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3. Lung Ultrasound in COVID-19 Patients (LUS-COVID)

Author

Centre Hospitalier Universitaire de Brussels, Brussels, Belgium, Miulli Regional Hospital, Acquaviva delle Fonti, Italy, University of Foggia, University of Bari Aldo Moro, and Prof. Dr. Marcus J. Schultz, Prof. M.J. Schultz, MD, PhD

Published
2024

4. A digital teleneuropsychology platform for the diagnosis of mild cognitive impairment: from concept to certification as a medical device

Author

Panzavolta, Andrea, Cerami, Chiara, Caffarra, Paolo, De Vita, Dalila, Dodich, Alessandra, Fonti, Cristina, L’Abbate, Federica, Laganà, Valentina, Lavorgna, Luigi, Marra, Camillo, Papagno, Costanza, Pellegrini, Francesca Ferrari, Stracciari, Andrea, Trojano, Luigi, Iaquinta, Tiziana, Ravizza, Alice, Sternini, Federico, Pandolfi, Roberta, Sanzone, Sveva, Calore, Monica, and Cappa, Stefano F.

Published
2024
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5. Partial asynchrony of coniferous forest carbon sources and sinks at the intra-annual time scale

Author

Silvestro, Roberto, Mencuccini, Maurizio, García-Valdés, Raúl, Antonucci, Serena, Arzac, Alberto, Biondi, Franco, Buttò, Valentina, Camarero, J. Julio, Campelo, Filipe, Cochard, Hervé, Čufar, Katarina, Cuny, Henri E., de Luis, Martin, Deslauriers, Annie, Drolet, Guillaume, Fonti, Marina V., Fonti, Patrick, Giovannelli, Alessio, Gričar, Jožica, Gruber, Andreas, Gryc, Vladimír, Guerrieri, Rossella, Güney, Aylin, Guo, Xiali, Huang, Jian-Guo, Jyske, Tuula, Kašpar, Jakub, Kirdyanov, Alexander V., Klein, Tamir, Lemay, Audrey, Li, Xiaoxia, Liang, Eryuan, Lintunen, Anna, Liu, Feng, Lombardi, Fabio, Ma, Qianqian, Mäkinen, Harri, Malik, Rayees A., Martinez del Castillo, Edurne, Martinez-Vilalta, Jordi, Mayr, Stefan, Morin, Hubert, Nabais, Cristina, Nöjd, Pekka, Oberhuber, Walter, Olano, José M., Ouimette, Andrew P., Paljakka, Teemu V. S., Peltoniemi, Mikko, Peters, Richard L., Ren, Ping, Prislan, Peter, Rathgeber, Cyrille B. K., Sala, Anna, Saracino, Antonio, Saulino, Luigi, Schiestl-Aalto, Piia, Shishov, Vladimir V., Stokes, Alexia, Sukumar, Raman, Sylvain, Jean-Daniel, Tognetti, Roberto, Treml, Václav, Urban, Josef, Vavrčík, Hanuš, Vieira, Joana, von Arx, Georg, Wang, Yan, Yang, Bao, Zeng, Qiao, Zhang, Shaokang, Ziaco, Emanuele, and Rossi, Sergio

Published
2024
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6. Partial asynchrony of coniferous forest carbon sources and sinks at the intra-annual time scale

Author

Roberto Silvestro, Maurizio Mencuccini, Raúl García-Valdés, Serena Antonucci, Alberto Arzac, Franco Biondi, Valentina Buttò, J. Julio Camarero, Filipe Campelo, Hervé Cochard, Katarina Čufar, Henri E. Cuny, Martin de Luis, Annie Deslauriers, Guillaume Drolet, Marina V. Fonti, Patrick Fonti, Alessio Giovannelli, Jožica Gričar, Andreas Gruber, Vladimír Gryc, Rossella Guerrieri, Aylin Güney, Xiali Guo, Jian-Guo Huang, Tuula Jyske, Jakub Kašpar, Alexander V. Kirdyanov, Tamir Klein, Audrey Lemay, Xiaoxia Li, Eryuan Liang, Anna Lintunen, Feng Liu, Fabio Lombardi, Qianqian Ma, Harri Mäkinen, Rayees A. Malik, Edurne Martinez del Castillo, Jordi Martinez-Vilalta, Stefan Mayr, Hubert Morin, Cristina Nabais, Pekka Nöjd, Walter Oberhuber, José M. Olano, Andrew P. Ouimette, Teemu V. S. Paljakka, Mikko Peltoniemi, Richard L. Peters, Ping Ren, Peter Prislan, Cyrille B. K. Rathgeber, Anna Sala, Antonio Saracino, Luigi Saulino, Piia Schiestl-Aalto, Vladimir V. Shishov, Alexia Stokes, Raman Sukumar, Jean-Daniel Sylvain, Roberto Tognetti, Václav Treml, Josef Urban, Hanuš Vavrčík, Joana Vieira, Georg von Arx, Yan Wang, Bao Yang, Qiao Zeng, Shaokang Zhang, Emanuele Ziaco, and Sergio Rossi

Subjects
Science
Abstract

Abstract As major terrestrial carbon sinks, forests play an important role in mitigating climate change. The relationship between the seasonal uptake of carbon and its allocation to woody biomass remains poorly understood, leaving a significant gap in our capacity to predict carbon sequestration by forests. Here, we compare the intra-annual dynamics of carbon fluxes and wood formation across the Northern hemisphere, from carbon assimilation and the formation of non-structural carbon compounds to their incorporation in woody tissues. We show temporally coupled seasonal peaks of carbon assimilation (GPP) and wood cell differentiation, while the two processes are substantially decoupled during off-peak periods. Peaks of cambial activity occur substantially earlier compared to GPP, suggesting the buffer role of non-structural carbohydrates between the processes of carbon assimilation and allocation to wood. Our findings suggest that high-resolution seasonal data of ecosystem carbon fluxes, wood formation and the associated physiological processes may reduce uncertainties in carbon source-sink relationships at different spatial scales, from stand to ecosystem levels.

Published
2024
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7. Correction to: A digital teleneuropsychology platform for the diagnosis of mild cognitive impairment: from concept to certification as a medical device

Author

Panzavolta, Andrea, Cerami, Chiara, Caffarra, Paolo, De Vita, Dalila, Dodich, Alessandra, Fonti, Cristina, L’Abbate, Federica, Laganà, Valentina, Lavorgna, Luigi, Marra, Camillo, Papagno, Costanza, Pellegrini, Francesca Ferrari, Stracciari, Andrea, Trojano, Luigi, Iaquinta, Tiziana, Ravizza, Alice, Sternini, Federico, Pandolfi, Roberta, Sanzone, Sveva, Calore, Monica, and Cappa, Stefano F.

Published
2024
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9. Might patients with cerebellar ataxia benefit from the Computer Assisted Rehabilitation ENvironment (CAREN)? A pilot study focusing on gait and balance

Author

Mirjam Bonanno, Paolo De Pasquale, Cristiano De Marchis, Antonino Lombardo Facciale, Giuseppe Paladina, Bartolo Fonti, Angelo Quartarone, and Rocco Salvatore Calabrò

Subjects
CAREN, cerebellar ataxia, neurorehabilitation, virtual reality, gait analysis, Biotechnology, TP248.13-248.65
Abstract

Introduction: Ataxia is a neurological symptom that causes decreased balance, loss of coordination, and gait alterations. Innovative rehabilitation devices like virtual reality (VR) systems can provide task-oriented, repetitive and intensive training with multisensorial feedback, thus promoting neuroplastic processes. Among these VR technologies, the Computer Assisted Rehabilitation ENvironment (CAREN) associates a split belt treadmill on a 6-degrees of freedom platform with a 180° VR screen and a Vicon motion capture system to monitor patients’ movements during training sessions.Methods: Eight patients affected by cerebellar ataxia were enrolled and received 20 sessions of CAREN training in addition to standard rehabilitation treatment. Each patient was evaluated at the beginning and at the end of the study with 3D gait analysis and clinical scales to assess balance, gait function and risk of falls.Results: We found improvements in kinematic, kinetic, and electromyographic parameters (as per pre-post- CAREN training), as well as in clinical outcomes, such as balance and risk of falls in ataxic patients. In addition, we found that trunk rotation improved, after CAREN intervention, approximating to the normative values.Discussion: Our results suggested that CAREN might be useful to improve specific biomechanical parameters of gait in ataxic patients.

Published
2024
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13. Identification of hemodynamically stable patients with acute pulmonary embolism at high risk for death: external validation of different models

Author

Becattini, Cecilia, Gulizia, Michele M., Agnelli, Giancarlo, Dentali, Francesco, Di Lenarda, Andrea, Enea, Iolanda, Fabbri, Andrea, Maggioni, Aldo P., Pomero, Fulvio, Ruggeri, Maria Pia, Lucci, Donata, Vedovati, Maria Cristina, Duranti, Michele, Guercini, Francesco, Groff, Paolo, Verso, Melina, Fabbri, Gianna, Savoia, Martina, Baldini, Ester, Mecatti, Barbara Bartolomei, Bianchini, Francesca, Ceseri, Martina, Gonzini, Lucio, Gorini, Marco, Lorimer, Andrea, Orsini, Giampietro, Tricoli, Martina, Cimini, L.A., Becattini, C., Agnelli, G., Cesarini, V., Sanna, M., Pepe, G., Marchetti, C., Roldan, M. Olivan, Lenzi, L., Cozzio, S., Tomio, P., Diamanti, M., Beltrame, A., Glinski, L., Treleani, M., Coppa, A., Vanni, S., Bartalucci, P., Taccone, A., Costacurta, C., Bortolotti, P., Bortolussi, M., De Vecchi, M., Zanardi, F., Greco, I., Cosentini, R., Gerloni, R., Artusi, N., Cominotto, F., Sisto, U.G., Picariello, C., Roncon, L., Maddalozzo, A., Nitti, C., Riccomi, F., Buzzo, M., Bassanelli, G., Savonitto, S., Bianchi, A., Bilato, C., Lobascio, I., Dalla Valle, C., Pomata, D.P., Giostra, F., Tinuper, A.L., Zalunardo, B., Visonà, A., Panzavolta, C., Novelli, A., Bertini, A., Granai, C., Colombo, S., Periti, E., Bonacchini, L., Abrignani, M.G., Casciolo, M.F., D'Amato, A., Scardovi, A.B., Ricci, R., Iosi, S., Fontana, M.C., Marrazzo, A., Borselli, M., Di Fusco, S.A., Colivicchi, F., Enea, I., Triggiani, M., Papa, I., Pasini, G.F., Fioravanti, C., Panarello, S., Raggi, F., Marzolo, M., Cuppini, S., Milan, M., Barchetti, M., De Laura, D., Caldarola, P., Fiorini, R., Rastelli, G., Ameri, P., La Malfa, G., Cinelli, F., Sganzerla, P.C., Ubaldi, S., Sanchez, F.A., Forgione, C., Cuccia, C., Predieri, S., Fusco, S., Mumoli, N., Porta, C., Romei, M., Lucidi, M., Romaniello, A., Volpe, M., Mogni, P., Pizzolato, E., Martino, G.P., Bitti, G., Righini, G., Bandiera, G., Pennacchio, E., Limauro, S., Dachille, A., Ignone, G., Fuscaldo, G.F., De Rosa, F.M., Vazzana, N., Chesi, G., Di Filippo, F., Pierpaoli, L., Corapi, A., Vatrano, M., Angotti, C., Baccetti, F., Harari, S.A., Luisi, F., Daghini, E., De Curtis, E., Lucà, F., Ciancia, F., Blandizzi, S., Lettica, G.V., D'Orazio, S., Cosmi, F., Zaccaroni, S., Silingardi, M., Valeriano, V., Pugliese, F.R., Murgia, A.P., Parpaglia, P. Pinna, Martinelli, L., Caponi, C., Clemente, M.A., Ciccarone, A., Bongarzoni, A., Garagiola, M., Leone, M.C., Veropalumbo, M.R., Sacco, M., Morella, P., Dorigoni, S., Peterlana, D., Di Paola, R., Felis, S., Correale, M., Brunetti, N.D., Petrelli, G., Feliziani, F.T., Mastroiacovo, D., Romualdi, R., Pasin, F., Bonardi, S., Delfino, P., Scifo, C., Savioli, G., Ceresa, I.F., Galeotalanza, M., Benazzi, B., Porzio, M., Rosini, F., Ancona, C., Verrelli, C., Pasini, A. Fratta, Dalle Carbonare, L., Bozza, N., Nacci, F., Scarabelli, M.A., Amico, F., Marchesi, C., Mazzone, A., Di Tommaso, R., Cocco, F., Pezzuto, G., Luciani, A., Zamboni, P., Muriago, M., Del Pesce, L., Lucarini, A.R., Guglielmelli, E., Vannucchi, V., Moroni, F., Fichera, D., Malatino, L., Sgroi, C., Morana, I.M., Cicero, S., La Rosa, D., Mete, F., Gino, M., De Palma, A., Alessandri, M., Maestripieri, V., Battocchio, M., De Santis, M.T., Saladini, F., Corsi, D.C., Macarone Palmieri, N., Pierfranceschi, M. Giorgi, Palmonari, V., Fontanella, L., Airoldi, L., Bonocore, M., Paliani, U., Prat, L. Iogna, Chiecchi, L., Cuonzo, M., Paludo, A., Padula, D., Antonelli, A., Bicchi, M., Tota, G., Ariello, M., Sai, R., Civita, M., Tucci, M., Barbati, G., Conti, M., Cettina, R., Magnani, O., Levato, M., Gessi, V., De Rui, M., Bellizzi, A., Farneti, L., Salomone, P., Mannarini, A., Grifoni, E., Del Ghianda, S., Campodonico, J., De Cesare, N., Mutone, D., Pasoli, P., Meloni, S., Frenda, A., Viola, G., Torromeo, C., Campana, C., Pistone, M.C., Caravita, S., La Creta, C.P., Miscio, F., Loreno, M., Fenu, P., Mazzetti, M., Rossini, D., Brunacci, M., Capuano, A., Tagliamonte, G., Pinelli, M., Ballocca, F., Parca, G., Pasini, S.M., Maragno, M.G., Vecchi, F., Mancinelli, L., Cavalli, A., Di Mare, F., Conficoni, E., Miceli, R., Pecoraro, R., Fonti, C., Pegoraro, S., Piccinni, G.C., Caruso, G., Boriani, G., Lanzillotta, P., Piccolo, P., Calò, L., Stolfo, D., Mangiacapra, S., Marziali, A., Volponi, M.C., Querci, G., Terribile, R., Menabue, M., Fiorentini, A., Musci, R.L., Uras, S., Cicini, M.P., Manetti, S., Francese, G.M., Melchio, R., Scorpiglione, N., Carrara, D., Pani, A., Morisco, C., Rodolico, M., Colombo, Silvia, Vanni, Simone, Abrignani, Maurizio Giuseppe, Scardovi, Angela Beatrice, Marrazzo, Alessandra, Borselli, Matteo, Barchetti, Marco, and Maggioni, Aldo Pietro

Published
2024
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14. Age at Tumor Diagnosis in 14,636 Canine Cases from the Pathology-Based UNIPI Animal Cancer Registry, Italy: One Size Doesn’t Fit All

Author

Niccolò Fonti, Francesca Parisi, Alessio Lachi, Elena Sophie Dhein, Franco Guscetti, Alessandro Poli, and Francesca Millanta

Subjects
age, neoplasia, dogs, Animal Cancer Registry, veterinary oncology, sex, Veterinary medicine, SF600-1100
Abstract

Cancer is the most common cause of death in adult dogs. All dogs would benefit from early diagnosis, but there are no specific guidelines regarding the schedule of cancer screening in companion animals. The aim of this study was to retrospectively evaluate the age at diagnosis in Italian oncological canine patients. A total of 14,636 canine histologically confirmed neoplastic cases were coded according to the Vet-ICD-O-canine-1 and stratified by malignancy, sex, neutering status, breed, cephalic index, body size, and tumor type. Differences in age distribution were analyzed and the influence of these variables on the time of first malignancy diagnosis was assessed using an event history analysis model. The median age at diagnosis for benign and malignant tumors was 9 and 10 years, respectively. Intact and purebred dogs were diagnosed earlier, but the median age differed significantly by breed. The earliest age at diagnosis was recorded for lymphomas and mast cell tumors. The model showed an accelerating effect of large size, brachy- and dolichocephaly, and sexual integrity in female dogs on the time of malignancy diagnosis. Our results confirm that a “one-size-fits-all” approach to cancer screening is not accurate in dogs and provide relevant data that may lead to the establishment of breed-based screening schedules.

Published
2024
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16. A machine learning model to predict the risk of perinatal depression: Psychosocial and sleep-related factors in the Life-ON study cohort

Author

Aquilino, Daniele, Baiardi, Simone, Bianconcini, Alessandra, Canevini, Mariapaola, Cicolin, Alessandro, Cirignotta, Fabio, D'Agostino, Armando, Giudice, Renata Del, Fanti, Valentina, Filippakos, Filippos, Fior, Giulia, Fonti, Cristina, Furia, Francesca, Gambini, Orsola, Garbazza, Corrado, Giordano, Alessandra, Giordano, Barbara, Manconi, Mauro, Marconi, Anna Maria, Martini, Alma, Mondini, Susanna, Piazza, Nicoletta, Raimondo, Erika, Riccardi, Silvia, Rizzo, Nicola, Santoro, Rossella, Serrati, Chiara, Simonazzi, Giuliana, Stein, Hans-Christian, Zambrelli, Elena, Mangili, Francesca, D'Onofrio, Tatiana Adele, and Malpetti, Daniele

Published
2024
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20. Revealing legacy effects of extreme droughts on tree growth of oaks across the Northern Hemisphere

Author

Bose, Arun K., Doležal, Jiri, Scherrer, Daniel, Altman, Jan, Ziche, Daniel, Martínez-Sancho, Elisabet, Bigler, Christof, Bolte, Andreas, Colangelo, Michele, Dorado-Liñán, Isabel, Drobyshev, Igor, Etzold, Sophia, Fonti, Patrick, Gessler, Arthur, Kolář, Tomáš, Koňasová, Eva, Korznikov, Kirill Aleksandrovich, Lebourgeois, François, Lucas-Borja, Manuel Esteban, Menzel, Annette, Neuwirth, Burkhard, Nicolas, Manuel, Omelko, Alexander Mikhaylovich, Pederson, Neil, Petritan, Any Mary, Rigling, Andreas, Rybníček, Michal, Scharnweber, Tobias, Schröder, Jens, Silla, Fernando, Sochová, Irena, Sohar, Kristina, Ukhvatkina, Olga Nikolaevna, Vozmishcheva, Anna Stepanovna, Zweifel, Roman, and Camarero, J. Julio

Published
2024
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21. High preseason temperature variability drives convergence of xylem phenology in the Northern Hemisphere conifers

Author

Zhang, Yaling, Huang, Jian-Guo, Wang, Minhuang, Wang, Wenjin, Deslauriers, Annie, Fonti, Patrick, Liang, Eryuan, Mäkinen, Harri, Oberhuber, Walter, Rathgeber, Cyrille B.K., Tognetti, Roberto, Treml, Václav, Yang, Bao, Zhai, Lihong, Antonucci, Serena, Buttò, Valentina, Camarero, J. Julio, Campelo, Filipe, Čufar, Katarina, De Luis, Martin, Fajstavr, Marek, Giovannelli, Alessio, Gričar, Jožica, Gruber, Andreas, Gryc, Vladimír, Güney, Aylin, Jyske, Tuula, Kašpar, Jakub, King, Gregory, Krause, Cornelia, Lemay, Audrey, Lombardi, Fabio, del Castillo, Edurne Martínez, Morin, Hubert, Nabais, Cristina, Nöjd, Pekka, Peters, Richard L., Prislan, Peter, Saracino, Antonio, Shishov, Vladimir V., Swidrak, Irene, Vavrčík, Hanuš, Vieira, Joana, Zeng, Qiao, and Rossi, Sergio

Published
2024
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24. Optimal risk and diagnosis assessment strategies in perinatal depression: A machine learning approach from the life-ON study cohort

Author

Aquilino, Daniele, Baiardi, Simone, Bianconcini, Alessandra, Canevini, Mariapaola, Cicolin, Alessandro, Cirignotta, Fabio, D'Agostino, Armando, Giudice, Renata Del, Fanti, Valentina, Filippakos, Filippos, Fior, Giulia, Fonti, Cristina, Furia, Francesca, Gambini, Orsola, Garbazza, Corrado, Giordano, Alessandra, Giordano, Barbara, Manconi, Mauro, Marconi, Anna Maria, Martini, Alma, Mondini, Susanna, Piazza, Nicoletta, Raimondo, Erika, Riccardi, Silvia, Rizzo, Nicola, Santoro, Rossella, Serrati, Chiara, Simonazzi, Giuliana, Stein, Hans-Christian, Zambrelli, Elena, Malpetti, Daniele, Azzimonti, Laura, Mangili, Francesca, and del Giudice, Renata

Published
2024
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27. Sleep and sleep disorders during pregnancy and postpartum: The Life-ON study

Author

Manconi, Mauro, van der Gaag, Linda C., Mangili, Francesca, Garbazza, Corrado, Riccardi, Silvia, Cajochen, Christian, Mondini, Susanna, Furia, Francesca, Zambrelli, Elena, Baiardi, Simone, Giordano, Alessandra, Rizzo, Nicola, Fonti, Cristina, Viora, Elsa, D'Agostino, Armando, Cicolin, Alessandro, Cirignotta, Fabio, Aquilino, Daniele, Barassi, Alessandra, del Giudice, Renata, Fior, Giulia, Gambini, Orsola, Giordano, Barbara, Martini, Alma, Serrati, Chiara, Stefanelli, Rossana, Scarone, Silvio, Canevini, Mariapaola, Fanti, Valentina, Stein, Hans-Christian, Marconi, Anna Maria, Raimondo, Erica, Viglietta, Emanuela, Santoro, Rossella, Simonazzi, Giuliana, Bianconcini, Alessandra, Meani, Francesco, Piazza, Nicoletta, Filippakos, Filippos, and Gyr, Thomas

Published
2024
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28. Quantitative wood anatomy and stable carbon isotopes indicate pronounced drought exposure of Scots pine when growing at the forest edge

Author

Allan Buras, Romy Rehschuh, Marina Fonti, Jelena Lange, Patrick Fonti, Annette Menzel, Arthur Gessler, Andreas Rigling, Kerstin Treydte, and Georg von Arx

Subjects
tree rings, hotter drought, forest microclimate, tree physiology, dieback, Pinus sylvestris, Forestry, SD1-669.5, Environmental sciences, GE1-350
Abstract

Climate change poses a major threat to global forest ecosystems. In particular, rising temperatures and prolonged drought spells have led to increased rates of forest decline and dieback in recent decades. Under this framework, forest edges are particularly prone to drought-induced decline since they are characterized by warmer and drier micro-climatic conditions amplifying impacts of drought on tree growth and survival. Previous research indicated that forest-edge Scots pine trees have a higher growth sensitivity to water availability compared to the forest interior with consequent reduction of canopy greenness (remotely sensed NDVI) and higher mortality rates. Yet, the underlying physiological mechanisms remain largely unknown. Here, we address this knowledge gap by comparing stable carbon isotope signatures and wood anatomical traits in annual rings of trees growing at the forest edge vs. the forest interior and between trees that either survived or died during the extreme drought of 2015. Our analyses suggest that the exposure to drought of forest-edge Scots pine likely results in a reduction of stomatal conductance, as reflected by a higher δ13C of stem wood, thinner cell walls, and lower mean ring density. Moreover, we found dead trees to feature larger mean hydraulic lumen diameters and a lower cell-wall reinforcement, indicating a higher risk to suffer from cavitation. In conclusion, the typically drier micro-climatic conditions at the forest edge seem to have triggered a larger reduction of stomatal conductance of Scots pine trees, resulting in a lower carbon availability and significantly altered wood anatomical properties under an increasingly drier climate.

Published
2023
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29. Cancerogenic parasites in veterinary medicine: a narrative literature review

Author

Niccolò Fonti, Francesca Parisi, Francesca Mancianti, Giulia Freer, and Alessandro Poli

Subjects
Cancer, Parasites, Veterinary oncology, Spirocerca, Flukes, Theileria, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Parasite infection is one of the many environmental factors that can significantly contribute to carcinogenesis and is already known to be associated with a variety of malignancies in both human and veterinary medicine. However, the actual number of cancerogenic parasites and their relationship to tumor development is far from being fully understood, especially in veterinary medicine. Thus, the aim of this review is to investigate parasite-related cancers in domestic and wild animals and their burden in veterinary oncology. Spontaneous neoplasia with ascertained or putative parasite etiology in domestic and wild animals will be reviewed, and the multifarious mechanisms of protozoan and metazoan cancer induction will be discussed.

Published
2023
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30. Exploring the link between viruses and cancer in companion animals: a comprehensive and comparative analysis

Author

Francesca Parisi, Niccolò Fonti, Francesca Millanta, Giulia Freer, Mauro Pistello, and Alessandro Poli

Subjects
Cancer, Cat, Dog, FeLV, FIV, Gammaherpesvirus, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Currently, it is estimated that 15% of human neoplasms globally are caused by infectious agents, with new evidence emerging continuously. Multiple agents have been implicated in various forms of neoplasia, with viruses as the most frequent. In recent years, investigation on viral mechanisms underlying tumoral transformation in cancer development and progression are in the spotlight, both in human and veterinary oncology. Oncogenic viruses in veterinary medicine are of primary importance not only as original pathogens of pets, but also in the view of pets as models of human malignancies. Hence, this work will provide an overview of the main oncogenic viruses of companion animals, with brief notes of comparative medicine.

Published
2023
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31. Impacts of site aridity on intra-annual radial variation of two alpine coniferous species in cold and dry ecosystems

Author

Junzhou Zhang, Xiaohua Gou, Yuetong Wang, Qipeng Sun, Junjun Liu, Fang Wang, Min Xu, Jiqin Yang, and Patrick Fonti

Subjects
Different species, Dendrometer, Drought, Tibetan Plateau, Tree growth, Ecology, QH540-549.5
Abstract

Climate change alters regional aridity and species composition in dryland ecosystems. However, the effect of varying aridity and species-specific responses on tree growth remains unclear. Here, we used high-resolution dendrometers to analyze the climatic factors controlling stem diameter variation in two alpine coniferous species, Qilian juniper (Juniperus przewalskii) and Qinghai spruce (Picea crassifolia), in their eastern- and western-most distributions (two species × two sites) in the Qilian Mountains during the 2018–2021 growing seasons. We observed species-, site-, and year-specific differences in growth phenology and radial growth dynamics. Juniper had early growth onset and cessation, but short growing season compared to spruce. Trees in the eastern sites showed earlier growth onset, later cessation, and a much longer growing season than those in the western sites for both species. Daily stem growth revealed similar responses for both species and site aridity, with daily vapor pressure deficit, maximum temperature, and solar radiation negatively, and relative humidity and precipitation positively affecting stem increments. However, when observation was extended to 7 or 21 days, the effect of precipitation on stem increments became weak or negligible in the wetter eastern sites, while continuing in the arid western sites. Further, soil water content appeared to have an impact on growth in the arid western site for both species. These results were confirmed by linear mixed-effects models, which revealed that site-aridity play an important role on tree stem variation, especially in junipers. Our results suggest that although short-term atmospheric water conditions influence radial stem variation, intra-annual tree growth still depends on soil water availability in drylands. Our findings provide new evidence of potential uses of dendrometers to measure environmental stress on tree growth and reveal that site aridity and species influence tree growth at different time scales in cold and arid ecosystems.

Published
2024
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32. Leptin signaling in the dorsomedial hypothalamus couples breathing and metabolism in obesity

Author

Mateus R. Amorim, Xin Wang, O. Aung, Shannon Bevans-Fonti, Frederick Anokye-Danso, Caitlin Ribeiro, Joan Escobar, Carla Freire, Huy Pho, Olga Dergacheva, Luiz G.S. Branco, Rexford S. Ahima, David Mendelowitz, and Vsevolod Y. Polotsky

Subjects
CP: Neuroscience, CP: Metabolism, Biology (General), QH301-705.5
Abstract

Summary: Mismatch between CO2 production (Vco2) and respiration underlies the pathogenesis of obesity hypoventilation. Leptin-mediated CNS pathways stimulate both metabolism and breathing, but interactions between these functions remain elusive. We hypothesized that LEPRb+ neurons of the dorsomedial hypothalamus (DMH) regulate metabolism and breathing in obesity. In diet-induced obese LeprbCre mice, chemogenetic activation of LEPRb+ DMH neurons increases minute ventilation (Ve) during sleep, the hypercapnic ventilatory response, Vco2, and Ve/Vco2, indicating that breathing is stimulated out of proportion to metabolism. The effects of chemogenetic activation are abolished by a serotonin blocker. Optogenetic stimulation of the LEPRb+ DMH neurons evokes excitatory postsynaptic currents in downstream serotonergic neurons of the dorsal raphe (DR). Administration of retrograde AAV harboring Cre-dependent caspase to the DR deletes LEPRb+ DMH neurons and abolishes metabolic and respiratory responses to leptin. These findings indicate that LEPRb+ DMH neurons match breathing to metabolism through serotonergic pathways to prevent obesity-induced hypoventilation.

Published
2023
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34. Anatomical, Developmental and Physiological Bases of Tree-Ring Formation in Relation to Environmental Factors

Author

Rathgeber, Cyrille B. K., Pérez-de-Lis, Gonzalo, Fernández-de-Uña, Laura, Fonti, Patrick, Rossi, Sergio, Treydte, Kerstin, Gessler, Arthur, Deslauriers, Annie, Fonti, Marina V., Ponton, Stéphane, Meinzer, Frederick C., Series Editor, Niinemets, Ülo, Series Editor, Siegwolf, Rolf T. W., editor, Brooks, J. Renée, editor, Roden, John, editor, and Saurer, Matthias, editor

Published
2022
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36. AusTraits, a curated plant trait database for the Australian flora

Author

Falster, Daniel, Gallagher, Rachael, Wenk, Elizabeth H, Wright, Ian J, Indiarto, Dony, Andrew, Samuel C, Baxter, Caitlan, Lawson, James, Allen, Stuart, Fuchs, Anne, Monro, Anna, Kar, Fonti, Adams, Mark A, Ahrens, Collin W, Alfonzetti, Matthew, Angevin, Tara, Apgaua, Deborah MG, Arndt, Stefan, Atkin, Owen K, Atkinson, Joe, Auld, Tony, Baker, Andrew, von Balthazar, Maria, Bean, Anthony, Blackman, Chris J, Bloomfield, Keith, Bowman, David MJS, Bragg, Jason, Brodribb, Timothy J, Buckton, Genevieve, Burrows, Geoff, Caldwell, Elizabeth, Camac, James, Carpenter, Raymond, Catford, Jane A, Cawthray, Gregory R, Cernusak, Lucas A, Chandler, Gregory, Chapman, Alex R, Cheal, David, Cheesman, Alexander W, Chen, Si-Chong, Choat, Brendan, Clinton, Brook, Clode, Peta L, Coleman, Helen, Cornwell, William K, Cosgrove, Meredith, Crisp, Michael, Cross, Erika, Crous, Kristine Y, Cunningham, Saul, Curran, Timothy, Curtis, Ellen, Daws, Matthew I, DeGabriel, Jane L, Denton, Matthew D, Dong, Ning, Du, Pengzhen, Duan, Honglang, Duncan, David H, Duncan, Richard P, Duretto, Marco, Dwyer, John M, Edwards, Cheryl, Esperon-Rodriguez, Manuel, Evans, John R, Everingham, Susan E, Farrell, Claire, Firn, Jennifer, Fonseca, Carlos Roberto, French, Ben J, Frood, Doug, Funk, Jennifer L, Geange, Sonya R, Ghannoum, Oula, Gleason, Sean M, Gosper, Carl R, Gray, Emma, Groom, Philip K, Grootemaat, Saskia, Gross, Caroline, Guerin, Greg, Guja, Lydia, Hahs, Amy K, Harrison, Matthew Tom, Hayes, Patrick E, Henery, Martin, Hochuli, Dieter, Howell, Jocelyn, Huang, Guomin, Hughes, Lesley, Huisman, John, Ilic, Jugoslav, Jagdish, Ashika, Jin, Daniel, Jordan, Gregory, Jurado, Enrique, Kanowski, John, and Kasel, Sabine

Subjects
Plant Biology, Biological Sciences, Ecology, Australia, Databases, Factual, Phenotype, Plant Physiological Phenomena, Plants
Abstract

We introduce the AusTraits database - a compilation of values of plant traits for taxa in the Australian flora (hereafter AusTraits). AusTraits synthesises data on 448 traits across 28,640 taxa from field campaigns, published literature, taxonomic monographs, and individual taxon descriptions. Traits vary in scope from physiological measures of performance (e.g. photosynthetic gas exchange, water-use efficiency) to morphological attributes (e.g. leaf area, seed mass, plant height) which link to aspects of ecological variation. AusTraits contains curated and harmonised individual- and species-level measurements coupled to, where available, contextual information on site properties and experimental conditions. This article provides information on version 3.0.2 of AusTraits which contains data for 997,808 trait-by-taxon combinations. We envision AusTraits as an ongoing collaborative initiative for easily archiving and sharing trait data, which also provides a template for other national or regional initiatives globally to fill persistent gaps in trait knowledge.

Published
2021

37. Global transpiration data from sap flow measurements: the SAPFLUXNET database

Author

Poyatos, Rafael, Granda, Víctor, Flo, Víctor, Adams, Mark A, Adorján, Balázs, Aguadé, David, Aidar, Marcos PM, Allen, Scott, Alvarado-Barrientos, M Susana, Anderson-Teixeira, Kristina J, Aparecido, Luiza Maria, Arain, M Altaf, Aranda, Ismael, Asbjornsen, Heidi, Baxter, Robert, Beamesderfer, Eric, Berry, Z Carter, Berveiller, Daniel, Blakely, Bethany, Boggs, Johnny, Bohrer, Gil, Bolstad, Paul V, Bonal, Damien, Bracho, Rosvel, Brito, Patricia, Brodeur, Jason, Casanoves, Fernando, Chave, Jérôme, Chen, Hui, Cisneros, Cesar, Clark, Kenneth, Cremonese, Edoardo, Dang, Hongzhong, David, Jorge S, David, Teresa S, Delpierre, Nicolas, Desai, Ankur R, C., Frederic, Dohnal, Michal, Domec, Jean-Christophe, Dzikiti, Sebinasi, Edgar, Colin, Eichstaedt, Rebekka, El-Madany, Tarek S, Elbers, Jan, Eller, Cleiton B, Euskirchen, Eugénie S, Ewers, Brent, Fonti, Patrick, Forner, Alicia, Forrester, David I, Freitas, Helber C, Galvagno, Marta, Garcia-Tejera, Omar, Ghimire, Chandra Prasad, Gimeno, Teresa E, Grace, John, Granier, André, Griebel, Anne, Guangyu, Yan, Gush, Mark B, Hanson, Paul J, Hasselquist, Niles J, Heinrich, Ingo, Hernandez-Santana, Virginia, Herrmann, Valentine, Hölttä, Teemu, Holwerda, Friso, Irvine, James, Ayutthaya, Supat Isarangkool Na, Jarvis, Paul G, Jochheim, Hubert, Joly, Carlos A, Kaplick, Julia, Kim, Hyun Seok, Klemedtsson, Leif, Kropp, Heather, Lagergren, Fredrik, Lane, Patrick, Lang, Petra, Lapenas, Andrei, Lechuga, Víctor, Lee, Minsu, Leuschner, Christoph, Limousin, Jean-Marc, Linares, Juan Carlos, Linderson, Maj-Lena, Lindroth, Anders, Llorens, Pilar, López-Bernal, Álvaro, Loranty, Michael M, Lüttschwager, Dietmar, Macinnis-Ng, Cate, Maréchaux, Isabelle, Martin, Timothy A, Matheny, Ashley, McDowell, Nate, McMahon, Sean, Meir, Patrick, and Mészáros, Ilona

Subjects
Life on Land, Atmospheric Sciences, Geochemistry, Physical Geography and Environmental Geoscience
Abstract

Plant transpiration links physiological responses of vegetation to water supply and demand with hydrological, energy, and carbon budgets at the land-atmosphere interface. However, despite being the main land evaporative flux at the global scale, transpiration and its response to environmental drivers are currently not well constrained by observations. Here we introduce the first global compilation of whole-plant transpiration data from sap flow measurements (SAPFLUXNET, https://sapfluxnet.creaf.cat/, last access: 8 June 2021). We harmonized and quality-controlled individual datasets supplied by contributors worldwide in a semi-automatic data workflow implemented in the R programming language. Datasets include sub-daily time series of sap flow and hydrometeorological drivers for one or more growing seasons, as well as metadata on the stand characteristics, plant attributes, and technical details of the measurements. SAPFLUXNET contains 202 globally distributed datasets with sap flow time series for 2714 plants, mostly trees, of 174 species. SAPFLUXNET has a broad bioclimatic coverage, with woodland/shrubland and temperate forest biomes especially well represented (80% of the datasets). The measurements cover a wide variety of stand structural characteristics and plant sizes. The datasets encompass the period between 1995 and 2018, with 50% of the datasets being at least 3 years long. Accompanying radiation and vapour pressure deficit data are available for most of the datasets, while on-site soil water content is available for 56% of the datasets. Many datasets contain data for species that make up 90% or more of the total stand basal area, allowing the estimation of stand transpiration in diverse ecological settings. SAPFLUXNET adds to existing plant trait datasets, ecosystem flux networks, and remote sensing products to help increase our understanding of plant water use, plant responses to drought, and ecohydrological processes. SAPFLUXNET version 0.1.5 is freely available from the Zenodo repository (10.5281/zenodo.3971689; Poyatos et al., 2020a). The "sapfluxnetr"R package-designed to access, visualize, and process SAPFLUXNET data-is available from CRAN.

Published
2021

38. Histiocytic Sarcoma in a Captive Hybrid Orangutan (Pongo sp.): Morphological and Immunohistochemical Features

Author

Valentina Galietta, Niccolò Fonti, Cristiano Cocumelli, Caterina Raso, Pilar Di Cerbo, Francesca Parisi, Emanuela Bovi, Raffaella Parmigiani, Gabriele Pietrella, Antonella Cersini, Klaus G. Friedrich, and Claudia Eleni

Subjects
histiocytic sarcoma (HS), non-human primates (NHPs), immunohistochemistry, neoplasia, orangutan, Veterinary medicine, SF600-1100, Zoology, QL1-991
Abstract

Histiocytic sarcoma (HS), an infrequent highly aggressive hematopoietic tumor, has been observed in diverse animal species, with isolated occurrences in non-human primates. This study describes the first case of disseminated HS in a 45-year-old female hybrid captive orangutan. The clinical profile mirrored symptoms seen in human HS cases, encompassing anorexia and ascites. Detailed histopathological examination demonstrated characteristic features of this tumor and immunohistochemistry, using markers such as Iba-1 and HLA-DR, confirmed the diagnosis. Significantly, the absence of CD163 and CD204 expression challenges their diagnostic utility in non-human primates. This investigation enhances our understanding of HS diagnosis in non-human primates, underscoring the necessity for standardized markers and diagnostic protocols.

Published
2024
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39. Intra-annual dynamic of opposite and compression wood formation of Pinus massoniana Lamb. in humid subtropical China

Author

Chunsong Wang, Zhuangpeng Zheng, Feifei Zhou, Xinsheng Liu, Patrick Fonti, Jiani Gao, and Keyan Fang

Subjects
microcore, compression wood, tree rings, wood anatomy, xylogenesis, subtropical China, Forestry, SD1-669.5, Environmental sciences, GE1-350
Abstract

Radial growth of trees can result in opposite wood (OW) and compression wood (CW) due to the varying impact of stem mechanical stress, such as that caused by gravity or wind. Previous research has identified higher xylem production in CW compared to OW. Yet, it remains unclear whether the difference in the number of xylem cells between OW and CW results from differences in growth rate or the duration of xylem cells. In this study, we collected wood microcores on a weekly basis from March 2019 to January 2020 in Pinus massoniana Lamb. located on a steep slope. Our objective was to compare the dynamic of cambial activity and resulting cellular anatomical parameters between OW and CW in a humid subtropical environment. Our results showed that the xylem phenology of OW and CW was generally consistent with the xylem cell division process beginning in early March and ceasing in November. The last latewood cell completed its differentiation at the end of December. The response of wood formation dynamics to climate was consistent in both OW and CW. Moreover, both wood types exhibited a limited development of the enlargement phase due to the heat and drought during the summer. The rate of cell division was responsible for 90.7% of the variability in the number of xylem cells. The CW xylem obtained a larger number of cells by increasing the rate of cell division and displayed thinner earlywood cells with larger lumens than OW cells. Our findings showed that the xylem of conifer species responds to mechanical stress by accelerating the cell division rate. As a result, we suggest calculating the ratio between OW and CW widths to reconstruct wind stress changes rather than calculating the residuals used in the current study.

Published
2023
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45. Stable Isotopes in Tree Rings of Boreal Forests

Author

Churakova, Olga V., Porter, Trevor J., Kirdyanov, Alexander V., Myglan, Vladimir S., Fonti, Marina V., Vaganov, Eugene A., Meinzer, Frederick C., Series Editor, Niinemets, Ülo, Series Editor, Siegwolf, Rolf T. W., editor, Brooks, J. Renée, editor, Roden, John, editor, and Saurer, Matthias, editor

Published
2022
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46. Dendrochronology: Fundamentals and Innovations

Author

Frank, David, Fang, Keyan, Fonti, Patrick, Meinzer, Frederick C., Series Editor, Niinemets, Ülo, Series Editor, Siegwolf, Rolf T. W., editor, Brooks, J. Renée, editor, Roden, John, editor, and Saurer, Matthias, editor

Published
2022
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48. Effectiveness of Liposomial Ozonized-Oil for Cataract Surgery

Author

Azienda Policlinico Umberto I, Roma, Università degli Studi del Molise, Clinica Oculistica, Clinica Mediterranea, Napoli, Ospedale Santa Croce-Carle Cuneo, Centro Medico Oculistico ALSO, Saronno, Fondazione G.B. Bietti, IRCCS , Roma, Ospedale San Carlo di Nancy, Roma, Centro oftalmologico LASERVISTA, Caserta, Casa di cura GEPOS, Telese, Azienda Ospedaliero-Universitaria Consorziale, Bari, Ospedale generale regionale F. Miulli, Acquaviva delle Fonti, Azienda Ospedaliera Universitaria Mater Domini, Catanzaro, Ospedale Policlinico Casilino, Roma, Ospedale G. Panico, Tricase, Studio oculistico Laborante, Studio oculistico Franchini, U.C.O Ospedali Civico di Cristina Benfratelli, and A.O.U. Città della Salute e della Scienza - Molinette Hospital

Published
2021

49. Assessing intra-annual density fluctuations across and along white pine stems

Author

Miller, Elise W., Rademacher, Tim, Fonti, Patrick, Seyednasrollah, Bijan, and Richardson, Andrew D.

Subjects
Wood -- Properties, Spatial analysis (Statistics) -- Usage, White pine -- Growth, Company growth, Biological sciences
Abstract

Intra-annual density fluctuations (IADFs) are triggered by environmental cues, but whether they are distributed uniformly throughout the stem is not well documented. The spatial distribution of IADFs could help us understand variations in cambial sensitivity to environmental cues throughout the tree. We investigate how IADF distribution varies radially, longitudinally, and circumferentially within white pine (Pinus strobus L.) stems. We took wood samples at breast height, near branches, and at the top of the trees. We identified IADFs visually and measured their radial position within a ring as well as their circumferential arc in cross-sections. Intra-annual density fluctuations occurred in 22.2% of rings. The radial position of IADFs within a ring was remarkably consistent at roughly 80% of the total annual radial increment across heights, trees, and years of formation. The main factors affecting the likelihood of IADF occurrence were ring width, year of formation, and the interaction between the two. Being near branches or at the top of the tree slightly increased the probability of occurrence. Though the sample size was not large enough to provide conclusive results about the circumferential distribution of IADFs, our data suggest that the circumferential arc of the IADFs might be conserved throughout the stem. Key words: carbon, climate, false rings, IADFs, white pine, wood density, wood anatomy, wood formation, xylogenesis. Les fluctuations intra-annuelles de densite (FIAD) sont declenchees par des signaux environnementaux, mais leur distribution uniforme dans la tige n'est pas bien documentee. La distribution spatiale des FIAD pourrait aider les chercheurs a comprendre les variations de la sensibilite du cambium aux signaux environnementaux a travers l'arbre. Les auteurs examinent comment la distribution des FIAD varie radialement, longitudinalement et de maniere circonferentielle dans les tiges de pin blanc (Pinus strobus L.). Ils ont preleve des echantillons de bois a hauteur de poitrine, pres des branches et a la cime des arbres. Ils ont identifie visuellement les FIAD et mesure leur position radiale a l'interieur d'un anneau ainsi que leur arc circonferentiel dans les coupes transversales. Les FIAD etaient presentes dans 22,2 % des cernes. La position radiale des FIAD a l'interieur d'un anneau etait remarquablement constante a environ 80 % de l'increment radial annuel total a travers les hauteurs, les arbres et les annees de formation. Les principaux facteurs affectant la probabilite d'apparition de FIAD etaient la largeur du cerne, l'annee de formation et l'interaction entre les deux. Le fait d'etre pres des branches ou au sommet de l'arbre augmentait legerement la probabilite d'apparition. La taille de l'echantillon n'etait pas assez importante pour fournir des resultats concluants sur la distribution circonferentielle des FIAD, bien que les donnees suggerent que l'arc circonferentiel des FIAD pourrait etre conserve tout au long de la tige. [Traduit par la Redaction] Mots-cles: carbone, climat, faux cernes, FIAD, pin blanc, densite du bois, anatomie du bois, formation du bois, xylogenese., Introduction Annual wood growth rings, which are formed in seasonal climates, illustrate how wood formation varies inter- and intra-annually in trees. In temperate and boreal conifers, radial growth generally transitions [...]

Published
2022
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50. A machine learning model to predict the risk of perinatal depression: Psychosocial and sleep-related factors in the Life-ON study cohort

Author

Garbazza, Corrado, primary, Mangili, Francesca, additional, D'Onofrio, Tatiana Adele, additional, Malpetti, Daniele, additional, Riccardi, Silvia, additional, Cicolin, Alessandro, additional, D'Agostino, Armando, additional, Cirignotta, Fabio, additional, Manconi, Mauro, additional, Aquilino, Daniele, additional, Baiardi, Simone, additional, Bianconcini, Alessandra, additional, Canevini, Mariapaola, additional, Giudice, Renata Del, additional, Fanti, Valentina, additional, Filippakos, Filippos, additional, Fior, Giulia, additional, Fonti, Cristina, additional, Furia, Francesca, additional, Gambini, Orsola, additional, Garbazza, Corrado, additional, Giordano, Alessandra, additional, Giordano, Barbara, additional, Marconi, Anna Maria, additional, Martini, Alma, additional, Mondini, Susanna, additional, Piazza, Nicoletta, additional, Raimondo, Erika, additional, Rizzo, Nicola, additional, Santoro, Rossella, additional, Serrati, Chiara, additional, Simonazzi, Giuliana, additional, Stein, Hans-Christian, additional, and Zambrelli, Elena, additional

Published
2024
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