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1,121 results on '"Fontana, Angelo"'

1. The NEREA Augmented Observatory: an integrative approach to marine coastal ecology

Author

Campese, Lucia, Russo, Luca, Abagnale, Maria, Alberti, Adriana, Bachi, Giancarlo, Balestra, Cecilia, Bellardini, Daniele, Buondonno, Angela, Cardini, Ulisse, Carotenuto, Ylenia, Checcucci, Giovanni, Chiusano, Maria Luisa, D’Ambra, Isabella, d’Ippolito, Giuliana, Di Capua, Iole, Donnarumma, Vincenzo, Fontana, Angelo, Furia, Marta, Galarza-Verkovitch, Denisse, Gallia, Roberto, Labadie, Karine, Leone, Serena, Licandro, Priscilla, Longo, Antonio, Maselli, Maira, Merquiol, Louise, Murano, Carola, Oliveira, Pedro H., Passarelli, Augusto, Percopo, Isabella, Perdereau, Aude, Piredda, Roberta, Raffini, Francesca, Roncalli, Vittoria, Ruscheweyh, Hans-Joachim, Russo, Ennio, Saggiomo, Maria, Santinelli, Chiara, Sarno, Diana, Sunagawa, Shinichi, Tramontano, Ferdinando, Trano, Anna Chiara, Uttieri, Marco, Wincker, Patrick, Zampicinini, Gianpaolo, Casotti, Raffaella, Conversano, Fabio, D’Alelio, Domenico, Iudicone, Daniele, Margiotta, Francesca, and Montresor, Marina

Published
2024
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11. Potential of Polar Lipids Isolated from the Marine Sponge Haliclona (Halichoclona) vansoesti against Melanoma.

Author

Ruocco, Nadia, Nuzzo, Genoveffa, Federico, Serena, Esposito, Roberta, Gallo, Carmela, Ziaco, Marcello, Manzo, Emiliano, Fontana, Angelo, Bertolino, Marco, Zagami, Giacomo, Zupo, Valerio, Sansone, Clementina, and Costantini, Maria

Subjects
DEATH receptors, SPONGES (Invertebrates), TUMOR necrosis factor receptors, MELANOMA, NUCLEAR magnetic resonance, LIPIDS
Abstract

Marine sponges represent a good source of natural metabolites for biotechnological applications in the pharmacological, cosmeceutical, and nutraceutical fields. In the present work, we analyzed the biotechnological potential of the alien species Haliclona (Halichoclona) vansoesti de Weerdt, de Kluijver & Gomez, 1999, previously collected in the Mediterranean Sea (Faro Lake, Sicily). The bioactivity and chemical content of this species has never been investigated, and information in the literature on its Caribbean counterpart is scarce. We show that an enriched extract of H. vansoesti induced cell death in human melanoma cells with an IC50 value of 36.36 µg mL−1, by (i) triggering a pro-inflammatory response, (ii) activating extrinsic apoptosis mediated by tumor necrosis factor receptors triggering the mitochondrial apoptosis via the involvement of Bcl-2 proteins and caspase 9, and (iii) inducing a significant reduction in several proteins promoting human angiogenesis. Through orthogonal SPE fractionations, we identified two active sphingoid-based lipid classes, also characterized by nuclear magnetic resonance and mass spectrometry, as the main components of two active fractions. Overall, our findings provide the first evaluation of the anti-cancer potential of polar lipids isolated from the marine sponge H. (Halichoclona) vansoesti, which may lead to new lead compounds with biotechnological applications in the pharmaceutical field. [ABSTRACT FROM AUTHOR]

Published
2024
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12. BODIPY-Based Analogue of the TREM2-Binding Molecular Adjuvant Sulfavant A, a Chemical Tool for Imaging and Tracking Biological Systems

Author

Fioretto, Laura, primary, Gallo, Carmela, additional, Mercogliano, Marcello, additional, Ziaco, Marcello, additional, Nuzzo, Genoveffa, additional, d’Ippolito, Giuliana, additional, Follero, Olimpia, additional, DellaGreca, Marina, additional, Giaccio, Paolo, additional, Nittoli, Valeria, additional, Ambrosino, Concetta, additional, Sordino, Paolo, additional, Soluri, Alessandro, additional, Soluri, Andrea, additional, Massari, Roberto, additional, D’Amelio, Marcello, additional, De Palma, Raffaele, additional, Fontana, Angelo, additional, and Manzo, Emiliano, additional

Published
2024
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13. Chemical and Pharmacological Prospection of the Ascidian Cystodytes dellechiajei

Author

Batista, Pedro Jatai, primary, Nuzzo, Genoveffa, additional, Gallo, Carmela, additional, Carbone, Dalila, additional, dell’Isola, Mario, additional, Affuso, Mario, additional, Barra, Giusi, additional, Albiani, Federica, additional, Crocetta, Fabio, additional, Virgili, Riccardo, additional, Mazzella, Valerio, additional, Castiglia, Daniela, additional, d’Ippolito, Giuliana, additional, Manzo, Emiliano, additional, and Fontana, Angelo, additional

Published
2024
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21. The different behaviour of Thermotoga neapolitana in the anodic and cathodic compartment of a bioelectrochemical system

Author

Cristiani Pierangela, Malavola Laura, Franz Silvia, Bestetti Massimiliano, D’Ippolito Giuliana, Esercizio Nunzia, Lanzilli Mariamichela, and Fontana Angelo

Subjects
Environmental sciences, GE1-350
Abstract

Thermotoga neapolitana is a hyperthermophilic bacterium that can metabolize glucose and several organic wastes in hydrogen and lactate at a temperature of 80°C. Their high performance in producing hydrogen at so high a temperature as 80°C suggests a potential energy application of them where hydrogen is an important element of the process. In this view, experimentation of a T.neapolitana strain is carried out in double-chamber electrochemical systems. The aim is to explore the interaction of these bacteria with the anode and the cathode, stressing their capability to survive in presence of a polarized electrode which can drastically change the pH of the media. A culture enriched of 5 g/L of glucose, under CO2 pressure (80 °C) was used to fill both the anodic and cathodic compartments of the electrochemical system, applying a voltage of 1.5 V between the anode and the cathode. The test lasted ten days. Results clearly indicate that bacteria colonize both electrodes, but the glucose metabolism is completely inhibited in the anodic compartments. On the contrary, metabolism is stimulated in the cathodic compartment. Bacteria are alive on the electrodes in the pH interval of 3 - 9.

Published
2022
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30. Corrigendum to “Discovery of lead natural products for developing pan-SARS-CoV-2 therapeutics” “Antiviral Research 209 (2023)/105484”

Author

Perez-Vargas, Jimena, primary, Shapira, Tirosh, additional, Olmstead, Andrea D., additional, Villanueva, Ivan, additional, Thompson, Connor A.H., additional, Ennis, Siobhan, additional, Gao, Guang, additional, De Guzman, Joshua, additional, Williams, David E., additional, Wang, Meng, additional, Chin, Aaleigha, additional, Bautista-Sanchez, Diana, additional, Agafitei, Olga, additional, Levett, Paul, additional, Xie, Xuping, additional, Nuzzo, Genoveffa, additional, Freire, Vitor F., additional, Quintana-Bulla, Jairo I., additional, Bernardi, Darlon I., additional, Gubiani, Juliana R., additional, Suthiphasilp, Virayu, additional, Raksat, Achara, additional, Meesakul, Pornphimol, additional, Polbuppha, Isaraporn, additional, Cheenpracha, Sarot, additional, Jaidee, Wuttichai, additional, Kanokmedhakul, Kwanjai, additional, Yenjai, Chavi, additional, Chaiyosang, Boonyanoot, additional, Teles, Helder Lopes, additional, Manzo, Emiliano, additional, Fontana, Angelo, additional, Leduc, Richard, additional, Boudreault, Pierre-Luc, additional, Berlinck, Roberto G.S., additional, Laphookhieo, Surat, additional, Kanokmedhakul, Somdej, additional, Tietjen, Ian, additional, Cherkasov, Artem, additional, Krajden, Mel, additional, Nabi, Ivan Robert, additional, Niikura, Masahiro, additional, Shi, Pei-Yong, additional, Andersen, Raymond J., additional, and Jean, François, additional

Published
2023
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31. Skeletonema marinoi Extracts and Associated Carotenoid Fucoxanthin Downregulate Pro-Angiogenic Mediators on Prostate Cancer and Endothelial Cells

Author

Calabrone, Luana, primary, Carlini, Valentina, additional, Noonan, Douglas M., additional, Festa, Marco, additional, Ferrario, Cinzia, additional, Morelli, Danilo, additional, Macis, Debora, additional, Fontana, Angelo, additional, Pistelli, Luigi, additional, Brunet, Christophe, additional, Sansone, Clementina, additional, and Albini, Adriana, additional

Published
2023
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37. Organic extract of Geodia cydonium induces cell cycle block in human mesothelioma cells

Author

Di Meo, Francesco, Esposito, Roberta, Cuciniello, Rossana, Favale, Gregorio, Arenga, Mario, Ruocco, Nadia, Nuzzo, Genoveffa, Fontana, Angelo, Filosa, Stefania, Crispi, Stefania, Costantini, Maria, Di Meo, Francesco, Esposito, Roberta, Cuciniello, Rossana, Favale, Gregorio, Arenga, Mario, Ruocco, Nadia, Nuzzo, Genoveffa, Fontana, Angelo, Filosa, Stefania, Crispi, Stefania, and Costantini, Maria

Subjects
Cancer Research, antiproliferative effect, Oncology, mesothelioma, Geodia cydonium extract, solid-phase extraction, cell cycle block
Abstract

The serious side effects caused by chemotherapeutics and the development of cancer chemoresistance represent the most significant limitations in the treatment of cancer. Some alternative approaches have been developed in recent years, which are based on natural compounds, and have allowed important advances in cancer therapeutics. During the last 50 years, sponges have been considered a promising source of natural products from the marine environment, representing ~30% of all marine natural products. Among sponges, the Mediterranean species Geodia cydonium represents a potential source of these type of products with considerable biotechnological interest as pharmaceutical agents. The present study demonstrated the antiproliferative effect of an organic G. cydonium extract (GEOCYDO) against three human mesothelioma cell lines, MSTO-211H (MSTO), NCI-H2452 (NCI) and Ist-Mes2 (Mes2), which differ in their sensitivity (MSTO and NCI) and resistance (Mes2) to standard combined treatment with cisplatin and piroxicam. To this aim, the activity of the extract was evaluated by analyzing its effects on cell viability, cancer properties and cell cycle progression by means of colony formation assay, cell cycle analysis and protein expression analysis. The results revealed, in mesothelioma, this extract was able to reduce self-renewal, cell migration and it could induce cell cycle arrest in G0/G1 stage, thus blocking cell proliferation. In conclusion, to the best of our knowledge, the present results indicated for the first time that GEOCYDO can contain active compounds able to affect cell proliferation in mesothelioma, suggesting that it could be considered as a potential novel drug source for cancer treatment.

Published
2022

38. The immunoregulatory effect of the TREM2-agonist Sulfavant A in human allogeneic mixed lymphocyte reaction

Author

Barra, Giusi, primary, Gallo, Carmela, additional, Carbone, Dalila, additional, Ziaco, Marcello, additional, Dell’Isola, Mario, additional, Affuso, Mario, additional, Manzo, Emiliano, additional, Nuzzo, Genoveffa, additional, Fioretto, Laura, additional, D’Ippolito, Giuliana, additional, De Palma, Raffaele, additional, and Fontana, Angelo, additional

Published
2023
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40. Discovery of lead natural products for developing pan-SARS-CoV-2 therapeutics

Author

Pérez-Vargas, Jimena, primary, Shapira, Tirosh, additional, Olmstead, Andrea D., additional, Villanueva, Ivan, additional, Thompson, Connor A.H., additional, Ennis, Siobhan, additional, Gao, Guang, additional, De Guzman, Joshua, additional, Williams, David E., additional, Wang, Meng, additional, Chin, Aaleigha, additional, Bautista-Sánchez, Diana, additional, Agafitei, Olga, additional, Levett, Paul, additional, Xie, Xuping, additional, Nuzzo, Genoveffa, additional, Freire, Vitor F., additional, Quintana-Bulla, Jairo I., additional, Bernardi, Darlon I., additional, Gubiani, Juliana R., additional, Suthiphasilp, Virayu, additional, Raksat, Achara, additional, Meesakul, Pornphimol, additional, Polbuppha, Isaraporn, additional, Cheenpracha, Sarot, additional, Jaidee, Wuttichai, additional, Kanokmedhakul, Kwanjai, additional, Yenjai, Chavi, additional, Chaiyosang, Boonyanoot, additional, Teles, Helder Lopes, additional, Manzo, Emiliano, additional, Fontana, Angelo, additional, Leduc, Richard, additional, Boudreault, Pierre-Luc, additional, Berlinck, Roberto G.S., additional, Laphookhieo, Surat, additional, Kanokmedhakul, Somdej, additional, Tietjen, Ian, additional, Cherkasov, Artem, additional, Krajden, Mel, additional, Nabi, Ivan Robert, additional, Niikura, Masahiro, additional, Shi, Pei-Yong, additional, Andersen, Raymond J., additional, and Jean, François, additional

Published
2023
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42. Formation and inactivation of endogenous cannabinoid anandamide in central neurons

Author

Di Marzo, Vincenzo, Fontana, Angelo, Cadas, Hugues, Schinelli, Sergio, Cimino, Guido, Schwartz, Jean-Charles, and Piomelli, Danlele

Subjects
Drug Abuse (NIDA only), Substance Misuse, Neurosciences, 1.1 Normal biological development and functioning, Underpinning research, Neurological, Animals, Arachidonic Acids, Astrocytes, Cannabinoids, Cells, Cultured, Central Nervous System, Cerebral Cortex, Corpus Striatum, Endocannabinoids, Ionomycin, Neurons, Phosphatidylethanolamines, Polyunsaturated Alkamides, Rats, Signal Transduction, General Science & Technology
Abstract

Anandamide (N-arachidonoyl-ethanolamine) was recently identified as a brain arachidonate derivative that binds to and activates cannabinoid receptors, yet the mechanisms underlying formation, release and inactivation of this putative messenger molecule are still unclear. Here we report that anandamide is produced in and released from cultured brain neurons in a calcium ion-dependent manner when the neurons are stimulated with membrane-depolarizing agents. Anandamide formation occurs through phosphodiesterase-mediated cleavage of a novel phospholipid precursor, N-arachidonoyl-phosphatidylethanolamine. A similar mechanism also governs the formation of a family of anandamide congeners, whose possible roles in neuronal signalling remain unknown. Our results and those of others indicate therefore that multiple biochemical pathways may participate in anandamide formation in brain tissue. The life span of extracellular anandamide is limited by a rapid and selective process of cellular uptake, which is accompanied by hydrolytic degradation to ethanolamine and arachidonate. Our results thus strongly support the proposed role of anandamide as an endogenous neuronal messenger.

Published
1994

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