63,116 results on '"Forman, A."'
Search Results
2. The Arpu Kuilpu Meteorite: In-depth characterization of an H5 chondrite delivered from a Jupiter Family Comet orbit
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Anderson, Seamus L., Benedix, Gretchen K., Godel, Belinda, Alosius, Romain M. L., Krietsch, Daniela, Busemann, Henner, Maden, Colin, Friedrich, Jon M., McMonigal, Lara R., Welten, Kees C., Caffee, Marc W., Macke, Robert J., Cadogan, Seán, Ryan, Dominic H., Jourdan, Fred, Mayers, Celia, Laubenstein, Matthias, Greenwood, Richard C., Roberts, Malcom P., Devillepoix, Hadrien A. R., Sansom, Eleanor K., Towner, Martin C., Cupák, Martin, Bland, Philip A., Forman, Lucy V., Fairweather, John H., Rogers, Ashley F., and Timms, Nicholas E.
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Astrophysics - Earth and Planetary Astrophysics ,Physics - Geophysics - Abstract
Over the Nullarbor Plain in South Australia, the Desert Fireball Network detected a fireball on the night of 1 June 2019 (7:30 pm local time), and six weeks later recovered a single meteorite (42 g) named Arpu Kuilpu. This meteorite was then distributed to a consortium of collaborating institutions to be measured and analyzed by a number of methodologies including: SEM-EDS, EPMA, ICP-MS, gamma-ray spectrometry, ideal gas pycnometry, magnetic susceptibility measurement, {\mu}CT, optical microscopy, and accelerator and noble gas mass spectrometry techniques. These analyses revealed that Arpu Kuilpu is an unbrecciated H5 ordinary chondrite, with minimal weathering (W0-1) and minimal shock (S2). The olivine and pyroxene mineral compositions (in mol%) are Fa: 19.2 +- 0.2, and Fs: 16.8 +- 0.2, further supporting the H5 type and class. The measured oxygen isotopes are also consistent with an H chondrite ({\delta}17O = 2.904 +- 0.177; {\delta}18O = 4.163 +- 0.336; {\Delta}17O = 0.740 +- 0.002). Ideal gas pycnometry measured bulk and grain densities of 3.66 +- 0.02 and 3.77 +- 0.02 g cm-3, respectively, yielding a porosity of 3.0 % +- 0.7. The magnetic susceptibility of this meteorite is log X = 5.16 +- 0.08. The most recent impact-related heating event experienced by Arpu Kuilpu was measured by 40Ar/39Ar chronology to be 4467 +- 16 Ma, while the cosmic ray exposure age is estimated to be between 6-8 Ma. The noble gas isotopes, radionuclides, and fireball observations all indicate that Arpu Kuilpu's meteoroid was quite small (maximum radius of 10 cm, though more likely between 1-5 cm). Although this meteorite is a rather ordinary ordinary chondrite, its prior orbit resembled that of a Jupiter Family Comet (JFC) further lending support to the assertion that many cm- to m-sized objects on JFC orbits are asteroidal rather than cometary in origin.
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- 2024
3. Merger of massive galaxy cluster CL0238.3+2005 at z~0.4: just after pericenter passage?
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Lyskova, N., Churazov, E., Khabibullin, I., Bikmaev, I. F., Burenin, R. A., Forman, W. R., Khamitov, I. M., Rajpurohit, K., Sunyaev, R., Jones, C., Kraft, R., Zaznobin, I., Gorbachev, M. A., Suslikov, M. V., Gumerov, R. I., and Sakhibullin, N. A.
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Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
Massive clusters of galaxies are very rare in the observable Universe. Even rarer are mergers of such clusters observed close to pericenter passage. Here, we report on one such case: a massive (~ $10^{15}\,M_\odot$) and hot (kT ~ 10 keV) cluster CL0238.3+2005 at $z\approx 0.42$. For this cluster, we combine X-ray data from SRG/eROSITA and Chandra, optical images from DESI, and spectroscopy from BTA and RTT-150 telescopes. The X-ray and optical morphologies suggest an ongoing merger with the projected separation of subhalos of $\sim 200$ kpc. The line-of-sight velocity of galaxies tentatively associated with the two merging halos differs by 2000-3000 km/s. We conclude that, most plausibly, the merger axis is neither close to the line of sight nor to the sky plane. We compare CL0238 with two well-known clusters MACS0416 and Bullet, and conclude that CL0238 corresponds to an intermediate phase between the pre-merging MACS0416 cluster and the post-merger Bullet cluster. Namely, this cluster has recently (only $\lesssim 0.1$ Gyr ago) experienced an almost head-on merger. We argue that this "just after" system is a very rare case and an excellent target for lensing, Sunyaev-Zeldovich effect, and X-ray studies that can constrain properties ranging from dynamics of mergers to self-interacting dark matter, and plasma effects in intracluster medium that are associated with shock waves, e.g., electron-ion equilibration efficiency and relativistic particle acceleration., Comment: submitted to A&A; comments are welcome
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- 2024
4. Probing the high frequency variability of NGC 5044: the key to AGN feedback
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Schellenberger, Gerrit, O'Sullivan, Ewan, David, Laurence, Vrtilek, Jan, Romero, Charles, Petitpas, Glen, Forman, William, Giacintucci, Simona, Gurwell, Mark, Jones, Christine, Rajpurohit, Kamlesh, Ubertosi, Francesco, and Venturi, Tiziana
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
The active galactic nucleus (AGN) feeding and feedback process in the centers of galaxy clusters and groups is still not well understood. NGC 5044 is the ideal system in which to study AGN feedback. It hosts the largest known reservoir of cold gas in any cool-core galaxy group, and features several past epochs of AGN feedback imprinted as cavities in the X-ray bright intragroup medium (IGrM), as well as parsec scale jets. We present Submillimeter Array (SMA), Karl G. Jansky Very Large Array (VLA), James Clerk Maxwell Telescope (JCMT), and Atacama Large Millimeter/submillimeter Array (ALMA) high frequency observations of NGC 5044 to assess the time variability of the mmwaveband emission from the accretion disk, and quantify the Spectral Energy Distribution (SED) from the radio to sub-millimeter band. The SED is well described by advection dominated accretion flow (ADAF) model and self-absorbed jet emission from an aging plasma with tau = 1kyr. We find a characteristic variability timescale of 150 days, which constrains the ADAF emission region to about 0.1pc, and the magnetic field to 4.7mG in the jets and and 870G in the accretion disk. A longer monitoring/sampling will allow to understand if the underlying process is truly periodic in nature., Comment: 17 pages, 7 figures, accepted for publication in ApJ
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- 2024
5. Computational Methods to Investigate Intrinsically Disordered Proteins and their Complexes
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Liu, Zi Hao, Tsanai, Maria, Zhang, Oufan, Forman-Kay, Julie, and Head-Gordon, Teresa
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Physics - Biological Physics ,Quantitative Biology - Biomolecules - Abstract
In 1999 Wright and Dyson highlighted the fact that large sections of the proteome of all organisms are comprised of protein sequences that lack globular folded structures under physiological conditions. Since then the biophysics community has made significant strides in unraveling the intricate structural and dynamic characteristics of intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs). Unlike crystallographic beamlines and their role in streamlining acquisition of structures for folded proteins, an integrated experimental and computational approach aimed at IDPs/IDRs has emerged. In this Perspective we aim to provide a robust overview of current computational tools for IDPs and IDRs, and most recently their complexes and phase separated states, including statistical models, physics-based approaches, and machine learning methods that permit structural ensemble generation and validation against many solution experimental data types.
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- 2024
6. A combination of protein phosphatase 2A inhibition and checkpoint immunotherapy: a perfect storm.
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Clark, Mary, Lu, Rongze, Ho, Winson, Dias, Matheus, Bernards, René, and Forman, Stephen
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PP2A ,TIL therapy ,checkpoint inhibitor ,Humans ,Protein Phosphatase 2 ,Immunotherapy ,Immune Checkpoint Inhibitors ,Neoplasms ,Animals - Abstract
Immune checkpoint blockade has emerged as a potent new tool in the war on cancer. However, only a subset of cancer patients benefit from this therapeutic modality, sparking a search for combination therapies to increase the fraction of responding patients. We argue here that inhibition of protein phosphatase 2A (PP2A) is a promising approach to increase responses to immune checkpoint blockade and other therapies that rely on the presence of tumor-reactive T cells. Inhibition of PP2A increases neoantigen expression on tumor cells, activates the cGAS/STING pathway, suppresses regulatory T cells, and increases cytotoxic T cell activation. In preclinical models, inhibition of PP2A synergizes with immune checkpoint blockade and emerging evidence indicates that patients who have tumors with mutations in PP2A respond better to immune checkpoint blockade. Therefore, inhibition of PP2A activity may be an effective way to sensitize cancer cells to immune checkpoint blockade and cell-based therapies using tumor-reactive T cells.
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- 2024
7. A Deep Dive into the NGC 741 Galaxy Group: Insights into a Spectacular Head-Tail Radio Galaxy from VLA, MeerKAT, uGMRT and LOFAR
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Rajpurohit, K., O'Sullivan, E., Schellenberger, G., Brienza, M., Vrtilek, J. M., Forman, W., David, L. P., Clarke, T., Botteon, A., Vazza, F., Giacintucci, S., Jones, C., Brüggen, M., Shimwell, T. W., Drabent, A., Loi, F., Loubser, S. I., Kolokythas, K., Babyk, I., and Röttgering, H. J. A.
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We present deep, wideband multifrequency radio observations (144 MHz$-$8 GHz) of the remarkable galaxy group NGC 741, which yield crucial insights into the interaction between the infalling head-tail radio galaxy (NGC 742) and the main group. Our new data provide an unprecedentedly detailed view of the NGC 741-742 system, including the shock cone, disrupted jets from NGC 742, the long ($\sim$ 255 kpc) braided southern radio tail, and eastern lobe-like structure, and reveal, for the first time, complex radio filaments throughout the tail and lobe, and a likely vortex ring behind the shock cone. The cone traces the bow shock caused by the supersonic ($\mathcal{M}\sim2$) interaction between the head-tail radio galaxy NGC 742 and the intragroup medium (IGrM) while the ring may have been formed by interaction between the NGC 742 shock and a previously existing lobe associated with NGC 741. This interaction plausibly compressed and re-accelerated the radio plasma. We estimate that shock-heating by NGC 742 has likely injected $\sim$2-5$\times$10$^{57}$ erg of thermal energy into the central 10 kpc cooling region of the IGrM, potentially affecting the cooling and feedback cycle of NGC 741. A comparison with Chandra X-ray images shows that some of the previously detected thermal filaments align with radio edges, suggesting compression of the IGrM as the relativistic plasma of the NGC 742 tail interacts with the surrounding medium. Our results highlight that multi-frequency observations are key to disentangling the complex, intertwined origins of the variety of radio features seen in the galaxy group NGC 741, and the need for simulations to reproduce all the detected features., Comment: 26 pages, 15 figures, submitted to ApJ
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- 2024
8. Unveiling the Cosmic Chemistry: Revisiting the Mass-Metallicity Relation with JWST/NIRSpec at 4 < z < 10
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Sarkar, Arnab, Chakraborty, Priyanka, Vogelsberger, Mark, McDonald, Michael, Torrey, Paul, Garcia, Alex M., Khullar, Gourav, Ferland, Gary J., Forman, William, Wolk, Scott, Schneider, Benjamin, Bautz, Mark, Miller, Eric, Grant, Catherine, and ZuHone, John
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Astrophysics - Astrophysics of Galaxies - Abstract
We present star formation rates (SFR), the mass-metallicity relation (MZR), and the SFR-dependent MZR across redshifts 4 to 10 using 81 star-forming galaxies observed by the JWST NIRSpec employing both low-resolution PRISM and medium-resolution gratings, including galaxies from the JADES GOODS-N and GOODS-S fields, the JWST-PRIMAL Legacy Survey, and additional galaxies from the literature in Abell 2744, SMACS-0723, RXJ2129, BDF, COSMOS, and MACS1149 fields. These galaxies span a 3 dex stellar mass range of $10^7 < M_{\ast}/M_{\odot} < 10^{10}$, with an average SFR of $7.2 \pm 1.2 M_{\odot} {\rm yr}^{-1}$ and an average metallicity of $12+{\rm log(O/H)} = 7.91 \pm 0.08$. Our findings align with previous observations up to $z=8$ for the MZR and indicate no deviation from local universe FMR up to this redshift. Beyond $z=8$, we observe a significant deviation $\sim 0.27$ dex) in FMR, consistent with recent JWST findings. We also integrate CEERS (135 galaxies) and JADES (47 galaxies) samples with our data to study metallicity evolution with redshift in a combined sample of 263 galaxies, revealing a decreasing metallicity trend with a slope of $0.067 \pm 0.013$, consistent with IllustrisTNG and EAGLE, but contradicts with FIRE simulations. We introduce an empirical mass-metallicity-redshift (MZ-$z$ relation): $12+{\rm log(O/H)}=6.29 + 0.237 \times{\rm log}(M_{\ast}/M_{\odot}) - 0.06 \times (1+z)$, which accurately reproduces the observed trends in metallicity with both redshift and stellar mass. This trend underscores the ``Grand Challenge'' in understanding the factors driving high-redshift galactic metallicity trends, such as inflow, outflow, and AGN/stellar feedback -- and emphasizes the need for further investigations with larger samples and enhanced simulations., Comment: 24 Pages, 9 Figures. Submitted to ApJ. Comments are welcome!
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- 2024
9. A Swift X-ray view of the SMS4 sample -- II: X-ray properties of 17 bright radio sources
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Maselli, Alessandro, Forman, William R., Jones, Christine, Kraft, Ralph P., and Perri, Matteo
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
Based on a proposal to observe 18 bright radio sources from the SMS4 catalog with the Neil Gehrels Swift Observatory (hereafter Swift), we obtained X-ray observations of 17 targets (one target was not observed). Following up our first paper that discussed 31 sources (see Maselli et al. 2022; 20 sources detected as point sources and one very extended source), we present results for this final sample of 17 radio sources, that previously lacked dedicated, pointed narrow FOV X-ray observations. One of these 17 sources, undetected by Swift due to a very short exposure, was instead detected by eROSITA, and given in the Data Release 1 (DR1) Catalog. No 1eRASS source was found in the DR1 for the remaining source, unobserved by Swift. The new Swift observations led to eleven X-ray source detections in the 0.3-10 keV band and six upper limits. We investigated the extent of the X-ray emission, the hardness ratio, and when statistics allowed we carried out a spectral analysis. The X-ray emission of eight sources is consistent with point-like emission, while three sources show clear evidence of extent, each with peculiar properties. We used the X-ray determined positions and uncertainties of the twelve detected sources to establish associations with infrared and optical sources from the AllWISE and the GSC 2.4.2 catalogs. Requiring a detection in both the infrared and the optical bands to establish a candidate counterpart for our X-ray detections, we identify counterparts for all twelve sources. We discuss the interesting structure of MRC B0344-345 and PKS B2148-555, two of the six extended X-ray sources that we detected in both our Swift campaigns, and suggest they are very promising for further X-ray and radio investigations. For the 38 SMS4 sources that lack pointed, narrow FOV X-ray telescope observations, after our Swift campaigns, we list 18 likely counterparts from the eROSITA DR1 catalog., Comment: 25 pages, 7 figures, 11 tables; accepted for publication in the Astrophysical Journal Supplement Series. arXiv admin note: text overlap with arXiv:2208.04763
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- 2024
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10. Influences of stoichiometry on steadily propagating triple flames in counterflows
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Rajamanickam, Prabakaran, Coenen, Wilfried, Sánchez, Antonio L., and Williams, Forman A.
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Physics - Fluid Dynamics - Abstract
Most studies of triple flames in counterflowing streams of fuel and oxidizer have been focused on the symmetric problem in which the stoichiometric mixture fraction is $1/2$. There then exist lean and rich premixed flames of roughly equal strengths, with a diffusion flame trailing behind from the stoichiometric point at which they meet. In the majority of realistic situations, however, the stoichiometric mixture fraction departs appreciably from unity, typically being quite small. With the objective of clarifying the influences of stoichiometry, attention is focused on one of the simplest possible models, addressed here mainly by numerical integration. When the stoichiometric mixture fraction departs appreciably from $1/2$, one of the premixed wings is found to be dominant to such an extent that the diffusion flame and the other premixed flame are very weak by comparison. These curved, partially premixed flames are expected to be relevant in realistic configurations. In addition, a simple kinematic balance is shown to predict the shape of the front and the propagation velocity reasonably well in the limit of low stretch and low curvature.
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- 2024
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11. Near-limit H$_2$-O$_2$-N$_2$ combustion in nonpremixed counterflow mixing layers
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Carpio, Jaime, Rajamanickam, Prabakaran, Sánchez, Antonio L., and Williams, Forman A.
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Physics - Fluid Dynamics - Abstract
Numerical computations employing detailed chemistry are used to characterize the different combustion modes emerging in mixing layers separating nitrogen-diluted counterflowing planar streams of hydrogen and oxygen. Attention is focused on high degrees of dilution, resulting in near-limit flames, with peak temperatures close to the crossover temperature. A bifurcation diagram is presented in a plane, having the stoichiometric mixture fraction and normalized strain rate as coordinates, that identifies six different combustion regimes involving four different flame types, namely, diffusion-flame sheets, advancing and retreating edge flames, multiple flame tubes, and single isolated flame tubes. Multiple-tube flame configurations vary from small, round, widely separated flame strings at high strain rates to wide, flat, densely packed flame strips, with narrow flame-free gaps between them, at lower strain rates, and they are steady and stable in various arrays over a continuum of tube-separation distances. The observed flame behavior exhibits hysteresis in a certain range of parameters, with the structure that is established depending on the ignition mechanism, as it also does at high strain rates, and a continuum of different stable steady-state flame configurations exists, each accessed from a different initial condition.
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- 2024
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12. Experimental and Computational Investigation of the Influence of Ethanol on Auto-ignition of n-Heptane in Non-Premixed Flows
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Ji, Liang, Seshadri, Kalyanasundaram, and Williams, Forman A.
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Physics - Chemical Physics - Abstract
Experimental and computational investigations are carried out to elucidate the influence of ethanol addition on n-heptane auto-ignition in counterflows. An axisymmetric stream of air, temperature gradually increased, is directed onto the surface of an evaporating pool of a liquid fuel. The air-stream temperature at auto-ignition is measured at various strain rates for n-heptane, ethanol, and various n-heptane/ethanol mixtures. Critical conditions for auto-ignition are predicted employing San Diego Mechanism for both fuels and fuel mixtures, and the results are compared with measurements. Measurements and predictions show that low-temperature chemistry (LTC) plays a significant role in promoting auto-ignition of n-heptane at low strain rates, but there is insufficient residence time at high strain rates for LTC to take place, so auto-ignition is promoted by high-temperature chemistry. Experimental and computational results show addition of ethanol inhibits LTC of n-heptane. To identify the responsible elementary steps, computations are performed to identify those dominate O2 consumption and contribute to the temperature rise in the reaction zone for n-heptane and n-heptane/ethanol mixtures at low strain rates. For n-heptane, O2 is consumed primarily by the low-temperature steps that result in ketohydroperoxide; the temperature rise is produced by subsequent LTC steps. For the mixtures, a key step consuming O2 is O2 + CH3CHOH = HO2 + CH3CHO, and the heat release occurs through the classical high-temperature reaction mechanism. Thus, the inhibition of auto-ignition that is observed to occur when ethanol is added to n-heptane arises from the competition for O2 between this step and the LTC addition of O2 to the heptyl radical and to the radical arising from the subsequent isomerization, for n-heptane.
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- 2024
13. A curated rotamer library for common post-translational modifications of proteins.
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Zhang, Oufan, Naik, Shubhankar, Liu, Zi, Forman-Kay, Julie, and Head-Gordon, Teresa
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Protein Processing ,Post-Translational ,Proteins ,Databases ,Protein ,Intrinsically Disordered Proteins ,Algorithms ,Protein Folding ,Monte Carlo Method ,Protein Conformation ,Amino Acids ,Software - Abstract
MOTIVATION: Sidechain rotamer libraries of the common amino acids of a protein are useful for folded protein structure determination and for generating ensembles of intrinsically disordered proteins (IDPs). However, much of protein function is modulated beyond the translated sequence through the introduction of post-translational modifications (PTMs). RESULTS: In this work, we have provided a curated set of side chain rotamers for the most common PTMs derived from the RCSB PDB database, including phosphorylated, methylated, and acetylated sidechains. Our rotamer libraries improve upon existing methods such as SIDEpro, Rosetta, and AlphaFold3 in predicting the experimental structures for PTMs in folded proteins. In addition, we showcase our PTM libraries in full use by generating ensembles with the Monte Carlo Side Chain Entropy (MCSCE) for folded proteins, and combining MCSCE with the Local Disordered Region Sampling algorithms within IDPConformerGenerator for proteins with intrinsically disordered regions. AVAILABILITY AND IMPLEMENTATION: The codes for dihedral angle computations and library creation are available at https://github.com/THGLab/ptm_sc.git.
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- 2024
14. Multi-Messenger Emission Characteristics of Blazars
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Gamble Jr, Ronald, Forman, Jordan, Barnes, Amethyst, Srinivasaragavan, Gokul, Holt, Isiah, and Jones Jr, Marvin
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Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Astrophysics of Galaxies - Abstract
Multi-Messenger observations and theory of astrophysical objects is fast becoming a critical research area in the astrophysics scientific community. In particular, point-like objects like that of BL Lac, flat spectrum radio quasars (FSRQ), and blazar candidates of uncertain type (BCU) are of distinct interest among those who look at the synchrotron, Compton, neutrino, and cosmic ray emissions sourced from compact objects. Notably, there is also much interest in the correlation between multi-frequency observations of blazars and neutrino surveys on source demographics. In this review we look at such multi-frequency and multi-physics correlations of the radio, X-ray, and $\gamma$-ray fluxes of different classes of blazars from a collection of survey catalogues. This multi-physics survey of blazars shows that there are characteristic cross-correlations in the spectra of blazars when considering their multi-frequency and multi-messenger emission. Accompanying this will be a review of cosmic ray and neutrino emissions from blazars and their characteristics., Comment: 13 pages, 4 figures (reviewed, Frontiers: Astronomy & Space Sciences, The Dynamic Universe: Realizing the Potential of Time Domain and Multimessenger Astrophysics)
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- 2024
15. A candidate supermassive black hole in a gravitationally-lensed galaxy at $z\approx10$
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Kovacs, Orsolya E., Bogdan, Akos, Natarajan, Priyamvada, Werner, Norbert, Azadi, Mojegan, Volonteri, Marta, Tremblay, Grant R., Chadayammuri, Urmila, Forman, William R., Jones, Christine, and Kraft, Ralph P.
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
While supermassive black holes (BHs) are widely observed in the nearby and distant universe, their origin remains debated with two viable formation scenarios with light and heavy seeds. In the light seeding model, the first BHs form from the collapse of massive stars with masses of $10-100 \ \rm{M_{\odot}}$, while the heavy seeding model posits the formation of $10^{4-5} \ \rm{M_{\odot}}$ seeds from direct collapse. The detection of BHs at redshifts $z\gtrsim10$, edging closer to their formation epoch, provides critical observational discrimination between these scenarios. Here, we focus on the JWST-detected galaxy, GHZ 9, at $z\approx10$ that is lensed by the foreground cluster, Abell 2744. Based on 2.1 Ms deep Chandra observations, we detect a candidate X-ray AGN, which is spatially coincident with the high-redshift galaxy, GHZ 9. The BH candidate is inferred to have a bolometric luminosity of $(1.0^{+0.5}_{-0.4})\times10^{46} \ \rm{erg \ s^{-1}}$, which corresponds to a BH mass of $(8.0^{+3.7}_{-3.2})\times10^7 \ \rm{M_{\odot}}$ assuming Eddington-limited accretion. This extreme mass at such an early cosmic epoch suggests the heavy seed origin for this BH candidate. Based on the Chandra and JWST discoveries of extremely high-redshift quasars, we have constructed the first simple AGN luminosity function extending to $z\approx10$. Comparison of this luminosity function with theoretical models indicates an over-abundant $z\approx10$ BH population, consistent with a higher-than-expected seed formation efficiency., Comment: 9 pages, 4 figures, accepted for publication in The Astrophysical Journal Letters
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- 2024
16. Sexual behavior and personal initiative to take the HIV test among men who have sex with men in Semarang, Indonesia
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Sidjabat, Forman N., Prihartono, Nurhayati A., Syarif, Syahrizal, and Damayanti, Rita
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- 2024
17. Visiting Father's Girlfriends
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Forman, Gideon
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Arts, visual and performing ,Literature/writing - Abstract
IN the early 1970s my parents were in the process of separating, and by 1975, the year of my bar mitzvah at Toronto's Holy Blossom Temple, their union was toast. [...]
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- 2024
18. PARP1 condensates differentially partition DNA repair proteins and enhance DNA ligation
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Chin Sang, Christopher, Moore, Gaelen, Tereshchenko, Maria, Zhang, Hongshan, Nosella, Michael L, Dasovich, Morgan, Alderson, T Reid, Leung, Anthony K L, Finkelstein, Ilya J, Forman-Kay, Julie D, and Lee, Hyun O
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- 2024
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19. Comparing transplant outcomes in ALL patients after myeloablative conditioning in mismatch-related or unrelated donor settings
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Otoukesh, Salman, Yang, Dongyun, Mokhtari, Sally, Pourhassan, Hoda, Agrawal, Vaibhav, Arslan, Shukaib, Amanam, Idoroenyi, Ball, Brian, Koller, Paul, Salhotra, Amandeep, Sandhu, Karamjeet, Aribi, Ahmed, Artz, Andrew, Aldoss, Ibrahim, Pullarkat, Vinod, Ali, Haris, Blackmon, Amanda, Becker, Pamela, Curtin, Peter, Stewart, Forrest, Smith, Eileen, Stein, Anthony, Marcucci, Guido, Forman, Stephen J., Nakamura, Ryotaro, and Al Malki, Monzr M.
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- 2024
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20. Digital innovation for cancer risk assessment allows large-scale service redevelopment of regional cancer genetics service delivery
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Youngs, Alice, Forman, Andrea, Elms, Marisa, Kohut, Kelly, Hlaing, Min Theik, Short, John, Hanson, Helen, and Snape, Katie
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- 2024
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21. Sex differences in the association between skeletal muscle energetics and perceived physical fatigability: the Study of Muscle, Mobility and Aging (SOMMA)
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Gay, Emma L., Coen, Paul M., Harrison, Stephanie, Garcia, Reagan E., Qiao, Yujia (Susanna), Goodpaster, Bret H., Forman, Daniel E., Toledo, Frederico G. S., Distefano, Giovanna, Kramer, Philip A., Ramos, Sofhia V., Molina, Anthony J. A., Nicklas, Barbara J., Cummings, Steven R., Cawthon, Peggy M., Hepple, Russell T., Newman, Anne B., and Glynn, Nancy W.
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- 2024
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22. Abbreviated MRI in the evaluation of dizziness: report turnaround times and impact on length of stay compared to CT, CTA, and conventional MRI
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Tu, Long H., Tegtmeyer, Kyle, de Oliveira Santo, Irene Dixe, Venkatesh, Arjun K., Forman, Howard P., Mahajan, Amit, and Melnick, Edward R.
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- 2024
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23. CHEX-MATE: Robust reconstruction of temperature profiles in galaxy clusters with XMM-Newton
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Rossetti, M., Eckert, D., Gastaldello, F., Rasia, E., Pratt, G. W., Ettori, S., Molendi, S., Arnaud, M., Balboni, M., Bartalucci, I., Batalha, R. M., Borgani, S., Bourdin, H., De Grandi, S., De Luca, F., De Petris, M., Forman, W., Gaspari, M., Ghizzardi, S., Iqbal, A., Kay, S., Lovisari, L., Maughan, B. J., Mazzotta, P., Pointecouteau, E., Riva, G., Sayers, J., and Sereno, M.
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Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
The "Cluster HEritage project with \xmm: Mass Assembly and Thermodynamics at the Endpoint of structure formation" (CHEX-MATE) is a multi-year Heritage program, to obtain homogeneous XMM-Newton observations of a representative sample of 118 galaxy clusters. The observations are tuned to reconstruct the distribution of the main thermodynamic quantities of the ICM up to $R_{500}$ and to obtain individual mass measurements, via the hydrostatic-equilibrium equation, with a precision of 15-20%. Temperature profiles are a necessary ingredient for the scientific goals of the project and it is thus crucial to derive the best possible temperature measurements from our data. This is why we have built a new pipeline for spectral extraction and analysis of XMM-Newton data, based on a new physically motivated background model and on a Bayesian approach with Markov Chain Monte Carlo (MCMC) methods, that we present in this paper for the first time. We applied this new method to a subset of 30 galaxy clusters representative of the CHEX-MATE sample and show that we can obtain reliable temperature measurements up to regions where the source intensity is as low as 20% of the background, keeping systematic errors below 10%. We compare the median profile of our sample and the best fit slope at large radii with literature results and we find a good agreement with other measurements based on XMM-Newton data. Conversely, when we exclude from our analysis the most contaminated regions, where the source intensity is below 20 of the background, we find significantly flatter profiles, in agreement with predictions from numerical simulations and independent measurements with a combination of Sunyaev-Zeldovich and X-ray imaging data., Comment: Accepted for publication in Astronomy & Astrophysics. Table C.1. available in electronic format at http://xmm-heritage.oas.inaf.it/data/Rossetti24_table_cds.dat
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- 2024
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24. Understanding the Nature of the Ultra-Steep Spectrum Diffuse Radio Source in the Galaxy Cluster Abell 272
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Whyley, Arthur, Randall, Scott W., Clarke, Tracy E., van Weeren, Reinout J., Rajpurohit, Kamlesh, Forman, William R., Edge, Alastair C., Blanton, Elizabeth L., Lovisari, Lorenzo, and Intema, Huib T.
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Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Astrophysics of Galaxies ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
Ultra-steep spectrum (USS) radio sources with complex filamentary morphologies are a poorly understood subclass of diffuse radio source found in galaxy clusters. They are characterised by power law spectra with spectral indices less than -1.5, and are typically located in merging clusters. We present X-ray and radio observations of the galaxy cluster A272, containing a USS diffuse radio source. The system is an ongoing major cluster merger with an extended region of bright X-ray emission south of the core. Surface brightness analysis yields a $3\sigma$ detection of a merger shock front in this region. We obtain shock Mach numbers $M_\rho = 1.20 \pm 0.09$ and $M_T = 1.7 \pm 0.3$ from the density and temperature jumps, respectively. Optical data reveals that the system is a merger between a northern cool core cluster and a southern non-cool core cluster. We find that the USS source, with spectral index $\alpha^{\text{74 MHz}}_{\text{1.4 GHz}} = -1.9 \pm 0.1$, is located in the bright southern region. Radio observations show that the source has a double-lobed structure with complex filaments, and is centred on the brightest cluster galaxy of the southern subcluster. We provide two suggestions for the origin of this source; the first posits the source as an AGN relic that has been re-energised by the passing of a merger shock front, while the second interprets the complex structure as the result of two overlapping AGN radio outbursts. We also present constraints on the inverse Compton emission at the location of the source., Comment: 14 pages, 16 figures, submitted to MNRAS
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- 2024
25. Cosmological constraints from the Chandra-Planck galaxy cluster sample
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Aymerich, G., Douspis, M., Pratt, G. W., Salvati, L., Soubrié, E., Andrade-Santos, F., Forman, W., Jones, C., Aghanim, N., Kraft, R., and van Weeren, R. J.
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We provide a new scaling relation between $Y_{\text{SZ}}$, the integrated Sunyaev-Zeldovich signal and $M_{500}^{Y_{\text{X}}}$, the cluster mass derived from X-ray observations, using a sample of clusters from the Planck Early Sunyaev-Zeldovich (ESZ) catalogue observed in X-rays by Chandra, and compare it to the results of the Planck collaboration obtained from XMM-Newton observations of a subsample of the ESZ. We calibrated a mass bias on a subset of the Planck cosmological cluster sample using published weak-lensing data from CCCP and MENeaCS, for the new scaling relation as well as that from the Planck collaboration. We propose a novel method to account for selection effects and find a mass bias of $(1-b)=0.89\pm0.04$ for the Chandra-calibrated scaling relation, and $(1-b)=0.76\pm0.04$ for the XMM-Newton-calibrated scaling relation. We apply the scaling relations we derived to the full Planck cosmological cluster sample and obtain identical cosmological constraints regardless of the X-ray sample used, with $\sigma_8 =0.77\pm0.02$, $\Omega_m=0.31\pm0.02$, and $S_8= \sigma_8 \sqrt{\Omega_m / 0.3}=0.78\pm0.02$. We also provide constraints with a redshift evolution of the scaling relation fitted from the data instead of fixing it to the self-similar value. We find a redshift evolution significantly deviating from the self-similar value, leading to a higher value of $S_8=0.81\pm0.02$. We compare our results to those from various cosmological probes, and find that our $S_8$ constraints are competitive with the tightest constraints from the literature. When assuming a self-similar redshift evolution, our constraints are in agreement with most late-time probes and in tension with constraints from the CMB primary anisotropies. When relaxing the assumption of redshift evolution and fitting it to the data, we find no significant tension with results from either late-time probes or the CMB., Comment: 21 pages, 20 figures, accepted by A&A
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- 2024
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26. Merger-driven multi-scale ICM density perturbations: testing cosmological simulations and constraining plasma physics
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Heinrich, Annie, Zhuravleva, Irina, Zhang, Congyao, Churazov, Eugene, Forman, William, and van Weeren, Reinout J.
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Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
The hot intracluster medium (ICM) provides a unique laboratory to test multi-scale physics in numerical simulations and probe plasma physics. Utilizing archival Chandra observations, we measure density fluctuations in the ICM in a sample of 80 nearby (z<1) galaxy clusters and infer scale-dependent velocities within regions affected by mergers (r
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- 2024
27. Electrostatics of Salt-Dependent Reentrant Phase Behaviors Highlights Diverse Roles of ATP in Biomolecular Condensates
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Lin, Yi-Hsuan, Kim, Tae Hun, Das, Suman, Pal, Tanmoy, Wessén, Jonas, Rangadurai, Atul Kaushik, Kay, Lewis E., Forman-Kay, Julie D., and Chan, Hue Sun
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Quantitative Biology - Biomolecules - Abstract
Liquid-liquid phase separation (LLPS) involving intrinsically disordered protein regions (IDRs) is a major physical mechanism for biological membraneless compartmentalization. The multifaceted electrostatic effects in these biomolecular condensates are exemplified here by experimental and theoretical investigations of the different salt- and ATP-dependent LLPSs of an IDR of messenger RNA-regulating protein Caprin1 and its phosphorylated variant pY-Caprin1, exhibiting, e.g., reentrant behaviors in some instances but not others. Experimental data are rationalized by physical modeling using analytical theory, molecular dynamics, and polymer field-theoretic simulations, indicating that interchain ion bridges enhance LLPS of polyelectrolytes such as Caprin1 and the high valency of ATP-magnesium is a significant factor for its colocalization with the condensed phases, as similar trends are observed for other IDRs. The electrostatic nature of these features complements ATP's involvement in $\pi$-related interactions and as an amphiphilic hydrotrope, underscoring a general role of biomolecular condensates in modulating ion concentrations and its functional ramifications., Comment: 69 pages, 2 main-text tables, 9 main-text figures, 6 supporting figures, 167 references. Submitted, in revision at eLife
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- 2024
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28. On the Particle Acceleration Mechanisms in a Double Radio Relic Galaxy Cluster, Abell 1240
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Sarkar, Arnab, Andrade-Santos, Felipe, van Weeren, Reinout J., Kraft, Ralph P., Hoang, Duy N., Shimwell, Timothy W., Nulsen, Paul, Forman, William, Randall, Scott, Su, Yuanyuan, Chakraborty, Priyanka, Jones, Christine, Miller, Eric, Bautz, Mark, and Grant, Catherine E.
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Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Astrophysics of Galaxies - Abstract
We present a 368 ks deep Chandra observation of Abell~1240, a binary merging galaxy cluster at a redshift of 0.195 with two Brightest Cluster Galaxies (BCGs) may have passed each other 0.3 Gyr ago. Building upon previous investigations involving GMRT, VLA, and LOFAR data, our study focuses on two prominent extended radio relics at the north-west (NW) and south-east (SE) of the cluster core. By leveraging the high-resolution Chandra imaging, we have identified two distinct surface brightness edges at $\sim$ 1 Mpc and 1.2 Mpc NW and SE of the cluster center, respectively, coinciding with the outer edges of both relics. Our temperature measurements hint the edges to be shock front edges. The Mach numbers, derived from the gas density jumps, yield $\cal{M}_{\rm SE}$ = 1.49$^{+0.22}_{-0.24}$ for the South Eastern shock and $\cal{M}_{\rm NW}$ = 1.41$^{+0.17}_{-0.19}$ for the North Western shock. Our estimated Mach numbers are remarkably smaller compared to those derived from radio observations ($\cal{M}_{\rm SE}$ = 2.3 and $\cal{M}_{\rm NW}$ = 2.4), highlighting the prevalence of a re-acceleration scenario over direct acceleration of electrons from the thermal pool. Furthermore, we compare the observed temperature profiles across both shocks with that of predictions from collisional vs. collisionless models. Both shocks favor the Coulomb collisional model, but we could not rule out a purely collisionless model due to pre-shock temperature uncertainties., Comment: Accepted for publication in The Astrophysical Journal
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- 2024
29. An essential and highly selective protein import pathway encoded by nucleus-forming phage
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Morgan, Chase J, Enustun, Eray, Armbruster, Emily G, Birkholz, Erica A, Prichard, Amy, Forman, Taylor, Aindow, Ann, Wannasrichan, Wichanan, Peters, Sela, Inlow, Koe, Shepherd, Isabelle L, Razavilar, Alma, Chaikeeratisak, Vorrapon, Adler, Benjamin A, Cress, Brady F, Doudna, Jennifer A, Pogliano, Kit, Villa, Elizabeth, Corbett, Kevin D, and Pogliano, Joe
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Biochemistry and Cell Biology ,Biological Sciences ,Genetics ,1.1 Normal biological development and functioning ,Generic health relevance ,Viral Proteins ,Bacteriophages ,Protein Transport ,Cell Nucleus ,Virus Replication ,phage ,protein trafficking ,phage nucleus - Abstract
Targeting proteins to specific subcellular destinations is essential in prokaryotes, eukaryotes, and the viruses that infect them. Chimalliviridae phages encapsulate their genomes in a nucleus-like replication compartment composed of the protein chimallin (ChmA) that excludes ribosomes and decouples transcription from translation. These phages selectively partition proteins between the phage nucleus and the bacterial cytoplasm. Currently, the genes and signals that govern selective protein import into the phage nucleus are unknown. Here, we identify two components of this protein import pathway: a species-specific surface-exposed region of a phage intranuclear protein required for nuclear entry and a conserved protein, PicA (Protein importer of chimalliviruses A), that facilitates cargo protein trafficking across the phage nuclear shell. We also identify a defective cargo protein that is targeted to PicA on the nuclear periphery but fails to enter the nucleus, providing insight into the mechanism of nuclear protein trafficking. Using CRISPRi-ART protein expression knockdown of PicA, we show that PicA is essential early in the chimallivirus replication cycle. Together, our results allow us to propose a multistep model for the Protein Import Chimallivirus pathway, where proteins are targeted to PicA by amino acids on their surface and then licensed by PicA for nuclear entry. The divergence in the selectivity of this pathway between closely related chimalliviruses implicates its role as a key player in the evolutionary arms race between competing phages and their hosts.
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- 2024
30. Abell 746: A Highly Disturbed Cluster Undergoing Multiple Mergers
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Rajpurohit, K, Lovisari, L, Botteon, A, Jones, C, Forman, W, O’Sullivan, E, van Weeren, RJ, HyeongHan, K, Bonafede, A, Jee, MJ, Vazza, F, Brunetti, G, Cho, H, Domínguez-Fernández, P, Stroe, A, Finner, K, Brüggen, M, Vrtilek, JM, David, LP, Schellenberger, G, Wittman, D, Lusetti, G, Kraft, R, and De Gasperin, F
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Astronomical Sciences ,Physical Sciences ,Astronomical and Space Sciences ,Atomic ,Molecular ,Nuclear ,Particle and Plasma Physics ,Physical Chemistry (incl. Structural) ,Astronomy & Astrophysics ,Astronomical sciences ,Particle and high energy physics ,Space sciences - Abstract
We present deep XMM-Newton, Karl G. Jansky Very Large Array, and upgraded Giant Metrewave Radio Telescope observations of Abell 746, a cluster that hosts a plethora of diffuse emission sources that provide evidence for the acceleration of relativistic particles. Our new XMM-Newton images reveal a complex morphology of the thermal gas with several substructures. We observe an asymmetric temperature distribution across the cluster: the southern regions exhibit higher temperatures, reaching ∼9 keV, while the northern regions have lower temperatures (≤4 keV), likely due to a complex merger. We find evidence of three surface brightness edges and one candidate edge, of which three are merger-driven shock fronts. Combining our new data with published LOw-Frequency ARray observations has unveiled the nature of diffuse sources in this system. The bright NW relic shows thin filaments and a high degree of polarization with aligned magnetic field vectors. We detect a density jump, aligned with the fainter relic to the north. To the south, we detect high-temperature regions, consistent with the shock-heated regions and a density jump coincident with the northern tip of the southern radio structure. Its integrated spectrum shows a high-frequency steepening. Lastly, we find that the cluster hosts large-scale radio halo emission. A comparison of the thermal and nonthermal emission reveals an anticorrelation between the bright radio and X-ray features at the center. Our findings suggest that Abell 746 is a complex system that involves multiple mergers.
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- 2024
31. Locoregional delivery of IL-13Rα2-targeting CAR-T cells in recurrent high-grade glioma: a phase 1 trial
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Brown, Christine E, Hibbard, Jonathan C, Alizadeh, Darya, Blanchard, M Suzette, Natri, Heini M, Wang, Dongrui, Ostberg, Julie R, Aguilar, Brenda, Wagner, Jamie R, Paul, Jinny A, Starr, Renate, Wong, Robyn A, Chen, Wuyang, Shulkin, Noah, Aftabizadeh, Maryam, Filippov, Aleksandr, Chaudhry, Ammar, Ressler, Julie A, Kilpatrick, Julie, Myers-McNamara, Paige, Chen, Mike, Wang, Leo D, Rockne, Russell C, Georges, Joseph, Portnow, Jana, Barish, Michael E, D’Apuzzo, Massimo, Banovich, Nicholas E, Forman, Stephen J, and Badie, Behnam
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Biomedical and Clinical Sciences ,Clinical Sciences ,Oncology and Carcinogenesis ,Immunology ,Neurosciences ,Rare Diseases ,Brain Cancer ,Cancer ,Clinical Research ,Orphan Drug ,Clinical Trials and Supportive Activities ,Brain Disorders ,Vaccine Related ,6.2 Cellular and gene therapies ,6.1 Pharmaceuticals ,Evaluation of treatments and therapeutic interventions ,T-Lymphocytes ,Humans ,Glioma ,Glioblastoma ,Neoplasm Recurrence ,Local ,Immunotherapy ,Adoptive ,Receptors ,Chimeric Antigen ,Medical and Health Sciences ,Biomedical and clinical sciences ,Health sciences - Abstract
Chimeric antigen receptor T cell (CAR-T) therapy is an emerging strategy to improve treatment outcomes for recurrent high-grade glioma, a cancer that responds poorly to current therapies. Here we report a completed phase I trial evaluating IL-13Rα2-targeted CAR-T cells in 65 patients with recurrent high-grade glioma, the majority being recurrent glioblastoma (rGBM). Primary objectives were safety and feasibility, maximum tolerated dose/maximum feasible dose and a recommended phase 2 dose plan. Secondary objectives included overall survival, disease response, cytokine dynamics and tumor immune contexture biomarkers. This trial evolved to evaluate three routes of locoregional T cell administration (intratumoral (ICT), intraventricular (ICV) and dual ICT/ICV) and two manufacturing platforms, culminating in arm 5, which utilized dual ICT/ICV delivery and an optimized manufacturing process. Locoregional CAR-T cell administration was feasible and well tolerated, and as there were no dose-limiting toxicities across all arms, a maximum tolerated dose was not determined. Probable treatment-related grade 3+ toxicities were one grade 3 encephalopathy and one grade 3 ataxia. A clinical maximum feasible dose of 200 × 106 CAR-T cells per infusion cycle was achieved for arm 5; however, other arms either did not test or achieve this dose due to manufacturing feasibility. A recommended phase 2 dose will be refined in future studies based on data from this trial. Stable disease or better was achieved in 50% (29/58) of patients, with two partial responses, one complete response and a second complete response after additional CAR-T cycles off protocol. For rGBM, median overall survival for all patients was 7.7 months and for arm 5 was 10.2 months. Central nervous system increases in inflammatory cytokines, including IFNγ, CXCL9 and CXCL10, were associated with CAR-T cell administration and bioactivity. Pretreatment intratumoral CD3 T cell levels were positively associated with survival. These findings demonstrate that locoregional IL-13Rα2-targeted CAR-T therapy is safe with promising clinical activity in a subset of patients. ClinicalTrials.gov Identifier: NCT02208362 .
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- 2024
32. State-transition modeling of blood transcriptome predicts disease evolution and treatment response in chronic myeloid leukemia
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Frankhouser, David E, Rockne, Russell C, Uechi, Lisa, Zhao, Dandan, Branciamore, Sergio, O’Meally, Denis, Irizarry, Jihyun, Ghoda, Lucy, Ali, Haris, Trent, Jeffery M, Forman, Stephen, Fu, Yu-Hsuan, Kuo, Ya-Huei, Zhang, Bin, and Marcucci, Guido
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Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Genetics ,Rare Diseases ,Clinical Research ,Cancer ,Hematology ,Detection ,screening and diagnosis ,4.1 Discovery and preclinical testing of markers and technologies ,Mice ,Animals ,Transcriptome ,Fusion Proteins ,bcr-abl ,Protein Kinase Inhibitors ,Leukemia ,Myelogenous ,Chronic ,BCR-ABL Positive ,Tetracyclines ,Drug Resistance ,Neoplasm ,Clinical Sciences ,Immunology ,Cardiovascular medicine and haematology ,Clinical sciences ,Oncology and carcinogenesis - Abstract
Chronic myeloid leukemia (CML) is initiated and maintained by BCR::ABL which is clinically targeted using tyrosine kinase inhibitors (TKIs). TKIs can induce long-term remission but are also not curative. Thus, CML is an ideal system to test our hypothesis that transcriptome-based state-transition models accurately predict cancer evolution and treatment response. We collected time-sequential blood samples from tetracycline-off (Tet-Off) BCR::ABL-inducible transgenic mice and wild-type controls. From the transcriptome, we constructed a CML state-space and a three-well leukemogenic potential landscape. The potential's stable critical points defined observable disease states. Early states were characterized by anti-CML genes opposing leukemia; late states were characterized by pro-CML genes. Genes with expression patterns shaped similarly to the potential landscape were identified as drivers of disease transition. Re-introduction of tetracycline to silence the BCR::ABL gene returned diseased mice transcriptomes to a near healthy state, without reaching it, suggesting parts of the transition are irreversible. TKI only reverted the transcriptome to an intermediate disease state, without approaching a state of health; disease relapse occurred soon after treatment. Using only the earliest time-point as initial conditions, our state-transition models accurately predicted both disease progression and treatment response, supporting this as a potentially valuable approach to time clinical intervention, before phenotypic changes become detectable.
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- 2024
33. Lower muscle mitochondrial energetics is associated with greater phenotypic frailty in older women and men: the Study of Muscle, Mobility and Aging.
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Mau, Theresa, Barnes, Haley, Blackwell, Terri, Kramer, Philip, Bauer, Scott, Marcinek, David, Ramos, Sofhia, Forman, Daniel, Toledo, Frederico, Hepple, Russell, Kritchevsky, Stephen, Cummings, Steven, Newman, Anne, Coen, Paul, and Cawthon, Peggy
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Aging ,Mitochondria ,Muscle energetics ,Phenotypic frailty ,Male ,Aged ,Humans ,Female ,Frailty ,Frail Elderly ,Muscles ,Aging ,Mitochondria ,Adenosine Triphosphate - Abstract
BACKGROUND: Phenotypic frailty syndrome identifies older adults at greater risk for adverse health outcomes. Despite the critical role of mitochondria in maintaining cellular function, including energy production, the associations between muscle mitochondrial energetics and frailty have not been widely explored in a large, well-phenotyped, older population. METHODS: The Study of Muscle, Mobility and Aging (SOMMA) assessed muscle energetics in older adults (N = 879, mean age = 76.3 years, 59.2% women). 31Phosporous magnetic resonance spectroscopy measured maximal production of adenosine triphosphate (ATPmax) in vivo, while ex vivo high-resolution respirometry of permeabilized muscle fibers from the vastus lateralis measured maximal oxygen consumption supported by fatty acids and complex I- and II-linked carbohydrates (e.g., Max OXPHOSCI+CII). Five frailty criteria, shrinking, weakness, exhaustion, slowness, and low activity, were used to classify participants as robust (0, N = 397), intermediate (1-2, N = 410), or frail (≥ 3, N = 66). We estimated the proportional odds ratio (POR) for greater frailty, adjusted for multiple potential confounders. RESULTS: One-SD decrements of most respirometry measures (e.g., Max OXPHOSCI+CII, adjusted POR = 1.5, 95%CI [1.2,1.8], p = 0.0001) were significantly associated with greater frailty classification. The associations of ATPmax with frailty were weaker than those between Max OXPHOSCI+CII and frailty. Muscle energetics was most strongly associated with slowness and low physical activity components. CONCLUSIONS: Our data suggest that deficits in muscle mitochondrial energetics may be a biological driver of frailty in older adults. On the other hand, we did observe differential relationships between measures of muscle mitochondrial energetics and the individual components of frailty.
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- 2024
34. Comparing Large Language Model AI and Human-Generated Coaching Messages for Behavioral Weight Loss
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Huang, Zhuoran, Berry, Michael P., Chwyl, Christina, Hsieh, Gary, Wei, Jing, and Forman, Evan M.
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Computer Science - Computation and Language - Abstract
Automated coaching messages for weight control can save time and costs, but their repetitive, generic nature may limit their effectiveness compared to human coaching. Large language model (LLM) based artificial intelligence (AI) chatbots, like ChatGPT, could offer more personalized and novel messages to address repetition with their data-processing abilities. While LLM AI demonstrates promise to encourage healthier lifestyles, studies have yet to examine the feasibility and acceptability of LLM-based BWL coaching. 87 adults in a weight-loss trial rated ten coaching messages' helpfulness (five human-written, five ChatGPT-generated) using a 5-point Likert scale, providing additional open-ended feedback to justify their ratings. Participants also identified which messages they believed were AI-generated. The evaluation occurred in two phases: messages in Phase 1 were perceived as impersonal and negative, prompting revisions for Phase 2 messages. In Phase 1, AI-generated messages were rated less helpful than human-written ones, with 66 percent receiving a helpfulness rating of 3 or higher. However, in Phase 2, the AI messages matched the human-written ones regarding helpfulness, with 82% scoring three or above. Additionally, 50% were misidentified as human-written, suggesting AI's sophistication in mimicking human-generated content. A thematic analysis of open-ended feedback revealed that participants appreciated AI's empathy and personalized suggestions but found them more formulaic, less authentic, and too data-focused. This study reveals the preliminary feasibility and acceptability of LLM AIs, like ChatGPT, in crafting potentially effective weight control coaching messages. Our findings also underscore areas for future enhancement., Comment: 29 pages, 5 figures
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- 2023
35. X-Ray Constraints on the Hot Gaseous Corona of Edge-on Late-type Galaxies in Virgo
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Hou, Meicun, He, Lin, Hu, Zhensong, Li, Zhiyuan, Jones, Christine, Forman, William, Su, Yuanyuan, Wang, Jing, and Ho, Luis C.
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Astrophysics - Astrophysics of Galaxies - Abstract
We present a systematic study of the putative hot gas corona around late-type galaxies (LTGs) residing in the Virgo cluster, based on archival Chandra observations. Our sample consists of 21 nearly edge-on galaxies representing a star formation rate (SFR) range of ($0.2-3\rm~M_\odot~yr^{-1}$) a stellar mass ($M_*$) range of $(0.2-10) \times 10^{10}\rm~M_{\odot}$, the majority of which have not been explored with high-sensitivity X-ray observations so far. Significant extraplanar diffuse X-ray (0.5-2 keV) emission is detected in only three LTGs, which are also the three galaxies with the highest SFR. A stacking analysis is performed for the remaining galaxies without individual detection, dividing the whole sample into two subsets based on SFR, stellar mass, or specific SFR. Only the high-SFR bin yields a significant detection, which has a value of $L\rm_X \sim3\times10^{38}\rm~erg~s^{-1}$ per galaxy. The stacked extraplanar X-ray signals of the Virgo LTGs are consistent with the empirical $L\rm_X - SFR$ and $L\rm_X - M_*$ relations found among highly inclined disk galaxies in the field, but appear to be systematically lower than that of a comparison sample of simulated cluster star-formation galaxies identified from the Illustris-TNG100 simulation. The apparent paucity of hot gas coronae in the sampled Virgo LTGs might be understood as the net outcome of the long-lasting effect of ram pressure stripping exerted by the hot intra-cluster medium and in-disk star-forming activity acting on shorter timescales. A better understanding of the roles of environmental effects in regulating the hot gas content of cluster galaxies invites sensitive X-ray observations for a large galaxy sample., Comment: 18 pages, 7 figures. Accepted for publication in ApJ. Comments welcome
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- 2023
36. Pulsar-wind-nebula-powered Galactic center X-ray filament G0.13-0.11: Proof of the synchrotron nature by IXPE
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Churazov, Eugene, Khabibullin, Ildar, Barnouin, Thibault, Bucciantini, Niccolò, Costa, Enrico, Di Gesu, Laura, Di Marco, Alessandro, Ferrazzoli, Riccardo, Forman, William, Kaaret, Philip, Kim, Dawoon E., Kolodziejczak, Jeffery J., Kraft, Ralph, Marin, Frédéric, Matt, Giorgio, Negro, Michela, Romani, Roger W., Silvestri, Stefano, Soffitta, Paolo, Sunyaev, Rashid, Svoboda, Jiri, Vikhlinin, Alexey, Weisskopf, Martin C., Xie, Fei, Agudo, Iván, Antonelli, Lucio A., Bachetti, Matteo, Baldini, Luca, Baumgartner, Wayne H., Bellazzini, Ronaldo, Bianchi, Stefano, Bongiorno, Stephen D., Bonino, Raffaella, Brez, Alessandro, Capitanio, Fiamma, Castellano, Simone, Cavazzuti, Elisabetta, Chen, Chien-Ting, Ciprini, Stefano, De Rosa, Alessandra, Del Monte, Ettore, Di Lalla, Niccolò, Donnarumma, Immacolata, Doroshenko, Victor, Dovčiak, Michal, Ehlert, Steven R., Enoto, Teruaki, Evangelista, Yuri, Fabiani, Sergio, García, Javier A., Gunji, Shuichi, Hayashida, Kiyoshi, Heyl, Jeremy, Iwakiri, Wataru, Jorstad, Svetlana G., Karas, Vladimir, Kislat, Fabian, Kitaguchi, Takao, Krawczynski, Henric, La Monaca, Fabio, Latronico, Luca, Liodakis, Ioannis, Maldera, Simone, Manfreda, Alberto, Marinucci, Andrea, Marscher, Alan P., Marshall, Herman L., Massaro, Francesco, Mitsuishi, Ikuyuki, Mizuno, Tsunefumi, Muleri, Fabio, Ng, Chi-Yung, O'Dell, Stephen L., Omodei, Nicola, Oppedisano, Chiara, Papitto, Alessandro, Pavlov, George G., Peirson, Abel L., Perri, Matteo, Pesce-Rollins, Melissa, Petrucci, Pierre-Olivier, Pilia, Maura, Possenti, Andrea, Poutanen, Juri, Puccetti, Simonetta, Ramsey, Brian D., Rankin, John, Ratheesh, Ajay, Roberts, Oliver J., Sgrò, Carmelo, Slane, Patrick, Spandre, Gloria, Swartz, Douglas A., Tamagawa, Toru, Tavecchio, Fabrizio, Taverna, Roberto, Tawara, Yuzuru, Tennant, Allyn F., Thomas, Nicholas E., Tombesi, Francesco, Trois, Alessio, Tsygankov, Sergey S., Turolla, Roberto, Vink, Jacco, Wu, Kinwah, and Zane, Silvia
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
We report the discovery of X-ray polarization from the X-ray-bright filament. G0.13-0.11 in the Galactic center (GC) region. This filament features a bright, hard X-ray source that is most plausibly a pulsar wind nebula (PWN) and an extended and structured diffuse component. Combining the polarization signal from IXPE with the imaging/spectroscopic data from Chandra, we find that X-ray emission of G0.13-0.11 is highly polarized PD=$57(\pm18)$% in the 3-6 keV band, while the polarization angle is PA=$21^\circ(\pm9^\circ)$. This high degree of polarization proves the synchrotron origin of the X-ray emission from G0.13-0.11. In turn, the measured polarization angle implies that the X-ray emission is polarized approximately perpendicular to a sequence of nonthermal radio filaments that may be part of the GC Radio Arc. The magnetic field on the order of $100\,{\rm\mu G}$ appears to be preferentially ordered along the filaments. The above field strength is the fiducial value that makes our model self-consistent, while the other conclusions are largely model independent., Comment: Accepted for publication in A&A
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- 2023
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37. Jet reorientation in central galaxies of clusters and groups: insights from VLBA and Chandra data
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Ubertosi, Francesco, Schellenberger, Gerrit, O'Sullivan, Ewan, Vrtilek, Jan, Giacintucci, Simona, David, Laurence P., Forman, William, Gitti, Myriam, Venturi, Tiziana, Jones, Christine, and Brighenti, Fabrizio
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Astrophysics - Astrophysics of Galaxies - Abstract
Recent observations of galaxy clusters and groups with misalignments between their central AGN jets and X-ray cavities, or with multiple misaligned cavities, have raised concerns about the jet - bubble connection in cooling cores, and the processes responsible for jet realignment. To investigate the frequency and causes of such misalignments, we construct a sample of 16 cool core galaxy clusters and groups. Using VLBA radio data we measure the parsec-scale position angle of the jets, and compare it with the position angle of the X-ray cavities detected in Chandra data. Using the overall sample and selected subsets, we consistently find that there is a 30% - 38% chance to find a misalignment larger than $\Delta\Psi = 45^{\circ}$ when observing a cluster/group with a detected jet and at least one cavity. We determine that projection may account for an apparently large $\Delta\Psi$ only in a fraction of objects ($\sim$35%), and given that gas dynamical disturbances (as sloshing) are found in both aligned and misaligned systems, we exclude environmental perturbation as the main driver of cavity - jet misalignment. Moreover, we find that large misalignments (up to $\sim90^{\circ}$) are favored over smaller ones ($45^{\circ}\leq\Delta\Psi\leq70^{\circ}$), and that the change in jet direction can occur on timescales between one and a few tens of Myr. We conclude that misalignments are more likely related to actual reorientation of the jet axis, and we discuss several engine-based mechanisms that may cause these dramatic changes., Comment: Accepted for publication in ApJ
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- 2023
38. IS THE ROLLER COASTER RIDE NEARING AN END?
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Freedman, Dan, Forman, Jacob, Bardi, Jennifer, and Phillips, Noah
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Political parties -- Israel -- Palestinian Territories ,Ex-presidents -- Political aspects -- Political activity ,Ethnic, cultural, racial issues/studies ,General interest ,Democratic Party (United States) -- Political activity -- Political aspects - Abstract
When Moment began recruiting participants for its second Jewish Political Voices Project (JPVP) in the summer of 2023, the election season felt predetermined. President Joe Biden was the inevitable choice [...]
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- 2024
39. Bridging Innovation in Materials Selection and Design Education
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Ferreira, Pedro, Apolinário, Arlete, Forman, Gabriela, Tosi, Francesca, Editor-in-Chief, Germak, Claudio, Series Editor, Zurlo, Francesco, Series Editor, Jinyi, Zhi, Series Editor, Pozzatti Amadori, Marilaine, Series Editor, Caon, Maurizio, Series Editor, Raposo, Daniel, editor, Neves, João, editor, Silva, Ricardo, editor, Correia Castilho, Luísa, editor, and Dias, Rui, editor
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- 2025
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40. Diversity, Inequity, and Exclusion: How SATs and Other Standardized Tests Reduce Diversity in Higher Education
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Markson, Craig, Forman, Kenneth, Irizarry, Dafny, and Levy, Lawrence
- Abstract
The purpose of this study was to examine the relationships between race, high school graduation, Scholastic Aptitude Test (SAT) scores, and four-year college-going rates. The setting included 89 school districts that were located in two adjacent suburban counties in New York State: Nassau and Suffolk. A Pearson Product-Moment correlation analysis, with a two-tailed test of significance with an alpha set at 0.05, was used to analyze the relationships among the variables. The results indicated that Black or African American and Hispanic or Latino student populations had statistically significant and negative correlations with four-year college-going rates, SAT scores, and high school Advanced Regents graduation rates. Conversely, Asian and White student populations had statistically significant and positive correlations with these variables. Based on these findings, the researchers made specific recommendations for school districts, state education departments, and institutions of higher education to reduce the racial inequities in college-going rates.
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- 2023
41. Glutamate acts on acid-sensing ion channels to worsen ischaemic brain injury
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Lai, Ke, Pritišanac, Iva, Liu, Zhen-Qi, Liu, Han-Wei, Gong, Li-Na, Li, Ming-Xian, Lu, Jian-Fei, Qi, Xin, Xu, Tian-Le, Forman-Kay, Julie, Shi, Hai-Bo, Wang, Lu-Yang, and Yin, Shan-Kai
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- 2024
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42. Pre-frailty after blood or marrow transplantation and the risk of subsequent mortality
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Balas, Nora, Richman, Joshua S., Landier, Wendy, Shrestha, Sadeep, Bruxvoort, Katia J., Hageman, Lindsey, Meng, Qingrui, Ross, Elizabeth, Bosworth, Alysia, Wong, F. Lennie, Bhatia, Ravi, Forman, Stephen J., Armenian, Saro H., Weisdorf, Daniel J., and Bhatia, Smita
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- 2024
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43. PSCA-CAR T cell therapy in metastatic castration-resistant prostate cancer: a phase 1 trial
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Dorff, Tanya B., Blanchard, M. Suzette, Adkins, Lauren N., Luebbert, Laura, Leggett, Neena, Shishido, Stephanie N., Macias, Alan, Del Real, Marissa M., Dhapola, Gaurav, Egelston, Colt, Murad, John P., Rosa, Reginaldo, Paul, Jinny, Chaudhry, Ammar, Martirosyan, Hripsime, Gerdts, Ethan, Wagner, Jamie R., Stiller, Tracey, Tilakawardane, Dileshni, Pal, Sumanta, Martinez, Catalina, Reiter, Robert E., Budde, Lihua E., D’Apuzzo, Massimo, Kuhn, Peter, Pachter, Lior, Forman, Stephen J., and Priceman, Saul J.
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- 2024
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44. The Body of “the Body of Christ”: An Introduction to Hyperscanning Research and a Discussion of Its Possible Implications for Understanding Social Experiences During Religious Gatherings
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Forman, Robert K. C. and Wald-Fuhrmann, Melanie
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- 2024
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45. Ultra-Processed Food Addiction: A Research Update
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LaFata, Erica M., Allison, Kelly C., Audrain-McGovern, Janet, and Forman, Evan M.
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- 2024
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46. Psychological and behavioral responses to daily weight gain during behavioral weight loss treatment
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Hagerman, Charlotte J., Onu, Michael C., Crane, Nicole T., Butryn, Meghan L., and Forman, Evan. M.
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- 2024
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47. CHEX-MATE: Characterization of the intra-cluster medium temperature distribution
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Lovisari, L., Ettori, S., Rasia, E., Gaspari, M., Bourdin, H., Campitiello, M. G., Rossetti, M., Bartalucci, I., De Grandi, S., De Luca, F., De Petris, M., Eckert, D., Forman, W., Gastaldello, F., Ghizzardi, S., Jones, C., Kay, S., Kim, J., Maughan, B. J., Mazzotta, P., Pointecouteau, E., Pratt, G. W., Sayers, J., Sereno, M., Simonte, M., and Tozzi, P.
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Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
We study the perturbations in the temperature (and density) distribution for 28 clusters selected from the CHEX-MATE sample to evaluate and characterize the level of inhomogeneities and the related dynamical state of the ICM. We use these spatially resolved 2D distributions to measure the global and radial scatter and identify the regions that deviate the most from the average distribution. During this process, we introduce three dynamical state estimators and produce clean temperature profiles after removing the most deviant regions. We find that the temperature distribution of most of the clusters is skewed towards high temperatures and is well described by a log-normal function. There is no indication that the number of regions deviating more than 1$\sigma$ from the azimuthal value is correlated with the dynamical state inferred from morphological estimators. The removal of these regions leads to local temperature variations up to 10-20% and an average increase of $\sim$5% in the overall cluster temperatures. The measured relative intrinsic scatter within $R_{500}$, $\sigma_{T,int}/T$, has values of 0.17$^{+0.08}_{-0.05}$, and is almost independent of the cluster mass and dynamical state. Comparing the scatter of temperature and density profiles to hydrodynamic simulations, we constrain the average Mach number regime of the sample to $M_{3D}$=0.36$^{+0.16}_{-0.09}$. We infer the ratio between the energy in turbulence and the thermal energy, and translate this ratio in terms of a predicted hydrostatic mass bias $b$, estimating an average value of $b\sim$0.11 (covering a range between 0 and 0.37) within $R_{500}$. This study provides detailed temperature fluctuation measurements for 28 CHEX-MATE clusters which can be used to study turbulence, derive the mass bias, and make predictions on the scaling relation properties., Comment: Accepted for publication in A&A
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- 2023
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48. Weak-Lensing Analysis of the Complex Cluster Merger Abell 746 with Subaru/Hyper Suprime-Cam
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HyeongHan, Kim, Cho, Hyejeon, Jee, M. James, Wittman, David, Cha, Sangjun, Lee, Wonki, Finner, Kyle, Rajpurohit, Kamlesh, Brüggen, Marcus, Forman, William, Jones, Christine, van Weeren, Reinout, Botteon, Andrea, Lovisari, Lorenzo, Stroe, Andra, Domínguez-Fernández, Paola, O'Sullivan, Ewan, and Vrtilek, Jan
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Astrophysics - Astrophysics of Galaxies - Abstract
The galaxy cluster Abell 746 (A746; $z$=0.214), featuring a double radio relic system, two isolated radio relics, a possible radio halo, disturbed V-shaped X-ray emission, and intricate galaxy distributions, is a unique and complex merging system. We present a weak-lensing analysis of A746 based on wide-field imaging data from Subaru/Hyper Suprime-Cam observations. The mass distribution is characterized by a main peak which coincides with the center of the X-ray emission. At this main peak, we detect two extensions toward the north and west, tracing the cluster galaxy and X-ray distributions. Despite the ongoing merger, our estimate of the A746 global mass $M_{500}=4.4\pm1.0\times10^{14}~M_{\odot}$ is consistent with the previous results from SZ and X-ray observations. We conclude that reconciling the distributions of mass, galaxies, and intracluster medium with the double radio relic system and other radio features remains challenging., Comment: Published in ApJ
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- 2023
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49. LEM All-Sky Survey: Soft X-ray Sky at Microcalorimeter Resolution
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Khabibullin, Ildar, Galeazzi, Massimiliano, Bogdan, Akos, Cann, Jenna M., Churazov, Eugene, Dolag, Klaus, Drake, Jeremy J., Forman, William, Hernquist, Lars, Koutroumpa, Dimitra, Kraft, Ralph, Kuntz, K. D., Markevitch, Maxim, McCammon, Dan, Ogorzalek, Anna, Pfeifle, Ryan, Pillepich, Annalisa, Plucinsky, Paul P., Ponti, Gabriele, Schellenberger, Gerrit, Truong, Nhut, Valentini, Milena, Veilleux, Sylvain, Vladutescu-Zopp, Stephan, Wang, Q. Daniel, and Weaver, Kimberly
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Astrophysics of Galaxies ,Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Solar and Stellar Astrophysics - Abstract
The Line Emission Mapper (LEM) is an X-ray Probe with with spectral resolution ~2 eV FWHM from 0.2 to 2.5 keV and effective area >2,500 cm$^2$ at 1 keV, covering a 33 arcmin diameter Field of View with 15 arcsec angular resolution, capable of performing efficient scanning observations of very large sky areas and enabling the first high spectral resolution survey of the full sky. The LEM-All-Sky Survey (LASS) is expected to follow the success of previous all sky surveys such as ROSAT and eROSITA, adding a third dimension provided by the high resolution microcalorimeter spectrometer, with each 15 arcsec pixel of the survey including a full 1-2 eV resolution energy spectrum that can be integrated over any area of the sky to provide statistical accuracy. Like its predecessors, LASS will provide both a long-lasting legacy and open the door to the unknown, enabling new discoveries and delivering the baseline for unique GO studies. No other current or planned mission has the combination of microcalorimeter energy resolution and large grasp to cover the whole sky while maintaining good angular resolution and imaging capabilities. LASS will be able to probe the physical conditions of the hot phases of the Milky Way at multiple scales, from emission in the Solar system due to Solar Wind Charge eXchange, to the interstellar and circumgalactic media, including the North Polar Spur and the Fermi/eROSITA bubbles. It will measure velocities of gas in the inner part of the Galaxy and extract the emissivity of the Local Hot Bubble. By maintaining the original angular resolution, LASS will also be able to study classes of point sources through stacking. For classes with ~$10^4$ objects, it will provide the equivalent of 1 Ms of high spectral resolution data. We describe the technical specifications of LASS and highlight the main scientific objectives that will be addressed. (Abridged), Comment: White Paper in support of a mission concept to be submitted for the 2023 NASA Astrophysics Probes opportunity. This White Paper will be updated when required. 30 pages, 25 figures
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- 2023
50. Exploring chemical enrichment of the intracluster medium with the Line Emission Mapper
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Mernier, François, Su, Yuanyuan, Markevitch, Maxim, Zhang, Congyao, Simionescu, Aurora, Rasia, Elena, Lin, Sheng-Chieh, Zhuravleva, Irina, Sarkar, Arnab, Kraft, Ralph P., Ogorzalek, Anna, Ayromlou, Mohammadreza, Forman, William R., Jones, Christine, Bregman, Joel N., Ettori, Stefano, Dolag, Klaus, Biffi, Veronica, Churazov, Eugene, Sun, Ming, ZuHone, John, Bogdán, Ákos, Khabibullin, Ildar I., Werner, Norbert, Truong, Nhut, Chakraborty, Priyanka, Walker, Stephen A., Vogelsberger, Mark, Pillepich, Annalisa, and Mirakhor, Mohammad S.
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
Synthesized in the cores of stars and supernovae, most metals disperse over cosmic scales and are ultimately deposited well outside the gravitational potential of their host galaxies. Since their presence is well visible through their X-ray emission lines in the hot gas pervading galaxy clusters, measuring metal abundances in the intracluster medium (ICM) offers us a unique view of chemical enrichment of the Universe as a whole. Despite extraordinary progress in the field thanks to four decades of X-ray spectroscopy using CCD (and gratings) instruments, understanding the precise stellar origins of the bulk of metals, and when the latter were mixed on Mpc scales, requires an X-ray mission capable of spatial, non-dispersive high resolution spectroscopy covering at least the soft X-ray band over a large field of view. In this White Paper, we demonstrate how the Line Emission Mapper (LEM) probe mission concept will revolutionize our current picture of the ICM enrichment. Specifically, we show that LEM will be able to (i) spatially map the distribution of ten key chemical elements out to the virial radius of a nearby relaxed cluster and (ii) measure metal abundances in serendipitously discovered high-redshift protoclusters. Altogether, these key observables will allow us to constrain the chemical history of the largest gravitationally bound structures of the Universe. They will also solve key questions such as the universality of the initial mass function (IMF) and the initial metallicity of the stellar populations producing these metals, as well as the relative contribution of asymptotic giant branch (AGB) stars, core-collapse, and Type Ia supernovae to enrich the cosmic web over Mpc scales. Concrete observing strategies are also briefly discussed., Comment: 19 pages. White paper for a mission concept to be submitted for the 2023 NASA Astrophysics Probes opportunity
- Published
- 2023
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