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5 results on '"Foti, Alexia"'

1. The effect of azithromycin on structural lung disease in infants with cystic fibrosis (COMBAT CF): a phase 3, randomised, double-blind, placebo-controlled clinical trial

Author

Stick, Stephen M, Foti, Alexia, Ware, Robert S, Tiddens, Harm A W M, Clements, Barry S, Armstrong, David S, Selvadurai, Hiran, Tai, Andrew, Cooper, Peter J, Byrnes, Catherine A, Belessis, Yvonne, Wainwright, Claire, Jaffe, Adam, Robinson, Philip, Saiman, Lisa, and Sly, Peter D

Published
2022
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2. The effect of inhaled hypertonic saline on lung structure in children aged 3–6 years with cystic fibrosis (SHIP-CT): a multicentre, randomised, double-blind, controlled trial

Author

Andrinopoulou, Eleni-Rosalina, Anthony, Margaret M., Au, Jacky, Belessis, Yvonne, Bonte, Merlijn, Chen, Yuxin, Cheney, Joyce, Clem, Charles, Clements, Barry, Cooper, Peter, Dasiewicz, Alison, Davis, Stephanie D., Davis, Miriam, de Boeck, Kris, de Marchis, Matteo, De Wachter, Elke, Delaisi, Bertrand, Delaup, Véronique, DeRicco, Adrienne, Foti, Alexia, Gan, Richard, Garriga, Laura, Gartner, Silvia, Genatossio, Alan, Grogan, Sam, Hilton, Jodi, Hinckley Stukovsky, Karen D, Hoppe, Jordana E., Janssens, Hettie M., Jensen, Renee, Johnson, Robin, Kemner-van de Corput, Mariette P.C., Klein, Brendan, Kronmal, Richard A., Lucca, Francesca, Lucidi, Vincencina, Montemitro, Enza, Nahidi, Lily, Nielsen, Kim G., Pearce, Kasey, Pittman, Jessica E, Powers, Michael, Prentice, Carley, Pressler, Tania, Ratjen, Felix, Rayment, Jonathan H, Reix, Philippe, Retsch-Bogart, George, Riera, Luis, Robinson, Phil, Robinson, Paul, Rosenfeld, Margaret, Sanders, Don B., Sandoval, Rodrigo A., Sandvik, Rikke Mulvad, Saunders, Clare, Siegel, Molly, Smith, Julie, Solomon, Melinda, Stanojevic, Sanja, Stick, Stephen Michael, Tai, Andrew, Tiddens, Harm A.W.M., van de Puttelaar, Jorien, Van den Brande, Christel, van Straten, Marcel, Vermeulen, Francois, Volpi, Sonia, Wainwright, Claire E., Weiner, Daniel J., Yuan, Yi, Zaimeddine, Sarah, Tiddens, Harm A W M, Davis, Stephanie D, and Kronmal, Richard A

Published
2022
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3. The effect of inhaled hypertonic saline on lung structure in children aged 3–6 years with cystic fibrosis (SHIP-CT): a multicentre, randomised, double-blind, controlled trial

Author

Tiddens, Harm A W M, primary, Chen, Yuxin, additional, Andrinopoulou, Eleni-Rosalina, additional, Davis, Stephanie D, additional, Rosenfeld, Margaret, additional, Ratjen, Felix, additional, Kronmal, Richard A, additional, Hinckley Stukovsky, Karen D, additional, Dasiewicz, Alison, additional, Stick, Stephen Michael, additional, Anthony, Margaret M., additional, Au, Jacky, additional, Belessis, Yvonne, additional, Bonte, Merlijn, additional, Cheney, Joyce, additional, Clem, Charles, additional, Clements, Barry, additional, Cooper, Peter, additional, Davis, Stephanie D., additional, Davis, Miriam, additional, de Boeck, Kris, additional, de Marchis, Matteo, additional, De Wachter, Elke, additional, Delaisi, Bertrand, additional, Delaup, Véronique, additional, DeRicco, Adrienne, additional, Foti, Alexia, additional, Gan, Richard, additional, Garriga, Laura, additional, Gartner, Silvia, additional, Genatossio, Alan, additional, Grogan, Sam, additional, Hilton, Jodi, additional, Hoppe, Jordana E., additional, Janssens, Hettie M., additional, Jensen, Renee, additional, Johnson, Robin, additional, Kemner-van de Corput, Mariette P.C., additional, Klein, Brendan, additional, Kronmal, Richard A., additional, Lucca, Francesca, additional, Lucidi, Vincencina, additional, Montemitro, Enza, additional, Nahidi, Lily, additional, Nielsen, Kim G., additional, Pearce, Kasey, additional, Pittman, Jessica E, additional, Powers, Michael, additional, Prentice, Carley, additional, Pressler, Tania, additional, Rayment, Jonathan H, additional, Reix, Philippe, additional, Retsch-Bogart, George, additional, Riera, Luis, additional, Robinson, Phil, additional, Robinson, Paul, additional, Sanders, Don B., additional, Sandoval, Rodrigo A., additional, Sandvik, Rikke Mulvad, additional, Saunders, Clare, additional, Siegel, Molly, additional, Smith, Julie, additional, Solomon, Melinda, additional, Stanojevic, Sanja, additional, Tai, Andrew, additional, Tiddens, Harm A.W.M., additional, van de Puttelaar, Jorien, additional, Van den Brande, Christel, additional, van Straten, Marcel, additional, Vermeulen, Francois, additional, Volpi, Sonia, additional, Wainwright, Claire E., additional, Weiner, Daniel J., additional, Yuan, Yi, additional, and Zaimeddine, Sarah, additional

Published
2022
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4. The effect of azithromycin on structural lung disease in infants with cystic fibrosis (COMBAT CF):a phase 3, randomised, double-blind, placebo-controlled clinical trial

Author

Stick, Stephen M., Foti, Alexia, Ware, Robert S., Tiddens, Harm A.W.M., Clements, Barry S., Armstrong, David S., Selvadurai, Hiran, Tai, Andrew, Cooper, Peter J., Byrnes, Catherine A., Belessis, Yvonne, Wainwright, Claire, Jaffe, Adam, Robinson, Philip, Saiman, Lisa, Sly, Peter D., Stick, Stephen M., Foti, Alexia, Ware, Robert S., Tiddens, Harm A.W.M., Clements, Barry S., Armstrong, David S., Selvadurai, Hiran, Tai, Andrew, Cooper, Peter J., Byrnes, Catherine A., Belessis, Yvonne, Wainwright, Claire, Jaffe, Adam, Robinson, Philip, Saiman, Lisa, and Sly, Peter D.

Abstract

Background: Structural lung disease and neutrophil-dominated airway inflammation is present from 3 months of age in children diagnosed with cystic fibrosis after newborn screening. We hypothesised that azithromycin, given three times weekly to infants with cystic fibrosis from diagnosis until age 36 months, would reduce the extent of structural lung disease as captured on chest CT scans. Methods: A phase three, randomised, double-blind, placebo-controlled trial was done at eight paediatric cystic fibrosis centres in Australia and New Zealand. Infants (aged 3–6 months) diagnosed with cystic fibrosis following newborn screening were eligible. Exclusion criteria included prolonged mechanical ventilation in the first 3 months of life, clinically significant medical disease or comorbidities other than cystic fibrosis, or macrolide hypersensitivity. Participants were randomly assigned (1:1) to receive either azithromycin (10 mg/kg bodyweight orally three times per week) or matched placebo until age 36 months. Randomisation was done with a permuted block strategy and an interactive web-based response system, stratified by study site. Unblinding was done once all participants completed the trial. The two primary outcomes were the proportion of children with radiologically defined bronchiectasis, and the percentage of total lung volume affected by disease. Secondary outcomes included clinical outcomes and exploratory outcomes were inflammatory markers. Analyses were done with the intention-to-treat principle. This study is registered at ClinicalTrials.gov (NCT01270074). Findings: Between June 15, 2012, and July 10, 2017, 281 patients were screened, of whom 130 were enrolled, randomly assigned, and received first study dose. 68 participants received azithromycin and 62 received placebo. At 36 months, 88% (n=50) of the azithromycin group and 94% (n=44) of the placebo group had bronchiectasis (odds ratio 0·49, 95% CI 0·12 to 2·00; p=0·32), and total airways disease did not d

Published
2022

5. The Effect of Azithromycin on Structural Lung Disease in Infants with Cystic Fibrosis (COMBAT CF): A Phase 3, Randomised, Double-Blind, Placebo-Controlled Clinical Trial

Author

Stick, Stephen M., primary, Foti, Alexia, additional, Ware, Robert S., additional, Tiddens, Harm A. W. M., additional, Clements, Barry S., additional, Armstrong, David S., additional, Selvadurai, Hiran, additional, Tai, Andrew, additional, Cooper, Peter J., additional, Byrnes, Catherine A., additional, Belessis, Yvonne, additional, Wainwright, Claire, additional, Jaffe, Adam, additional, Robinson, Philip, additional, Saiman, Lisa, additional, and Sly, Peter D., additional

Published
2021
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