15 results on '"Forsait, Silvana"'
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2. Technical performance of a lateral flow immunoassay for detection of anti-SARS-CoV-2 IgG in the outpatient follow-up of non-severe cases and at different times after vaccination: comparison with enzyme and chemiluminescent immunoassays
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Barreira, Gabriel Acca, Santos, Emilly Henrique dos, Pereira, Maria Fernanda Bádue, Rodrigues, Karen Alessandra, Rocha, Mussya Cisotto, Kanunfre, Kelly Aparecida, Marques, Heloisa Helena de Sousa, Okay, Thelma Suely, Eisencraft, Adriana Pasmanik, Rossi Junior, Alfio, Fante, Alice Lima, Cora, Aline Pivetta, Costa Reis, Amelia Gorete A. de, Ferrer, Ana Paula Scoleze, Andrade, Anarella Penha Meirelles de, Watanabe, Andreia, Gonçalves, Angelina Maria Freire, Waetge, Aurora Rosaria Pagliara, Silva, Camila Altenfelder, Ceneviva, Carina, Lazari, Carolina dos Santos, Abellan, Deipara Monteiro, Sabino, Ester Cerdeira, Bianchini, Fabíola Roberta Marim, Alcantara, Flávio Ferraz de Paes, Ramos, Gabriel Frizzo, Leal, Gabriela Nunes, Rodriguez, Isadora Souza, Pinho, João Renato Rebello, Carneiro, Jorge David Avaizoglou, Paz, Jose Albino, Ferreira, Juliana Carvalho, Ferranti, Juliana Ferreira, Ferreira, Juliana de Oliveira Achili, Framil, Juliana Valéria de Souza, Silva, Katia Regina da, Bastos, Karina Lucio de Medeiros, Galleti, Karine Vusberg, Cristofani, Lilian Maria, Suzuki, Lisa, Campos, Lucia Maria Arruda, Perondi, Maria Beatriz de Moliterno, Diniz, Maria de Fatima Rodrigues, Fonseca, Maria Fernanda Mota, Cordon, Mariana Nutti de Almeida, Pissolato, Mariana, Peres, Marina Silva, Garanito, Marlene Pereira, Imamura, Marta, Dorna, Mayra de Barros, Luglio, Michele, Aikawa, Nadia Emi, Degaspare, Natalia Viu, Sakita, Neusa Keico, Udsen, Nicole Lee, Scudeller, Paula Gobi, Gaiolla, Paula Vieira de Vincenzi, Severini, Rafael da Silva Giannasi, Rodrigues, Regina Maria, Toma, Ricardo Katsuya, Paula, Ricardo Iunis Citrangulo de, Palmeira, Patricia, Forsait, Silvana, Farhat, Sylvia Costa Lima, Sakano, Tânia Miyuki Shimoda, Koch, Vera Hermina Kalika, and Cobello Junior, Vilson
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Adult ,Immunoassay ,Rapid test ,SARS-CoV-2 ,Vaccination ,COVID-19 ,Lateral Flow Immunoassay ,Antibodies, Viral ,Sensitivity and Specificity ,Enzyme Immunoassay ,Immunoglobulin M ,Immunoglobulin G ,Laboratory diagnosis ,Outpatients ,Humans ,Child ,Follow-Up Studies - Abstract
This study assessed the technical performance of a rapid lateral flow immunochromatographic assay (LFIA) for the detection of anti-SARS-CoV-2 IgG and compared LFIA results with chemiluminescent immunoassay (CLIA) results and an in-house enzyme immunoassay (EIA). To this end, a total of 216 whole blood or serum samples from three groups were analyzed: the first group was composed of 68 true negative cases corresponding to blood bank donors, healthy young volunteers, and eight pediatric patients diagnosed with other coronavirus infections. The serum samples from these participants were obtained and stored in a pre-COVID-19 period, thus they were not expected to have COVID-19. In the second group of true positive cases, we chose to replace natural cases of COVID-19 by 96 participants who were expected to have produced anti-SARS-CoV-2 IgG antibodies 30-60 days after the vaccine booster dose. The serum samples were collected on the same day that LFIA were tested either by EIA or CLIA. The third study group was composed of 52 participants (12 adults and 40 children) who did or did not have anti-SARS-CoV-2 IgG antibodies due to specific clinical scenarios. The 12 adults had been vaccinated more than seven months before LFIA testing, and the 40 children had non-severe COVID-19 diagnosed using RT-PCR during the acute phase of infection. They were referred for outpatient follow-up and during this period the serum samples were collected and tested by CLIA and LFIA. All tests were performed by the same healthcare operator and there was no variation of LFIA results when tests were performed on finger prick whole blood or serum samples, so that results were grouped for analysis. LFIA’s sensitivity in detecting anti-SARS-CoV-2 IgG antibodies was 90%, specificity 97.6%, efficiency 93%, PPV 98.3%, NPV 86.6%, and likelihood ratio for a positive or a negative result were 37.5 and 0.01 respectively. There was a good agreement (Kappa index of 0.677) between LFIA results and serological (EIA or CLIA) results. In conclusion, LFIA analyzed in this study showed a good technical performance and agreement with reference serological assays (EIA or CLIA), therefore it can be recommended for use in the outpatient follow-up of non-severe cases of COVID-19 and to assess anti-SARS-CoV-2 IgG antibody production induced by vaccination and the antibodies decrease over time. However, LFIAs should be confirmed by using reference serological assays whenever possible.
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- 2022
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3. O Coração de Pacientes Pediátricos com COVID-19: Novos Insights a Partir de um Estudo Ecocardiográfico Sistemático em um Hospital Terciário no Brasil
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Diniz, Maria de Fátima Rodrigues, Cardoso, Maira Freire, Sawamura, Karen Saori Shiraishi, Menezes, Carolina Rocha Brito, Lianza, Alessandro Cavalcanti, Pereira, Maria Fernanda Badue, Litvinov, Nadia, Ferranti, Juliana Ferreira, Forsait, Silvana, Watanabe, Andreia, Farhat, Sylvia Costa Lima, Aikawa, Nadia Emi, Campos, Lucia Maria Arruda, Delgado, Artur Figueiredo, Carneiro-Sampaio, Magda, Carvalho, Werther Brunow de, Silva, Clovis Artur, and Leal, Gabriela Nunes
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Inflammation ,Heart Failure ,Pandemia ,Insuficiência Cardíaca ,COVID-19 ,Criança ,Echocardiography/methods ,Betacoronavírus ,Inflamação ,Betacoronavirus ,Biomarcadores ,Ecocardiografia/métodos ,Child ,Pandemics ,Biomarkers - Abstract
Resumo Fundamento A pandemia da COVID-19 representa uma enorme carga para o sistema de saúde do mundo. Apesar de pacientes pediátricos terem sido relativamente poupados em comparação a adultos, estudos recentes mostraram um número crescente de pacientes críticos com Síndrome Inflamatória Multisistêmica Pediátrica (SIM-P) com disfunção cardiovascular importante. No entanto, pouco se conhece a respeito da relação entre anormalidades cardíacas e biomarcadores inflamatórios e de coagulação. Objetivos Investigar anormalidades ecocardiográficas em pacientes pediátricos com COVID-19 admitidos em um hospital terciário. Métodos Este foi um estudo longitudinal retrospectivo, baseado na revisão de prontuários médicos e ecocardiogramas de pacientes (0-19 anos) admitidos em um hospital terciário entre 30 de março e 30 de junho de 2020. Para a análise estatística, o nível de significância foi estabelecido em 5% (p+2,5). Anormalidades ecocardiográficas foram significativamente associadas com SIM-P, admissão na unidade de terapia intensiva pediátrica, suporte ventilatório/vasoativo, e morte ( p +2.5). Echocardiographic abnormalities were significantly associated with MIS-c, admission to the pediatric intensive care unit, multiple organ dysfunction, ventilatory/vasoactive support, and death (p
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- 2021
4. SARS‐CoV‐2 in children with cancer in Brazil: Results of a multicenter national registry
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Corso, Mariana Cristina M., primary, Soares, Victor J., additional, Amorim, Anna Maria P., additional, Cipolotti, Rosana, additional, Magalhães, Isis Maria Q., additional, Lins, Mecneide M., additional, Forsait, Silvana, additional, Silva, Luciana N., additional, Sousa, Ana Virginia L., additional, Alves, Nádia G., additional, Prado, Seila I., additional, Silva, Klerize Anecely S., additional, Carbone, Edna K., additional, Brumatti, Melina, additional, Santiago, Pablo, additional, Pereira, Kaline Maria M.O., additional, Carlesse, Fabianne A.M.C., additional, Aguiar, Marina G., additional, Marques, Rebeca F., additional, Rechenmacher, Ciliana, additional, Daudt, Liane E., additional, and Michalowski, Mariana B., additional
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- 2021
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5. Gastrointestinal manifestations are associated with severe pediatric COVID-19: A study in tertiary hospital
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de Paula, Camila Sanson Yoshino, primary, Palandri, Giovanna Gavros, additional, Fonseca, Taiane Siraisi, additional, Vendramini, Thaís Cristina Annibale, additional, Farhat, Sylvia Costa Lima, additional, Pereira, Maria Fernanda Badue, additional, Litvinov, Nadia, additional, Toma, Ricardo Katsuya, additional, de Sá, Fernanda Viveiros Moreira, additional, Rodrigues, Katharina Reichmann, additional, Schvartsman, Cláudio, additional, Forsait, Silvana, additional, Sakita, Neusa Keico, additional, Kanunfre, Kelly Aparecida, additional, Rocha, Mussya Cisotto, additional, dos Santos, Emilly Henrique, additional, Okay, Thelma Suely, additional, Pinho, João Renato Rebello, additional, de Carvalho, Werther Brunow, additional, Carneiro-Sampaio, Magda, additional, Almeida Silva, Clovis Artur, additional, Marques, Heloisa Helena de Sousa, additional, Eisencraft, Adriana Pasmanik, additional, Junior, Alfio Rossi, additional, Delgado, Artur Figueiredo, additional, Leal, Gabriela Nunes, additional, Framil, Juliana Valéria de Souza, additional, Gibelli, Maria Augusta Bento Cicaroni, additional, and Jorge, Patricia Palmeira Daenekas, additional
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- 2021
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6. O Coração de Pacientes Pediátricos com COVID-19: Novos Insights a Partir de um Estudo Ecocardiográfico Sistemático em um Hospital Terciário no Brasil
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Diniz, Maria de Fátima Rodrigues, primary, Cardoso, Maira Freire, additional, Sawamura, Karen Saori Shiraishi, additional, Menezes, Carolina Rocha Brito, additional, Lianza, Alessandro Cavalcanti, additional, Pereira, Maria Fernanda Badue, additional, Litvinov, Nadia, additional, Ferranti, Juliana Ferreira, additional, Forsait, Silvana, additional, Watanabe, Andreia, additional, Farhat, Sylvia Costa Lima, additional, Aikawa, Nadia Emi, additional, Campos, Lucia Maria Arruda, additional, Delgado, Artur Figueiredo, additional, Carneiro-Sampaio, Magda, additional, Carvalho, Werther Brunow de, additional, Silva, Clovis Artur, additional, and Leal, Gabriela Nunes, additional
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- 2021
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7. Persistent symptoms and decreased health-related quality of life after symptomatic pediatric COVID-19: A prospective study in a Latin American tertiary hospital
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Fink, Thais T., primary, Marques, Heloisa H.S., additional, Gualano, Bruno, additional, Lindoso, Livia, additional, Bain, Vera, additional, Astley, Camilla, additional, Martins, Fernanda, additional, Matheus, Denise, additional, Matsuo, Olivia M., additional, Suguita, Priscila, additional, Trindade, Vitor, additional, Paula, Camila S.Y., additional, Farhat, Sylvia C.L., additional, Palmeira, Patricia, additional, Leal, Gabriela N., additional, Suzuki, Lisa, additional, Odone, Vicente, additional, Carneiro-Sampaio, Magda, additional, Duarte, Alberto José S., additional, Antonangelo, Leila, additional, Batisttella, Linamara R., additional, Polanczyk, Guilherme V., additional, Pereira, Rosa Maria R., additional, Carvalho, Carlos Roberto R., additional, Buchpiguel, Carlos A., additional, Xavier, Ana Claudia L., additional, Seelaender, Marilia, additional, Silva, Clovis Artur, additional, Pereira, Maria Fernanda B., additional, Sallum, Adriana M.E., additional, Brentani, Alexandra V.M., additional, Neto, Álvaro José S., additional, Ihara, Amanda, additional, Santos, Andrea R., additional, Canton, Ana Pinheiro M., additional, Watanabe, Andreia, additional, Santos, Angélica C. dos, additional, Pastorino, Antonio C., additional, Franco, Bernadette D.G.M., additional, Caruzo, Bruna, additional, Ceneviva, Carina, additional, Martins, Carolina C.M.F., additional, Prado, Danilo, additional, Abellan, Deipara M., additional, Benatti, Fabiana B., additional, Smaria, Fabiana, additional, Gonçalves, Fernanda T., additional, Penteado, Fernando D., additional, Castro, Gabriela S. F. de, additional, Gonçalves, Guilherme S., additional, Roschel, Hamilton, additional, Disi, Ilana R., additional, Marques, Isabela G., additional, Castro, Inar A., additional, Buscatti, Izabel M., additional, Faiad, Jaline Z., additional, Fiamoncini, Jarlei, additional, Rodrigues, Joaquim C., additional, Carneiro, Jorge D.A., additional, Paz, Jose A., additional, Ferreira, Juliana C., additional, Ferreira, Juliana C.O., additional, Silva, Katia R., additional, Bastos, Karina L.M., additional, Kozu, Katia, additional, Cristofani, Lilian M., additional, Souza, Lucas V.B., additional, Campos, Lucia M.A., additional, Silva, Luiz Vicente R.F., additional, Sapienza, Marcelo T., additional, Lima, Marcos S., additional, Garanito, Marlene P., additional, Santos, Márcia F.A., additional, Dorna, Mayra B., additional, Aikawa, Nadia E., additional, Litvinov, Nadia, additional, Sakita, Neusa K., additional, Gaiolla, Paula V.V., additional, Pasqualucci, Paula, additional, Toma, Ricardo K., additional, Correa-Silva, Simone, additional, Sieczkowska, Sofia M., additional, Imamura, Marta, additional, Forsait, Silvana, additional, Santos, Vera A., additional, and Zheng, Yingying, additional
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- 2021
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8. Pediatric Heart in COVID-19: New Insights from a Systematic Echocardiographic Study in a Tertiary Brazilian Hospital
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Diniz, Maria de Fátima Rodrigues, primary, Cardoso, Maira Freire, additional, Sawamura, Karen Saori Shiraishi, additional, Brito Menezes, Carolina Rocha, additional, Lianza, Alessandro Cavalcanti, additional, Pereira, Maria Fernanda Bádue, additional, Litvinov, Nadia, additional, Ferranti, Juliana Ferreira, additional, Forsait, Silvana, additional, Watanabe, Andreia, additional, Farhat, Sylvia Costa Lima, additional, Aikawa, Nádia Emi, additional, Campos, Lúcia Maria M. Arruda, additional, Delgado, Artur Figueiredo, additional, Sampaio, Magda Carneiro, additional, de Carvalho, Werther Brunow, additional, Silva, Clovis Artur, additional, and Leal, Gabriela Nunes, additional
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- 2020
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9. An unusual abdominal wall mass in a child
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Souza, Amalia Maria do Espirito Santo, Barbuto, Tomas Marzagão, Freitas, Flávia Alessandra, Vianna, Nathalia Fernandes, Zanchetta, Carla Maria Costa, Forsait, Silvana, Borba, Claudio, Azambuja, Alessandra Milani Prandini de, Cristofani, Lilian Maria, and Odone Filho, Vicente
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Abdominal mass ,Ascaris lumbricoides ,Abdominal tumor in children - Abstract
Abdominal tumors are one of the most common types of pediatric cancer. Therefore, they should always be included in the differential diagnosis of abdominal masses. Here, we present the case of a child whose initial hypothesis of diagnosis contemplated this possibility. Later, it was demonstrated that the abdominal mass found was secondary to a common parasitosis. A 2-year old, moderately malnourished and pale white boy was referred with a history of a rapidly growing, well-limited, middle abdominal mass. The mass was 10 by 3 cm, hard and poorly movable, apparently involving both abdominal rectus muscles. A complete resection was performed, revealing an abdominal wall abscess, with intense eosinophilic proliferation, secondary to a local and intense reaction to innumerous Ascaris lumbricoides eggs. Extra luminal infestations with Ascaris, that usually form peritoneal granulomas have been previously described. However, neither external trauma nor fistula, that could explain the superficial presence of the eggs, was found. This description reinforces the relevance of infectious diseases within the differential diagnosis of abdominal masses, particularly in areas with high prevalence of parasitic infestations.
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- 2017
10. An unusual abdominal wall mass in a child
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Souza, Amalia Maria do Espirito Santo, primary, Barbuto, Tomas Marzagão, additional, Freitas, Flávia Alessandra, additional, Vianna, Nathalia Fernandes, additional, Zanchetta, Carla Maria Costa, additional, Forsait, Silvana, additional, Borba, Claudio, additional, Azambuja, Alessandra Milani Prandini de, additional, Cristofani, Lilian Maria, additional, and Odone Filho, Vicente, additional
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- 2017
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11. An unusual abdominal wall mass in a child.
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do Espirito Santo Souza, Amalia Maria, Barbuto, Tomas Marzagão, Freitas, Flávia Alessandra, Vianna, Nathalia Fernandes, Zanchetta, Carla Maria Costa, Forsait, Silvana, Borba, Claudio, de Azambuja, Alessandra Milani Prandini, Cristofani, Lilian Maria, and Filho, Vicente Odone
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CHILDREN'S health ,CHILD nutrition ,ABDOMINAL pain ,ABDOMINAL diseases ,ALVARADO score - Abstract
Abdominal tumors are one of the most common types of pediatric cancer. Therefore, they should always be included in the differential diagnosis of abdominal masses. Here, we present the case of a child whose initial hypothesis of diagnosis contemplated this possibility. Later, it was demonstrated that the abdominal mass found was secondary to a common parasitosis. A 2-year old, moderately malnourished and pale white boy was referred with a history of a rapidly growing, well-limited, middle abdominal mass. The mass was 10 by 3 cm, hard and poorly movable, apparently involving both abdominal rectus muscles. A complete resection was performed, revealing an abdominal wall abscess, with intense eosinophilic proliferation, secondary to a local and intense reaction to innumerous Ascaris lumbricoides eggs. Extra luminal infestations with Ascaris, that usually form peritoneal granulomas have been previously described. However, neither external trauma nor fistula, that could explain the superficial presence of the eggs, was found. This description reinforces the relevance of infectious diseases within the differential diagnosis of abdominal masses, particularly in areas with high prevalence of parasitic infestations. [ABSTRACT FROM AUTHOR]
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- 2017
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12. Standardization of a method to study angiogenesis in a mouse model
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FEDER, DAVID, primary, PERRAZO, FABIO F., additional, PEREIRA, EDIMAR C., additional, FORSAIT, SILVANA, additional, FEDER, CECILIA K.R., additional, JUNQUEIRA, PAULO E.B., additional, JUNQUEIRA, VIRGINIA B.C., additional, AZZALIS, LIGIA A., additional, and FONSECA, FERNANDO L.A., additional
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- 2013
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13. Impacto do diagnóstico e do tratamento de câncer e de Aids no cotidiano e nas redes sociais de crianças e adolescentes
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Forsait, Silvana, primary, Castellanos, Marcelo Eduardo Pfeiffer, additional, Cordenonssi, Julianne Tannous, additional, Vicentini, Lara Lys, additional, Silva, Marina Maria Biella, additional, Miranda, Michele Da Costa, additional, Magalhães, Natália Pereira de, additional, and Cartum, Jairo, additional
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- 2009
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14. Differences in children and adolescents with SARS-CoV-2 infection: a cohort study in a Brazilian tertiary referral hospital.
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Marques HHS, Pereira MFB, Santos ACD, Fink TT, Paula CSY, Litvinov N, Schvartsman C, Delgado AF, Gibelli MABC, Carvalho WB, Odone Filho V, Tannuri U, Carneiro-Sampaio M, Grisi S, Duarte AJDS, Antonangelo L, Francisco RPV, Okay TS, Batisttella LR, Carvalho CRR, Brentani AVM, Silva CA, Eisencraft AP, Rossi Junior A, Fante AL, Cora AP, Reis AGAC, Ferrer APS, Andrade APM, Watanabe A, Gonçalves AMF, Waetge ARP, Silva CA, Ceneviva C, Lazari CDS, Abellan DM, Santos EHD, Sabino EC, Bianchini FRM, Alcantara FFP, Ramos GF, Leal GN, Rodriguez IS, Pinho JRR, Carneiro JDA, Paz JA, Ferreira JC, Ferranti JF, Ferreira JOA, Framil JVS, Silva KRD, Kanunfre KA, Bastos KLM, Galleti KV, Cristofani LM, Suzuki L, Campos LMA, Perondi MBM, Diniz MFR, Fonseca MFM, Cordon MNA, Pissolato M, Peres MS, Garanito MP, Imamura M, Dorna MB, Luglio M, Rocha MC, Aikawa NE, Degaspare NV, Sakita NK, Udsen NL, Scudeller PG, Gaiolla PVV, Severini RDSG, Rodrigues RM, Toma RK, Paula RIC, Palmeira P, Forsait S, Farhat SCL, Sakano TMS, Koch VHK, and Cobello Junior V
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- Adolescent, Child, Cohort Studies, Cross-Sectional Studies, Humans, Infant, Newborn, SARS-CoV-2, Systemic Inflammatory Response Syndrome, Tertiary Care Centers, COVID-19 complications
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Objectives: To compare demographic/clinical/laboratory/treatments and outcomes among children and adolescents with laboratory-confirmed coronavirus disease 2019 (COVID-19)., Methods: This was a cross-sectional study that included patients diagnosed with pediatric COVID-19 (aged <18 years) between April 11, 2020 and April 22, 2021. During this period, 102/5,951 (1.7%) of all admissions occurred in neonates, children, and adolescents. Furthermore, 3,962 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection samples were processed in patients aged <18 years, and laboratory-confirmed COVID-19 occurred in 155 (4%) inpatients and outpatients. Six/155 pediatric patients were excluded from the study. Therefore, the final group included 149 children and adolescents (n=97 inpatients and 52 outpatients) with positive SARS-CoV-2 results., Results: The frequencies of sore throat, anosmia, dysgeusia, headache, myalgia, nausea, lymphopenia, pre-existing chronic conditions, immunosuppressive conditions, and autoimmune diseases were significantly reduced in children and adolescents (p<0.05). Likewise, the frequencies of enoxaparin use (p=0.037), current immunosuppressant use (p=0.008), vasoactive agents (p=0.045), arterial hypotension (p<0.001), and shock (p=0.024) were significantly lower in children than in adolescents. Logistic regression analysis showed that adolescents with laboratory-confirmed COVID-19 had increased odds ratios (ORs) for sore throat (OR 13.054; 95% confidence interval [CI] 2.750-61.977; p=0.001), nausea (OR 8.875; 95% CI 1.660-47.446; p=0.011), and lymphopenia (OR 3.575; 95% CI 1.355-9.430; p=0.010), but also had less hospitalizations (OR 0.355; 95% CI 0.138-0.916; p=0.032). The additional logistic regression analysis on patients with preexisting chronic conditions (n=108) showed that death as an outcome was significantly associated with pediatric severe acute respiratory syndrome (SARS) (OR 22.300; 95% CI 2.341-212.421; p=0.007) and multisystem inflammatory syndrome in children (MIS-C) (OR 11.261; 95% CI 1.189-106. 581; p=0.035)., Conclusions: Half of the laboratory-confirmed COVID-19 cases occurred in adolescents. Individuals belonging to this age group had an acute systemic involvement of SARS-CoV-2 infection. Pediatric SARS and MIS-C were the most important factors associated with the mortality rate in pediatric chronic conditions with COVID-19.
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- 2021
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15. The Heart of Pediatric Patients with COVID-19: New Insights from a Systematic Echocardiographic Study in a Tertiary Hospital in Brazil.
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Diniz MFR, Cardoso MF, Sawamura KSS, Menezes CRB, Lianza AC, Pereira MFB, Litvinov N, Ferranti JF, Forsait S, Watanabe A, Farhat SCL, Aikawa NE, Campos LMA, Delgado AF, Carneiro-Sampaio M, Carvalho WB, Silva CA, and Leal GN
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- Brazil epidemiology, Child, Echocardiography, Humans, Longitudinal Studies, Male, Retrospective Studies, SARS-CoV-2, Tertiary Care Centers, COVID-19, Pandemics
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Background: COVID-19 pandemic represents a huge burden to the health system in the world. Although pediatric COVID-19 patients have been relatively spared compared with adults, recent reports showed an increasing number of critically ill patients with multisystemic inflammatory syndrome in children (MIS-c), with marked cardiovascular impairment. Nevertheless, little is known about the relationship between cardiac abnormalities and inflammatory and coagulation biomarkers., Objectives: to investigate echocardiographic abnormalities in pediatric patients with COVID-19 admitted to tertiary hospital., Methods: this was a retrospective longitudinal study, based on the review of medical records and echocardiograms of patients (0-19 years) admitted to a tertiary hospital between March 30 and June 30, 2020. For statistical analysis, the significance level was set at 5% (p < 0.05)., Results: Forty-eight patients were enrolled, 73% with preexisting diseases, 20 (41.7%) with MIS-c. Median age was 7.5 (0-18.6) years; 27 (56.2%) were male. Median duration of hospitalization was 15.4 (2-92) days and seven (14.6%) patients died. A total of 70 echocardiograms were performed; 66.7% patients were scanned only once and 33.3% multiple times. Twenty-three (48%) patients showed echocardiographic abnormalities: eight (16.6%) left ventricle (LV) systolic dysfunction, six (12.5%) right ventricle (RV) systolic dysfunction and 12 (25%) coronary dilatation (Z-score>+2.5). Echocardiographic abnormalities were significantly associated with MIS-c, admission to the pediatric intensive care unit, multiple organ dysfunction, ventilatory/vasoactive support, and death (p<0.05). Significantly higher d-dimer (ng/mL) levels were detected in patients with LV dysfunction [16733(4157-115668) vs. 2406.5(190-95040)], RV dysfunction [25769(3422-115668) vs. 2803.5(190-95040)] and coronary artery dilation [9652.5(921-115668) vs. 2724(190- 95040)] (p<0.05)., Conclusion: Echocardiographic abnormalities in COVID-19 pediatric patients were frequent and associated with worse clinical outcomes. Exacerbation of the inflammation and coagulation pathways may play an important role in cardiovascular injury in those patients.
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- 2021
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