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5. Detection and quantification of ergothioneine in human serum using surface enhanced Raman scattering (SERS).

Author

Fornasaro, Stefano, Gotts, Nigel, Venturotti, Gioia, Muelas, Marina Wright, Roberts, Ivayla, Sergo, Valter, Goodacre, Royston, and Bonifacio, Alois

Subjects
*SERS spectroscopy, *ERYTHROCYTES, *LIQUID chromatography-mass spectrometry, *AMINO acids, *AGING prevention
Abstract

Ergothioneine (ERG) is a natural sulfur-containing amino acid found in many organisms, including humans. It accumulates at high concentrations in red blood cells and is distributed to various organs, including the brain. ERG has numerous health benefits and antioxidant capabilities, and it has been linked to various human physiological processes, such as anti-inflammatory, neuroprotective, and anti-aging effects. Accurate, rapid, and cost-effective quantification of ERG levels in human biofluids is crucial for understanding its role in oxidative stress-related diseases. Surface-enhanced Raman scattering (SERS) is an effective approach for measuring compounds at concentrations similar to those at which ERG is present in serum. However, while SERS has been used to characterize or detect ERG, quantification has not yet been achieved due to the variability in the signal enhancement that can arise during sample preparation and analysis. This study introduces a highly efficient and reliable technique for quickly (20 min is typical per sample) measuring ERG levels in human serum using SERS. This employs an internal standard highly specific for ERG which resulted in limit of quantification values of 0.71 μM. To validate this approach, we analysed real human serum with unknown ERG levels as a blind test set and primary reference levels of ERG were produced using a targeted UHPLC-MS/MS reference method. [ABSTRACT FROM AUTHOR]

Published
2025
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6. The Endocannabinoid Activity Remodulation for Psychosis Liability in Youth (EARLY) Study: An Open-Label Feasibility Trial of Ultramicronized-Palmitoylethanolamide Oral Supplementation in Clinical High-Risk State for Psychosis.

Author

Bortoletto, Riccardo, Garzitto, Marco, Piscitelli, Fabiana, Fornasaro, Stefano, Scipioni, Claudia, Sepulcri, Orietta, Fabris, Martina, Curcio, Francesco, Balestrieri, Matteo, and Colizzi, Marco

Subjects
YOUNG adults, DIETARY supplements, PSYCHOSES, MODULATION (Music theory), PSYCHIATRIC drugs
Abstract

To date, no psychotropic medication has shown to effectively halt progression to psychosis among individuals at Clinical High-Risk for psychosis (CHR), fueling the search for novel therapeutic agents. Recent evidence supports Palmitoylethanolamide (PEA) signaling as a potential psychosis biomarker, also indicating a therapeutic role for its supplementation in the treatment of psychotic disorders. Nonetheless, the effect of sustained PEA intake in CHR subjects has never been explored so far. We will assess the feasibility of enrolling 20 CHR young adults presenting with attenuated psychotic symptoms (APS) in a 12-week, open-label, investigator-initiated, proof-of-concept, single-arm trial of ultramicronized-PEA (um-PEA) 600 mg/day. Once completed the 12-week phase, participants will be proposed to enter a 24-week extension phase of the study. We will examine um-PEA ability to reduce APS and psychic distress, um-PEA safety and tolerability, and the biological basis of um-PEA effect in terms of modulation of inflammatory response, endocannabinoid (eCB) signaling, and microbiome composition. Our trial aims to address an unmet clinical need in CHR subjects, providing an initial solid basis for the development of future studies evaluating the efficacy and tolerability of PEA supplementation in this group of patients. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Contributors

Author

Abalde-Cela, Sara, primary, Ali, Akbar, additional, Andreou, Chrysafis, additional, Beleites, Claudia, additional, Bonifacio, Alois, additional, Crawford, Bridget, additional, Czaja, Alexander, additional, Fales, Andrew, additional, Fornasaro, Stefano, additional, Gregoriou, Yiota, additional, Ngo, Hoan Thanh, additional, Pal, Suchetan, additional, Rodríguez-Lorenzo, Laura, additional, Sergo, Valter, additional, Spuch-Calvar, Miguel, additional, Strobbia, Pietro, additional, Vo-Dinh, Tuan, additional, Wang, Hsin-Neng, additional, and Zavaleta, Cristina, additional

Published
2022
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10. Assessing the biobehavioral effects of ultramicronized-palmitoylethanolamide monotherapy in autistic adults with different severity levels: a report of two cases.

Author

Bortoletto, Riccardo, Piscitelli, Fabiana, Basaldella, Marta, Scipioni, Claudia, Comacchio, Carla, Fiorino, Roberta, Fornasaro, Stefano, Barbieri, Pierluigi, Pagliaro, Daniele, Sepulcri, Orietta, Fabris, Martina, Curcio, Francesco, Balestrieri, Matteo, and Colizzi, Marco

Subjects
PSYCHOSOCIAL functioning, AUTISM spectrum disorders, PSYCHOLOGICAL distress, MENTAL depression, TREATMENT effectiveness
Abstract

Despite promise of its supplementation as both monotherapy and add-on treatment in autism spectrum disorder (ASD), the biobehavioral effects of Palmitoylethanolamide (PEA) in autistic adults have never been explored so far. We discussed the cases of two autistic adults with different degrees of severity (level 1 and level 2) presenting with symptoms of psychic distress, who were treated with ultramicronized-PEA (um-PEA) 600 mg/day monotherapy for a sustained period of 4 months. The level 1 autistic patient showed improved depressive symptoms and social engagement at a 12-week follow-up, in parallel to a tendency toward reduced inflammatory response and enhanced endocannabinoid (eCB) signaling, partially relapsing after um-PEA discontinuation at four months. Opposedly, the level 2 autistic patient exhibited a generally stable psychosocial functioning for the initial 12 weeks, consistent with basically unchanged immune and eCBs levels, abruptly deteriorating and leading to antipsychotic initiation afterwards. No significant side effects were reported in both cases during the observation period. The two cases suggest that um-PEA could be an effective option for the treatment of psychic distress in level 1 autistic adults, warranting further investigation of its age- and level-specificity and of the biological underpinnings of its therapeutic effect in ASD. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Biomedical SERS – the current state and future trends.

Author

Cialla-May, Dana, Bonifacio, Alois, Bocklitz, Thomas, Markin, Alexey, Markina, Natalia, Fornasaro, Stefano, Dwivedi, Aradhana, Dib, Tony, Farnesi, Edoardo, Liu, Chen, Ghosh, Arna, and Popp, Juergen

Subjects
SERS spectroscopy, DRUG monitoring, MEDICAL sciences, BODY fluids, COMPLEX matrices
Abstract

Surface enhanced Raman spectroscopy (SERS) is meeting the requirements in biomedical science being a highly sensitive and specific analytical tool. By employing portable Raman systems in combination with customized sample pre-treatment, point-of-care-testing (POCT) becomes feasible. Powerful SERS-active sensing surfaces with high stability and modification layers if required are available for testing and application in complex biological matrices such as body fluids, cells or tissues. This review summarizes the current state in sample collection and pretreatment in SERS detection protocols, SERS detection schemes, i.e. direct and indirect SERS as well as targeted and non-targeted SERS, and SERS-active sensing surfaces. Moreover, the recent developments and advances of SERS in biomedical application scenarios, such as infectious diseases, cancer diagnostics and therapeutic drug monitoring is given, which enables the readers to identify the sample collection and preparation protocols, SERS substrates and detection strategies that are best-suited for their specific applications in biomedicine. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Bioaerosol Sampling Devices and Pretreatment for Bacterial Characterization: Theoretical Differences and a Field Experience in a Wastewater Treatment Plant

Author

Gaetano, Anastasia Serena, primary, Semeraro, Sabrina, additional, Greco, Samuele, additional, Greco, Enrico, additional, Cain, Andrea, additional, Perrone, Maria Grazia, additional, Pallavicini, Alberto, additional, Licen, Sabina, additional, Fornasaro, Stefano, additional, and Barbieri, Pierluigi, additional

Published
2024
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14. Spectroscopic insights into peri-implant mucositis and peri-implantitis: unveiling peri-implant crevicular fluid profiles using surface enhanced Raman scattering

Author

Fornasaro, Stefano, primary, Rapani, Antonio, additional, Farina, Federica, additional, Ibishi, Marigona, additional, Pisnoli, Giulia, additional, Stacchi, Claudio, additional, Sergo, Valter, additional, Bonifacio, Alois, additional, Di Lenarda, Roberto, additional, and Berton, Federico, additional

Published
2024
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15. The Supplementation Therapy in Autism and Response to Treatment (START) Study: An Open-Label Feasibility Trial of Ultramicronized Palmitoylethanolamide Potential to Alleviate Psychic Distress among Autistic Adults.

Author

Bortoletto, Riccardo, Basaldella, Marta, Candolo, Anna, Garzitto, Marco, Comacchio, Carla, Curcio, Francesco, Fabris, Martina, Fornasaro, Stefano, Piscitelli, Fabiana, Sepulcri, Orietta, Balestrieri, Matteo, and Colizzi, Marco

Subjects
AUTISM spectrum disorders, AMIDES, PSYCHOLOGICAL distress, COMMUNICATIVE disorders, MEDICATION safety
Abstract

Autism spectrum disorder (ASD) is a complex neurodevelopmental condition characterized by impaired social communication and restricted or repetitive behavior and interests. Psychic distress is common among individuals with ASD, especially in its milder form (level 1), with anxiety and depression being the most common types. Recent research has identified neuroinflammation and gut dysbiosis as potential neurobiological mechanisms underlying ASD. Palmitoylethanolamide (PEA), an endocannabinoid (eCB)-like compound, has shown promise in modulating such mechanisms and may thus have therapeutic implications for ASD. To date, no clinical trial has evaluated the efficacy of PEA in adults with ASD. This 12-week open-label study will assess the feasibility, tolerability, safety, and efficacy of ultramicronized PEA (um-PEA) in treating symptoms of psychic distress, such as anxiety and depression, in adults with level 1 ASD. Secondary research endpoints will include um-PEA's effects on levels of personal autonomy and neurocognitive and interpersonal function. From a biological point of view, this study will assess um-PEA's effects on inflammatory markers, the metabolic profile, eCB system modulation, and microbial composition as potential mechanisms of action for its therapeutic effect. In conclusion, this study will investigate a novel approach to the treatment of adults presenting with psychic distress in the context of level 1 ASD. The results may provide valuable insight into the use of um-PEA as a treatment option for ASD adults, addressing a significant unmet clinical need. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Self-Organizing Maps: An AI Tool for Identifying Unexpected Source Signatures in Non-Target Screening Analysis of Urban Wastewater by HPLC-HRMS.

Author

Gelao, Vito, Fornasaro, Stefano, Briguglio, Sara C., Mattiussi, Michele, De Martin, Stefano, Astel, Aleksander M., Barbieri, Pierluigi, and Licen, Sabina

Subjects
SELF-organizing maps, SEWAGE disposal plants, INDUSTRIAL wastes, ARTIFICIAL intelligence, OUTLIER detection
Abstract

(1) Background: Monitoring effluent in water treatment plants has a key role in identifying potential pollutants that might be released into the environment. A non-target analysis approach can be used for identifying unknown substances and source-specific multipollutant signatures. (2) Methods: Urban and industrial wastewater effluent were analyzed by HPLC-HRMS for non-target analysis. The anomalous infiltration of industrial wastewater into urban wastewater was investigated by analyzing the mass spectra data of "unknown common" compounds using principal component analysis (PCA) and the Self-Organizing Map (SOM) AI tool. The outcomes of the models were compared. (3) Results: The outlier detection was more straightforward in the SOM model than in the PCA one. The differences among the samples could not be completely perceived in the PCA model. Moreover, since PCA involves the calculation of new variables based on the original experimental ones, it is not possible to reconstruct a chromatogram that displays the recurring patterns in the urban WTP samples. This can be achieved using the SOM outcomes. (4) Conclusions: When comparing a large number of samples, the SOM AI tool is highly efficient in terms of calculation, visualization, and identifying outliers. Interpreting PCA visualization and outlier detection becomes challenging when dealing with a large sample size. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Application of Paper-Based Microfluidic Analytical Devices (µPAD) in Forensic and Clinical Toxicology: A Review

Author

Musile, Giacomo, Grazioli, Cristian, Fornasaro, Stefano, Dossi, Nicolò, De Palo, Elio Franco, Tagliaro, Franco, and Bortolotti, Federica

Subjects
toxicant, drug-facilitated crimes (DFCs), clinical toxicology, microfluidics, illicit drugs, paper-based devices, forensic toxicology, point-of-need (PON) devices, drugs, drug-facilitated sexual assault (DFSA), biosensor
Published
2023

20. Dental Proteomic Analyses and Raman Spectroscopy for the Determination of the Biological Sex and Age of Human Remains from the Greek Cemetery of San Giorgio Extra, Reggio Calabria (Italy)

Author

Greco, Enrico, primary, Gennaro, Andrea Maria, additional, Piombino-Mascali, Dario, additional, Costanzo, Daniela, additional, Accardo, Simona, additional, Licen, Sabina, additional, Barbieri, Pierluigi, additional, Fornasaro, Stefano, additional, Semeraro, Sabrina, additional, Marin, Elia, additional, Signoretti, Sara, additional, Gabriele, Caterina, additional, and Gaspari, Marco, additional

Published
2023
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21. Contributors

Author

Abraham, Soniya, primary, Abramić, Marija, additional, Adnan, Mohammed, additional, Agić, Dejan, additional, Ağrı, İbrahim, additional, Ağrı, Arzu Erdal, additional, Aguiar, Odair, additional, Aiello, Francesca, additional, Allgrove, Judith E, additional, Astiz, Susana, additional, Badolato, Mariateresa, additional, Bakir, Sena, additional, Baliga, Manjeshwar Shrinath, additional, Banerjee, Antara, additional, Banerjee, Anushka, additional, Barnes, Stephen, additional, Bissi, Laura, additional, Bruno, Antonio, additional, Calhau, Conceição, additional, Capanoglu, Esra, additional, Carullo, Gabriele, additional, Celep, Gulcin Sagdicoglu, additional, Christensen, Lars Porskjær, additional, Čvorović, Jovana, additional, D’Archivio, Massimo, additional, D’Cunha, Ritesh, additional, Davison, Glen, additional, D'souza, Reshmina, additional, Elrod, Susan M., additional, Erukainure, Ochuko L., additional, Faria, Ana, additional, Fernandes, Eduarda, additional, Fornasaro, Stefano, additional, Freitas, Marisa, additional, Garcia-Contreras, Consolacion, additional, George, Thomas, additional, Giovannini, Claudio, additional, Gollücke, Andréa Pittelli Boiago, additional, Gonzalez-Bulnes, Antonio, additional, Graier, Wolfgang F., additional, Guo, Honghui, additional, Guo, Tai L., additional, Harlen, Winda Christina, additional, Hölzel, Nadine, additional, Huang, Guannan, additional, Isabel, Beatriz, additional, Shahidul Islam, Md., additional, Jaffe, Russell, additional, Jati, Ignasius Radix A.P., additional, Kamiloglu, Senem, additional, Keating, Elisa, additional, Kent, Katherine, additional, Kesavan, Pallavi, additional, Kojima-Yuasa, Akiko, additional, Madreiter-Sokolowski, Corina T., additional, Mani, Jayashree, additional, Marotta, Francesco, additional, Martel, Fátima, additional, Masella, Roberta, additional, Mathai, Naveen Joseph, additional, Murugesan, Ramachandran, additional, Muscatello, Maria Rosaria Anna, additional, Naik, Taresh Shekar, additional, Özdemir, Doğukan, additional, Özgür, Abdulkadir, additional, Pais, Michael L.J., additional, Palatty, Princy Louis, additional, Passamonti, Sabina, additional, Pathak, Surajit, additional, Peres, Rogério Correa, additional, Popov, O.S., additional, Prasain, Jeevan K., additional, Rao, Suresh, additional, Rastija, Vesna, additional, Ribeiro, Daniel Araki, additional, Ribeiro, Daniela, additional, Saldanha, Elroy, additional, Sanni, Olakunle, additional, Scazzocchio, Beatrice, additional, Shalamay, A.S., additional, Shebeko, S.K., additional, Shimazu, Yoshihito, additional, Shivashankara, Arnadi Ramachandrayya, additional, Silenzi, Annalisa, additional, Simon, Paul, additional, Soumia, Bouzidi, additional, Sujayendra, Davanagere Murali, additional, Swarts, Nigel, additional, Takeda, Mamoru, additional, Takehana, Shiori, additional, Tarasenko, O.O., additional, Tomas, Merve, additional, Tramer, Federica, additional, Vazquez-Gomez, Marta, additional, Vuković, Rosemary, additional, Ward, Wendy E., additional, Michael Wyss, J., additional, Xia, Min, additional, Xu, Joella, additional, Yumol, Jenalyn L., additional, Ziberna, Lovro, additional, Zoccali, Rocco Antonio, additional, and Zupanets, I.A., additional

Published
2018
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23. Data analysis in SERS diagnostics

Author

Fornasaro, Stefano, Beleites, Claudia, Sergo, Valter, Bonifacio, Alois, Andrew Fales, Fornasaro, Stefano, Beleites, Claudia, Sergo, Valter, and Bonifacio, Alois

Subjects
SERS, Data analysis
Abstract

Surface-enhanced Raman spectroscopy (SERS) datasets obtained from biomedical samples are rich in information, but this wealth of information is not always easy to get. Extracting the right information from this complexity is a challenging task. Preprocessing procedures and multivariate analysis methods are extremely powerful tools to help us in this task. These tools, however, are as powerful as dangerous, if not correctly used, and can easily lead to wrong conclusions. This chapter is a short introduction into the analysis and interpretation of SERS spectral data in biomedical studies. The aim is to give practical advices to the researcher through a quick overview of the most relevant techniques for data visualization and analysis, with an emphasis on both their capabilities and weaknesses.

Published
2022

28. Emerging electrochemical methods at the nanointerface: general discussion

Author

Buckingham, Mark A., primary, Cao, Xiangkun Elvis, additional, Chang, Shuai, additional, Chen, Hong-Yuan, additional, Chen, Qianjin, additional, Chinnathambi, Selvaraj, additional, Edwards, Martin A., additional, Fornasaro, Stefano, additional, Gooding, Justin, additional, Hill, Caleb, additional, Hirano-Iwata, Ayumi, additional, Kamali, Ali Reza, additional, Kanoufi, Frédéric, additional, Krause, Steffi, additional, Kurihara, Kazue, additional, Lemay, Serge G., additional, Linfield, Steven, additional, Liu, Xu, additional, Long, Yi-Tao, additional, Lu, Si-Min, additional, Ma, Hui, additional, Mao, Bing-Wei, additional, Meloni, Gabriel N., additional, Menkin, Svetlana, additional, Minteer, Shelley, additional, O’Neill, Shane, additional, Pandey, Popular, additional, Ren, Hang, additional, Slater, Ben, additional, Tian, Zhongqun, additional, Unwin, Patrick, additional, Valavanis, Dimitrios, additional, Walcarius, Alain, additional, Willets, Katherine (Kallie), additional, Wu, Yanfang, additional, Xiao, Li, additional, Xu, Weilin, additional, Yang, Wenrong, additional, Ying, Yi-Lun, additional, and Zhang, Zhu, additional

Published
2022
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29. Electrochemical data mining: from information to knowledge: general discussion

Author

Albrecht, Tim, primary, Cao, Xiangkun Elvis, additional, Chen, Dongfei, additional, Corva, Manuel, additional, Edwards, Martin A., additional, Ewing, Andrew, additional, Fornasaro, Stefano, additional, Gooding, J. Justin, additional, Gundry, Luke, additional, Hirano-Iwata, Ayumi, additional, Jeffcoat, Grant, additional, Kamali, Ali Reza, additional, Kanoufi, Frédéric, additional, Lemay, Serge G., additional, Limani, Ndrina, additional, Linfield, Steven, additional, Liu, Xu, additional, Lu, Si-Min, additional, Meloni, Gabriel N., additional, Tian, Zhongqun, additional, Tschulik, Kristina, additional, Vakamulla Raghu, Swathi Naidu, additional, Wei, Hui, additional, and Ying, Yi-Lun, additional

Published
2022
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32. List of Contributors

Author

Aguiar, Odair, primary, Alkholy, Sarah Omar, additional, Allgrove, Judith, additional, Alqahtani, Samiah Naji, additional, Amini, Anna, additional, de Mello Andrade, Juliana Maria, additional, Andres-Lacueva, Cristina, additional, Aquilato, Andrea, additional, Arora, Rajesh, additional, Arranz, Sara, additional, Ashida, Hitoshi, additional, Avena, Paola, additional, Badole, Sachin L., additional, Baer-Dubowska, Wanda, additional, Bahrim, Gabriela, additional, Baliga, Manjeshwar Shrinath, additional, Barnes, Stephen, additional, Batista, Maria T., additional, Berhanu, Workalemahu Mikre, additional, Bhatia, Alka, additional, Bodhankar, Subhash L., additional, Bodnar, Lubomir, additional, Bolca, Selin, additional, Boto-Ordoñez, Maria, additional, Brizuela, Leyre, additional, Calhau, Conceição, additional, Carluccio, Maria Annunziata, additional, Carrasco-Pozo, Catalina, additional, Caruso, Anna, additional, Casaburi, Ivan, additional, Castro, Gerardo D., additional, Castro, José A., additional, Celep, Gulcin Sagdicoglu, additional, Chacko, Amala, additional, Chaudhari, Swapnil M., additional, Chen, Chung-Hwan, additional, Chen, Lixia, additional, Chiva-Blanch, Gemma, additional, Christensen, Kathrine Bisgaard, additional, Christensen, Lars Porskjær, additional, Chyu, Ming-Chien, additional, Cordova, Felina M., additional, Corona, Giulia, additional, Costa, G., additional, Cress, Brady F., additional, Crozier, Stephen J., additional, Cruz, M.T., additional, Cuvillier, Olivier, additional, Čvorović, Jovana, additional, Cyr, Lisa Danielle, additional, Czank, Charles, additional, D’Archivio, Massimo, additional, Davison, Glen, additional, De Caterina, Raffaele, additional, Deng, Guifang, additional, Devkar, Ranjitsinh V., additional, Doo, Taisha, additional, Doonan, Barbara, additional, Emami, Seyed Ahmad, additional, Estruch, Ramón, additional, Virgili, Fabio, additional, Falk, Michael, additional, Faria, Ana, additional, Farina, Grazia, additional, Fasolo, Daniel, additional, Fayad, Raja, additional, Ferreira, Maria Pontes, additional, Ferri, Claudio, additional, Forester, Sarah C., additional, Fornasaro, Stefano, additional, Cimino, Francesco, additional, Francis, Atul, additional, Francisco, V., additional, Fukuda, Itsuko, additional, Garcia-Aloy, Mar, additional, García-Mediavilla, María Victoria, additional, Gendron, Fidji, additional, Ghantasala, S., additional, Gil-Becerra, David, additional, Giovannini, Claudio, additional, Givigliano, Francesco, additional, Goldstein, Mark R., additional, Goel, Ajay, additional, Gollücke, Andréa Pittelli Boiago, additional, González-Gallego, Javier, additional, Govindaraghavan, Suresh, additional, Grassi, Davide, additional, Gunawardena, Dhanushka, additional, Guo, Honghui, additional, Habauzit, Véronique, additional, Haegeman, Guy, additional, He, Xiran, additional, Hegde, Mahabaleshwar V., additional, Heyninck, Karen, additional, Hsieh, Tze-chen, additional, Hurst, W. Jeffrey, additional, Iemma, Francesca, additional, Igoe, Ann, additional, Iglesias, Jacobo, additional, Ikeda, Ikuo, additional, Jadeja, Ravirajsinh N., additional, Jaffe, Russell, additional, Janda, Elzbieta, additional, Janel, Nathalie, additional, Jangam, Ganesh B., additional, Jayachander, Dipika, additional, Jiang, Fan, additional, Jirillo, Emilio, additional, Joo, Eun Ji, additional, Joseph, Nadhini, additional, Aguiar, Odair, additional, Juturu, Vijaya, additional, Kalekhan, Faizan, additional, Kamath, Krithika, additional, Karana, Rita, additional, Kaur, Kamaljeet, additional, Keating, Elisa, additional, Kennedy, David O., additional, Kerr, Jason, additional, Khaled, Mohd, additional, Khoo, Christina, additional, Khymenets, Olha, additional, Kim, Jiyoung, additional, Kobayashi, Makoto, additional, Kobori, Masuko, additional, Kochikuzhyil, Benson Mathai, additional, Koffas, Mattheos A.G., additional, Korniluk, Jan, additional, Kumar, Ashish, additional, Kumar, G., additional, Kumar, Yashwant, additional, Kumazawa, Yosho, additional, Kurien, Biji T., additional, Kwun, In-Sook, additional, Lambert, Joshua D., additional, Lamuela-Raventos, Rosa Maria, additional, Latheef, Latheesh, additional, Lee, Hyong Joo, additional, Lee, Ki Won, additional, Li, Huabin, additional, Li, Sha, additional, Llorach, Rafael, additional, Lopez, Victoria, additional, Maciel, María E., additional, Magrone, Thea, additional, Mani, Jayashree, additional, Marotta, Francesco, additional, Marquardt, Kristen Conrad, additional, Martel, Fátima, additional, Martínez, Verónica, additional, Maru, Girish B., additional, Mascitelli, Luca, additional, Masella, Roberta, additional, Maskarinec, Gertraud, additional, Massaro, Marika, additional, Masunov, Artëm E., additional, Mathew, Geetha, additional, Medina, Isabel, additional, Medina-Remón, Alexander, additional, Menaa, Abder, additional, Menaa, Bouzid, additional, Menaa, Farid, additional, Miglio, C., additional, Milenkovic, Dragan, additional, Mitjans, Montserrat, additional, Miura, Tomisato, additional, Mo, Huanbiao, additional, Mollace, Vincenzo, additional, Morand, Christine, additional, Moribito, G., additional, Mudgal, Piya Paul, additional, Münch, Gerald, additional, Murakami, Akira, additional, Nagasako-Akazome, Yoko, additional, Nayak, Yogendra, additional, Neves, B.M., additional, Noll, Christophe, additional, Nowak, Renata, additional, Nowacka, Natalia, additional, Odendaal, Antoinette Y., additional, Olech, Marta, additional, Ong, Khang Wei, additional, Osakabe, Naomi, additional, Paluszczak, Jarosław, additional, Parisi, Ortensia Ilaria, additional, Passamonti, Sabina, additional, Patil, Kalyani Y., additional, Pazos, Manuel, additional, Peluso, I., additional, Petry, Nicolai, additional, Pezzi, Vincenzo, additional, Piantanida, Marta, additional, Picci, Nevio, additional, Pimple, Bhushan P., additional, Pinto, John Thomas, additional, Pires, Vanessa Cardoso, additional, Prasain, Jeevan K., additional, Pravettoni, Valerio, additional, Primavesi, Laura, additional, Puoci, Francesco, additional, Quintans, Leandro N., additional, Rabassa, Montse, additional, Rai, Prajwith, additional, Rajeev, Antappa Govindaraju, additional, Rao, Suresh, additional, Rapeanu, Gabriela, additional, Rastmanesh, Reza, additional, Ravi, Rithin, additional, Restuccia, Donatella, additional, Ribeiro, Daniel Araki, additional, Rodrigo, Ramón, additional, Rotches-Ribalta, Maria, additional, Rouhani, Mae Nicole, additional, Saldanha, Elroy, additional, Saija, Antonella, additional, Sánchez-Campos, Sonia, additional, Saxena, Arpit, additional, Scazzocchio, Beatrice, additional, Schauss, Alexander G., additional, Scoditti, Egeria, additional, Scofield, R. Hal, additional, Serafini, Mauro, additional, Sharma, Rakesh, additional, Shen, Chwan-Li, additional, Shende, Pankaj S., additional, Shetty, Vaishaka, additional, Shivashankara, Arnadi Ramachandrayya, additional, Shoji, Toshihiko, additional, Simon, Paul, additional, Sinicropi, Maria Stefania, additional, Smith, Brenda J, additional, Sony, Dargi, additional, Speciale, Antonio, additional, Spencer, Jeremy P.E., additional, Stalmach, Angélique, additional, Stanciuc, Nicoleta, additional, Stover, Mitchel G, additional, Synowiec, Agnieszka, additional, Szarlej-Wcislo, Katarzyna, additional, Tajpara, P., additional, Tan, Benny Kwong Huat, additional, Tao, Ling, additional, Tayarani-Najaran, Nilufar, additional, Tayarani-Najaran, Zahra, additional, Thilakchand, Karadka Ramdas, additional, Tomás-Barberán, Francisco A., additional, Tomás-Navarro, María, additional, Tramer, Federica, additional, Tresserra-Rimbau, Anna, additional, Tréton, Jacques, additional, Tulipani, Sara, additional, Tuñón, María J., additional, Unnikrishnan, Mazhuvancherry K., additional, Urpi-Sarda, Mireia, additional, Valderas-Martínez, Palmira, additional, Vallejo, Fernando, additional, Vauzour, David, additional, Vázquez-Fresno, Rosa, additional, Venkatesh, Ponemone, additional, Veerapur, Veeresh, additional, Vinardell, M. Pilar, additional, Walker, Ross, additional, Watson, Ronald R., additional, Wcislo, Gabriel, additional, Wightman, Emma L., additional, Wilkins, John, additional, Wu, Erxi, additional, Wu, Joseph M, additional, Wu, Shan, additional, Xia, Enqin, additional, Xia, Min, additional, Yajima, Hiroaki, additional, Zanwar, Anand A., additional, and Ziberna, Lovro, additional

Published
2014
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33. Bioavailability of Flavonoids

Author

Ziberna, Lovro, primary, Fornasaro, Stefano, additional, Čvorović, Jovana, additional, Tramer, Federica, additional, and Passamonti, Sabina, additional

Published
2014
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34. 3-Dimensional graphene-like structures and applications: general discussion

Author

Backes, Claudia, primary, Behera, Ranjan Kumar, additional, Bellamy-Carter, Abigail, additional, Bianco, Alberto, additional, Caps, Valérie, additional, Casiraghi, Cinzia, additional, Chhowalla, Manish, additional, Criado, Alejandro, additional, Davies, Trevor, additional, Ferrari, Andrea C., additional, Fornasaro, Stefano, additional, Galembeck, Fernando, additional, Goldie, Stuart, additional, Hersam, Mark C., additional, Kamali, Ali Reza, additional, Kolosov, Vladimir, additional, Kumar, Vimal, additional, Lee, Wai Hin, additional, Martsinovich, Natalia, additional, Melchionna, Michele, additional, Melucci, Manuela, additional, Molle, Alessandro, additional, Morgan, Harry, additional, Neumann, Christof, additional, Nowack, Tim, additional, Oyarzun, Andrea, additional, Palermo, Vincenzo, additional, Papanai, Girija Shankar, additional, Prato, Maurizio, additional, Shin, Yuyoung, additional, Sui, Ruohong, additional, Teixeira, Ivo F., additional, Wang, Gang, additional, and Xia, Zhenyuan, additional

Published
2021
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36. The key role of ergothioneine in label-free surfaceenhanced Raman scattering spectra of biofluids: a retrospective re-assessment of the literature.

Author

Fornasaro, Stefano, Sergo, Valter, and Bonifacio, Alois

Subjects
*RAMAN scattering, *RAMAN spectroscopy, *SERS spectroscopy, *REMANUFACTURING, *AMINO acids
Abstract

Label-free surface-enhanced Raman scattering (SERS) has recently gained attention in the field of liquid biopsy as a rapid and relatively inexpensive technique that could significantly ease clinical diagnosis and prognosis by investigating a biofluid sample with a laser. Indeed, SERS spectra provide information about a set of metabolites present in the analysed biofluid, thereby offering biochemical insight into specific health conditions. Ergothioneine plays a key role since it is one of the few metabolites in biofluids that are detectable by label-free SERS. In the past decade, many studies characterizing biofluids or other biological samples have unknowingly linked this amino acid with crucial metabolic processes, including inflammation, in a plethora of diseases. However, since the SERS spectrum of ergothioneine has been reported only recently, most past studies inadvertently assigned what are now recognized as the spectral features of this compound to other molecules. The purpose of the present review is to summarize and re-evaluate these studies in the light of the recent SERS characterization of ergothioneine so as to better recognize the role of ergothioneine in many clinical conditions. [ABSTRACT FROM AUTHOR]

Published
2022
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37. Surface Enhanced Raman Spectroscopy for Quantitative Analysis: Results of a Large-Scale European Multi-Instrument Interlaboratory Study

Author

Fornasaro, Stefano, Alsamad, Fatima, Baia, Monica, Batista de Carvalho, Luís A.E., Beleites, Claudia, Byrne, Hugh J., Chiadò, Alessandro, Chis, Mihaela, Chisanga, Malama, Daniel, Amuthachelvi, Dybas, Jakub, Eppe, Gauthier, Falgayrac, Guillaume, Faulds, Karen, Gebavi, Hrvoje, Giorgis, Fabrizio, Goodacre, Royston, Graham, Duncan, La Manna, Pietro, Laing, Stacey, Litti, Lucio, Lyng, Fiona M., Malek, Kamilla, Malherbe, Cedric, Marques, Maria P .., Meneghetti, Moreno, Mitri, Elisa, Mohaček-Grošev, Vlasta, Morasso, Carlo, Muhamadali, Howbeer, Musto, Pellegrino, Novara, Chiara, Pannico, Marianna, Penel, Guillaume, Piot, Olivier, Rindzevicius, Tomas, Rusu, Elena A., Schmidt, Michael S., Sergo, Valter, Sockalingum, Ganesh D., Untereiner, Valérie, Vanna, Renzo, Wiercigroch, Ewelina, Bonifacio, Alois, Fornasaro, Stefano, Alsamad, Fatima, Baia, Monica, Batista de Carvalho, Luís A.E., Beleites, Claudia, Byrne, Hugh J., Chiadò, Alessandro, Chis, Mihaela, Chisanga, Malama, Daniel, Amuthachelvi, Dybas, Jakub, Eppe, Gauthier, Falgayrac, Guillaume, Faulds, Karen, Gebavi, Hrvoje, Giorgis, Fabrizio, Goodacre, Royston, Graham, Duncan, La Manna, Pietro, Laing, Stacey, Litti, Lucio, Lyng, Fiona M., Malek, Kamilla, Malherbe, Cedric, Marques, Maria P .., Meneghetti, Moreno, Mitri, Elisa, Mohaček-Grošev, Vlasta, Morasso, Carlo, Muhamadali, Howbeer, Musto, Pellegrino, Novara, Chiara, Pannico, Marianna, Penel, Guillaume, Piot, Olivier, Rindzevicius, Tomas, Rusu, Elena A., Schmidt, Michael S., Sergo, Valter, Sockalingum, Ganesh D., Untereiner, Valérie, Vanna, Renzo, Wiercigroch, Ewelina, and Bonifacio, Alois

Abstract

Surface-enhanced Raman scattering (SERS) is a powerful and sensitive technique for the detection of fingerprint signals of molecules and for the investigation of a series of surface chemical reactions. Many studies introduced quantitative applications of SERS in various fields, and several SERS methods have been implemented for each specific application, ranging in performance characteristics, analytes used, instruments, and analytical matrices. In general, very few methods have been validated according to international guidelines. As a consequence, the application of SERS in highly regulated environments is still considered risky, and the perception of a poorly reproducible and insufficiently robust analytical technique has persistently retarded its routine implementation. Collaborative trials are a type of interlaboratory study (ILS) frequently performed to ascertain the quality of a single analytical method. The idea of an ILS of quantification with SERS arose within the framework of Working Group 1 (WG1) of the EU COST Action BM1401 Raman4Clinics in an effort to overcome the problematic perception of quantitative SERS methods. Here, we report the first interlaboratory SERS study ever conducted, involving 15 laboratories and 44 researchers. In this study, we tried to define a methodology to assess the reproducibility and trueness of a quantitative SERS method and to compare different methods. In our opinion, this is a first important step toward a "standardization" process of SERS protocols, not proposed by a single laboratory but by a larger community.

Published
2020

39. Surface Enhanced Raman Spectroscopy for Quantitative Analysis: Results of a Large-Scale European Multi-Instrument Interlaboratory Study

Author

Fornasaro, Stefano, primary, Alsamad, Fatima, additional, Baia, Monica, additional, Batista de Carvalho, Luís A. E., additional, Beleites, Claudia, additional, Byrne, Hugh J., additional, Chiadò, Alessandro, additional, Chis, Mihaela, additional, Chisanga, Malama, additional, Daniel, Amuthachelvi, additional, Dybas, Jakub, additional, Eppe, Gauthier, additional, Falgayrac, Guillaume, additional, Faulds, Karen, additional, Gebavi, Hrvoje, additional, Giorgis, Fabrizio, additional, Goodacre, Royston, additional, Graham, Duncan, additional, La Manna, Pietro, additional, Laing, Stacey, additional, Litti, Lucio, additional, Lyng, Fiona M., additional, Malek, Kamilla, additional, Malherbe, Cedric, additional, Marques, Maria P. M., additional, Meneghetti, Moreno, additional, Mitri, Elisa, additional, Mohaček-Grošev, Vlasta, additional, Morasso, Carlo, additional, Muhamadali, Howbeer, additional, Musto, Pellegrino, additional, Novara, Chiara, additional, Pannico, Marianna, additional, Penel, Guillaume, additional, Piot, Olivier, additional, Rindzevicius, Tomas, additional, Rusu, Elena A., additional, Schmidt, Michael S., additional, Sergo, Valter, additional, Sockalingum, Ganesh D., additional, Untereiner, Valérie, additional, Vanna, Renzo, additional, Wiercigroch, Ewelina, additional, and Bonifacio, Alois, additional

Published
2020
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40. Bio-inspired optics: general discussion

Author

Clark, Helen, primary, Datta, Bianca, additional, Deravi, Leila, additional, Fiorentino, Carlos, additional, Fornasaro, Stefano, additional, Hardy, Mike, additional, Holt, Amanda, additional, Kuttner, Christian, additional, Mouchet, Sébastien R., additional, Ospina, Laura, additional, Parnell, Andrew, additional, Parton, Thomas G., additional, Paternò, Giuseppe Maria, additional, Potyrailo, Radislav, additional, Qiu, Alex, additional, Rosetta, Giselle, additional, Schenk, Franziska, additional, Schertel, Lukas, additional, Stavenga, Doekele, additional, Steiner, Ullrich, additional, van de Kerkhof, Gea Theodora, additional, Wilts, Bodo, additional, and Xiao, Ming, additional

Published
2020
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43. Sers-based nanosensors for the sensitive detection of reactive oxygen species

Author

Fornasaro, Stefano, Vicario, Annalisa, Ziberna, Lovro, Tramer, Federica, Sergo, Valter, Passamonti, Sabina, Bonifacio, Alois, S. Passamonti, S. Gustincich, T. Lah Turnšek, B. Peterlin, R. Pišot, P. Storici, S. Passamonti, Fornasaro, Stefano, Vicario, Annalisa, Ziberna, Lovro, Tramer, Federica, Sergo, Valter, Passamonti, Sabina, and Bonifacio, Alois

Subjects
antioxidants, SERS, gold nanoparticles, ROS, SERS, gold nanoparticles, antioxidants, ROS
Abstract

The unbalanced production of reactive oxygen species (ROS) and reactive nitrogen species (RNS) has been implicated in the pathogenesis of several human diseases. Indeed, there is great interest in developing methods for measuring quantitatively and selectively the production of ROS/RNS in living cells. Here, we report a simple and sensitive method for the detection of ROS, based on surface-enhanced Raman scattering (SERS) spectroscopy.

Published
2014

44. Red wine consumption: dietary option in the healthy lifestyle modification?

Author

Ziberna, Lovro, Fornasaro, Stefano, Cvorovic, Jovana, Tramer, Federica, Passamonti, Sabina, Ana Petelin, Ziberna, Lovro, Fornasaro, Stefano, Cvorovic, Jovana, Tramer, Federica, and Passamonti, Sabina

Subjects
flavonoids, healthy diet, flavonoids, healthy diet, polyphenols, red wine, red wine, polyphenols
Abstract

Moderate consumption of red wine reduces the risk of cardiovascular, neurodegenerative, cancer, and some other diseases. Among numerous bioactive compounds in the red wine, there is a large group of polyphenols, which are considered to be responsible for the health beneficial activity. They can be divided further into flavonoids (anthocyanins, flavanols, fla‐ vonols) and non‐flavonoids, such as phenolic acids (p‐coumaric, cinnamic, caffeic, gentisic, ferulic, and vanillic acids), and stilbenes (resveratrol). However, red wine consumption ex‐ hibits hormetic responses, thus acting protective at low doses, whereas high doses are detri‐ mental to the human health. Here, we present the rationale for the moderate red wine con‐ sumption as a dietary option in the healthy lifestyle modification.

Published
2014

45. L’INFLUENZA DEGLI ANTOCIANI DEL VINO ROSSO SUL CERVELLO E LE FUNZIONI COGNITIVE

Author

Fornasaro, Stefano, Ziberna, Lovro, Tramer, Federica, Passamonti, Sabina, Simposio AGROTUR, Dr. Klemen Lisjak, Kmetijski inštitut Slovenije, Ljubljana, Slovenia, Fornasaro, Stefano, Ziberna, Lovro, Tramer, Federica, and Passamonti, Sabina

Subjects
polifenoli, antociani, healthy diet, antociani, dieta sana, polifenoli, vino rosso, anthocyanins, healthy diet, polyphenols, red wine, dieta sana, red wine, anthocyanins, vino rosso, polyphenols
Abstract

Moderate consumption of red wine reduces the risk of cardiovascular, neurodegenerative, cancer, and some of the other diseases. Among numerous bioactive compounds in the red wine, the most recent information show that anthocyanins have the most pronounced health protective benefits. Anthocyanins have anti-oxidant, anti-inflammatory, antimicrobial and anti-carcinogenic activities. Here we review the red wine anthocyanins and their bioactivity. Modern dietary guidelines for healthy lifestyle promotion shall include moderate consumption of red wine as an essential part of the daily nutrition.

Published
2014

46. Targeting natural antioxidant compounds to the brain: a metabolomic assessment

Author

Fornasaro, Stefano, Mattivi, Fulvio, Ziberna, Lovro, and Passamonti, Sabina

Subjects
Flavonoids, SERS, Cyanidin 3-glucoside, BIO/10 BIOCHIMICA, Brain, Pharmacokinetic, Metabolomics, Neurodegeneration, SCUOLA DI DOTTORATO DI RICERCA IN NANOTECNOLOGIE, Settore BIO/10 - BIOCHIMICA
Abstract

2013/2014 A diet rich in fruits and vegetables has been associated with a decreased risk of brain diseases. Some plant-specific compounds occurring in fruits and vegetables, such as flavonoids, have been found to exert neuroprotection, thus decreasing neurological disease risk. The current hypothesis is that neuroprotection is due to the antioxidant properties of flavonoids. The main aims of this PhD thesis were: i) to assess whether some flavonoids are transported from the blood into the brain across the blood-brain barrier, ii) to understand if neuroprotection is mediated by an impact on brain metabolism. The first part of the thesis describes in vivo experiments with cyanidin 3-glucoside (C3G), implementing different metabolomics analyses approaches. Mean Time (MT) parameters are reported as useful indicators of the retention properties of C3G in peripheral tissues. The second part deals with the development and characterisation of a selective and sensitive analytical method, based on Surface-Enhanced Raman Spectroscopy (SERS), enabling the assessment of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in living cells. Una dieta ricca in frutta e verdura è stata associata a un ridotto rischio di malattie neurodegenerative, e alcuni composti antiossidanti presenti in frutta e verdura, come i flavonoidi, sono stati riconosciuti come agenti neuroprotettivi. Gli obiettivi principali dell’attività di ricerca riportata in questa tesi sono stati la valutazione del passaggio dal sangue al cervello, attraverso la barriera emato-encefalica, di alcuni flavonoidi, la comprensione del loro impatto sul metabolismo del cervello e del loro meccanismo d'azione come agenti neuroprotettivi. La prima parte della tesi descrive diversi approcci di analisi metabolomica utilizzati in esperimenti in vivo con cianidina 3-glucoside (C3G). Parametri di tempo medio sono riportati come utili indicatori delle proprietà di ritenzione di C3G nei tessuti periferici. La seconda parte presenta lo sviluppo e la caratterizzazione di un metodo analitico, basato sulla spettroscopia Raman amplificata da superfici (SERS), per la determinazione di specie reattive dell’ossigeno e dell’azoto (ROS/RNS), in cellule viventi. XXVII Ciclo 1985

Published
2015

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