203 results on '"Ford, J.M."'
Search Results
2. A method for estimating and characterizing explicitly nonlinear dynamic functional network connectivity in resting-state fMRI data
- Author
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Motlaghian, S.M., primary, Vahidi, V., additional, Belger, A., additional, Bustillo, J.R., additional, Faghiri, A., additional, Ford, J.M., additional, Iraji, A., additional, Lim, K., additional, Mathalon, D.H., additional, Miller, R., additional, Mueller, B.A., additional, O'Leary, D., additional, Potkin, S.G., additional, Preda, A., additional, van Erp, T.G., additional, and Calhoun, V.D., additional
- Published
- 2023
- Full Text
- View/download PDF
3. Large-scale analysis of structural brain asymmetries in schizophrenia via the ENIGMA consortium.
- Author
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Schijven, Dick, Postema, M.C., Fukunaga, M., Matsumoto, J., Miura, K., Zwarte, S.M.C. de, Haren, N.E.M. van, Cahn, W., Hulshoff Pol, H.E., Kahn, R.S., Ayesa-Arriola, R., Ortoz-García de la Foz, V., Tordesillas-Gutierrez, D., Vázquez-Bourgon, J., Crespo-Facorro, B., Alnæs, D., Dahl, A., Westlye, L.T., Agartz, I., Andreassen, O.A., Jönsson, E.G., Kochunov, P., Bruggemann, J.M., Catts, S.V., Michie, P.T., Mowry, B.J., Quidé, Y., Rasser, P.E., Schall, U., Scott, R.J., Carr, V.J., Green, M.J., Henskens, F.A., Loughland, C.M., Pantelis, C., Weickert, C.S., Weickert, T.W., Haan, L. de, Brosch, K., Pfarr, J.K., Ringwald, K.G., Stein, F., Jansen, Andreas, Kircher, T.T.J., Nenadić, I., Krämer, Bernd, Gruber, O., Satterthwaite, T.D., Bustillo, J., Mathalon, D.H., Preda, A., Calhoun, V.D., Ford, J.M., Potkin, S.G., Chen, Jingxu, Tan, Yunlong, Wang, Zhiren, Xiang, Hong, Fan, Fengmei, Bernardoni, F., Ehrlich, S., Fuentes-Claramonte, P., Garcia-Leon, M.A., Guerrero-Pedraza, A., Salvador, R., Sarró, S., Pomarol-Clotet, E., Ciullo, V., Piras, F., Vecchio, D., Banaj, N., Spalletta, G., Michielse, S., Amelsvoort, T. van, Dickie, E.W., Voineskos, A.N., Sim, K., Ciufolini, S., Dazzan, P., Murray, R.M., Kim, W.S., Chung, Y.C., Andreou, C., Schmidt, A, Borgwardt, S., McIntosh, A.M., Whalley, H.C., Lawrie, S.M., Plessis, S. du, Luckhoff, H.K., Scheffler, F., Emsley, R., Grotegerd, D., Lencer, R., Dannlowski, U., Edmond, J.T., Rootes-Murdy, K., Stephen, J.M., Mayer, A.R., Antonucci, L.A., Fazio, L., Pergola, G., Bertolino, A., Díaz-Caneja, C.M., Janssen, J, Lois, N.G., Arango, C., Tomyshev, A.S., Lebedeva, I., Cervenka, S., Sellgren, C.M., Georgiadis, F., Kirschner, M., Kaiser, S., Hajek, T., Skoch, A., Spaniel, F., Kim, M., Kwak, Y.B., Oh, S., Kwon, J.S., James, A., Bakker, G., Knöchel, C., Stäblein, M., Oertel, V., Uhlmann, A., Howells, F.M., Stein, D.J., Temmingh, H.S., Diaz-Zuluaga, A.M., Pineda-Zapata, J.A., López-Jaramillo, C., Homan, S., Ji, E., Surbeck, W., Homan, P., Fisher, S.E., Franke, B., Glahn, D.C., Gur, R.C., Hashimoto, R., Jahanshad, N., Luders, E., Medland, S.E., Thompson, P.M., Turner, J.A., Erp, T.G. van, Francks, C., Schijven, Dick, Postema, M.C., Fukunaga, M., Matsumoto, J., Miura, K., Zwarte, S.M.C. de, Haren, N.E.M. van, Cahn, W., Hulshoff Pol, H.E., Kahn, R.S., Ayesa-Arriola, R., Ortoz-García de la Foz, V., Tordesillas-Gutierrez, D., Vázquez-Bourgon, J., Crespo-Facorro, B., Alnæs, D., Dahl, A., Westlye, L.T., Agartz, I., Andreassen, O.A., Jönsson, E.G., Kochunov, P., Bruggemann, J.M., Catts, S.V., Michie, P.T., Mowry, B.J., Quidé, Y., Rasser, P.E., Schall, U., Scott, R.J., Carr, V.J., Green, M.J., Henskens, F.A., Loughland, C.M., Pantelis, C., Weickert, C.S., Weickert, T.W., Haan, L. de, Brosch, K., Pfarr, J.K., Ringwald, K.G., Stein, F., Jansen, Andreas, Kircher, T.T.J., Nenadić, I., Krämer, Bernd, Gruber, O., Satterthwaite, T.D., Bustillo, J., Mathalon, D.H., Preda, A., Calhoun, V.D., Ford, J.M., Potkin, S.G., Chen, Jingxu, Tan, Yunlong, Wang, Zhiren, Xiang, Hong, Fan, Fengmei, Bernardoni, F., Ehrlich, S., Fuentes-Claramonte, P., Garcia-Leon, M.A., Guerrero-Pedraza, A., Salvador, R., Sarró, S., Pomarol-Clotet, E., Ciullo, V., Piras, F., Vecchio, D., Banaj, N., Spalletta, G., Michielse, S., Amelsvoort, T. van, Dickie, E.W., Voineskos, A.N., Sim, K., Ciufolini, S., Dazzan, P., Murray, R.M., Kim, W.S., Chung, Y.C., Andreou, C., Schmidt, A, Borgwardt, S., McIntosh, A.M., Whalley, H.C., Lawrie, S.M., Plessis, S. du, Luckhoff, H.K., Scheffler, F., Emsley, R., Grotegerd, D., Lencer, R., Dannlowski, U., Edmond, J.T., Rootes-Murdy, K., Stephen, J.M., Mayer, A.R., Antonucci, L.A., Fazio, L., Pergola, G., Bertolino, A., Díaz-Caneja, C.M., Janssen, J, Lois, N.G., Arango, C., Tomyshev, A.S., Lebedeva, I., Cervenka, S., Sellgren, C.M., Georgiadis, F., Kirschner, M., Kaiser, S., Hajek, T., Skoch, A., Spaniel, F., Kim, M., Kwak, Y.B., Oh, S., Kwon, J.S., James, A., Bakker, G., Knöchel, C., Stäblein, M., Oertel, V., Uhlmann, A., Howells, F.M., Stein, D.J., Temmingh, H.S., Diaz-Zuluaga, A.M., Pineda-Zapata, J.A., López-Jaramillo, C., Homan, S., Ji, E., Surbeck, W., Homan, P., Fisher, S.E., Franke, B., Glahn, D.C., Gur, R.C., Hashimoto, R., Jahanshad, N., Luders, E., Medland, S.E., Thompson, P.M., Turner, J.A., Erp, T.G. van, and Francks, C.
- Abstract
Item does not contain fulltext, Left-right asymmetry is an important organizing feature of the healthy brain that may be altered in schizophrenia, but most studies have used relatively small samples and heterogeneous approaches, resulting in equivocal findings. We carried out the largest case-control study of structural brain asymmetries in schizophrenia, with MRI data from 5,080 affected individuals and 6,015 controls across 46 datasets, using a single image analysis protocol. Asymmetry indexes were calculated for global and regional cortical thickness, surface area, and subcortical volume measures. Differences of asymmetry were calculated between affected individuals and controls per dataset, and effect sizes were meta-analyzed across datasets. Small average case-control differences were observed for thickness asymmetries of the rostral anterior cingulate and the middle temporal gyrus, both driven by thinner left-hemispheric cortices in schizophrenia. Analyses of these asymmetries with respect to the use of antipsychotic medication and other clinical variables did not show any significant associations. Assessment of age- and sex-specific effects revealed a stronger average leftward asymmetry of pallidum volume between older cases and controls. Case-control differences in a multivariate context were assessed in a subset of the data (N = 2,029), which revealed that 7% of the variance across all structural asymmetries was explained by case-control status. Subtle case-control differences of brain macrostructural asymmetry may reflect differences at the molecular, cytoarchitectonic, or circuit levels that have functional relevance for the disorder. Reduced left middle temporal cortical thickness is consistent with altered left-hemisphere language network organization in schizophrenia.
- Published
- 2023
4. Oxytocin administration selectively improves olfactory detection thresholds for lyral in patients with schizophrenia
- Author
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Woolley, J.D., Lam, O., Chuang, B., Ford, J.M., Mathalon, D.H., and Vinogradov, S.
- Published
- 2015
- Full Text
- View/download PDF
5. Canonical and Replicable Multi-Scale Intrinsic Connectivity Networks in 100k+ Resting-State fMRI Datasets
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Iraji, A., primary, Fu, Z., additional, Faghiri, A., additional, Duda, M., additional, Chen, J., additional, Rachakonda, S., additional, DeRamus, T., additional, Kochunov, P., additional, Adhikari, B. M., additional, Belger, A., additional, Ford, J.M., additional, Mathalon, D.H., additional, Pearlson, G.D., additional, Potkin, S.G., additional, Preda, A., additional, Turner, J.A., additional, van Erp, T.G.M., additional, Bustillo, J. R., additional, Yang, K., additional, Ishizuka, K., additional, Sawa, A., additional, Hutchison, K., additional, Osuch, E. A., additional, Theberge, Jean, additional, Abbott, C., additional, Mueller, B.A., additional, Zhi, D., additional, Zhuo, C., additional, Liu, S., additional, Xu, Y., additional, Salman, M., additional, Liu, J., additional, Du, Y., additional, Sui, J., additional, Adali, T., additional, and Calhoun, V.D., additional
- Published
- 2022
- Full Text
- View/download PDF
6. Virtual Ontogeny of Cortical Growth Preceding Mental Illness
- Author
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Patel, Y., Shin, J., Abé, C., Agartz, I., Alloza, C., Alnæs, D., Ambrogi, S., Antonucci, L.A., Arango, C., Arolt, V., Auzias, G., Ayesa-Arriola, R., Banaj, N., Banaschewski, T., Bandeira, C., Başgöze, Z., Cupertino, R.B., Bau, C.H.D., Bauer, J., Baumeister, S., Bernardoni, F., Bertolino, A., Bonnin, C.D.M., Brandeis, D., Brem, S., Bruggemann, J., Bülow, R., Bustillo, J.R., Calderoni, S., Calvo, R., Canales-Rodríguez, E.J., Cannon, D.M., Carmona, S., Carr, V.J., Catts, S.V., Chenji, S., Chew, Q.H., Coghill, D., Connolly, C.G., Conzelmann, A., Craven, A.R., Crespo-Facorro, B., Cullen, K., Dahl, A., Dannlowski, U., Davey, C.G., Deruelle, C., Díaz-Caneja, C.M., Dohm, K., Ehrlich, S., Epstein, J., Erwin-Grabner, T., Eyler, L.T., Fedor, J., Fitzgerald, J., Foran, W., Ford, J.M., Fortea, L., Fuentes-Claramonte, P., Fullerton, J., Furlong, L., Gallagher, L., Gao, B., Gao, S., Goikolea, J.M., Gotlib, I., Goya-Maldonado, R., Grabe, H.J., Green, M., Grevet, E.H., Groenewold, N.A., Grotegerd, D., Gruber, O., Haavik, J., Hahn, T., Harrison, B.J., Heindel, W., Henskens, F., Heslenfeld, D.J., Hilland, E., Hoekstra, P.J., Hohmann, S., Holz, N., Howells, F.M., Ipser, J.C., Jahanshad, N., Jakobi, B., Jansen, A, Janssen, J., Jonassen, R., Kaiser, A., Kaleda, V., Karantonis, J., King, J.A., Kircher, T., Kochunov, P., Koopowitz, S.M., Landén, M., Landrø, N.I., Hoogman, M., Lawrie, S., Franke, B., Rooij, D. van, Buitelaar, J.K., Thompson, P., Paus, T., Patel, Y., Shin, J., Abé, C., Agartz, I., Alloza, C., Alnæs, D., Ambrogi, S., Antonucci, L.A., Arango, C., Arolt, V., Auzias, G., Ayesa-Arriola, R., Banaj, N., Banaschewski, T., Bandeira, C., Başgöze, Z., Cupertino, R.B., Bau, C.H.D., Bauer, J., Baumeister, S., Bernardoni, F., Bertolino, A., Bonnin, C.D.M., Brandeis, D., Brem, S., Bruggemann, J., Bülow, R., Bustillo, J.R., Calderoni, S., Calvo, R., Canales-Rodríguez, E.J., Cannon, D.M., Carmona, S., Carr, V.J., Catts, S.V., Chenji, S., Chew, Q.H., Coghill, D., Connolly, C.G., Conzelmann, A., Craven, A.R., Crespo-Facorro, B., Cullen, K., Dahl, A., Dannlowski, U., Davey, C.G., Deruelle, C., Díaz-Caneja, C.M., Dohm, K., Ehrlich, S., Epstein, J., Erwin-Grabner, T., Eyler, L.T., Fedor, J., Fitzgerald, J., Foran, W., Ford, J.M., Fortea, L., Fuentes-Claramonte, P., Fullerton, J., Furlong, L., Gallagher, L., Gao, B., Gao, S., Goikolea, J.M., Gotlib, I., Goya-Maldonado, R., Grabe, H.J., Green, M., Grevet, E.H., Groenewold, N.A., Grotegerd, D., Gruber, O., Haavik, J., Hahn, T., Harrison, B.J., Heindel, W., Henskens, F., Heslenfeld, D.J., Hilland, E., Hoekstra, P.J., Hohmann, S., Holz, N., Howells, F.M., Ipser, J.C., Jahanshad, N., Jakobi, B., Jansen, A, Janssen, J., Jonassen, R., Kaiser, A., Kaleda, V., Karantonis, J., King, J.A., Kircher, T., Kochunov, P., Koopowitz, S.M., Landén, M., Landrø, N.I., Hoogman, M., Lawrie, S., Franke, B., Rooij, D. van, Buitelaar, J.K., Thompson, P., and Paus, T.
- Abstract
Contains fulltext : 281502.pdf (Publisher’s version ) (Closed access), BACKGROUND: Morphology of the human cerebral cortex differs across psychiatric disorders, with neurobiology and developmental origins mostly undetermined. Deviations in the tangential growth of the cerebral cortex during pre/perinatal periods may be reflected in individual variations in cortical surface area later in life. METHODS: Interregional profiles of group differences in surface area between cases and controls were generated using T1-weighted magnetic resonance imaging from 27,359 individuals including those with attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depressive disorder, schizophrenia, and high general psychopathology (through the Child Behavior Checklist). Similarity of interregional profiles of group differences in surface area and prenatal cell-specific gene expression was assessed. RESULTS: Across the 11 cortical regions, group differences in cortical area for attention-deficit/hyperactivity disorder, schizophrenia, and Child Behavior Checklist were dominant in multimodal association cortices. The same interregional profiles were also associated with interregional profiles of (prenatal) gene expression specific to proliferative cells, namely radial glia and intermediate progenitor cells (greater expression, larger difference), as well as differentiated cells, namely excitatory neurons and endothelial and mural cells (greater expression, smaller difference). Finally, these cell types were implicated in known pre/perinatal risk factors for psychosis. Genes coexpressed with radial glia were enriched with genes implicated in congenital abnormalities, birth weight, hypoxia, and starvation. Genes coexpressed with endothelial and mural genes were enriched with genes associated with maternal hypertension and preterm birth. CONCLUSIONS: Our findings support a neurodevelopmental model of vulnerability to mental illness whereby prenatal risk factors acting through cell-specific processes lead to deviations from t
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- 2022
7. Moving Beyond the ‘CAP’ of the Iceberg: Intrinsic Connectivity Networks in fMRI are Continuously Engaging and Overlapping
- Author
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Iraji, A., primary, Faghiri, A., additional, Fu, Z., additional, Kochunov, P., additional, Adhikari, B. M., additional, Belger, A., additional, Ford, J.M., additional, McEwen, S., additional, Mathalon, D.H., additional, Pearlson, G.D., additional, Potkin, S.G., additional, Preda, A., additional, Turner, J.A., additional, van Erp, T.G.M., additional, Chang, C., additional, and Calhoun, V.D., additional
- Published
- 2021
- Full Text
- View/download PDF
8. Virtual Histology of Cortical Thickness and Shared Neurobiology in 6 Psychiatric Disorders
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Patel, Y., Parker, N., Shin, J., Howard, D., French, L., Thomopoulos, S.I., Pozzi, E., Abe, Y., Abé, C., Anticevic, A., Alda, M., Aleman, A., Alloza, C., Alonso-Lana, S., Ameis, S.H., Anagnostou, E., McIntosh, A.A., Arango, C., Arnold, P.D., Asherson, P., Assogna, F., Auzias, G., Ayesa-Arriola, R., Bakker, G., Banaj, N., Banaschewski, T., Bandeira, C.E., Baranov, A., Bargalló, N., Bau, C.H.D., Baumeister, S., Baune, B.T., Bellgrove, M.A., Benedetti, F., Bertolino, A., Boedhoe, P.S.W., Boks, M., Bollettini, I., Del Mar Bonnin, C., Borgers, T., Borgwardt, S., Brandeis, D., Brennan, B.P., Bruggemann, J.M., Bülow, R., Busatto, G.F., Calderoni, S., Calhoun, V.D., Calvo, R., Canales-Rodríguez, E.J., Cannon, D.M., Carr, V.J., Cascella, N., Cercignani, M., Chaim-Avancini, T.M., Christakou, A., Coghill, D., Conzelmann, A., Crespo-Facorro, B., Cubillo, A.I., Cullen, K.R., Cupertino, R.B., Daly, E., Dannlowski, U., Davey, C.G., Denys, D., Deruelle, C., Di Giorgio, A., Dickie, E.W., Dima, D., Dohm, K., Ehrlich, S., Ely, B.A., Erwin-Grabner, T., Ethofer, T., Fair, D.A., Fallgatter, A.J., Faraone, S.V., Fatjó-Vilas, M., Fedor, J.M., Fitzgerald, K.D., Ford, J.M., Frodl, T., Fu, C.H.Y., Fullerton, J.M., Gabel, M.C., Glahn, D.C., Roberts, G., Gogberashvili, T., Goikolea, J.M., Gotlib, I.H., Goya-Maldonado, R., Grabe, H.J., Green, M.J., Grevet, E.H., Groenewold, N.A., Grotegerd, D., Gruber, O., Gruner, P., Guerrero-Pedraza, A., Gur, R.E., Gur, R.C., Haar, S., Haarman, B.C.M., Haavik, J., Hahn, T., Hajek, T., Harrison, B.J., Harrison, N.A., Hartman, C.A., Whalley, H.C., Heslenfeld, D.J., Hibar, D.P., Hilland, E., Hirano, Y., Ho, T.C., Hoekstra, P.J., Hoekstra, L., Hohmann, S., Hong, L.E., Höschl, C., Høvik, M.F., Howells, F.M., Nenadic, I., Jalbrzikowski, M., James, A.C., Janssen, J., Jaspers-Fayer, F., Xu, J., Jonassen, R., Karkashadze, G., King, J.A., Kircher, T., Kirschner, M., Koch, K., Kochunov, P., Kohls, G., Konrad, K., Krämer, B., Krug, A., Kuntsi, J., Kwon, J.S., Landén, M., Landrø, N.I., Lazaro, L., Lebedeva, I.S., Leehr, E.J., Lera-Miguel, S., Lesch, K.-P., Lochner, C., Louza, M.R., Luna, B., Lundervold, A.J., Macmaster, F.P., Maglanoc, L.A., Malpas, C.B., Portella, M.J., Marsh, R., Martyn, F.M., Mataix-Cols, D., Mathalon, D.H., McCarthy, H., McDonald, C., McPhilemy, G., Meinert, S., Menchón, J.M., Minuzzi, L., Mitchell, P.B., Moreno, C., Morgado, P., Muratori, F., Murphy, C.M., Murphy, D., Mwangi, B., Nabulsi, L., Nakagawa, A., Nakamae, T., Namazova, L., Narayanaswamy, J., Jahanshad, N., Nguyen, D.D., Nicolau, R., O'Gorman Tuura, R.L., O'Hearn, K., Oosterlaan, J., Opel, N., Ophoff, R.A., Oranje, B., García De La Foz, V.O., Overs, B.J., Paloyelis, Y., Pantelis, C., Parellada, M., Pauli, P., Picó-Pérez, M., Picon, F.A., Piras, F., Plessen, K.J., Pomarol-Clotet, E., Preda, A., Puig, O., Quidé, Y., Radua, J., Ramos-Quiroga, J.A., Rasser, P.E., Rauer, L., Reddy, J., Redlich, R., Reif, A., Reneman, L., Repple, J., Retico, A., Richarte, V., Richter, A., Rosa, P.G.P., Rubia, K.K., Hashimoto, R., Sacchet, M.D., Salvador, R., Santonja, J., Sarink, K., Sarró, S., Satterthwaite, T.D., Sawa, A., Schall, U., Schofield, P.R., Schrantee, A., Seitz, J., Serpa, M.H., Setién-Suero, E., Shaw, P., Shook, D., Silk, T.J., Sim, K., Simon, S., Simpson, H.B., Singh, A., Skoch, A., Skokauskas, N., Soares, J.C., Soreni, N., Soriano-Mas, C., Spalletta, G., Spaniel, F., Lawrie, S.M., Stern, E.R., Stewart, S.E., Takayanagi, Y., Temmingh, H.S., Tolin, D.F., Tomecek, D., Tordesillas-Gutiérrez, D., Tosetti, M., Uhlmann, A., Van Amelsvoort, T., Van Der Wee, N.J.A., Van Der Werff, S.J.A., Van Haren, N.E.M., Van Wingen, G.A., Vance, A., Vázquez-Bourgon, J., Vecchio, D., Venkatasubramanian, G., Vieta, E., Vilarroya, O., Vives-Gilabert, Y., Voineskos, A.N., Völzke, H., Von Polier, G.G., Walton, E., Weickert, T.W., Weickert, C.S., Weideman, A.S., Wittfeld, K., Wolf, D.H., Wu, M.-J., Yang, T.T., Yang, K., Yoncheva, Y., Yun, J.-Y., Cheng, Y., Zanetti, M.V., Ziegler, G.C., Franke, B., Hoogman, M., Buitelaar, J.K., Van Rooij, D., Andreassen, O.A., Ching, C.R.K., Veltman, D.J., Schmaal, L., Stein, D.J., Van Den Heuvel, O.A., Turner, J.A., Van Erp, T.G.M., Pausova, Z., Thompson, P.M., Paus, T., Patel, Y., Parker, N., Shin, J., Howard, D., French, L., Thomopoulos, S.I., Pozzi, E., Abe, Y., Abé, C., Anticevic, A., Alda, M., Aleman, A., Alloza, C., Alonso-Lana, S., Ameis, S.H., Anagnostou, E., McIntosh, A.A., Arango, C., Arnold, P.D., Asherson, P., Assogna, F., Auzias, G., Ayesa-Arriola, R., Bakker, G., Banaj, N., Banaschewski, T., Bandeira, C.E., Baranov, A., Bargalló, N., Bau, C.H.D., Baumeister, S., Baune, B.T., Bellgrove, M.A., Benedetti, F., Bertolino, A., Boedhoe, P.S.W., Boks, M., Bollettini, I., Del Mar Bonnin, C., Borgers, T., Borgwardt, S., Brandeis, D., Brennan, B.P., Bruggemann, J.M., Bülow, R., Busatto, G.F., Calderoni, S., Calhoun, V.D., Calvo, R., Canales-Rodríguez, E.J., Cannon, D.M., Carr, V.J., Cascella, N., Cercignani, M., Chaim-Avancini, T.M., Christakou, A., Coghill, D., Conzelmann, A., Crespo-Facorro, B., Cubillo, A.I., Cullen, K.R., Cupertino, R.B., Daly, E., Dannlowski, U., Davey, C.G., Denys, D., Deruelle, C., Di Giorgio, A., Dickie, E.W., Dima, D., Dohm, K., Ehrlich, S., Ely, B.A., Erwin-Grabner, T., Ethofer, T., Fair, D.A., Fallgatter, A.J., Faraone, S.V., Fatjó-Vilas, M., Fedor, J.M., Fitzgerald, K.D., Ford, J.M., Frodl, T., Fu, C.H.Y., Fullerton, J.M., Gabel, M.C., Glahn, D.C., Roberts, G., Gogberashvili, T., Goikolea, J.M., Gotlib, I.H., Goya-Maldonado, R., Grabe, H.J., Green, M.J., Grevet, E.H., Groenewold, N.A., Grotegerd, D., Gruber, O., Gruner, P., Guerrero-Pedraza, A., Gur, R.E., Gur, R.C., Haar, S., Haarman, B.C.M., Haavik, J., Hahn, T., Hajek, T., Harrison, B.J., Harrison, N.A., Hartman, C.A., Whalley, H.C., Heslenfeld, D.J., Hibar, D.P., Hilland, E., Hirano, Y., Ho, T.C., Hoekstra, P.J., Hoekstra, L., Hohmann, S., Hong, L.E., Höschl, C., Høvik, M.F., Howells, F.M., Nenadic, I., Jalbrzikowski, M., James, A.C., Janssen, J., Jaspers-Fayer, F., Xu, J., Jonassen, R., Karkashadze, G., King, J.A., Kircher, T., Kirschner, M., Koch, K., Kochunov, P., Kohls, G., Konrad, K., Krämer, B., Krug, A., Kuntsi, J., Kwon, J.S., Landén, M., Landrø, N.I., Lazaro, L., Lebedeva, I.S., Leehr, E.J., Lera-Miguel, S., Lesch, K.-P., Lochner, C., Louza, M.R., Luna, B., Lundervold, A.J., Macmaster, F.P., Maglanoc, L.A., Malpas, C.B., Portella, M.J., Marsh, R., Martyn, F.M., Mataix-Cols, D., Mathalon, D.H., McCarthy, H., McDonald, C., McPhilemy, G., Meinert, S., Menchón, J.M., Minuzzi, L., Mitchell, P.B., Moreno, C., Morgado, P., Muratori, F., Murphy, C.M., Murphy, D., Mwangi, B., Nabulsi, L., Nakagawa, A., Nakamae, T., Namazova, L., Narayanaswamy, J., Jahanshad, N., Nguyen, D.D., Nicolau, R., O'Gorman Tuura, R.L., O'Hearn, K., Oosterlaan, J., Opel, N., Ophoff, R.A., Oranje, B., García De La Foz, V.O., Overs, B.J., Paloyelis, Y., Pantelis, C., Parellada, M., Pauli, P., Picó-Pérez, M., Picon, F.A., Piras, F., Plessen, K.J., Pomarol-Clotet, E., Preda, A., Puig, O., Quidé, Y., Radua, J., Ramos-Quiroga, J.A., Rasser, P.E., Rauer, L., Reddy, J., Redlich, R., Reif, A., Reneman, L., Repple, J., Retico, A., Richarte, V., Richter, A., Rosa, P.G.P., Rubia, K.K., Hashimoto, R., Sacchet, M.D., Salvador, R., Santonja, J., Sarink, K., Sarró, S., Satterthwaite, T.D., Sawa, A., Schall, U., Schofield, P.R., Schrantee, A., Seitz, J., Serpa, M.H., Setién-Suero, E., Shaw, P., Shook, D., Silk, T.J., Sim, K., Simon, S., Simpson, H.B., Singh, A., Skoch, A., Skokauskas, N., Soares, J.C., Soreni, N., Soriano-Mas, C., Spalletta, G., Spaniel, F., Lawrie, S.M., Stern, E.R., Stewart, S.E., Takayanagi, Y., Temmingh, H.S., Tolin, D.F., Tomecek, D., Tordesillas-Gutiérrez, D., Tosetti, M., Uhlmann, A., Van Amelsvoort, T., Van Der Wee, N.J.A., Van Der Werff, S.J.A., Van Haren, N.E.M., Van Wingen, G.A., Vance, A., Vázquez-Bourgon, J., Vecchio, D., Venkatasubramanian, G., Vieta, E., Vilarroya, O., Vives-Gilabert, Y., Voineskos, A.N., Völzke, H., Von Polier, G.G., Walton, E., Weickert, T.W., Weickert, C.S., Weideman, A.S., Wittfeld, K., Wolf, D.H., Wu, M.-J., Yang, T.T., Yang, K., Yoncheva, Y., Yun, J.-Y., Cheng, Y., Zanetti, M.V., Ziegler, G.C., Franke, B., Hoogman, M., Buitelaar, J.K., Van Rooij, D., Andreassen, O.A., Ching, C.R.K., Veltman, D.J., Schmaal, L., Stein, D.J., Van Den Heuvel, O.A., Turner, J.A., Van Erp, T.G.M., Pausova, Z., Thompson, P.M., and Paus, T.
- Abstract
Importance Large-scale neuroimaging studies have revealed group differences in cortical thickness across many psychiatric disorders. The underlying neurobiology behind these differences is not well understood. Objective To determine neurobiologic correlates of group differences in cortical thickness between cases and controls in 6 disorders: attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), bipolar disorder (BD), major depressive disorder (MDD), obsessive-compulsive disorder (OCD), and schizophrenia. Design, Setting, and Participants Profiles of group differences in cortical thickness between cases and controls were generated using T1-weighted magnetic resonance images. Similarity between interregional profiles of cell-specific gene expression and those in the group differences in cortical thickness were investigated in each disorder. Next, principal component analysis was used to reveal a shared profile of group difference in thickness across the disorders. Analysis for gene coexpression, clustering, and enrichment for genes associated with these disorders were conducted. Data analysis was conducted between June and December 2019. The analysis included 145 cohorts across 6 psychiatric disorders drawn from the ENIGMA consortium. The numbers of cases and controls in each of the 6 disorders were as follows: ADHD: 1814 and 1602; ASD: 1748 and 1770; BD: 1547 and 3405; MDD: 2658 and 3572; OCD: 2266 and 2007; and schizophrenia: 2688 and 3244. Main Outcomes and Measures Interregional profiles of group difference in cortical thickness between cases and controls. Results A total of 12 721 cases and 15 600 controls, ranging from ages 2 to 89 years, were included in this study. Interregional profiles of group differences in cortical thickness for each of the 6 psychiatric disorders were associated with profiles of gene expression specific to pyramidal (CA1) cells, astrocytes (except for BD), and microglia (exce
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- 2021
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9. Report of an international expanded access program of imatinib in adults with Philadelphia chromosome positive leukemias
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Capdeville, R., Krahnke, T., Hatfield, A., Ford, J.M., Van Hoomissen, I., and Gathmann, I.
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- 2008
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10. The genetic architecture of the human cerebral cortex
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Grasby, K.L., Jahanshad, N., Painter, J.N., Colodro-Conde, L., Bralten, J., Hibar, D.P., Lind, P.A., Pizzagalli, F., Ching, C.R., McMahon, M.A., Shatokhina, N., Zsembik, L.C.P., Thomopoulos, S.I., Zhu, A.H., Strike, L.T., Agartz, I., Alhusaini, S., Almeida, M.A. de, Alnaes, D., Amlien, I.K., Andersson, M., Ard, T., Armstrong, N.J., Ashley-Koch, A., Atkins, J.R., Bernard, M., Brouwer, R.M., Buimer, E.E.L., Bulow, R., Burger, C., Cannon, D.M., Chakravarty, M., Chen, Q., Cheung, J.W., Couvy-Duchesne, B., Dale, A.M., Dalvie, S., Araujo, T.K. de, Zubicaray, G.I. de, Zwarte, S.M.C. de, Braber, A., Doan, N.T., Dohm, K., Ehrlich, S., Engelbrecht, H.R., Erk, S., Fan, C.C., Fedko, I.O., Foley, S.F., Ford, J.M., Fukunaga, M., Garrett, M.E., Ge, T., Giddaluru, S., Goldman, A.L., Green, M.J., Groenewold, N.A., Grotegerd, D., Gurholt, T.P., Gutman, B.A., Hansell, N.K., Harris, Mark F., Harrison, M.B., Haswell, C.C., Hauser, M., Herms, S., Heslenfeld, D.J., Ho, N.F., Hoehn, D., Hoffmann, P., Holleran, L., Hoogman, M., Hottenga, J.J., Ikeda, M., Janowitz, D., Jansen, I.E., Jia, T., Jockwitz, C., Kanai, R., Karama, S., Kasperaviciute, D., Kaufmann, T., Kelly, S., Kikuchi, M., Klein, M., Knapp, M., Knodt, A.R., Kramer, B., Lam, M., Lancaster, T.M., Lee, P.H., Lett, T.A., Lewis, L.B., Lopes-Cendes, I., Luciano, M., Macciardi, F., Marquand, A.F., Mathias, S.R., Melzer, T.R., Milaneschi, Y., Franke, B., Thompson, P.M., Medland, S.E., Grasby, K.L., Jahanshad, N., Painter, J.N., Colodro-Conde, L., Bralten, J., Hibar, D.P., Lind, P.A., Pizzagalli, F., Ching, C.R., McMahon, M.A., Shatokhina, N., Zsembik, L.C.P., Thomopoulos, S.I., Zhu, A.H., Strike, L.T., Agartz, I., Alhusaini, S., Almeida, M.A. de, Alnaes, D., Amlien, I.K., Andersson, M., Ard, T., Armstrong, N.J., Ashley-Koch, A., Atkins, J.R., Bernard, M., Brouwer, R.M., Buimer, E.E.L., Bulow, R., Burger, C., Cannon, D.M., Chakravarty, M., Chen, Q., Cheung, J.W., Couvy-Duchesne, B., Dale, A.M., Dalvie, S., Araujo, T.K. de, Zubicaray, G.I. de, Zwarte, S.M.C. de, Braber, A., Doan, N.T., Dohm, K., Ehrlich, S., Engelbrecht, H.R., Erk, S., Fan, C.C., Fedko, I.O., Foley, S.F., Ford, J.M., Fukunaga, M., Garrett, M.E., Ge, T., Giddaluru, S., Goldman, A.L., Green, M.J., Groenewold, N.A., Grotegerd, D., Gurholt, T.P., Gutman, B.A., Hansell, N.K., Harris, Mark F., Harrison, M.B., Haswell, C.C., Hauser, M., Herms, S., Heslenfeld, D.J., Ho, N.F., Hoehn, D., Hoffmann, P., Holleran, L., Hoogman, M., Hottenga, J.J., Ikeda, M., Janowitz, D., Jansen, I.E., Jia, T., Jockwitz, C., Kanai, R., Karama, S., Kasperaviciute, D., Kaufmann, T., Kelly, S., Kikuchi, M., Klein, M., Knapp, M., Knodt, A.R., Kramer, B., Lam, M., Lancaster, T.M., Lee, P.H., Lett, T.A., Lewis, L.B., Lopes-Cendes, I., Luciano, M., Macciardi, F., Marquand, A.F., Mathias, S.R., Melzer, T.R., Milaneschi, Y., Franke, B., Thompson, P.M., and Medland, S.E.
- Abstract
Contains fulltext : 218611.pdf (Publisher’s version ) (Closed access), The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder.
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- 2020
11. Hereditary diffuse gastric cancer: updated clinical practice guidelines
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Blair, V.R., McLeod, M., Carneiro, F., Coit, D.G., D'Addario, J.L., Dieren, J.M. van, Harris, K.L., Hoogerbrugge, N., Oliveira, C. de, Post, R.S. van der, Arnold, J., Benusiglio, P.R., Bisseling, T.M., Boussioutas, A., Cats, A., Charlton, A., Schreiber, K.E., Davis, J.L., Pietro, M.D., Fitzgerald, R.C., Ford, J.M., Gamet, K., Gullo, I., Hardwick, R.H., Huntsman, D.G., Kaurah, P., Kupfer, S.S., Latchford, A., Mansfield, P.F., Nakajima, T., Parry, S., Rossaak, J., Sugimura, H., Svrcek, M., Tischkowitz, M., Ushijima, T., Yamada, H., Yang, H.Keri, Claydon, A., Figueiredo, J., Paringatai, K., Seruca, R., Bougen-Zhukov, N., Brew, T., Busija, S., Carneiro, P., DeGregorio, L., Fisher, H., Gardner, E., Godwin, T.D., Holm, K.N., Humar, B., Lintott, C.J., Monroe, E.C., Muller, M.D., Norero, E., Nouri, Y., Paredes, J., Sanches, J.M., Schulpen, E., Ribeiro, A.S., Sporle, A., Whitworth, J., Zhang, L., Reeve, A.E., Guilford, P., Blair, V.R., McLeod, M., Carneiro, F., Coit, D.G., D'Addario, J.L., Dieren, J.M. van, Harris, K.L., Hoogerbrugge, N., Oliveira, C. de, Post, R.S. van der, Arnold, J., Benusiglio, P.R., Bisseling, T.M., Boussioutas, A., Cats, A., Charlton, A., Schreiber, K.E., Davis, J.L., Pietro, M.D., Fitzgerald, R.C., Ford, J.M., Gamet, K., Gullo, I., Hardwick, R.H., Huntsman, D.G., Kaurah, P., Kupfer, S.S., Latchford, A., Mansfield, P.F., Nakajima, T., Parry, S., Rossaak, J., Sugimura, H., Svrcek, M., Tischkowitz, M., Ushijima, T., Yamada, H., Yang, H.Keri, Claydon, A., Figueiredo, J., Paringatai, K., Seruca, R., Bougen-Zhukov, N., Brew, T., Busija, S., Carneiro, P., DeGregorio, L., Fisher, H., Gardner, E., Godwin, T.D., Holm, K.N., Humar, B., Lintott, C.J., Monroe, E.C., Muller, M.D., Norero, E., Nouri, Y., Paredes, J., Sanches, J.M., Schulpen, E., Ribeiro, A.S., Sporle, A., Whitworth, J., Zhang, L., Reeve, A.E., and Guilford, P.
- Abstract
Contains fulltext : 225261.pdf (Publisher’s version ) (Closed access), Hereditary diffuse gastric cancer (HDGC) is an autosomal dominant cancer syndrome that is characterised by a high prevalence of diffuse gastric cancer and lobular breast cancer. It is largely caused by inactivating germline mutations in the tumour suppressor gene CDH1, although pathogenic variants in CTNNA1 occur in a minority of families with HDGC. In this Policy Review, we present updated clinical practice guidelines for HDGC from the International Gastric Cancer Linkage Consortium (IGCLC), which recognise the emerging evidence of variability in gastric cancer risk between families with HDGC, the growing capability of endoscopic and histological surveillance in HDGC, and increased experience of managing long-term sequelae of total gastrectomy in young patients. To redress the balance between the accessibility, cost, and acceptance of genetic testing and the increased identification of pathogenic variant carriers, the HDGC genetic testing criteria have been relaxed, mainly through less restrictive age limits. Prophylactic total gastrectomy remains the recommended option for gastric cancer risk management in pathogenic CDH1 variant carriers. However, there is increasing confidence from the IGCLC that endoscopic surveillance in expert centres can be safely offered to patients who wish to postpone surgery, or to those whose risk of developing gastric cancer is not well defined.
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- 2020
12. DNA Repair Defects and Human Disease
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Hanawalt, P.C., primary and Ford, J.M., additional
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- 2013
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13. Converging evidence for gamma synchrony deficits in schizophrenia
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Roach, B.J., primary, Ford, J.M., additional, Hoffman, R.E., additional, and Mathalon, D.H., additional
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- 2013
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14. Multi-Spatial Scale Dynamic Interactions between Functional Sources Reveal Sex-Specific Changes in Schizophrenia
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Iraji, A., primary, Faghiri, A., additional, Fu, Z., additional, Rachakonda, S., additional, Kochunov, P., additional, Belger, A., additional, Ford, J.M., additional, McEwen, S., additional, Mathalon, D.H., additional, Mueller, B.A., additional, Pearlson, G.D., additional, Potkin, S.G., additional, Preda, A., additional, Turner, J.A., additional, van Erp, T.G.M., additional, and Calhoun, V.D., additional
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- 2021
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15. fMRI Activity Correlated With Auditory Hallucinations During Performance of a Working Memory Task: Data From the FBIRN Consortium Study
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Wible, C.G., Lee, K., Molina, I., Hashimoto, R., Preus, A.P., Roach, B.J., Ford, J.M., Mathalon, D.H., McCarthey, G., Turner, J.A., Potkin, S.G., OʼLeary, D., Belger, A., Diaz, M., Voyvodic, J., Brown, G.G., Notestine, R., Greve, D., and Lauriello, J.
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- 2009
16. Auditory Oddball Deficits in Schizophrenia: An Independent Component Analysis of the fMRI Multisite Function BIRN Study
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Kim, Dae Il, Mathalon, D.H., Ford, J.M., Mannell, M., Turner, J.A., Brown, G.G., Belger, A., Gollub, R., Lauriello, J., Wible, C., OʼLeary, D., Lim, K., Toga, A., Potkin, S.G., Birn, F., and Calhoun, V.D.
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- 2009
17. Computational approaches to parameter estimation and model selection in immunology
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Baker, C.T.H., Bocharov, G.A., Ford, J.M., Lumb, P.M., Norton, S.J., Paul, C.A.H., Junt, T., Krebs, P., and Ludewig, B.
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- 2005
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18. Long-Term Follow-Up Using Linac Radiosurgery and Stereotactic Radiotherapy as a Minimally Invasive Treatment for Intracranial Meningiomas
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Torres, R.C., primary, De Salles, A.A.F., additional, Frighetto, L., additional, Gravori, T., additional, Pedroso, A.G., additional, Goss, B., additional, Medin, P., additional, Solberg, T.D., additional, Ford, J.M., additional, and Selch, M., additional
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- 2004
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19. Modelling interface diffusion creep in two-phase materials
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Ford, J.M. and Wheeler, J.
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- 2004
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20. Cumulative Dose to Targets, Critical Structures, and the Whole Brain from the Treatment of Multiple Intracranial Metastases
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Boone, R.A., primary, Solberg, T.D., additional, Selch, M.T., additional, De Salles, A.A.F., additional, and Ford, J.M., additional
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- 1999
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21. Factors Related to Radiation Injury after Radiosurgery of Arteriovenous Malformations of the Brain
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De Salles, A.A.F., primary, Sun, B., additional, Solberg, T.D., additional, Cabatan-Awang, C., additional, Ford, J.M., additional, and Selch, M.T., additional
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- 1999
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22. Computer simulation of grain-boundary diffusion creep
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Ford, J.M., Wheeler, J., and Movchan, A.B.
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- 2002
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23. Widespread white matter microstructural differences in schizophrenia across 4322 individuals: results from the ENIGMA Schizophrenia DTI Working Group
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Kelly, S., Jahanshad, N., Zalesky, A., Kochunov, P., Agartz, I., Alloza, C., Andreassen, O.A., Arango, C., Banaj, N., Bouix, S., Bousman, C.A., Brouwer, R.M., Bruggemann, J., Bustillo, J., Cahn, W., Calhoun, V., Cannon, D., Carr, V., Catts, S., Chen, J., Chen, J.X., Chen, X, Chiapponi, C., Cho, K.K., Ciullo, V., Corvin, A.S., Crespo-Facorro, B., Cropley, V., Rossi, P., Diaz-Caneja, C.M., Dickie, E.W., Ehrlich, S., Fan, F.M., Faskowitz, J., Fatouros-Bergman, H., Flyckt, L., Ford, J.M., Fouche, J.P., Fukunaga, M., Gill, M., Glahn, D.C., Gollub, R., Goudzwaard, E.D., Guo, H, Gur, R.E., Gur, R.C., Gurholt, T.P., Hashimoto, R., Hatton, S.N., Henskens, F.A., Hibar, D.P., Hickie, I.B., Hong, L.E., Horacek, J., Howells, F.M., Pol, H.E., Hyde, C.L., Isaev, D., Jablensky, A., Jansen, P.R., Janssen, J, Jonsson, E.G., Jung, L.A., Kahn, R.S., Kikinis, Z., Liu, K, Klauser, P., Knochel, C., Kubicki, M., Lagopoulos, J., Langen, C., Lawrie, S., Lenroot, R.K., Lim, K.O., Lopez-Jaramillo, C., Lyall, A., Magnotta, V., Mandl, R.C.W., Mathalon, D.H., McCarley, R.W., McCarthy-Jones, S., McDonald, C., McEwen, S., McIntosh, A., Melicher, T., Mesholam-Gately, R.I., Michie, P.T., Mowry, B., Mueller, B.A., Newell, D.T., O'Donnell, P., Oertel-Knochel, V., Oestreich, L., Paciga, S.A., Pantelis, C., Pasternak, O., Pearlson, G., Pellicano, G.R., Pereira, A., Zapata, J., Sprooten, E., Thompson, P.M., Donohoe, G., Kelly, S., Jahanshad, N., Zalesky, A., Kochunov, P., Agartz, I., Alloza, C., Andreassen, O.A., Arango, C., Banaj, N., Bouix, S., Bousman, C.A., Brouwer, R.M., Bruggemann, J., Bustillo, J., Cahn, W., Calhoun, V., Cannon, D., Carr, V., Catts, S., Chen, J., Chen, J.X., Chen, X, Chiapponi, C., Cho, K.K., Ciullo, V., Corvin, A.S., Crespo-Facorro, B., Cropley, V., Rossi, P., Diaz-Caneja, C.M., Dickie, E.W., Ehrlich, S., Fan, F.M., Faskowitz, J., Fatouros-Bergman, H., Flyckt, L., Ford, J.M., Fouche, J.P., Fukunaga, M., Gill, M., Glahn, D.C., Gollub, R., Goudzwaard, E.D., Guo, H, Gur, R.E., Gur, R.C., Gurholt, T.P., Hashimoto, R., Hatton, S.N., Henskens, F.A., Hibar, D.P., Hickie, I.B., Hong, L.E., Horacek, J., Howells, F.M., Pol, H.E., Hyde, C.L., Isaev, D., Jablensky, A., Jansen, P.R., Janssen, J, Jonsson, E.G., Jung, L.A., Kahn, R.S., Kikinis, Z., Liu, K, Klauser, P., Knochel, C., Kubicki, M., Lagopoulos, J., Langen, C., Lawrie, S., Lenroot, R.K., Lim, K.O., Lopez-Jaramillo, C., Lyall, A., Magnotta, V., Mandl, R.C.W., Mathalon, D.H., McCarley, R.W., McCarthy-Jones, S., McDonald, C., McEwen, S., McIntosh, A., Melicher, T., Mesholam-Gately, R.I., Michie, P.T., Mowry, B., Mueller, B.A., Newell, D.T., O'Donnell, P., Oertel-Knochel, V., Oestreich, L., Paciga, S.A., Pantelis, C., Pasternak, O., Pearlson, G., Pellicano, G.R., Pereira, A., Zapata, J., Sprooten, E., Thompson, P.M., and Donohoe, G.
- Abstract
Contains fulltext : 193179.pdf (Publisher’s version ) (Open Access), The regional distribution of white matter (WM) abnormalities in schizophrenia remains poorly understood, and reported disease effects on the brain vary widely between studies. In an effort to identify commonalities across studies, we perform what we believe is the first ever large-scale coordinated study of WM microstructural differences in schizophrenia. Our analysis consisted of 2359 healthy controls and 1963 schizophrenia patients from 29 independent international studies; we harmonized the processing and statistical analyses of diffusion tensor imaging (DTI) data across sites and meta-analyzed effects across studies. Significant reductions in fractional anisotropy (FA) in schizophrenia patients were widespread, and detected in 20 of 25 regions of interest within a WM skeleton representing all major WM fasciculi. Effect sizes varied by region, peaking at (d=0.42) for the entire WM skeleton, driven more by peripheral areas as opposed to the core WM where regions of interest were defined. The anterior corona radiata (d=0.40) and corpus callosum (d=0.39), specifically its body (d=0.39) and genu (d=0.37), showed greatest effects. Significant decreases, to lesser degrees, were observed in almost all regions analyzed. Larger effect sizes were observed for FA than diffusivity measures; significantly higher mean and radial diffusivity was observed for schizophrenia patients compared with controls. No significant effects of age at onset of schizophrenia or medication dosage were detected. As the largest coordinated analysis of WM differences in a psychiatric disorder to date, the present study provides a robust profile of widespread WM abnormalities in schizophrenia patients worldwide. Interactive three-dimensional visualization of the results is available at www.enigma-viewer.org.
- Published
- 2018
24. Widespread white matter microstructural differences in schizophrenia across 4322 individuals: Results from the ENIGMA Schizophrenia DTI Working Group.
- Author
-
Faskowitz J., Jablensky A., Jansen P.R., Janssen J., Jonsson E.G., Jung L.A., Kahn R.S., Kikinis Z., Liu K., Klauser P., Knochel C., Kubicki M., Lagopoulos J., Langen C., Lawrie S., Lenroot R.K., Lim K.O., Lopez-Jaramillo C., Lyall A., Magnotta V., Mandl R.C.W., McIntosh A., Melicher T., Mesholam-Gately R.I., Michie P.T., Mowry B., Mueller B.A., Newell D.T., O'Donnell P., Oertel-Knochel V., Oestreich L., Paciga S.A., Pantelis C., Pasternak O., Pearlson G., Pellicano G.R., Pereira A., Pineda Zapata J., Piras F., Potkin S.G., Preda A., Rasser P.E., Roalf D.R., Roiz R., Roos A., Rotenberg D., Satterthwaite T.D., Savadjiev P., Schall U., Scott R.J., Seal M.L., Seidman L.J., Shannon Weickert C., Whelan C.D., Shenton M.E., Kwon J.S., Spalletta G., Spaniel F., Sprooten E., Stablein M., Stein D.J., Tan Y., Tan S., Tang S., Temmingh H.S., Westlye L.T., Tonnesen S., Tordesillas-Gutierrez D., Doan N.T., Vaidya J., Van Haren N.E.M., Vargas C.D., Vecchio D., Velakoulis D., Voineskos A., Voyvodic J.Q., Wang Z., Wan P., Wei D., Weickert T.W., Whalley H., White T., Whitford T.J., Wojcik J.D., Xiang H., Xie Z., Yamamori H., Yang F., Yao N., Zhang G., Zhao J., Van Erp T.G.M., Turner J., Thompson P.M., Donohoe G., Sundram S., Kelly S., Jahanshad N., Zalesky A., Kochunov P., Agartz I., Alloza C., Andreassen O.A., Arango C., Banaj N., Bouix S., Bousman C.A., Brouwer R.M., Bruggemann J., Bustillo J., Cahn W., Calhoun V., Cannon D., Carr V., Catts S., Chen J., Chen J.-X., Chen X., Chiapponi C., Cho K.K., Ciullo V., Corvin A.S., Crespo-Facorro B., Cropley V., De Rossi P., Diaz-Caneja C.M., Dickie E.W., Ehrlich S., Fan F.-M., Fatouros-Bergman H., Flyckt L., Ford J.M., Fouche J.-P., Fukunaga M., Gill M., Glahn D.C., Gollub R., Goudzwaard E.D., Guo H., Gur R.E., Gur R.C., Gurholt T.P., Hashimoto R., Hatton S.N., Henskens F.A., Hibar D.P., Hickie I.B., Hong L.E., Horacek J., Howells F.M., Hulshoff Pol H.E., Hyde C.L., Isaev D., Mathalon D.H., McCarley R.W., McCarthy-Jones S., McDonald C., McEwen S., Faskowitz J., Jablensky A., Jansen P.R., Janssen J., Jonsson E.G., Jung L.A., Kahn R.S., Kikinis Z., Liu K., Klauser P., Knochel C., Kubicki M., Lagopoulos J., Langen C., Lawrie S., Lenroot R.K., Lim K.O., Lopez-Jaramillo C., Lyall A., Magnotta V., Mandl R.C.W., McIntosh A., Melicher T., Mesholam-Gately R.I., Michie P.T., Mowry B., Mueller B.A., Newell D.T., O'Donnell P., Oertel-Knochel V., Oestreich L., Paciga S.A., Pantelis C., Pasternak O., Pearlson G., Pellicano G.R., Pereira A., Pineda Zapata J., Piras F., Potkin S.G., Preda A., Rasser P.E., Roalf D.R., Roiz R., Roos A., Rotenberg D., Satterthwaite T.D., Savadjiev P., Schall U., Scott R.J., Seal M.L., Seidman L.J., Shannon Weickert C., Whelan C.D., Shenton M.E., Kwon J.S., Spalletta G., Spaniel F., Sprooten E., Stablein M., Stein D.J., Tan Y., Tan S., Tang S., Temmingh H.S., Westlye L.T., Tonnesen S., Tordesillas-Gutierrez D., Doan N.T., Vaidya J., Van Haren N.E.M., Vargas C.D., Vecchio D., Velakoulis D., Voineskos A., Voyvodic J.Q., Wang Z., Wan P., Wei D., Weickert T.W., Whalley H., White T., Whitford T.J., Wojcik J.D., Xiang H., Xie Z., Yamamori H., Yang F., Yao N., Zhang G., Zhao J., Van Erp T.G.M., Turner J., Thompson P.M., Donohoe G., Sundram S., Kelly S., Jahanshad N., Zalesky A., Kochunov P., Agartz I., Alloza C., Andreassen O.A., Arango C., Banaj N., Bouix S., Bousman C.A., Brouwer R.M., Bruggemann J., Bustillo J., Cahn W., Calhoun V., Cannon D., Carr V., Catts S., Chen J., Chen J.-X., Chen X., Chiapponi C., Cho K.K., Ciullo V., Corvin A.S., Crespo-Facorro B., Cropley V., De Rossi P., Diaz-Caneja C.M., Dickie E.W., Ehrlich S., Fan F.-M., Fatouros-Bergman H., Flyckt L., Ford J.M., Fouche J.-P., Fukunaga M., Gill M., Glahn D.C., Gollub R., Goudzwaard E.D., Guo H., Gur R.E., Gur R.C., Gurholt T.P., Hashimoto R., Hatton S.N., Henskens F.A., Hibar D.P., Hickie I.B., Hong L.E., Horacek J., Howells F.M., Hulshoff Pol H.E., Hyde C.L., Isaev D., Mathalon D.H., McCarley R.W., McCarthy-Jones S., McDonald C., and McEwen S.
- Abstract
The regional distribution of white matter (WM) abnormalities in schizophrenia remains poorly understood, and reported disease effects on the brain vary widely between studies. In an effort to identify commonalities across studies, we perform what we believe is the first ever large-scale coordinated study of WM microstructural differences in schizophrenia. Our analysis consisted of 2359 healthy controls and 1963 schizophrenia patients from 29 independent international studies; we harmonized the processing and statistical analyses of diffusion tensor imaging (DTI) data across sites and meta-analyzed effects across studies. Significant reductions in fractional anisotropy (FA) in schizophrenia patients were widespread, and detected in 20 of 25 regions of interest within a WM skeleton representing all major WM fasciculi. Effect sizes varied by region, peaking at (d=0.42) for the entire WM skeleton, driven more by peripheral areas as opposed to the core WM where regions of interest were defined. The anterior corona radiata (d=0.40) and corpus callosum (d=0.39), specifically its body (d=0.39) and genu (d=0.37), showed greatest effects. Significant decreases, to lesser degrees, were observed in almost all regions analyzed. Larger effect sizes were observed for FA than diffusivity measures; significantly higher mean and radial diffusivity was observed for schizophrenia patients compared with controls. No significant effects of age at onset of schizophrenia or medication dosage were detected. As the largest coordinated analysis of WM differences in a psychiatric disorder to date, the present study provides a robust profile of widespread WM abnormalities in schizophrenia patients worldwide. Interactive three-dimensional visualization of the results is available at www.enigma-viewer.org.Copyright © The Author(s) 2018.
- Published
- 2018
25. Widespread white matter microstructural differences in schizophrenia across 4322 individuals: Results from the ENIGMA Schizophrenia DTI Working Group
- Author
-
Kelly, S. (S.), Jahanshad, N. (Neda), Zalesky, A. (A.), Kochunov, P. (P.), Agartz, I. (Ingrid), Alloza, C. (C.), Andreassen, O.A. (O. A.), Arango, C. (C.), Banaj, N. (N.), Bouix, S. (S.), Bousman, C.A. (C. A.), Brouwer, R.M. (Rachel), Bruggemann, J. (J.), Bustillo, J., Cahn, W. (Wiepke), Calhoun, V.D. (Vince), Cannon, D. (D.), Carr, V.J. (Vaughan), Catts, S.V. (Stanley), Chen, J. (J.), Chen, J.-X. (J. X.), Chen, X. (X.), Chiapponi, C. (C.), Cho, K.K. (Kl K), Ciullo, V. (V.), Corvin, A. (Aiden), Crespo-Facorro, B. (Benedicto), Cropley, V. (V.), De Rossi, P. (P.), Diaz-Caneja, C.M. (C. M.), Dickie, E.W. (E. W.), Ehrlich, S.M. (Stefan), Fan, F.-M. (F. M.), Faskowitz, J. (J.), Fatouros-Bergman, H. (H.), Flyckt, L. (L.), Ford, J.M. (J. M.), Fouche, J.-P. (J. P.), Fukunaga, M. (Masaki), Gill, M. (M.), Glahn, D.C. (David), Gollub, R.L. (Randy), Goudzwaard, E.D. (E. D.), Guo, H. (H.), Gur, R.E. (Raquel), Gur, R.C. (R. C.), Gurholt, T.P. (T. P.), Hashimoto, R. (Ryota), Hatton, W., Henskens, F.A. (Frans), Hibar, D.P. (D. P.), Hickie, I.B. (Ian), Hong, L.E. (L. E.), Horacek, J. (J.), Howells, F.M. (F. M.), Hulshoff Pol, H.E. (Hilleke), Hyde, C.L. (C. L.), Isaev, D. (D.), Jablensky, A. (A.), Jansen, P.R. (P. R.), Janssen, J. (J.), Jönsson, E.G. (Erik), Jung, L.A. (L. A.), Kahn, R.S. (R. S.), Kikinis, Z. (Z.), Liu, K. (K.), Klauser, P. (P.), Knöchel, C. (C.), Kubicki, M. (M.), Lagopoulos, J. (Jim), Langen, C.D. (Carolyn), Lawrie, S. (Stephen), Lenroot, R.K. (Rhoshel), Lim, K.O. (Kelvin), Lopez-Jaramillo, C. (C.), Lyall, A. (A.), Magnotta, V., Mandl, R. (René), Mathalon, D.H. (D. H.), McCarley, R.W. (Robert), McCarthy-Jones, S. (S.), McDonald, C. (Colm), McEwen, S. (S.), McIntosh, A.M. (Andrew), Melicher, T. (T.), Mesholam-Gately, R.I. (Raquelle), Michie, P.T. (Patricia), Mowry, B.J. (Bryan J), Mueller, B.A. (Bryon ), Newell, D.T. (D. T.), O'Donnell, P. (P.), Oertel-Knöchel, V. (V.), Oestreich, L. (L.), Paciga, S.A. (S. A.), Pantelis, C. (Christos), Pasternak, O. (O.), Pearlson, G. (G.), Pellicano, G.R. (G. R.), Pereira, A. (A.), Pineda Zapata, J. (J.), Piras, F. (F.), Potkin, S.G. (Steven), Preda, A. (A.), Rasser, P.E. (P. E.), Roalf, D.R. (D. R.), Roiz, R. (R.), Roos, A. (A.), Rotenberg, D. (D.), Satterthwaite, T.D. (Theodore), Savadjiev, P. (P.), Schall, J.D. (Jeffrey), Scott, R.J. (R. J.), Seal, M.L. (M. L.), Seidman, L.J. (Larry), Shannon Weickert, C. (C.), Whelan, C.D. (Christopher), Shenton, M.E. (M. E.), Kwon, J.S. (J. S.), Spalletta, G. (Gianfranco), Spaniel, F. (F.), Sprooten, R. (Roy), Stäblein, M. (M.), Stein, D.J. (Dan), Sundram, S. (S.), Tan, Y. (Y.), Tan, S. (S.), Tang, S. (S.), Temmingh, H.S. (H. S.), Westlye, L.T. (Lars), Tønnesen, S. (S.), Tordesillas-Gutierrez, D. (Diana), Doan, N.T. (N. T.), Vaidya, J. (J.), Van Haren, N.E.M. (N. E.M.), Vargas, C.D. (C. D.), Vecchio, D. (D.), Velakoulis, D. (D.), Voineskos, A. (A.), Voyvodic, J.Q. (J. Q.), Wang, Z. (Z.), Wan, P. (P.), Wei, D. (D.), Weickert, T.W. (T. W.), Whalley, H. (H.), White, T.J.H. (Tonya), Whitford, T.J. (T. J.), Wojcik, J.D. (J. D.), Xiang, H. (H.), Xie, Z. (Z.), Yamamori, H. (H.), Yang, F. (F.), Yao, N. (N.), Zhang, G. (G.), Zhao, J. (J.), Erp, T.G.M. (Theo G.) van, Turner, J. (Jessica), Thompson, P.M. (P. M.), Donohoe, D.J. (Dennis), Kelly, S. (S.), Jahanshad, N. (Neda), Zalesky, A. (A.), Kochunov, P. (P.), Agartz, I. (Ingrid), Alloza, C. (C.), Andreassen, O.A. (O. A.), Arango, C. (C.), Banaj, N. (N.), Bouix, S. (S.), Bousman, C.A. (C. A.), Brouwer, R.M. (Rachel), Bruggemann, J. (J.), Bustillo, J., Cahn, W. (Wiepke), Calhoun, V.D. (Vince), Cannon, D. (D.), Carr, V.J. (Vaughan), Catts, S.V. (Stanley), Chen, J. (J.), Chen, J.-X. (J. X.), Chen, X. (X.), Chiapponi, C. (C.), Cho, K.K. (Kl K), Ciullo, V. (V.), Corvin, A. (Aiden), Crespo-Facorro, B. (Benedicto), Cropley, V. (V.), De Rossi, P. (P.), Diaz-Caneja, C.M. (C. M.), Dickie, E.W. (E. W.), Ehrlich, S.M. (Stefan), Fan, F.-M. (F. M.), Faskowitz, J. (J.), Fatouros-Bergman, H. (H.), Flyckt, L. (L.), Ford, J.M. (J. M.), Fouche, J.-P. (J. P.), Fukunaga, M. (Masaki), Gill, M. (M.), Glahn, D.C. (David), Gollub, R.L. (Randy), Goudzwaard, E.D. (E. D.), Guo, H. (H.), Gur, R.E. (Raquel), Gur, R.C. (R. C.), Gurholt, T.P. (T. P.), Hashimoto, R. (Ryota), Hatton, W., Henskens, F.A. (Frans), Hibar, D.P. (D. P.), Hickie, I.B. (Ian), Hong, L.E. (L. E.), Horacek, J. (J.), Howells, F.M. (F. M.), Hulshoff Pol, H.E. (Hilleke), Hyde, C.L. (C. L.), Isaev, D. (D.), Jablensky, A. (A.), Jansen, P.R. (P. R.), Janssen, J. (J.), Jönsson, E.G. (Erik), Jung, L.A. (L. A.), Kahn, R.S. (R. S.), Kikinis, Z. (Z.), Liu, K. (K.), Klauser, P. (P.), Knöchel, C. (C.), Kubicki, M. (M.), Lagopoulos, J. (Jim), Langen, C.D. (Carolyn), Lawrie, S. (Stephen), Lenroot, R.K. (Rhoshel), Lim, K.O. (Kelvin), Lopez-Jaramillo, C. (C.), Lyall, A. (A.), Magnotta, V., Mandl, R. (René), Mathalon, D.H. (D. H.), McCarley, R.W. (Robert), McCarthy-Jones, S. (S.), McDonald, C. (Colm), McEwen, S. (S.), McIntosh, A.M. (Andrew), Melicher, T. (T.), Mesholam-Gately, R.I. (Raquelle), Michie, P.T. (Patricia), Mowry, B.J. (Bryan J), Mueller, B.A. (Bryon ), Newell, D.T. (D. T.), O'Donnell, P. (P.), Oertel-Knöchel, V. (V.), Oestreich, L. (L.), Paciga, S.A. (S. A.), Pantelis, C. (Christos), Pasternak, O. (O.), Pearlson, G. (G.), Pellicano, G.R. (G. R.), Pereira, A. (A.), Pineda Zapata, J. (J.), Piras, F. (F.), Potkin, S.G. (Steven), Preda, A. (A.), Rasser, P.E. (P. E.), Roalf, D.R. (D. R.), Roiz, R. (R.), Roos, A. (A.), Rotenberg, D. (D.), Satterthwaite, T.D. (Theodore), Savadjiev, P. (P.), Schall, J.D. (Jeffrey), Scott, R.J. (R. J.), Seal, M.L. (M. L.), Seidman, L.J. (Larry), Shannon Weickert, C. (C.), Whelan, C.D. (Christopher), Shenton, M.E. (M. E.), Kwon, J.S. (J. S.), Spalletta, G. (Gianfranco), Spaniel, F. (F.), Sprooten, R. (Roy), Stäblein, M. (M.), Stein, D.J. (Dan), Sundram, S. (S.), Tan, Y. (Y.), Tan, S. (S.), Tang, S. (S.), Temmingh, H.S. (H. S.), Westlye, L.T. (Lars), Tønnesen, S. (S.), Tordesillas-Gutierrez, D. (Diana), Doan, N.T. (N. T.), Vaidya, J. (J.), Van Haren, N.E.M. (N. E.M.), Vargas, C.D. (C. D.), Vecchio, D. (D.), Velakoulis, D. (D.), Voineskos, A. (A.), Voyvodic, J.Q. (J. Q.), Wang, Z. (Z.), Wan, P. (P.), Wei, D. (D.), Weickert, T.W. (T. W.), Whalley, H. (H.), White, T.J.H. (Tonya), Whitford, T.J. (T. J.), Wojcik, J.D. (J. D.), Xiang, H. (H.), Xie, Z. (Z.), Yamamori, H. (H.), Yang, F. (F.), Yao, N. (N.), Zhang, G. (G.), Zhao, J. (J.), Erp, T.G.M. (Theo G.) van, Turner, J. (Jessica), Thompson, P.M. (P. M.), and Donohoe, D.J. (Dennis)
- Abstract
The regional distribution of white matter (WM) abnormalities in schizophrenia remains poorly understood, and reported disease effects on the brain vary widely between studies. In an effort to identify commonalities across studies, we perform what we believe is the first ever large-scale coordinated study of WM microstructural differences in schizophrenia. Our analysis consisted of 2359 healthy controls and 1963 schizophrenia patients from 29 independent international studies; we harmonized the processing and statistical analyses of diffusion tensor imaging (DTI) data across sites and meta-analyzed effects across studies. Significant reductions in fractional anisotropy (FA) in schizophrenia patients were widespread, and detected in 20 of 25 regions of interest within a WM skeleton representing all major WM fasciculi. Effect sizes varied by region, peaking at (d=0.42) for the entire WM skeleton, driven more by peripheral areas as opposed to the core WM where regions of interest were defined. The anterior corona radiata (d=0.40) and corpus callosum (d=0.39), specifically its body (d=0.39) and genu (d=0.37), showed greatest effects. Significant decreases, to lesser degrees, were observed in almost all regions analyzed. Larger effect sizes were observed for FA than diffusivity measures; significantly higher mean and radial diffusivity was observed for schizophrenia patients compared with controls. No significant effects of age at onset of schizophrenia or medication dosage were detected. As the largest coordinated analysis of WM differences in a psychiatric disorder to date, the present study provides a robust profile of widespread WM abnormalities in schizophrenia patients worldwide. Interactive three-dimensional visualization of the results is available at www.enigma-viewer.org.
- Published
- 2018
- Full Text
- View/download PDF
26. Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium
- Author
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Erp, T.G.M. (Theo G.) van, Walton, E. (Esther), Hibar, D.P. (Derrek P.), Schmaal, L. (Lianne), Jiang, W. (Wenhao), Glahn, D.C. (David), Pearlson, G. (Godfrey), Yao, N. (Nailin), Fukunaga, M. (Masaki), Hashimoto, R. (Ryota), Okada, N. (Naohiro), Yamamori, H. (Hidenaga), Bustillo, J., Clark, V.P., Agartz, I. (Ingrid), Mueller, B.A. (Bryon ), Cahn, W. (Wiepke), de Zwarte, S.M.C. (Sonja M.C.), Hulshoff Pol, H.E. (Hilleke), Kahn, R. (René), Ophoff, R.A. (Roel), van Haren, N.E.M. (Neeltje E.M.), Andreassen, O.A. (Ole), Dale, A.M. (Anders), Doan, N.T. (Nhat Trung), Gurholt, T.P. (Tiril P.), Hartberg, C.B. (Cecilie B.), Haukvik, U.K. (Unn), Jørgensen, K.N. (Kjetil N.), Lagerberg, T.V. (Trine V.), Melle, I. (Ingrid), Westlye, L.T. (Lars), Gruber, O. (Oliver), Kraemer, B. (Bernd), Richter, A. (Anja), Zilles, D. (David), Calhoun, V.D. (Vince), Crespo-Facorro, B. (Benedicto), Roiz-Santiañez, R. (Roberto), Tordesillas-Gutierrez, D. (Diana), Loughland, C.M. (Carmel), Carr, V.J. (Vaughan J.), Catts, S.V. (Stanley), Cropley, V.L. (Vanessa L.), Fullerton, J.M. (Janice M.), Green, M.J. (Melissa J.), Henskens, F.A. (Frans), Jablensky, A. (Assen), Lenroot, R.K. (Rhoshel), Mowry, B.J. (Bryan J), Michie, P.T. (Patricia), Pantelis, C. (Christos), Quidé, Y. (Yann), Schall, J.D. (Jeffrey), Scott, R.J. (Rodney J.), Cairns, M.J. (Murray J.), Seal, M. (Marc), Tooney, P.A. (Paul A.), Rasser, P.E. (Paul E.), Cooper, G. (Gavin), Shannon Weickert, C. (Cynthia), Weickert, T.W. (Thomas W.), Morris, D.W. (Derek W), Hong, E. (Elliot), Kochunov, P. (Peter), Beard, L.M. (Lauren M.), Gur, R.E. (Raquel), Gur, R.C. (Ruben C.), Satterthwaite, T.D. (Theodore), Wolf, D.H. (Daniel H.), Belger, A. (Aysenil), Brown, G.G. (Gregory G.), Ford, J.M. (Judith M.), Macciardi, F. (Fabio), Mathalon, D.H. (Daniel H.), O'Leary, D.S. (Daniel S.), Potkin, S.G. (Steven), Preda, A. (Adrian), Voyvodic, J. (James), Lim, K.O. (Kelvin), McEwen, S. (Sarah), Yang, F. (Fude), Tan, Y. (Yunlong), Tan, S. (Shuping), Wang, Z. (Zhiren), Fan, F. (Fengmei), Chen, J. (Jingxu), Xiang, H. (Hong), Tang, S. (Shiyou), Guo, H. (Hua), Wan, P. (Ping), Wei, D. (Dong), Bockholt, H.J., Ehrlich, S.M. (Stefan), Wolthusen, R.P.F. (Rick P.F.), King, M.D. (Margaret D.), Shoemaker, J.M. (Jody M.), Sponheim, S.R. (Scott), Haan, L. (Lieuwe) de, Koenders, L. (Laura), Machielsen, M.W.J. (Marise), Amelsvoort, T.A.M.J. (Therese) van, Veltman, D.J. (Dick), Assogna, F. (Francesca), Banaj, N. (Nerisa), de Rossi, P. (Pietro), Iorio, M. (Mariangela), Piras, F. (Fabrizio), Spalletta, G. (Gianfranco), McKenna, P.J. (Peter J.), Pomarol-Clotet, E. (Edith), Salvador, R. (Raymond), Corvin, A. (Aiden), Donohoe, D.J. (Dennis), Kelly, S. (Sinead), Whelan, C.D. (Christopher), Dickie, E.W. (Erin W.), Rotenberg, D. (David), Voineskos, A.N. (Aristotle N.), Ciufolini, S. (Simone), Radua, J. (Joaquim), Dazzan, P. (Paola), Murray, R. (Robin), Reis Marques, T. (Tiago), Simmons, A. (Andrew), Borgwardt, S. (Stefan), Egloff, L. (Laura), Harrisberger, F. (Fabienne), Riecher-Rössler, A. (Anita), Smieskova, R. (Renata), Alpert, K. (Kathryn), Wang, L. (Lei), Jönsson, E.G. (Erik), Koops, S. (Sanne), Sommer, I.E.C. (Iris E.C.), Bertolino, A. (Alessandro), Bonvino, A. (Aurora), Di Giorgio, A. (Annabella), Neilson, E. (Emma), Mayer, A.R. (Andrew R.), Stephen, J.M. (Julia M.), Kwon, J.S. (Jun Soo), Yun, J.-Y. (Je-Yeon), Cannon, D.M. (Dara), McDonald, C. (Colm), Lebedeva, I. (Irina), Tomyshev, A.S. (Alexander S.), Akhadov, T. (Tolibjohn), Kaleda, V. (Vasily), Fatouros-Bergman, H. (Helena), Flyckt, L. (Lena), Farde, L. (Lars), Engberg, G. (Göran), Erhardt, S. (Sophie), Cervenka, S. (Simon), Schwieler, L. (Lilly), Piehl, F. (Fredrik), Collste, K. (Karin), Victorsson, P. (Pauliina), Malmqvist, A. (Anna), Hedberg, M. (Mikael), Orhan, F. (Funda), Busatto, G.F. (Geraldo F.), Rosa, P.G.P. (Pedro G.P.), Serpa, M.H. (Mauricio H.), Zanetti, M.V. (Marcus V.), Hoschl, C. (Cyril), Skoch, A. (Antonin), Spaniel, F. (Filip), Tomecek, D. (David), Hagenaars, S. (Saskia), McIntosh, A.M. (Andrew), Whalley, H.C. (Heather C.), Lawrie, S. (Stephen), Knöchel, C. (Christian), Oertel-Knöchel, V. (Viola), Stäblein, M. (Michael), Howells, F.M. (Fleur M.), Stein, D.J. (Dan), Temmingh, H.S. (Henk S.), Uhlmann, A. (Anne), Lopez-Jaramillo, C. (Carlos), Dima, D. (Danai), McMahon, A. (Agnes), Faskowitz, J.I. (Joshua I.), Gutman, B.A. (Boris A.), Jahanshad, N. (Neda), Thompson, P.M. (Paul), Turner, J. (Jessica), Erp, T.G.M. (Theo G.) van, Walton, E. (Esther), Hibar, D.P. (Derrek P.), Schmaal, L. (Lianne), Jiang, W. (Wenhao), Glahn, D.C. (David), Pearlson, G. (Godfrey), Yao, N. (Nailin), Fukunaga, M. (Masaki), Hashimoto, R. (Ryota), Okada, N. (Naohiro), Yamamori, H. (Hidenaga), Bustillo, J., Clark, V.P., Agartz, I. (Ingrid), Mueller, B.A. (Bryon ), Cahn, W. (Wiepke), de Zwarte, S.M.C. (Sonja M.C.), Hulshoff Pol, H.E. (Hilleke), Kahn, R. (René), Ophoff, R.A. (Roel), van Haren, N.E.M. (Neeltje E.M.), Andreassen, O.A. (Ole), Dale, A.M. (Anders), Doan, N.T. (Nhat Trung), Gurholt, T.P. (Tiril P.), Hartberg, C.B. (Cecilie B.), Haukvik, U.K. (Unn), Jørgensen, K.N. (Kjetil N.), Lagerberg, T.V. (Trine V.), Melle, I. (Ingrid), Westlye, L.T. (Lars), Gruber, O. (Oliver), Kraemer, B. (Bernd), Richter, A. (Anja), Zilles, D. (David), Calhoun, V.D. (Vince), Crespo-Facorro, B. (Benedicto), Roiz-Santiañez, R. (Roberto), Tordesillas-Gutierrez, D. (Diana), Loughland, C.M. (Carmel), Carr, V.J. (Vaughan J.), Catts, S.V. (Stanley), Cropley, V.L. (Vanessa L.), Fullerton, J.M. (Janice M.), Green, M.J. (Melissa J.), Henskens, F.A. (Frans), Jablensky, A. (Assen), Lenroot, R.K. (Rhoshel), Mowry, B.J. (Bryan J), Michie, P.T. (Patricia), Pantelis, C. (Christos), Quidé, Y. (Yann), Schall, J.D. (Jeffrey), Scott, R.J. (Rodney J.), Cairns, M.J. (Murray J.), Seal, M. (Marc), Tooney, P.A. (Paul A.), Rasser, P.E. (Paul E.), Cooper, G. (Gavin), Shannon Weickert, C. (Cynthia), Weickert, T.W. (Thomas W.), Morris, D.W. (Derek W), Hong, E. (Elliot), Kochunov, P. (Peter), Beard, L.M. (Lauren M.), Gur, R.E. (Raquel), Gur, R.C. (Ruben C.), Satterthwaite, T.D. (Theodore), Wolf, D.H. (Daniel H.), Belger, A. (Aysenil), Brown, G.G. (Gregory G.), Ford, J.M. (Judith M.), Macciardi, F. (Fabio), Mathalon, D.H. (Daniel H.), O'Leary, D.S. (Daniel S.), Potkin, S.G. (Steven), Preda, A. (Adrian), Voyvodic, J. (James), Lim, K.O. (Kelvin), McEwen, S. (Sarah), Yang, F. (Fude), Tan, Y. (Yunlong), Tan, S. (Shuping), Wang, Z. (Zhiren), Fan, F. (Fengmei), Chen, J. (Jingxu), Xiang, H. (Hong), Tang, S. (Shiyou), Guo, H. (Hua), Wan, P. (Ping), Wei, D. (Dong), Bockholt, H.J., Ehrlich, S.M. (Stefan), Wolthusen, R.P.F. (Rick P.F.), King, M.D. (Margaret D.), Shoemaker, J.M. (Jody M.), Sponheim, S.R. (Scott), Haan, L. (Lieuwe) de, Koenders, L. (Laura), Machielsen, M.W.J. (Marise), Amelsvoort, T.A.M.J. (Therese) van, Veltman, D.J. (Dick), Assogna, F. (Francesca), Banaj, N. (Nerisa), de Rossi, P. (Pietro), Iorio, M. (Mariangela), Piras, F. (Fabrizio), Spalletta, G. (Gianfranco), McKenna, P.J. (Peter J.), Pomarol-Clotet, E. (Edith), Salvador, R. (Raymond), Corvin, A. (Aiden), Donohoe, D.J. (Dennis), Kelly, S. (Sinead), Whelan, C.D. (Christopher), Dickie, E.W. (Erin W.), Rotenberg, D. (David), Voineskos, A.N. (Aristotle N.), Ciufolini, S. (Simone), Radua, J. (Joaquim), Dazzan, P. (Paola), Murray, R. (Robin), Reis Marques, T. (Tiago), Simmons, A. (Andrew), Borgwardt, S. (Stefan), Egloff, L. (Laura), Harrisberger, F. (Fabienne), Riecher-Rössler, A. (Anita), Smieskova, R. (Renata), Alpert, K. (Kathryn), Wang, L. (Lei), Jönsson, E.G. (Erik), Koops, S. (Sanne), Sommer, I.E.C. (Iris E.C.), Bertolino, A. (Alessandro), Bonvino, A. (Aurora), Di Giorgio, A. (Annabella), Neilson, E. (Emma), Mayer, A.R. (Andrew R.), Stephen, J.M. (Julia M.), Kwon, J.S. (Jun Soo), Yun, J.-Y. (Je-Yeon), Cannon, D.M. (Dara), McDonald, C. (Colm), Lebedeva, I. (Irina), Tomyshev, A.S. (Alexander S.), Akhadov, T. (Tolibjohn), Kaleda, V. (Vasily), Fatouros-Bergman, H. (Helena), Flyckt, L. (Lena), Farde, L. (Lars), Engberg, G. (Göran), Erhardt, S. (Sophie), Cervenka, S. (Simon), Schwieler, L. (Lilly), Piehl, F. (Fredrik), Collste, K. (Karin), Victorsson, P. (Pauliina), Malmqvist, A. (Anna), Hedberg, M. (Mikael), Orhan, F. (Funda), Busatto, G.F. (Geraldo F.), Rosa, P.G.P. (Pedro G.P.), Serpa, M.H. (Mauricio H.), Zanetti, M.V. (Marcus V.), Hoschl, C. (Cyril), Skoch, A. (Antonin), Spaniel, F. (Filip), Tomecek, D. (David), Hagenaars, S. (Saskia), McIntosh, A.M. (Andrew), Whalley, H.C. (Heather C.), Lawrie, S. (Stephen), Knöchel, C. (Christian), Oertel-Knöchel, V. (Viola), Stäblein, M. (Michael), Howells, F.M. (Fleur M.), Stein, D.J. (Dan), Temmingh, H.S. (Henk S.), Uhlmann, A. (Anne), Lopez-Jaramillo, C. (Carlos), Dima, D. (Danai), McMahon, A. (Agnes), Faskowitz, J.I. (Joshua I.), Gutman, B.A. (Boris A.), Jahanshad, N. (Neda), Thompson, P.M. (Paul), and Turner, J. (Jessica)
- Abstract
Background: The profile of cortical neuroanatomical abnormalities in schizophrenia is not fully understood, despite hundreds of published structural brain imaging studies. This
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- 2018
- Full Text
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27. Pharmacokinetics of pamidronate in patients with bone metastases
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Leyvraz, S., Hess, U., Flesch, G., Bauer, J., Hauffe, S., Ford, J.M., and Burckhardt, P.
- Subjects
Metastasis ,Bone cancer -- Physiological aspects ,Disodium pamidronate -- Physiological aspects ,Pharmacokinetics -- Research ,Health - Abstract
Background: Pamidronate is second-generation bisphosphonate used in the treatment of tumor-induced hyper-calcemia and in the management of bone metastases from breast cancer, myeloma, or prostate cancer. The pharmacokinetics of pamidronate is unknown in cancer patients. Purpose: To determine the influence of the rate of administration and of bone metabolism, we studied the pharmacokinetics of pamidronate at three different infusion rates in 37 patient with bone metastases. Methods: Three groups of 11-14 patients were given 60 mg pamidronate as an intravenous infusion over a period of 1,4, or 24 hours. Urine groups of patients. Plasma samples were obtained only in the 1-hour infusion group. The assay of pamidronate in plasma and urine was performed by high-performance liquid chromatography with fluorescence detection after the derivatization of pamidronate with fluorescamine. Results: The body retention (BR) at 0-24 hours of pamidronate represented 60%-70% of the administered dose and was not significantly modified by the infusion rate. In particular,the BR at 0-24 hours was not reduced at the fastest infusion rate. Among patients, a threefold variability in BR at 0-24 hours occurred, which was related directly to the number of bone metastases and, the some extent, to creatinine clearance. At 60 mg/hour, the plasma kinetics followed a multiex-ponential course characterized by a short distribution phase. The mean ([+ or -] SD) half-life of the distribution phase was 0.8 hour ([+ or -]0.3), the mean ([+ or -]SD) of the area under the curve for drug concentration in plasma x time at 0-24 hours was 22.0 [+ or -] 8.8 [mu]mol/L x hours, and the mean ([+ or -]SD) of the maximum plasma concentration was 9.7 [mu]mol/L ([+ or -]32). Pharmacokinetic variables remained unchanged after repeated infusions applied to four patients. Clinically, the three infusion rates were equally well tolerated without significant toxicity. Conclusions: The 1-hour infusion rate could be proposed as kinetically appropriate for the administration of pamidronate to patients with metastatic bone diseases. [J Natl Cancer Inst 84:788-792, 1992]
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- 1992
28. The spatial chronnectome reveals a dynamic interplay between functional segregation and integration
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Iraji, A., primary, DeRamus, T.P., additional, Lewis, N., additional, Yaesoubi, M., additional, Stephen, J.M., additional, Erhardt, E., additional, Belger, A., additional, Ford, J.M., additional, McEwen, S., additional, Mathalon, D.H., additional, Mueller, B.A., additional, Pearlson, G.D., additional, Potkin, S.G., additional, Preda, A., additional, Turner, J.A., additional, Vaidya, J.G., additional, van Erp, T.G.M., additional, and Calhoun, V.D., additional
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- 2018
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29. Spatial dynamics within and between brain functional domains: A hierarchical approach to study time-varying brain function
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Iraji, A., primary, Fu, Z., additional, Damaraju, E., additional, DeRamus, T.P., additional, Lewis, N., additional, Bustillo, J.R., additional, Lenroot, R.K., additional, Belger, A., additional, Ford, J.M., additional, McEwen, S., additional, Mathalon, D.H., additional, Mueller, B.A., additional, Pearlson, G.D., additional, Potkin, S.G., additional, Preda, A., additional, Turner, J.A., additional, Vaidya, J.G., additional, van Erp, T.G.M., additional, and Calhoun, V.D., additional
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- 2018
- Full Text
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30. Climate Change as Metaphor & Catalyst: The Deeper Meaning & Potential of an Environmental Crisis
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Ford, J.M., de Cock Buning, J.T., and Science and Society
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11557
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- 2015
31. Climate Change as Metaphor & Catalyst:The Deeper Meaning & Potential of an Environmental Crisis
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Ford, J.M.
- Abstract
11557
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- 2015
32. Three-dimensional nuclear magnetic resonance imaging of green-state ceramics
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Dieckman, S.L., primary, Gopalsami, N., additional, Ford, J.M., additional, Raptis, A.C., additional, Ellingson, W.A., additional, Rizo, P., additional, Tracey, D.M., additional, and Pujari, V.K., additional
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- 1991
- Full Text
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33. Chapter 11 - Converging evidence for gamma synchrony deficits in schizophrenia
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Roach, B.J., Ford, J.M., Hoffman, R.E., and Mathalon, D.H.
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- 2013
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34. Hereditary diffuse gastric cancer: updated clinical guidelines with an emphasis on germline CDH1 mutation carriers
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Post, R.S. van der, Vogelaar, I.P., Carneiro, F., Guilford, P., Huntsman, D., Hoogerbrugge, N., Caldas, C., Schreiber, K.E., Hardwick, R.H., Ausems, M.G.E.M., Bardram, L., Benusiglio, P.R., Bisseling, T.M., Blair, V., Bleiker, E., Boussioutas, A., Cats, A., Coit, D., DeGregorio, L., Figueiredo, J., Ford, J.M., Heijkoop, E., Hermens, R.P., Humar, B., Kaurah, P., Keller, G., Lai, J., Ligtenberg, M.J., O'Donovan, M., Oliveira, C., Pinheiro, H., Ragunath, K., Rasenberg, E., Richardson, S., Roviello, F., Schackert, H., Seruca, R., Taylor, A., Huurne, A. Ter, Tischkowitz, M., Joe, S.T., Dijck, B. van, Grieken, N.C. van, Hillegersberg, R. van, Sandick, J.W. van, Vehof, M.E.J., Krieken, J.H.J.M. van, Fitzgerald, R.C., Post, R.S. van der, Vogelaar, I.P., Carneiro, F., Guilford, P., Huntsman, D., Hoogerbrugge, N., Caldas, C., Schreiber, K.E., Hardwick, R.H., Ausems, M.G.E.M., Bardram, L., Benusiglio, P.R., Bisseling, T.M., Blair, V., Bleiker, E., Boussioutas, A., Cats, A., Coit, D., DeGregorio, L., Figueiredo, J., Ford, J.M., Heijkoop, E., Hermens, R.P., Humar, B., Kaurah, P., Keller, G., Lai, J., Ligtenberg, M.J., O'Donovan, M., Oliveira, C., Pinheiro, H., Ragunath, K., Rasenberg, E., Richardson, S., Roviello, F., Schackert, H., Seruca, R., Taylor, A., Huurne, A. Ter, Tischkowitz, M., Joe, S.T., Dijck, B. van, Grieken, N.C. van, Hillegersberg, R. van, Sandick, J.W. van, Vehof, M.E.J., Krieken, J.H.J.M. van, and Fitzgerald, R.C.
- Abstract
Contains fulltext : 152968.pdf (publisher's version ) (Open Access), Germline CDH1 mutations confer a high lifetime risk of developing diffuse gastric (DGC) and lobular breast cancer (LBC). A multidisciplinary workshop was organised to discuss genetic testing, surgery, surveillance strategies, pathology reporting and the patient's perspective on multiple aspects, including diet post gastrectomy. The updated guidelines include revised CDH1 testing criteria (taking into account first-degree and second-degree relatives): (1) families with two or more patients with gastric cancer at any age, one confirmed DGC; (2) individuals with DGC before the age of 40 and (3) families with diagnoses of both DGC and LBC (one diagnosis before the age of 50). Additionally, CDH1 testing could be considered in patients with bilateral or familial LBC before the age of 50, patients with DGC and cleft lip/palate, and those with precursor lesions for signet ring cell carcinoma. Given the high mortality associated with invasive disease, prophylactic total gastrectomy at a centre of expertise is advised for individuals with pathogenic CDH1 mutations. Breast cancer surveillance with annual breast MRI starting at age 30 for women with a CDH1 mutation is recommended. Standardised endoscopic surveillance in experienced centres is recommended for those opting not to have gastrectomy at the current time, those with CDH1 variants of uncertain significance and those that fulfil hereditary DGC criteria without germline CDH1 mutations. Expert histopathological confirmation of (early) signet ring cell carcinoma is recommended. The impact of gastrectomy and mastectomy should not be underestimated; these can have severe consequences on a psychological, physiological and metabolic level. Nutritional problems should be carefully monitored.
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- 2015
35. Profiles of genome complexity identify HORMAD1 as a driver of homologous recombination deficiency and platinum therapy response in triple-negative breast cancer
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Grigoriadis, A., primary, Weekes, D., additional, Watkins, J.A., additional, Gazinska, P., additional, Frankum, J., additional, Lord, C., additional, Ashworth, A., additional, Ford, J.M., additional, Telli, M., additional, and Tutt, A., additional
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- 2015
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36. The MLH1 c.-27C>A and c.85G>T variants are linked to dominantly inherited MLH1 epimutation and are borne on a European ancestral haplotype
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Kwok, C.T., Vogelaar, I.P., Zelst-Stams, W.A.G. van, Mensenkamp, A.R., Ligtenberg, M.J.L., Rapkins, R.W., Ward, R.L., Chun, N., Ford, J.M., Ladabaum, U., McKinnon, W.C., Greenblatt, M.S., Hitchins, M.P., Kwok, C.T., Vogelaar, I.P., Zelst-Stams, W.A.G. van, Mensenkamp, A.R., Ligtenberg, M.J.L., Rapkins, R.W., Ward, R.L., Chun, N., Ford, J.M., Ladabaum, U., McKinnon, W.C., Greenblatt, M.S., and Hitchins, M.P.
- Abstract
Contains fulltext : 136957.pdf (publisher's version ) (Closed access), Germline mutations of the DNA mismatch repair genes MLH1, MSH2, MSH6 or PMS2, and deletions affecting the EPCAM gene adjacent to MSH2, underlie Lynch syndrome by predisposing to early-onset colorectal, endometrial and other cancers. An alternative but rare cause of Lynch syndrome is constitutional epimutation of MLH1, whereby promoter methylation and transcriptional silencing of one allele occurs throughout normal tissues. A dominantly transmitted constitutional MLH1 epimutation has been linked to an MLH1 haplotype bearing two single-nucleotide variants, NM_000249.2: c.-27C>A and c.85G>T, in a Caucasian family with Lynch syndrome from Western Australia. Subsequently, a second seemingly unrelated Caucasian Australian case with the same MLH1 haplotype and concomitant epimutation was reported. We now describe three additional, ostensibly unrelated, cancer-affected families of European heritage with this MLH1 haplotype in association with constitutional epimutation, bringing the number of index cases reported to five. Array-based genotyping in four of these families revealed shared haplotypes between individual families that extended across =2.6-=6.4 megabase regions of chromosome 3p, indicating common ancestry. A minimal =2.6 megabase founder haplotype common to all four families was identified, which encompassed MLH1 and additional flanking genes and segregated with the MLH1 epimutation in each family. Our findings indicate that the MLH1 c.-27C>A and c.85G>T variants are borne on a European ancestral haplotype and provide conclusive evidence for its pathogenicity via a mechanism of epigenetic silencing of MLH1 within normal tissues. Additional descendants bearing this founder haplotype may exist who are also at high risk of developing Lynch syndrome-related cancers.
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- 2014
37. Dynamic functional connectivity analysis reveals transient states of dysconnectivity in schizophrenia
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Damaraju, E., primary, Allen, E.A., additional, Belger, A., additional, Ford, J.M., additional, McEwen, S., additional, Mathalon, D.H., additional, Mueller, B.A., additional, Pearlson, G.D., additional, Potkin, S.G., additional, Preda, A., additional, Turner, J.A., additional, Vaidya, J.G., additional, van Erp, T.G., additional, and Calhoun, V.D., additional
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- 2014
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38. Modelling Interface Diffusion Creep: Single Phase Insights and Two Phase Challenges
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Wheeler, John, primary and Ford, J.M., additional
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- 2012
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39. Multimodality Therapy for Esophageal Cancer: The Benefit of Chemoradiation
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Vossler, S.R., primary, Bavan, B., additional, Kunz, P., additional, Ford, J.M., additional, Fisher, G.A., additional, Whyte, R., additional, Koong, A.C., additional, and Chang, D.T., additional
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- 2011
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40. Intensity Modulated Radiation Therapy vs. Conventional Radiation Therapy for Squamous Cell Carcinoma of the Anal Canal
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Bazan, J.G., primary, Hara, W., additional, Kunz, P., additional, Fisher, G.A., additional, Ford, J.M., additional, Welton, M.L., additional, Koong, A., additional, Shelton, A., additional, Goodman, K.A., additional, and Chang, D.T., additional
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- 2010
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41. Cyclin-dependent Kinase Inhibitor 2A (p16ink4a) Expression is Associated with Improved Survival in Patients with Pancreatic Adenocarcinoma
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Chang, D.T., primary, Pai, R., additional, Chapman, C.H., additional, Norton, J.A., additional, Visser, B., additional, Fisher, G.A., additional, Ford, J.M., additional, and Koong, A.C., additional
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- 2009
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42. Intensity Modulated Radiotherapy for Adenocarcinoma of the Pancreas
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Abelson, J.A., primary, Fisher, G.A., additional, Ford, J.M., additional, Kunz, P., additional, Norton, J.A., additional, Visser, B., additional, Koong, A.C., additional, and Chang, D.T., additional
- Published
- 2009
- Full Text
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43. Positron Emission Tomography for Predicting Pathologic Response Following Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer
- Author
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Chennupati, S.K., primary, Welton, M., additional, Shelton, A., additional, Fisher, G.A., additional, Ford, J.M., additional, Pai, R.K., additional, Quon, A., additional, Kamaya, A., additional, Koong, A.C., additional, and Chang, D.T., additional
- Published
- 2008
- Full Text
- View/download PDF
44. Phase II Trial of Gemcitabine and Single Fraction Stereotactic Body Radiotherapy (Trilogy) for the Treatment of Locally Advanced, Unresectable Adenocarcinoma of the Pancreas
- Author
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Schellenberg, D., primary, Columbo, L.A., additional, Lee, F.L., additional, Chang, S.T., additional, Fisher, G.A., additional, Ford, J.M., additional, Maxim, P.G., additional, Yang, G.P., additional, Goodman, K.A., additional, and Koong, A.C., additional
- Published
- 2007
- Full Text
- View/download PDF
45. Ductal pattern enhancement on magnetic resonance imaging of the breast due to ductal lavage
- Author
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Ghanoumi, P., primary, Kurian, A.W., additional, Marcolis, D., additional, Hartman, A.-R., additional, Mills, M.A., additional, Plevritis, S.K., additional, Ford, J.M., additional, and Daniel, B.L., additional
- Published
- 2007
- Full Text
- View/download PDF
46. 2153
- Author
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Chang, S.T., primary, Goodman, K.A., additional, Quon, A., additional, Le, Q.T., additional, Fisher, G.A., additional, Kuo, T., additional, Ford, J.M., additional, Norton, J., additional, Yang, G.P., additional, and Koong, A.C., additional
- Published
- 2006
- Full Text
- View/download PDF
47. Diffusion-creep modelling of fibrous pressure-shadows
- Author
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Berton, J.R., primary, Durney, D.W., additional, Wheeler, J., additional, and Ford, J.M., additional
- Published
- 2006
- Full Text
- View/download PDF
48. The radiation enhancer motexafin gadolinium (MGd) does not penetrate the blood brain barrier in glioblastoma multiforme patients undergoing post-operative fractionated radiation therapy
- Author
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Wu, G.N, primary, Ford, J.M, additional, and Alger, J.R, additional
- Published
- 2003
- Full Text
- View/download PDF
49. Dampened emotional reactivity in schizophrenia: ERP evidence
- Author
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Mathalon, D.H., primary, Gray, E.M., additional, Rinderknecht, T.N., additional, Faustman, W.O., additional, and Ford, J.M., additional
- Published
- 2003
- Full Text
- View/download PDF
50. Schizophrenia patients inhibit motor responses just-in-the nick-of-time: ERP and FMRI in a go/NoGo task
- Author
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Ford, J.M., primary, Whitfield, S.L., additional, Gray, E.M., additional, Faustman, W.O., additional, Turken, A.U., additional, Glover, G., additional, and Mathalon, D.H., additional
- Published
- 2003
- Full Text
- View/download PDF
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