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1. The Bethesda ERCP Skills Assessment Tool (BESAT) can reliably differentiate endoscopists of different experience levels.

Author

Liu, Kevin, Elmunzer, B, Wani, Sachin, Taft, Tiffany, Walsh, Catharine, Arain, Mustafa, Berzin, Tyler, Buxbaum, James, DiMaio, Christopher, Fehmi, Syed, Gupta, Neil, Jonnalagadda, Sreenivasa, Kushnir, Vladimir, Maple, John, Muthusamy, Raman, Rastogi, Amit, Shah, Janak, Chak, Amitabh, Faulx, Ashley, Forbes, Nauzer, and Keswani, Rajesh

Subjects
ERC topics, Pancreatobiliary (ERCP/PTCD), Quality and logistical aspects, Quality management, Training
Abstract

Background and study aims The Bethesda ERCP Skill Assessment Tool (BESAT) is a video-based assessment tool of technical endoscopic retrograde cholangiopancreatography (ERCP) skill with previously established validity evidence. We aimed to assess the discriminative validity of the BESAT in differentiating ERCP skill levels. Methods Twelve experienced ERCP practitioners from tertiary academic centers were asked to blindly rate 43 ERCP videos using the BESAT. ERCP videos consisted of native biliary cannulation and sphincterotomy and were recorded from 10 unique endoscopists of various ERCP experience (from advanced endoscopy fellow to > 10 years of ERCP experience). Inter-rater reliability, discriminative validity, and internal structure validity were subsequently assessed. Results The BESAT was found to reliably differentiate between endoscopists of varying levels of ERCP experience with experienced ERCPists scoring higher than novice ERCPists in 11 of 13 (85%) instrument items. Inter-rater reliability for BESAT items ranged from good to excellent (intraclass correlation range: 0.86 to 0.93). Internal structure validity was assessed with item-total correlations ranging from 0.53 to 0.83. Conclusions Study findings demonstrate that the BESAT, a video-based ERCP skill assessment tool, has high inter-rater reliability and has discriminative validity in differentiating novice from expert ERCP skill. Further investigations are needed to determine the role of video-based assessment in improving trainee learning curves and patient outcomes.

Published
2024

2. American Society for Gastrointestinal Endoscopy guideline on role of endoscopy in the diagnosis and management of solid pancreatic masses: methodology and review of evidence

Author

Machicado, Jorge D., Sheth, Sunil G., Chalhoub, Jean M., Forbes, Nauzer, Desai, Madhav, Ngamruengphong, Saowanee, Papachristou, Georgios I., Sahai, Vaibhav, Nassour, Ibrahim, Abidi, Wasif, Alipour, Omeed, Amateau, Stuart K., Coelho-Prabhu, Nayantara, Cosgrove, Natalie, Elhanafi, Sherif E., Fujii-Lau, Larissa L., Kohli, Divyanshoo R., Marya, Neil B., Pawa, Swati, Ruan, Wenly, Thiruvengadam, Nikhil R., Thosani, Nirav C., and Qumseya, Bashar J.

Published
2024
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3. American Society for Gastrointestinal Endoscopy guideline on the role of endoscopy in the diagnosis and management of solid pancreatic masses: summary and recommendations

Author

Machicado, Jorge D., Sheth, Sunil G., Chalhoub, Jean M., Forbes, Nauzer, Desai, Madhav, Ngamruengphong, Saowanee, Papachristou, Georgios I., Sahai, Vaibhav, Nassour, Ibrahim, Abidi, Wasif, Alipour, Omeed, Amateau, Stuart K., Coelho-Prabhu, Nayantara, Cosgrove, Natalie, Elhanafi, Sherif E., Fujii-Lau, Larissa L., Kohli, Divyanshoo R., Marya, Neil B., Pawa, Swati, Ruan, Wenly, Thiruvengadam, Nikhil R., Thosani, Nirav C., and Qumseya, Bashar J.

Published
2024
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4. American Society for Gastrointestinal Endoscopy guideline on the role of endoscopy in the management of chronic pancreatitis: summary and recommendations

Author

Sheth, Sunil G., Machicado, Jorge D., Chalhoub, Jean M., Forsmark, Christopher, Zyromski, Nicholas, Thosani, Nirav C., Thiruvengadam, Nikhil R., Ruan, Wenly, Pawa, Swati, Ngamruengphong, Saowanee, Marya, Neil B., Kohli, Divyanshoo R., Fujii-Lau, Larissa L., Forbes, Nauzer, Elhanafi, Sherif E., Desai, Madhav, Cosgrove, Natalie, Coelho-Prabhu, Nayantara, Amateau, Stuart K., Alipour, Omeed, Abidi, Wasif, and Qumseya, Bashar J.

Published
2024
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6. Factors Associated with the Development of Gastrointestinal Symptoms in Patients Hospitalized with Covid-19.

Author

Aroniadis, Olga, Wang, Xianling, Gong, Tang, Forbes, Nauzer, Yang, Jeong, Canakis, Andrew, Elmunzer, Badih, and Yadav, Dhiraj

Subjects
Characteristics, Covid-19, Gastrointestinal symptoms, Adult, COVID-19, Canada, Case-Control Studies, Diarrhea, Gastrointestinal Diseases, Humans, SARS-CoV-2
Abstract

BACKGROUND AND AIMS: The most common symptoms of Covid-19 are respiratory; however, gastrointestinal symptoms are present in up to 50% of patients. We aimed to determine characteristics associated with the development of gastrointestinal symptoms in patients with Covid-19. METHODS: A case-control study of adults hospitalized for Covid-19 was conducted across a geographically diverse alliance of 36 US and Canadian medical centers. Data were manually abstracted from electronic health records and analyzed using regression analyses to determine characteristics associated with any gastrointestinal symptoms and diarrhea specifically. RESULTS: Of 1406 patients, 540 (38%) reported at least one gastrointestinal symptom and 346 (25%) reported diarrhea. Older patients (≥ 80 years) had significantly lower rates of any gastrointestinal symptoms and diarrhea (vs. patients 18-79 years, OR 0.41, p

Published
2022

9. Prolonged Gastrointestinal Manifestations After Recovery From COVID-19

Author

Elmunzer, B. Joseph, Palsson, Olafur S., Forbes, Nauzer, Zakaria, Ali, Davis, Christian, Canakis, Andrew, Qayed, Emad, Bick, Benjamin, Pawa, Swati, Tierney, William M., McLeod, Caroline G., Taylor, Jason, Patel, Harsh, Mendelsohn, Robin B., Bala, Gokul, Sloan, Ian, Merchant, Ambreen A., Smith, Zachary L., Sendzischew Shane, Morgan A., Aroniadis, Olga C., Ordiah, Collins O., Ruddy, Johannah M., Simren, Magnus, Tack, Jan, and Drossman, Douglas

Published
2024
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10. Post-ERCP cholecystitis: Incidence, characteristics, and outcomes from a prospective multicenter biliary endoscopy registry

Author

Khan, Rishad, Osman, Hana, Lee, Sangmin, Chen, Yen-I, Singh, Andrew, Hookey, Lawrence, Arya, Naveen, Causada Calo, Natalia, Grover, Samir C., Tepox-Padrón, Alejandra, Bass, Sydney, Cole, Martin, Lei, Yang, Li, Suqing, Mohamed, Rachid, Turbide, Christian, Koury, Hannah F., Chau, Millie, Howarth, Megan, Cartwright, Shane, Heitman, Steven J., and Forbes, Nauzer

Published
2024
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11. Aspirin exposure and its association with metal stent patency in malignant distal biliary obstruction: a large international multicenter propensity score–matched study

Author

Candido, Kristina, Bouchard, Simon, Hansen-Barkun, Christopher, Huang, Dora C., Chatterjee, Avijit, Menard, Charles, Miller, Corey, Sandha, Gurpal, Donnellan, Fergal, Telford, Jennifer, Desilets, Etienne, Forbes, Nauzer, Roy, Andre, Calo, Natalia, Gan, Ian, Lam, Eric, Pleskow, Douglas, Chen Kiow, Jeremy Liu, Sarker, Avi, Cadieux-Genesse, Etienne, Jain, Avni, Louis, Felix, Bilal, Mohammad, Sene, Pape-Mamadou, Fairclough, Jehovan, Reuangrith, Jacqueline, Benmassaoud, Amine, Geraci, Olivia, Martel, Myriam, and Chen, Yen-I

Published
2024
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13. Indomethacin with or without prophylactic pancreatic stent placement to prevent pancreatitis after ERCP: a randomised non-inferiority trial

Author

Elmunzer, B. Joseph, Foster, Lydia D., Serrano, Jose, Coté, Gregory A., Edmundowicz, Steven A., Wani, Sachin, Shah, Raj, Bang, Ji Young, Varadarajulu, Shyam, Singh, Vikesh K., Khashab, Mouen, Kwon, Richard S., Scheiman, James M., Willingham, Field F., Keilin, Steven A., Papachristou, Georgios I., Chak, Amitabh, Slivka, Adam, Mullady, Daniel, Kushnir, Vladimir, Buxbaum, James, Keswani, Rajesh, Gardner, Timothy B., Forbes, Nauzer, Rastogi, Amit, Ross, Andrew, Law, Joanna, Yachimski, Patrick, Chen, Yen-I, Barkun, Alan, Smith, Zachary L., Petersen, Bret, Wang, Andrew Y., Saltzman, John R., Spitzer, Rebecca L., Ordiah, Collins, Spino, Cathie, Higgins, Peter D.R., Forster, Erin, Moran, Robert A., Brauer, Brian, Wamsteker, Erik J., Cai, Qiang, Qayed, Emad, Groce, Royce, Krishna, Somashekar G., Faulx, Ashley, Glessing, Brooke, Rabinovitz, Mordechai, Lang, Gabriel, Aadam, Aziz, Komanduri, Srinadh, Adler, Jefferey, Gordon, Stuart, Mohamed, Rachid, Olyaee, Mojtaba, Wood-Williams, April, Depue Brewbaker, Emily K., Thornhill, Andre, Gould, Mariana, Clasen, Kristen, Olsen, Jama, Simon, Violette C., Kamal, Ayesha, Volk, Sarah L., Merchant, Ambreen A., Lahooti, Ali, Furey, Nancy, Anderson, Gulsum, Hollander, Thomas, Vazquez, Alejandro, Li, Thomas Y., Hadley, Steven M., Chau, Millie, Mendoza, Robinson, Tangwongchai, Tida, Koza, Casey L., Geraci, Olivia, Nunez, Lizbeth, Waters, Alexander M., Durkalski-Mauldin, Valerie, Elmunzer, B Joseph, Foster, Lydia D, Coté, Gregory A, Edmundowicz, Steven A, Singh, Vikesh K, Kwon, Richard S, Scheiman, James M, Willingham, Field F, Keilin, Steven A, Papachristou, Georgios I, Gardner, Timothy B, Smith, Zachary L, Wang, Andrew Y, Saltzman, John R, and Spitzer, Rebecca L

Published
2024
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14. Trainee Participation and Outcomes in High-risk Endoscopic Retrograde Cholangiopancreatography: A Secondary Analysis of the Stent Versus Indomethacin Trial

Author

Serrano, Jose, Coté, Gregory A., Edmundowicz, Steven A., Shah, Raj, Bang, Ji Young, Varadarajulu, Shyam, Singh, Vikesh K., Khashab, Mouen, Kwon, Richard S., Scheiman, James M., Willingham, Field F., Keilin, Steven A., Papachristou, Georgios I., Chak, Amitabh, Slivka, Adam, Mullady, Daniel, Kushnir, Vladimir, Buxbaum, James, Keswani, Rajesh, Gardner, Timothy B., Forbes, Nauzer, Rastogi, Amit, Ross, Andrew, Law, Joanna, Yachimski, Patrick, Chen, Yen-I, Barkun, Alan, Smith, Zachary L., Petersen, Bret, Wang, Andrew Y., Saltzman, John R., Spitzer, Rebecca L., Gallegos, Jazmyne, Brennan, Case, Ordiah, Collins, Spino, Cathie, Wani, Sachin, Zhang, Jingwen, Foster, Lydia D., Durkalski-Mauldin, Valerie, and Elmunzer, B. Joseph

Published
2024
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15. American Society for Gastrointestinal Endoscopy guideline on the role of therapeutic EUS in the management of biliary tract disorders: summary and recommendations

Author

Pawa, Swati, Marya, Neil B., Thiruvengadam, Nikhil R., Ngamruengphong, Saowanee, Baron, Todd H., Bun Teoh, Anthony Yuen, Bent, Christopher K., Abidi, Wasif, Alipour, Omeed, Amateau, Stuart K., Desai, Madhav, Chalhoub, Jean M., Coelho-Prabhu, Nayantara, Cosgrove, Natalie, Elhanafi, Sherif E., Forbes, Nauzer, Fujii-Lau, Larissa L., Kohli, Divyanshoo R., Machicado, Jorge D., Navaneethan, Udayakumar, Ruan, Wenly, Sheth, Sunil G., Thosani, Nirav C., and Qumseya, Bashar J.

Published
2024
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17. Digestive Manifestations in Patients Hospitalized With Coronavirus Disease 2019.

Author

Elmunzer, B, Spitzer, Rebecca, Foster, Lydia, Merchant, Ambreen, Howard, Eric, Patel, Vaishali, West, Mary, Qayed, Emad, Nustas, Rosemary, Zakaria, Ali, Piper, Marc, Taylor, Jason, Jaza, Lujain, Forbes, Nauzer, Chau, Millie, Lara, Luis, Papachristou, Georgios, Volk, Michael, Hilson, Liam, Zhou, Selena, Kushnir, Vladimir, Lenyo, Alexandria, McLeod, Caroline, Amin, Sunil, Kuftinec, Gabriela, Yadav, Dhiraj, Fox, Charlie, Kolb, Jennifer, Pawa, Swati, Pawa, Rishi, Canakis, Andrew, Huang, Christopher, Jamil, Laith, Aneese, Andrew, Glamour, Benita, Smith, Zachary, Hanley, Katherine, Wood, Jordan, Patel, Harsh, Shah, Janak, Agarunov, Emil, Sethi, Amrita, Fogel, Evan, McNulty, Gail, Haseeb, Abdul, Trieu, Judy, Dixon, Rebekah, Yang, Jeong, Mendelsohn, Robin, Calo, Delia, Aroniadis, Olga, LaComb, Joseph, Scheiman, James, Sauer, Bryan, Dang, Duyen, Piraka, Cyrus, Shah, Eric, Pohl, Heiko, Tierney, William, Mitchell, Stephanie, Condon, Ashwinee, Lenhart, Adrienne, Dua, Kulwinder, Kanagala, Vikram, Kamal, Ayesha, Singh, Vikesh, Pinto-Sanchez, Maria, Hutchinson, Joy, Kwon, Richard, Korsnes, Sheryl, Singh, Harminder, Solati, Zahra, Willingham, Field, Yachimski, Patrick, Conwell, Darwin, Mosier, Evan, Azab, Mohamed, Patel, Anish, Buxbaum, James, Wani, Sachin, Chak, Amitabh, Hosmer, Amy, Keswani, Rajesh, DiMaio, Christopher, Bronze, Michael, Muthusamy, Raman, Canto, Marcia, Gjeorgjievski, V, Imam, Zaid, Odish, Fadi, Edhi, Ahmed, Orosey, Molly, Tiwari, Abhinav, Patwardhan, Soumil, Brown, Nicholas, Ordiah, Collins, Sloan, Ian, Cruz, Lilian, and Koza, Casey

Subjects
COVID-19, Digestive Manifestations, Gastrointestinal Symptoms, Hepatic Manifestations, SARS-CoV-2, Adolescent, Adult, Aged, Aged, 80 and over, COVID-19, Female, Gastrointestinal Diseases, Humans, Male, Middle Aged, North America, Young Adult
Abstract

BACKGROUND & AIMS: The prevalence and significance of digestive manifestations in coronavirus disease 2019 (COVID-19) remain uncertain. We aimed to assess the prevalence, spectrum, severity, and significance of digestive manifestations in patients hospitalized with COVID-19. METHODS: Consecutive patients hospitalized with COVID-19 were identified across a geographically diverse alliance of medical centers in North America. Data pertaining to baseline characteristics, symptomatology, laboratory assessment, imaging, and endoscopic findings from the time of symptom onset until discharge or death were abstracted manually from electronic health records to characterize the prevalence, spectrum, and severity of digestive manifestations. Regression analyses were performed to evaluate the association between digestive manifestations and severe outcomes related to COVID-19. RESULTS: A total of 1992 patients across 36 centers met eligibility criteria and were included. Overall, 53% of patients experienced at least 1 gastrointestinal symptom at any time during their illness, most commonly diarrhea (34%), nausea (27%), vomiting (16%), and abdominal pain (11%). In 74% of cases, gastrointestinal symptoms were judged to be mild. In total, 35% of patients developed an abnormal alanine aminotransferase or total bilirubin level; these were increased to less than 5 times the upper limit of normal in 77% of cases. After adjusting for potential confounders, the presence of gastrointestinal symptoms at any time (odds ratio, 0.93; 95% CI, 0.76-1.15) or liver test abnormalities on admission (odds ratio, 1.31; 95% CI, 0.80-2.12) were not associated independently with mechanical ventilation or death. CONCLUSIONS: Among patients hospitalized with COVID-19, gastrointestinal symptoms and liver test abnormalities were common, but the majority were mild and their presence was not associated with a more severe clinical course.

Published
2021

19. American Society for Gastrointestinal Endoscopy guideline on the role of endoscopy in the diagnosis of malignancy in biliary strictures of undetermined etiology: summary and recommendations

Author

Fujii-Lau, Larissa L., Thosani, Nirav C., Al-Haddad, Mohammad, Acoba, Jared, Wray, Curtis J., Zvavanjanja, Rodrick, Amateau, Stuart K., Buxbaum, James L., Calderwood, Audrey H., Chalhoub, Jean M., Coelho-Prabhu, Nayantara, Desai, Madhav, Elhanafi, Sherif E., Fishman, Douglas S., Forbes, Nauzer, Jamil, Laith H., Jue, Terry L., Kohli, Divyanshoo R., Kwon, Richard S., Law, Joanna K., Lee, Jeffrey K., Machicado, Jorge D., Marya, Neil B., Pawa, Swati, Ruan, Wenly, Sawhney, Mandeep S., Sheth, Sunil G., Storm, Andrew, Thiruvengadam, Nikhil R., and Qumseya, Bashar J.

Published
2023
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20. American Society for Gastrointestinal Endoscopy guideline on role of endoscopy in the diagnosis of malignancy in biliary strictures of undetermined etiology: methodology and review of evidence

Author

Fujii-Lau, Larissa L., Thosani, Nirav C., Al-Haddad, Mohammad, Acoba, Jared, Wray, Curtis J., Zvavanjanja, Rodrick, Amateau, Stuart K., Buxbaum, James L., Wani, Sachin, Calderwood, Audrey H., Chalhoub, Jean M., Coelho-Prabhu, Nayantara, Desai, Madhav, Elhanafi, Sherif E., Fishman, Douglas S., Forbes, Nauzer, Jamil, Laith H., Jue, Terry L., Kohli, Divyanshoo R., Kwon, Richard S., Law, Joanna K., Lee, Jeffrey K., Machicado, Jorge D., Marya, Neil B., Pawa, Swati, Ruan, Wenly, Sawhney, Mandeep S., Sheth, Sunil G., Storm, Andrew, Thiruvengadam, Nikhil R., and Qumseya, Bashar J.

Published
2023
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21. Endoscopic Ultrasound-Guided Biliary Drainage of First Intent With a Lumen-Apposing Metal Stent vs Endoscopic Retrograde Cholangiopancreatography in Malignant Distal Biliary Obstruction: A Multicenter Randomized Controlled Study (ELEMENT Trial)

Author

Chen, Yen-I, Sahai, Anand, Donatelli, Gianfranco, Lam, Eric, Forbes, Nauzer, Mosko, Jeffrey, Paquin, Sarto C., Donnellan, Fergal, Chatterjee, Avijit, Telford, Jennifer, Miller, Corey, Desilets, Etienne, Sandha, Gurpal, Kenshil, Sana, Mohamed, Rachid, May, Gary, Gan, Ian, Barkun, Jeffrey, Calo, Natalia, Nawawi, Abrar, Friedman, Gad, Cohen, Albert, Maniere, Thibaut, Chaudhury, Prosanto, Metrakos, Peter, Zogopoulos, George, Bessissow, Ali, Khalil, Jad Abou, Baffis, Vicky, Waschke, Kevin, Parent, Josee, Soulellis, Constantine, Khashab, Mouen, Kunda, Rastislav, Geraci, Olivia, Martel, Myriam, Schwartzman, Kevin, Fiore, Julio F., Jr., Rahme, Elham, and Barkun, Alan

Published
2023
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22. American Society for Gastrointestinal Endoscopy guideline on the role of ergonomics for prevention of endoscopy-related injury: summary and recommendations

Author

Pawa, Swati, Kwon, Richard S., Fishman, Douglas S., Thosani, Nirav C., Shergill, Amandeep, Grover, Samir C., Al-Haddad, Mohammad, Amateau, Stuart K., Buxbaum, James L., Calderwood, Audrey H., Chalhoub, Jean M., Coelho-Prabhu, Nayantara, Desai, Madhav, Elhanafi, Sherif E., Forbes, Nauzer, Fujii-Lau, Larissa L., Kohli, Divyanshoo R., Machicado, Jorge D., Marya, Neil B., Ruan, Wenly, Sheth, Sunil G., Storm, Andrew C., Thiruvengadam, Nikhil R., and Qumseya, Bashar J.

Published
2023
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23. American Society for Gastrointestinal Endoscopy guideline on the role of ergonomics for prevention of endoscopy-related injury: methodology and review of evidence

Author

Pawa, Swati, Kwon, Richard S., Fishman, Douglas S., Thosani, Nirav C., Shergill, Amandeep, Grover, Samir C., Al-Haddad, Mohammad, Amateau, Stuart K., Buxbaum, James L., Calderwood, Audrey H., Chalhoub, Jean M., Coelho-Prabhu, Nayantara, Desai, Madhav, Elhanafi, Sherif E., Forbes, Nauzer, Fujii-Lau, Larissa L., Kohli, Divyanshoo R., Machicado, Jorge D., Marya, Neil B., Ruan, Wenly, Sheth, Sunil G., Storm, Andrew C., Thiruvengadam, Nikhil R., Wani, Sachin, and Qumseya, Bashar J.

Published
2023
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25. American Society for Gastrointestinal Endoscopy guideline on endoscopic submucosal dissection for the management of early esophageal and gastric cancers: methodology and review of evidence

Author

Al-Haddad, Mohammad A., Elhanafi, Sherif E., Forbes, Nauzer, Thosani, Nirav C., Draganov, Peter V., Othman, Mohamed O., Ceppa, Eugene P., Kaul, Vivek, Feely, Michael M., Sahin, Ilyas, Ruan, Yibing, Sadeghirad, Behnam, Morgan, Rebecca L., Buxbaum, James L., Calderwood, Audrey H., Chalhoub, Jean M., Coelho-Prabhu, Nayantara, Desai, Madhav, Fujii-Lau, Larissa L., Kohli, Divyanshoo R., Kwon, Richard S., Machicado, Jorge D., Marya, Neil B., Pawa, Swati, Ruan, Wenly, Sheth, Sunil G., Storm, Andrew C., Thiruvengadam, Nikhil R., and Qumseya, Bashar J.

Published
2023
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26. American Society for Gastrointestinal Endoscopy guideline on endoscopic submucosal dissection for the management of early esophageal and gastric cancers: summary and recommendations

Author

Forbes, Nauzer, Elhanafi, Sherif E., Al-Haddad, Mohammad A., Thosani, Nirav C., Draganov, Peter V., Othman, Mohamed O., Ceppa, Eugene P., Kaul, Vivek, Feely, Michael M., Sahin, Ilyas, Buxbaum, James L., Calderwood, Audrey H., Chalhoub, Jean M., Coelho-Prabhu, Nayantara, Desai, Madhav, Fujii-Lau, Larissa L., Kohli, Divyanshoo R., Kwon, Richard S., Machicado, Jorge D., Marya, Neil B., Pawa, Swati, Ruan, Wenly, Sheth, Sunil G., Storm, Andrew C., Thiruvengadam, Nikhil R., and Qumseya, Bashar J.

Published
2023
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28. American Society for Gastrointestinal Endoscopy guideline on management of post–liver transplant biliary strictures: summary and recommendations

Author

Kohli, Divyanshoo R., Amateau, Stuart K., Desai, Madhav, Chinnakotla, Srinath, Harrison, M. Edwyn, Chalhoub, Jean M., Coelho-Prabhu, Nayantara, Elhanafi, Sherif E., Forbes, Nauzer, Fujii-Lau, Larissa L., Kwon, Richard S., Machicado, Jorge D., Marya, Neil B., Pawa, Swati, Ruan, Wenly, Sheth, Sunil G., Thiruvengadam, Nikhil R., Thosani, Nirav C., and Qumseya, Bashar J.

Published
2023
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29. American Society for Gastrointestinal Endoscopy guideline on management of post–liver transplant biliary strictures: methodology and review of evidence

Author

Amateau, Stuart K., Kohli, Divyanshoo R., Desai, Madhav, Chinnakotla, Srinath, Harrison, M. Edwyn, Chalhoub, Jean M., Coelho-Prabhu, Nayantara, Elhanafi, Sherif E., Forbes, Nauzer, Fujii-Lau, Larissa L., Kwon, Richard S., Machicado, Jorge D., Marya, Neil B., Pawa, Swati, Ruan, Wenly, Sheth, Sunil G., Thiruvengadam, Nikhil R., Thosani, Nirav C., and Qumseya, Bashar J.

Published
2023
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30. EAES rapid guideline: updated systematic review, network meta-analysis, CINeMA and GRADE assessment, and evidence-informed European recommendations on the management of common bile duct stones

Author

Boni, Luigi, Huo, Bright, Alberici, Laura, Ricci, Claudio, Tsokani, Sofia, Mavridis, Dimitris, Amer, Yasser Sami, Andreou, Alexandros, Berriman, Thomas, Donatelli, Gianfranco, Forbes, Nauzer, Kapiris, Stylianos, Kayaalp, Cüneyt, Kylänpää, Leena, Parra-Membrives, Pablo, Siersema, Peter D., Black, George F., and Antoniou, Stavros A.

Published
2022
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36. A computer-aided detection system in the everyday setting of diagnostic, screening, and surveillance colonoscopy: an international, randomized trial.

Author

Maas, Michiel H. J., Rath, Timo, Spada, Cristiano, Soons, Elsa, Forbes, Nauzer, Kashin, Sergey, Cesaro, Paola, Eickhoff, Axel, Vanbiervliet, Geoffroy, Salvi, Daniele, Belletrutti, Paul J., and Siersema, Peter D.

Abstract

Background Computer-aided detection (CADe) has been developed to improve detection during colonoscopy. After initial reports of high efficacy, there has been an increasing recognition of variability in the effectiveness of CADe systems. The aim of this study was to evaluate a CADe system in a varied colonoscopy population. Methods A multicenter, randomized trial was conducted at seven hospitals (both university and non-university) in Europe and Canada. Participants referred for diagnostic, non-immunochemical fecal occult blood test (iFOBT) screening, or surveillance colonoscopy were randomized (1:1) to undergo CADe-assisted or conventional colonoscopy by experienced endoscopists. Participants with insufficient bowel preparation were excluded from the analysis. The primary outcome was adenoma detection rate (ADR). Secondary outcomes included adenomas per colonoscopy (APC) and sessile serrated lesions (SSLs) per colonoscopy. Results 581 participants were enrolled, of whom 497 were included in the final analysis: 250 in the CADe arm and 247 in the conventional colonoscopy arm. The indication was surveillance in 202/497 colonoscopies (40.6 %), diagnostic in 199/497 (40.0 %), and non-iFOBT screening in 96/497 (19.3 %). Overall, ADR (38.4 % vs. 37.7 %; P = 0.43) and APC (0.66 vs. 0.66; P = 0.97) were similar between CADe and conventional colonoscopy. SSLs per colonoscopy was increased (0.30 vs. 0.19; P = 0.049) in the CADe arm vs. the conventional colonoscopy arm. Conclusions In this study conducted by experienced endoscopists, CADe did not result in a statistically significant increase in ADR. However, the ADR of our control group substantially surpassed our sample size assumptions, increasing the risk of an underpowered trial. [ABSTRACT FROM AUTHOR]

Published
2024
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37. Incidence and predictors of major gastrointestinal bleeding in patients on aspirin, low‐dose rivaroxaban, or the combination: Secondary analysis of the COMPASS randomised controlled trial.

Author

Forbes, Nauzer, Yi, Qilong, Moayyedi, Paul, Bosch, Jackie, Bhatt, Deepak L., Fox, Keith A. A., and Eikelboom, John W.

Subjects
*ORAL medication, *DIVERTICULOSIS, *RANDOMIZED controlled trials, *PEPTIC ulcer, *GASTROINTESTINAL hemorrhage
Abstract

Summary: Background: The incidence of major gastrointestinal bleeding (GIB) in patients on low‐dose direct‐acting oral anticoagulants (DOACs) is relatively unknown. Estimates from randomised controlled trials (RCTs) are lacking. Aims: To assess GIB incidence and predictors from RCT data of patients on aspirin, low‐dose rivaroxaban, or both. Methods: This was a secondary analysis of RCT data wherein patients received aspirin 100 mg daily and rivaroxaban 2.5 mg b.d., aspirin alone, or rivaroxaban 5 mg b.d. Patients were followed from 2013 to 2016 at 602 centres. Outcomes included overall, upper, and lower GIB. We employed multivariable logistic regression to yield odds ratios (ORs) and 95% confidence intervals for potential exposures. Results: Among 27,395 patients, the annual incidence of GIB on rivaroxaban 2.5 mg b.d. with aspirin was 801.7 per 100,000 compared with 372.3 in 100,000 for aspirin. Age (OR 4.16, 2.53–6.82 for ≥75 vs. 55–64), peptic ulcer disease (PUD, OR 1.57, 1.01–2.44), liver disease (OR 2.09, 1.01–4.33), hypertension (OR 1.42, 1.04–1.94), and smoking (OR 1.85, 1.26–2.73) were associated with overall GIB. Kidney disease (OR 1.68, 1.12–2.51) was significantly associated with upper GIB, whereas diverticular disease (OR 3.75, 1.88–7.49) was associated with lower GIB. Addition of rivaroxaban to aspirin was associated more with lower GIB (OR 2.82, 1.64–4.84) than upper GIB (OR 1.86, 1.18–2.92). Conclusions: We established incidences and identified risk factors for GIB in users of low‐dose DOACs. Novel risk factors included current or former smoking and diverticulosis. Future studies should aim to validate these risk factors. [ABSTRACT FROM AUTHOR]

Published
2024
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38. American Society for Gastrointestinal Endoscopy guideline on informed consent for GI endoscopic procedures

Author

Storm, Andrew C., Fishman, Douglas S., Buxbaum, James L., Coelho-Prabhu, Nayantara, Al-Haddad, Mohammad A., Amateau, Stuart K., Calderwood, Audrey H., DiMaio, Christopher J., Elhanafi, Sherif E., Forbes, Nauzer, Fujii-Lau, Larissa L., Jue, Terry L., Kohli, Divyanshoo R., Kwon, Richard S., Law, Joanna K., Pawa, Swati, Thosani, Nirav C., Wani, Sachin, and Qumseya, Bashar J.

Published
2022
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44. Association Between Preadmission Acid Suppressive Medication Exposure and Severity of Illness in Patients Hospitalized With COVID-19

Author

Merchant, Ambreen A., Patel, Vaishali A., Willingham, Field F., Howard, Eric F., West, Mary K., Koza, Casey L., Yachimski, Patrick S., Qayed, Emad, Nustas, Rosemary, Zakaria, Ali, Piper, Marc S., Jaza, Lujain, Forbes, Nauzer, Chau, Millie, Lara, Luis F., Papachristou, Georgios I., Okafor, Uchechi, Conwell, Darwin L., Volk, Michael L., Mosier, Evan, Azab, Mohamed, Patel, Anish, Hilson, Liam G., Zhou, Selena, Buxbaum, James, Kushnir, Vladimir M., Lenyo, Alexandria M., Sloan, Ian P., Hollander, Thomas, McLeod, Caroline G., Spitzer, Rebecca L., Wakefield, Lauren, Nitchie, Haley, Ordiah, Collins O., Rockey, Don C., Alford, Teldon B., Amin, Sunil, Kuftinec, Gabriela N., Deshpande, Amar R., Yadav, Dhiraj, Saul, Melissa, Mays, Melanie, Anderson, Gulsum, Wood, Kelley, Mathews, Laura, Fox, Charlie, Kolb, Jennifer M., Wani, Sachin, Pawa, Swati, Pawa, Rishi, Canakis, Andrew, Huang, Christopher, Jamil, Laith H., Aneese, Andrew M., Gjeorgjievski, V. Mihajlo, Imam, Zaid, Odish, Fadi, Edhi, Ahmed I., Orosey, Molly, Tiwari, Abhinav, Patwardhan, Soumil, Glamour, Benita K., Smith, Zachary L., Hosmer, Amy E., Furey, Nancy, Chak, Amitabh, Hanley, Katherine A., Wood, Jordan, Keswani, Rajesh N., Patel, Harsh K., Shah, Janak N., Agarunov, Emil, Brown, Nicholas G., Patel, Anish A., Sethi, Amrita, Fogel, Evan L., McNulty, Gail, Haseeb, Abdul, Trieu, Judy A., Dixon, Rebekah E., Yang, Jeong Yun, DiMaio, Christopher J., Mendelsohn, Robin B., Calo, Delia, Aroniadis, Olga C., LaComb, Joseph F., Cruz, Lilian, Reykhart, Olga, Sauer, Bryan G., Diakova, Galina, Dang, Duyen T., Piraka, Cyrus R., Shah, Eric D., Caisse, Molly, Zbib, Natalia H., Damianos, John A., Pohl, Heiko, Mitchell, Stephanie, Bronze, Michael S., Condon, Ashwinee, Lenhart, Adrienne, Muthusamy, Raman, Dua, Kulwinder S., Kanagala, Vikram S., Esteban, James, Kamal, Ayesha, Canto, Marcia I., Singh, Vikesh K., Pinto-Sanchez, Maria Ines, Hutchinson, Joy M., Kwon, Richard S., Korsnes, Sheryl J., Waljee, Akbar K., Tang, Weijing, Zhang, Yueyang, Zhu, Ji, Singh, Harminder, Solati, Zahra, Hajidiacos, Nick, Elmunzer, B. Joseph, Wolf, Bethany J., Scheiman, James M., Tierney, William M., and Taylor, Jason R.

Published
2021
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46. A computer-aided detection system in the everyday setting of diagnostic, screening, and surveillance colonoscopy:an international, randomized trial

Author

Maas, Michiel H. J., Rath, Timo, Spada, Cristiano, Soons, Elsa, Forbes, Nauzer, Kashin, Sergey, Cesaro, Paola, Eickhoff, Axel, Vanbiervlie, Geoffroy, Salvi, Daniele, Belletrutti, Paul J., Siersema, Peter D., Maas, Michiel H. J., Rath, Timo, Spada, Cristiano, Soons, Elsa, Forbes, Nauzer, Kashin, Sergey, Cesaro, Paola, Eickhoff, Axel, Vanbiervlie, Geoffroy, Salvi, Daniele, Belletrutti, Paul J., and Siersema, Peter D.

Abstract

Background and study aim: Computer-aided detection (CADe) has been developed to improve detection during colonoscopy. After initial reports of high efficacy, there has been an increasing recognition of variability in the effectiveness of CADe systems. The aim of this study was to evaluate a CADe system (PENTAX Medical, Tokyo, Japan) in a varied colonoscopy population. Patients and methods: A multicenter, randomized trial was conducted at 7 hospitals (both university and non-university) in Europe and Canada. Participants referred for diagnostic, non-iFOBT screening, or surveillance colonoscopy were randomized (1:1) to undergo CADe-assisted or conventional colonoscopy (CC) by experienced endoscopists. Participants with insufficient bowel preparation were excluded from the analysis. Primary outcome was adenoma detection rate (ADR). Secondary outcomes included adenomas per colonoscopy (APC) and sessile serrated lesions per colonoscopy (SSLPC). Results: In total, 581 participants were enrolled, of which 497 were included in the final analysis: 250 in the CADe-arm and 247 in the CC-arm. Surveillance was the indication in 202/497 (40.6%) colonoscopies, diagnostic in 199/497 (40.0%), and non-iFOBT screening in 96/497 (19.3%). Overall, ADR (38.4% vs. 37.7%; p=0.43) and APC (0.66 vs. 0.66; p=0.97) were similar between CADe and CC. SSLPC was increased (0.30 vs. 0.19; p=0.049) in the CADe-arm vs. CC. Conclusions: In this study conducted by experienced endoscopists, CADe did not result in a statistically significant increase in ADR. However, the ADR of our control group substantially surpassed our sample size assumptions, increasing the risk of an underpowered trial. (Trialsearch.who.int:NL9135).

Published
2024

48. Unified Magnifying Endoscopic Classification (UMEC) of Gastrointestinal Lesions: A North American Validation Study.

Author

Fujiyoshi, Mary Raina Angeli, Fujiyoshi, Yusuke, Gimpaya, Nikko, Bechara, Robert, Jeyalingam, Thurarshen, Calo, Natalia Causada, Forbes, Nauzer, Pawlak, Katarzyna Monika, Khalaf, Kareem, Khan, Rishad, Atalla, Michael, Toshimori, Akiko, Shimamura, Yuto, Tanabe, Mayo, Teshima, Christopher, Mosko, Jeffrey D, May, Gary, Inoue, Haruhiro, and Grover, Samir C

Published
2024
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