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1. Neurologic complications in patients receiving aortic versus subclavian versus femoral arterial cannulation for post-cardiotomy extracorporeal life support: results of the PELS observational multicenter study

Author

Chiarini, Giovanni, Mariani, Silvia, Schaefer, Anne-Kristin, van Bussel, Bas C. T., Di Mauro, Michele, Wiedemann, Dominik, Saeed, Diyar, Pozzi, Matteo, Botta, Luca, Boeken, Udo, Samalavicius, Robertas, Bounader, Karl, Hou, Xiaotong, Bunge, Jeroen J. H., Buscher, Hergen, Salazar, Leonardo, Meyns, Bart, Herr, Daniel, Matteucci, Sacha, Sponga, Sandro, Ramanathan, Kollengode, Russo, Claudio, Formica, Francesco, Sakiyalak, Pranya, Fiore, Antonio, Camboni, Daniele, Raffa, Giuseppe Maria, Diaz, Rodrigo, Wang, I-wen, Jung, Jae-Seung, Belohlavek, Jan, Pellegrino, Vin, Bianchi, Giacomo, Pettinari, Matteo, Barbone, Alessandro, Garcia, José P., Shekar, Kiran, Whitman, Glenn J. R., and Lorusso, Roberto

Published
2024
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2. Features and outcomes of female and male patients requiring postcardiotomy extracorporeal life support

Author

Heuts, Samuel, Conci, Luca, Szalkiewicz, Philipp, Lehmann, Sven, Khalil, Jawad, Obadia, Jean-Francois, Kalampokas, Nikolaos, Jankuviene, Agne, Flecher, Erwan, Reis Miranda, Dinis Dos, Sriranjan, Kogulan, Herr, Daniel, Vedadi, Nazli, Di Eusanio, Marco, MacLaren, Graeme, Ramanathan, Kollengode, Costetti, Alessandro, Schmid, Chistof, Castillo, Roberto, Grus, Tomas, Mikulenka, Vladimir, Solinas, Marco, Mariani, Silvia, Ravaux, Justine Mafalda, van Bussel, Bas C.T., De Piero, Maria Elena, van Kruijk, Sander M.J., Schaefer, Anne-Kristin, Wiedemann, Dominik, Saeed, Diyar, Pozzi, Matteo, Loforte, Antonio, Boeken, Udo, Samalavicius, Robertas, Bounader, Karl, Hou, Xiaotong, Bunge, Jeroen J.H., Buscher, Hergen, Salazar, Leonardo, Meyns, Bart, Mazzeffi, Michael A., Matteucci, Sacha, Sponga, Sandro, Sorokin, Vitaly, Russo, Claudio, Formica, Francesco, Sakiyalak, Pranya, Fiore, Antonio, Camboni, Daniele, Raffa, Giuseppe Maria, Diaz, Rodrigo, Wang, I-wen, Jung, Jae-Seung, Belohlavek, Jan, Pellegrino, Vin, Bianchi, Giacomo, Pettinari, Matteo, Barbone, Alessandro, Garcia, José P., Shekar, Kiran, Whitman, Glenn J.R., and Lorusso, Roberto

Published
2024
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4. Characteristics and Outcomes of Prolonged Venoarterial Extracorporeal Membrane Oxygenation After Cardiac Surgery: The Post-Cardiotomy Extracorporeal Life Support (PELS-1) Cohort Study

Author

Bunge, Jeroen J. H., Mariani, Silvia, Meuwese, Christiaan, van Bussel, Bas C. T., Di Mauro, Michele, Wiedeman, Dominik, Saeed, Diyar, Pozzi, Matteo, Loforte, Antonio, Boeken, Udo, Samalavicius, Robertas, Bounader, Karl, Hou, Xiaotong, Buscher, Hergen, Salazar, Leonardo, Meyns, Bart, Herr, Daniel, Matteucci, Sacha, Sponga, Sandro, MacLaren, Graeme, Russo, Claudio, Formica, Francesco, Sakiyalak, Pranya, Fiore, Antonio, Camboni, Daniele, Raffa, Giuseppe Maria, Diaz, Rodrigo, Wang, I-wen, Jung, Jae-Seung, Belohlavek, Jan, Pellegrino, Vin, Bianchi, Giacomo, Pettinari, Matteo, Barbone, Alessandro, Garcia, José P., Shekar, Kiran, Whitman, Glenn J. R., Gommers, Diederik, Dos Reis Miranda, Dinis, Lorusso, Roberto, Heuts, Samuel, Ravaux, Justine, Schaefer, Anne-Kristin, Conci, Luca, Szalkiewicz, Philipp, Khalil, Jawad, Lehmann, Sven, Obadia, Jean-Francois, Kalampokas, Nikolaos, Jankuviene, Agne, Flecher, Erwan, Sriranjan, Kogulan, Mazzeffi, Michael A, Vedadi, Nazli, Di Eusanio, Marco, Sorokin, Vitaly, Ramanathan, Ram, Costetti, Alessandro, Schmid, Chistof, Castillo, Roberto, Mikulenka, Vladimir, Grus, Tomas, and Solinas, Marco

Published
2024
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9. The importance of timing in postcardiotomy venoarterial extracorporeal membrane oxygenation: A descriptive multicenter observational study

Author

Ravaux, Justine, Schaefer, Ann-Kristin, Conci, Luca, Szalkiewicz, Philipp, Khalil, Jawad, Lehmann, Sven, Obadia, Jean-Francois, Kalampokas, Nikolaos, Flecher, Erwan, Miranda, Dinis Dos Reis, Sriranjan, Kogulan, Mazzeffi, Michael A., Vedadi, Nazli, Di Eusanio, Marco, MacLaren, Graeme, Sorokin, Vitaly, Costetti, Alessandro, Schmid, Chistof, Castillo, Roberto, Mikulenka, Vladimir, Solinas, Marco, Mariani, Silvia, Wang, I-wen, van Bussel, Bas C.T., Heuts, Samuel, Wiedemann, Dominik, Saeed, Diyar, van der Horst, Iwan C.C., Pozzi, Matteo, Loforte, Antonio, Boeken, Udo, Samalavicius, Robertas, Bounader, Karl, Hou, Xiaotong, Bunge, Jeroen J.H., Buscher, Hergen, Salazar, Leonardo, Meyns, Bart, Herr, Daniel, Matteucci, Sacha, Sponga, Sandro, Ramanathan, Kollengode, Russo, Claudio, Formica, Francesco, Sakiyalak, Pranya, Fiore, Antonio, Camboni, Daniele, Raffa, Giuseppe Maria, Diaz, Rodrigo, Jung, Jae-Seung, Belohlavek, Jan, Pellegrino, Vin, Bianchi, Giacomo, Pettinari, Matteo, Barbone, Alessandro, Garcia, José P., Shekar, Kiran, Whitman, Glenn, and Lorusso, Roberto

Published
2023
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10. On-Support and Postweaning Mortality in Postcardiotomy Extracorporeal Membrane Oxygenation

Author

Khalil, Jawad, Lehmann, Sven, Obadia, Jean-Francois, Kalampokas, Nikolaos, Flecher, Erwan, Dos Reis Miranda, Dinis, Sriranjan, Kogulan, Mazzeffi, Michael A., Vedadi, Nazli, Di Eusanio, Marco, Sorokin, Vitaly, Ramanathan, Kollengode, Costetti, Alessandro, Schmid, Chistof, Castillo, Roberto, Mikulenka, Vladimir, Solinas, Marco, Mariani, Silvia, Schaefer, Anne-Kristin, van Bussel, Bas C.T., Di Mauro, Michele, Conci, Luca, Szalkiewicz, Philipp, De Piero, Maria Elena, Heuts, Samuel, Ravaux, Justine, van der Horst, Iwan C.C., Saeed, Diyar, Pozzi, Matteo, Loforte, Antonio, Boeken, Udo, Samalavicius, Robertas, Bounader, Karl, Hou, Xiaotong, Bunge, Jeroen J.H., Buscher, Hergen, Salazar, Leonardo, Meyns, Bart, Herr, Daniel, Matteucci, Sacha, Sponga, Sandro, MacLaren, Graeme, Russo, Claudio, Formica, Francesco, Sakiyalak, Pranya, Fiore, Antonio, Camboni, Daniele, Raffa, Giuseppe Maria, Diaz, Rodrigo, Wang, I-wen, Jung, Jae-Seung, Belohlavek, Jan, Pellegrino, Vin, Bianchi, Giacomo, Pettinari, Matteo, Barbone, Alessandro, Garcia, José P., Whitman, Glenn, Shekar, Kiran, Wiedemann, Dominik, and Lorusso, Roberto

Published
2023
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11. Long-Term Outcomes Comparison Between Surgical and Percutaneous Coronary Revascularization in Patients With Multivessel Coronary Disease or Left Main Disease: A Systematic Review and Study Level Meta-Analysis of Randomized Trials

Author

Formica, Francesco, Gallingani, Alan, Tuttolomondo, Domenico, Hernandez-Vaquero, Daniel, Singh, Gurmeet, Pattuzzi, Claudia, Maestri, Francesco, Niccoli, Giampaolo, Ceccato, Evelina, Lorusso, Roberto, and Nicolini, Francesco

Published
2023
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12. The Relation Between Obesity and Mortality in Postcardiotomy Venoarterial Membrane Oxygenation

Author

Ravaux, Justine, di Mauro, Michele, Schaefer, Ann-Kristin, Conci, Luca, Szalkiewicz, Philipp, Khalil, Jawad, Lehmann, Sven, Obadia, Jean-Francois, Kalampokas, Nikolaos, Flecher, Erwan, Reis Miranda, Dinis Dos, Buscher, Hergen, Herr, Daniel, Vedadi, Nazli, Di Eusanio, Marco, Maclaren, Graeme, Ramanathan, Ram, Costetti, Alessandro, Schmid, Chistof, Castillo, Roberto, Mikulenka, Vladimir, Solinas, Marco, Heuts, Samuel, Mariani, Silvia, van Bussel, Bas C.T., Boeken, Udo, Samalavicius, Robertas, Bounader, Karl, Hou, Xiaotong, Bunge, Jeroen J.H., Sriranjan, Kogulan, Wiedemann, Dominik, Saeed, Diyar, Pozzi, Matteo, Loforte, Antonio, Salazar, Leonardo, Meyns, Bart, Mazzeffi, Michael A., Matteucci, Sacha, Sponga, Sandro, Sorokin, Vitaly, Russo, Claudio, Formica, Francesco, Sakiyalak, Pranya, Fiore, Antonio, Camboni, Daniele, Raffa, Giuseppe Maria, Diaz, Rodrigo, Wang, I-wen, Jung, Jae-Seung, Belohlavek, Jan, Pellegrino, Vin, Bianchi, Giacomo, Pettinari, Matteo, Barbone, Alessandro, Garcia, José P., Shekar, Kiran, Whitman, Glenn, and Lorusso, Roberto

Published
2023
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17. Surgical Treatment of Post-Infarction Left Ventricular Free-Wall Rupture: A Multicenter Study

Author

Matteucci, Matteo, Kowalewski, Mariusz, De Bonis, Michele, Formica, Francesco, Jiritano, Federica, Fina, Dario, Meani, Paolo, Folliguet, Thierry, Bonaros, Nikolaos, Sponga, Sandro, Suwalski, Piotr, De Martino, Andrea, Fischlein, Theodor, Troise, Giovanni, Dato, Guglielmo Actis, Serraino, Giuseppe Filiberto, Shah, Shabir Hussain, Scrofani, Roberto, Antona, Carlo, Fiore, Antonio, Kalisnik, Jurij Matija, D’Alessandro, Stefano, Villa, Emmanuel, Lodo, Vittoria, Colli, Andrea, Aldobayyan, Ibrahim, Massimi, Giulio, Trumello, Cinzia, Beghi, Cesare, and Lorusso, Roberto

Published
2021
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18. Association between cardioplegia and postoperative atrial fibrillation in coronary surgery

Author

Mauro, Michele Di, Calafiore, Antonio M., Di Franco, Antonino, Nicolini, Francesco, Formica, Francesco, Scrofani, Roberto, Antona, Carlo, Messina, Antonio, Troise, Giovanni, Mariscalco, Giovanni, Beghi, Cesare, De Bonis, Michele, Trumello, Cinzia, Miceli, Antonio, Glauber, Mattia, Ranucci, Marco, De Vincentiis, Carlo, Gaudino, Mario, and Lorusso, Roberto

Published
2021
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19. Neurologic complications in patients receiving aortic versus subclavian versus femoral arterial cannulation for post-cardiotomy extracorporeal life support:results of the PELS observational multicenter study

Author

Chiarini, Giovanni, Mariani, Silvia, Schaefer, Anne Kristin, van Bussel, Bas C.T., Di Mauro, Michele, Wiedemann, Dominik, Saeed, Diyar, Pozzi, Matteo, Botta, Luca, Boeken, Udo, Samalavicius, Robertas, Bounader, Karl, Hou, Xiaotong, Bunge, Jeroen J.H., Buscher, Hergen, Salazar, Leonardo, Meyns, Bart, Herr, Daniel, Matteucci, Sacha, Sponga, Sandro, Ramanathan, Kollengode, Russo, Claudio, Formica, Francesco, Sakiyalak, Pranya, Fiore, Antonio, Camboni, Daniele, Raffa, Giuseppe Maria, Diaz, Rodrigo, Wang, I. Wen, Jung, Jae Seung, Belohlavek, Jan, Pellegrino, Vin, Bianchi, Giacomo, Pettinari, Matteo, Barbone, Alessandro, Garcia, José P., Shekar, Kiran, Whitman, Glenn J.R., Lorusso, Roberto, Chiarini, Giovanni, Mariani, Silvia, Schaefer, Anne Kristin, van Bussel, Bas C.T., Di Mauro, Michele, Wiedemann, Dominik, Saeed, Diyar, Pozzi, Matteo, Botta, Luca, Boeken, Udo, Samalavicius, Robertas, Bounader, Karl, Hou, Xiaotong, Bunge, Jeroen J.H., Buscher, Hergen, Salazar, Leonardo, Meyns, Bart, Herr, Daniel, Matteucci, Sacha, Sponga, Sandro, Ramanathan, Kollengode, Russo, Claudio, Formica, Francesco, Sakiyalak, Pranya, Fiore, Antonio, Camboni, Daniele, Raffa, Giuseppe Maria, Diaz, Rodrigo, Wang, I. Wen, Jung, Jae Seung, Belohlavek, Jan, Pellegrino, Vin, Bianchi, Giacomo, Pettinari, Matteo, Barbone, Alessandro, Garcia, José P., Shekar, Kiran, Whitman, Glenn J.R., and Lorusso, Roberto

Abstract

BACKGROUND: Cerebral perfusion may change depending on arterial cannulation site and may affect the incidence of neurologic adverse events in post-cardiotomy extracorporeal life support (ECLS). The current study compares patients' neurologic outcomes with three commonly used arterial cannulation strategies (aortic vs. subclavian/axillary vs. femoral artery) to evaluate if each ECLS configuration is associated with different rates of neurologic complications. METHODS: This retrospective, multicenter (34 centers), observational study included adults requiring post-cardiotomy ECLS between January 2000 and December 2020 present in the Post-Cardiotomy Extracorporeal Life Support (PELS) Study database. Patients with Aortic, Subclavian/Axillary and Femoral cannulation were compared on the incidence of a composite neurological end-point (ischemic stroke, cerebral hemorrhage, brain edema). Secondary outcomes were overall in-hospital mortality, neurologic complications as cause of in-hospital death, and post-operative minor neurologic complications (seizures). Association between cannulation and neurological outcomes were investigated through linear mixed-effects models. RESULTS: This study included 1897 patients comprising 26.5% Aortic (n = 503), 20.9% Subclavian/Axillary (n = 397) and 52.6% Femoral (n = 997) cannulations. The Subclavian/Axillary group featured a more frequent history of hypertension, smoking, diabetes, previous myocardial infarction, dialysis, peripheral artery disease and previous stroke. Neuro-monitoring was used infrequently in all groups. Major neurologic complications were more frequent in Subclavian/Axillary (Aortic: n = 79, 15.8%; Subclavian/Axillary: n = 78, 19.6%; Femoral: n = 118, 11.9%; p < 0.001) also after mixed-effects model adjustment (OR 1.53 [95% CI 1.02-2.31], p = 0.041). Seizures were more common in Subclavian/Axillary (n = 13, 3.4%) than Aortic (n = 9, 1.8%) and Femoral cannul

Published
2024

20. Sex-Related Differences in Life Expectancy Compared to General Population after Surgery for Ascending Aortic Aneurysm.

Author

Almendárez, Marcel, Formica, Francesco, Gutierrez Sáenz de Santamaría, Jorge, Avanzas, Pablo, Escalera, Alain, Alvarez-Velasco, Rut, Pascual, Isaac, Silva, Jacobo, Díaz, Rocío, Alperi, Alberto, and Hernández-Vaquero, Daniel

Subjects
*ASCENDING aorta aneurysms, *POSTOPERATIVE period, *LIFE expectancy, *POPULATION aging, MORTALITY risk factors
Abstract

Background/Objectives: Understanding sex-based differences in cardiovascular outcomes is paramount to improving clinical outcomes. Surgery is an aggressive but effective therapy for ascending aortic aneurysm. We sought to determine if being a woman is a risk factor for long-term mortality after this surgery. We compared their life expectancy with a general population of the same age, sex, year, and region. Methods: We compared men and women undergoing AAA surgery at our institution from 2000 to 2019. After balancing the population with propensity score (PS) matching, we compared long-term mortality control with a Cox regression. We determined the RS using the Ederer II method and compared it to a healthy reference population of the same age, sex, and region. Results: From 2000 to 2019, 232 women and 506 men underwent ascending aortic aneurysm surgery. After a mean follow-up of 51.5 ± 34.5 months, sex was not an independent risk factor for long-term mortality in the multivariable analysis [HR: 0.68 (95% CI 0.43–1.07, p = 0.23)]. Matching by baseline characteristics, 196 pairs were analyzed with no differences regarding mortality in the Cox regression [HR: 1.11 (95% CI 0.65–1.9, p = 0.23)]. Men and women who survived the postoperative period presented a relative survival of 100.3% (95% CI 97.4–101%) and 100.3% (95% CI 98.9–101.1%), respectively, similar to the reference population without the disease. Conclusions: For patients undergoing AAA surgery, sex was not an independent predictor of mortality. Men and women who survived the postoperative period presented a similar life expectancy to that of the reference population (people free from the disease of the same age, sex, year, and region). [ABSTRACT FROM AUTHOR]

Published
2024
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21. Cardiovascular Disease from Pathophysiology to Risk Estimation: Is Inflammation Estimated through Perivascular Attenuation on Computed Tomography the Key?

Author

Tuttolomondo, Domenico, primary, Niccoli, Giampaolo, additional, Martini, Chiara, additional, D’Ascenzo, Fabrizio, additional, De Filippo, Ovidio, additional, Nicolini, Francesco, additional, Formica, Francesco, additional, Carino, Davide, additional, Gurgoglione, Filippo Luca, additional, Denegri, Andrea, additional, Magnani, Giulia, additional, Vignali, Luigi, additional, De Filippo, Massimo, additional, Sverzellati, Nicola, additional, Ticinesi, Andrea, additional, Bergamaschi, Luca, additional, Pizzi, Carmine, additional, Gherbesi, Elisa, additional, Suma, Sergio, additional, and Gaibazzi, Nicola, additional

Published
2024
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26. The importance of timing in postcardiotomy venoarterial extracorporeal membrane oxygenation: A descriptive multicenter observational study

Author

Mariani, Silvia, primary, Wang, I-wen, additional, van Bussel, Bas C.T., additional, Heuts, Samuel, additional, Wiedemann, Dominik, additional, Saeed, Diyar, additional, van der Horst, Iwan C.C., additional, Pozzi, Matteo, additional, Loforte, Antonio, additional, Boeken, Udo, additional, Samalavicius, Robertas, additional, Bounader, Karl, additional, Hou, Xiaotong, additional, Bunge, Jeroen J.H., additional, Buscher, Hergen, additional, Salazar, Leonardo, additional, Meyns, Bart, additional, Herr, Daniel, additional, Matteucci, Sacha, additional, Sponga, Sandro, additional, Ramanathan, Kollengode, additional, Russo, Claudio, additional, Formica, Francesco, additional, Sakiyalak, Pranya, additional, Fiore, Antonio, additional, Camboni, Daniele, additional, Raffa, Giuseppe Maria, additional, Diaz, Rodrigo, additional, Jung, Jae-Seung, additional, Belohlavek, Jan, additional, Pellegrino, Vin, additional, Bianchi, Giacomo, additional, Pettinari, Matteo, additional, Barbone, Alessandro, additional, Garcia, José P., additional, Shekar, Kiran, additional, Whitman, Glenn, additional, Lorusso, Roberto, additional, Ravaux, Justine, additional, Schaefer, Ann-Kristin, additional, Conci, Luca, additional, Szalkiewicz, Philipp, additional, Khalil, Jawad, additional, Lehmann, Sven, additional, Obadia, Jean-Francois, additional, Kalampokas, Nikolaos, additional, Flecher, Erwan, additional, Miranda, Dinis Dos Reis, additional, Sriranjan, Kogulan, additional, Mazzeffi, Michael A., additional, Vedadi, Nazli, additional, Di Eusanio, Marco, additional, MacLaren, Graeme, additional, Sorokin, Vitaly, additional, Costetti, Alessandro, additional, Schmid, Chistof, additional, Castillo, Roberto, additional, Mikulenka, Vladimir, additional, and Solinas, Marco, additional

Published
2023
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27. Resultados tras 5 años de cirugía o abordaje percutáneo en coronariopatía grave. Metanálisis de ensayos aleatorizados con reconstrucción del tiempo hasta el evento

Author

Formica, Francesco, primary, Hernandez-Vaquero, Daniel, additional, Tuttolomondo, Domenico, additional, Gallingani, Alan, additional, Singh, Gurmeet, additional, Pattuzzi, Claudia, additional, Niccoli, Giampaolo, additional, Lorusso, Roberto, additional, and Nicolini, Francesco, additional

Published
2023
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28. On-Support and Postweaning Mortality in Postcardiotomy Extracorporeal Membrane Oxygenation

Author

Mariani, Silvia, primary, Schaefer, Anne-Kristin, additional, van Bussel, Bas C.T., additional, Di Mauro, Michele, additional, Conci, Luca, additional, Szalkiewicz, Philipp, additional, De Piero, Maria Elena, additional, Heuts, Samuel, additional, Ravaux, Justine, additional, van der Horst, Iwan C.C., additional, Saeed, Diyar, additional, Pozzi, Matteo, additional, Loforte, Antonio, additional, Boeken, Udo, additional, Samalavicius, Robertas, additional, Bounader, Karl, additional, Hou, Xiaotong, additional, Bunge, Jeroen J.H., additional, Buscher, Hergen, additional, Salazar, Leonardo, additional, Meyns, Bart, additional, Herr, Daniel, additional, Matteucci, Sacha, additional, Sponga, Sandro, additional, MacLaren, Graeme, additional, Russo, Claudio, additional, Formica, Francesco, additional, Sakiyalak, Pranya, additional, Fiore, Antonio, additional, Camboni, Daniele, additional, Raffa, Giuseppe Maria, additional, Diaz, Rodrigo, additional, Wang, I-wen, additional, Jung, Jae-Seung, additional, Belohlavek, Jan, additional, Pellegrino, Vin, additional, Bianchi, Giacomo, additional, Pettinari, Matteo, additional, Barbone, Alessandro, additional, Garcia, José P., additional, Whitman, Glenn, additional, Shekar, Kiran, additional, Wiedemann, Dominik, additional, Lorusso, Roberto, additional, Khalil, Jawad, additional, Lehmann, Sven, additional, Obadia, Jean-Francois, additional, Kalampokas, Nikolaos, additional, Flecher, Erwan, additional, Dos Reis Miranda, Dinis, additional, Sriranjan, Kogulan, additional, Mazzeffi, Michael A., additional, Vedadi, Nazli, additional, Di Eusanio, Marco, additional, Sorokin, Vitaly, additional, Ramanathan, Kollengode, additional, Costetti, Alessandro, additional, Schmid, Chistof, additional, Castillo, Roberto, additional, Mikulenka, Vladimir, additional, and Solinas, Marco, additional

Published
2023
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31. Patient and Management Variables Associated With Survival After Postcardiotomy Extracorporeal Membrane Oxygenation in Adults: The PELS‐1 Multicenter Cohort Study

Author

Mariani, Silvia, primary, Heuts, Samuel, additional, van Bussel, Bas C. T., additional, Di Mauro, Michele, additional, Wiedemann, Dominik, additional, Saeed, Diyar, additional, Pozzi, Matteo, additional, Loforte, Antonio, additional, Boeken, Udo, additional, Samalavicius, Robertas, additional, Bounader, Karl, additional, Hou, Xiaotong, additional, Bunge, Jeroen J. H., additional, Buscher, Hergen, additional, Salazar, Leonardo, additional, Meyns, Bart, additional, Herr, Daniel, additional, Matteucci, Marco L. Sacha, additional, Sponga, Sandro, additional, MacLaren, Graeme, additional, Russo, Claudio, additional, Formica, Francesco, additional, Sakiyalak, Pranya, additional, Fiore, Antonio, additional, Camboni, Daniele, additional, Raffa, Giuseppe Maria, additional, Diaz, Rodrigo, additional, Wang, I‐wen, additional, Jung, Jae‐Seung, additional, Belohlavek, Jan, additional, Pellegrino, Vin, additional, Bianchi, Giacomo, additional, Pettinari, Matteo, additional, Barbone, Alessandro, additional, Garcia, José P., additional, Shekar, Kiran, additional, Whitman, Glenn J. R., additional, Lorusso, Roberto, additional, Ravaux, Justine, additional, Schaefer, Anne‐Kristin, additional, Conci, Luca, additional, Szalkiewicz, Philipp, additional, Khalil, Jawad, additional, Lehmann, Sven, additional, Obadia, Jean‐Francois, additional, Kalampokas, Nikolaos, additional, Flecher, Erwan, additional, Miranda, Dinis Dos Reis, additional, Sriranjan, Kogulan, additional, Mazzeffi, Michael A., additional, Vedadi, Nazli, additional, Di Eusanio, Marco, additional, Sorokin, Vitaly, additional, Ramanathan, Kollengode, additional, Costetti, Alessandro, additional, Schmid, Chistof, additional, Castillo, Roberto, additional, Mikulenka, Vladimir, additional, and Solinas, Marco, additional

Published
2023
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32. The Relation Between Obesity and Mortality in Postcardiotomy Venoarterial Membrane Oxygenation

Author

Heuts, Samuel, primary, Mariani, Silvia, additional, van Bussel, Bas C.T., additional, Boeken, Udo, additional, Samalavicius, Robertas, additional, Bounader, Karl, additional, Hou, Xiaotong, additional, Bunge, Jeroen J.H., additional, Sriranjan, Kogulan, additional, Wiedemann, Dominik, additional, Saeed, Diyar, additional, Pozzi, Matteo, additional, Loforte, Antonio, additional, Salazar, Leonardo, additional, Meyns, Bart, additional, Mazzeffi, Michael A., additional, Matteucci, Sacha, additional, Sponga, Sandro, additional, Sorokin, Vitaly, additional, Russo, Claudio, additional, Formica, Francesco, additional, Sakiyalak, Pranya, additional, Fiore, Antonio, additional, Camboni, Daniele, additional, Raffa, Giuseppe Maria, additional, Diaz, Rodrigo, additional, Wang, I-wen, additional, Jung, Jae-Seung, additional, Belohlavek, Jan, additional, Pellegrino, Vin, additional, Bianchi, Giacomo, additional, Pettinari, Matteo, additional, Barbone, Alessandro, additional, Garcia, José P., additional, Shekar, Kiran, additional, Whitman, Glenn, additional, Lorusso, Roberto, additional, Ravaux, Justine, additional, di Mauro, Michele, additional, Schaefer, Ann-Kristin, additional, Conci, Luca, additional, Szalkiewicz, Philipp, additional, Khalil, Jawad, additional, Lehmann, Sven, additional, Obadia, Jean-Francois, additional, Kalampokas, Nikolaos, additional, Flecher, Erwan, additional, Reis Miranda, Dinis Dos, additional, Buscher, Hergen, additional, Herr, Daniel, additional, Vedadi, Nazli, additional, Di Eusanio, Marco, additional, Maclaren, Graeme, additional, Ramanathan, Ram, additional, Costetti, Alessandro, additional, Schmid, Chistof, additional, Castillo, Roberto, additional, Mikulenka, Vladimir, additional, and Solinas, Marco, additional

Published
2023
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34. Extracorporeal life support in mitral papillary muscle rupture: outcome of Multicenter Study

Author

Massimi, Giulio, primary, Matteucci, Matteo, additional, De Bonis, Michele, additional, Kowalewski, Mariusz, additional, Formica, Francesco, additional, Russo, Claudio Francesco, additional, Sponga, Sandro, additional, Vendramin, Ivan, additional, Colli, Andrea, additional, Falcetta, Giosuè, additional, Trumello, Cinzia, additional, Carrozzini, Massimiliano, additional, Fischlein, Theodor, additional, Troise, Giovanni, additional, Dato, Guglielmo Actis, additional, D’Alessandro, Stefano, additional, Nia, Peyman Sardari, additional, Lodo, Vittoria, additional, Villa, Emmanuel, additional, Shah, Shabir Hussain, additional, Scrofani, Roberto, additional, Binaco, Irene, additional, Kalisnik, Jurij Matija, additional, Pettinari, Matteo, additional, Thielmann, Matthias, additional, Meyns, Bart, additional, Khouqeer, Fareed A., additional, Fino, Carlo, additional, Simon, Caterina, additional, Severgnini, Paolo, additional, Kowalowka, Adam, additional, Deja, Marek A., additional, Ronco, Daniele, additional, and Lorusso, Roberto, additional

Published
2023
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35. Patient and Management Variables Associated With Survival After Postcardiotomy Extracorporeal Membrane Oxygenation in Adults:The PELS-1 Multicenter Cohort Study

Author

Mariani, Silvia, Heuts, Samuel, van Bussel, Bas C.T., Di Mauro, Michele, Wiedemann, Dominik, Saeed, Diyar, Pozzi, Matteo, Loforte, Antonio, Boeken, Udo, Samalavicius, Robertas, Bounader, Karl, Hou, Xiaotong, Bunge, Jeroen J.H., Buscher, Hergen, Salazar, Leonardo, Meyns, Bart, Herr, Daniel, Matteucci, Marco L.Sacha, Sponga, Sandro, MacLaren, Graeme, Russo, Claudio, Formica, Francesco, Sakiyalak, Pranya, Fiore, Antonio, Camboni, Daniele, Raffa, Giuseppe Maria, Diaz, Rodrigo, Wang, I. Wen, Jung, Jae Seung, Belohlavek, Jan, Pellegrino, Vin, Bianchi, Giacomo, Pettinari, Matteo, Barbone, Alessandro, Garcia, José P., Shekar, Kiran, Whitman, Glenn J.R., Lorusso, Roberto, Mariani, Silvia, Heuts, Samuel, van Bussel, Bas C.T., Di Mauro, Michele, Wiedemann, Dominik, Saeed, Diyar, Pozzi, Matteo, Loforte, Antonio, Boeken, Udo, Samalavicius, Robertas, Bounader, Karl, Hou, Xiaotong, Bunge, Jeroen J.H., Buscher, Hergen, Salazar, Leonardo, Meyns, Bart, Herr, Daniel, Matteucci, Marco L.Sacha, Sponga, Sandro, MacLaren, Graeme, Russo, Claudio, Formica, Francesco, Sakiyalak, Pranya, Fiore, Antonio, Camboni, Daniele, Raffa, Giuseppe Maria, Diaz, Rodrigo, Wang, I. Wen, Jung, Jae Seung, Belohlavek, Jan, Pellegrino, Vin, Bianchi, Giacomo, Pettinari, Matteo, Barbone, Alessandro, Garcia, José P., Shekar, Kiran, Whitman, Glenn J.R., and Lorusso, Roberto

Abstract

Background Extracorporeal membrane oxygenation (ECMO) has been increasingly used for postcardiotomy cardiogenic shock, but without a concomitant reduction in observed in-hospital mortality. Long-term outcomes are unknown. This study describes patients' characteristics, in-hospital outcome, and 10-year survival after postcardiotomy ECMO. Variables associated with in-hospital and postdischarge mortality are investigated and reported. Methods and Results The retrospective international multicenter observational PELS-1 (Postcardiotomy Extracorporeal Life Support) study includes data on adults requiring ECMO for postcardiotomy cardiogenic shock between 2000 and 2020 from 34 centers. Variables associated with mortality were estimated preoperatively, intraoperatively, during ECMO, and after the occurrence of any complications, and then analyzed at different time points during a patient's clinical course, through mixed Cox proportional hazards models containing fixed and random effects. Follow-up was established by institutional chart review or contacting patients. This analysis included 2058 patients (59% were men; median [interquartile range] age, 65.0 [55.0-72.0] years). In-hospital mortality was 60.5%. Independent variables associated with in-hospital mortality were age (hazard ratio [HR], 1.02 [95% CI, 1.01-1.02]) and preoperative cardiac arrest (HR, 1.41 [95% CI, 1.15-1.73]). In the subgroup of hospital survivors, the overall 1-, 2-, 5-, and 10-year survival rates were 89.5% (95% CI, 87.0%-92.0%), 85.4% (95% CI, 82.5%-88.3%), 76.4% (95% CI, 72.5%-80.5%), and 65.9% (95% CI, 60.3%-72.0%), respectively. Variables associated with postdischarge mortality included older age, atrial fibrillation, emergency surgery, type of surgery, postoperative acute kidney injury, and postoperative septic shock. Conclusions In adults, in-hospital mortality after postcardiotomy ECMO remains high; however, two-thirds of those who are discharged from hospital survive up to 10 years. Patien

Published
2023

36. Heterogeneity in clinical practices for post-cardiotomy extracorporeal life support:A pilot survey from the PELS-1 multicenter study

Author

Mariani, Silvia, Bari, Gabor, Ravaux, Justine M., van Bussel, Bas C.T., De Piero, Maria Elena, Schaefer, Ann Kristin, Jawad, Khalil, Pozzi, Matteo, Loforte, Antonio, Kalampokas, Nikolaos, Jankuviene, Agne, Flecher, Erwan, Hou, Xiaotong, Bunge, Jeroen J.H., Sriranjan, Kogulan, Salazar, Leonardo, Meyns, Bart, Mazzeffi, Michael A., Matteucci, Sacha, Sponga, Sandro, Ramanathan, Kollengode, Costetti, Alessandro, Formica, Francesco, Sakiyalak, Pranya, Fiore, Antonio, Schmid, Chistof, Raffa, Giuseppe Maria, Castillo, Roberto, Wang, I. wen, Jung, Jae Seung, Grus, Tomas, Pellegrino, Vin, Bianchi, Giacomo, Pettinari, Matteo, Barbone, Alessandro, Garcia, José P., Kowalewski, Mariusz, Shekar, Kiran, Whitman, Glenn, Lorusso, Roberto, Mariani, Silvia, Bari, Gabor, Ravaux, Justine M., van Bussel, Bas C.T., De Piero, Maria Elena, Schaefer, Ann Kristin, Jawad, Khalil, Pozzi, Matteo, Loforte, Antonio, Kalampokas, Nikolaos, Jankuviene, Agne, Flecher, Erwan, Hou, Xiaotong, Bunge, Jeroen J.H., Sriranjan, Kogulan, Salazar, Leonardo, Meyns, Bart, Mazzeffi, Michael A., Matteucci, Sacha, Sponga, Sandro, Ramanathan, Kollengode, Costetti, Alessandro, Formica, Francesco, Sakiyalak, Pranya, Fiore, Antonio, Schmid, Chistof, Raffa, Giuseppe Maria, Castillo, Roberto, Wang, I. wen, Jung, Jae Seung, Grus, Tomas, Pellegrino, Vin, Bianchi, Giacomo, Pettinari, Matteo, Barbone, Alessandro, Garcia, José P., Kowalewski, Mariusz, Shekar, Kiran, Whitman, Glenn, and Lorusso, Roberto

Abstract

Background:High-quality evidence for post-cardiotomy extracorporeal life support (PC-ECLS) management is lacking. This study investigated real-world PC-ECLS clinical practices. Methods: This cross-sectional, multi-institutional, international pilot survey explored center organization, anticoagulation management, left ventricular unloading, distal limb perfusion, PC-ECLS monitoring, and transfusion practices. Twenty-nine questions were distributed among 34 hospitals participating in the Post-cardiotomy Extra-Corporeal Life Support Study. Results: Of the 32 centers [16 low-volume (50%); 16 high-volume (50%)] that responded, 16 (50%) had dedicated ECLS specialists. Twenty-six centers (81.3%) reported using additional mechanical circulatory supports. Anticoagulation practices were highly heterogeneous: 24 hospitals (75%) reported using patients bleeding status as a guide, without a specific threshold in 54.2% of cases. Transfusion targets ranged from 7 to 10 g/dL. Most centers used cardiac venting on a case-by-case basis (78.1%) and regular distal limb perfusion (84.4%). Nineteen (54.9%) centers reported dedicated monitoring protocols, including daily echocardiography (87.5%), Swan-Ganz catheterization (40.6%), cerebral near-infrared spectroscopy (53.1%), and multimodal assessment of limb ischemia. Inspection of the circuit (71.9%), oxygenator pressure drop (68.8%), plasma free hemoglobin (75%), d-dimer (59.4%), lactate dehydrogenase (56.3%), and fibrinogen (46.9%) are used to diagnose hemolysis and thrombosis. Conclusions: This study shows remarkable heterogeneity in clinical practices for PC-ECLS management. More standardized protocols and better implementation of the available evidence are recommended.

Published
2023

37. The importance of timing in postcardiotomy venoarterial extracorporeal membrane oxygenation:A descriptive multicenter observational study

Author

Mariani, Silvia, Wang, I. wen, van Bussel, Bas C.T., Heuts, Samuel, Wiedemann, Dominik, Saeed, Diyar, van der Horst, Iwan C.C., Pozzi, Matteo, Loforte, Antonio, Boeken, Udo, Samalavicius, Robertas, Bounader, Karl, Hou, Xiaotong, Bunge, Jeroen J.H., Buscher, Hergen, Salazar, Leonardo, Meyns, Bart, Herr, Daniel, Matteucci, Sacha, Sponga, Sandro, Ramanathan, Kollengode, Russo, Claudio, Formica, Francesco, Sakiyalak, Pranya, Fiore, Antonio, Camboni, Daniele, Raffa, Giuseppe Maria, Diaz, Rodrigo, Jung, Jae Seung, Belohlavek, Jan, Pellegrino, Vin, Bianchi, Giacomo, Pettinari, Matteo, Barbone, Alessandro, Garcia, José P., Shekar, Kiran, Whitman, Glenn, Lorusso, Roberto, Miranda, Dinis Dos Reis, Mariani, Silvia, Wang, I. wen, van Bussel, Bas C.T., Heuts, Samuel, Wiedemann, Dominik, Saeed, Diyar, van der Horst, Iwan C.C., Pozzi, Matteo, Loforte, Antonio, Boeken, Udo, Samalavicius, Robertas, Bounader, Karl, Hou, Xiaotong, Bunge, Jeroen J.H., Buscher, Hergen, Salazar, Leonardo, Meyns, Bart, Herr, Daniel, Matteucci, Sacha, Sponga, Sandro, Ramanathan, Kollengode, Russo, Claudio, Formica, Francesco, Sakiyalak, Pranya, Fiore, Antonio, Camboni, Daniele, Raffa, Giuseppe Maria, Diaz, Rodrigo, Jung, Jae Seung, Belohlavek, Jan, Pellegrino, Vin, Bianchi, Giacomo, Pettinari, Matteo, Barbone, Alessandro, Garcia, José P., Shekar, Kiran, Whitman, Glenn, Lorusso, Roberto, and Miranda, Dinis Dos Reis

Abstract

Objectives: Postcardiotomy extracorporeal membrane oxygenation (ECMO) can be initiated intraoperatively or postoperatively based on indications, settings, patient profile, and conditions. The topic of implantation timing only recently gained attention from the clinical community. We compare patient characteristics as well as in-hospital and long-term survival between intraoperative and postoperative ECMO.Methods: The retrospective, multicenter, observational Postcardiotomy Extracorporeal Life Support (PELS-1) study includes adults who required ECMO due to postcardiotomy shock between 2000 and 2020. We compared patients who received ECMO in the operating theater (intraoperative) with those in the intensive care unit (postoperative) on in-hospital and postdischarge outcomes. Results: We studied 2003 patients (women: 41.1%; median age: 65 years; interquartile range [IQR], 55.0-72.0). Intraoperative ECMO patients (n = 1287) compared with postoperative ECMO patients (n = 716) had worse preoperative risk profiles. Cardiogenic shock (45.3%), right ventricular failure (15.9%), and cardiac arrest (14.3%) were the main indications for postoperative ECMO initiation, with cannulation occurring after (median) 1 day (IQR, 1-3 days). Compared with intraoperative application, patients who received postoperative ECMO showed more complications, cardiac reoperations (intraoperative: 19.7%; postoperative: 24.8%, P = .011), percutaneous coronary interventions (intraoperative: 1.8%; postoperative: 3.6%, P = .026), and had greater in-hospital mortality (intraoperative: 57.5%; postoperative: 64.5%, P = .002). Among hospital survivors, ECMO duration was shorter after intraoperative ECMO (median, 104; IQR, 67.8-164.2 hours) compared with postoperative ECMO (median, 139.7; IQR, 95.8-192 hours, P < .001), whereas postdischarge long-term survival was similar between the 2 groups (P = .86). Conclusions: Intraopera

Published
2023

42. Surgical and percutaneous coronary revascularization in patients with multivessel or left main disease; what happens beyond five years? A systematic review and study level meta-analysis of randomized trials.

Author

Formica, Francesco, primary, Hernandez-Vaquero, Daniel, additional, Tuttolomondo, Domenico, additional, Gallingani, Alan, additional, singh, gurmeet, additional, Pattuzzi, Claudia, additional, Niccoli, Giampaolo, additional, Lorusso, Roberto, additional, and Nicolini, Francesco, additional

Published
2023
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44. Redo Surgical Aortic Valve Replacement versus Valve-In-Valve Transcatheter Aortic Valve Implantation: A Systematic Review and Reconstructed Time-To-Event Meta-Analysis

Author

Formica, Francesco, primary, Gallingani, Alan, additional, Tuttolomondo, Domenico, additional, Hernandez-Vaquero, Daniel, additional, D’Alessandro, Stefano, additional, Pattuzzi, Claudia, additional, Çelik, Mevlüt, additional, Singh, Gurmeet, additional, Ceccato, Evelina, additional, Niccoli, Giampaolo, additional, Lorusso, Roberto, additional, and Nicolini, Francesco, additional

Published
2023
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