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Objective: in this paper we propose a system to detect a subject's sympathetic reaction, which is related to unexpected or challenging events during a car drive., Methods: we use the Electrocardiogram (ECG) signal and the Skin Potential Response (SPR) signal, which has several advantages with respect to other Electrodermal (EDA) signals. We record one SPR signal for each hand, and use an algorithm that, selecting the smoother signal, is able to remove motion artifacts. We extract statistical features from the ECG and SPR signals in order to classify signal segments and identify the presence or absence of emotional events via a Supervised Learning Algorithm. The experiments were carried out in a company which specializes in driving simulator equipment, using a motorized platform and a driving simulator. Different subjects were tested with this setup, with different challenging events happening on predetermined locations on the track., Results: we obtain an Accuracy as high as 79.10% for signal blocks and as high as 91.27% for events., Conclusion: results demonstrate the good performance of the presented system in detecting sympathetic reactions, and the effectiveness of the motion artifact removal procedure., Significance: our work demonstrates the possibility to classify the emotional state of the driver, using the ECG and EDA signals and a slightly invasive setup. In particular, the proposed use of SPR and of the motion artifact removal procedure are crucial for the effectiveness of the system.