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31 results on '"Foss, Amelia"'

1. Abstract B035: A compendium of syngeneic, transplantable pediatric high-grade glioma models reveals subtype-specific therapeutic vulnerabilities

Author

McNicholas, Michael, primary, De Cola, Antonella, additional, Bashardanesh, Zahedeh, additional, Foss, Amelia, additional, Lloyd, Cameron, additional, Hebert, Steven, additional, Faury, Damien, additional, Andrade, Augusto Faria, additional, Jabado, Nada, additional, Kleinman, Claudia, additional, and Pathania, Manav, additional

Published
2024
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2. Figure 6 from A Compendium of Syngeneic, Transplantable Pediatric High-Grade Glioma Models Reveals Subtype-Specific Therapeutic Vulnerabilities

Author

McNicholas, Michael, primary, De Cola, Antonella, primary, Bashardanesh, Zahedeh, primary, Foss, Amelia, primary, Lloyd, Cameron B., primary, Hébert, Steven, primary, Faury, Damien, primary, Andrade, Augusto Faria, primary, Jabado, Nada, primary, Kleinman, Claudia L., primary, and Pathania, Manav, primary

Published
2024
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3. Supplementary Table 6 from A Compendium of Syngeneic, Transplantable Pediatric High-Grade Glioma Models Reveals Subtype-Specific Therapeutic Vulnerabilities

Author

McNicholas, Michael, primary, De Cola, Antonella, primary, Bashardanesh, Zahedeh, primary, Foss, Amelia, primary, Lloyd, Cameron B., primary, Hébert, Steven, primary, Faury, Damien, primary, Andrade, Augusto Faria, primary, Jabado, Nada, primary, Kleinman, Claudia L., primary, and Pathania, Manav, primary

Published
2024
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4. Data from A Compendium of Syngeneic, Transplantable Pediatric High-Grade Glioma Models Reveals Subtype-Specific Therapeutic Vulnerabilities

Author

McNicholas, Michael, primary, De Cola, Antonella, primary, Bashardanesh, Zahedeh, primary, Foss, Amelia, primary, Lloyd, Cameron B., primary, Hébert, Steven, primary, Faury, Damien, primary, Andrade, Augusto Faria, primary, Jabado, Nada, primary, Kleinman, Claudia L., primary, and Pathania, Manav, primary

Published
2024
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5. Supplementary Table 5 from A Compendium of Syngeneic, Transplantable Pediatric High-Grade Glioma Models Reveals Subtype-Specific Therapeutic Vulnerabilities

Author

McNicholas, Michael, primary, De Cola, Antonella, primary, Bashardanesh, Zahedeh, primary, Foss, Amelia, primary, Lloyd, Cameron B., primary, Hébert, Steven, primary, Faury, Damien, primary, Andrade, Augusto Faria, primary, Jabado, Nada, primary, Kleinman, Claudia L., primary, and Pathania, Manav, primary

Published
2024
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6. Supplementary Tables 1-3, 7-9 from A Compendium of Syngeneic, Transplantable Pediatric High-Grade Glioma Models Reveals Subtype-Specific Therapeutic Vulnerabilities

Author

McNicholas, Michael, primary, De Cola, Antonella, primary, Bashardanesh, Zahedeh, primary, Foss, Amelia, primary, Lloyd, Cameron B., primary, Hébert, Steven, primary, Faury, Damien, primary, Andrade, Augusto Faria, primary, Jabado, Nada, primary, Kleinman, Claudia L., primary, and Pathania, Manav, primary

Published
2024
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7. Supplementary Table 4 from A Compendium of Syngeneic, Transplantable Pediatric High-Grade Glioma Models Reveals Subtype-Specific Therapeutic Vulnerabilities

Author

McNicholas, Michael, primary, De Cola, Antonella, primary, Bashardanesh, Zahedeh, primary, Foss, Amelia, primary, Lloyd, Cameron B., primary, Hébert, Steven, primary, Faury, Damien, primary, Andrade, Augusto Faria, primary, Jabado, Nada, primary, Kleinman, Claudia L., primary, and Pathania, Manav, primary

Published
2024
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8. Supplementary Figures 1-27 from A Compendium of Syngeneic, Transplantable Pediatric High-Grade Glioma Models Reveals Subtype-Specific Therapeutic Vulnerabilities

Author

McNicholas, Michael, primary, De Cola, Antonella, primary, Bashardanesh, Zahedeh, primary, Foss, Amelia, primary, Lloyd, Cameron B., primary, Hébert, Steven, primary, Faury, Damien, primary, Andrade, Augusto Faria, primary, Jabado, Nada, primary, Kleinman, Claudia L., primary, and Pathania, Manav, primary

Published
2024
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9. IER2-induced senescence drives melanoma invasion through osteopontin

Author

Kyjacova, Lenka, Saup, Rafael, Rönsch, Kerstin, Wallbaum, Sabine, Dukowic-Schulze, Stefanie, Foss, Amelia, Scherer, Sandra D., Rothley, Melanie, Neeb, Antje, Grau, Nicole, Thiele, Wilko, Thaler, Sonja, Cremers, Natascha, Sticht, Carsten, Gretz, Norbert, Garvalov, Boyan K., Utikal, Jochen, and Sleeman, Jonathan P.

Published
2021
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11. Supplementary Figures 1-27 from A Compendium of Syngeneic, Transplantable Pediatric High-Grade Glioma Models Reveals Subtype-Specific Therapeutic Vulnerabilities

Author

McNicholas, Michael, primary, De Cola, Antonella, primary, Bashardanesh, Zahedeh, primary, Foss, Amelia, primary, Lloyd, Cameron B., primary, Hébert, Steven, primary, Faury, Damien, primary, Andrade, Augusto Faria, primary, Jabado, Nada, primary, Kleinman, Claudia L., primary, and Pathania, Manav, primary

Published
2023
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12. Supplementary Tables 1-3, 7-9 from A Compendium of Syngeneic, Transplantable Pediatric High-Grade Glioma Models Reveals Subtype-Specific Therapeutic Vulnerabilities

Author

McNicholas, Michael, primary, De Cola, Antonella, primary, Bashardanesh, Zahedeh, primary, Foss, Amelia, primary, Lloyd, Cameron B., primary, Hébert, Steven, primary, Faury, Damien, primary, Andrade, Augusto Faria, primary, Jabado, Nada, primary, Kleinman, Claudia L., primary, and Pathania, Manav, primary

Published
2023
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13. Figure 6 from A Compendium of Syngeneic, Transplantable Pediatric High-Grade Glioma Models Reveals Subtype-Specific Therapeutic Vulnerabilities

Author

McNicholas, Michael, primary, De Cola, Antonella, primary, Bashardanesh, Zahedeh, primary, Foss, Amelia, primary, Lloyd, Cameron B., primary, Hébert, Steven, primary, Faury, Damien, primary, Andrade, Augusto Faria, primary, Jabado, Nada, primary, Kleinman, Claudia L., primary, and Pathania, Manav, primary

Published
2023
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14. Data from A Compendium of Syngeneic, Transplantable Pediatric High-Grade Glioma Models Reveals Subtype-Specific Therapeutic Vulnerabilities

Author

McNicholas, Michael, primary, De Cola, Antonella, primary, Bashardanesh, Zahedeh, primary, Foss, Amelia, primary, Lloyd, Cameron B., primary, Hébert, Steven, primary, Faury, Damien, primary, Andrade, Augusto Faria, primary, Jabado, Nada, primary, Kleinman, Claudia L., primary, and Pathania, Manav, primary

Published
2023
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15. MODL-08. A COMPENDIUM OF SYNGENEIC, TRANSPLANTABLE PEDIATRIC HIGH-GRADE GLIOMA MODELS REVEALS SUBTYPE-SPECIFIC THERAPEUTIC VULNERABILITIES

Author

McNicholas, Michael, primary, De Cola, Antonella, additional, Bashardanesh, Zahedeh, additional, Foss, Amelia, additional, Lloyd, Cameron, additional, Hebert, Steven, additional, Faury, Damien, additional, Andrade, Augusto Faria, additional, Jabado, Nada, additional, Kleinman, Claudia, additional, and Pathania, Manav, additional

Published
2023
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16. A Compendium of Syngeneic, Transplantable Pediatric High-Grade Glioma Models Reveals Subtype-Specific Therapeutic Vulnerabilities

Author

McNicholas, Michael, De Cola, Antonella, Bashardanesh, Zahedeh, Foss, Amelia, Lloyd, Cameron B, Hébert, Steven, Faury, Damien, Andrade, Augusto Faria, Jabado, Nada, Kleinman, Claudia L, Pathania, Manav, McNicholas, Michael [0000-0002-6920-9924], De Cola, Antonella [0000-0002-3202-5339], Bashardanesh, Zahedeh [0000-0003-1277-2270], Foss, Amelia [0000-0001-5956-6779], Lloyd, Cameron B [0000-0003-1055-2282], Hébert, Steven [0000-0001-6267-8595], Faury, Damien [0000-0003-1584-599X], Andrade, Augusto Faria [0000-0001-5866-0501], Jabado, Nada [0000-0003-2485-3692], Kleinman, Claudia L [0000-0002-5158-7126], Pathania, Manav [0000-0001-5635-5028], and Apollo - University of Cambridge Repository

Subjects
Histones, Gene Expression Regulation, Neoplastic, Mice, Oncology, Brain Neoplasms, Mutation, Animals, Brain, Glioma
Abstract

UNLABELLED: Pediatric high-grade gliomas (pHGG) are lethal, incurable brain tumors frequently driven by clonal mutations in histone genes. They often harbor a range of additional genetic alterations that correlate with different ages, anatomic locations, and tumor subtypes. We developed models representing 16 pHGG subtypes driven by different combinations of alterations targeted to specific brain regions. Tumors developed with varying latencies and cell lines derived from these models engrafted in syngeneic, immunocompetent mice with high penetrance. Targeted drug screening revealed unexpected selective vulnerabilities-H3.3G34R/PDGFRAC235Y to FGFR inhibition, H3.3K27M/PDGFRAWT to PDGFRA inhibition, and H3.3K27M/PDGFRAWT and H3.3K27M/PPM1DΔC/PIK3CAE545K to combined inhibition of MEK and PIK3CA. Moreover, H3.3K27M tumors with PIK3CA, NF1, and FGFR1 mutations were more invasive and harbored distinct additional phenotypes, such as exophytic spread, cranial nerve invasion, and spinal dissemination. Collectively, these models reveal that different partner alterations produce distinct effects on pHGG cellular composition, latency, invasiveness, and treatment sensitivity. SIGNIFICANCE: Histone-mutant pediatric gliomas are a highly heterogeneous tumor entity. Different histone mutations correlate with different ages of onset, survival outcomes, brain regions, and partner alterations. We have developed models of histone-mutant gliomas that reflect this anatomic and genetic heterogeneity and provide evidence of subtype-specific biology and therapeutic targeting. See related commentary by Lubanszky and Hawkins, p. 1516. This article is highlighted in the In This Issue feature, p. 1501.

Published
2023
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17. Supplementary Table 6 from A Compendium of Syngeneic, Transplantable Pediatric High-Grade Glioma Models Reveals Subtype-Specific Therapeutic Vulnerabilities

Author

McNicholas, Michael, primary, De Cola, Antonella, primary, Bashardanesh, Zahedeh, primary, Foss, Amelia, primary, Lloyd, Cameron B., primary, Hébert, Steven, primary, Faury, Damien, primary, Andrade, Augusto Faria, primary, Jabado, Nada, primary, Kleinman, Claudia L., primary, and Pathania, Manav, primary

Published
2023
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18. Supplementary Table 4 from A Compendium of Syngeneic, Transplantable Pediatric High-Grade Glioma Models Reveals Subtype-Specific Therapeutic Vulnerabilities

Author

McNicholas, Michael, primary, De Cola, Antonella, primary, Bashardanesh, Zahedeh, primary, Foss, Amelia, primary, Lloyd, Cameron B., primary, Hébert, Steven, primary, Faury, Damien, primary, Andrade, Augusto Faria, primary, Jabado, Nada, primary, Kleinman, Claudia L., primary, and Pathania, Manav, primary

Published
2023
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19. Supplementary Table 5 from A Compendium of Syngeneic, Transplantable Pediatric High-Grade Glioma Models Reveals Subtype-Specific Therapeutic Vulnerabilities

Author

McNicholas, Michael, primary, De Cola, Antonella, primary, Bashardanesh, Zahedeh, primary, Foss, Amelia, primary, Lloyd, Cameron B., primary, Hébert, Steven, primary, Faury, Damien, primary, Andrade, Augusto Faria, primary, Jabado, Nada, primary, Kleinman, Claudia L., primary, and Pathania, Manav, primary

Published
2023
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20. Pediatric Glioma Models Provide Insights into Tumor Development and Future Therapeutic Strategies.

Author

Foss, Amelia and Pathania, Manav

Abstract

In depth study of pediatric gliomas has been hampered due to difficulties in accessing patient tissue and a lack of clinically representative tumor models. Over the last decade, however, profiling of carefully curated cohorts of pediatric tumors has identified genetic drivers that molecularly segregate pediatric gliomas from adult gliomas. This information has inspired the development of a new set of powerful in vitro and in vivo tumor models that can aid in identifying pediatric-specific oncogenic mechanisms and tumor microenvironment interactions. Single-cell analyses of both human tumors and these newly developed models have revealed that pediatric gliomas arise from spatiotemporally discrete neural progenitor populations in which developmental programs have become dysregulated. Pediatric high-grade gliomas also harbor distinct sets of co-segregating genetic and epigenetic alterations, often accompanied by unique features within the tumor microenvironment. The development of these novel tools and data resources has led to insights into the biology and heterogeneity of these tumors, including identification of distinctive sets of driver mutations, developmentally restricted cells of origin, recognizable patterns of tumor progression, characteristic immune environments, and tumor hijacking of normal microenvironmental and neural programs. As concerted efforts have broadened our understanding of these tumors, new therapeutic vulnerabilities have been identified, and for the first time, promising new strategies are being evaluated in the preclinical and clinical settings. Even so, dedicated and sustained collaborative efforts are necessary to refine our knowledge and bring these new strategies into general clinical use. In this review, we will discuss the range of currently available glioma models, the way in which they have each contributed to recent developments in the field, their benefits and drawbacks for addressing specific research questions, and their future utility in advancing biological understanding and treatment of pediatric glioma. [ABSTRACT FROM AUTHOR]

Published
2024
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30. Letter: Amelia R. Foss to John Franklin Goucher, circa January 29, 1910

Author

Foss, Amelia R. (Amelia Robertson), 1840-1926 and Foss, Amelia R. (Amelia Robertson), 1840-1926

Abstract

Letter dated January 29, most likely written in 1910, from Amelia R. Foss, wife of Cyrus D. Foss, bishop of the Methodist Episcopal Church, to John Franklin Goucher, explaining difficulties with the brief biographical sketch of her husband prepared by Dr. North to be printed in connection with Foss' funeral and asking Goucher to add a paragraph or two that would bring out her husband's work as bishop and as a family man. See item gojg329 for a draft of what is believed to be Goucher's contribution to the eulogy for Bishop Cyrus David Foss. (Editor's note: Bishop Foss' funeral service took place on February 1, 1910, thus it is thought this letter was sent in desperation on January 29, 1910, hoping that Goucher could add a few paragraphs to the address prepared by Dr. North in time for the service. Dr. North's address as printed in the Northwestern Christian Advocate for February 16, 1910 does not appear to have included Goucher's paragraphs.)

Published
1910

31. Letter: Amelia R. Foss to John Franklin Goucher, June 17-20, 1907

Author

Foss, Amelia R. (Amelia Robertson), 1840-1926 and Foss, Amelia R. (Amelia Robertson), 1840-1926

Abstract

Letter written between June 17 and June 20, 1907 from Amelia R. Foss, wife of Methodist Episcopal Bishop Cyrus D. Foss, on board the S. S. Korea to John Franklin Goucher, telling him of their trip, especially of her husband's sudden illness, and of their plans to return east as soon as they land in San Francisco, California.

Published
1907

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