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Dabrafenib plus trametinib is a promising new therapy for patients affected by BRAFV600E-mutant glioma, with high overall response and manageable toxicity. We described a complete and long-lasting response in a case of recurrent anaplastic pleomorphic xanthoastrocytoma CNS WHO-grade 3 BRAFV600E mutated. Due to very poor prognosis, there are a few described cases of highgrade glioma (HGG) patients treated with the combined target therapy as thirdline treatment. The emergence of optimized sequencing strategies and targeted agents, including multimodal and systemic therapy with dabrafenib plus trametinib, will continue to broaden personalized therapy in HGG improving patient outcomes. [ABSTRACT FROM AUTHOR]

Low grade gliomas (LGGs) of pineal region are usually difficult to remove and they frequently relapse or progress after front line chemotherapy. Bevacizumab-Irinotecan (BEVIRI) combination has been successfully attempted in children with recurrent LGGs, in most cases not previously irradiated. The efficacy of bevacizumab has also been described in radiation necrosis. Considering the possible overlapping of radiation treatment effect and disease progression and difficulty in differentiating, we report on the use of BEVIRI in a case of a recurrent relapsing low-grade glioma of the pineal region, subjected to multiple neurosurgical interventions, also treated with a carboplatin-etoposide regimen and a radiation course, at present at one-year follow-up showing a stable response, with no adverse events. [ABSTRACT FROM AUTHOR]

Low grade gliomas (LGGs) of pineal region are usually difficult to remove and they frequently relapse or progress after front line chemotherapy. BevacizumabIrinotecan (BEVIRI) combination has been successfully attempted in children with recurrent LGGs, in most cases not previously irradiated. The efficacy of bevacizumab has also been described in radiation necrosis. Considering the possible overlapping of radiation treatment effect and disease progression and difficulty in differentiating, we report on the use of BEVIRI in a case of a recurrent relapsing low-grade glioma of the pineal region, subjected to multiple neurosurgical interventions, also treated with a carboplatin-etoposide regimen and a radiation course, at present at one-year follow-up showing a stable response, with no adverse events. [ABSTRACT FROM AUTHOR]

Work life balance, a significant issue in the healthcare sector, recognizes that individuals are engaged in several tasks in their private and professional lives. Literature highlights the harmful consequences of conflicts between personal and professional life for organizations and workers. This study investigates the prevalence of work life balance problems and presence of psychosocial work factors and analyzes their impact on health complaints in the Portuguese healthcare sector. A cross-sectional study of 640 healthcare professionals was conducted using two data collection instruments: INSAT (Inquérito Saúde e Trabalho), a health and work survey to assess psychosocial work factors, and the Portuguese version of the Nottingham Health Profile that evaluates the subjective physical, emotional, and social aspects of health. The data show that healthcare professionals have a very high prevalence of work life balance problems and are exposed to several psychosocial risk factors including high demands and work intensity, working hours, emotional demands, and work characteristics. These experiences are related to professionals' health revealing a state of emotional vulnerability. Thus, Portuguese health organizations should formulate appropriate workplace policy to reduce work life conflict and enable employees to be more effective in their work and other roles. [ABSTRACT FROM AUTHOR]

Background: Positive mental health has had different definitions, but the current one embraces the presence of levels of well-being and decreased levels of psychopathology. This vision of positive mental health has increased the interest in developing positive psychological intervention programs and activities that promote mental health, increasing levels of well- being and decreasing levels of psychopathology. This study aimed to verify the impact and effectiveness of a positive psychotherapybased group intervention plan, in a non-clinical sample on the increase of well-being and reduction of psychopathology. Method: The sample was selected by non-random convenience, consisting of 40 participants, who were subdivided into an experimental group and a comparison group, each consisting of 20 elements. The experimental group is made up by 11 men (55%) and 9 women (45%), with ages between 18- 27 years old, being the average of ages 20,70 (SD= 2,830). The comparison group is composed by 10 women (50%) and 10 men (50%) aged between 18 and 27 years old, being the average of the ages 22 (SD=6,808). To evaluate the effectiveness of the program, an assessment was done in two moments (pre and posttest), using the MHC-SF (for well-being assessment) and the DASS-21 (for psychopathology assessment) as assessment measures. Results: The results obtained show a significant improvement in social well-being as well as a reduction in the levels of psychopathology (anxiety, depression, and stress). Conclusions: These results demonstrate that participation in the program is beneficial for mental health promotion. It is suggested that a larger sample size and a randomization process may be used in future research. [ABSTRACT FROM AUTHOR]

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