1. Effect of meal volume and calorie load on postprandial gastric function and emptying: studies under physiological conditions by combined fiber-optic pressure measurement and MRI
- Author
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Kwiatek, Monika A., Menne, Dieter, Steingoetter, Andreas, Goetze, Oliver, Forras-Kaufman, Zsofia, Kaufman, Elad, Fruehauf, Heiko, Boesiger, Peter, Fried, Michael, Schwizer, Werner, and Fox, Mark R.
- Subjects
Magnetic resonance imaging -- Methods ,Pressure -- Measurement ,Pressure -- Methods ,Gastrointestinal system -- Motility ,Gastrointestinal system -- Research ,Fiber optics -- Equipment and supplies ,Fiber optics -- Usage ,Biological sciences - Abstract
This study assessed the effects of meal volume (MV) and calorie load (CL) on gastric function. MRI and a minimally invasive fiber-optic recording system (FORS) provided simultaneous measurement of gastric volume and pressure changes during gastric tilting and emptying of a liquid nutrient meal in physiological conditions. The gastric response to 12 iso-osmolar MV-CL combinations of a multinutrient drink (MV: 200, 400, 600, 800 ml; CL: 200, 300, 400 kcal) was tested in 16 healthy subjects according to a factorial design. Total gastric volume (TGV) and gastric content volume (GCV = MV + secretion) were measured by MRI during nasogastric meal infusion and gastric emptying over 60 min. Intragastric pressure was assessed at 1 Hz by FORS. The dynamic change in postprandial gastric volumes was described by a validated three-component linear exponential model. The stomach expanded with MV, but the ratio of GCV:MV at [t.sub.0] diminished with increasing MV (P < 0.01). Postprandial changes in TGV followed those of GCV. Intragastric pressure increased with MV, and this effect was augmented further by CL (P = 0.02); however, the absolute pressure rise was gastric accommodation; gastric emptying; intragastric pressure doi: 10.1152/ajpgi.00117.2009.
- Published
- 2009