661 results on '"Forni, Lui G."'
Search Results
2. Hepatorenal syndrome in the intensive care unit
- Author
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Nadim, Mitra K., Forni, Lui G., and Ostermann, Marlies
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- 2024
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3. Terlipressin use in HRS–AKI and respiratory failure. Author's reply
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Nadim, Mitra K., Forni, Lui G., and Ostermann, Marlies
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- 2024
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4. Vitamin D metabolism in critically ill patients with acute kidney injury: a prospective observational study
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Cameron, Lynda K., Ledwaba-Chapman, Lesedi, Voong, Kieran, Hampson, Geeta, Forni, Lui G., Seylanova, Nina, Harrington, Dominic J., Lim, Rosario, Bociek, Aneta, Yanzhong, Wang, and Ostermann, Marlies
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- 2024
- Full Text
- View/download PDF
5. Designing acute kidney injury clinical trials
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Zarbock, Alexander, Forni, Lui G., Ostermann, Marlies, Ronco, Claudio, Bagshaw, Sean M., Mehta, Ravindra L., Bellomo, Rinaldo, and Kellum, John A.
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- 2024
- Full Text
- View/download PDF
6. Digital health and acute kidney injury: consensus report of the 27th Acute Disease Quality Initiative workgroup
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Kashani, Kianoush B., Awdishu, Linda, Bagshaw, Sean M., Barreto, Erin F., Claure-Del Granado, Rolando, Evans, Barbara J., Forni, Lui G., Ghosh, Erina, Goldstein, Stuart L., Kane-Gill, Sandra L., Koola, Jejo, Koyner, Jay L., Liu, Mei, Murugan, Raghavan, Nadkarni, Girish N., Neyra, Javier A., Ninan, Jacob, Ostermann, Marlies, Pannu, Neesh, Rashidi, Parisa, Ronco, Claudio, Rosner, Mitchell H., Selby, Nicholas M., Shickel, Benjamin, Singh, Karandeep, Soranno, Danielle E., Sutherland, Scott M., Bihorac, Azra, and Mehta, Ravindra L.
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- 2023
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7. Hemoadsorption
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Bellomo, Rinaldo, Mehta, Ravindra L., Forni, Lui G., Zarbock, Alexander, Ostermann, Marlies, Ronco, Claudio, Ankawi, Ghada, Bagshaw, Sean M., Baldwin, Ian, Basu, Rajit, Bottari, Gabriella, Cantaluppi, Vincenzo, Clark, William, De Rosa, Silvia, Forni, Lui G., Fuhrman, Dana, Gomez, Hernando, Husain-Syed, Faeq, Joannidis, Michael, Kashani, Kianoush, Lorenzin, Anna, Mehta, Ravindra, Murray, Patrick T., Murugan, Ragi, Ostermann, Marlies, Pannu, Neesh, Premuzic, Vedran, Prowle, John, Reis, Thiago, Rimmelé, Thomas, Rosner, Mitch, Schneider, Antoine, See, Emily, Soranno, Danielle, Villa, Gianluca, Whaley-Connell, Adam, and Zarbock, Alexander
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- 2024
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8. Update on sepsis-associated acute kidney injury : emerging targeted therapies
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Doyle, James F. and Forni, Lui G.
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- 2016
9. Tackling sepsis-associated AKI: are there any chances of REVIVAL with new approaches?
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Prowle, John R., Bagshaw, Sean M., and Forni, Lui G.
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- 2024
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10. Statistical analysis plan for the biomarker-guided intervention to prevent acute kidney injury after major surgery (BigpAK-2) study: An international randomised controlled multicentre trial
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Wempe, Carola, Storck, Michael, Brix, Tobias, Strauss, Christian, Sadjadi, Mahan, Weiss, Raphael, Booke, Hendrik, Loomann, Lisa, Amini, Wida, Meschede, Dana, Göbel, Ulrich, Haaker, Jan Gerrit, Brenner, Thorsten, Espeter, Florian, Rahmel, Tim, Adamzik, Michael, Brandenburger, Timo, Putensen, Christian, Bode, Christian, Kruse, Philippe, Wild, Lennart, Rosenberger, Peter, Bernard, Alice, Jung-König, Mona, Larmann, Jan, Reutershan, Jörg, Arndt, Christian, Vojnar, Benjamin, Spieth, Peter M., Schneider, Antoine, Monard, Céline, Mura, Benedetta, Villa, Gianluca, Laici, Cristiana, Siniscalchi, Antonio, Capozzi, Chiara, Sita, Marco, Cattin, Lucia, de Rosa, Silvia, Spadaro, Savino, Franco, D'Arcangelo Benito, Ostermann, Marlies, Gossage, James, Verzelloni, Alessandra, Scaramuzzi, Marco, Glass, Adam, Silversides, Jon, Lonsdale, Elliot, Forni, Lui G., Haider, Syeda, Rossiter, Adam, Welters, Ingeborg, Hoste, Eric, Hollmann, Markus W., Ripollés-Melchor, Javier, Fernández-Valdes-Bango, Paula, Parise-Roux, Diego, Martin González, Maria Carmen, Bathal, Irene Romero, Jáuregui, Maider Puyada, Navarro-Perez, Rosalía, De Soto, Inés, García-Álvarez, Raquel, Sánchez, Elena Murcia, Suarez-de-la-Rica, Alejandro, Lalande, Robin, von Groote, Thilo, Danzer, Moritz Fabian, Meersch, Melanie, Zarbock, Alexander, and Gerß, Joachim
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- 2024
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11. Proenkephalin as a biomarker correlates with acute kidney injury: a systematic review with meta-analysis and trial sequential analysis
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Lin, Li-Chun, Chuan, Min-Hsiang, Liu, Jung-Hua, Liao, Hung-Wei, Ng, Leong L., Magnusson, Martin, Jujic, Amra, Pan, Heng-Chih, Wu, Vin-Cent, and Forni, Lui G.
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- 2023
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12. Acute kidney injury
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Joannidis, Michael, Meersch-Dini, Melanie, and Forni, Lui G.
- Subjects
Fresenius Medical Care AG & Company KGaA ,Baxter Healthcare Corp. ,Medical colleges ,Hospital patients ,Kidney diseases ,Health care industry - Abstract
Author(s): Michael Joannidis [sup.1], Melanie Meersch-Dini [sup.2], Lui G. Forni [sup.3] [sup.4] Author Affiliations: (1) grid.5361.1, 0000 0000 8853 2677, Division of Intensive Care and Emergency Medicine, Department of Internal [...]
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- 2023
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13. Sepsis-associated acute kidney injury: consensus report of the 28th Acute Disease Quality Initiative workgroup
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Zarbock, Alexander, Nadim, Mitra K., Pickkers, Peter, Gomez, Hernando, Bell, Samira, Joannidis, Michael, Kashani, Kianoush, Koyner, Jay L., Pannu, Neesh, Meersch, Melanie, Reis, Thiago, Rimmelé, Thomas, Bagshaw, Sean M., Bellomo, Rinaldo, Cantaluppi, Vicenzo, Deep, Akash, De Rosa, Silvia, Perez-Fernandez, Xose, Husain-Syed, Faeq, Kane-Gill, Sandra L., Kelly, Yvelynne, Mehta, Ravindra L., Murray, Patrick T., Ostermann, Marlies, Prowle, John, Ricci, Zaccaria, See, Emily J., Schneider, Antoine, Soranno, Danielle E., Tolwani, Ashita, Villa, Gianluca, Ronco, Claudio, and Forni, Lui G.
- Published
- 2023
- Full Text
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14. Regional Practice Variation and Outcomes in the Standard Versus Accelerated Initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI) Trial: A Post Hoc Secondary Analysis
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Vaara, Suvi T., Serpa Neto, Ary, Bellomo, Rinaldo, Adhikari, Neill K. J., Dreyfuss, Didier, Gallagher, Martin, Gaudry, Stephane, Hoste, Eric, Joannidis, Michael, Pettilä, Ville, Wang, Amanda Y., Kashani, Kianoush, Wald, Ron, Bagshaw, Sean M., Ostermann, Marlies, Bagshaw, Sean M, Wald, Ron, Adhikari, Neill K.J., Bellomo, Rinaldo, Dreyfuss, Didier, Du, Bin, Gallagher, Martin P., Gaudry, Stéphane, Hoste, Eric A., Lamontagne, François, Joannidis, Michael, Liu, Kathleen D., McAuley, Daniel F., McGuinness, Shay P., Nichol, Alistair D., Ostermann, Marlies, Palevsky, Paul M., Qiu, Haibo, Pettilä, Ville, Schneider, Antoine G., Smith, Orla M., Vaara, Suvi T., Weir, Matthew, Bellomo, Rinaldo, Eastwood, Glenn M., Peck, Leah, Young, Helen, Kruger, Peter, Laurie, Gordon, Saylor, Emma, Meyer, Jason, Venz, Ellen, Wetzig, Krista, French, Craig, McGain, Forbes, Mulder, John, Fennessy, Gerard, Koottayi, Sathyajith, Bates, Samantha, Towns, Miriam, Morgan, Rebecca, Tippett, Anna, Udy, Andrew, Mason, Chris, Licari, Elisa, Gantner, Dashiell, McClure, Jason, Nichol, Alistair, McCracken, Phoebe, Board, Jasmin, Martin, Emma, Vallance, Shirley, Young, Meredith, Vladic, Chelsey, McGloughlin, Steve, Gattas, David, Buhr, Heidi, Coles, Jennifer, Hutch, Debra, Wun, James, Cole, Louise, Whitehead, Christina, Lowrey, Julie, Masters, Kristy, Gresham, Rebecca, Campbell, Victoria, Gutierrez, David, Brailsford, Jane, Forbes, Loretta, Murray, Lauren, Maguire, Teena, NiChonghaile, Martina, Orford, Neil, Bone, Allison, Elderkin, Tania, Salerno, Tania, Chimunda, Tim, Fletcher, Jason, Broadfield, Emma, Porwal, Sanjay, Knott, Cameron, Boschert, Catherine, Smith, Julie, Richardson, Angus, Hill, Dianne, Duke, Graeme, Oziemski, Peter, Cegarra, Santiago, Chan, Peter, Welsh, Deborah, Hunter, Stephanie, Roodenburg, Owen, Dyett, John, Kokotsis, Nicos, Moser, Max, Yang, Yang, Padayachee, Laven, Vetro, Joseph, Gangopadhyay, Himangsu, Kaufman, Melissa, Ghosh, Angaj, Said, Simone, Patel, Alpesh, Bihari, Shailesh, Matheson, Elisha, Jin, Xia, Shrestha, Tapaswi, Schwartz, Kate, Gallagher, Martin P., Cross, Rosalba, Cheung, Winston, Wong, Helen, Kol, Mark, Shah, Asim, Wang, Amanda Y., Endre, Zoltan, Bradford, Celia, Janin, Pierre, Finfer, Simon, Diel, Naomi, Gatward, Jonathan, Hammond, Naomi, Delaney, Anthony, Bass, Frances, Yarad, Elizabeth, Buscher, Hergen, Reynolds, Claire, Baker, Nerilee, Joannidis, Michael, Bellmann, Romuald, Peer, Andreas, Hasslacher, Julia, Koglberger, Paul, Klein, Sebastian, Zotter, Klemens, Brandtner, Anna, Finkenstedt, Armin, Ditlbacher, Adelheid, Hartig, Frank, Fries, Dietmar, Bachler, Mirjam, Schenk, Bettina, Wagner, Martin, Staudinger, Thomas, Tiller, Esther, Schellongowski, Peter, Bojic, Andja, Hoste, Eric A., Bracke, Stephanie, De Crop, Luc, Vermeiren, Daisy, Thome, Fernando, Chiella, Bianca, Fendt, Lucia, Antunes, Veronica, Maisonneuve-Rosemont, Lafrance, Jean-Philippe, Lamontagne, François, D’Aragon, Frédérick, St-Arnaud, Charles, Mayette, Michael, Carbonnaeu, Élaine, Marchand, Joannie, Masse, Marie-Hélène, Ladouceur, Marilène, Turgeon, Alexis F., Lauzier, François, Bellemare, David, Langis Francoeur, Charles, LeBlanc, Guillaume, Guilbault, Gabrielle, Grenier, Stéphanie, Cloutier, Eve, Boivin, Annick, Delisle-Thibault, Charles, Giannakouros, Panagiota, Costerousse, Olivier, Cailhier, Jean-François, Carrier, François-Martin, Ghamraoui, Ali, Lebrasseur, Martine, Benettaib, Fatna, Salamé, Maya, Boumahni, Dounia, Tung Sia, Ying, Naud, Jean-François, Roy, Isabelle, Stelfox, Henry T., Ruddell, Stacey, Manns, Braden J., Duggan, Shelley, Carney, Dominic, Barchard, Jennifer, Whitlock, Richard P., Belley-Cote, Emilie, Savija, Nevena, Sabev, Alexandra, Campbell, Troy, Creary, Thais, Devereaux, Kelson, Brodutch, Shira, Rigatto, Claudio, Paunovic, Bojan, Mooney, Owen, Glybina, Anna, Harasemiw, Oksana, Di Nella, Michelle, Harmon, John, Mehta, Navdeep, Lakatos, Louis, Haslam, Nicole, Lellouche, Francois, Simon, Mathieu, Tung, Ying, Lizotte, Patricia, Bourchard, Pierre-Alexandre, Rochwerg, Bram, Karachi, Tim, Millen, Tina, Muscedere, John, Maslove, David, Gordon Boyd, J., Sibley, Stephanie, Drover, John, Hunt, Miranda, Georgescu, Ilinca, Wax, Randy, Lenga, Ilan, Sridhar, Kavita, Steele, Andrew, Fusco, Kelly, Ghate, Taneera, Tolibas, Michael, Robinson, Holly, Weir, Matthew A., Taneja, Ravi, Ball, Ian M., Garg, Amit, Campbell, Eileen, Ovsenek, Athena, Bagshaw, Sean M., van Diepen, Sean, Baig, Nadia, Magder, Sheldon, Yao, Han, Alam, Ahsan, Campisi, Josie, MacIntyre, Erika, Rokosh, Ella, Scherr, Kimberly, Lapinsky, Stephen, Mehta, Sangeeta, Shah, Sumesh, Niven, Daniel J., Stelfox, Henry T., Ruddell, Stacey, Russell, Michael, Jim, Kym, Brown, Gillian, Oxtoby, Kerry, Hall, Adam, Benoit, Luc, Sokolowski, Colleen, Prasad, Bhanu, Rao, Jag, Giebel, Shelley, Kutsogiannis, Demetrios J., Thompson, Patricia, Thompson, Tayne, Cirone, Robert, Kavikondala, Kanthi, Soth, Mark, Clarke, France, Takaoka, Alyson, Wald, Ron, Mazer, David, Burns, Karen, Friedrich, Jan, Klein, David, Sandhu, Gyan, Santos, Marlene, Khalid, Imrana, Hodder, 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Alexandre, Mayaux, Julien, Dres, Martin, Morawiec, Elise, Decalvele, Maxens, Demiri, Suela, Faure, Morgane, Marios, Clémence, Mallet, Maxime, Amélie Ordon, Marie, Morizot, Laura, Cantien, Marie, Pousset, François, Gaudry, Stéphane, Poirson, Florent, Cohen, Yves, Argaud, Laurent, Cour, Martin, Bitker, Laurent, Simon, Marie, Hernu, Romain, Baudry, Thomas, De La Salle, Sylvie, Robine, Adrien, Sedillot, Nicholas, Tchenio, Xavier, Bouisse, Camille, Roux, Sylvie, Barbar, Davide, Trusson, Rémi, Tamion, Fabienne, Grangé, Steven, Carpentier, Dorothée, Chevrel, Guillaume, Ensenyat-Martin, Luis, Marque, Sophie, Quenot, Jean-Pierre, Andreu, Pascal, Dargent, Auguste, Large, Audrey, Chudeau, Nicolas, Landais, Mickael, Derrien, Benoit, Christophe Callahan, Jean, Guitton, Christophe, Le Moal, Charlène, Robert, Alain, Asehnoune, Karim, Cinotti, Raphaël, Grillot, Nicolas, Demeure, Dominique, Vinsonneau, Christophe, Rahmani, Imen, Marzouk, Mehdi, Dekeyser, Thibault, Sejourne, Caroline, Verlay, Mélanie, Thevenin, Fabienne, Delecolle, Lucie, Didier Thevenin, Lens, Souweine, Bertrand, Coupez, Elisabeth, Adda, Mireille, Eraldi, Jean-Pierre, Marchalot, Antoine, De Prost, Nicolas, Mekontso Dessap, Armand, Razazi, Keyvan, Meziani, Ferhat, Boisrame-Helms, Julie, Clere-Jehl, Raphael, Delabranche, Xavier, Kummerlen, Christine, Merdji, Hamid, Monnier, Alexandra, Rabouel, Yannick, Rahmani, Hassene, Allam, Hayat, Chenaf, Samir, Franja, Vincenta, Pons, Bertrand, Carles, Michel, Martino, Frédéric, Richard, Régine, Zuber, Benjamin, Lacave, Guillaume, Lakhal, Karim, Rozec, Bertrand, Dang Van, Hoa, Boulet, Éric, Dubos, René, Fadel, Fouad, Cleophax, Cedric, Dufour, Nicolas, Grant, Caroline, Thuong, Marie, Reignier, Jean, Canet, Emmanuel, Nicolet, Laurent, Boulain, Thierry, Nay, Mai-Anh, Benzekri, Dalila, Barbier, François, Bretagnol, Anne, Kamel, Toufik, Mathonnet, Armelle, Muller, Grégoire, Skarzynski, Marie, Rossi, Julie, Pradet, Amandine, Dos Santos, Sandra, Guery, Aurore, Muller, Lucie, Felix, Luis, Bohé, Julien, Thiéry, Guillaume, Aissaoui, Nadia, Vimpere, Damien, Commeureuc, Morgane, Diehl, Jean-Luc, Guerot, Emmanuel, Liangos, Orfeas, Wittig, Monika, Zarbock, Alexander, Küllmar, Mira, van Waegeningh, Thomas, Rosenow, Nadine, Nichol, Alistair D., Brickell, Kathy, Doran, Peter, Murray, Patrick T., Landoni, Giovanni, Lembo, Rosalba, Zangrillo, Alberto, Monti, Giacomo, Tozzi, Margherita, Marzaroli, Matteo, Lombardi, Gaetano, Paternoster, Gianluca, Vitiello, Michelangelo, McGuinness, Shay, Parke, Rachael, Butler, Magdalena, Gilder, Eileen, Cowdrey, Keri-Anne, Wallace, Samantha, Hallion, Jane, Woolett, Melissa, Neal, Philippa, Duffy, Karina, Long, Stephanie, McArthur, Colin, Simmonds, Catherine, Chen, Yan, McConnochie, Rachael, Newby, Lynette, Knight, David, Henderson, Seton, Mehrtens, Jan, Morgan, Stacey, Morris, Anna, Vander Hayden, Kymbalee, Burke, Tara, Bailey, Matthew, Freebairn, Ross, Chadwick, Lesley, Park, Penelope, Rolls, Christine, Thomas, Liz, Buehner, Ulrike, Williams, Erin, Albrett, Jonathan, Kirkham, Simon, Jackson, Carolyn, Browne, Troy, Goodson, Jennifer, Jackson, David, Houghton, James, Callender, Owen, Higson, Vicki, Keet, Owen, Dominy, Clive, Young, Paul, Hunt, Anna, Judd, Harriet, Lawrence, Cassie, Olatunji, Shaanti, Robertson, Yvonne, Latimer-Bell, Charlotte, Hendry, Deborah, Mckay-Vucago, Agnes, Beehre, Nina, Lesona, Eden, Navarra, Leanlove, Robinson, Chelsea, Jang, Ryan, Junge, Andrea, Lambert, Bridget, Schneider, Antoine G., Thibault, Michel, Eckert, Philippe, Kissling, Sébastien, Polychronopoulos, Erietta, Poli, Elettra, Altarelli, Marco, Schnorf, Madeleine, Abed Mallaird, Samia, Heidegger, Claudia, Perret, Aurelie, Montillier, Philippe, Sangla, Frederic, Neils, Seigenthaller, De Watteville, Aude, Phull, Mandeep-Kaur, George, Aparna, Hussain, Nauman, Pogreban, Tatiana, Lobaz, Steve, Daniels, Alison, Cunningham, Mishell, Kerr, Deborah, Nicholson, Alice, Shanmugasundaram, Pradeep, Abrams, Judith, Manso, Katarina, Hambrook, Geraldine, McKerrow, Elizabeth, Salva, Juvy, Foulkes, Stephen, Wise, Matthew, Morgan, Matt, Brooks, Jenny, Cole, Jade, Michelle Davies, Tracy, Hill, Helen, Thomas, Emma, Vizcaychipi, Marcela, Baharlo, Behrad, Carungcong, Jaime, Costa, Patricia, Martins, Laura, Kapoor, Ritoo, Hazelton, Tracy, Moon, Angela, Musselwhite, Janine, Shelley, Ben, McCall, Philip, Ostermann, Marlies, Arbane, Gill, Bociek, Aneta, Marotti, Martina, Lim, Rosario, Campos, Sara, Grau Novellas, Neus, Cennamo, Armando, Slack, Andrew, Wyncoll, Duncan, Camporota, Luigi, Sparkes, Simon, Tilley, Rosalinde, Rattray, Austin, Moreland, Gayle, Duffy, Jane, McGonigal, Elizabeth, Hopkins, Philip, Finney, Clare, Smith, John, Noble, Harriet, Watson, Hayley, Harris, Claire-Louise, Clarey, Emma, Corcoran, Eleanor, Beck, James, Howcroft, Clare, Youngs, Nora, Wilby, Elizabeth, Ogg, Bethan, Wolverson, Adam, Lee, Sandra, Butler, Susie, Okubanjo, Maryanne, Hindle, Julia, Welters, Ingeborg, Williams, Karen, Johnson, Emily, Patrick-Heselton, Julie, Shaw, David, Waugh, Victoria, Stewart, Richard, Mwaura, Esther, Wren, Lynn, Mew, Louise, Sutherland, Sara-Beth, Adderley, Jane, Ruddy, Jim, Harkins, Margaret, Kaye, Callum, Scott, Teresa, Mitchell, Wendy, Anderson, Felicity, Willox, Fiona, Jagannathan, Vijay, Clark, Michele, Purv, Sarah, Sharman, Andrew, Meredith, Megan, Ryan, Lucy, Conner, Louise, Peters, Cecilia, Harvey, Dan, Roshdy, Ashraf, Collins, Amy, Sim, Malcolm, Henderson, Steven, Chee, Nigel, Pitts, Sally, Bowman, Katie, Dilawershah, Maria, Vamplew, Luke, Howe, Elizabeth, Rogers, Paula, Hernandez, Clara, Prendergast, Clara, Benton, Jane, Rosenberg, Alex, Forni, Lui G., Grant, Alice, Carvelli, Paula, Raithatha, Ajay, Bird, Sarah, Richardson, Max, Needham, Matthew, Hirst, Claire, Ball, Jonathan, Leaver, Susannah, Howlett, Luisa, Castro Delgado, Carlos, Farnell-Ward, Sarah, Farrah, Helen, Gray, Geraldine, Joseph, Gipsy, Robinson, Francesca, Tridente, Ascanio, Harrop, Clare, Shuker, Karen, McLaughlan, Derek, Ramsey, Judith, Meehan, Sharon, Oliver Rose, Bernd, Reece-Anthony, Rosie, Gurung, Babita, Whitehouse, Tony, Snelson, Catherine, Veenith, Tonny, Johnston, Andy, Cooper, Lauren, Carrera, Ron, Ellis, Karen, Fellows, Emma, Harkett, Samanth, Bergin, Colin, Spruce, Elaine, Despy, Liesl, Goundry, Stephanie, Dooley, Natalie, Mason, Tracy, Clark, Amy, Dignam, Gemma, Ward, Geraldine, Attwood, Ben, Parsons, Penny, Mason, Sophie, Margarson, Michael, Lord, Jenny, McGlone, Philip, Hodgson, Luke E., Chadbourn, Indra, Gomez, Raquel, Margalef, Jordi, Pretorius, Rinus, Hamshere, Alexandra, Carter, Joseph, Cahill, Hazel, Grainger, Lia, Howard, Kate, Forshaw, Greg, Guy, Zoe, Kashani, Kianoush B., Albright, Robert C., Amsbaugh, Amy, Stoltenberg, Anita, Niven, Alexander S., Lynch, Matthew, O’Mara, AnnMarie, Naeem, Syed, Sharif, Sairah, McKenney Goulart, Joyce, Lynch, Matthew, O’Mara, AnnMarie, Naeem, Syed, Sharif, Sairah, McKenney Goulart, Joyce, Tolwani, Ashita, Lyas, Claretha, Latta, Laura, Bihorac, Azra, Hashemighouchani, Haleh, Efron, Philip, Ruppert, Matthew, Cupka, Julie, Kiley, Sean, Carson, Joshua, White, Peggy, Omalay, George, Brown, Sherry, Velez, Laura, Marceron, Alina, Neyra, Javier A., Carlos Aycinena, Juan, Elias, Madona, Ortiz-Soriano, Victor M., Hauschild, Caroline, and Dorfman, Robert
- Published
- 2024
- Full Text
- View/download PDF
15. Postoperative acute kidney injury in adult non-cardiac surgery: joint consensus report of the Acute Disease Quality Initiative and PeriOperative Quality Initiative
- Author
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Prowle, John R, Forni, Lui G, Bell, Max, Chew, Michelle S, Edwards, Mark, Grams, Morgan E, Grocott, Michael PW, Liu, Kathleen D, McIlroy, David, Murray, Patrick T, Ostermann, Marlies, Zarbock, Alexander, Bagshaw, Sean M, Bartz, Raquel, Bell, Samira, Bihorac, Azra, Gan, Tong J, Hobson, Charles E, Joannidis, Michael, Koyner, Jay L, Levett, Denny ZH, Mehta, Ravindra L, Miller, Timothy E, Mythen, Michael G, Nadim, Mitra K, Pearse, Rupert M, Rimmele, Thomas, Ronco, Claudio, Shaw, Andrew D, and Kellum, John A
- Subjects
Prevention ,Cardiovascular ,Patient Safety ,Clinical Research ,Kidney Disease ,Renal and urogenital ,Good Health and Well Being ,Acute Kidney Injury ,Humans ,Kidney ,Postoperative Complications ,Risk Factors ,Clinical Sciences ,Urology & Nephrology - Abstract
Postoperative acute kidney injury (PO-AKI) is a common complication of major surgery that is strongly associated with short-term surgical complications and long-term adverse outcomes, including increased risk of chronic kidney disease, cardiovascular events and death. Risk factors for PO-AKI include older age and comorbid diseases such as chronic kidney disease and diabetes mellitus. PO-AKI is best defined as AKI occurring within 7 days of an operative intervention using the Kidney Disease Improving Global Outcomes (KDIGO) definition of AKI; however, additional prognostic information may be gained from detailed clinical assessment and other diagnostic investigations in the form of a focused kidney health assessment (KHA). Prevention of PO-AKI is largely based on identification of high baseline risk, monitoring and reduction of nephrotoxic insults, whereas treatment involves the application of a bundle of interventions to avoid secondary kidney injury and mitigate the severity of AKI. As PO-AKI is strongly associated with long-term adverse outcomes, some form of follow-up KHA is essential; however, the form and location of this will be dictated by the nature and severity of the AKI. In this Consensus Statement, we provide graded recommendations for AKI after non-cardiac surgery and highlight priorities for future research.
- Published
- 2021
16. Renal function in very old critically ill patients
- Author
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Perschinka, Fabian, Boyer, Naomi, Forni, Lui G., and Joannidis, Michael
- Published
- 2023
- Full Text
- View/download PDF
17. When to discontinue renal replacement therapy. what do we know?
- Author
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Boyer, Naomi, Perschinka, F., Joannidis, Michael, and Forni, Lui G.
- Published
- 2023
- Full Text
- View/download PDF
18. Publisher Correction: COVID-19-associated acute kidney injury: consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup
- Author
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Nadim, Mitra K, Forni, Lui G, Mehta, Ravindra L, Connor, Michael J, Liu, Kathleen D, Ostermann, Marlies, Rimmelé, Thomas, Zarbock, Alexander, Bell, Samira, Bihorac, Azra, Cantaluppi, Vincenzo, Hoste, Eric, Husain-Syed, Faeq, Germain, Michael J, Goldstein, Stuart L, Gupta, Shruti, Joannidis, Michael, Kashani, Kianoush, Koyner, Jay L, Legrand, Matthieu, Lumlertgul, Nuttha, Mohan, Sumit, Pannu, Neesh, Peng, Zhiyong, Perez-Fernandez, Xose L, Pickkers, Peter, Prowle, John, Reis, Thiago, Srisawat, Nattachai, Tolwani, Ashita, Vijayan, Anitha, Villa, Gianluca, Yang, Li, Ronco, Claudio, and Kellum, John A
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Renal and urogenital ,Good Health and Well Being ,Urology & Nephrology ,Clinical sciences - Abstract
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
- Published
- 2020
19. COVID-19-associated acute kidney injury: consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup
- Author
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Nadim, Mitra K, Forni, Lui G, Mehta, Ravindra L, Connor, Michael J, Liu, Kathleen D, Ostermann, Marlies, Rimmelé, Thomas, Zarbock, Alexander, Bell, Samira, Bihorac, Azra, Cantaluppi, Vincenzo, Hoste, Eric, Husain-Syed, Faeq, Germain, Michael J, Goldstein, Stuart L, Gupta, Shruti, Joannidis, Michael, Kashani, Kianoush, Koyner, Jay L, Legrand, Matthieu, Lumlertgul, Nuttha, Mohan, Sumit, Pannu, Neesh, Peng, Zhiyong, Perez-Fernandez, Xose L, Pickkers, Peter, Prowle, John, Reis, Thiago, Srisawat, Nattachai, Tolwani, Ashita, Vijayan, Anitha, Villa, Gianluca, Yang, Li, Ronco, Claudio, and Kellum, John A
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Prevention ,Kidney Disease ,Renal and urogenital ,Good Health and Well Being ,Acute Kidney Injury ,Anticoagulants ,COVID-19 ,Consensus ,Humans ,Renal Replacement Therapy ,Risk Factors ,SARS-CoV-2 ,Urology & Nephrology ,Clinical sciences - Abstract
Kidney involvement in patients with coronavirus disease 2019 (COVID-19) is common, and can range from the presence of proteinuria and haematuria to acute kidney injury (AKI) requiring renal replacement therapy (RRT; also known as kidney replacement therapy). COVID-19-associated AKI (COVID-19 AKI) is associated with high mortality and serves as an independent risk factor for all-cause in-hospital death in patients with COVID-19. The pathophysiology and mechanisms of AKI in patients with COVID-19 have not been fully elucidated and seem to be multifactorial, in keeping with the pathophysiology of AKI in other patients who are critically ill. Little is known about the prevention and management of COVID-19 AKI. The emergence of regional 'surges' in COVID-19 cases can limit hospital resources, including dialysis availability and supplies; thus, careful daily assessment of available resources is needed. In this Consensus Statement, the Acute Disease Quality Initiative provides recommendations for the diagnosis, prevention and management of COVID-19 AKI based on current literature. We also make recommendations for areas of future research, which are aimed at improving understanding of the underlying processes and improving outcomes for patients with COVID-19 AKI.
- Published
- 2020
20. Renin and Survival in Patients Given Angiotensin II for Catecholamine-Resistant Vasodilatory Shock. A Clinical Trial
- Author
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Bellomo, Rinaldo, Forni, Lui G, Busse, Laurence W, McCurdy, Michael T, Ham, Kealy R, Boldt, David W, Hästbacka, Johanna, Khanna, Ashish K, Albertson, Timothy E, Tumlin, James, Storey, Kristine, Handisides, Damian, Tidmarsh, George F, Chawla, Lakhmir S, and Ostermann, Marlies
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Hypertension ,Cardiovascular ,Clinical Research ,Clinical Trials and Supportive Activities ,Evaluation of treatments and therapeutic interventions ,6.1 Pharmaceuticals ,Aged ,Angiotensin II ,Biomarkers ,Catecholamines ,Female ,Humans ,Male ,Middle Aged ,Predictive Value of Tests ,Renin ,Shock ,Vasoconstrictor Agents ,angiotensin I ,renin-angiotensin-aldosterone system ,distributive shock ,angiotensin-converting enzyme defect ,renin–angiotensin–aldosterone system ,Medical and Health Sciences ,Respiratory System ,Cardiovascular medicine and haematology ,Clinical sciences - Abstract
Rationale: Exogenous angiotensin II increases mean arterial pressure in patients with catecholamine-resistant vasodilatory shock (CRVS). We hypothesized that renin concentrations may identify patients most likely to benefit from such therapy.Objectives: To test the kinetic changes in renin concentrations and their prognostic value in patients with CRVS.Methods: We analyzed serum samples from patients enrolled in the ATHOS-3 (Angiotensin II for the Treatment of High-Output Shock) trial for renin, angiotensin I, and angiotensin II concentrations before the start of administration of angiotensin II or placebo and after 3 hours.Measurements and Main Results: Baseline serum renin concentration (normal range, 2.13-58.78 pg/ml) was above the upper limits of normal in 194 of 255 (76%) study patients with a median renin concentration of 172.7 pg/ml (interquartile range [IQR], 60.7 to 440.6 pg/ml), approximately threefold higher than the upper limit of normal. Renin concentrations correlated positively with angiotensin I/II ratios (r = 0.39; P
- Published
- 2020
21. Quality of Care for Acute Kidney Disease: Current Knowledge Gaps and Future Directions
- Author
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Liu, Kathleen D, Forni, Lui G, Heung, Michael, Wu, Vin-Cent, Kellum, John A, Mehta, Ravindra L, Ronco, Claudio, Kashani, Kianoush, Rosner, Mitchell H, Haase, Michael, Koyner, Jay L, Investigators, Acute Disease Quality Initiative, and Mehta, Ravi
- Subjects
Health Services and Systems ,Biomedical and Clinical Sciences ,Clinical Sciences ,Health Sciences ,Kidney Disease ,Clinical Research ,Patient Safety ,Renal and urogenital ,Good Health and Well Being ,acute kidney injury ,outcomes ,quality ,recovery ,Acute Disease Quality Initiative Investigators ,Biomedical and clinical sciences ,Health sciences - Abstract
Acute kidney injury (AKI) and acute kidney disease (AKD) are common complications in hospitalized patients and are associated with adverse outcomes. Although consensus guidelines have improved the care of patients with AKI and AKD, guidance regarding quality metrics in the care of patients after an episode of AKI or AKD is limited. For example, few patients receive follow-up laboratory testing of kidney function or post-AKI or AKD care through nephrology or other providers. Recently, the Acute Disease Quality Initiative developed a consensus statement regarding quality improvement goals for patients with AKI or AKD specifically highlighting efforts regarding quality and safety of care after hospital discharge after an episode of AKI or AKD. The goal is to use these measures to identify opportunities for improvement that will positively affect outcomes. We recommend that health care systems quantitate the proportion of patients who need and actually receive follow-up care after the index AKI or AKD hospitalization. The intensity and appropriateness of follow-up care should depend on patient characteristics, severity, duration, and course of AKI of AKD, and should evolve as evidence-based guidelines emerge. Quality indicators for discharged patients with dialysis requiring AKI or AKD should be distinct from end-stage renal disease measures. Besides, there should be specific quality indicators for those still requiring dialysis in the outpatient setting after AKI or AKD. Given the limited preexisting data guiding the care of patients after an episode of AKI or AKD, there is ample opportunity to establish quality measures and potentially improve patient care and outcomes. This review will provide specific evidence-based and expert opinion-based guidance for the care of patients with AKI or AKD after hospital discharge.
- Published
- 2020
22. Controversies in acute kidney injury: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Conference
- Author
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Ostermann, Marlies, Bellomo, Rinaldo, Burdmann, Emmanuel A, Doi, Kent, Endre, Zoltan H, Goldstein, Stuart L, Kane-Gill, Sandra L, Liu, Kathleen D, Prowle, John R, Shaw, Andrew D, Srisawat, Nattachai, Cheung, Michael, Jadoul, Michel, Winkelmayer, Wolfgang C, Kellum, John A, Participants, Conference, Bagshaw, Sean M, Barreto, Erin F, Bihorac, Azra, Bobek, Ilona, Bouchard, Josée, Cerdá, Jorge, Chakravarthi, Rajasekara, De Rosa, Silvia, Engelman, Daniel T, Forni, Lui G, Hemmilä, Ulla K, Herzog, Charles A, Hoste, Eric A, Huen, Sarah C, Iseki, Kunitoshi, Joannidis, Michael, Kashani, Kianoush B, Koyner, Jay L, Kribben, Andreas, Lameire, Norbert, Levey, Andrew S, Macedo, Etienne, Małyszko, Jolanta, Meersch, Melanie, Mehta, Ravindra L, Mewburn, Irene, Mironova, Olga, Murray, Patrick T, Nadim, Mitra K, Pan, Jenny S, Pannu, Neesh, Peng, Zhiyong, Philips, Barbara, Ponce, Daniela, Ray, Patricio E, Ricci, Zaccaria, Rimmelé, Thomas, Ronco, Claudio, Siew, Edward D, Stevens, Paul E, Tolwani, Ashita J, Tonelli, Marcello, Vaara, Suvi T, van Dam, Marjel, Vijayan, Anitha, Wise, Michael, Wu, Vin-Cent, and Zarbock, Alexander
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Kidney Disease ,7.3 Management and decision making ,Management of diseases and conditions ,Renal and urogenital ,Acute Kidney Injury ,Humans ,acute kidney disease ,acute kidney injury ,fluid management ,nephrotoxicity ,renal replacement therapy ,risk stratification ,Conference Participants ,Urology & Nephrology ,Clinical sciences - Abstract
In 2012, Kidney Disease: Improving Global Outcomes (KDIGO) published a guideline on the classification and management of acute kidney injury (AKI). The guideline was derived from evidence available through February 2011. Since then, new evidence has emerged that has important implications for clinical practice in diagnosing and managing AKI. In April of 2019, KDIGO held a controversies conference entitled Acute Kidney Injury with the following goals: determine best practices and areas of uncertainty in treating AKI; review key relevant literature published since the 2012 KDIGO AKI guideline; address ongoing controversial issues; identify new topics or issues to be revisited for the next iteration of the KDIGO AKI guideline; and outline research needed to improve AKI management. Here, we present the findings of this conference and describe key areas that future guidelines may address.
- Published
- 2020
23. Predicting the Development of Renal Replacement Therapy Indications by Combining the Furosemide Stress Test and Chemokine (C-C Motif) Ligand 14 in a Cohort of Postsurgical Patients
- Author
-
Meersch, Melanie, Weiss, Raphael, Gerss, Joachim, Albert, Felix, Gruber, Janik, Kellum, John A., Chawla, Lakhmir, Forni, Lui G., Koyner, Jay L., von Groote, Thilo, and Zarbock, Alexander
- Published
- 2023
- Full Text
- View/download PDF
24. Marathon running and cell-cycle arrest biomarkers of acute kidney injury
- Author
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Leckie, Todd, Fitzpatrick, Daniel, Richardson, Alan J., Hunter, Alex, Bains, Sonia, Grimaldi, Rachael, Galloway, Rob, Forni, Lui G., and Hodgson, Luke E.
- Published
- 2023
- Full Text
- View/download PDF
25. Comparison of C-C motif chemokine ligand 14 with other biomarkers for adverse kidney events after cardiac surgery
- Author
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Massoth, Christina, Küllmar, Mira, Weiss, Raphael, Saadat-Gilani, Khaschayar, Roy-Ali, Tamara, Rossaint, Jan, Enders, Dominic, Kellum, John A., Forni, Lui G., Meersch, Melanie, and Zarbock, Alexander
- Published
- 2023
- Full Text
- View/download PDF
26. Is It Prime Time for NGAL?
- Author
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Forni, Lui G., primary and Mannemuddhu, S. Sudha, additional
- Published
- 2024
- Full Text
- View/download PDF
27. Serial Urinary C-C Motif Chemokine Ligand 14 and Risk of Persistent Severe Acute Kidney Injury
- Author
-
Prowle, John R., Artigas, Antonio, Bagshaw, Sean M., Forni, Lui G., Heung, Michael, Hoste, Eric, Marlies, Ostermann, Koyner, Jay L., Chawla, Lakmir, Kampf, J. Patrick, Kwan, Thomas, McPherson, Paul, Kellum, John A., Kashani, K, Al-Khafaji, A, Ardiles, T, Artigas, A, Bagshaw, SM, Bell, M, Bihorac, A, Birkhahn, R, Cely, CM, Chawla, LS, Davison, D, Feldkamp, T, Forni, LG, Gong, MN, Gunnerson, KJ, Haase, M, Hackett, J, Honore, P, Hoste, EAJ, Joannes-Boyau, O, Joannidis, M, Kim, P, Koyner, JL, Laskowitz, DT, Lissauer, ME, Marx, G, McCullough, PA, Mullaney, S, Ostermann, M, Rimmele, T, Shapiro, NI, Shaw, AD, Shi, J, Walker, MG, Sprague, AM, Vincent, JL, Vinsonneau, C, Wagner, L, Wilkerson, RG, Zacharowski, K, Kellum, JA, Hoste, Eric, Bihora, Azra, Al-Khafaji, Ali, Ortega, Luis M., Ostermann, Marlies, Haase, Michael, Zacharowski, Kai, Wunderink, Richard, Heung, Michael, Gunnerson, Kyle, Lissauer, Matthew, Herr, Daniel, Self, Wesley H., Koyner, Jay L., Honore, Patrick M., Prowle, John R., Davison, Danielle, Artigas, Antonio, Joannidis, Michael, Schroeder, Rebecca, Demirjian, Sevag, Forni, Lui G., Hodgson, Luke, Wilber, Scott T., Frey, Jennifer A., Reilly, Ian, Shi, Jing, Patrick Kampf, J., Kwan, Thomas, McPherson, Paul, Kellum, John A., and Chawla, Lakhmir S.
- Published
- 2023
- Full Text
- View/download PDF
28. The AKI care bundle: all bundle components are created equal-are they?
- Author
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von Groote, Thilo C., Ostermann, Marlies, Forni, Lui G., Meersch-Dini, Melanie, Zarbock, Alexander, Schmidt, Christoph, and Hoffmeier, Andreas
- Subjects
Acute renal failure -- Care and treatment ,Hemodynamic monitoring -- Methods ,Medical protocols -- Evaluation ,Critically ill -- Care and treatment ,Health care industry - Abstract
Author(s): Thilo C. von Groote [sup.1] , Marlies Ostermann [sup.2] , Lui G. Forni [sup.3] [sup.4] , Melanie Meersch-Dini [sup.1] , Alexander Zarbock [sup.1] , Christoph Schmidt, Andreas Hoffmeier, Hugo [...]
- Published
- 2022
- Full Text
- View/download PDF
29. COVID-19 and Acute Kidney Injury
- Author
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Hilton, James, Boyer, Naomi, Nadim, Mitra K., Forni, Lui G., and Kellum, John A.
- Published
- 2022
- Full Text
- View/download PDF
30. "Renal": The First Forbidden Word in the Medical Lexicon.
- Author
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Bellomo, Rinaldo, Kellum, John A., Reis, Thiago, Forni, Lui G., and Ronco, Claudio
- Subjects
MEDICAL language ,SCIENTIFIC communication ,RENAL replacement therapy ,MEDICAL periodicals ,SCIENTIFIC literature ,MEDICAL literature ,NEPHROLOGISTS - Abstract
This document discusses the controversy surrounding the use of the word "renal" in medical literature. Some journals have started to demand that the word be replaced with "kidney" in an effort to make articles more understandable to patients. However, many physicians argue that this policy is misguided and undermines academic freedom. They believe that the medical literature should facilitate communication among physicians worldwide and that it is not the purview of English-speaking journals to dictate changes in the global medical lexicon. The authors encourage researchers to choose journals that respect academic freedom and not submit their work to journals that enforce this language control. [Extracted from the article]
- Published
- 2024
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- View/download PDF
31. Cardiac and Vascular Surgery–Associated Acute Kidney Injury: The 20th International Consensus Conference of the ADQI (Acute Disease Quality Initiative) Group
- Author
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Nadim, Mitra K, Forni, Lui G, Bihorac, Azra, Hobson, Charles, Koyner, Jay L, Shaw, Andrew, Arnaoutakis, George J, Ding, Xiaoqiang, Engelman, Daniel T, Gasparovic, Hrvoje, Gasparovic, Vladimir, Herzog, Charles A, Kashani, Kianoush, Katz, Nevin, Liu, Kathleen D, Mehta, Ravindra L, Ostermann, Marlies, Pannu, Neesh, Pickkers, Peter, Price, Susanna, Ricci, Zaccaria, Rich, Jeffrey B, Sajja, Lokeswara R, Weaver, Fred A, Zarbock, Alexander, Ronco, Claudio, and Kellum, John A
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Good Health and Well Being ,Acute Kidney Injury ,Cardiac Surgical Procedures ,Consensus Development Conferences as Topic ,Humans ,Quality Improvement ,Vascular Surgical Procedures ,biomarker ,dialysis ,diuretics ,ischemia-reperfusion injury ,renal insufficiency ,ischemia–reperfusion injury ,Cardiorespiratory Medicine and Haematology ,Cardiovascular medicine and haematology - Published
- 2018
32. Hemoadsorption: Consensus report of the 30th Acute Disease Quality Initiative workgroup
- Author
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Ankawi, Ghada, primary, Bagshaw, Sean M, additional, Bellomo, Rinaldo, additional, Baldwin, Ian, additional, Basu, Rajit, additional, Bottari, Gabriella, additional, Cantaluppi, Vincenzo, additional, Clark, William, additional, De Rosa, Silvia, additional, Forni, Lui G, additional, Fuhrman, Dana, additional, Goldstein, Stuart, additional, Gomez, Hernando, additional, Husain-Syed, Faeq, additional, Joannidis, Michael, additional, Kashani, Kianoush, additional, Lorenzin, Anna, additional, Mehta, Ravindra, additional, Murray, Patrick T, additional, Murugan, Ragi, additional, Ostermann, Marlies, additional, Pannu, Neesh, additional, Premuzic, Vedran, additional, Prowle, John, additional, Reis, Thiago, additional, Rimmelé, Thomas, additional, Ronco, Claudio, additional, Rosner, Mitch, additional, Schneider, Antoine, additional, See, Emily, additional, Soranno, Danielle, additional, Villa, Gianluca, additional, Whaley-Connell, Adam, additional, and Zarbock, Alexander, additional
- Published
- 2024
- Full Text
- View/download PDF
33. Renal Physiology during Normal Pregnancy
- Author
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Savine, Rachel, Forni, Lui G., Einav, Sharon, editor, Weiniger, Carolyn F., editor, and Landau, Ruth, editor
- Published
- 2020
- Full Text
- View/download PDF
34. Covid-19 and acute kidney injury in hospital : summary of NICE guidelines
- Author
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Selby, Nicholas M, Forni, Lui G, Laing, Christopher M, Horne, Kerry L, Evans, Rhys DR, Lucas, Bethany J, and Fluck, Richard J
- Published
- 2020
35. Assessing the role of Chemokine (C–C motif) ligand 14 in AKI: a European consensus meeting.
- Author
-
Koyner, Jay L., Arndt, Christian, Baldira Martinez de Irujo, Jaume, Coelho, Sílvia, Garcia-Montesinos de la Peña, Manuel, di Girolamo, Luca, Joannidis, Michael, Jorge-Monjas, Pablo, Koch, Christian, Lobaz, Steven, Meyer, Alain, Ostermann, Marlies, Pertica, Nicoletta, Prowle, John R., Silversides, Jon, Zarbock, Alexander, Echeverri, Jorge, Harenski, Kai, and Forni, Lui G.
- Subjects
ACUTE kidney failure ,RENAL replacement therapy ,LIKERT scale - Abstract
Urinary Chemokine (C–C motif) ligand 14 (CCL14) is a biomarker associated with persistent severe acute kidney injury (AKI). There is limited data to support the implementation of this AKI biomarker to guide therapeutic actions. Sixteen AKI experts with clinical CCL14 experience participated in a Delphi-based method to reach consensus on when and how to potentially use CCL14. Consensus was defined as ≥ 80% agreement (participants answered with 'Yes', or three to four points on a five-point Likert Scale). Key consensus areas for CCL14 test implementation were: identifying challenges and mitigations, developing a comprehensive protocol and pairing it with a treatment plan, and defining the target population. The majority agreed that CCL14 results can help to prioritize AKI management decisions. CCL14 levels above the high cutoff (> 13 ng/mL) significantly changed the level of concern for modifying the AKI treatment plan (p < 0.001). The highest level of concern to modify the treatment plan was for discussions on renal replacement therapy (RRT) initiation for CCL14 levels > 13 ng/mL. The level of concern for discussion on RRT initiation between High and Low, and between Medium and Low CCL14 levels, showed significant differences. Real world urinary CCL14 use appears to provide improved care options to patients at risk for persistent severe AKI. Experts believe there is a role for CCL14 in AKI management and it may potentially reduce AKI-disease burden. There is, however, an urgent need for evidence on treatment decisions and adjustments based on CCL14 results. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
36. What every Intensivist should know about COVID-19 associated acute kidney injury
- Author
-
Ostermann, Marlies, Lumlertgul, Nuttha, Forni, Lui G., and Hoste, Eric
- Published
- 2020
- Full Text
- View/download PDF
37. CCL14 Predicts Oliguria and Dialysis Requirement in Patients with Moderate to Severe Acute Kidney Injury.
- Author
-
Demirjian, Sevag, Chawla, Lakhmir, Davison, Danielle, Forni, Lui G., Heung, Michael, Hoste, Eric A.J., Koyner, Jay, Kampf, J. Patrick, Kwan, Thomas, McPherson, Paul, and Kellum, John A.
- Subjects
ACUTE kidney failure ,HEMODIALYSIS patients ,LOGISTIC regression analysis ,REGRESSION analysis ,CRITICALLY ill - Abstract
Introduction: AKI is a frequent complication of critical illness and portends poor outcome. CCL14 is a validated predictor of persistent severe AKI in critically ill patients. We examined the association of CCL14 with urine output within 48 h. Methods: In pooled data from 2 studies of critically ill patients with KDIGO stage 2–3 AKI, CCL14 was measured by NEPHROCLEAR
™ CCL14 Test on the Astute 140® Meter (low, intermediate, and high categories [1.3 and 13 ng/mL]). Average hourly urine output over 48 h, stage 3 AKI per urine output criterion on day 2, and composite of dialysis or death within 7 days were examined using multivariable mixed and logistic regression models. Results: Of the 497 subjects with median age of 65 (56–74) years, 49% (242/497) were on diuretics. CCL14 concentration was low in 219 (44%), intermediate in 217 (44%), and high in 61 (12%) patients. In mixed regression analysis, hourly urine output over time was different within each CCL14 risk category based on diuretic use due to significant three-way interaction (p < 0.001). In logistic regression analysis, CCL14 risk category was independently associated with low urine output on day 2 per KDIGO stage 3 (adjusted for diuretic use and baseline clinical variables), and composite of dialysis or death within 7 days (adjusted for urine output within 48 h of CCL14 measurement). Conclusions: CCL14 measured in patients with moderate to severe AKI is associated with urine output trajectory within 48 h, oliguria on day 2, and dialysis within 7 days. [ABSTRACT FROM AUTHOR]- Published
- 2024
- Full Text
- View/download PDF
38. Standardization of Nomenclature for the Mechanisms and Materials Utilized for Extracorporeal Blood Purification.
- Author
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Reis, Thiago, Ronco, Claudio, Soranno, Danielle E., Clark, William, De Rosa, Silvia, Forni, Lui G., Lorenzin, Anna, Ricci, Zaccaria, Villa, Gianluca, Kellum, John A., Mehta, Ravindra, and Rosner, Mitchell H.
- Subjects
TECHNOLOGICAL innovations ,STANDARDIZATION ,MEMBRANE filters ,REGULATORY approval ,PATIENT safety ,LANGUAGE research - Abstract
In order to develop a standardized nomenclature for the mechanisms and materials utilized during extracorporeal blood purification, a consensus expert conference was convened in November 2022. Standardized nomenclature serves as a common language for reporting research findings, new device development, and education. It is also critically important to support patient safety, allow comparisons between techniques, materials, and devices, and be essential for defining and naming innovative technologies and classifying devices for regulatory approval. The multidisciplinary conference developed detailed descriptions of the performance characteristics of devices (membranes, filters, and sorbents), solute and fluid transport mechanisms, flow parameters, and methods of treatment evaluation. In addition, nomenclature for adsorptive blood purification techniques was proposed. This report summarizes these activities and highlights the need for standardization of nomenclature in the future to harmonize research, education, and innovation in extracorporeal blood purification therapies. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
39. Quality of Care for Acute Kidney Disease: Current Knowledge Gaps and Future Directions
- Author
-
Koyner, Jay L., Liu, Kathleen D., Forni, Lui G., Kashani, Kianoush, Heung, Michael, Wu, Vin-Cent, Kellum, John A., Haase, Michael, Ronco, Claudio, Mehta, Ravi, Mehta, Ravindra L., and Rosner, Mitchell H.
- Published
- 2020
- Full Text
- View/download PDF
40. Fluid Response Evaluation in Sepsis Hypotension and Shock: A Randomized Clinical Trial
- Author
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Douglas, Ivor S., Alapat, Philip M., Corl, Keith A., Exline, Matthew C., Forni, Lui G., Holder, Andre L., Kaufman, David A., Khan, Akram, Levy, Mitchell M., Martin, Gregory S., Sahatjian, Jennifer A., Seeley, Eric, Self, Wesley H., Weingarten, Jeremy A., Williams, Mark, and Hansell, Douglas M.
- Published
- 2020
- Full Text
- View/download PDF
41. Controversies in acute kidney injury: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Conference
- Author
-
Bagshaw, Sean M., Barreto, Erin F., Bihorac, Azra, Bobek, Ilona, Bouchard, Josée, Cerdá, Jorge, Chakravarthi, Rajasekara, De Rosa, Silvia, Engelman, Daniel T., Forni, Lui G., Hemmilä, Ulla K., Herzog, Charles A., Hoste, Eric A., Huen, Sarah C., Iseki, Kunitoshi, Joannidis, Michael, Kashani, Kianoush B., Koyner, Jay L., Kribben, Andreas, Lameire, Norbert, Levey, Andrew S., Macedo, Etienne, Małyszko, Jolanta, Meersch, Melanie, Mehta, Ravindra L., Mewburn, Irene, Mironova, Olga, Murray, Patrick T., Nadim, Mitra K., Pan, Jenny S., Pannu, Neesh, Peng, Zhiyong, Philips, Barbara, Ponce, Daniela, Ray, Patricio E., Ricci, Zaccaria, Rimmelé, Thomas, Ronco, Claudio, Siew, Edward D., Stevens, Paul E., Tolwani, Ashita J., Tonelli, Marcello, Vaara, Suvi T., van Dam, Marjel, Vijayan, Anitha, Wise, Michael, Wu, Vin-Cent, Zarbock, Alexander, Ostermann, Marlies, Bellomo, Rinaldo, Burdmann, Emmanuel A., Doi, Kent, Endre, Zoltan H., Goldstein, Stuart L., Kane-Gill, Sandra L., Liu, Kathleen D., Prowle, John R., Shaw, Andrew D., Srisawat, Nattachai, Cheung, Michael, Jadoul, Michel, Winkelmayer, Wolfgang C., and Kellum, John A.
- Published
- 2020
- Full Text
- View/download PDF
42. Lung-kidney interactions in critically ill patients: consensus report of the Acute Disease Quality Initiative (ADQI) 21 Workgroup
- Author
-
Joannidis, Michael, Forni, Lui G., Klein, Sebastian J., Honore, Patrick M., Kashani, Kianoush, Ostermann, Marlies, and Prowle, John
- Subjects
Baxter Healthcare Corp. ,Medical test kit industry ,Respiratory agents ,Medical equipment and supplies industry ,Medical colleges ,Epidemiology ,Acute disease ,Kidney diseases ,Acute respiratory distress syndrome ,Health care industry - Abstract
Background Multi-organ dysfunction in critical illness is common and frequently involves the lungs and kidneys, often requiring organ support such as invasive mechanical ventilation (IMV), renal replacement therapy (RRT) and/or extracorporeal membrane oxygenation (ECMO). Methods A consensus conference on the spectrum of lung-kidney interactions in critical illness was held under the auspices of the Acute Disease Quality Initiative (ADQI) in Innsbruck, Austria, in June 2018. Through review and critical appraisal of the available evidence, the current state of research, and both clinical and research recommendations were described on the following topics: epidemiology, pathophysiology and strategies to mitigate pulmonary dysfunction among patients with acute kidney injury and/or kidney dysfunction among patients with acute respiratory failure/acute respiratory distress syndrome. Furthermore, emphasis was put on patients receiving organ support (RRT, IMV and/or ECMO) and its impact on lung and kidney function. Conclusion The ADQI 21 conference found significant knowledge gaps about organ crosstalk between lung and kidney and its relevance for critically ill patients. Lung protective ventilation, conservative fluid management and early recognition and treatment of pulmonary infections were the only clinical recommendations with higher quality of evidence. Recommendations for research were formulated, targeting lung-kidney interactions to improve care processes and outcomes in critical illness., Author(s): Michael Joannidis [sup.1], Lui G. Forni [sup.2] [sup.3], Sebastian J. Klein [sup.1] [sup.4], Patrick M. Honore [sup.5], Kianoush Kashani [sup.6], Marlies Ostermann [sup.7], John Prowle [sup.8] [sup.9], Sean M. [...]
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- 2020
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43. The Role of Risk Prediction Models in Prevention and Management of AKI
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Hodgson, Luke E., Selby, Nicholas, Huang, Tao-Min, and Forni, Lui G.
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- 2019
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44. Management of acute kidney injury associated with Covid-19: what have we learned?
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Cottam, Daniel, Nadim, Mitra K., and Forni, Lui G.
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- 2021
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45. Prognostic Biomarkers and AKI: Potential to Enhance the Identification of Post-Operative Patients at Risk of Loss of Renal Function.
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Singh, Rishabh, Watchorn, James C, Zarbock, Alexander, and Forni, Lui G
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PROGNOSIS ,KIDNEY physiology ,ACUTE kidney failure ,CHRONIC kidney failure ,KIDNEY function tests ,KIDNEY transplantation ,NEPHRECTOMY - Abstract
Acute kidney injury (AKI) is a common complication after surgery and the more complex the surgery, the greater the risk. During surgery, patients are exposed to a combination of factors all of which are associated with the development of AKI. These include hypotension and hypovolaemia, sepsis, systemic inflammation, the use of nephrotoxic agents, tissue injury, the infusion of blood or blood products, ischaemia, oxidative stress and reperfusion injury. Given the risks of AKI, it would seem logical to conclude that early identification of patients at risk of AKI would translate into benefit. The conventional markers of AKI, namely serum creatinine and urine output are the mainstay of defining chronic kidney disease but are less suited to the acute phase. Such concerns are compounded in surgical patients given they often have significantly reduced mobility, suboptimal levels of nutrition and reduced muscle bulk. Many patients may also have misleadingly low serum creatinine and high urine output due to aggressive fluid resuscitation, particularly in intensive care units. Over the last two decades, considerable information has accrued with regard to the performance of what was termed "novel" biomarkers of AKI, and here, we discuss the most examined molecules and performance in surgical settings. We also discuss the application of biomarkers to guide patients' postoperative care. Plain Language Summary: Kidney damage is common after major surgery with a recent study showing almost 1 in 5 patients suffer kidney damage. The usual tests for measuring kidney function are excellent in the outpatient but not so good in acute scenario's. Therefore, there has been a lot of interest in new markers of kidney damage (so-called novel biomarkers) which perform well acutely and allow earlier detection of damage allowing treatment to be started earlier. This article summarises the currently available biomarkers for use post-operatively and points out the different information that can be achieved by using them routinely. [ABSTRACT FROM AUTHOR]
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- 2024
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46. New biomarkers in acute kidney injury
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Rossiter, Adam, primary, La, Ashley, additional, Koyner, Jay L., additional, and Forni, Lui G., additional
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- 2023
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47. Designing acute kidney injury clinical trials
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Zarbock, Alexander, primary, Forni, Lui G., additional, Ostermann, Marlies, additional, Ronco, Claudio, additional, Bagshaw, Sean M., additional, Mehta, Ravindra L., additional, Bellomo, Rinaldo, additional, and Kellum, John A., additional
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- 2023
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48. The Janus faces of bicarbonate therapy in the ICU: not sure!
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Forni, Lui G., Hodgson, Luke E., and Selby, Nicholas M.
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- 2020
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49. Pragmatic studies for acute kidney injury: Consensus report of the Acute Disease Quality Initiative (ADQI) 19 Workgroup
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Peng, Zhiyong, Yu, Kaijiang, Ostermann, Marlies, Xi, XiuMing, Hsu, Raymond, Vincent, Jean-Louis, Prowle, John R., Du, Bin, Gallagher, Martin, Wang, Changsong, Murugan, Raghavan, Qiu, Haibo, Rimmelé, Thomas, Li, Jianguo, Forni, Lui G., Kashani, Kianoush, Ronco, Claudio, and Kellum, John A.
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- 2018
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50. Type of Renal Replacement Therapy
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Joannidis, Michael, Forni, Lui G., Oudemans-van Straaten, Heleen M., editor, Forni, Lui G., editor, Groeneveld, A.B. Johan, editor, Bagshaw, Sean M., editor, and Joannidis, Michael, editor
- Published
- 2015
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