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Your search keyword '"Forde-Thomas, Josephine E."' showing total 9 results
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9 results on '"Forde-Thomas, Josephine E."'

3. Modified Hederagenin Derivatives Demonstrate Ex Vivo Anthelmintic Activity against Fasciola hepatica

Author

Chakroborty, Anand, primary, Pritchard, Deiniol R., additional, Bouillon, Marc E., additional, Cervi, Anna, additional, Kraehenbuehl, Rolf, additional, Wild, Charlotte, additional, Fenn, Caroline, additional, Holdsworth, Peter, additional, Capner, Colin, additional, Padalino, Gilda, additional, Forde-Thomas, Josephine E., additional, Payne, Joseph, additional, Smith, Brendan G., additional, Fisher, Maggie, additional, Lahmann, Martina, additional, Baird, Mark S., additional, and Hoffmann, Karl F., additional

Published
2023
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5. Schistosoma mansoni α-N-acetylgalactosaminidase (SmNAGAL) regulates coordinated parasite movement and egg production

Author

Hulme, Benjamin J., primary, Geyer, Kathrin K., additional, Forde-Thomas, Josephine E., additional, Padalino, Gilda, additional, Phillips, Dylan W., additional, Ittiprasert, Wannaporn, additional, Karinshak, Shannon E., additional, Mann, Victoria H., additional, Chalmers, Iain W., additional, Brindley, Paul J., additional, Hokke, Cornelis H., additional, and Hoffmann, Karl F., additional

Published
2022
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6. Schistosoma mansoni Larval Extracellular Vesicle protein 1 (SmLEV1) is an immunogenic antigen found in EVs released from pre-acetabular glands of invading cercariae

Author

Gasan, Thomas A., primary, Kuipers, Marije E., additional, Roberts, Grisial H., additional, Padalino, Gilda, additional, Forde-Thomas, Josephine E., additional, Wilson, Shona, additional, Wawrzyniak, Jakub, additional, Tukahebwa, Edridah M., additional, Hoffmann, Karl F., additional, and Chalmers, Iain W., additional

Published
2021
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7. Schistosoma mansoni α-N-acetylgalactosaminidase (SmNAGAL) regulates coordinated parasite movement and egg production

Author

Hulme, Benjamin J., primary, Geyer, Kathrin K., additional, Forde-Thomas, Josephine E., additional, Padalino, Gilda, additional, Phillips, Dylan W., additional, Ittiprasert, Wannaporn, additional, Karinshak, Shannon E., additional, Mann, Victoria H., additional, Chalmers, Iain W., additional, Brindley, Paul J., additional, Hokke, Cornelis H., additional, and Hoffmann, Karl F., additional

Published
2021
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9. Aberrant spindle dynamics and cytokinesis in Dictyostelium discoideum cells that lack glycogen synthase kinase 3☆

Author

Harwood, Adrian J., Forde-Thomas, Josephine E., Williams, Hazel, Samereier, Matthias, and Müller-Taubenberger, Annette

Subjects
Glycogen Synthase Kinase 3, Short Communication, Chromosome Segregation, Mitotic spindle, Mutation, Protozoan Proteins, Mitosis, Dictyostelium, macromolecular substances, Spindle Apparatus, Cytokinesis, Protein Binding
Abstract

Eukaryotic cell division requires the co-ordinated assembly and disassembly of the mitotic spindle, accurate chromosome segregation and temporal control of cytokinesis to generate two daughter cells. While the absolute details of these processes differ between organisms, there are evolutionarily conserved core components common to all eukaryotic cells, whose identification will reveal the key processes that control cell division. Glycogen synthase kinase 3 (GSK-3) is a major protein kinase found throughout the eukaryotes and regulates many processes, including cell differentiation, growth, motility and apoptosis. In animals, GSK-3 associates with mitotic spindles and its inhibition causes mis-regulation of chromosome segregation. Two suppressor screens in yeast point to a more general effect of GSK-3 on cell division, however the direct role of GSK-3 in control of mitosis has not been explored outside the animal kingdom. Here we report that the Dictyostelium discoideum GSK-3 orthologue, GskA, associates with the mitotic spindle during cell division, as seen for its mammalian counterparts. Dictyostelium possesses only a single GSK-3 gene that can be deleted to eliminate all GSK-3 activity. We found that gskA-null mutants failed to elongate their mitotic spindle and were unable to divide in shaking culture, but have no chromosome segregation defect. These results suggest further conservation for the role of GSK-3 in the regulation of spindle dynamics during mitosis, but also reveal differences in the mechanisms ensuring accurate chromosome segregation.

Published
2013

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