quaglino, F, Festa, F, Palagi, S, Lo Secco, G, Morino, M, Allaix, M, Salzano, A, Tirone, G, Motter, M, Zanus, G, Passuello, N, Massani, M, Tutino, R, Manzini, N, Terranova, S, Merenda, R, Nordio, S, Zonta, S, Lovisetto, F, Guglielmi, A, Campagnaro, T, Amedeo, E, Scollica, M, Amodio, P, Giannotti, D, Olmi, S, Oldani, A, Sartori A., Podda M., Botteri E., Passera R., Agresta F., Arezzo A., Guerrieri M., Ortenzi M., Cavallo F., Zese M., Prando D., Restini E., Cianci P., Millo P., Brachet Contul R., Serrao A., Abatini F., Altomare D. F., Picciariello A., Chetta G., Lattanzio F., Tonini V., Gori A., Jovine E., Mastrangelo L., Sartarelli L., Frena A., Malpaga A., Bertelli F., Pignata G., Andreuccetti J., Sanna S., Lares B., Sechi R., Cillara N., Pisanu A., Delogu D., Ciaccio G., Farulla M., Casati M., Laface L., De Luca M., Russello D., Latteri S., Longoni M., Masci E., Vigna S., Campanile F. C., Foti N., Lepiane P., Balla A., Cantore F., Raveglia V., Borghi F., Giraudo G., Verzelli A., Budassi A., Patriti A., Foghetti D., Montin U., Amadio L., Anania G., Bombardini C., Fabbri N., Feo C., Cianchi F., Manetti A., Lucchese M., Soricelli E., Ceccarelli G., Patiti M., Frascio M., Stabilini C., Filauro M., Barberis A., Troian M., Nagliati C., Campagnacci R., Maurizi A., Berti S., Gennai A., Marvaso A., D'Antonio D., Feo C. V., Mazzola L., Selvaggi F., Carini S., Costanzo F., Boccia L., Pascariello A., Perrotta N., Celiento M., Opocher E., Giovenzana M., Stella M., Ferrara F., Boni L., Abate E., Da Lio C., Valli V., Gelmini R., Serra F., Piccoli M., Gozzo D., Gattolin A., Sasia D., Balani A., Petronio B., Calo P. G., Canu G. L., Contarini E., Piatto G., Vettoretto N., Caprioli M., Braga M., Chiappetta M. F., Maida P., Tammaro P., De Palma G., Milone M., Bottino V., Canfora A., Bagaglini G., Agrusa A., Barone M., Mirabella A., Marino M. V., Gulotta G., Romano G., Sorrentino M., Ferfoglia S., Papagni V., Eramo S., Boselli C., Basti M., Caracino V., Moretto G., Inama M., Capelli P., Conti L., Muratore A., Cuoghi M. M., Zerbinati A., Corso S., Vasino M. C., Montuori M., Fidanza F., Lucchetta A., Giuliani A., Dinatale G., Zanzi F., Guariniello A., Bonilauri S., Frazzetta G., Garino M., Marafante C., Gioffre A., Del Monte S. R., Sganga G., Fransvea P., Grande M., Siragusa L., Sica G., Paola M., Passantino D. G., Catani M., Ricci F., Lauro E., Facci E., Parini D., Armellino M. F., Argenio G., Porcu A., Perra T., Bordoni P., Fleres F., Parisi A., Rossi S., Saracco R., Bono D., Viora T., Orlando F., Ferrero A., Fontana A. P., De Paolis P., Visconti D., Quaglino F., Festa F., Palagi S., Lo Secco G., Morino M., Allaix M. E., Salzano A., Tirone G., Motter M., Zanus G., Passuello N., Massani M., Tutino R., Manzini N., Terranova S., Merenda R., Nordio S., Zonta S., Lovisetto F., Guglielmi A., Campagnaro T., Amedeo E., Scollica M., Amodio P., Giannotti D., Olmi S., Oldani A., Sartori, A, Podda, M, Botteri, E, Passera, R, Agresta, F, Arezzo, A, Guerrieri, M, Ortenzi, M, Cavallo, F, Zese, M, Prando, D, Restini, E, Cianci, P, Millo, P, Brachet Contul, R, Serrao, A, Abatini, F, Altomare, D, Picciariello, A, Chetta, G, Lattanzio, F, Tonini, V, Gori, A, Jovine, E, Mastrangelo, L, Sartarelli, L, Frena, A, Malpaga, A, Bertelli, F, Pignata, G, Andreuccetti, J, Sanna, S, Lares, B, Sechi, R, Cillara, N, Pisanu, A, Delogu, D, Ciaccio, G, Farulla, M, Casati, M, Laface, L, De Luca, M, Russello, D, Latteri, S, Longoni, M, Masci, E, Vigna, S, Campanile, F, Foti, N, Lepiane, P, Balla, A, Cantore, F, Raveglia, V, Borghi, F, Giraudo, G, Verzelli, A, Budassi, A, Patriti, A, Foghetti, D, Montin, U, Amadio, L, Anania, G, Bombardini, C, Fabbri, N, Feo, C, Cianchi, F, Manetti, A, Lucchese, M, Soricelli, E, Ceccarelli, G, Patiti, M, Frascio, M, Stabilini, C, Filauro, M, Barberis, A, Troian, M, Nagliati, C, Campagnacci, R, Maurizi, A, Berti, S, Gennai, A, Marvaso, A, D'Antonio, D, Mazzola, L, Selvaggi, F, Carini, S, Costanzo, F, Boccia, L, Pascariello, A, Perrotta, N, Celiento, M, Opocher, E, Giovenzana, M, Stella, M, Ferrara, F, Boni, L, Abate, E, Da Lio, C, Valli, V, Gelmini, R, Serra, F, Piccoli, M, Gozzo, D, Gattolin, A, Sasia, D, Balani, A, Petronio, B, Calo, P, Canu, G, Contarini, E, Piatto, G, Vettoretto, N, Caprioli, M, Braga, M, Chiappetta, M, Maida, P, Tammaro, P, De Palma, G, Milone, M, Bottino, V, Canfora, A, Bagaglini, G, Agrusa, A, Barone, M, Mirabella, A, Marino, M, Gulotta, G, Romano, G, Sorrentino, M, Ferfoglia, S, Papagni, V, Eramo, S, Boselli, C, Basti, M, Caracino, V, Moretto, G, Inama, M, Capelli, P, Conti, L, Muratore, A, Cuoghi, M, Zerbinati, A, Corso, S, Vasino, M, Montuori, M, Fidanza, F, Lucchetta, A, Giuliani, A, Dinatale, G, Zanzi, F, Guariniello, A, Bonilauri, S, Frazzetta, G, Garino, M, Marafante, C, Gioffre, A, Del Monte, S, Sganga, G, Fransvea, P, Grande, M, Siragusa, L, Sica, G, Paola, M, Passantino, D, Catani, M, Ricci, F, Lauro, E, Facci, E, Parini, D, Armellino, M, Argenio, G, Porcu, A, Perra, T, Bordoni, P, Fleres, F, Parisi, A, Rossi, S, Saracco, R, Bono, D, Viora, T, Orlando, F, Ferrero, A, Fontana, A, De Paolis, P, Visconti, D, Quaglino, F, Festa, F, Palagi, S, Lo Secco, G, Morino, M, Allaix, M, Salzano, A, Tirone, G, Motter, M, Zanus, G, Passuello, N, Massani, M, Tutino, R, Manzini, N, Terranova, S, Merenda, R, Nordio, S, Zonta, S, Lovisetto, F, Guglielmi, A, Campagnaro, T, Amedeo, E, Scollica, M, Amodio, P, Giannotti, D, Olmi, S, Oldani, A, Sartori A., Podda M., Botteri E., Passera R., Agresta F., Arezzo A., Guerrieri M., Ortenzi M., Cavallo F., Zese M., Prando D., Restini E., Cianci P., Millo P., Brachet Contul R., Serrao A., Abatini F., Altomare D. F., Picciariello A., Chetta G., Lattanzio F., Tonini V., Gori A., Jovine E., Mastrangelo L., Sartarelli L., Frena A., Malpaga A., Bertelli F., Pignata G., Andreuccetti J., Sanna S., Lares B., Sechi R., Cillara N., Pisanu A., Delogu D., Ciaccio G., Farulla M., Casati M., Laface L., De Luca M., Russello D., Latteri S., Longoni M., Masci E., Vigna S., Campanile F. C., Foti N., Lepiane P., Balla A., Cantore F., Raveglia V., Borghi F., Giraudo G., Verzelli A., Budassi A., Patriti A., Foghetti D., Montin U., Amadio L., Anania G., Bombardini C., Fabbri N., Feo C., Cianchi F., Manetti A., Lucchese M., Soricelli E., Ceccarelli G., Patiti M., Frascio M., Stabilini C., Filauro M., Barberis A., Troian M., Nagliati C., Campagnacci R., Maurizi A., Berti S., Gennai A., Marvaso A., D'Antonio D., Feo C. V., Mazzola L., Selvaggi F., Carini S., Costanzo F., Boccia L., Pascariello A., Perrotta N., Celiento M., Opocher E., Giovenzana M., Stella M., Ferrara F., Boni L., Abate E., Da Lio C., Valli V., Gelmini R., Serra F., Piccoli M., Gozzo D., Gattolin A., Sasia D., Balani A., Petronio B., Calo P. G., Canu G. L., Contarini E., Piatto G., Vettoretto N., Caprioli M., Braga M., Chiappetta M. F., Maida P., Tammaro P., De Palma G., Milone M., Bottino V., Canfora A., Bagaglini G., Agrusa A., Barone M., Mirabella A., Marino M. V., Gulotta G., Romano G., Sorrentino M., Ferfoglia S., Papagni V., Eramo S., Boselli C., Basti M., Caracino V., Moretto G., Inama M., Capelli P., Conti L., Muratore A., Cuoghi M. M., Zerbinati A., Corso S., Vasino M. C., Montuori M., Fidanza F., Lucchetta A., Giuliani A., Dinatale G., Zanzi F., Guariniello A., Bonilauri S., Frazzetta G., Garino M., Marafante C., Gioffre A., Del Monte S. R., Sganga G., Fransvea P., Grande M., Siragusa L., Sica G., Paola M., Passantino D. G., Catani M., Ricci F., Lauro E., Facci E., Parini D., Armellino M. F., Argenio G., Porcu A., Perra T., Bordoni P., Fleres F., Parisi A., Rossi S., Saracco R., Bono D., Viora T., Orlando F., Ferrero A., Fontana A. P., De Paolis P., Visconti D., Quaglino F., Festa F., Palagi S., Lo Secco G., Morino M., Allaix M. E., Salzano A., Tirone G., Motter M., Zanus G., Passuello N., Massani M., Tutino R., Manzini N., Terranova S., Merenda R., Nordio S., Zonta S., Lovisetto F., Guglielmi A., Campagnaro T., Amedeo E., Scollica M., Amodio P., Giannotti D., Olmi S., and Oldani A.
- Abstract
Major surgical societies advised using non-operative management of appendicitis and suggested against laparoscopy during the COVID-19 pandemic. The hypothesis is that a significant reduction in the number of emergent appendectomies was observed during the pandemic, restricted to complex cases. The study aimed to analyse emergent surgical appendectomies during pandemic on a national basis and compare it to the same period of the previous year. This is a multicentre, retrospective, observational study investigating the outcomes of patients undergoing emergent appendectomy in March–April 2019 vs March–April 2020. The primary outcome was the number of appendectomies performed, classified according to the American Association for the Surgery of Trauma (AAST) score. Secondary outcomes were the type of surgical technique employed (laparoscopic vs open) and the complication rates. One thousand five hundred forty one patients with acute appendicitis underwent surgery during the two study periods. 1337 (86.8%) patients met the inclusion criteria: 546 (40.8%) patients underwent surgery for acute appendicitis in 2020 and 791 (59.2%) in 2019. According to AAST, patients with complicated appendicitis operated in 2019 were 30.3% vs 39.9% in 2020 (p = 0.001). We observed an increase in the number of post-operative complications in 2020 (15.9%) compared to 2019 (9.6%) (p < 0.001). The following determinants increased the likelihood of complication occurrence: undergoing surgery during 2020 (+ 67%), the increase of a unit in the AAST score (+ 26%), surgery performed > 24 h after admission (+ 58%), open surgery (+ 112%) and conversion to open surgery (+ 166%). In Italian hospitals, in March and April 2020, the number of appendectomies has drastically dropped. During the first pandemic wave, patients undergoing surgery were more frequently affected by more severe appendicitis than the previous year's timeframe and experienced a higher number of complications. Trial registrat
- Published
- 2021
4. Appendectomy during the COVID-19 pandemic in Italy: a multicenter ambispective cohort study by the Italian Society of Endoscopic Surgery and new technologies (the CRAC study)
- Author
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Sartori A., Podda M., Botteri E., Passera R., Agresta F., Arezzo A., Guerrieri M., Ortenzi M., Cavallo F., Zese M., Prando D., Restini E., Cianci P., Millo P., Brachet Contul R., Serrao A., Abatini F., Altomare D. F., Picciariello A., Chetta G., Lattanzio F., Tonini V., Gori A., Jovine E., Mastrangelo L., Sartarelli L., Frena A., Malpaga A., Bertelli F., Pignata G., Andreuccetti J., Sanna S., Lares B., Sechi R., Cillara N., Pisanu A., Delogu D., Ciaccio G., Farulla M., Casati M., Laface L., De Luca M., Russello D., Latteri S., Longoni M., Masci E., Vigna S., Campanile F. C., Foti N., Lepiane P., Balla A., Cantore F., Raveglia V., Borghi F., Giraudo G., Verzelli A., Budassi A., Patriti A., Foghetti D., Montin U., Amadio L., Anania G., Bombardini C., Fabbri N., Feo C., Cianchi F., Manetti A., Lucchese M., Soricelli E., Ceccarelli G., Patiti M., Frascio M., Stabilini C., Filauro M., Barberis A., Troian M., Nagliati C., Campagnacci R., Maurizi A., Berti S., Gennai A., Marvaso A., D'Antonio D., Feo C. V., Mazzola L., Selvaggi F., Carini S., Costanzo F., Boccia L., Pascariello A., Perrotta N., Celiento M., Opocher E., Giovenzana M., Stella M., Ferrara F., Boni L., Abate E., Da Lio C., Valli V., Gelmini R., Serra F., Piccoli M., Gozzo D., Gattolin A., Sasia D., Balani A., Petronio B., Calo P. G., Canu G. L., Contarini E., Piatto G., Vettoretto N., Caprioli M., Braga M., Chiappetta M. F., Maida P., Tammaro P., De Palma G., Milone M., Bottino V., Canfora A., Bagaglini G., Agrusa A., Barone M., Mirabella A., Marino M. V., Gulotta G., Romano G., Sorrentino M., Ferfoglia S., Papagni V., Eramo S., Boselli C., Basti M., Caracino V., Moretto G., Inama M., Capelli P., Conti L., Muratore A., Cuoghi M. M., Zerbinati A., Corso S., Vasino M. C., Montuori M., Fidanza F., Lucchetta A., Giuliani A., Dinatale G., Zanzi F., Guariniello A., Bonilauri S., Frazzetta G., Garino M., Marafante C., Gioffre A., Del Monte S. R., Sganga G., Fransvea P., Grande M., Siragusa L., Sica G., Paola M., Passantino D. G., Catani M., Ricci F., Lauro E., Facci E., Parini D., Armellino M. F., Argenio G., Porcu A., Perra T., Bordoni P., Fleres F., Parisi A., Rossi S., Saracco R., Bono D., Viora T., Orlando F., Ferrero A., Fontana A. P., De Paolis P., Visconti D., Quaglino F., Festa F., Palagi S., Lo Secco G., Morino M., Allaix M. E., Salzano A., Tirone G., Motter M., Zanus G., Passuello N., Massani M., Tutino R., Manzini N., Terranova S., Merenda R., Nordio S., Zonta S., Lovisetto F., Guglielmi A., Campagnaro T., Amedeo E., Scollica M., Amodio P., Giannotti D., Olmi S., Oldani A., Sartori, A., Podda, M., Botteri, E., Passera, R., Agresta, F., Arezzo, A., Guerrieri, M., Ortenzi, M., Cavallo, F., Zese, M., Prando, D., Restini, E., Cianci, P., Millo, P., Brachet Contul, R., Serrao, A., Abatini, F., Altomare, D. F., Picciariello, A., Chetta, G., Lattanzio, F., Tonini, V., Gori, A., Jovine, E., Mastrangelo, L., Sartarelli, L., Frena, A., Malpaga, A., Bertelli, F., Pignata, G., Andreuccetti, J., Sanna, S., Lares, B., Sechi, R., Cillara, N., Pisanu, A., Delogu, D., Ciaccio, G., Farulla, M., Casati, M., Laface, L., De Luca, M., Russello, D., Latteri, S., Longoni, M., Masci, E., Vigna, S., Campanile, F. C., Foti, N., Lepiane, P., Balla, A., Cantore, F., Raveglia, V., Borghi, F., Giraudo, G., Verzelli, A., Budassi, A., Patriti, A., Foghetti, D., Montin, U., Amadio, L., Anania, G., Bombardini, C., Fabbri, N., Feo, C., Cianchi, F., Manetti, A., Lucchese, M., Soricelli, E., Ceccarelli, G., Patiti, M., Frascio, M., Stabilini, C., Filauro, M., Barberis, A., Troian, M., Nagliati, C., Campagnacci, R., Maurizi, A., Berti, S., Gennai, A., Marvaso, A., D'Antonio, D., Feo, C. V., Mazzola, L., Selvaggi, F., Carini, S., Costanzo, F., Boccia, L., Pascariello, A., Perrotta, N., Celiento, M., Opocher, E., Giovenzana, M., Stella, M., Ferrara, F., Boni, L., Abate, E., Da Lio, C., Valli, V., Gelmini, R., Serra, F., Piccoli, M., Gozzo, D., Gattolin, A., Sasia, D., Balani, A., Petronio, B., Calo, P. G., Canu, G. L., Contarini, E., Piatto, G., Vettoretto, N., Caprioli, M., Braga, M., Chiappetta, M. F., Maida, P., Tammaro, P., De Palma, G., Milone, M., Bottino, V., Canfora, A., Bagaglini, G., Agrusa, A., Barone, M., Mirabella, A., Marino, M. V., Gulotta, G., Romano, G., Sorrentino, M., Ferfoglia, S., Papagni, V., Eramo, S., Boselli, C., Basti, M., Caracino, V., Moretto, G., Inama, M., Capelli, P., Conti, L., Muratore, A., Cuoghi, M. M., Zerbinati, A., Corso, S., Vasino, M. C., Montuori, M., Fidanza, F., Lucchetta, A., Giuliani, A., Dinatale, G., Zanzi, F., Guariniello, A., Bonilauri, S., Frazzetta, G., Garino, M., Marafante, C., Gioffre, A., Del Monte, S. R., Sganga, G., Fransvea, P., Grande, M., Siragusa, L., Sica, G., Paola, M., Passantino, D. G., Catani, M., Ricci, F., Lauro, E., Facci, E., Parini, D., Armellino, M. F., Argenio, G., Porcu, A., Perra, T., Bordoni, P., Fleres, F., Parisi, A., Rossi, S., Saracco, R., Bono, D., Viora, T., Orlando, F., Ferrero, A., Fontana, A. P., De Paolis, P., Visconti, D., Quaglino, F., Festa, F., Palagi, S., Lo Secco, G., Morino, M., Allaix, M. E., Salzano, A., Tirone, G., Motter, M., Zanus, G., Passuello, N., Massani, M., Tutino, R., Manzini, N., Terranova, S., Merenda, R., Nordio, S., Zonta, S., Lovisetto, F., Guglielmi, A., Campagnaro, T., Amedeo, E., Scollica, M., Amodio, P., Giannotti, D., Olmi, S., Oldani, A., Sartori A., Podda M., Botteri E., Passera R., Agresta F., Arezzo A., Guerrieri M., Ortenzi M., Cavallo F., Zese M., Prando D., Restini E., Cianci P., Millo P., Brachet Contul R., Serrao A., Abatini F., Altomare D.F., Picciariello A., Chetta G., Lattanzio F., Tonini V., Gori A., Jovine E., Mastrangelo L., Sartarelli L., Frena A., Malpaga A., Bertelli F., Pignata G., Andreuccetti J., Sanna S., Lares B., Sechi R., Cillara N., Pisanu A., Delogu D., Ciaccio G., Farulla M., Casati M., Laface L., De Luca M., Russello D., Latteri S., Longoni M., Masci E., Vigna S., Campanile F.C., Foti N., Lepiane P., Balla A., Cantore F., Raveglia V., Borghi F., Giraudo G., Verzelli A., Budassi A., Patriti A., Foghetti D., Montin U., Amadio L., Anania G., Bombardini C., Fabbri N., Feo C., Cianchi F., Manetti A., Lucchese M., Soricelli E., Ceccarelli G., Patiti M., Frascio M., Stabilini C., Filauro M., Barberis A., Troian M., Nagliati C., Campagnacci R., Maurizi A., Berti S., Gennai A., Marvaso A., D'Antonio D., Feo C.V., Mazzola L., Selvaggi F., Carini S., Costanzo F., Boccia L., Pascariello A., Perrotta N., Celiento M., Opocher E., Giovenzana M., Stella M., Ferrara F., Boni L., Abate E., Da Lio C., Valli V., Gelmini R., Serra F., Piccoli M., Gozzo D., Gattolin A., Sasia D., Balani A., Petronio B., Calo P.G., Canu G.L., Contarini E., Piatto G., Vettoretto N., Caprioli M., Braga M., Chiappetta M.F., Maida P., Tammaro P., De Palma G., Milone M., Bottino V., Canfora A., Bagaglini G., Agrusa A., Barone M., Mirabella A., Marino M.V., Gulotta G., Romano G., Sorrentino M., Ferfoglia S., Papagni V., Eramo S., Boselli C., Basti M., Caracino V., Moretto G., Inama M., Capelli P., Conti L., Muratore A., Cuoghi M.M., Zerbinati A., Corso S., Vasino M.C., Montuori M., Fidanza F., Lucchetta A., Giuliani A., Dinatale G., Zanzi F., Guariniello A., Bonilauri S., Frazzetta G., Garino M., Marafante C., Gioffre A., Del Monte S.R., Sganga G., Fransvea P., Grande M., Siragusa L., Sica G., Paola M., Passantino D.G., Catani M., Ricci F., Lauro E., Facci E., Parini D., Armellino M.F., Argenio G., Porcu A., Perra T., Bordoni P., Fleres F., Parisi A., Rossi S., Saracco R., Bono D., Viora T., Orlando F., Ferrero A., Fontana A.P., De Paolis P., Visconti D., Quaglino F., Festa F., Palagi S., Lo Secco G., Morino M., Allaix M.E., Salzano A., Tirone G., Motter M., Zanus G., Passuello N., Massani M., Tutino R., Manzini N., Terranova S., Merenda R., Nordio S., Zonta S., Lovisetto F., Guglielmi A., Campagnaro T., Amedeo E., Scollica M., Amodio P., Giannotti D., Olmi S., Oldani A., Sartori, Alberto, Podda, Mauro, Botteri, Emanuele, Passera, Roberto, Agresta, Ferdinando, Arezzo, Alberto, M Guerrieri, M Ortenzi, F Cavallo, M Zese, D Prando, E Restini, P Cianci, P Millo, R Brachet Contul, A Serrao, F Abatini, D F Altomare, A Picciariello, G Chetta, F Lattanzio, V Tonini, A Gori, E Jovine, L Mastrangelo, L Sartarelli, A Frena, A Malpaga, F Bertelli, G Pignata, J Andreuccetti, S Sanna, B Lares, R Sechi, N Cillara, A Pisanu, D Delogu, G Ciaccio, M Farulla, M Casati, L Laface, M De Luca, D Russello, S Latteri, M Longoni, E Masci, S Vigna, F C Campanile, N Foti, P Lepiane, A Balla, F Cantore, V Raveglia, F Borghi, G Giraudo, A Verzelli, A Budassi, A Patriti, D Foghetti, U Montin, L Amadio, G Anania, C Bombardini, Niccolò Fabbri, Carlo Feo, F Cianchi, A Manetti, M Lucchese, E Soricelli, G Ceccarelli, M Patiti, M Frascio, C Stabilini, M Filauro, A Barberis, M Troian, C Nagliati, R Campagnacci, A Maurizi, S Berti, A Gennai, A Marvaso, D D'Antonio, C V Feo, N Fabbri, L Mazzola, F Selvaggi, S Carini, F Costanzo, L Boccia, A Pascariello, N Perrotta, M Celiento, E Opocher, M Giovenzana, M Stella, F Ferrara, L Boni, E Abate, C Da Lio, V Valli, R Gelmini, F Serra, M Piccoli, D Gozzo, A Gattolin, D Sasia, A Balani, B Petronio, P G Calò, G L Canu, E Contarini, G Piatto, N Vettoretto, M Caprioli, M Braga, M F Chiappetta, P Maida, P Tammaro, G De Palma, M Milone, V Bottino, A Canfora, F Selvaggi, G Bagaglini, A Agrusa, M Barone, A Mirabella, M V Marino, G Gulotta, G Romano, M Sorrentino, S Ferfoglia, V Papagni, S Eramo, C Boselli, M Basti, V Caracino, G Moretto, M Inama, P Capelli, L Conti, A Muratore, M M Cuoghi, A Zerbinati, S Corso, M C Vasino, M Montuori, F Fidanza, A Lucchetta, A Giuliani, G Dinatale, F Zanzi, A Guariniello, S Bonilauri, G Frazzetta, M Garino, C Marafante, A Gioffrè, S R Del Monte, G Sganga, P Fransvea, M Grande, L Siragusa, G Sica, M Paola, D G Passantino, Marco Catani, F Ricci, E Lauro, E Facci, D Parini, M F Armellino, G Argenio, A Porcu, T Perra, P Bordoni, F Fleres, A Parisi, S Rossi, R Saracco, D Bono, T Viora, F Orlando, A Ferrero, A P Fontana, P De Paolis, D Visconti, F Quaglino, F Festa, S Palagi, G Lo Secco, M Morino, M E Allaix, A Salzano, G Tirone, M Motter, G Zanus, N Passuello, M Massani, R Tutino, N Manzini, S Terranova, R Merenda, S Nordio, S Zonta, F Lovisetto, A Guglielmi, T Campagnaro, E Amedeo, M Scollica, P Amodio, D Giannotti, S Olmi, A Oldani, Sartori, A, Podda, M, Botteri, E, Passera, R, Agresta, F, Arezzo, A, Guerrieri, M, Ortenzi, M, Cavallo, F, Zese, M, Prando, D, Restini, E, Cianci, P, Millo, P, Brachet Contul, R, Serrao, A, Abatini, F, Altomare, D, Picciariello, A, Chetta, G, Lattanzio, F, Tonini, V, Gori, A, Jovine, E, Mastrangelo, L, Sartarelli, L, Frena, A, Malpaga, A, Bertelli, F, Pignata, G, Andreuccetti, J, Sanna, S, Lares, B, Sechi, R, Cillara, N, Pisanu, A, Delogu, D, Ciaccio, G, Farulla, M, Casati, M, Laface, L, De Luca, M, Russello, D, Latteri, S, Longoni, M, Masci, E, Vigna, S, Campanile, F, Foti, N, Lepiane, P, Balla, A, Cantore, F, Raveglia, V, Borghi, F, Giraudo, G, Verzelli, A, Budassi, A, Patriti, A, Foghetti, D, Montin, U, Amadio, L, Anania, G, Bombardini, C, Fabbri, N, Feo, C, Cianchi, F, Manetti, A, Lucchese, M, Soricelli, E, Ceccarelli, G, Patiti, M, Frascio, M, Stabilini, C, Filauro, M, Barberis, A, Troian, M, Nagliati, C, Campagnacci, R, Maurizi, A, Berti, S, Gennai, A, Marvaso, A, D'Antonio, D, Mazzola, L, Selvaggi, F, Carini, S, Costanzo, F, Boccia, L, Pascariello, A, Perrotta, N, Celiento, M, Opocher, E, Giovenzana, M, Stella, M, Ferrara, F, Boni, L, Abate, E, Da Lio, C, Valli, V, Gelmini, R, Serra, F, Piccoli, M, Gozzo, D, Gattolin, A, Sasia, D, Balani, A, Petronio, B, Calo, P, Canu, G, Contarini, E, Piatto, G, Vettoretto, N, Caprioli, M, Braga, M, Chiappetta, M, Maida, P, Tammaro, P, De Palma, G, Milone, M, Bottino, V, Canfora, A, Bagaglini, G, Agrusa, A, Barone, M, Mirabella, A, Marino, M, Gulotta, G, Romano, G, Sorrentino, M, Ferfoglia, S, Papagni, V, Eramo, S, Boselli, C, Basti, M, Caracino, V, Moretto, G, Inama, M, Capelli, P, Conti, L, Muratore, A, Cuoghi, M, Zerbinati, A, Corso, S, Vasino, M, Montuori, M, Fidanza, F, Lucchetta, A, Giuliani, A, Dinatale, G, Zanzi, F, Guariniello, A, Bonilauri, S, Frazzetta, G, Garino, M, Marafante, C, Gioffre, A, Del Monte, S, Sganga, G, Fransvea, P, Grande, M, Siragusa, L, Sica, G, Paola, M, Passantino, D, Catani, M, Ricci, F, Lauro, E, Facci, E, Parini, D, Armellino, M, Argenio, G, Porcu, A, Perra, T, Bordoni, P, Fleres, F, Parisi, A, Rossi, S, Saracco, R, Bono, D, Viora, T, Orlando, F, Ferrero, A, Fontana, A, De Paolis, P, Visconti, D, Quaglino, F, Festa, F, Palagi, S, Lo Secco, G, Morino, M, Allaix, M, Salzano, A, Tirone, G, Motter, M, Zanus, G, Passuello, N, Massani, M, Tutino, R, Manzini, N, Terranova, S, Merenda, R, Nordio, S, Zonta, S, Lovisetto, F, Guglielmi, A, Campagnaro, T, Amedeo, E, Scollica, M, Amodio, P, Giannotti, D, Olmi, S, and Oldani, A
- Subjects
medicine.medical_specialty ,COVID-19 Pandemic ,Coronavirus disease 2019 (COVID-19) ,Endoscopic surgery ,NO ,Appendectomy ,Appendicitis ,Machine learning ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Postoperative Complications ,Retrospective Studie ,Pandemic ,medicine ,Humans ,Appendiciti ,Laparoscopy ,Pandemics ,Retrospective Studies ,medicine.diagnostic_test ,business.industry ,COVID-19 Pandemic, Appendicitis, Appendicectomy, Machine learning ,SARS-CoV-2 ,COVID-19 ,Length of Stay ,medicine.disease ,Settore MED/18 ,Surgery ,Italy ,030220 oncology & carcinogenesis ,appendicitis ,COVID-19 pandemic ,machine learning ,appendectomy ,cohort studies ,humans ,length of stay ,pandemics ,postoperative complications ,retrospective studies ,laparoscopy ,030211 gastroenterology & hepatology ,Observational study ,Original Article ,Postoperative Complication ,Appendicectomy ,Cohort Studie ,business ,Complication ,Cohort study ,Human - Abstract
Major surgical societies advised using non-operative management of appendicitis and suggested against laparoscopy during the COVID-19 pandemic. The hypothesis is that a significant reduction in the number of emergent appendectomies was observed during the pandemic, restricted to complex cases. The study aimed to analyse emergent surgical appendectomies during pandemic on a national basis and compare it to the same period of the previous year. This is a multicentre, retrospective, observational study investigating the outcomes of patients undergoing emergent appendectomy in March–April 2019 vs March–April 2020. The primary outcome was the number of appendectomies performed, classified according to the American Association for the Surgery of Trauma (AAST) score. Secondary outcomes were the type of surgical technique employed (laparoscopic vs open) and the complication rates. One thousand five hundred forty one patients with acute appendicitis underwent surgery during the two study periods. 1337 (86.8%) patients met the inclusion criteria: 546 (40.8%) patients underwent surgery for acute appendicitis in 2020 and 791 (59.2%) in 2019. According to AAST, patients with complicated appendicitis operated in 2019 were 30.3% vs 39.9% in 2020 (p = 0.001). We observed an increase in the number of post-operative complications in 2020 (15.9%) compared to 2019 (9.6%) (p 24 h after admission (+ 58%), open surgery (+ 112%) and conversion to open surgery (+ 166%). In Italian hospitals, in March and April 2020, the number of appendectomies has drastically dropped. During the first pandemic wave, patients undergoing surgery were more frequently affected by more severe appendicitis than the previous year's timeframe and experienced a higher number of complications. Trial registration number and date: Research Registry ID 5789, May 7th, 2020
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- 2021
5. Combinatory SYBR® Green Real-Time PCR Screening Approach for Tracing Materials Derived from Genetically Modified Rice
- Author
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Kluga, L., Folloni, S., Kagkli, D. M., Bogni, A., Foti, N., Savini, C., Mazzara, M., Van den Eede, G., and Van den Bulcke, M.
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- 2013
- Full Text
- View/download PDF
6. Testing the Robustness of Validated Methods for Quantitative Detection of GMOs Across qPCR Instruments
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Luque-Perez, E., Mazzara, M., Weber, T. P., Foti, N., Grazioli, E., Munaro, B., Pinski, G., Bellocchi, G., Van den Eede, G., and Savini, C.
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- 2013
- Full Text
- View/download PDF
7. FISSIT (Fistula Surgery in Italy) study: A retrospective survey on the surgical management of anal fistulas in Italy over the last 15 years
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Litta, Francesco, Bracchitta, S., Naldini, G., Mistrangelo, M., Tricomi, N., La Torre, M., Altomare, D. F., Mozzon, M., Testa, A., Zigiotto, D., Sica, G., Tutino, R., Lisi, G., Marino, F., Luglio, G., Vergari, R., Terrosu, G., Cantarella, F., Foti, N., Giuliani, A., Moroni, R., Ratto, Carlo, Parello, Angelo, De Simone, V., Bracchitta, L., Sturiale, A., Lo Secco, G., Salomone, S., Velci, L., Picciariello, A., Papagni, V., Caponnetto, F., Folliero, C., Cozza, T., Leopardi, F., Campanelli, M., Divizia, A., Cocorullo, G., D'Agostino, E., Boccuzzi, M., Pezzolla, F., Pagano, G., Mancini, S., Ortenzi, M., Calandra, S., Scarpa, E., Magni, E., Campanile, F. C., Romano, L., Maffione, F., Tierno, S. M., Peltrini, R., Litta F., Ratto C. (ORCID:0000-0002-0556-0037), Parello A., Litta, Francesco, Bracchitta, S., Naldini, G., Mistrangelo, M., Tricomi, N., La Torre, M., Altomare, D. F., Mozzon, M., Testa, A., Zigiotto, D., Sica, G., Tutino, R., Lisi, G., Marino, F., Luglio, G., Vergari, R., Terrosu, G., Cantarella, F., Foti, N., Giuliani, A., Moroni, R., Ratto, Carlo, Parello, Angelo, De Simone, V., Bracchitta, L., Sturiale, A., Lo Secco, G., Salomone, S., Velci, L., Picciariello, A., Papagni, V., Caponnetto, F., Folliero, C., Cozza, T., Leopardi, F., Campanelli, M., Divizia, A., Cocorullo, G., D'Agostino, E., Boccuzzi, M., Pezzolla, F., Pagano, G., Mancini, S., Ortenzi, M., Calandra, S., Scarpa, E., Magni, E., Campanile, F. C., Romano, L., Maffione, F., Tierno, S. M., Peltrini, R., Litta F., Ratto C. (ORCID:0000-0002-0556-0037), and Parello A.
- Abstract
Background: Surgical treatment of anal fistulas is still a challenge. The aims of this study were to evaluate the adoption and healing rates for the different surgical techniques used in Italy over the past 15 years. Methods: This was a multicenter retrospective observational study of patients affected by simple and complex anal fistulas of cryptoglandular origin who were surgically treated in the period 2003–2017. Surgical techniques were grouped as sphincter-cutting or sphincter-sparing and as technology-assisted or techno-free. All patients included in the study were followed for at least 12 months. Results: A total of 9,536 patients (5,520 simple; 4,016 complex fistulas) entered the study. For simple fistulas, fistulotomy was the most frequently used procedure, although its adoption significantly decreased over the years (P < .0005), with an increase in sphincter-sparing approaches; the overall healing rate in simple fistulas was 81.1%, with a significant difference between sphincter-cutting (91.9%) and sphincter-sparing (65.1%) techniques (P = .001). For complex fistulas, the adoption of sphincter-cutting approaches decreased, while sphincter-sparing techniques were mildly preferred (P < .0005). Moreover, there was a significant trend toward the use of technology-assisted procedures. The overall healing rate for complex fistulas was 69.0%, with a measurable difference between sphincter-cutting (81.1%) and sphincter-sparing (61.4%; P = .001) techniques and between techno-free and technology-assisted techniques (72.5% and 55.0%, respectively; P = .001). Conclusion: Surgical treatment of anal fistulas has changed, with a trend toward the use of sphincter-sparing techniques. The overall cure rate has remained stable, even if the most innovative procedures have achieved a lower success rate.
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- 2021
8. FISSIT (Fistula Surgery in Italy) study: A retrospective survey on the surgical management of anal fistulas in Italy over the last 15 years
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Litta, F., Bracchitta, S., Naldini, G., Mistrangelo, M., Tricomi, N., La Torre, M., Altomare, D. F., Mozzon, M., Testa, A., Zigiotto, D., Sica, G., Tutino, R., Lisi, G., Marino, F., Luglio, G., Vergari, R., Terrosu, G., Cantarella, F., Foti, N., Giuliani, A., Moroni, R., Ratto, C., Parello, A., De Simone, V., Bracchitta, L., Sturiale, A., Lo Secco, G., Salomone, S., Velci, L., Picciariello, A., Papagni, V., Caponnetto, F., Folliero, C., Cozza, T., Leopardi, F., Campanelli, M., Divizia, A., Cocorullo, G., D'Agostino, E., Boccuzzi, M., Pezzolla, F., Pagano, G., Mancini, S., Ortenzi, M., Calandra, S., Scarpa, E., Magni, E., Campanile, F. C., Romano, L., Maffione, F., Tierno, S. M., Peltrini, R., Litta F., La Torre M., Testa A. (ORCID:0000-0003-2217-8726), Marino F., Giuliani A. (ORCID:0000-0002-0773-2162), Ratto C. (ORCID:0000-0002-0556-0037), Parello A., Mancini S., Magni E. (ORCID:0000-0002-2235-2280), Litta, F., Bracchitta, S., Naldini, G., Mistrangelo, M., Tricomi, N., La Torre, M., Altomare, D. F., Mozzon, M., Testa, A., Zigiotto, D., Sica, G., Tutino, R., Lisi, G., Marino, F., Luglio, G., Vergari, R., Terrosu, G., Cantarella, F., Foti, N., Giuliani, A., Moroni, R., Ratto, C., Parello, A., De Simone, V., Bracchitta, L., Sturiale, A., Lo Secco, G., Salomone, S., Velci, L., Picciariello, A., Papagni, V., Caponnetto, F., Folliero, C., Cozza, T., Leopardi, F., Campanelli, M., Divizia, A., Cocorullo, G., D'Agostino, E., Boccuzzi, M., Pezzolla, F., Pagano, G., Mancini, S., Ortenzi, M., Calandra, S., Scarpa, E., Magni, E., Campanile, F. C., Romano, L., Maffione, F., Tierno, S. M., Peltrini, R., Litta F., La Torre M., Testa A. (ORCID:0000-0003-2217-8726), Marino F., Giuliani A. (ORCID:0000-0002-0773-2162), Ratto C. (ORCID:0000-0002-0556-0037), Parello A., Mancini S., and Magni E. (ORCID:0000-0002-2235-2280)
- Abstract
Background: Surgical treatment of anal fistulas is still a challenge. The aims of this study were to evaluate the adoption and healing rates for the different surgical techniques used in Italy over the past 15 years. Methods: This was a multicenter retrospective observational study of patients affected by simple and complex anal fistulas of cryptoglandular origin who were surgically treated in the period 2003–2017. Surgical techniques were grouped as sphincter-cutting or sphincter-sparing and as technology-assisted or techno-free. All patients included in the study were followed for at least 12 months. Results: A total of 9,536 patients (5,520 simple; 4,016 complex fistulas) entered the study. For simple fistulas, fistulotomy was the most frequently used procedure, although its adoption significantly decreased over the years (P < .0005), with an increase in sphincter-sparing approaches; the overall healing rate in simple fistulas was 81.1%, with a significant difference between sphincter-cutting (91.9%) and sphincter-sparing (65.1%) techniques (P = .001). For complex fistulas, the adoption of sphincter-cutting approaches decreased, while sphincter-sparing techniques were mildly preferred (P < .0005). Moreover, there was a significant trend toward the use of technology-assisted procedures. The overall healing rate for complex fistulas was 69.0%, with a measurable difference between sphincter-cutting (81.1%) and sphincter-sparing (61.4%; P = .001) techniques and between techno-free and technology-assisted techniques (72.5% and 55.0%, respectively; P = .001). Conclusion: Surgical treatment of anal fistulas has changed, with a trend toward the use of sphincter-sparing techniques. The overall cure rate has remained stable, even if the most innovative procedures have achieved a lower success rate.
- Published
- 2021
9. Bahren types III and IVa testicular vein anomalies as a reason for failure in left idiopathic varicocele retrograde sclerotherapy. Ontogenic discussion and clinical implications
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Forte, F., Latini, M., Foti, N., Sorrenti, S., De Antoni, E., Virgili, G., Vespasiani, G., and Bronzetti, E.
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- 2002
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- View/download PDF
10. Inflammatory pseudotumor of the bladder: etiopathologic and clinical features
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Forte, F, Foti, N, Bronzetti, Elena, Catania, Antonio, D'Andrea, Vito, Sorrenti, Salvatore, Vespasiani, G, Mordente, S, DE ANTONI, Enrico, Forte, F, Foti, N, Bronzetti, E, Catania, A, D'Andrea, V, Sorrenti, S, Vespasiani, G, Mordente, Settimio, and DE ANTONI, E.
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pseudohistiocytic neoplasm ,Urinary Bladder Diseases ,bladder tumours ,Humans ,inflammatory pseudotumour ,Female ,Middle Aged ,Granuloma, Plasma Cell - Abstract
The Authors present a case of inflammatory pseudotumour (IPT) of the urinary bladder occurring in a 57-year-old female patient, who was referred to our department with haematuria, stranguria and hypogastric pain. Ultrasonographic, radiological and endoscopic examinations showed a sessile, ulcerated, easily bleeding bladder formation; urinary cytology revealed no atypical transitional cells. Abdomino-pelvic computed tomography analysis showed thickening of the bladder walls and infiltration of the perivesical fat. Histopathologically, the formation was indicated as an inflammatory pseudotumour (IPT) of the bladder. The patient underwent TURB (transurethral resection of the bladder) and was discharged clinically healed on postoperative day 4. A one-year follow up revealed no evidence of recurrence. On the basis of their experience and a thorough review of the literature review, the Authors discuss the clinico-pathological features of IPT of the bladder and the possible factors involved in the malignant transformation of IPT. In conclusion, the benign nature of the lesion is stressed.
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- 2001
11. Contestuale artrodesi e artroplastica cervicale: tecniche contrapposte o complementari?
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Barbagallo, GIUSEPPE MARIA, Assietti, °. R., Corbino, L., Olindo, G., Foti, N. P. l. a. t. a. n. i. a. P., Russo, V., and Albanese, V.
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- 2008
12. Untersuchung über die Überwinterung von Weiseln außerhalb der Traube und ihre Verwendung in der Produktion
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Foti, N., primary, Barac, I., additional, Alexandru, V., additional, and Mirza, E., additional
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- 1962
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- View/download PDF
13. Purulent meningitis due to spontaneous anterior sacral meningocele perforation. Case report
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Fiumara F., Foti N., Gambardella A., Mazzeo A., Oliveri R. L., Pagano V. D., and Quattrone A.
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- 1989
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- View/download PDF
14. Ontogenesis of congenital abnormalities of the left gonadal vein and their clinical relevance [Ontogenesi delle anomalie congenite della vena gonadica sinistra e loro rilevanza clinica.]
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Forte, F., Salvatore SORRENTI, Felici, L. M., Carbotta, S., Foti, N., Falvo, L., Vanni, B., Biancafarina, A., Catania, A., and Bronzetti, E.
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varicocele ,Adult ,Male ,congenital malformation ,article ,gonad ,cadaver ,Veins ,Settore MED/34 - Medicina Fisica e Riabilitativa ,female ,vascularization ,vein ,case report ,Humans ,pathology ,human ,adult ,male ,Cadaver ,Female ,Gonads ,Varicocele - Published
- 2003
15. Testicular fixation in adult retractile testis: technical notes
- Author
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Forte, F., Bitelli, M., Salvatore SORRENTI, Spinelli, G. L., Foti, N., Ciotola, O., Pietrantuono, F., Catania, A., and Micali, F.
- Subjects
Settore MED/34 - Medicina Fisica e Riabilitativa ,Adult ,Male ,adolescent ,adult ,article ,human ,male ,methodology ,testis torsion ,urologic surgery ,Adolescent ,Humans ,Spermatic Cord Torsion ,Urogenital Surgical Procedures - Published
- 2003
16. Validità e limiti del dosaggio rapido del paratormone nell’iperparatiroidismo primario e secondario
- Author
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Sorrenti, Salvatore, Falvo, L, Foti, N, Vanni, B, Biancafarina, Alessia, and Polichetti, Pe
- Published
- 2002
17. Retroperitoneal lipoma: Unusual presentation with detrusor instability
- Author
-
Forte, F., Maturo, G., Catania, A., Salvatore SORRENTI, Gemma, D., Foti, N., Vanni, B., Virgili, G., Vespasiani, G., and Antoni, E.
- Subjects
Male ,diagnosis ,Bladder ,bladder ,lipoma ,surgery ,retroperitoneal neoplasms ,Middle Aged ,Settore MED/24 - Urologia ,Lipoma, diagnosis ,Lipoma, surgery ,Retroperitoneal neoplasms, diagnosis ,Urodynamics ,Urinary Incontinence ,Retroperitoneal neoplasms ,Humans ,Lipoma ,Gait Disorders, Neurologic ,Ultrasonography - Abstract
Retroperitoneal lipomas are a heterogeneous group of mesenchymal tumors. They are usually large and occur most frequently in the retroperitoneal, perineal and pelvic regions. Lipomas grow slowly surrounding the retroperitoneal and pelvic organs, with a displacement of bowel and vascular axis. A case of a 61-year-old male patient which referred urinary frequency, urgency and nocturia is presented. Urodynamics evidenced a detrusor instability in a low capacity bladder. CT scan demonstrated a bladder dome compression due to a huge retroperitoneal mass extending from the right hepatic lobe to the hypogastric region and the right thigh. Surgical complete resection was performed: histology demonstrated a lipoma with areas of well differentiated myxoid degeneration. After surgery the irritative urinary symptoms disappeared. This is the first case described in literature of detrusor instability due to bladder compression by retroperitoneal lipoma.
- Published
- 2002
18. Trattamento degli iperparatiroidismi persistenti e recidivi
- Author
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Falvo, L, Sorrenti, Salvatore, Foti, N, Dibra, A, Biancafarina, Alessia, Jonatana, E, and Catania, Antonio
- Published
- 2001
19. Prostatic small cell carcinoma dignosed by tru-cut needle biopsy: discussion of clinico-pathologicalfindings
- Author
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Iavarone, C, Forte, F, Foti, N, Catania, A, D'Andrea, V, Sorrenti, S, Vespasiani, G, Virgili, G, D'Amico, F, and De Antoni, E
- Subjects
Settore MED/24 - Urologia - Published
- 2001
20. Il trattamento chirurgico degli iperparatiroidismi: esperienza di scuola
- Author
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Catania, Antonio, Sorrenti, Salvatore, Falvo, L, Leo, E, and Foti, N.
- Published
- 2001
21. Granular cell tumors (abrikossoff's tumors) of the chest wall and intrathoracic organs
- Author
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Biancari, F., D'Andrea, Vito, Catania, Antonio, Leo, E., Foti, N., Polichetti, P. E., and Juvonen, T.
- Subjects
INVOLVEMENT ,MYOBLASTOMA ,ESOPHAGUS - Published
- 2001
22. Trattamento chirurgico dell’iperparatiroidismo primario
- Author
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Foti, N, Sorrenti, Salvatore, DI MATTEO, Filippo Maria, Dibra, A, Forte, F, Catania, Antonio, and DE ANTONI, Enrico
- Published
- 2001
23. THYROID NODULES: COMPARISON OF PREOPERATIVE AND INTRAOPERATIVE NEEDLE AND DEFINITE HISTOLOGICAL STUDY
- Author
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D'Andrea, Vito, Redler, Adriano, Calo', P, Donati, L, Foti, N, Falvo, L, and DE ANTONI, Enrico
- Published
- 2000
24. Surgical importance of anatomical variations in extrahepatic biliary ducts and vessels
- Author
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Felici, Lm, Bronzetti, E, D'Andrea, Vito, Forte, F, Foti, N, Gemma, D, D'Addario, M, and Rossodivita, I.
- Published
- 1999
25. Preneural or total parotidectomy?
- Author
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Falvo, L, Sorrenti, Salvatore, Catania, Antonio, D'Andrea, Vito, Dibra, A, Foti, N, and DE ANTONI, Enrico
- Published
- 1999
26. SURGICAL TREATMENT FOR PRIMARY HYPERPARATHYROIDISM
- Author
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Sorrenti, Salvatore, Falvo, L., Catania, Antonio, D'Andrea, Vito, Dibra, A., Foti, N., and DE ANTONI, Enrico
- Published
- 1999
27. Interposition vein cuff in infrainguinal prosthetic bypasses
- Author
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D Andrea, V., Fausto Biancari, Catania, A., Di Matteo, F. M., Sorrenti, S., Spyrou, M., Dibra, A., Foti, N., and Ortensi, A.
- Subjects
Leg ,Hyperplasia ,Time Factors ,Anastomosis, Surgical ,Arteries ,Prosthesis Design ,Blood Vessel Prosthesis ,Veins ,Ischemia ,Humans ,anastomosis ,intimal hyperplasia ,miller's cuff ,prosthetic graft ,vein cuff ,Tunica Intima ,Polytetrafluoroethylene ,Vascular Patency ,Follow-Up Studies - Abstract
The Authors describe the interposition vein cuff technique as an adjuvant method to infrainguinal prosthetic bypass grafts. The haemodynamic, mechanical and humoral factors thought to be involved in the beneficial effects of the vein cuff are herein discussed. The results of the main series suggest the use of this method particularly in patients without any available autologous vein conduit requiring a below-knee popliteal or crural reconstruction.
- Published
- 1999
28. Studio della reazione 12C(6Li,α 12C)2H come approccio indiretto alla 12C(α,γ)16O :implicazioni astrofisiche
- Author
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Aliotta, M., Cappuzzello, Francesco, Cunsolo, A., Lattuada, Marcello, Pizzone, R. G., Putaggio, L., Romano, Stefano, Spitaleri, C, Costanzo, E., Foti, N., and Zappala', R. A.
- Published
- 1998
29. Venous drainage patterns of the stomach in some orders,families and species of laboratory mammals
- Author
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Dibra, A, Marcellino, V, Foti, N, Spyrou, M, and D'Andrea, Vito
- Subjects
Venous drainage, stomach, laboratory ,Venous drainage ,laboratory ,stomach - Published
- 1998
30. Combinatory SYBR® Green Real-Time PCR Screening Approach for Tracing Materials Derived from Genetically Modified Rice
- Author
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Kluga, L., primary, Folloni, S., additional, Kagkli, D. M., additional, Bogni, A., additional, Foti, N., additional, Savini, C., additional, Mazzara, M., additional, Van den Eede, G., additional, and Van den Bulcke, M., additional
- Published
- 2012
- Full Text
- View/download PDF
31. Testing the Robustness of Validated Methods for Quantitative Detection of GMOs Across qPCR Instruments
- Author
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Luque-Perez, E., primary, Mazzara, M., additional, Weber, T. P., additional, Foti, N., additional, Grazioli, E., additional, Munaro, B., additional, Pinski, G., additional, Bellocchi, G., additional, Van den Eede, G., additional, and Savini, C., additional
- Published
- 2012
- Full Text
- View/download PDF
32. MRI detection of changes during liver regeneration by T-null inversion recovery technique [MODELLO ANIMALE PER LO STUDIO DELLA RIGENERAZIONE EPATICA IN RISONANZA MAGNETICA PER IMMAGINI]
- Author
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Patrizio, G, Pietroletti, Renato, Pavone, P, Foti, N, Tettamanti, E, Ventura, T, Simi, M, and Passariello, R.
- Published
- 1990
33. Ontogenesis of congenital abnormalities of the left gonadal vein and their clinical relevance,Ontogenesi delle anomalie congenite della vena gonadica sinistra e loro rilevanza clinica
- Author
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Forte, F., Sorrenti, S., Felici, L. M., CARBOTTA SABINO, Foti, N., Falvo, L., Vanni, B., Biancafarina, A., Catania, A., and Bronzetti, E.
34. Targeting Representation: Interpreting Calls for Diversity in Precision Medicine Research
- Author
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Lee, S. S. -J, Fullerton, S. M., Mcmahon, C. E., Bentz, M., Aliya Saperstein, Jeske, M., Vasquez, E., Foti, N., Saco, L., and Shim, J. K.
35. Prostatic small cell carcinoma diagnosed by tru-cut needle biopsy: discussion of clinico-pathological findings
- Author
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Iavarone, C., Forte, F., Foti, N., Catania, A., D Andrea, V., Salvatore SORRENTI, Vespasiani, G., Virgili, G., D Amico, F., and Antoni, E.
- Subjects
Male ,Biopsy, Needle ,Humans ,Prostatic Neoplasms ,Carcinoma, Small Cell ,Aged - Abstract
The small cell carcinoma is a neuroendocrine tumour characterised by an aggressive clinical course and a high mortality rate. It occurs most commonly in the lung. Small cell carcinomas originating in the genitourinary system have been diagnosed with increasing frequency in recent years, because of the use of immunohistochemistry. Prostatic small cell carcinomas present the same biological behavior and similar histological, immunohistochemical and ultrastructural features to small cell carcinomas of the lungs. We describe the clinico-pathological findings in a 65-year-old male patient with a diagnosis of prostatic small cell carcinoma, obtained by means of a tru-cut needle biopsy. We performed the immunohistochemical tests using neuron-specific enolase and chromogranin A antibodies, according to the literature. On the basis of our experience we stress the malignant features of small cell carcinoma and the difficulty in obtaining an early diagnosis and treatment because of the aggressive course of the lesion and the late symptomatology.
36. Transduodenal excision of giant tumour of the ampulla of Vater: a case report
- Author
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Antonio CATANIA, Falvo, L., D Andrea, V., Sorrenti, S., Dibra, A., Foti, N., Biancafarina, A., Vanni, B., and Antoni, E.
- Subjects
Male ,ampulla of vater ,Biliary Tract Surgical Procedures ,adenocarcinoma ,ampullectomy ,Common Bile Duct Neoplasms ,Humans ,Aged - Abstract
Carcinoma of the papilla is a rare cancer of the digestive tract; 5% of all gastrointestinal tract malignant neoplasms are periampullary. The authors report and discuss the case of one of their patients aged 79 years suffering from a tumour of the papilla. The case was characterized by the large size of the neoplasm (5.5 cm in diameter) and by the poor clinical conditions of the patient, who was suffering from Parkinson's disease and was at high operative risk. The surgical strategy chosen involved transduodenal excision of the tumour with duodenum-bile duct anastomosis and internal duodenum-Wirsung duct anastomosis. The authors first examine the hypothesis that carcinoma of the papilla may represent the evolution of an adenomatous lesion and then go on to assess the therapeutic strategy adopted in the treatment of these neoplasms: in patients at high operative risk a transduodenal excision of the tumour with duodenum-bile duct anastomosis and internal duodenum-Wirsung duct anastomosis may be a valid alternative to the conventional Whipple procedure.
37. Synchronous bilateral renal tumour: a case report
- Author
-
Falvo, L., Berni, A., Antonio CATANIA, Dibra, A., Foti, N., Sorrenti, S., Stefano, M., Forte, F., Palermo, S., and Antoni, E.
- Subjects
Male ,Neoplasms, Multiple Primary ,carcinoma renale bilaterale ,nefrectomia ,Humans ,Middle Aged ,Carcinoma, Renal Cell ,Nephrectomy ,Kidney Neoplasms - Abstract
We report a case of synchronous bilateral renal carcinoma treated by partial nephrectomy on the right and total nephrectomy on the left. Follow-up at 42 months after surgery showed no recurrence of the disease. The increasing use of diagnostic imaging techniques such as ultrasound tomography, computerised tomography and nuclear magnetic resonance now allows even small-sized renal formations to be identified. Synchronous bilateral renal tumour has a favourable prognosis, especially when compared with single or asynchronous renal tumours. The recommended intervention is total monolateral nephrectomy combined with partial nephrectomy. The treatment of neoplasms at a more advanced stage, of such a nature as to necessitate bilateral nephrectomy or chemotherapy, results in a significant increase in mortality. Recently, biological therapy has been proposed as a more promising short-term option using interferon-alpha (IFN-alpha) and gamma.
38. Testing the interaction between analytical modules: an example with Roundup Ready® soybean line GTS 40-3-2
- Author
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Bellocchi Gianni, De Giacomo Marzia, Foti Nicoletta, Mazzara Marco, Palmaccio Eleonora, Savini Cristian, Di Domenicantonio Chiara, Onori Roberta, and Van den Eede Guy
- Subjects
Biotechnology ,TP248.13-248.65 - Abstract
Abstract Background The modular approach to analysis of genetically modified organisms (GMOs) relies on the independence of the modules combined (i.e. DNA extraction and GM quantification). The validity of this assumption has to be proved on the basis of specific performance criteria. Results An experiment was conducted using, as a reference, the validated quantitative real-time polymerase chain reaction (PCR) module for detection of glyphosate-tolerant Roundup Ready® GM soybean (RRS). Different DNA extraction modules (CTAB, Wizard and Dellaporta), were used to extract DNA from different food/feed matrices (feed, biscuit and certified reference material [CRM 1%]) containing the target of the real-time PCR module used for validation. Purity and structural integrity (absence of inhibition) were used as basic criteria that a DNA extraction module must satisfy in order to provide suitable template DNA for quantitative real-time (RT) PCR-based GMO analysis. When performance criteria were applied (removal of non-compliant DNA extracts), the independence of GMO quantification from the extraction method and matrix was statistically proved, except in the case of Wizard applied to biscuit. A fuzzy logic-based procedure also confirmed the relatively poor performance of the Wizard/biscuit combination. Conclusions For RRS, this study recognises that modularity can be generally accepted, with the limitation of avoiding combining highly processed material (i.e. biscuit) with a magnetic-beads system (i.e. Wizard).
- Published
- 2010
- Full Text
- View/download PDF
39. FISSIT (Fistula Surgery in Italy) study: A retrospective survey on the surgical management of anal fistulas in Italy over the last 15 years
- Author
-
Marco La Torre, Edoardo Scarpa, Cristina Folliero, Lucia Romano, Alessandro Testa, Gabriele Naldini, Roberta Tutino, Veronica De Simone, Francesco Pezzolla, Arcangelo Picciariello, Giorgio Lisi, Donato F. Altomare, Elio D’Agostino, Filippo Caponnetto, Marta Mozzon, Tiziana Cozza, Francesco Cantarella, Monica Ortenzi, Massimiliano Mistrangelo, Giacomo Lo Secco, Stefano Mancini, Enrico Magni, Fulvio Leopardi, Gaetano Luglio, Gianfranco Cocorullo, Giuseppe Sica, Roberto Vergari, Vincenzo Papagni, Luigi Bracchitta, Angelo Parello, Nicola Tricomi, Fabio Marino, Simone Maria Tierno, Massimiliano Boccuzzi, Antonio Giuliani, Nicola Foti, Francesco Litta, Alessandro Sturiale, Gianluca Pagano, Fabio Cesare Campanile, Luigi Velci, Sara Salomone, Giovanni Terrosu, Roberto Peltrini, Rossana Moroni, Salvatore Bracchitta, Francesco Maffione, Michela Campanelli, Carlo Ratto, Sergio Calandra, Andrea Divizia, Daniele Zigiotto, Litta, F., Bracchitta, S., Naldini, G., Mistrangelo, M., Tricomi, N., La Torre, M., Altomare, D. F., Mozzon, M., Testa, A., Zigiotto, D., Sica, G., Tutino, R., Lisi, G., Marino, F., Luglio, G., Vergari, R., Terrosu, G., Cantarella, F., Foti, N., Giuliani, A., Moroni, R., Ratto, C., Parello, A., De Simone, V., Bracchitta, L., Sturiale, A., Lo Secco, G., Salomone, S., Velci, L., Picciariello, A., Papagni, V., Caponnetto, F., Folliero, C., Cozza, T., Leopardi, F., Campanelli, M., Divizia, A., Cocorullo, G., D'Agostino, E., Boccuzzi, M., Pezzolla, F., Pagano, G., Mancini, S., Ortenzi, M., Calandra, S., Scarpa, E., Magni, E., Campanile, F. C., Romano, L., Maffione, F., Tierno, S. M., and Peltrini, R.
- Subjects
Anal fistula ,Male ,medicine.medical_specialty ,Cure rate ,Fistula ,Settore MED/18 - CHIRURGIA GENERALE ,Anal Canal ,Fecal Incontinence ,Female ,Follow-Up Studies ,Humans ,Incidence ,Italy ,Middle Aged ,Population Surveillance ,Postoperative Complications ,Rectal Fistula ,Retrospective Studies ,Forecasting ,Fistulotomy ,Follow-Up Studie ,Retrospective survey ,Retrospective Studie ,medicine ,Surgical treatment ,anorectal fistula ,business.industry ,Retrospective cohort study ,medicine.disease ,Surgery ,Settore MED/18 ,Postoperative Complication ,business ,Human - Abstract
Background: Surgical treatment of anal fistulas is still a challenge. The aims of this study were to evaluate the adoption and healing rates for the different surgical techniques used in Italy over the past 15 years. Methods: This was a multicenter retrospective observational study of patients affected by simple and complex anal fistulas of cryptoglandular origin who were surgically treated in the period 2003–2017. Surgical techniques were grouped as sphincter-cutting or sphincter-sparing and as technology-assisted or techno-free. All patients included in the study were followed for at least 12 months. Results: A total of 9,536 patients (5,520 simple; 4,016 complex fistulas) entered the study. For simple fistulas, fistulotomy was the most frequently used procedure, although its adoption significantly decreased over the years (P < .0005), with an increase in sphincter-sparing approaches; the overall healing rate in simple fistulas was 81.1%, with a significant difference between sphincter-cutting (91.9%) and sphincter-sparing (65.1%) techniques (P = .001). For complex fistulas, the adoption of sphincter-cutting approaches decreased, while sphincter-sparing techniques were mildly preferred (P < .0005). Moreover, there was a significant trend toward the use of technology-assisted procedures. The overall healing rate for complex fistulas was 69.0%, with a measurable difference between sphincter-cutting (81.1%) and sphincter-sparing (61.4%; P = .001) techniques and between techno-free and technology-assisted techniques (72.5% and 55.0%, respectively; P = .001). Conclusion: Surgical treatment of anal fistulas has changed, with a trend toward the use of sphincter-sparing techniques. The overall cure rate has remained stable, even if the most innovative procedures have achieved a lower success rate.
- Published
- 2021
40. EVALUATION OF SAMPLING CRITERIA FOR THE DETECTION OF GM SOYBEANS IN BULK.
- Author
-
Brera, C., Donnarumma, E., Onori, R., Foti, N., Pazzaglini, B., and Miraglia, M.
- Subjects
- *
GENETICALLY modified foods , *SOYBEAN , *TRANSGENIC organisms , *SAMPLING (Process) - Abstract
The aim of this study was to develop a sampling procedure to quantify genetically-modified Round-up Ready (GM RR) soybeans in a lot. Seven lots (35 kg each) fortified with three different percentages of GM RR soybeans (4 lots at 1%, 2 lots at 10%, and 1 lot at 5%) were prepared. Four sampling procedures were carried out on each lot. Different numbers and sizes of increment samples were collected from the lots tested and prepared by homogenising the sample with water. Separate analyses were carried out using quantitative Real Time PCR of split aliquots. The sampling procedures that used ten increment samples provided the best results, in terms of precision and accuracy. [ABSTRACT FROM AUTHOR]
- Published
- 2005
41. Using a linear dynamic system to measure functional connectivity from M/EEG.
- Author
-
Drew J, Foti N, Nadkarni R, Larson E, Fox E, and Kc Lee A
- Subjects
- Humans, Male, Female, Adult, Acoustic Stimulation methods, Young Adult, Linear Models, Auditory Perception physiology, Auditory Cortex physiology, Magnetoencephalography methods, Nerve Net physiology, Electroencephalography methods, Attention physiology
- Abstract
Objective. Measures of functional connectivity (FC) can elucidate which cortical regions work together in order to complete a variety of behavioral tasks. This study's primary objective was to expand a previously published model of measuring FC to include multiple subjects and several regions of interest. While FC has been more extensively investigated in vision and other sensorimotor tasks, it is not as well understood in audition. The secondary objective of this study was to investigate how auditory regions are functionally connected to other cortical regions when attention is directed to different distinct auditory stimuli. Approach. This study implements a linear dynamic system (LDS) to measure the structured time-lagged dependence across several cortical regions in order to estimate their FC during a dual-stream auditory attention task. Results. The model's output shows consistent functionally connected regions across different listening conditions, indicative of an auditory attention network that engages regardless of endogenous switching of attention or different auditory cues being attended. Significance. The LDS implemented in this study implements a multivariate autoregression to infer FC across cortical regions during an auditory attention task. This study shows how a first-order autoregressive function can reliably measure functional connectivity from M/EEG data. Additionally, the study shows how auditory regions engage with the supramodal attention network outlined in the visual attention literature., (© 2024 IOP Publishing Ltd.)
- Published
- 2024
- Full Text
- View/download PDF
42. Sodium and Human Health: What Can Be Done to Improve Sodium Balance beyond Food Processing?
- Author
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Tremblay A, Gagné MP, Pérusse L, Fortier C, Provencher V, Corcuff R, Pomerleau S, Foti N, and Drapeau V
- Subjects
- Humans, Diet, Healthy methods, Exercise physiology, Healthy Lifestyle, Sodium, Dietary administration & dosage, Food Handling methods
- Abstract
Sodium plays a key role in the regulation of water balance and is also important in food formulation due to its contribution to the taste and use in the preservation of many foods. Excessive intake of any essential nutrient is problematic and this seems to be particularly the case for sodium since a high intake makes it the nutrient most strongly associated with mortality. Sodium intake has been the object of recommendations by public health agencies such as the WHO and this has resulted in efforts by the food industry to reduce the sodium content of packaged foods, although there is still room for improvement. The recent literature also emphasizes the need for other strategies, e.g., regulations and education, to promote adequate sodium intake. In the present paper, we also describe the potential benefits of a global healthy lifestyle that considers healthy eating but also physical activity habits that improve body functionality and may help to attenuate the detrimental effects of high sodium intake on body composition and cardiometabolic health. In conclusion, a reduction in sodium intake, an improvement in body functioning, and educational interventions promoting healthy eating behaviours seem to be essential for the optimal regulation of sodium balance.
- Published
- 2024
- Full Text
- View/download PDF
43. Interrogating the Value of Return of Results for Diverse Populations: Perspectives from Precision Medicine Researchers.
- Author
-
McMahon CE, Foti N, Jeske M, Britton WR, Fullerton SM, Shim JK, and Lee SS
- Subjects
- Humans, Cultural Diversity, Biomedical Research ethics, Research Subjects, Disclosure, Qualitative Research, Precision Medicine, Research Personnel
- Abstract
Background: Over the last decade, the return of results (ROR) in precision medicine research (PMR) has become increasingly routine. Calls for individual rights to research results have extended the "duty to report" from clinically useful genetic information to traits and ancestry results. ROR has thus been reframed as inherently beneficial to research participants, without a needed focus on who benefits and how. This paper addresses this gap, particularly in the context of PMR aimed at increasing participant diversity, by providing investigator and researcher perspectives on and questions about the assumed value of ROR in PMR., Methods: Semi-structured interviews with a purposive sample of investigators and researchers across federally funded PMR studies in three national consortia, as well as observations of study activities, focused on how PM researchers conceptualize diversity and implement inclusive practices across research stages, including navigating ROR., Results: Interviewees (1) validated the value of ROR as a benefit of PMR, while others (2) questioned the benefit of clinically actionable results to individuals in the absence of sufficient resources for translating findings into health care for diverse and disadvantaged populations; (3) expressed uncertainties in applying the presumed value of ROR as a benefit for non- clinical results; and (4) and debated when the promise of the value of ROR may undermine trust in PMR, and divert efforts to return value beyond ROR., Conclusions: Conceptualizations of diversity and inclusion among PM researchers and investigators raise unique ethical questions where unexamined assumptions of the value of ROR inform study recruitment efforts to enroll minoritized and under-represented populations. A lack of consideration for resources and infrastructure necessary to translate ROR into actionable information may hinder trustworthy community-research relationships. Thus, we argue for a more intentional interrogation of ROR practices as an offer of benefit and for whom.
- Published
- 2024
- Full Text
- View/download PDF
44. Presumed Takotsubo syndrome is associated with high in-hospital mortality in very elderly frail females: a case series.
- Author
-
Sonaglioni A, Lombardo M, Grasso E, Nicolosi GL, Foti N, Lonati C, and Harari S
- Subjects
- Aged, 80 and over, Aged, Humans, Female, Hospital Mortality, Frail Elderly, Coronary Angiography, Takotsubo Cardiomyopathy complications, Takotsubo Cardiomyopathy diagnosis, Frailty complications
- Abstract
Given the aging of general population, very elderly females with Takotsubo syndrome (TTS) are not rarely encountered in clinical practice. Although coronary angiography with left ventriculography is the gold standard diagnostic tool to exclude or confirm TTS, currently, this invasive procedure is less frequently performed in older patients with several comorbidities, such as renal failure, anemia, infections, neurological disorders, malignancy, and severe frailty. In these patients, a "presumed" TTS is diagnosed on the basis of clinical presentation, electrocardiogram, cardiac biomarkers, and echocardiographic findings without coronary angiography. While, in younger patients, TTS is generally a benign condition, in very elderly females, it is associated with higher in-hospital mortality and poor prognosis. Herein, we present four cases of ultra-octogenarian females diagnosed with "presumed TTS", who did not undergo coronary angiography due to severe frailty and multiple comorbidities and who exhibited poor outcome. This could arise the question if an early more aggressive approach could have changed final results. Probably, the solution could only be a personalized decision deriving from a profound and detailed discussion of each case through a multidisciplinary team approach., (© 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.)
- Published
- 2023
- Full Text
- View/download PDF
45. Community Engagement in Precision Medicine Research: Organizational Practices and Their Impacts for Equity.
- Author
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Shim JK, Foti N, Vasquez E, Fullerton SM, Bentz M, Jeske M, and Lee SS
- Subjects
- Humans, Precision Medicine, Community-Based Participatory Research, Data Collection, Community Participation, Biomedical Research
- Abstract
Background: In the wake of mandates for biomedical research to increase participation by members of historically underrepresented populations, community engagement (CE) has emerged as a key intervention to help achieve this goal., Methods: Using interviews, observations, and document analysis, we examine how stakeholders in precision medicine research understand and seek to put into practice ideas about who to engage, how engagement should be conducted, and what engagement is for., Results: We find that ad hoc, opportunistic, and instrumental approaches to CE exacted significant consequences for the time and resources devoted to engagement and the ultimate impacts it has on research. Critical differences emerged when engagement and research decisionmaking were integrated with each other versus occurring in parallel, separate parts of the study organization, and whether community members had the ability to determine which issues would be brought to them for consideration or to revise or even veto proposals made upstream based on criteria that mattered to them. CE was understood to have a range of purposes, from instrumentally facilitating recruitment and data collection, to advancing community priorities and concerns, to furthering long-term investments in relationships with and changes in communities. These choices about who to engage, what engagement activities to support, how to solicit and integrate community input into the workflow of the study, and what CE was for were often conditioned upon preexisting perceptions and upstream decisions about study goals, competing priorities, and resource availability., Conclusions: Upstream choices about CE and constraints of time and resources cascade into tradeoffs that often culminated in "pantomime community engagement." This approach can create downstream costs when engagement is experienced as improvised and sporadic. Transformations are needed for CE to be seen as a necessary scientific investment and part of the scientific process.
- Published
- 2023
- Full Text
- View/download PDF
46. Rethinking Benefit and Responsibility in the Context of Diversity: Perspectives from the Front Lines of Precision Medicine Research.
- Author
-
Vasquez EE, Foti N, McMahon CE, Jeske M, Bentz M, Fullerton S, Shim JK, and Lee SS
- Subjects
- Humans, Academies and Institutes, Precision Medicine, Ethics, Research
- Abstract
Introduction: Federal agencies have instituted guidelines to prioritize the enrollment and retention of diverse participants in precision medicine research (PMR). Prior studies examining participation of minoritized communities have shown that potential benefits represent a key determinant. Human subject research guidance, however, conceptualizes potential benefits narrowly, emphasizing generalized advances in medical knowledge. Further, few studies have provided qualitative data that critically examine how the concept of "benefit" is interpreted or challenged in the context of research practice. This paper examines the experiences of PMR investigators and frontline research staff to understand how standard approaches to benefit are received, contested, and negotiated "on the ground.", Methods: Findings are drawn from a qualitative project conducted across five US-based, federally funded PMR studies. Data collection included 125 in-depth interviews with a purposive sample of investigators, research staff, community advisory board members, and NIH program officers associated with these PMR studies., Results: Researchers report that the standard approach to benefit - which relies on the premise of altruism and the promise of incrementally advancing scientific knowledge - is frequently contested. Researchers experience moral distress over the unmet clinical, psychosocial, and material needs within the communities they are engaging. Many believe the broader research enterprise has a responsibility to better address these needs., Conclusion: Researchers frequently take issue with and sometimes negotiate what is owed to participants and to their communities in exchange for the data they provide. These experiences of moral distress and these improvisations warrant systematic redress, not by individual researchers but by the broader research ethics infrastructure., (© 2023 The Author(s). Published by S. Karger AG, Basel.)
- Published
- 2023
- Full Text
- View/download PDF
47. Targeting Representation: Interpreting Calls for Diversity in Precision Medicine Research.
- Author
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Lee SS, Fullerton SM, McMahon CE, Bentz M, Saperstein A, Jeske M, Vasquez E, Foti N, Saco L, and Shim JK
- Subjects
- Humans, Biomedical Research, Precision Medicine
- Abstract
Scientists have identified a "diversity gap" in genetic samples and health data, which have been drawn predominantly from individuals of European ancestry, as posing an existential threat to the promise of precision medicine. Inadequate inclusion as articulated by scientists, policymakers, and ethicists has prompted large-scale initiatives aimed at recruiting populations historically underrepresented in biomedical research. Despite explicit calls to increase diversity, the meaning of diversity - which dimensions matter for what outcomes and why - remain strikingly imprecise. Drawing on our document review and qualitative data from observations and interviews of funders and research teams involved in five precision medicine research (PMR) projects, we note that calls for increasing diversity often focus on "representation" as the goal of recruitment. The language of representation is used flexibly to refer to two objectives: achieving sufficient genetic variation across populations and including historically disenfranchised groups in research. We argue that these dual understandings of representation are more than rhetorical slippage, but rather allow for the contemporary collection of samples and data from marginalized populations to stand in as correcting historical exclusion of social groups towards addressing health inequity. We trace the unresolved historical debates over how and to what extent researchers should procure diversity in PMR and how they contributed to ongoing uncertainty about what axes of diversity matter and why. We argue that ambiguity in the meaning of representation at the outset of a study contributes to a lack of clear conceptualization of diversity downstream throughout subsequent phases of the study., (Copyright ©2022, Yale Journal of Biology and Medicine.)
- Published
- 2022
48. Strategies of inclusion: The tradeoffs of pursuing "baked in" diversity through place-based recruitment.
- Author
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Shim JK, Bentz M, Vasquez E, Jeske M, Saperstein A, Fullerton SM, Foti N, McMahon C, and Lee SS
- Subjects
- Humans, Residence Characteristics, Biomedical Research, Research Personnel
- Abstract
US funding agencies have begun to institutionalize expectations that biomedical studies achieve defined thresholds for diversity among research participants, including in precision medicine research (PMR). In this paper, we examine how practices of recruitment have unfolded in the wake of these diversity mandates. We find that a very common approach to seeking diverse participants leverages understandings of spatial, geographic, and site diversity as proxies and access points for participant diversity. That is, PMR investigators recruit from a diverse sampling of geographic areas, neighborhoods, sites, and institutional settings as both opportunistic but also meaningful ways to "bake in" participant diversity. In this way, logics of geographic and institutional diversity shift the question from who to recruit, to where. However, despite seeing geographic and site diversity as social and scientific 'goods' in the abstract and as key to getting diverse participants, PMR teams told us that working with diverse sites was often difficult in practice due to constraints in funding, time, and personnel, and inadequate research infrastructures and capacity. Thus, the ways in which these geographic and institutional diversity strategies were implemented resulted ultimately in limiting the meaningful inclusion of populations and organizations that had not previously participated in biomedical research and reproduced the inclusion of institutions that are already represented. These prevailing assumptions about and practices of "baked-in" diversity in fact exacerbate and produce other forms of inequity, in research capacity and research representation. These findings underscore how structural inequities in research resources must be addressed for diversity to be achieved in both research sites and research participants., (Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2022
- Full Text
- View/download PDF
49. Neural Granger Causality.
- Author
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Tank A, Covert I, Foti N, Shojaie A, and Fox EB
- Subjects
- Humans, Linear Models, Algorithms, Neural Networks, Computer
- Abstract
While most classical approaches to Granger causality detection assume linear dynamics, many interactions in real-world applications, like neuroscience and genomics, are inherently nonlinear. In these cases, using linear models may lead to inconsistent estimation of Granger causal interactions. We propose a class of nonlinear methods by applying structured multilayer perceptrons (MLPs) or recurrent neural networks (RNNs) combined with sparsity-inducing penalties on the weights. By encouraging specific sets of weights to be zero-in particular, through the use of convex group-lasso penalties-we can extract the Granger causal structure. To further contrast with traditional approaches, our framework naturally enables us to efficiently capture long-range dependencies between series either via our RNNs or through an automatic lag selection in the MLP. We show that our neural Granger causality methods outperform state-of-the-art nonlinear Granger causality methods on the DREAM3 challenge data. This data consists of nonlinear gene expression and regulation time courses with only a limited number of time points. The successes we show in this challenging dataset provide a powerful example of how deep learning can be useful in cases that go beyond prediction on large datasets. We likewise illustrate our methods in detecting nonlinear interactions in a human motion capture dataset.
- Published
- 2022
- Full Text
- View/download PDF
50. Beyond inclusion: Enacting team equity in precision medicine research.
- Author
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Jeske M, Vasquez E, Fullerton SM, Saperstein A, Bentz M, Foti N, Shim JK, and Lee SS
- Subjects
- Adolescent, Adult, Aged, Female, Genomics ethics, Health Workforce ethics, Humans, Laboratory Personnel organization & administration, Male, Middle Aged, Patient Care Team ethics, Patient Care Team organization & administration, United States, Young Adult, Biomedical Research ethics, Cultural Diversity, Laboratory Personnel ethics, Precision Medicine ethics
- Abstract
Purpose: To identify meanings of and challenges to enacting equitable diversification of genomics research, and specifically precision medicine research (PMR), teams., Methods: We conducted in-depth interviews with 102 individuals involved in three U.S.-based precision medicine research consortia and conducted over 400 observation hours of their working group meetings, consortium-wide meetings, and conference presentations. We also reviewed published reports on genomic workforce diversity (WFD), particularly those relevant to the PMR community., Results: Our study finds that many PMR teams encounter challenges as they strive to achieve equitable diversification on scientific teams. Interviewees articulated that underrepresented team members were often hired to increase the study's capacity to recruit diverse research participants, but are limited to on-the-ground staff positions with little influence over study design. We find existing hierarchies and power structures in the academic research ecosystem compound challenges for equitable diversification., Conclusion: Our results suggest that meaningful diversification of PMR teams will only be possible when team equity is prioritized as a core value in academic research communities., Competing Interests: The authors have declared that no competing interests exist.
- Published
- 2022
- Full Text
- View/download PDF
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