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1,506 results on '"Foppiani A"'

1. Strain Optimization for ReBCO High-Temperature Superconducting Stellarator Coils in SIMSOPT

Author

Huslage, Paul, Paul, Elisabeth J., Gil, Mohammed Haque. Pedro F., Foppiani, Nicolo, Smoniewsk, Jason, and Stenson, Eve. V.

Subjects
Physics - Plasma Physics, Physics - Accelerator Physics, Physics - Applied Physics
Abstract

This work provides an optimization mechanism to ensure the compatibility of ReBCO (Rare-earth Barium Copper Oxide) high-temperature superconducting (HTS) tapes with non-planar stellarator coils. ReBCO coils enable higher field strengths and operating temperatures for the magnet systems of future fusion reactors but are sensitive to strain due to their brittle, ceramic functional layer. We have implemented a metric to optimize strain on stellarator coils made from ReBCO superconductors into the stellarator optimization framework \texttt{SIMSOPT} and used it to design new stellarator coil configurations. To ensure structural integrity of coils wound with HTS tape, we introduce a penalty on binormal curvature and torsion along a coil. It can be used to optimize the orientation of the winding path for a given coil filament or to jointly optimize orientation and coil filament. We apply the strain optimization to three cases. For the EPOS (Electrons and Positrons in an Optimized Stellarator) design, we combine the strain penalty with an objective for quasisymmetry into a single-stage optimization; this enables us to find a configuration with excellent quasisymmetry at the smallest possible size compatible with the use of ReBCO tape. For CSX (Columbia Stellarator eXperiment), in addition to HTS strain, we add a penalty to prevent net tape rotation to ease the coil winding process. If the strain is calculated for a coil at reactor scale, we find a considerable variation of the binormal and torsional strain over the cross section of the large winding pack (0.5\,m x 0.5\,m). By exploiting the overall orientation of the winding pack as a degree of freedom, we can reduce binormal and torsional strains below limits for every ReBCO stack., Comment: 14 pages, 14 figures

Published
2024

11. MORFEO enters final design phase

Author

Busoni, Lorenzo, Agapito, Guido, Ballone, Alessandro, Puglisi, Alfio, Goncharov, Alexander, Petrella, Amedeo, Di Cianno, Amico, Balestra, Andrea, Baruffolo, Andrea, Bianco, Andrea, Di Dato, Andrea, Valentini, Angelo, Di Francesco, Benedetta, Sassolas, Benoit, Salasnich, Bernardo, Arcidiacono, Carmelo, Plantet, Cedric, Eredia, Christian, Fantinel, Daniela, Selvestrel, Danilo, Malone, Deborah, Magrin, Demetrio, D'Auria, Domenico, Redaelli, Edoardo, Carolo, Elena, Costa, Elia, Portaluri, Elisa, Cascone, Enrico, Giro, Enrico, Battaini, Federico, Annibali, Francesca, Laudisio, Fulvio, Rodeghiero, Gabriele, Umbriaco, Gabriele, Chauvin, Gael, Di Rico, Gianluca, Pariani, Giorgio, Carlà, Giulia, Capasso, Giulio, Cosentino, Giuseppe, Correia, Jean Jacques, Foppiani, Italo, Di Antonio, Ivan, Farinato, Jacopo, Radhakrishnan, Kalyan Kumar, Gluck, Laurence, Pinard, Laurent, Marafatto, Luca, Scalera, Marcello Agostino, Gullieuszik, Marco, Bonaglia, Marco, Riva, Marco, Xompero, Marco, Bergomi, Maria, Aliverti, Matteo, Genoni, Matteo, Munari, Matteo, Dolci, Mauro, Christophe, Michel, Cantiello, Michele, Colapietro, Mirko, Devaney, Nicholas, Azzaroli, Nicolò, Grani, Paolo, Ciliegi, Paolo, Rabou, Patrick, Feautrier, Philippe, Schipani, Pietro, Ragazzoni, Roberto, Sordo, Rosanna, Briguglio, Runa, Lampitelli, Salvatore, Savarese, Salvatore, Benedetti, Simone, Di Filippo, Simone, Esposito, Simone, Chinellato, Simonetta, Oberti, Sylvain, Rochat, Sylvain, Lapucci, Tommaso, Di Giammatteo, Ugo, Cianniello, Vincenzo, De Caprio, Vincenzo, and Hubert, Zoltan

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

MORFEO (Multi-conjugate adaptive Optics Relay For ELT Observations, formerly MAORY), the MCAO system for the ELT, will provide diffraction-limited optical quality to the large field camera MICADO. MORFEO has officially passed the Preliminary Design Review and it is entering the final design phase. We present the current status of the project, with a focus on the adaptive optics system aspects and expected milestones during the next project phase.

Published
2023
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12. Zinc in Dermatology: Exploring Its Emerging Role in Enhancing Botulinum Toxin Formulations and Clinical Efficacy

Author

Lacey Foster, Jose A. Foppiani, Helen Xun, Daniela Lee, Begum Utz, Angelica Hernandez Alvarez, Maria J. Domingo-Escobar, Iulianna C. Taritsa, Dominika Gavlasova, Theodore C. Lee, Gavin J. Lin, Umar Choudry, and Samuel J. Lin

Subjects
zinc, botulinum toxin, dermatology, cosmetic science, aesthetic injectables, formulation stability, Biology (General), QH301-705.5
Abstract

This literature review provides a novel exploration of zinc’s multifaceted roles in dermatology, with a particular focus on its potential integration into botulinum toxin formulations—an area that remains relatively underexplored in clinical practice. Zinc is widely recognized for its critical functions in skin health, including morphogenesis, regeneration, and protection, and its use in aesthetic medicine offers a unique opportunity for innovation. Specifically, incorporating zinc into botulinum toxin formulations could enhance the efficacy and stability of these treatments. Although zinc has historically been used in topical dermatological products and systemic health interventions, its potential in cosmetic preparations, such as anti-aging therapies or non-invasive aesthetic treatments, remains under-researched. Emerging patents suggest promising formulations combining zinc with botulinum toxin that may improve product stability and extend therapeutic effects. While current studies on oral zinc supplementation present mixed results concerning its ability to prolong botulinum toxin effects, this underscores the need for more rigorous investigation in the realm of aesthetic medicine. Zinc’s well-established role in stabilizing dermatological products, such as sunscreens, and its applications in wound healing and skin regeneration, further highlights its potential for broader therapeutic uses beyond cosmetic applications. This review identifies a critical gap in the literature and calls for future research to optimize zinc concentrations and delivery methods specifically for aesthetic medical procedures, offering new insights into improving dermatological treatments beyond the scope of traditional cosmetic preparations.

Published
2024
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13. First application of a liquid argon time projection chamber for the search for intranuclear neutron-antineutron transitions and annihilation in $^{40}$Ar using the MicroBooNE detector

Author

MicroBooNE collaboration, Abratenko, P., Alterkait, O., Aldana, D. Andrade, Arellano, L., Asaadi, J., Ashkenazi, A., Balasubramanian, S., Baller, B., Barr, G., Barrow, D., Barrow, J., Basque, V., Rodrigues, O. Benevides, Berkman, S., Bhanderi, A., Bhat, A., Bhattacharya, M., Bishai, M., Blake, A., Bogart, B., Bolton, T., Book, J. Y., Camilleri, L., Cao, Y., Caratelli, D., Terrazas, I. Caro, Cavanna, F., Cerati, G., Chen, Y., Conrad, J. M., Convery, M., Cooper-Troendle, L., Crespo-Anadon, J. I., Cross, R., Del Tutto, M., Dennis, S. R., Detje, P., Devitt, A., Diurba, R., Djurcic, Z., Dorrill, R., Duffy, K., Dytman, S., Eberly, B., Englezos, P., Ereditato, A., Evans, J. J., Fine, R., Finnerud, O. G., Fleming, B. T., Foppiani, N., Foreman, W., Franco, D., Furmanski, A. P., Garcia-Gamez, D., Gardiner, S., Ge, G., Gollapinni, S., Goodwin, O., Gramellini, E., Green, P., Greenlee, H., Gu, W., Guenette, R., Guzowski, P., Hagaman, L., Hen, O., Hicks, R., Hilgenberg, C., Horton-Smith, G. A., Imani, Z., Irwin, B., Itay, R., James, C., Ji, X., Jiang, L., Jo, J. H., Johnson, R. A., Jwa, Y. J., Kalra, D., Kamp, N., Karagiorgi, G., Ketchum, W., Kirby, M., Kobilarcik, T., Kreslo, I., Lepetic, I., Li, J. -Y., Li, K., Li, Y., Lin, K., Littlejohn, B. R., Liu, H., Louis, W. C., Luo, X., Mariani, C., Marsden, D., Marshall, J., Martinez, N., Caicedo, D. A. Martinez, Martynenko, S., Mastbaum, A., McConkey, N., Meddage, V., Micallef, J., Miller, K., Mistry, K., Mohayai, T., Mogan, A., Mooney, M., Moor, A. F., Moore, C. D., Lepin, L. Mora, Moudgalya, M. M., Babu, S. Mulleria, Naples, D., Navrer-Agasson, A., Nayak, N., Nebot-Guinot, M., Nowak, J., Oza, N., Palamara, O., Pallat, N., Paolone, V., Papadopoulou, A., Papavassiliou, V., Parkinson, H., Pate, S. F., Patel, N., Pavlovic, Z., Piasetzky, E., Ponce-Pinto, I., Pophale, I., Qian, X., Raaf, J. L., Radeka, V., Rafique, A., Reggiani-Guzzo, M., Ren, L., Rochester, L., Rondon, J. Rodriguez, Rosenberg, M., Ross-Lonergan, M., von Rohr, C. Rudolph, Safa, I., Scanavini, G., Schmitz, D. W., Schukraft, A., Seligman, W., Shaevitz, M. H., Sharankova, R., Shi, J., Snider, E. L., Soderberg, M., Soldner-Rembold, S., Spitz, J., Stancari, M., John, J. St., Strauss, T., Szelc, A. M., Tang, W., Taniuchi, N., Terao, K., Thorpe, C., Torbunov, D., Totani, D., Toups, M., Tsai, Y. -T., Tyler, J., Uchida, M. A., Usher, T., Viren, B., Weber, M., Wei, H., White, A. J., Wolbers, S., Wongjirad, T., Wospakrik, M., Wresilo, K., Wright, N., Wu, W., Yandel, E., Yang, T., Yates, L. E., Yu, H. W., Zeller, G. P., Zennamo, J., and Zhang, C.

Subjects
High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract

We present a novel methodology to search for intranuclear neutron-antineutron transition ($n\rightarrow\bar{n}$) followed by $\bar{n}$-nucleon annihilation within an $^{40}$Ar nucleus, using the MicroBooNE liquid argon time projection chamber (LArTPC) detector. A discovery of $n\rightarrow\bar{n}$ transition or a new best limit on the lifetime of this process would either constitute physics beyond the Standard Model or greatly constrain theories of baryogenesis, respectively. The approach presented in this paper makes use of deep learning methods to select $n\rightarrow\bar{n}$ events based on their unique features and differentiate them from cosmogenic backgrounds. The achieved signal and background efficiencies are (70.22$\pm$6.04)\% and (0.0020$\pm$0.0003)\%, respectively. A demonstration of a search is performed with a data set corresponding to an exposure of $3.32 \times10^{26}\,$neutron-years, and where the background rate is constrained through direct measurement, assuming the presence of a negligible signal. With this approach, no excess of events over the background prediction is observed, setting a demonstrative lower bound on the $n\rightarrow\bar{n}$ lifetime in $^{40}$Ar of $\tau_{\textrm{m}} \gtrsim 1.1\times10^{26}\,$years, and on the free $n\rightarrow\bar{n}$ transition time of $\tau_{\textrm{\nnbar}} \gtrsim 2.6\times10^{5}\,$s, each at the $90\%$ confidence level. This analysis represents a first-ever proof-of-principle demonstration of the ability to search for this rare process in LArTPCs with high efficiency and low background., Comment: 22 pages, 7 figures, 6 tables

Published
2023

14. Measurement of three-dimensional inclusive muon-neutrino charged-current cross sections on argon with the MicroBooNE detector

Author

MicroBooNE Collaboration, Abratenko, P., Alterkait, O., Aldana, D. Andrade, Arellano, L., Asaadi, J., Ashkenazi, A., Balasubramanian, S., Baller, B., Barr, G., Barrow, D., Barrow, J., Basque, V., Rodrigues, O. Benevides, Berkman, S., Bhanderi, A., Bhat, A., Bhattacharya, M., Bishai, M., Blake, A., Bogart, B., Bolton, T., Book, J. Y., Camilleri, L., Cao, Y., Caratelli, D., Terrazas, I. Caro, Cavanna, F., Cerati, G., Chen, Y., Conrad, J. M., Convery, M., Cooper-Troendle, L., Crespo-Anadon, J. I., Del Tutto, M., Dennis, S. R., Detje, P., Devitt, A., Diurba, R., Djurcic, Z., Dorrill, R., Duffy, K., Dytman, S., Eberly, B., Englezos, P., Ereditato, A., Evans, J. J., Fine, R., Finnerud, O. G., Fleming, B. T., Foppiani, N., Foreman, W., Franco, D., Furmanski, A. P., Garcia-Gamez, D., Gardiner, S., Ge, G., Gollapinni, S., Goodwin, O., Gramellini, E., Green, P., Greenlee, H., Gu, W., Guenette, R., Guzowski, P., Hagaman, L., Hen, O., Hicks, R., Hilgenberg, C., Horton-Smith, G. A., Imani, Z., Irwin, B., Itay, R., James, C., Ji, X., Jiang, L., Jo, J. H., Johnson, R. A., Jwa, Y. J., Kalra, D., Kamp, N., Karagiorgi, G., Ketchum, W., Kirby, M., Kobilarcik, T., Kreslo, I., Leibovitch, M. B., Lepetic, I., Li, J. -Y., Li, K., Li, Y., Lin, K., Littlejohn, B. R., Liu, H., Louis, W. C., Luo, X., Mariani, C., Marsden, D., Marshall, J., Martinez, N., Caicedo, D. A. Martinez, Mastbaum, A., McConkey, N., Meddage, V., Micallef, J., Miller, K., Mistry, K., Mohayai, T., Mogan, A., Mooney, M., Moor, A. F., Moore, C. D., Lepin, L. Mora, Moudgalya, M., Babu, S. Mulleria, Naples, D., Navrer-Agasson, A., Nayak, N., Nebot-Guinot, M., Nowak, J., Oza, N., Palamara, O., Pallat, N., Paolone, V., Papadopoulou, A., Papavassiliou, V., Parkinson, H., Pate, S. F., Patel, N., Pavlovic, Z., Piasetzky, E., Ponce-Pinto, I., Pophale, I., Prince, S., Qian, X., Raaf, J. L., Radeka, V., Rafique, A., Reggiani-Guzzo, M., Ren, L., Rochester, L., Rondon, J. Rodriguez, Rosenberg, M., Ross-Lonergan, M., von Rohr, C. Rudolph, Safa, I., Scanavini, G., Schmitz, D. W., Schukraft, A., Seligman, W., Shaevitz, M. H., Sharankova, R., Shi, J., Snider, E. L., Soderberg, M., Soldner-Rembold, S., Spitz, J., Stancari, M., John, J. St., Strauss, T., Szelc, A. M., Tang, W., Taniuchi, N., Terao, K., Thorpe, C., Torbunov, D., Totani, D., Toups, M., Tsai, Y. -T., Tyler, J., Uchida, M. A., Usher, T., Viren, B., Weber, M., Wei, H., White, A. J., Williams, Z., Wolbers, S., Wongjirad, T., Wospakrik, M., Wresilo, K., Wright, N., Wu, W., Yandel, E., Yang, T., Yates, L. E., Yu, H. W., Zeller, G. P., Zennamo, J., and Zhang, C.

Subjects
High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

We report the measurement of the differential cross section $d^{2}\sigma (E_{\nu})/ d\cos(\theta_{\mu}) dP_{\mu}$ for inclusive muon-neutrino charged-current scattering on argon. This measurement utilizes data from 6.4$\times10^{20}$ protons on target of exposure collected using the MicroBooNE liquid argon time projection chamber located along the Fermilab Booster Neutrino Beam with a mean neutrino energy of approximately 0.8~GeV. The mapping from reconstructed kinematics to truth quantities, particularly from reconstructed to true neutrino energy, is validated within uncertainties by comparing the distribution of reconstructed hadronic energy in data to that of the model prediction in different muon scattering angle bins after applying a conditional constraint from the muon momentum distribution in data. The success of this validation gives confidence that the missing energy in the MicroBooNE detector is well-modeled within uncertainties in simulation, enabling the unfolding to a three-dimensional measurement over muon momentum, muon scattering angle, and neutrino energy. The unfolded measurement covers an extensive phase space, providing a wealth of information useful for future liquid argon time projection chamber experiments measuring neutrino oscillations. Comparisons against a number of commonly used model predictions are included and their performance in different parts of the available phase-space is discussed.

Published
2023

15. Measurement of ambient radon progeny decay rates and energy spectra in liquid argon using the MicroBooNE detector

Author

MicroBooNE collaboration, Abratenko, P., Alterkait, O., Aldana, D. Andrade, Arellano, L., Asaadi, J., Ashkenazi, A., Balasubramanian, S., Baller, B., Barr, G., Barrow, D., Barrow, J., Basque, V., Rodrigues, O. Benevides, Berkman, S., Bhanderi, A., Bhat, A., Bhattacharya, M., Bishai, M., Blake, A., Bogart, B., Bolton, T., Book, J. Y., Camilleri, L., Cao, Y., Caratelli, D., Terrazas, I. Caro, Cavanna, F., Cerati, G., Chen, Y., Conrad, J. M., Convery, M., Cooper-Troendle, L., Crespo-Anadon, J. I., Cross, R., Del Tutto, M., Dennis, S. R., Detje, P., Devitt, A., Diurba, R., Djurcic, Z., Dorrill, R., Duffy, K., Dytman, S., Eberly, B., Englezos, P., Ereditato, A., Evans, J. J., Fine, R., Finnerud, O. G., Fleming, B. T., Foppiani, N., Foreman, W., Franco, D., Furmanski, A. P., Garcia-Gamez, D., Gardiner, S., Ge, G., Gollapinni, S., Goodwin, O., Gramellini, E., Green, P., Greenlee, H., Gu, W., Guenette, R., Guzowski, P., Hagaman, L., Hen, O., Hicks, R., Hilgenberg, C., Horton-Smith, G. A., Imani, Z., Irwin, B., Itay, R., James, C., Ji, X., Jiang, L., Jo, J. H., Johnson, R. A., Jwa, Y. J., Kalra, D., Kamp, N., Karagiorgi, G., Ketchum, W., Kirby, M., Kobilarcik, T., Kreslo, I., Leibovitch, M. B., Lepetic, I., Li, J. -Y., Li, K., Li, Y., Lin, K., Littlejohn, B. R., Liu, H., Louis, W. C., Luo, X., Mariani, C., Marsden, D., Marshall, J., Martinez, N., Caicedo, D. A. Martinez, Martynenko, S., Mastbaum, A., McConkey, N., Meddage, V., Micallef, J., Miller, K., Mistry, K., Mohayai, T., Mogan, A., Mooney, M., Moor, A. F., Moore, C. D., Lepin, L. Mora, Moudgalya, M., Babu, S. Mulleria, Naples, D., Navrer-Agasson, A., Nayak, N., Nebot-Guinot, M., Nowak, J., Oza, N., Palamara, O., Pallat, N., Paolone, V., Papadopoulou, A., Papavassiliou, V., Parkinson, H., Pate, S. F., Patel, N., Pavlovic, Z., Piasetzky, E., Ponce-Pinto, I., Pophale, I., Qian, X., Raaf, J. L., Radeka, V., Rafique, A., Reggiani-Guzzo, M., Ren, L., Rochester, L., Rondon, J. Rodriguez, Rosenberg, M., Ross-Lonergan, M., von Rohr, C. Rudolph, Safa, I., Scanavini, G., Schmitz, D. W., Schukraft, A., Seligman, W., Shaevitz, M. H., Sharankova, R., Shi, J., Snider, E. L., Soderberg, M., Soldner-Rembold, S., Spitz, J., Stancari, M., John, J. St., Strauss, T., Szelc, A. M., Tang, W., Taniuchi, N., Terao, K., Thorpe, C., Torbunov, D., Totani, D., Toups, M., Tsai, Y. -T., Tyler, J., Uchida, M. A., Usher, T., Viren, B., Weber, M., Wei, H., White, A. J., Williams, Z., Wolbers, S., Wongjirad, T., Wospakrik, M., Wresilo, K., Wright, N., Wu, W., Yandel, E., Yang, T., Yates, L. E., Yu, H. W., Zeller, G. P., Zennamo, J., and Zhang, C.

Subjects
High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

We report measurements of radon progeny in liquid argon within the MicroBooNE time projection chamber (LArTPC). The presence of specific radon daughters in MicroBooNE's 85 metric tons of active liquid argon bulk is probed with newly developed charge-based low-energy reconstruction tools and analysis techniques to detect correlated $^{214}$Bi-$^{214}$Po radioactive decays. Special datasets taken during periods of active radon doping enable new demonstrations of the calorimetric capabilities of single-phase neutrino LArTPCs for $\beta$ and $\alpha$ particles with electron-equivalent energies ranging from 0.1 to 3.0 MeV. By applying $^{214}$Bi-$^{214}$Po detection algorithms to data recorded over a 46-day period, no statistically significant presence of radioactive $^{214}$Bi is detected, and a limit on the activity is placed at $<0.35$ mBq/kg at the 95% confidence level. This bulk $^{214}$Bi radiopurity limit -- the first ever reported for a liquid argon detector incorporating liquid-phase purification -- is then further discussed in relation to the targeted upper limit of 1 mBq/kg on bulk $^{222}$Rn activity for the DUNE neutrino detector.

Published
2023
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18. First measurement of $\eta$ production in neutrino interactions on argon with MicroBooNE

Author

MicroBooNE collaboration, Abratenko, P., Alterkait, O., Aldana, D. Andrade, Anthony, J., Arellano, L., Asaadi, J., Ashkenazi, A., Balasubramanian, S., Baller, B., Barr, G., Barrow, J., Basque, V., Rodrigues, O. Benevides, Berkman, S., Bhanderi, A., Bhat, A., Bhattacharya, M., Bishai, M., Blake, A., Bogart, B., Bolton, T., Book, J. Y., Camilleri, L., Cao, Y., Caratelli, D., Terrazas, I. Caro, Cavanna, F., Cerati, G., Chen, Y., Conrad, J. M., Convery, M., Cooper-Troendle, L., Crespo-Anadon, J. I., Del Tutto, M., Dennis, S. R., Detje, P., Devitt, A., Diurba, R., Djurcic, Z., Dorrill, R., Duffy, K., Dytman, S., Eberly, B., Englezos, P., Ereditato, A., Evans, J. J., Fine, R., Finnerud, O. G., Fleming, B. T., Foppiani, N., Foreman, W., Franco, D., Furmanski, A. P., Garcia-Gamez, D., Gardiner, S., Ge, G., Gollapinni, S., Goodwin, O., Gramellini, E., Green, P., Greenlee, H., Gu, W., Guenette, R., Guzowski, P., Hagaman, L., Hen, O., Hicks, R., Hilgenberg, C., Horton-Smith, G. A., Imani, Z., Irwin, B., Itay, R., James, C., Ji, X., Jiang, L., Jo, J. H., Johnson, R. A., Jwa, Y. J., Kalra, D., Kamp, N., Karagiorgi, G., Ketchum, W., Kirby, M., Kobilarcik, T., Kreslo, I., Leibovitch, M. B., Lepetic, I., Li, J. -Y., Li, K., Li, Y., Lin, K., Littlejohn, B. R., Louis, W. C., Luo, X., Mariani, C., Marsden, D., Marshall, J., Martinez, N., Caicedo, D. A. Martinez, Mason, K., Mastbaum, A., McConkey, N., Meddage, V., Miller, K., Mills, J., Mistry, K., Mohayai, T., Mogan, A., Mooney, M., Moor, A. F., Moore, C. D., Lepin, L. Mora, Babu, S. Mulleria, Naples, D., Navrer-Agasson, A., Nayak, N., Nebot-Guinot, M., Nowak, J., Oza, N., Palamara, O., Pallat, N., Paolone, V., Papadopoulou, A., Papavassiliou, V., Parkinson, H., Pate, S. F., Patel, N., Pavlovic, Z., Piasetzky, E., Ponce-Pinto, I., Pophale, I., Prince, S., Qian, X., Raaf, J. L., Radeka, V., Rafique, A., Reggiani-Guzzo, M., Ren, L., Rochester, L., Rondon, J. Rodriguez, Rosenberg, M., Ross-Lonergan, M., von Rohr, C. Rudolph, Scanavini, G., Schmitz, D. W., Schukraft, A., Seligman, W., Shaevitz, M. H., Sharankova, R., Shi, J., Snider, E. L., Soderberg, M., Soldner-Rembold, S., Spitz, J., Stancari, M., John, J. St., Strauss, T., Sword-Fehlberg, S., Szelc, A. M., Tang, W., Taniuchi, N., Terao, K., Thorpe, C., Torbunov, D., Totani, D., Toups, M., Tsai, Y. -T., Tyler, J., Uchida, M. A., Usher, T., Viren, B., Weber, M., Wei, H., White, A. J., Williams, Z., Wolbers, S., Wongjirad, T., Wospakrik, M., Wresilo, K., Wright, N., Wu, W., Yandel, E., Yang, T., Yates, L. E., Yu, H. W., Zeller, G. P., Zennamo, J., and Zhang, C.

Subjects
High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

We present a measurement of $\eta$ production from neutrino interactions on argon with the MicroBooNE detector. The modeling of resonant neutrino interactions on argon is a critical aspect of the neutrino oscillation physics program being carried out by the DUNE and Short Baseline Neutrino programs. $\eta$ production in neutrino interactions provides a powerful new probe of resonant interactions, complementary to pion channels, and is particularly suited to the study of higher-order resonances beyond the $\Delta(1232)$. We measure a flux-integrated cross section for neutrino-induced $\eta$ production on argon of $3.22 \pm 0.84 \; \textrm{(stat.)} \pm 0.86 \; \textrm{(syst.)}$ $10^{-41}{\textrm{cm}}^{2}$/nucleon. By demonstrating the successful reconstruction of the two photons resulting from $\eta$ production, this analysis enables a novel calibration technique for electromagnetic showers in GeV accelerator neutrino experiments.

Published
2023
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19. First demonstration of $\mathcal{O}(1\,\text{ns})$ timing resolution in the MicroBooNE liquid argon time projection chamber

Author

MicroBooNE collaboration, Abratenko, P., Alterkait, O., Aldana, D. Andrade, Anthony, J., Arellano, L., Asaadi, J., Ashkenazi, A., Balasubramanian, S., Baller, B., Barr, G., Barrow, J., Basque, V., Rodrigues, O. Benevides, Berkman, S., Bhanderi, A., Bhattacharya, M., Bishai, M., Blake, A., Bogart, B., Bolton, T., Book, J. Y., Camilleri, L., Cao, Y., Caratelli, D., Terrazas, I. Caro, Cavanna, F., Cerati, G., Chen, Y., Conrad, J. M., Convery, M., Cooper-Troendle, L., Crespo-Anadon, J. I., Del Tutto, M., Dennis, S. R., Detje, P., Devitt, A., Diurba, R., Djurcic, Z., Dorrill, R., Duffy, K., Dytman, S., Eberly, B., Ereditato, A., Evans, J. J., Fine, R., Finnerud, O. G., Fleming, B. T., Foppiani, N., Foreman, W., Franco, D., Furmanski, A. P., Garcia-Gamez, D., Gardiner, S., Ge, G., Gollapinni, S., Goodwin, O., Gramellini, E., Green, P., Greenlee, H., Gu, W., Guenette, R., Guzowski, P., Hagaman, L., Hen, O., Hicks, R., Hilgenberg, C., Horton-Smith, G. A., Imani, Z., Irwin, B., Itay, R., James, C., Ji, X., Jiang, L., Jo, J. H., Johnson, R. A., Jwa, Y. J., Kalra, D., Kamp, N., Karagiorgi, G., Ketchum, W., Kirby, M., Kobilarcik, T., Kreslo, I., Leibovitch, M. B., Lepetic, I., Li, J. -Y., Li, K., Li, Y., Lin, K., Littlejohn, B. R., Louis, W. C., Luo, X., Mariani, C., Marsden, D., Marshall, J., Martinez, N., Caicedo, D. A. Martinez, Mason, K., Mastbaum, A., McConkey, N., Meddage, V., Miller, K., Mills, J., Mistry, K., Mohayai, T., Mogan, A., Mooney, M., Moor, A. F., Moore, C. D., Lepin, L. Mora, Mousseau, J., Babu, S. Mulleria, Naples, D., Navrer-Agasson, A., Nayak, N., Nebot-Guinot, M., Nowak, J., Oza, N., Palamara, O., Pallat, N., Paolone, V., Papadopoulou, A., Papavassiliou, V., Parkinson, H., Pate, S. F., Patel, N., Pavlovic, Z., Piasetzky, E., Ponce-Pinto, I., Pophale, I., Prince, S., Qian, X., Raaf, J. L., Radeka, V., Rafique, A., Reggiani-Guzzo, M., Ren, L., Rochester, L., Rondon, J. Rodriguez, Rosenberg, M., Ross-Lonergan, M., von Rohr, C. Rudolph, Scanavini, G., Schmitz, D. W., Schukraft, A., Seligman, W., Shaevitz, M. H., Sharankova, R., Shi, J., Snider, E. L., Soderberg, M., Soldner-Rembold, S., Spitz, J., Stancari, M., John, J. St., Strauss, T., Sword-Fehlberg, S., Szelc, A. M., Tang, W., Taniuchi, N., Terao, K., Thorpe, C., Torbunov, D., Totani, D., Toups, M., Tsai, Y. -T., Tyler, J., Uchida, M. A., Usher, T., Viren, B., Weber, M., Wei, H., White, A. J., Williams, Z., Wolbers, S., Wongjirad, T., Wospakrik, M., Wresilo, K., Wright, N., Wu, W., Yandel, E., Yang, T., Yates, L. E., Yu, H. W., Zeller, G. P., Zennamo, J., and Zhang, C.

Subjects
High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

MicroBooNE is a neutrino experiment located in the Booster Neutrino Beamline (BNB) at Fermilab, which collected data from 2015 to 2021. MicroBooNE's liquid argon time projection chamber (LArTPC) is accompanied by a photon detection system consisting of 32 photomultiplier tubes used to measure the argon scintillation light and determine the timing of neutrino interactions. Analysis techniques combining light signals and reconstructed tracks are applied to achieve a neutrino interaction time resolution of $\mathcal{O}(1\,\text{ns})$. The result obtained allows MicroBooNE to access the ns neutrino pulse structure of the BNB for the first time. The timing resolution achieved will enable significant enhancement of cosmic background rejection for all neutrino analyses. Furthermore, the ns timing resolution opens new avenues to search for long-lived-particles such as heavy neutral leptons in MicroBooNE, as well as in future large LArTPC experiments, namely the SBN program and DUNE.

Published
2023

20. First measurement of quasi-elastic $\Lambda$ baryon production in muon anti-neutrino interactions in the MicroBooNE detector

Author

MicroBooNE collaboration, Abratenko, P., Aldana, D. Andrade, Anthony, J., Arellano, L., Asaadi, J., Ashkenazi, A., Balasubramanian, S., Baller, B., Barr, G., Barrow, J., Basque, V., Rodrigues, O. Benevides, Berkman, S., Bhanderi, A., Bhattacharya, M., Bishai, M., Blake, A., Bogart, B., Bolton, T., Book, J. Y., Camilleri, L., Caratelli, D., Terrazas, I. Caro, Cavanna, F., Cerati, G., Chen, Y., Conrad, J. M., Convery, M., Cooper-Troendle, L., Crespo-Anadon, J. I., Del Tutto, M., Dennis, S. R., Detje, P., Devitt, A., Diurba, R., Djurcic, Z., Dorrill, R., Duffy, K., Dytman, S., Eberly, B., Ereditato, A., Evans, J. J., Fine, R., Finnerud, O. G., Fleming, B. T., Foppiani, N., Foreman, W., Franco, D., Furmanski, A. P., Garcia-Gamez, D., Gardiner, S., Ge, G., Gollapinni, S., Goodwin, O., Gramellini, E., Green, P., Greenlee, H., Gu, W., Guenette, R., Guzowski, P., Hagaman, L., Hen, O., Hicks, R., Hilgenberg, C., Horton-Smith, G. A., Irwin, B., Itay, R., James, C., Ji, X., Jiang, L., Jo, J. H., Johnson, R. A., Jwa, Y. J., Kalra, D., Kamp, N., Karagiorgi, G., Ketchum, W., Kirby, M., Kobilarcik, T., Kreslo, I., Leibovitch, M. B., Lepetic, I., Li, J. -Y., Li, K., Li, Y., Lin, K., Littlejohn, B. R., Louis, W. C., Luo, X., Mariani, C., Marsden, D., Marshall, J., Martinez, N., Caicedo, D. A. Martinez, Mason, K., Mastbaum, A., McConkey, N., Meddage, V., Miller, K., Mills, J., Mistry, K., Mohayai, T., Mogan, A., Mooney, M., Moor, A. F., Moore, C. D., Lepin, L. Mora, Mousseau, J., Babu, S. Mulleria, Naples, D., Navrer-Agasson, A., Nayak, N., Nebot-Guinot, M., Nowak, J., Nunes, M., Oza, N., Palamara, O., Pallat, N., Paolone, V., Papadopoulou, A., Papavassiliou, V., Parkinson, H., Pate, S. F., Patel, N., Pavlovic, Z., Piasetzky, E., Ponce-Pinto, I., Pophale, I., Prince, S., Qian, X., Raaf, J. L., Radeka, V., Rafique, A., Reggiani-Guzzo, M., Ren, L., Rochester, L., Rondon, J. Rodriguez, Rosenberg, M., Ross-Lonergan, M., von Rohr, C. Rudolph, Scanavini, G., Schmitz, D. W., Schukraft, A., Seligman, W., Shaevitz, M. H., Sharankova, R., Shi, J., Snider, E. L., Soderberg, M., Soldner-Rembold, S., Spitz, J., Stancari, M., John, J. St., Strauss, T., Sword-Fehlberg, S., Szelc, A. M., Tang, W., Taniuchi, N., Terao, K., Thorpe, C., Torbunov, D., Totani, D., Toups, M., Tsai, Y. -T., Tyler, J., Uchida, M. A., Usher, T., Viren, B., Weber, M., Wei, H., White, A. J., Williams, Z., Wolbers, S., Wongjirad, T., Wospakrik, M., Wresilo, K., Wright, N., Wu, W., Yandel, E., Yang, T., Yates, L. E., Yu, H. W., Zeller, G. P., Zennamo, J., and Zhang, C.

Subjects
High Energy Physics - Experiment
Abstract

We present the first measurement of the cross section of Cabibbo-suppressed $\Lambda$ baryon production, using data collected with the MicroBooNE detector when exposed to the neutrinos from the Main Injector beam at the Fermi National Accelerator Laboratory. The data analyzed correspond to $2.2 \times 10^{20}$ protons on target of neutrino mode running and $4.9 \times 10^{20}$ protons on target of anti-neutrino mode running. An automated selection is combined with hand scanning, with the former identifying five candidate $\Lambda$ production events when the signal was unblinded, consistent with the GENIE prediction of $5.3 \pm 1.1$ events. Several scanners were employed, selecting between three and five events, compared with a prediction from a blinded Monte Carlo simulation study of $3.7 \pm 1.0$ events. Restricting the phase space to only include $\Lambda$ baryons that decay above MicroBooNE's detection thresholds, we obtain a flux averaged cross section of $2.0^{+2.2}_{-1.7} \times 10^{-40}$ cm$^2/$Ar, where statistical and systematic uncertainties are combined.

Published
2022

21. Science of Breast Implants

Author

Foppiani, Jose, Alvarez, Angelica Hernandez, Foster, Lacey, Clemens, Mark, Lin, Samuel J., Khajuria, Ankur, editor, Hong, Joon Pio, editor, Neligan, Peter, editor, and Rohrich, Rod J., Foreword by

Published
2024
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23. First Measurement of Differential Cross Sections for Muon Neutrino Charged Current Interactions on Argon with a Two-proton Final State in the MicroBooNE Detector

Author

MicroBooNE collaboration, Abratenko, P., Aldana, D. Andrade, Anthony, J., Arellano, L., Asaadi, J., Ashkenazi, A., Balasubramanian, S., Baller, B., Barr, G., Barrow, J., Basque, V., Bathe-Peters, L., Rodrigues, O. Benevides, Berkman, S., Bhanderi, A., Bhattacharya, M., Bishai, M., Blake, A., Bogart, B., Bolton, T., Book, J. Y., Camilleri, L., Caratelli, D., Terrazas, I. Caro, Cavanna, F., Cerati, G., Chen, Y., Conrad, J. M., Convery, M., Cooper-Troendle, L., Crespo-Anadon, J. I., Del Tutto, M., Dennis, S. R., Detje, P., Devitt, A., Diurba, R., Dorrill, R., Duffy, K., Dytman, S., Eberly, B., Ereditato, A., Evans, J. J., Fine, R., Finnerud, O. G., Fleming, B. T., Foppiani, N., Foreman, W., Franco, D., Furmanski, A. P., Garcia-Gamez, D., Gardiner, S., Ge, G., Gollapinni, S., Goodwin, O., Gramellini, E., Green, P., Greenlee, H., Gu, W., Guenette, R., Guzowski, P., Hagaman, L., Hen, O., Hicks, R., Hilgenberg, C., Horton-Smith, G. A., Irwin, B., Itay, R., James, C., Ji, X., Jiang, L., Jo, J. H., Johnson, R. A., Jwa, Y. J., Kalra, D., Kamp, N., Karagiorgi, G., Ketchum, W., Kirby, M., Kobilarcik, T., Kreslo, I., Leibovitch, M. B., Lepetic, I., Li, J. -Y., Li, K., Li, Y., Lin, K., Littlejohn, B. R., Louis, W. C., Luo, X., Manivannan, K., Mariani, C., Marsden, D., Marshall, J., Caicedo, D. A. Martinez, Mason, K., Mastbaum, A., McConkey, N., Meddage, V., Miller, K., Mills, J., Mistry, K., Mohayai, T., Mogan, A., Mooney, M., Moor, A. F., Moore, C. D., Lepin, L. Mora, Mousseau, J., Babu, S. Mulleria, Naples, D., Navrer-Agasson, A., Nayak, N., Nebot-Guinot, M., Nowak, J., Nunes, M., Oza, N., Palamara, O., Pallat, N., Paolone, V., Papadopoulou, A., Papavassiliou, V., Parkinson, H., Pate, S. F., Patel, N., Pavlovic, Z., Piasetzky, E., Ponce-Pinto, I., Pophale, I., Prince, S., Qian, X., Raaf, J. L., Radeka, V., Reggiani-Guzzo, M., Ren, L., Rochester, L., Rondon, J. Rodriguez, Rosenberg, M., Ross-Lonergan, M., von Rohr, C. Rudolph, Scanavini, G., Schmitz, D. W., Schukraft, A., Seligman, W., Shaevitz, M. H., Sharankova, R., Shi, J., Smith, A., Snider, E. L., Soderberg, M., Soldner-Rembold, S., Spitz, J., Stancari, M., John, J. St., Strauss, T., Sword-Fehlberg, S., Szelc, A. M., Tang, W., Taniuchi, N., Terao, K., Thorpe, C., Torbunov, D., Totani, D., Toups, M., Tsai, Y. -T., Tyler, J., Uchida, M. A., Usher, T., Viren, B., Weber, M., Wei, H., White, A. J., Williams, Z., Wolbers, S., Wongjirad, T., Wospakrik, M., Wresilo, K., Wright, N., Wu, W., Yandel, E., Yang, T., Yates, L. E., Yu, H. W., Zeller, G. P., Zennamo, J., and Zhang, C.

Subjects
High Energy Physics - Experiment, Nuclear Experiment
Abstract

We present the first measurement of differential cross sections for charged-current muon neutrino interactions on argon with one muon, two protons, and no pions in the final state. Such interactions leave the target nucleus in a two-particle two-hole state; these states are of great interest, but currently there is limited information about their production in neutrino-nucleus interactions. Detailed investigations of the production of two-particle two-hole states are vital to support upcoming experiments exploring the nature of the neutrino, and the development of the liquid-argon time-projection-chamber has made possible the isolation of such final states. The opening angle between the two protons, the angle between the total proton momentum and the muon, and the total transverse momentum of the final state system are sensitive to the underlying physics processes as embodied in a variety of models. Realistic initial-state momentum distributions are shown to be important in reproducing the data., Comment: Resubmitted to PRL in response to reviewer comments

Published
2022

24. First constraints on light sterile neutrino oscillations from combined appearance and disappearance searches with the MicroBooNE detector

Author

MicroBooNE collaboration, Abratenko, P., Aldana, D. Andrade, Anthony, J., Arellano, L., Asaadi, J., Ashkenazi, A., Balasubramanian, S., Baller, B., Barr, G., Barrow, J., Basque, V., Bathe-Peters, L., Rodrigues, O. Benevides, Berkman, S., Bhanderi, A., Bhattacharya, M., Bishai, M., Blake, A., Bogart, B., Bolton, T., Book, J. Y., Camilleri, L., Caratelli, D., Terrazas, I. Caro, Cavanna, F., Cerati, G., Chen, Y., Conrad, J. M., Convery, M., Cooper-Troendle, L., Crespo-Anadon, J. I., Del Tutto, M., Dennis, S. R., Detje, P., Devitt, A., Diurba, R., Dorrill, R., Duffy, K., Dytman, S., Eberly, B., Ereditato, A., Evans, J. J., Fine, R., Finnerud, O. G., Fleming, B. T., Foppiani, N., Foreman, W., Franco, D., Furmanski, A. P., Garcia-Gamez, D., Gardiner, S., Ge, G., Gollapinni, S., Goodwin, O., Gramellini, E., Green, P., Greenlee, H., Gu, W., Guenette, R., Guzowski, P., Hagaman, L., Hen, O., Hicks, R., Hilgenberg, C., Horton-Smith, G. A., Irwin, B., Itay, R., James, C., Ji, X., Jiang, L., Jo, J. H., Johnson, R. A., Jwa, Y. J., Kalra, D., Kamp, N., Karagiorgi, G., Ketchum, W., Kirby, M., Kobilarcik, T., Kreslo, I., Leibovitch, M. B., Lepetic, I., Li, J. -Y., Li, K., Li, Y., Lin, K., Littlejohn, B. R., Louis, W. C., Luo, X., Manivannan, K., Mariani, C., Marsden, D., Marshall, J., Martinez, N., Caicedo, D. A. Martinez, Mason, K., Mastbaum, A., McConkey, N., Meddage, V., Miller, K., Mills, J., Mistry, K., Mohayai, T., Mogan, A., Mooney, M., Moor, A. F., Moore, C. D., Lepin, L. Mora, Mousseau, J., Babu, S. Mulleria, Naples, D., Navrer-Agasson, A., Nayak, N., Nebot-Guinot, M., Nowak, J., Nunes, M., Oza, N., Palamara, O., Pallat, N., Paolone, V., Papadopoulou, A., Papavassiliou, V., Parkinson, H., Pate, S. F., Patel, N., Pavlovic, Z., Piasetzky, E., Ponce-Pinto, I., Pophale, I., Prince, S., Qian, X., Raaf, J. L., Radeka, V., Reggiani-Guzzo, M., Ren, L., Rochester, L., Rondon, J. Rodriguez, Rosenberg, M., Ross-Lonergan, M., von Rohr, C. Rudolph, Scanavini, G., Schmitz, D. W., Schukraft, A., Seligman, W., Shaevitz, M. H., Sharankova, R., Shi, J., Smith, A., Snider, E. L., Soderberg, M., Soldner-Rembold, S., Spitz, J., Stancari, M., John, J. St., Strauss, T., Sword-Fehlberg, S., Szelc, A. M., Tang, W., Taniuchi, N., Terao, K., Thorpe, C., Torbunov, D., Totani, D., Toups, M., Tsai, Y. -T., Tyler, J., Uchida, M. A., Usher, T., Viren, B., Weber, M., Wei, H., White, A. J., Williams, Z., Wolbers, S., Wongjirad, T., Wospakrik, M., Wresilo, K., Wright, N., Wu, W., Yandel, E., Yang, T., Yates, L. E., Yu, H. W., Zeller, G. P., Zennamo, J., and Zhang, C.

Subjects
High Energy Physics - Experiment
Abstract

We present a search for eV-scale sterile neutrino oscillations in the MicroBooNE liquid argon detector, simultaneously considering all possible appearance and disappearance effects within the $3+1$ active-to-sterile neutrino oscillation framework. We analyze the neutrino candidate events for the recent measurements of charged-current $\nu_e$ and $\nu_{\mu}$ interactions in the MicroBooNE detector, using data corresponding to an exposure of 6.37$\times$10$^{20}$ protons on target from the Fermilab booster neutrino beam. We observe no evidence of light sterile neutrino oscillations and derive exclusion contours at the $95\%$ confidence level in the plane of the mass-squared splitting $\Delta m^2_{41}$ and the sterile neutrino mixing angles $\theta_{\mu e}$ and $\theta_{ee}$, excluding part of the parameter space allowed by experimental anomalies. Cancellation of $\nu_e$ appearance and $\nu_e$ disappearance effects due to the full $3+1$ treatment of the analysis leads to a degeneracy when determining the oscillation parameters, which is discussed in this paper and will be addressed by future analyses., Comment: 9 pages, 4 figures; supplemental: 6 pages, 8 figures

Published
2022
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25. Testing Explanations of Short Baseline Neutrino Anomalies

Author

Foppiani, Nicolò

Subjects
High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract

The experimental observation of neutrino oscillations profoundly impacted the physics of neutrinos, from being well understood theoretically to requiring new physics beyond the standard model of particle physics. Indeed, the mystery of neutrino masses implies the presence of new particles never observed before, often called sterile neutrinos, as they would not undergo standard weak interactions. And while neutrino oscillation measurements entered the precision era, reaching percent-level precision, many experimental results show significant discrepancies with the standard model, at baselines much shorter than typical oscillation baselines, like LSND, MiniBooNE, gallium experiments, and reactor antineutrino measurements. These short baseline anomalies could be explained by the addition of a light sterile neutrino, with mass in the $1-10~\text{eV}$ range, however, in strong tension with many null experimental observations. Other explanations that rely on sterile neutrinos with masses in the $1-500~\text{MeV}$ could resolve the tension. Here we test both classes of models. On the one hand, we look for datasets collected at a short baseline which can constrain heavy sterile neutrino models. We find that the minimal model is fully constrained, but several extensions of this model could weaken the current constraint and be tested with current and future datasets. On the other hand, we test the presence of neutrino oscillations at short baselines, induced by a light sterile state, with the data collected by the MicroBooNE experiment, a liquid argon time projection chamber specifically designed to resolve the details of each neutrino interaction. We report null results from both analyses, further constraining the space of possible explanations for the short baseline anomalies. If new physics lies behind the short baseline anomaly puzzle, it is definitely not described by a simple model., Comment: PhD thesis

Published
2022

27. Practical implications of androgen receptor inhibitors for prostate cancer treatment

Author

Fabio Campodonico, Luca Foppiani, Vittoria Campodonico, and Carlo Introini

Subjects
androgen receptor inhibitors, antiandrogens, androgen deprivation therapy, prostate cancer, enzalutamide, apalutamide, darolutamide, Internal medicine, RC31-1245
Abstract

Antiandrogens have been used for the treatment of prostate cancer as a single agent or in combination with hormone deprivation therapy. New generation antiandrogens act like androgen receptor inhibitors (ARIs). Their binding complex blocks the pathways of cellular proliferation and differentiation of the prostate. Enzalutamide, apalutamide and darolutamide are the new ARIs that demonstrated acceptable tolerability and toxicity, both active in hormone-sensitive and castration-resistant prostate cancer (CRPC). There is no evidence of superiority of one drug over the other, therefore the therapeutic choice depends on the safety profile in relation to the individual patient, their comorbidities and clinical condition. ARIs have also shown promising results in association with new drugs that are active on patients with metastatic CRPC carrying the mutated breast cancer gene (BRCA). Before undergoing new antiandrogenic therapies, patients should be evaluated for cardiological and metabolic risk and possible drug interactions.

Published
2024
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28. Short-term effects of Mediterranean diet on nutritional status in adults affected by Osteogenesis Imperfecta: a pilot study

Author

Ramona De Amicis, Simona Bertoli, Amalia Bruno, Giulia De Carlo, Alberto Battezzati, Andrea Foppiani, Alessandro Leone, and Antonella Lo Mauro

Subjects
Osteogenesis Imperfecta, Mediterranean diet, Nutritional status, Body composition, Dietary treatment, Medicine
Abstract

Abstract Background Osteogenesis Imperfecta (OI) is a heterogeneous group of connective tissue disorders, characterized by varying degrees of skeletal fragility. Patients experience a range of comorbidities, such as obesity, cardiovascular, and gastrointestinal complications, especially in adulthood. All aspects that could benefit from dietary intervention. The aim of this study was to evaluate the effects of a 6-months restricted Mediterranean Diet (rMD) on nutritional status in adult patients affected by OI. We carried out a 6-months longitudinal pilot study. 14 adults (median age: 35 years; 7 women; 7 OI type III) where recruited in 2019 among the members of As.It.O.I., the Italian Association of Osteogenesis Imperfecta. As.It.O.I. All the evaluations were performed at the University of Milan, Italy. The rMD provided a reduction of 30% from daily total energy expenditure. 45% of calories derived from carbohydrates, 35% from fat and 0.7–1.0 g/kg of body weight from proteins. Comparisons of continuous variables after 6 months of intervention were performed by the paired t-test. All P-values were two-tailed, and p

Published
2024
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29. Differential cross section measurement of charged current $\nu_{e}$ interactions without final-state pions in MicroBooNE

Author

MicroBooNE collaboration, Abratenko, P., Anthony, J., Arellano, L., Asaadi, J., Ashkenazi, A., Balasubramanian, S., Baller, B., Barnes, C., Barr, G., Barrow, J., Basque, V., Bathe-Peters, L., Rodrigues, O. Benevides, Berkman, S., Bhanderi, A., Bhattacharya, M., Bishai, M., Blake, A., Bogart, B., Bolton, T., Book, J. Y., Camilleri, L., Caratelli, D., Terrazas, I. Caro, Cavanna, F., Cerati, G., Chen, Y., Conrad, J. M., Convery, M., Cooper-Troendle, L., Crespo-Anadon, J. I., Del Tutto, M., Dennis, S. R., Detje, P., Devitt, A., Diurba, R., Dorrill, R., Duffy, K., Dytman, S., Eberly, B., Ereditato, A., Evans, J. J., Fine, R., Finnerud, O. G., Fleming, B. T., Foppiani, N., Foreman, W., Franco, D., Furmanski, A. P., Garcia-Gamez, D., Gardiner, S., Ge, G., Gollapinni, S., Goodwin, O., Gramellini, E., Green, P., Greenlee, H., Gu, W., Guenette, R., Guzowski, P., Hagaman, L., Hen, O., Hicks, R., Hilgenberg, C., Horton-Smith, G. A., Irwin, B., Itay, R., James, C., Ji, X., Jiang, L., Jo, J. H., Johnson, R. A., Jwa, Y. J., Kalra, D., Kamp, N., Karagiorgi, G., Ketchum, W., Kirby, M., Kobilarcik, T., Kreslo, I., Leibovitch, M. B., Lepetic, I., Li, J. -Y., Li, K., Li, Y., Lin, K., Littlejohn, B. R., Louis, W. C., Luo, X., Manivannan, K., Mariani, C., Marsden, D., Marshall, J., Caicedo, D. A. Martinez, Mason, K., Mastbaum, A., McConkey, N., Meddage, V., Miller, K., Mills, J., Mistry, K., Mohayai, T., Mogan, A., Mooney, M., Moor, A. F., Moore, C. D., Lepin, L. Mora, Mousseau, J., Babu, S. Mulleria, Naples, D., Navrer-Agasson, A., Nayak, N., Nebot-Guinot, M., Newmark, D. A., Nowak, J., Nunes, M., Oza, N., Palamara, O., Pallat, N., Paolone, V., Papadopoulou, A., Papavassiliou, V., Parkinson, H., Pate, S. F., Patel, N., Pavlovic, Z., Piasetzky, E., Ponce-Pinto, I., Prince, S., Qian, X., Raaf, J. L., Radeka, V., Reggiani-Guzzo, M., Ren, L., Rochester, L., Rondon, J. Rodriguez, Rosenberg, M., Ross-Lonergan, M., von Rohr, C. Rudolph, Scanavini, G., Schmitz, D. W., Schukraft, A., Seligman, W., Shaevitz, M. H., Sharankova, R., Shi, J., Smith, A., Snider, E. L., Soderberg, M., Soldner-Rembold, S., Spitz, J., Stancari, M., John, J. St., Strauss, T., Sword-Fehlberg, S., Szelc, A. M., Tang, W., Taniuchi, N., Terao, K., Thorpe, C., Torbunov, D., Totani, D., Toups, M., Tsai, Y. -T., Tyler, J., Uchida, M. A., Usher, T., Viren, B., Weber, M., Wei, H., White, A. J., Williams, Z., Wolbers, S., Wongjirad, T., Wospakrik, M., Wresilo, K., Wright, N., Wu, W., Yandel, E., Yang, T., Yates, L. E., Yu, H. W., Zeller, G. P., Zennamo, J., and Zhang, C.

Subjects
High Energy Physics - Experiment
Abstract

In this letter we present the first measurements of an exclusive electron neutrino cross section with the MicroBooNE experiment using data from the Booster Neutrino Beamline at Fermilab. These measurements are made for a selection of charged-current electron neutrinos without final-state pions. Differential cross sections are extracted in energy and angle with respect to the beam for the electron and the leading proton. The differential cross section as a function of proton energy is measured using events with protons both above and below the visibility threshold. This is done by including a separate selection of electron neutrino events without reconstructed proton candidates in addition to those with proton candidates. Results are compared to the predictions from several modern generators, and we find the data agrees well with these models. The data shows best agreement, as quantified by $p$-value, with the generators that predict a lower overall cross section, such as GENIE v3 and NuWro.

Published
2022

30. Search for long-lived heavy neutral leptons and Higgs portal scalars decaying in the MicroBooNE detector

Author

MicroBooNE collaboration, Abratenko, P., Anthony, J., Arellano, L., Asaadi, J., Ashkenazi, A., Balasubramanian, S., Baller, B., Barnes, C., Barr, G., Barrow, J., Basque, V., Bathe-Peters, L., Rodrigues, O. Benevides, Berkman, S., Bhanderi, A., Bhattacharya, M., Bishai, M., Blake, A., Bogart, B., Bolton, T., Book, J. Y., Camilleri, L., Caratelli, D., Terrazas, I. Caro, Cavanna, F., Cerati, G., Chen, Y., Conrad, J. M., Convery, M., Cooper-Troendle, L., Crespo-Anadon, J. I., Del Tutto, M., Dennis, S. R., Detje, P., Devitt, A., Diurba, R., Dorrill, R., Duffy, K., Dytman, S., Eberly, B., Ereditato, A., Evans, J. J., Fine, R., Finnerud, O. G., Fleming, B. T., Foppiani, N., Foreman, W., Franco, D., Furmanski, A. P., Garcia-Gamez, D., Gardiner, S., Ge, G., Gollapinni, S., Goodwin, O., Gramellini, E., Green, P., Greenlee, H., Gu, W., Guenette, R., Guzowski, P., Hagaman, L., Hen, O., Hicks, R., Hilgenberg, C., Horton-Smith, G. A., Itay, R., James, C., Ji, X., Jiang, L., Jo, J. H., Johnson, R. A., Jwa, Y. J., Kalra, D., Kamp, N., Kaneshige, N., Karagiorgi, G., Ketchum, W., Kirby, M., Kobilarcik, T., Kreslo, I., Leibovitch, M. B., Lepetic, I., Li, J. -Y., Li, K., Li, Y., Lin, K., Littlejohn, B. R., Louis, W. C., Luo, X., Manivannan, K., Mariani, C., Marsden, D., Marshall, J., Caicedo, D. A. Martinez, Mason, K., Mastbaum, A., McConkey, N., Meddage, V., Miller, K., Mills, J., Mistry, K., Mohayai, T., Mogan, A., Mooney, M., Moor, A. F., Moore, C. D., Lepin, L. Mora, Mousseau, J., Babu, S. Mulleria, Naples, D., Navrer-Agasson, A., Nayak, N., Nebot-Guinot, M., Newmark, D. A., Nowak, J., Nunes, M., Oza, N., Palamara, O., Pallat, N., Paolone, V., Papadopoulou, A., Papavassiliou, V., Parkinson, H., Pate, S. F., Patel, N., Pavlovic, Z., Piasetzky, E., Ponce-Pinto, I., Prince, S., Qian, X., Raaf, J. L., Radeka, V., Rafique, A., Reggiani-Guzzo, M., Ren, L., Rice, L. C. J., Rochester, L., Rondon, J. Rodriguez, Rosenberg, M., Ross-Lonergan, M., von Rohr, C. Rudolph, Scanavini, G., Schmitz, D. W., Schukraft, A., Seligman, W., Shaevitz, M. H., Sharankova, R., Shi, J., Smith, A., Snider, E. L., Soderberg, M., Soldner-Rembold, S., Spitz, J., Stancari, M., John, J. St., Strauss, T., Sword-Fehlberg, S., Szelc, A. M., Tang, W., Taniuchi, N., Terao, K., Thorpe, C., Torbunov, D., Totani, D., Toups, M., Tsai, Y. -T., Tyler, J., Uchida, M. A., Usher, T., Viren, B., Weber, M., Wei, H., White, A. J., Williams, Z., Wolbers, S., Wongjirad, T., Wospakrik, M., Wresilo, K., Wright, N., Wu, W., Yandel, E., Yang, T., Yates, L. E., Yu, H. W., Zeller, G. P., Zennamo, J., and Zhang, C.

Subjects
High Energy Physics - Experiment
Abstract

We present a search for long-lived Higgs portal scalars (HPS) and heavy neutral leptons (HNL) decaying in the MicroBooNE liquid-argon time projection chamber. The measurement is performed using data collected synchronously with the NuMI neutrino beam from Fermilab's Main Injector with a total exposure corresponding to $7.01 \times 10^{20}$ protons on target. We set upper limits at the $90\%$ confidence level on the mixing parameter $\lvert U_{\mu 4}\rvert^2$ ranging from $\lvert U_{\mu 4}\rvert^2<12.9\times 10^{-8}$ for Majorana HNLs with a mass of $m_{\rm HNL}=246$ MeV to $\lvert U_{\mu 4}\rvert^2<0.92 \times 10^{-8}$ for $m_{\rm HNL}=385$ MeV, assuming $\lvert U_{e 4}\rvert^2 = \lvert U_{\tau 4}\rvert^2 = 0$ and HNL decays into $\mu^\pm\pi^\mp$ pairs. These limits on $\lvert U_{\mu 4}\rvert^2$ represent an order of magnitude improvement in sensitivity compared to the previous MicroBooNE result. We also constrain the scalar-Higgs mixing angle $\theta$ by searching for HPS decays into $\mu^+\mu^-$ final states, excluding a contour in the parameter space with lower bounds of $\theta^2<31.3 \times 10^{-9}$ for $m_{\rm HPS}=212$ GeV and $\theta^2<1.09 \times 10^{-9}$ for $m_{\rm HPS}=275$ GeV. These are the first constraints on the scalar-Higgs mixing angle $\theta$ from a dedicated experimental search in this mass range., Comment: This paper is dedicated to the memory of Salvatore Davide Porzio. This is the journal accepted version with only minor presentational changes compared to preprint

Published
2022
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32. Dorsal Preservation versus Component Dorsal Hump Reduction Rhinoplasty: An Assessment of Patient-reported Outcomes

Author

Jose A. Foppiani, MD, Ngamthoiba Joy, MBBS, Angelica Hernandez Alvarez, MD, Maria J. Escobar-Domingo, MD, Daniela Lee, BS, Iulianna C. Taritsa, BA, Kirsten A. Schuster, MD, JD, Nancy Maty Aneken, MD, Bernard T. Lee, MD, MPH, MBA, and Samuel J. Lin, MD, MBA

Subjects
Surgery, RD1-811
Abstract

Background:. The literature on patient-reported outcomes (PROs) discussing dorsal preservation rhinoplasty (DPR) and component dorsal hump reduction (CDHR) is scarce. This study aims to fill the gap in PROs between these techniques. Methods:. A systematic review was conducted to investigate PROs of DPR and CDHR. A proportion meta-analysis was conducted using Stata statistical software. Results:. A total of 25 studies met our inclusion criteria, pooling 1706 participants, with 13 studies on CDHP and 12 studies on DPR. Overall satisfaction rates were high, varying from 84% to 100% across studies. A subgroup analysis revealed that both techniques exhibited equally high satisfaction with no statistical differences (P = 0.18). A random-effects model revealed that about two of 100 treated patients underwent revisions across our cohort (95% interquartile range: 0–4). Notably, the CDHR technique was associated with a significant 53.7-point reduction in the Standardized Cosmesis and Health Nasal Outcomes Survey (SCHNOS)-cosmetic domain [95% confidence interval (CI): −62.7 to −44.8, P < 0.001], along with a meaningful improvement in SCHNOS-obstructive scores by −27.3 points (95% CI: −50.5 to −4.04, P = 0.02). Conversely, the DPR was linked to a 55.3-point reduction in the SCHNOS-cosmetic domain (95% CI: −60.7 to −49.9, P < 0.001), and a −19.5 point change in the SCHNOS-obstructive domain (95% CI: −27.9 to −11.1, P < 0.001). Conclusion:. Although PROs are comparable, the literature suggests that CDHR outcomes may be better than DPR in alleviating obstructive symptoms, potentially offering an evidence-based choice for addressing functional concerns in rhinoplasty.

Published
2024
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34. Comparing Collagenase and Tissue Subcision for Cellulite Treatment of the Buttock and Thigh Regions: A Systematic Review and Meta-analysis

Author

Jose A. Foppiani, MD, Otakar Raska, MUDr, PhD, Cécilia Galinaud, Stephen Stearns, BS, Angelica Hernandez Alvarez, MD, Iulianna C. Taritsa, BA, Kirsten A. Schuster, MD, JD, Olivia A. Ho, MD, MMSc, MPH, Sarvam TerKonda, MD, Bernard T. Lee, MD, MBA, MPH, and Samuel J. Lin, MD, MBA

Subjects
Surgery, RD1-811
Abstract

Background:. In this systematic review, we assessed the therapeutic efficacy and safety of Clostridium histolyticum collagenase (CCH) and tissue subcision (TS) for treating cellulite, which ranges from subtle to pronounced lesions. Methods:. A systematic review was performed following PRISMA guidelines for CCH and TS treatment to the thigh and gluteal regions. A proportion meta-analysis was then conducted using Stata statistical software. Results:. A total of 14 studies were incorporated into the final analysis. Nine focused on TS and five on CCH injection, collectively reporting outcomes for 1254 patients. Of these, 465 received CCH injection and 789 underwent subcision. For bruising, rates were 89% [95% confidence interval (CI), 71%–96%] with CCH injection and 99% (95% CI, 85%–99%) for subcision; pain requiring analgesic was reported at 74% (95% CI, 55%–87%) for CCH and 60% (95% CI, 43%–76%) for subcision; both showed induration at 7% (95% CI, 5%–11% for CCH, 95% CI, 2%–25% for subcision), whereas skin discoloration was higher post-CCH injection at 16% (95% CI, 10%–26%) compared with 7% (95% CI, 5%–10%) postsubcision. Conclusions:. Both CCH and TS seem effective treatments for cellulite. However, upon evaluating the adverse outcomes between the two modalities, subcision demonstrated a higher incidence of bruising, albeit similar rates of induration compared with CCH injection. Conversely, the CCH injection group manifested a higher propensity for pain requiring analgesia and notably exhibited increased instances of skin discoloration compared with their subcision patient group. Further standardized research is crucial for more informed cellulite treatment decisions and for comparing efficacy, safety, and cost-effectiveness between TS and CCH.

Published
2024
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35. Efficiently Exploring Multi-Dimensional Parameter Spaces Beyond the Standard Model

Author

Argüelles, Carlos A., Foppiani, Nicolò, and Hostert, Matheus

Subjects
High Energy Physics - Phenomenology, High Energy Physics - Experiment
Abstract

We propose a method to ease the challenges of exploring multi-dimensional parameter spaces in beyond-the-Standard Model theories. We evaluate the model likelihood for any choice of parameters by sampling the theory parameters intelligently and building a Kernel Density Estimator. By reducing the number of expensive Monte-Carlo simulations, this method provides a more efficient way to test complex theories. We illustrate our technique to set new limits on a short-lived heavy neutrino $N$, proposed as an explanation of anomalies in neutrino experiments. Using a search for lepton pairs in the T2K near detector, we find exclusion limits on the model parameters in a vast region of parameter space, fully exploiting the advantages of our new method. With a single Monte Carlo simulation, we obtain the differential event rate for arbitrary choices of model parameters, allowing us to cast limits on any slice of the model parameter space. We conclude that $N$ particles with lifetimes greater than $c \tau^0 \gtrsim 3~$cm are excluded by T2K data. We also derive model-independent constraints in terms of the total rate, lifetime, and $N$ mass and provide an approximated analytical formula. This method can be applied in other branches of physics to explore the landscape of theory parameters efficiently., Comment: 19 pages, 15 figures

Published
2022
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36. Measurement of neutral current single $\pi^0$ production on argon with the MicroBooNE detector

Author

MicroBooNE collaboration, Abratenko, P., Anthony, J., Arellano, L., Asaadi, J., Ashkenazi, A., Balasubramanian, S., Baller, B., Barnes, C., Barr, G., Barrow, J., Basque, V., Bathe-Peters, L., Rodrigues, O. Benevides, Berkman, S., Bhanderi, A., Bhat, A., Bhattacharya, M., Bishai, M., Blake, A., Bolton, T., Book, J. Y., Camilleri, L., Caratelli, D., Terrazas, I. Caro, Cavanna, F., Cerati, G., Chen, Y., Cianci, D., Conrad, J. M., Convery, M., Cooper-Troendle, L., Crespo-Anadon, J. I., Del Tutto, M., Dennis, S. R., Detje, P., Devitt, A., Diurba, R., Dorrill, R., Duffy, K., Dytman, S., Eberly, B., Ereditato, A., Evans, J. J., Fine, R., Finnerud, O. G., Aguirre, G. A. Fiorentini, Fitzpatrick, R. S., Fleming, B. T., Foppiani, N., Franco, D., Furmanski, A. P., Garcia-Gamez, D., Gardiner, S., Ge, G., Gollapinni, S., Goodwin, O., Gramellini, E., Green, P., Greenlee, H., Gu, W., Guenette, R., Guzowski, P., Hagaman, L., Hen, O., Hicks, R., Hilgenberg, C., Horton-Smith, G. A., Itay, R., James, C., Ji, X., Jiang, L., Jo, J. H., Johnson, R. A., Jwa, Y. J., Kalra, D., Kamp, N., Kaneshige, N., Karagiorgi, G., Ketchum, W., Kirby, M., Kobilarcik, T., Kreslo, I., Leibovitch, M. B., Lepetic, I., Li, J. -Y., Li, K., Li, Y., Lin, K., Littlejohn, B. R., Louis, W. C., Luo, X., Manivannan, K., Mariani, C., Marsden, D., Marshall, J., Caicedo, D. A. Martinez, Mason, K., Mastbaum, A., McConkey, N., Meddage, V., Mettler, T., Miller, K., Mills, J., Mistry, K., Mohayai, T., Mogan, A., Mooney, M., Moor, A. F., Moore, C. D., Lepin, L. Mora, Mousseau, J., Babu, S. Mulleria, Naples, D., Navrer-Agasson, A., Nayak, N., Nebot-Guinot, M., Neely, R. K., Newmark, D. A., Nowak, J., Nunes, M., Oza, N., Palamara, O., Paolone, V., Papadopoulou, A., Papavassiliou, V., Parkinson, H., Pate, S. F., Patel, N., Paudel, A., Pavlovic, Z., Piasetzky, E., Ponce-Pinto, I., Prince, S., Qian, X., Raaf, J. L., Radeka, V., Rafique, A., Reggiani-Guzzo, M., Ren, L., Rice, L. C. J., Rochester, L., Rondon, J. Rodriguez, Rosenberg, M., Ross-Lonergan, M., von Rohr, C. Rudolph, Scanavini, G., Schmitz, D. W., Schukraft, A., Seligman, W., Shaevitz, M. H., Sharankova, R., Shi, J., Sinclair, J., Smith, A., Snider, E. L., Soderberg, M., Soldner-Rembold, S., Spentzouris, P., Spitz, J., Stancari, M., John, J. St., Strauss, T., Sutton, K., Sword-Fehlberg, S., Szelc, A. M., Tang, W., Taniuchi, N., Terao, K., Thorpe, C., Torbunov, D., Totani, D., Toups, M., Tsai, Y. -T., Uchida, M. A., Usher, T., Viren, B., Weber, M., Wei, H., White, A. J., Williams, Z., Wolbers, S., Wongjirad, T., Wospakrik, M., Wresilo, K., Wright, N., Wu, W., Yandel, E., Yang, T., Yarbrough, G., Yates, L. E., Yu, H. W., Zeller, G. P., Zennamo, J., and Zhang, C.

Subjects
High Energy Physics - Experiment
Abstract

We report the first measurement of $\pi^0$ production in neutral current (NC) interactions on argon with average neutrino energy of $\lesssim1$~GeV. We use data from the MicroBooNE detector's 85-tonne active volume liquid argon time projection chamber situated in Fermilab's Booster Neutrino Beam and exposed to $5.89\times10^{20}$ protons on target for this measurement. Measurements of NC $\pi^0$ events are reported for two exclusive event topologies without charged pions. Those include a topology with two photons from the decay of the $\pi^0$ and one proton and a topology with two photons and zero protons. Flux-averaged cross-sections for each exclusive topology and for their semi-inclusive combination are extracted (efficiency-correcting for two-plus proton final states), and the results are compared to predictions from the \textsc{genie}, \textsc{neut}, and \textsc{NuWro} neutrino event generators. We measure cross sections of $1.243\pm0.185$ (syst) $\pm0.076$ (stat), $0.444\pm0.098\pm0.047$, and $0.624\pm0.131\pm0.075$ $[10^{-38}\textrm{cm}^2/\textrm{Ar}]$ for the semi-inclusive NC$\pi^0$, exclusive NC$\pi^0$+1p, and exclusive NC$\pi^0$+0p processes, respectively., Comment: 16 pages, 14 figures, 2 tables

Published
2022

37. Observation of Radon Mitigation in MicroBooNE by a Liquid Argon Filtration System

Author

MicroBooNE collaboration, Abratenko, P., Anthony, J., Arellano, L., Asaadi, J., Ashkenazi, A., Balasubramanian, S., Baller, B., Barnes, C., Barr, G., Barrow, J., Basque, V., Bathe-Peters, L., Rodrigues, O. Benevides, Berkman, S., Bhanderi, A., Bhat, A., Bhattacharya, M., Bishai, M., Blake, A., Bolton, T., Book, J. Y., Camilleri, L., Caratelli, D., Terrazas, I. Caro, Cavanna, F., Cerati, G., Chen, Y., Cianci, D., Conrad, J. M., Convery, M., Cooper-Troendle, L., Crespo-Anadon, J. I., Del Tutto, M., Dennis, S. R., Detje, P., Devitt, A., Diurba, R., Dorrill, R., Duffy, K., Dytman, S., Eberly, B., Ereditato, A., Evans, J. J., Fine, R., Aguirre, G. A. Fiorentini, Fitzpatrick, R. S., Fleming, B. T., Foppiani, N., Franco, D., Furmanski, A. P., Garcia-Gamez, D., Gardiner, S., Ge, G., Gollapinni, S., Goodwin, O., Gramellini, E., Green, P., Greenlee, H., Gu, W., Guenette, R., Guzowski, P., Hagaman, L., Hen, O., Hilgenberg, C., Horton-Smith, G. A., Hourlier, A., Itay, R., James, C., Ji, X., Jiang, L., Jo, J. H., Joe, C., Johnson, R. A., Jwa, Y. J., Kalra, D., Kamp, N., Kaneshige, N., Karagiorgi, G., Ketchum, W., Kirby, M., Kobilarcik, T., Kreslo, I., Lepetic, I., Li, J. -Y., Li, K., Li, Y., Lin, K., Littlejohn, B. R., Louis, W. C., Luo, X., Manivannan, K., Mariani, C., Marsden, D., Marshall, J., Caicedo, D. A. Martinez, Mason, K., Mastbaum, A., McConkey, N., Meddage, V., Mettler, T., Miller, K., Mills, J., Mistry, K., Mohayai, T., Mogan, A., Mooney, M., Moor, A. F., Moore, C. D., Lepin, L. Mora, Mousseau, J., Babu, S. Mulleria, Naples, D., Navrer-Agasson, A., Nayak, N., Nebot-Guinot, M., Neely, R. K., Newmark, D. A., Nowak, J., Nunes, M., Palamara, O., Paolone, V., Papadopoulou, A., Papavassiliou, V., Parkinson, H. B., Pate, S. F., Patel, N., Paudel, A., Pavlovic, Z., Piasetzky, E., Ponce-Pinto, I., Prince, S., Qian, X., Raaf, J. L., Radeka, V., Rafique, A., Reggiani-Guzzo, M., Ren, L., Rice, L. C. J., Rochester, L., Rondon, J. Rodriguez, Rosenberg, M., Ross-Lonergan, M., von Rohr, C. Rudolph, Scanavini, G., Schmitz, D. W., Schukraft, A., Seligman, W., Shaevitz, M. H., Sharankova, R., Shi, J., Sinclair, J., Smith, A., Snider, E. L., Soderberg, M., Soldner-Rembold, S., Spentzouris, P., Spitz, J., Stancari, M., John, J. St., Strauss, T., Sutton, K., Sword-Fehlberg, S., Szelc, A. M., Tang, W., Terao, K., Thorpe, C., Torbunov, D., Totani, D., Toups, M., Tsai, Y. -T., Uchida, M. A., Usher, T., Viren, B., Weber, M., Wei, H., White, A. J., Williams, Z., Wolbers, S., Wongjirad, T., Wospakrik, M., Wresilo, K., Wright, N., Wu, W., Yandel, E., Yang, T., Yarbrough, G., Yates, L. E., Yu, H. W., Zeller, G. P., Zennamo, J., Zhang, C., and Zuckerbrot, M.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

The MicroBooNE liquid argon time projection chamber (LArTPC) maintains a high level of liquid argon purity through the use of a filtration system that removes electronegative contaminants in continuously-circulated liquid, recondensed boil off, and externally supplied argon gas. We use the MicroBooNE LArTPC to reconstruct MeV-scale radiological decays. Using this technique we measure the liquid argon filtration system's efficacy at removing radon. This is studied by placing a 500 kBq $^{222}$Rn source upstream of the filters and searching for a time-dependent increase in the number of radiological decays in the LArTPC. In the context of two models for radon mitigation via a liquid argon filtration system, a slowing mechanism and a trapping mechanism, MicroBooNE data supports a radon reduction factor of greater than 99.999% or 97%, respectively. Furthermore, a radiological survey of the filters found that the copper-based filter material was the primary medium that removed the $^{222}$Rn. This is the first observation of radon mitigation in liquid argon with a large-scale copper-based filter and could offer a radon mitigation solution for future large LArTPCs., Comment: 14 pages, 7 figures, accepted by the Journal of Instrumentation

Published
2022
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38. White Paper on Light Sterile Neutrino Searches and Related Phenomenology

Author

Acero, M. A., Argüelles, C. A., Hostert, M., Kalra, D., Karagiorgi, G., Kelly, K. J., Littlejohn, B., Machado, P., Pettus, W., Toups, M., Ross-Lonergan, M., Sousa, A., Surukuchi, P. T., Wong, Y. Y. Y., Abdallah, W., Abdullahi, A. M., Akutsu, R., Alvarez-Ruso, L., Alves, D. S. M., Aurisano, A., Balantekin, A. B., Berryman, J. M., Bertólez-Martínez, T., Brunner, J., Blennow, M., Bolognesi, S., Borusinski, M., Cianci, D., Collin, G., Conrad, J. M., Crow, B., Denton, P. B., Duvall, M., Fernández-Martinez, E., Fong, C. S., Foppiani, N., Forero, D. V., Friend, M., García-Soto, A., Giganti, C., Giunti, C., Gandhi, R., Ghosh, M., Hardin, J., Heeger, K. M., Ishitsuka, M., Izmaylov, A., Jones, B. J. P., Jordan, J. R., Kamp, N. W., Katori, T., Kim, S. B., Koerner, L. W., Lamoureux, M., Lasserre, T., Leach, K. G., Learned, J., Li, Y. F., Link, J. M., Louis, W. C., Mahn, K., Meyers, P. D., Maricic, J., Marko, D., Maruyama, T., Mertens, S., Minakata, H., Mocioiu, I., Mooney, M., Moulai, M. H., Nunokawa, H., Ochoa-Ricoux, J. P., Oh, Y. M., Ohlsson, T., Päs, H., Pershey, D., Robertson, R. G. H., Rosauro-Alcaraz, S., Rott, C., Roy, S., Salvado, J., Scott, M., Seo, S. H., Shaevitz, M. H., Smiley, M., Spitz, J., Stachurska, J., Thakore, T., Ternes, C. A., Thompson, A., Tseng, S., Vogelaar, B., Weiss, T., Wendell, R. A., Wright, T., Xin, Z., Yang, B. S., Yoo, J., Zennamo, J., Zettlemoyer, J., Zornoza, J. D., Ahmad, S., Basto-Gonzalez, V. S., Bowden, N. S., Cañas, B. C., Caratelli, D., Chang, C. V., Chen, C., Classen, T., Convery, M., Davies, G. S., Dennis, S. R., Djurcic, Z., Dorrill, R., Du, Y., Evans, J. J., Fahrendholz, U., Formaggio, J. A., Foust, B. T., Gatti, H. Frandini, Garcia-Gamez, D., Gariazzo, S., Gehrlein, J., Grant, C., Gomes, R. A., Hansell, A. B., Halzen, F., Ho, S., Zink, J. Hoefken, Jones, R. S., Kunkle, P., Li, J. -Y., Li, S. C., Luo, X., Malyshkin, Yu., Massaro, D., Mastbaum, A., Mohanta, R., Mumm, H. P., Nebot-Guinot, M., Neilson, R., Ni, K., Nieves, J., Gann, G. D. Orebi, Pandey, V., Pascoli, S., Qian, X., Rajaoalisoa, M., Roca, C., Roskovec, B., Saul-Sala, E., Saldaña, L., Scholberg, K., Shakya, B., Slocum, P. L., Snider, E. L., Steiger, H. Th. J., Steklain, A. F., Stock, M. R., Sutanto, F., Takhistov, V., Tsai, Y. -D., Tsai, Y. -T., Venegas-Vargas, D., Wallbank, M., Wang, E., Weatherly, P., Westerdale, S., Worcester, E., Wu, W., Yang, G., and Zamorano, B.

Subjects
High Energy Physics - Experiment, Astrophysics - Cosmology and Nongalactic Astrophysics, High Energy Physics - Phenomenology, Physics - Instrumentation and Detectors
Abstract

This white paper provides a comprehensive review of our present understanding of experimental neutrino anomalies that remain unresolved, charting the progress achieved over the last decade at the experimental and phenomenological level, and sets the stage for future programmatic prospects in addressing those anomalies. It is purposed to serve as a guiding and motivational "encyclopedic" reference, with emphasis on needs and options for future exploration that may lead to the ultimate resolution of the anomalies. We see the main experimental, analysis, and theory-driven thrusts that will be essential to achieving this goal being: 1) Cover all anomaly sectors -- given the unresolved nature of all four canonical anomalies, it is imperative to support all pillars of a diverse experimental portfolio, source, reactor, decay-at-rest, decay-in-flight, and other methods/sources, to provide complementary probes of and increased precision for new physics explanations; 2) Pursue diverse signatures -- it is imperative that experiments make design and analysis choices that maximize sensitivity to as broad an array of these potential new physics signatures as possible; 3) Deepen theoretical engagement -- priority in the theory community should be placed on development of standard and beyond standard models relevant to all four short-baseline anomalies and the development of tools for efficient tests of these models with existing and future experimental datasets; 4) Openly share data -- Fluid communication between the experimental and theory communities will be required, which implies that both experimental data releases and theoretical calculations should be publicly available; and 5) Apply robust analysis techniques -- Appropriate statistical treatment is crucial to assess the compatibility of data sets within the context of any given model., Comment: Contribution to Snowmass 2021 by the NF02 Topical Group (Understanding Experimental Neutrino Anomalies). Published in J. Phys. G as a Major Report

Published
2022
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43. Cosmic ray muon clustering for the MicroBooNE liquid argon time projection chamber using sMask-RCNN

Author

MicroBooNE collaboration, Abratenko, P., An, R., Anthony, J., Arellano, L., Asaadi, J., Ashkenazi, A., Balasubramanian, S., Baller, B., Barnes, C., Barr, G., Barrow, J., Basque, V., Bathe-Peters, L., Rodrigues, O. Benevides, Berkman, S., Bhanderi, A., Bhat, A., Bishai, M., Blake, A., Bolton, T., Book, J. Y., Camilleri, L., Caratelli, D., Terrazas, I. Caro, Cavanna, F., Cerati, G., Chen, Y., Church, E., Cianci, D., Conrad, J. M., Convery, M., Cooper-Troendle, L., Crespo-Anadon, J. I., Del Tutto, M., Dennis, S. R., Detje, P., Devitt, A., Diurba, R., Dorrill, R., Duffy, K., Dytman, S., Eberly, B., Ereditato, A., Evans, J. J., Fine, R., Aguirre, G. A. Fiorentini, Fitzpatrick, R. S., Fleming, B. T., Foppiani, N., Franco, D., Furmanski, A. P., Garcia-Gamez, D., Gardiner, S., Ge, G., Gollapinni, S., Goodwin, O., Gramellini, E., Green, P., Greenlee, H., Gu, W., Guenette, R., Guzowski, P., Hagaman, L., Hen, O., Hilgenberg, C., Horton-Smith, G. A., Hourlier, A., Itay, R., James, C., Ji, X., Jiang, L., Jo, J. H., Johnson, R. A., Jwa, Y. J., Kalra, D., Kamp, N., Kaneshige, N., Karagiorgi, G., Ketchum, W., Kirby, M., Kobilarcik, T., Kreslo, I., Lepetic, I., Li, J. -Y., Li, K., Li, Y., Lin, K., Littlejohn, B. R., Louis, W. C., Luo, X., Manivannan, K., Mariani, C., Marsden, D., Marshall, J., Caicedo, D. A. Martinez, Mason, K., Mastbaum, A., McConkey, N., Meddage, V., Mettler, T., Miller, K., Mills, J., Mistry, K., Mohayai, T., Mogan, A., Moon, J., Mooney, M., Moor, A. F., Moore, C. D., Lepin, L. Mora, Mousseau, J., Babu, S. Mulleria, Murphy, M., Naples, D., Navrer-Agasson, A., Nebot-Guinot, M., Neely, R. K., Newmark, D. A., Nowak, J., Nunes, M., Palamara, O., Paolone, V., Papadopoulou, A., Papavassiliou, V., Pate, S. F., Patel, N., Paudel, A., Pavlovic, Z., Piasetzky, E., Ponce-Pinto, I., Prince, S., Qian, X., Raaf, J. L., Radeka, V., Rafique, A., Reggiani-Guzzo, M., Ren, L., Rice, L. C. J., Rochester, L., Rondon, J. Rodriguez, Rosenberg, M., Ross-Lonergan, M., Scanavini, G., Schmitz, D. W., Schukraft, A., Seligman, W., Shaevitz, M. H., Sharankova, R., Shi, J., Sinclair, J., Smith, A., Snider, E. L., Soderberg, M., Soldner-Rembold, S., Spentzouris, P., Spitz, J., Stancari, M., John, J. St., Strauss, T., Sutton, K., Sword-Fehlberg, S., Szelc, A. M., Tang, W., Terao, K., Thorpe, C., Totani, D., Toups, M., Tsai, Y. -T., Uchida, M. A., Usher, T., Van De Pontseele, W., Viren, B., Weber, M., Wei, H., Williams, Z., Wolbers, S., Wongjirad, T., Wospakrik, M., Wresilo, K., Wright, N., Wu, W., Yandel, E., Yang, T., Yarbrough, G., Yates, L. E., Yu, F. J., Yu, H. W., Zeller, G. P., Zennamo, J., and Zhang, C.

Subjects
High Energy Physics - Experiment
Abstract

In this article, we describe a modified implementation of Mask Region-based Convolutional Neural Networks (Mask-RCNN) for cosmic ray muon clustering in a liquid argon TPC and applied to MicroBooNE neutrino data. Our implementation of this network, called sMask-RCNN, uses sparse submanifold convolutions to increase processing speed on sparse datasets, and is compared to the original dense version in several metrics. The networks are trained to use wire readout images from the MicroBooNE liquid argon time projection chamber as input and produce individually labeled particle interactions within the image. These outputs are identified as either cosmic ray muon or electron neutrino interactions. We find that sMask-RCNN has an average pixel clustering efficiency of 85.9% compared to the dense network's average pixel clustering efficiency of 89.1%. We demonstrate the ability of sMask-RCNN used in conjunction with MicroBooNE's state-of-the-art Wire-Cell cosmic tagger to veto events containing only cosmic ray muons. The addition of sMask-RCNN to the Wire-Cell cosmic tagger removes 70% of the remaining cosmic ray muon background events at the same electron neutrino event signal efficiency. This event veto can provide 99.7% rejection of cosmic ray-only background events while maintaining an electron neutrino event-level signal efficiency of 80.1%. In addition to cosmic ray muon identification, sMask-RCNN could be used to extract features and identify different particle interaction types in other 3D-tracking detectors., Comment: 30 pages, 21 figures

Published
2022

44. Do explanations increase the effectiveness of AI-crowd generated fake news warnings?

Author

Epstein, Ziv, Foppiani, Nicolò, Hilgard, Sophie, Sharma, Sanjana, Glassman, Elena, and Rand, David

Subjects
Computer Science - Human-Computer Interaction
Abstract

Social media platforms are increasingly deploying complex interventions to help users detect false news. Labeling false news using techniques that combine crowd-sourcing with artificial intelligence (AI) offers a promising way to inform users about potentially low-quality information without censoring content, but also can be hard for users to understand. In this study, we examine how users respond in their sharing intentions to information they are provided about a hypothetical human-AI hybrid system. We ask i) if these warnings increase discernment in social media sharing intentions and ii) if explaining how the labeling system works can boost the effectiveness of the warnings. To do so, we conduct a study ($N=1473$ Americans) in which participants indicated their likelihood of sharing content. Participants were randomly assigned to a control, a treatment where false content was labeled, or a treatment where the warning labels came with an explanation of how they were generated. We find clear evidence that both treatments increase sharing discernment, and directional evidence that explanations increase the warnings' effectiveness. Interestingly, we do not find that the explanations increase self-reported trust in the warning labels, although we do find some evidence that participants found the warnings with the explanations to be more informative. Together, these results have important implications for designing and deploying transparent misinformation warning labels, and AI-mediated systems more broadly., Comment: Forthcoming in ICWSM 2022

Published
2021

46. Mechanical Properties of Cocoon Silk Derivatives for Biomedical Application: A Systematic Review

Author

Alynah J. Adams, Maria J. Escobar-Domingo, Jose Foppiani, Agustin N. Posso, Dorien I. Schonebaum, Noelle Garbaccio, Jade E. Smith, Lacey Foster, Audrey K. Mustoe, Micaela Tobin, Bernard T. Lee, and Samuel J. Lin

Subjects
systematic review, silk, cocoon silk, mechanical properties, biomedicine, Technology
Abstract

Background: Despite cocoon silk’s well-known strength, biocompatibility, and hypoallergenic properties, its potential medical applications remain largely unexplored. This review, therefore, is of significance as it evaluates the mechanical properties and clinical potential of cocoon silk, a material with promising applications in biomaterials and tissue engineering. Methods: We conducted a comprehensive systematic review adhering to PRISMA guidelines. Our focus was on the primary outcomes of tensile strength and elongation at break, and the secondary outcomes included other mechanical properties, applications, and complications. Results: Out of the 192 silk-related studies, 9 met the criteria. These studies revealed that cocoon silk derivatives exhibit a wide range of tensile strength, from 0.464 to 483.9 MPa (with a median of 4.27 MPa), and elongation at break, from 2.56% to 946.5% (with a median of 60.0%). Biomedical applications of cocoon silk derivatives span from tissue regeneration (n = 6) to energy harvesting (n = 4). Complications often arose from material fragility in non-optimized derivative components. Conclusions: While cocoon silk shows expansive promise due to its suitable mechanical properties and low complication risk, plenty remains to be discovered. Future research is crucial to fully realizing its vast surgical and biomedical potential.

Published
2024
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