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12 results on '"Forte, G. B."'

1. Treatment

Author

Goodwin, C. S., Worsley, B., Pillai, E., Willems, V., Janisch, H. D., Langmaack, H., Sanchez, P., Alcalde, M., Lancho, A., Carpintero, P., Garcia, R., Pajares, J. M., Grigoriev, P. Ya., Isakov, V. A., Iakovenko, E. P., Iakovenko, A. V., Vogt, K., Hahn, H., Rehmann, I. H., Hedding-Eckerich, M., Blessing, J., Sobala, G. M., Lynch, D. A. F., Gallacher, B., Dixon, M. F., Axon, A. T. R., Bayerdörffer, E., Mannes, G., Sommer, A., Höchter, W., Weingart, J., Hatz, R., Miehlke, S., Lehn, N., Ruckdeschel, G., Dirschedl, P., Stolte, M., Adamek, R. J., Wegener, M., Birkholz, S., Opferkuch, W., Rühl, G. H., Wedmann, B., Labenz, J., Gyenes, E., R’hl, G. H., Börsch, G., Maieron, R., Rizzi, C., Zoratti, L., Andreoli, S., Da Broi, G. L., Beltrami, C. A., Chengyl, Zhuya, Yangiong, Mou, Jiesong, Hua, Zhenhua, Zhang, Bierti, L., Bolis, E. G., Di Battista, R., de Franchis, R., McAvinchey, D. J., Laurence, M., O’Riordan, J., Fantazi, M., Khawaja, M., Bologna, E, Stroppiana, M., Peyre, S., Pulitano’, R., Sategna-Guidetti, C., Martin, E., Alarcön, T., Sanz, J. C., Jimonez, M. I., López-Brea, M., Burette, A., Glupczynski, Y., Deprez, C., Di Mario, F., Ferrana, M., Battaglia, G., Dotto, P., Vianello, F., Grasso, G. A., Fiocca, R., Villiani, L., Luinetti, O., Gianatti, A., Boldorini, R., Lazzaroni, M., Bianchi Porro, G., Trespi, E., Perego, M., Alvisi, C., Cesana, B., Solcia, E., Logan, R. P. H., Greaves, R. R., Gummett, P. A., Walker, M. M., Karim, Q. N., Duggan, A. E., Baron, J. H., Misiewicz, J. J., Lohmarm, J., Porst, L. H. H., Schönlebe, J., Riedel, H., Catalano, F., Rizzo, G., Ayoubi Khajekini, M. T., Branciforte, G., Inserra, G., Liberti, A., Suriani, R., Pallante, C., Ravizza, M., Mazzucco, D., Galliano, D., Malandrino, M., Oneglio, R., Colozza, M., Gaia, E., Sallio, F., Colozza, D., Grandis, C., Forte, G. B., Bottiglieri, M. E., Durasco, R., Grimaldi, E., Rocco, P., Xia, H. X., Daw, M. A., Sant, S., Beattie, S., Keane, C. T., O’Morain, C. A., Larsson, H., Berglund, M. L., Tessaro, P., Schiavon, R., Contini, M. G., Ton, T., Norberto, L., Cassaro, M., Rugge, M., Guido, M., Baffa, R., Gloriosa, S., Turatello, F., Naccarato, R., Collins, R., O’Moram, C., Kemmer, T. P., Dominguez-Munoz, J. E., Klingel, H., Malfertheiner, P., McCarthy, C. J., McDermott, M., Hourihane, D., O’Morain, C., Droy-Lefiax, M. T., Forestier, B., Guillomain, D., Plique, O., Brugmann, D., Mégraud, F., Lamouliatte, H., Bernard, P. H., Cayla, R., Mégraud, M., de Mascarel, A., Quintonl, A., McLaren, A., McDowell, S. R., McColm, A. A., O’Malley, C., Bagshaw, J., Bouffant, F., Marelli, P., Cellini, L., Campa, M., Dainelli, B., Soldani, G., del Tacca, M., Ferrini, G., Larcinese, G., Semperlotti, N., Molnar, Gy., Fzentmihalyi, A., Takats, A., Gero, G., Penyige, J., Mark, Gy., Martínez-Gómez, J., García-Novo, D., Acuña-Quinõs, D., Gimeno, M., Vigneri, S., Termini, R., Scialabba, A., Pisciotta, G., Gusmaroli, R., Milesi, F., Mule, P., Menegatti, M., Reale, C., Holten, J., and Vaira, D.

Published
1992
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2. Surgical management of acute pancreatitis in Italy: lessons from a prospective multicentre study

Author

De Rai, Paolo, Zerbi, Alessandro, Castoldi, Laura, Bassi, Claudio, Frulloni, Luca, Uomo, Generoso, Gabbrielli, Armando, Pezzilli, Raffaele, Cavallini, Giorgio, Di Carlo, Valerio, Agugiaro, S., Turri, L., Bartoli, A., Barberini, F., Cavazzoni, G., Bartolo, F., Della Papa, D., Bassi, N., Massani, M., Benedetti, A., Macarri, G., Piergallini, L., Briani, G., Bartolasi, L., Bugnano, L., Buonanno, G. M., Esposito, C., Cordovana, A., Cavina, E., Seccia, M., Lippolis, P., Musco, B., Barletta, M., Chilovi, E., De Guelfi, A., Chirletti, P., Caronna, R., Scozzafava, S., Cardi, M., Cirino, E., Buffone, A., Colangelo, E., Caracino, V., Cortese, F., Casentini, A., Costamagna, G., Trincali, A., Curzio, M., Clivio, S., Segato, S., D'Alessandro, A., Ambrosiani, V., D'Ambrosio, B., Chiodo, C., Dicillo, M., Reale, L., Grandolfo, A., Fabbrucci, P., Bruscino, A., Mugnaini, P., Ferrarese, S., Ugenti, I., Forte, G. B., Rocco, P., Franzè, A., Bertelè, A., Sereni, G., Friedman, Daniele, Mariani, L., Morelli, F., Gai, V., Antro, C., Garcea, D., Gardini, A., Lucci, E., Giulianotti, P. C., Sbrana, F., Balestracci, T., Giulini, S. M., Pellizzari, A., Ronconi, M., Cimaschi, S., Grassini, M., Lacignola, S., Calandro, L., Mazzitelli, L., Costarella, S. M., Egidio, A., Mello Teggia, P., Stefano, E., Cassini, P., Modica, G., Lupo, F., Giraci, G., Mosca, F., Del Chiaro, M., Mosella, G., Benassai, G., Nanni, M., D'Aristotile, A., Negro, P., Pirazzoli, A., Rabitti, P. G., Romano, C., Gerardi, G., Troianello, B., Russello, D., Di Stefano, A., Avelli, S., Salval, N., Bellini, N., Scalon, P., Staudacher, C., Parolini, D., Strazzabosco, M., Signorelli, S., Tedeschi, U., Testoni, P. A., Masci, E., Mariani, A., Torelli, E., Garcea, M. R., Lombardi, V., Lecconi, L., Valeri, L., Presenti, L., Alessio, F., Ventrucci, M., Virzi, S., Cipolla, A., De Rai, P, Zerbi, A, Castoldi, L, Bassi, C, Frulloni, L, Uomo, G, Gabbrielli, A, Pezzilli, R, Cavallini, G, Di Carlo, V, Proinf, Aisp, and Testoni, PIER ALBERTO

Subjects
Male, Time Factors, Pancreatitis, Alcoholic, medicine.medical_treatment, Acute pancreatitis, Surgery, Aged, Biliary Tract Diseases, Chi-Square Distribution, Cholangiopancreatography, Endoscopic Retrograde, Cholecystectomy, Laparoscopic, Female, Guideline Adherence, Humans, Italy, Pancreatitis, Pancreatitis, Acute Necrotizing, Practice Guidelines as Topic, Prospective Studies, Risk Assessment, Risk Factors, Severity of Illness Index, Treatment Outcome, Cholecystectomy, Jejunostomy, Pancreatectomy, Practice Patterns, Physicians', Hepatology, Gastroenterology, Physician's Practice Patterns, Practice Patterns, surgery, Endoscopic Retrograde, Medicine, Cholangiopancreatography, Laparoscopic, Acute Necrotizing, Alcoholic, Prospective cohort study, health care economics and organizations, acute pancreatitis, Corrigendum, Risk assessment, medicine.medical_specialty, education, Severity of illness, Intensive care medicine, Physicians', business.industry, General surgery, Original Articles, medicine.disease, business
Abstract

OBJECTIVE: This study aimed to evaluate the surgical treatment of acute pancreatitis in Italy and to assess compliance with international guidelines. METHODS: A series of 1173 patients in 56 hospitals were prospectively enrolled and their data analysed. RESULTS: Twenty-nine patients with severe pancreatitis underwent surgical intervention. Necrosectomy was performed in 26 patients, associated with postoperative lavage in 70% of cases. A feeding jejunostomy was added in 37% of cases. Mortality was 21%. Of the patients with mild pancreatitis, 714 patients with a biliary aetiology were evaluated. Prophylactic treatment of relapses was carried out in 212 patients (36%) by cholecystectomy and in 161 using a laparoscopic approach. Preoperative endoscopic retrograde cholangiopancreatography was associated with cholecystectomy in 83 patients (39%). Forty-seven patients (22%) were treated at a second admission, with a median delay of 31 days from the onset of pancreatitis. Eighteen patients with severe pancreatitis underwent cholecystectomy 37.9 days after the first admission. There were no deaths. DISCUSSION: The results indicate poor compliance with published guidelines. In severe pancreatitis, early surgical intervention is frequently performed and enteral feeding is seldom used. Only a small number of patients with mild biliary pancreatitis undergo definitive treatment (i.e. cholecystectomy) within 4 weeks of the onset of pancreatitis.

Published
2010
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3. Diagnostic assessment and outcome of acute pancreatitis in Italy: results of a prospective multicentre study. ProInf-AISP: Progetto informatizzato pancreatite acuta, Associazione Italiana Studio Pancreas, phase II

Author

Uomo, G, Pezzilli, R., Gabbrielli, A., Castoldi, L., Zerbi, A., Frulloni, L., De Rai, P., Cavallini, G., Di Carlo, V., Agugiaro, S., Turri, L., Bartoli, A., Barberini, F., Cavazoni, G., Bartolo, F., Della Papa, D., Bassi, C., Bassi, N., Massani, M., Benedetti, A., Macarri, G., Piergallini, L., Briani, G., Bartolasi, L., Brugnano, L., Buonanno, G. M., Esposito, C., Cardovana, A., Cavina, E., Seccia, M., Lipollis, P., Musco, B., Barletta, M., Chilovi, E., De Guelmi, A., Chirletti, P., Caronna, R., Scozzafava, S., Cardi, M., Cirrino, E., Buffone, A., Colangelo, E., Caracino, V., Cortese, F., Cosentini, A., Costamagna, G., Tringali, A., Curzio, M., Clivio, S., Segato, S., D'Alessandro, A., Ambrosini, V., D'Amborsio, B., Chiodo, C., Dicillo, M., Reale, L., Grandolfo, A., Fabbrucci, P., Bruscino, A., Mugnaini, P., Ferrarese, S., Ugenti, I., Forte, G. B., Rocco, P., Franzè, A., Bertelè, A., Sereni, G., Friedman, Daniele, Mariani, L. M., Murelli, Federica, Gai, V., Antro, C., Garcea, D., Gardini, A., Lucci, E., Giulianotti, P. C., Sbrana, F., Balestracci, T., Giulini, S. M., Pellizzari, A., Ronconi, M., Cimaschi, S., Grassini, M., Lacitignola, S., Caliandro, L., Mazzitelli, R., Costarella, S. M., Egidio, A., Mello Teggia, P., Stefano, E., Cassini, P., Modica, G., Lupo, F., Giraci, G., Mosca, F., Del Chiaro, M., Mosella, G., Benassai, G., Nanni, M., D'Aristotile, A., Negro, P., Pirazzoli, A., Rabitti, P. G., Romano, C., Gerardi, G., Troianello, B., Russello, D., Di Stefano, A., Avelli, S., Salvai, M., Bellini, N., Scalon, P., Staudacher, C., Parolini, D., Strazzabosco, M., Signorelli, S., Tedeschi, U., Testoni, P. A., Masci, E., Mariani, A., Torelli, E., Garcea, M. R., Lombardi, V., Cecconi, L., Valeri, A., Presenti, L., Alessio, F., Ventrucci, M., Virzì, S., and Cipolla, A.

Subjects
Adult, Male, Pancreatic necrosis, Severity of Illness Index, Body Mass Index, Acute Pancreatitis, Clinical outcome, Computed tomography, Diagnosis, Pancreatitis, Prognosis, Ultrasonography, Aged, Aged, 80 and over, Cholangiopancreatography, Endoscopic Retrograde, Creatinine, Female, Humans, Italy, Middle Aged, Prospective Studies, Treatment Outcome, Hepatology, Gastroenterology, Endoscopic Retrograde, 80 and over, treatment, Medicine (all), Cholangiopancreatography, acute pancreatitis, diagnosis
Abstract

Up till now, only one study providing practically complete information on acute pancreatitis in Italy has been published. The aim of this prospective study was to evaluate the clinical characteristics, in terms of diagnostic assessment and outcome, of a large series of patients affected by acute pancreatitis in Italy.The study involved 56 Italian centres, homogeneously distributed throughout the entire national territory. Each participating centre was furnished with an ad hoc software including 530 items along with subsequent collection, tabulation and quality control of the data.One thousand five hundred and forty case report forms of patients affected by acute pancreatitis were collected but 367 of them (24%) were subsequently eliminated from the final analysis. Therefore, 1173 patients (581 females and 592 males) were recruited. Mean age of patients was 62.0+/-18.2 years (95% confidence interval, 60.9-63.0). On the basis of Atlanta classification, 1006 patients (85.8%) were defined as mild and 167 (14.2%) as severe pancreatitis. Biliary forms represented the most frequent aetiological category (813 cases, 69.3%) while alcoholic forms only 6.6% (77 cases); the remaining aetiologies accounted for 7.1% (83 cases) while 200 cases (17.1%) remained without a definite aetiological factor. Complete recovery was achieved in 1016 patients (86.6%) whereas morphological sequelae were found in 121 patients (10.3%) and mortality in 36 patients (3.1%; 0.4% in mild and 19.2% in severe acute pancreatitis). Ultrasonography was largely utilised as a first line diagnostic tool in all patients, with valuable visualisation of the pancreas in 85% of patients. Computer tomography scan was also widely used, with 66.7% of exams in mild and 33.3% in severe pancreatitis. Patients affected by biliary pancreatitis presented more severe (p=0.004) and necrotizing forms (p=0.021). Mortality was significantly related (p0.001) with the extension of pancreatic necrosis and with an age of over 70 years. Body mass index presented significantly greater values in severe than in mild forms (p0.001).Association of creatinine serum level over 2mg/dl with an abnormal chest X-ray showed a high significant correlation with a more severe outcome in terms of morphological sequelae and mortality (p=0.0001). Acute pancreatitis in Italy more commonly presents biliary aetiology and favourable outcome with low rate of complications and mortality. From a cost-effectiveness standpoint, diagnostic approach to this disease needs to be better standardised.

Published
2007

4. A prospective multicentre survey on the treatment of acute pancreatitis in Italy

Author

Pezzilli, R, Uomo, G., Gabbrielli, A., Zerbi, A., Frulloni, L., De Rai, P., Castoldi, L., Cavallini, G., Di Carlo, V., Agugiaro, S., Turri, L., Bartoli, A., Barberini, F., Cavazoni, G., Bartolo, F., Della Papa, D., Bassi, C., Bassi, N., Massani, M., Benedetti, A., Macarri, G., Piergallini, L., Briani, G., Bartolasi, L., Brugnano, L., Buonanno, G. M., Esposito, C., Cardovana, A., Cavina, E., Seccia, M., Lipollis, P., Musco, B., Barletta, M., Chilovi, E., De Guelmi, A., Chirletti, Piero, Caronna, Roberto, Scozzafava, S., Cardi, Maurizio, Cirino, E., Buffone, A., Colangelo, E., Caracino, V., Cortese, F., Cosentini, A., Costamagna, G., Tringali, A., Curzio, M., Clivio, S., Segato, S., D'Alessandro, A., Ambrosini, V., D'Amborsio, B., Chiodo, C., Dicillo, M., Reale, L., Grandolfo, A., Fabbrucci, P., Bruscino, A., Mugnaini, P., Ferrarese, S., Ugenti, I., Forte, G. B., Rocco, P., Franzè, A., Bertelè, A., Sereni, G., Friedman, D., Mariani, L. M., Murelli, F., Gai, V., Antro, C., Garcea, D., Gardini, A., Lucci, E., Giulianotti, P. C., Sbrana, F., Balestracci, T., Giulini, S. M., Pellizzari, A., Ronconi, M., Cimaschi, S., Grassini, M., Lacitignola, S., Caliandro, L., Mazzitelli, R., Costarella, S. M., Egidio, A., Mello Teggia, P., Stefano, E., Cassini, P., Modica, G., Lupo, F., Giraci, G., Mosca, F., Del Chiaro, M., Mosella, G., Benassai, G., Nanni, M., D'Aristotile, A., Negro, P., Pirazzoli, A., Rabitti, P. G., Romano, C., Gerardi, G., Troianello, B., Russello, D., Di Stefano, A., Avelli, S., Salvai, M., Bellini, N., Scalon, P., Staudacher, C., Parolini, D., Strazzabosco, M., Signorelli, S., Tedeschi, U., Testoni, P. A., Masci, E., Mariani, A., Torelli, E., Garcea, M. R., Lombardi, V., Cecconi, L., Valeri, A., Presenti, L., Alessio, F., Ventrucci, M., Virzi, S., and Cipolla, A.

Subjects
Adult, Male, medicine.medical_specialty, ERCP, Pancreatitis, Pancreatitis acute necrotising, Aged, Aged, 80 and over, Analgesics, Anti-Bacterial Agents, Digestive System Surgical Procedures, Female, Histamine Antagonists, Humans, Italy, Middle Aged, Prospective Studies, Severity of Illness Index, Treatment Outcome, Medicine (all), Hepatology, Gastroenterology, Therapeutic approach, Internal medicine, Severity of illness, 80 and over, Medicine, Prospective cohort study, business.industry, medicine.disease, Surgery, medicine.anatomical_structure, Acute pancreatitis, Tramadol, business, Pancreas, medicine.drug
Abstract

The Italian Association for the Study of the Pancreas released a diagnostic and therapeutic algorithm for acute pancreatitis in 1999.This study focused on the analysis of the therapeutic approach for the treatment of acute pancreatitis in Italy.One thousand, one hundred and seventy-three patients were recruited: 1006 patients (85.8%) had mild acute pancreatitis (MAP) and 167 (14.2%) had the severe acute pancreatitis (SAP); 161 patients showed pancreatic necrosis at computed tomography; 121 patients (10.3%) had sequelae and 36 (3.1%) died.Non-steroidal anti-inflammatory drugs and tramadol were used more frequently in patients with the MAP whereas opioids and the association schedules were used more frequently in patients with the SAP (P0.001). Gabexate mesilate was utilised in 831 out of 1173 patients (70.8%); in particular, gabexate mesilate was used in 70.6% patients with MAP and in 73.1% of those with SAP (P=0.521). The duration of the drug administration was significantly shorter in those having MAP than in those having the SAP (P0.001). The antibiotics most frequently used for the prophylaxis against infection from pancreatic necrosis (43.1%) were carbapenems. Only a small number of patients received enteral nutrition (4.7%). Endoscopic retrograde cholangiopancreatography was carried out in 344 of the 1173 patients (29.3%). Surgery was performed in 48 with SAP (19 had elective biliary surgery and 29 had pancreatic surgery).The results of this survey indicate a lack of compliance with the guidelines which regard the indications mainly for interventional endoscopy and surgery.

Published
2007

6. Total parenteral nutrition-related gastroenterological complications

Author

Carmela Loguercio, D. Boggio-Bertinet, Loris Pironi, A. Guglielmi, Carmine Panella, A. Palmo, G.B. Forte, Francesco William Guglielmi, Antonio Francavilla, Alessandro Federico, Silvia Mazzuoli, Manuela Merli, Guglielmi, F. W., BOGGIO BERTINET, D, Federico, Alessandro, Forte, G. B., Guglielmi, A, Loguercio, Carmelina, Mazzuoli, S, Merli, M, Palmo, A, Panella, C, Pironi, L, Francavilla, A., Boggio Bertinet, D., Federico, A., Guglielmi, A., Loguercio, C., Mazzuoli, S., Merli, M., Palmo, A., Panella, C., and Pironi, Lori

Subjects
medicine.medical_specialty, Cirrhosis, BILIARY COMPLICATIONS, Biliary Tract Diseases, Gastroenterology, Enteral administration, Liver disease, Cholestasis, Risk Factors, Internal medicine, medicine, Animals, Humans, Biliary sludge, Hepatology, business.industry, Liver Diseases, Gallstones, medicine.disease, Intestines, GASTROINTESTINAL COMPLICATIONS, Parenteral nutrition, LIVER COMPLICATIONS, PARENTERAL NUTRITION, Parenteral Nutrition, Total, Steatohepatitis, business, colestasis, liver cirrhosis, steatosis, end-stage liver disease, cholelitiasis, total parenteral nutrition, steatohepatitis
Abstract

Total parenteral nutrition is a life saving therapy for patients with chronic gastrointestinal failure, being an effective method for supplying energy and nutrients when oral or enteral feeding is impossible or contraindicated. Clinical epidemiological data indicate that total parenteral nutrition may be associated with a variety of problems. Herein we reviewed data on the gastroenterological tract regarding: (i) total parenteral nutrition-related hepatobiliary complications; and (ii) total parenteral nutrition-related intestinal complications. In the first group, complications may vary from mildly elevated liver enzyme values to steatosis, steatohepatitis, cholestasis, fibrosis and cirrhosis. In particular, total parenteral nutrition is considered to be an absolute risk factor for the development of biliary sludge and gallstones and is often associated with hepatic steatosis and intrahepatic cholestasis. In general, the incidence of total parenteral nutrition-related hepatobiliary complications has been reported to be very high, ranging from 20 to 75% in adults. All these hepatobiliary complications are more likely to occur after long-term total parenteral nutrition, but they seem to be less frequent, and/or less severe in patients who are also receiving oral feeding. In addition, end-stage liver disease has been described in approximately 15-20% of patients receiving prolonged total parenteral nutrition. Total parenteral nutrition-related intestinal complications have not yet been adequately defined and described. Epidemiological studies intended to define the incidence of these complications, are still ongoing. Recent papers confirm that in both animals and humans, total parenteral nutrition-related intestinal complications are induced by the lack of enteral stimulation and are characterised by changes in the structure and function of the gut. Preventive suggestions and therapies for both these gastroenterological complications are reviewed and reported in the present review.

Published
2006

7. Total parenteral nutrition-related gastroenterological complications.

Author

Guglielmi FW, Boggio-Bertinet D, Federico A, Forte GB, Guglielmi A, Loguercio C, Mazzuoli S, Merli M, Palmo A, Panella C, Pironi L, and Francavilla A

Subjects
Animals, Biliary Tract Diseases therapy, Humans, Intestines immunology, Liver Diseases therapy, Risk Factors, Biliary Tract Diseases etiology, Liver Diseases etiology, Parenteral Nutrition, Total adverse effects
Abstract

Total parenteral nutrition is a life saving therapy for patients with chronic gastrointestinal failure, being an effective method for supplying energy and nutrients when oral or enteral feeding is impossible or contraindicated. Clinical epidemiological data indicate that total parenteral nutrition may be associated with a variety of problems. Herein we reviewed data on the gastroenterological tract regarding: (i) total parenteral nutrition-related hepatobiliary complications; and (ii) total parenteral nutrition-related intestinal complications. In the first group, complications may vary from mildly elevated liver enzyme values to steatosis, steatohepatitis, cholestasis, fibrosis and cirrhosis. In particular, total parenteral nutrition is considered to be an absolute risk factor for the development of biliary sludge and gallstones and is often associated with hepatic steatosis and intrahepatic cholestasis. In general, the incidence of total parenteral nutrition-related hepatobiliary complications has been reported to be very high, ranging from 20 to 75% in adults. All these hepatobiliary complications are more likely to occur after long-term total parenteral nutrition, but they seem to be less frequent, and/or less severe in patients who are also receiving oral feeding. In addition, end-stage liver disease has been described in approximately 15-20% of patients receiving prolonged total parenteral nutrition. Total parenteral nutrition-related intestinal complications have not yet been adequately defined and described. Epidemiological studies intended to define the incidence of these complications, are still ongoing. Recent papers confirm that in both animals and humans, total parenteral nutrition-related intestinal complications are induced by the lack of enteral stimulation and are characterised by changes in the structure and function of the gut. Preventive suggestions and therapies for both these gastroenterological complications are reviewed and reported in the present review.

Published
2006
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8. Efficacy of high dose of recombinant alpha 2b interferon on long term response in chronic hepatitis C and cirrhosis: prospective randomized multicentre study.

Author

Ascione A, De Luca M, Canestrini C, Di Costanzo GG, Raimondo G, Longo G, Manns MP, Tillmann HL, Forte GB, Rocco P, Biceglia O, Faleo D, Vinelli F, Cela EM, Amitrano L, Addario L, and Gigliotti T

Subjects
Adult, Aged, Alanine Transaminase blood, Dose-Response Relationship, Drug, Drug Administration Schedule, Female, Follow-Up Studies, Hepatitis C, Chronic complications, Hepatitis C, Chronic virology, Humans, Liver Cirrhosis enzymology, Liver Cirrhosis etiology, Male, Middle Aged, Prospective Studies, RNA, Viral analysis, Recombinant Proteins, Treatment Outcome, Antiviral Agents administration & dosage, Hepatitis C, Chronic drug therapy, Interferon Type I administration & dosage, Liver Cirrhosis drug therapy
Abstract

Background/aims: The long-term response to alpha-Interferon in HCV-related chronic liver diseases is disappointing. A randomized controlled trial was conducted to investigate: 1) if doubling the standard regimen of 3 MU recombinant alpha 2b-interferon thrice weekly for one year could improve the long-term response, and 2) the efficacy of these two schedules in cirrhotic patients., Patients and Methods: A series of 80 anti-HCV positive patients with biopsy proven liver disease (52 chronic hepatitis and 28 cirrhosis) were randomized to receive either 3 MU or 6 MU alpha 2b-interferon., Results: Based on "intention-to-treat analysis", 38% in the 3 MU group and 53% in the 6 MU group had end-of-treatment response. After 24 months, 18% had long-term response: 5% in 3 MU group and 30% in 6 MU group (p < 0.008). HCV genotype had no influence on the response rate. Thirty-eight percent of the cirrhotics treated with 6 MU had long-term response, while none of those treated with 3 MU had long-term response (difference 38%; 95% confidence internal 10%-67%; p = 0.03). At the end of treatment, 38% of patients lost HCV-RNA. After 24 months only 19% remained HCV-RNA negative: 12 patients (31%) in the 6 MU group and 2 (6%) in the 3 MU group (p < 0.05)., Conclusions: 6 MU of alpha 2b-interferon thrice weekly for 12 months is significantly better than 3 MU in inducing a long-term response and permanent loss of HCV-RNA. This result is particularly striking in the subgroup of cirrhotics.

Published
1998

10. [The peripheral blood lymphocyte subpopulations in chronic anti-HCV-positive liver disease: their significance and correlation with liver function].

Author

Rocco P, Biceglia O, Paceli M, Minerva A, De Biasio MC, De Crescenzo OD, and Forte GB

Subjects
Adult, Biopsy, Female, Hepatitis C physiopathology, Hepatitis, Chronic physiopathology, Humans, Lidocaine analogs & derivatives, Liver pathology, Liver Cirrhosis immunology, Liver Cirrhosis physiopathology, Male, Middle Aged, Hepatitis C immunology, Hepatitis, Chronic immunology, Liver physiopathology, Lymphocyte Subsets immunology
Abstract

To evaluate the role played by the immune system in the outcome of chronic C virus infection, we studied the peripheral blood lymphocyte subsets in patients with chronic hepatitis C and the correlation with the hepatic function assessed by the lidocaine test. To this end the peripheral lymphocyte subpopulations were enumerated by flow cytometry in 36 patients we had undergone a liver biopsy, prior the interferon therapy. The patients were classified as having severe chronic hepatitis with or without cirrhosis (17 subjects = group A) and mild/moderate chronic hepatitis without cirrhosis (19 subjects = group B). Twelve patients in group A and 9 in group B underwent the lidocaine test. The mean percentages of the lymphocyte subsets were not different in the two groups and in comparison with a standard healthy population, with the exception of okdr+ lymphocytes; they were significantly increased in group A (p = 0.04). The production of the lidocaine metabolite at 30 minutes prove, significantly decreased in patients with severe hepatic disease (p = 0.02), but there is no correlation between the decline of liver function and the peripheral increase of the okdr+ lymphocytes (r = 0.1877). It is probable that the increase in okdr+ lymphocytes, due to activated T-cells, is subordinated to the persistent viremia but it is independent of histological damage.

Published
1996

11. Prepacked kits for diagnosis and treatment of tuberculosis in former Yugoslavia.

Author

Felten MK and Forte GB

Subjects
Antitubercular Agents, Delivery of Health Care methods, Humans, Sputum microbiology, Yugoslavia, Reagent Kits, Diagnostic, Relief Work, Tuberculosis diagnosis, Tuberculosis drug therapy, Warfare, World Health Organization
Abstract

Setting: After the outbreak of armed conflicts in the republics of former Yugoslavia in 1991, basic health services deteriorated and shortages of essential medical supplies occurred. The World Health Organization (WHO) has taken part in emergency relief operations in the area since July 1992. There was a growing concern that poor living conditions and shortages of supplies could rapidly increase the tuberculosis problem., Objective: To provide essential supplies, WHO included support of tuberculosis control in the emergency relief operations for former Yugoslavia., Design: WHO designed a prepacked kit with anti-tuberculosis drugs and material for sputum smear examination for use in combination with policy recommendations and a treatment protocol., Results: The initial distribution of the kits was completed by the end of April 1994. Medium term support from May 1994 onwards has included continued distribution of kits, together with assistance in adjusting tuberculosis control programmes according to the recommended WHO policy package., Conclusion: Support of tuberculosis control with essential supplies and strictly focusing on priority measures is proposed as the most adequate strategy, when dealing with a developed country dependent on humanitarian assistance.

Published
1995
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12. Serological markers of hepatitis B virus infection in healthy volunteer blood donors in Campania (Southern Italy).

Author

Ascione A, Forte GB, Amitrano L, De Bellis G, Pandolfi C, Iaccarino L, Mariconda M, Petringa D, Utech W, and Vacca C

Subjects
Adolescent, Adult, Hepatitis B Core Antigens immunology, Humans, Italy, Middle Aged, Antibodies, Viral analysis, Blood Donors, Hepatitis B epidemiology, Hepatitis B Antibodies analysis, Hepatitis B Surface Antigens analysis
Abstract

The prevalence of hepatitis B virus (HBV) serological markers was determined in a prospective fashion by radioimmunoassay in 2,084 healthy volunteer blood donors. The results showed that 51.2% of the donors were positive for at least one marker, and the percentage of occurrence of each marker was: HBsAg 5.3, anti-HBs alone 1.7, anti-HBc alone 10.8, anti-HBs and anti-HBc 33.3. Because of the size of the problem this investigation strongly demands further studies on the potential role of blood positive for anti-HBc in transmitting HBV infection in our geographical area.

Published
1981
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