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1. Key Role for Respiratory CD103⁺ Dendritic Cells, IFN-γ, and IL-17 in Protection Against Streptococcus pneumoniae Infection in Response to α-Galactosylceramide

Author

Ivanov, Stoyan, Fontaine, Josette, Paget, Christophe, Fernandez, Elodie Macho, Van Maele, Laurye, Renneson, Joelle, Maillet, Isabelle, Wolf, Natalia Muñoz, Rial, Analia, Léger, Hélène, Ryffel, Bernard, Frisch, Benoit, Chabalgoity, José A., Sirard, Jean Claude, Benecke, Arndt, Faveeuw, Christelle, and Trottein, François

Published
2012
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7. Alteration of Flt3-Ligand-dependent de novo generation of conventional dendritic cells during influenza infection contributes to respiratory bacterial superinfection

Author

Beshara, Ranin, Sencio, Valentin, Soulard, Daphnée, Barthélémy, Adeline, Fontaine, Josette, Pinteau, Thibault, Deruyter, Lucie, Ismail, Mohamad Bachar, Paget, Christophe, Sirard, Jean-Claude, Trottein, François, Faveeuw, Christelle, Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 (CIIL), Centre National de la Recherche Scientifique (CNRS)-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Université de Lille-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Laboratoire Santé Environnement et Microbiologie (LSEM), Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER), Ecole Doctorale des Sciences et de la Technologie (EDST), Lebanese University [Beirut] (LU), Université Libanaise, Laboratoire Microbiologie Santé et Environnement - LMSE [Tripoli, Lebanon] (Faculté de Santé Publique), Université Libanaise-Ecole Doctorale des Sciences et de Technologie [Tripoli, Lebanon], This work was supported by Inserm, CNRS, University of Lille, l’Institut Pasteur de Lilleand grants from the région des Hauts-de-France and the state of Minais Gerais/FAPEMIG (FrancoBrazilian call 2014-2015, FLUMICROBIOT) and l’Agence Nationale de la Recherche (AAP générique 2017, ANR-17-CE15-0020-01, ACROBAT) and laStructure Fédérative Maladies Infectieuses, Inflammatoires Immunitaires (SF3i – FED 4258)., ANR-17-CE15-0020,ACROBAT,Rôle de l'axe poumon/intestin/moelle osseuse et du microbiote au cours de la grippe(2017), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), Sirard, Jean-Claude, Rôle de l'axe poumon/intestin/moelle osseuse et du microbiote au cours de la grippe - - ACROBAT2017 - ANR-17-CE15-0020 - AAPG2017 - VALID, Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL], Laboratoire Santé Environnement et Microbiologie [LSEM], CHU Lille, Centre d’Etude des Pathologies Respiratoires (CEPR), UMR 1100 (CEPR), and Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
RNA viruses, Male, Viral Diseases, Pulmonology, Physiology, [SDV]Life Sciences [q-bio], Receptor, Interferon alpha-beta, Monocytes, White Blood Cells, Mice, Animal Cells, Immune Physiology, Biology (General), Immune Response, Lung, Pathology and laboratory medicine, Cells, Cultured, ComputingMilieux_MISCELLANEOUS, Mice, Knockout, Innate Immune System, Cell Differentiation, Medical microbiology, Body Fluids, [SDV] Life Sciences [q-bio], Infectious Diseases, Blood, Streptococcus pneumoniae, Influenza A virus, Viruses, Cytokines, [SDV.IMM]Life Sciences [q-bio]/Immunology, Pathogens, Cellular Types, Anatomy, Research Article, [SDV.IMM] Life Sciences [q-bio]/Immunology, QH301-705.5, Immune Cells, Immunology, Microbiology, Pneumococcal Infections, Signs and Symptoms, Orthomyxoviridae Infections, Diagnostic Medicine, Influenza viruses, Animals, Medicine and health sciences, Inflammation, Blood Cells, Biology and life sciences, Organisms, Viral pathogens, Membrane Proteins, Cell Biology, Dendritic Cells, RC581-607, Molecular Development, Influenza, Microbial pathogens, Mice, Inbred C57BL, Immune System, Superinfection, Respiratory Infections, Immunologic diseases. Allergy, Orthomyxoviruses, Developmental Biology
Abstract

Secondary bacterial infections contribute to the excess morbidity and mortality of influenza A virus (IAV) infection. Disruption of lung integrity and impaired antibacterial immunity during IAV infection participate in colonization and dissemination of the bacteria out of the lungs. One key feature of IAV infection is the profound alteration of lung myeloid cells, characterized by the recruitment of deleterious inflammatory monocytes. We herein report that IAV infection causes a transient decrease of lung conventional dendritic cells (cDCs) (both cDC1 and cDC2) peaking at day 7 post-infection. While triggering emergency monopoiesis, IAV transiently altered the differentiation of cDCs in the bone marrow, the cDC1-biaised pre-DCs being particularly affected. The impaired cDC differentiation during IAV infection was independent of type I interferons (IFNs), IFN-γ, TNFα and IL-6 and was not due to an intrinsic dysfunction of cDC precursors. The alteration of cDC differentiation was associated with a drop of local and systemic production of Fms-like tyrosine kinase 3 ligand (Flt3-L), a critical cDC differentiation factor. Overexpression of Flt3-L during IAV infection boosted the cDC progenitors’ production in the BM, replenished cDCs in the lungs, decreased inflammatory monocytes’ infiltration and lowered lung damages. This was associated with partial protection against secondary pneumococcal infection, as reflected by reduced bacterial dissemination and prolonged survival. These findings highlight the impact of distal viral infection on cDC genesis in the BM and suggest that Flt3-L may have potential applications in the control of secondary infections., Author summary Secondary bacterial infections constitute a leading cause of mortality during influenza epidemics and pandemics. Acute infections trigger the mobilization of myeloid cells from the bone marrow (BM) to the infected tissues, a process referred to as emergency myelopoiesis. Influenza infection leads to a profound alteration in the pulmonary myeloid cell compartment characterized by the recruitment of inflammatory myeloid cells. The consequences of IAV infection on BM myelopoiesis have yet to be described in detail. Here, we report that influenza infection leads to reduced number of conventional dendritic cells (cDC) in the lungs (with a peak at day 7) and severely impairs DC differentiation in the BM, for the benefit of monopoiesis. The altered cDC differentiation was independent of pro-inflammatory cytokines and was not due to an intrinsic dysfunction of cDC precursors. Defective DC differentiation during influenza was associated with a decrease in the production of the key cDC differentiation factor, Fms-like tyrosine kinase 3 ligand (Flt3-L). Overexpression of Flt3-L during influenza enhanced the number of BM cDC progenitors and restored lung cDC compartment. This phenomenon was associated with a lowered number of lung inflammatory monocytes and reduced lung damages. Importantly, Flt3-L overexpression partially protected against secondary pneumococcal infection characterized by reduced bacterial loads, improved pathological outcomes and prolonged survival. Our results provide new clues as to how influenza infection influences the differentiation of cDCs, and highlight the potential therapeutic value of Flt3-L in a disease in desperate need of better treatments.

Published
2018

12. Co-delivery of the NKT agonist α-galactosylceramide and tumor antigens to cross-priming dendritic cells breaks tolerance to self-antigens and promotes antitumor responses

Author

Ghinnagow, Reem, primary, De Meester, Julie, additional, Cruz, Luis Javier, additional, Aspord, Caroline, additional, Corgnac, Stéphanie, additional, Macho-Fernandez, Elodie, additional, Soulard, Daphnée, additional, Fontaine, Josette, additional, Chaperot, Laurence, additional, Charles, Julie, additional, Soncin, Fabrice, additional, Mami-Chouaib, Fathia, additional, Plumas, Joel, additional, Faveeuw, Christelle, additional, and Trottein, François, additional

Published
2017
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14. Crystal structure of the 28 kDA glutathione S-transferase from Schistosoma haematobium

Author

Johnson, Kenneth a., Angelucci, Francesco, Bellelli, Andrea, Herve, Maxime, Fontaine, Josette, Tsernoglou, Demetrious, Capron, Andre, Trottein, Francois, and Brunori, Maurizio

Subjects
Transferases, Structure-activity relationships (Biochemistry) -- Analysis, Host-parasite relationships -- Physiological aspects, Schistosomiasis -- Physiological aspects, Biological sciences, Chemistry
Abstract

Crystal structure of the glutathione S-transferase, with or without glutathione from Schistosoma haematobium is described. It is a 28 kilodalton multifunctional enzyme involved in host-parasite relationships. Data indicate that glutathione is a tightly bound cofactor and mediates the catalytic mechanism for prostaglandin D(sub)2 synthase activity.

Published
2003

17. Toll-like receptor (TLR)2 and TLR3 synergy and cross-inhibition in murine myeloid dendritic cells.

Author

Vanhoutte, François, Paget, Christophe, Breuilh, Laetitia, Fontaine, Josette, Vendeville, Catherine, Goriely, Stanislas, Ryffel, Bernard, Faveeuw, Christelle, Trottein, François, Vanhoutte, François, Paget, Christophe, Breuilh, Laetitia, Fontaine, Josette, Vendeville, Catherine, Goriely, Stanislas, Ryffel, Bernard, Faveeuw, Christelle, and Trottein, François

Abstract

Toll-like receptors (TLRs) play an important role in the innate recognition of pathogens by dendritic cells (DCs) and in the induction of immune responses. Few studies have been devoted to address the impact of TLR2 (a fully MyD88-dependent receptor) and TLR3 (a fully TRIF-dependent receptor) co-activation on DC functions, especially in the mouse system. Using canonical agonists, we show that TLR2 acts in concert with TLR3 to induce the synthesis of inflammatory cytokines (TNF-alpha, IL-6), of some IL-12 family members (IL-12p40, IL-12p23, IL-27p28) and of the Notch ligand Delta-4 by mouse DCs. In contrast, TLR2 interferes with the TLR3-induced expression of type I interferon stimulated genes (MIG/CXCL9, IP-10/CXCL10, GARG39) and IL-12p35. We also report that TLR2 cooperates with TLR3 to enhance the DC-mediated production of IFN-gamma by Natural Killer cells and by conventional Ag-specific T lymphocytes. To conclude, our data support the existence of TLR2 and TLR3 synergy and cross-inhibition in DCs that could be important to strengthen immune responses during infection., Journal Article, Research Support, Non-U.S. Gov't, info:eu-repo/semantics/published

Published
2008

18. Prostaglandin D2 inhibits the production of IFN-gamma by invariant NK T cells: consequences in the control of B16 melanoma.

Author

Torres, David, Paget, Christophe, Fontaine, Josette, Mallevaey, Thierry, Matsuoka, Toshiyuki, Maruyama, Tatsuya, Narumiya, Shuh, Capron, Monique, Gosset, Philippe, Faveeuw, Christelle, Trottein, François, Torres, David, Paget, Christophe, Fontaine, Josette, Mallevaey, Thierry, Matsuoka, Toshiyuki, Maruyama, Tatsuya, Narumiya, Shuh, Capron, Monique, Gosset, Philippe, Faveeuw, Christelle, and Trottein, François

Abstract

Invariant NK T (iNKT) cells are a subset of innate/memory lymphocytes that recognize lipid Ags presented by CD1d-expressing APCs such as dendritic cells (DCs). Upon primary stimulation through their TCR, iNKT cells promptly produce large amounts of IFN-gamma and/or IL-4 that play critical roles in the regulation of innate and adaptive immune responses. To date, the role of environmental factors on iNKT cell functions has been poorly investigated. In this study, we addressed the question of whether PGD2, a potent eicosanoid lipid mediator involved in immune responses and inflammation, could be important in DC/iNKT cell cross-talk. We show that PGD2 dramatically reduced the production of IFN-gamma, but not IL-4, by iNKT cells in response to the superagonist alpha-galactosylceramide (alpha-GalCer) both in vitro and in vivo. This effect is mediated by the D prostanoid receptor 1 (DP1) expressed by DCs and iNKT cells and requires protein kinase A activation. We also report that PGD2 and BW245C (a selective DP1 agonist) reduce the protective effects of alpha-GalCer in B16F10-induced melanoma metastasis, an effect that depends on IFN-gamma production by iNKT cells. As a whole, these data reveal novel pathways regulating iNKT cell biologic functions and confirm the immunoregulatory roles of PGD2 on the innate response., info:eu-repo/semantics/published

Published
2008

19. Relationship of Impairment of Schistosome 28-Kilodalton Glutathione S-Transferase (GST) Activity to Expression of Immunity to Schistosoma mattheei in Calves Vaccinated with Recombinant Schistosoma bovis 28-Kilodalton GST

Author

Grzych, Jean-Marie, De Bont, Jan, Liu, Jinli, Neyrinck, Jean-Loup, Fontaine, Josette, Vercruysse, Jozef, and Capron, André

Subjects
Molecular Weight, Vaccines, Synthetic, Immunoglobulin G, Vaccination, Antibodies, Helminth, Animals, Schistosoma, Cattle, Helminth Proteins, Fungal and Parasitic Infections, Cross Reactions, Glutathione Transferase, Immunoglobulin A
Abstract

Sera from calves vaccinated with the recombinant Schistosoma bovis-derived 28-kDa glutathione S-transferase (28GST) and subsequently naturally or experimentally exposed to Schistosoma mattheei were studied for their content of specific immunoglobulin G (IgG) and IgA antibodies to recombinant S. bovis 28GST as well as for their capacity to inhibit the enzymatic activity of the antigen. The results were analyzed in regard to the presence (natural infection) or absence (experimental infection) of a protective effect(s) (reductions in worm burden, egg load, fecal egg counts, and excretion of viable eggs) toward S. mattheei challenge. Under such conditions, no differences in the IgG- and IgA-specific antibodies to recombinant S. bovis 28GST or in the ability to block the catalytic function of the antigen between the two groups were recorded. Nevertheless, correlation analysis between the specific antibody responses to recombinant S. bovis 28GST and the inhibition of GST activity suggested an association with IgG in experimentally infected vaccinated animals, while in naturally infected vaccinated calves, the inhibitory activity appeared to be linked to a greater degree with IgA. These results suggest that in contrast to schistosomiasis in humans, IgG antibodies in calves with schistosomiasis may exhibit inhibitory functions toward GST enzymatic activity or have a modulatory effect on IgA antibody properties. Furthermore, sera from animals immunized with recombinant S. bovis 28GST recognized the native S. mattheei 28GST and achieved comparable levels of inhibition of activity of recombinant S. bovis 28GST and S. matthei 28GST, indicating the presence of cross-reactive epitopes on these two molecules.

Published
1998

20. Interleukin-22 Reduces Lung Inflammation during Influenza A Virus Infection and Protects against Secondary Bacterial Infection

Author

Ivanov, Stoyan, primary, Renneson, Joelle, additional, Fontaine, Josette, additional, Barthelemy, Adeline, additional, Paget, Christophe, additional, Fernandez, Elodie Macho, additional, Blanc, Fany, additional, De Trez, Carl, additional, Van Maele, Laurye, additional, Dumoutier, Laure, additional, Huerre, Michel-René, additional, Eberl, Gérard, additional, Si-Tahar, Mustapha, additional, Gosset, Pierre, additional, Renauld, Jean Christophe, additional, Sirard, Jean Claude, additional, Faveeuw, Christelle, additional, and Trottein, François, additional

Published
2013
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21. Toll-like receptor (TLR)2 and TLR3 sensing is required for dendritic cell activation, but dispensable to control Schistosoma mansoni infection and pathology.

Author

Vanhoutte, François, Breuilh, Laetitia, Fontaine, Josette, Zouain, Claudia S, Mallevaey, Thierry, Vasseur, Virginie, Capron, Monique, Goriely, Stanislas, Faveeuw, Christelle, Ryffel, Bernard, Trottein, François, Vanhoutte, François, Breuilh, Laetitia, Fontaine, Josette, Zouain, Claudia S, Mallevaey, Thierry, Vasseur, Virginie, Capron, Monique, Goriely, Stanislas, Faveeuw, Christelle, Ryffel, Bernard, and Trottein, François

Abstract

Toll-like receptors (TLRs) play an important role in the innate recognition of pathogens by dendritic cells (DCs) and in the induction of immune responses. However, relatively little is known about their functions in innate/acquired responses to complex eukaryotic microorganisms, including helminth parasites. That Schistosoma mansoni eggs activate myeloid DCs through TLR2 and TLR3 has been shown by us and others, but the consequences of this combined activation are still unknown. We show that the engagement of both TLR2 and TLR3 by schistosome eggs is important for the production of inflammatory cytokines and interferon-stimulated genes, such as some chemokines, by DCs. Strikingly, DCs sensitized with ovalbumin in the presence of parasite eggs dramatically reduce the release of Th2-type cytokines by ovalbumin-specific T lymphocytes, an effect that fully depends on TLR3. Finally, although TLR2 and TLR3 have no role in host resistance and in egg-induced granuloma formation in S. mansoni-infected mice, they individually and additionally increase the Th1/Th2 balance of the immune response. Thus, TLR2 and TLR3 sensing is required to shape the immune response during murine schistosomiasis, but is dispensable to control infection and pathology., Journal Article, Research Support, Non-U.S. Gov't, info:eu-repo/semantics/published

Published
2007

22. Double-stranded RNAs from the helminth parasite Schistosoma activate TLR3 in dendritic cells.

Author

Aksoy, Ezra, Zouain, Claudia S, Vanhoutte, François, Fontaine, Josette, Pavelka, Norman, Thieblemont, Nathalie, Willems, Fabienne, Ricciardi-Castagnoli, Paola, Goldman, Michel, Capron, Monique, Ryffel, Bernard, Trottein, François, Aksoy, Ezra, Zouain, Claudia S, Vanhoutte, François, Fontaine, Josette, Pavelka, Norman, Thieblemont, Nathalie, Willems, Fabienne, Ricciardi-Castagnoli, Paola, Goldman, Michel, Capron, Monique, Ryffel, Bernard, and Trottein, François

Abstract

Stimulation of dendritic cells (DCs) by the egg stage of the helminth parasite Schistosoma mansoni activates a signaling pathway resulting in type I interferon (IFN) and IFN-stimulated gene (ISG) expression. Here, we demonstrate that S. mansoni eggs disjointedly activate myeloid differentiation factor 88 (MyD88)-dependent and MyD88-independent pathways in DCs. Inflammatory cytokine expression and NF-kappa B activation in DCs from MyD88-deficient mice were impaired, whereas signaling transducer activator of transcription (STAT) 1(Tyr701) phosphorylation and ISG expression were intact in MyD88 or Toll-like receptor (TLR)4-deficient counterparts. Accordingly, we analyzed distinct TLR members for their ability to respond to schistosome eggs and established that TLR3 resulted in the activation of NF-kappa B and the positive regulatory domain III-I site from IFN-beta promoter. Unexpectedly, egg-derived RNA possessed RNase A-resistant and RNase III-sensitive structures capable of triggering TLR3 activation, suggesting the involvement of double-stranded (ds) structures. Moreover, DCs from TLR3-deficient mice displayed a complete loss of signaling transducer activator of transcription 1 phosphorylation and ISG expression in response to egg-derived dsRNA. Finally, TLR3-deficient DCs showed a reduced response to schistosome eggs relative to wild-type cells. Collectively, our data suggest for the first time that dsRNA from a non-viral pathogen may act as an inducer of the innate immune system through TLR3., Journal Article, Research Support, Non-U.S. Gov't, info:eu-repo/semantics/published

Published
2005

23. Interleukin-22 Is Produced by Invariant Natural Killer T Lymphocytes during Influenza A Virus Infection

Author

Paget, Christophe, primary, Ivanov, Stoyan, additional, Fontaine, Josette, additional, Renneson, Joelle, additional, Blanc, Fany, additional, Pichavant, Muriel, additional, Dumoutier, Laure, additional, Ryffel, Bernhard, additional, Renauld, Jean Christophe, additional, Gosset, Philippe, additional, Gosset, Pierre, additional, Si-Tahar, Mustapha, additional, Faveeuw, Christelle, additional, and Trottein, François, additional

Published
2012
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24. Activation of invariant Natural Killer T lymphocytes in response to the α-galactosylceramide analogue KRN7000 encapsulated in PLGA-based nanoparticles and microparticles

Author

Macho Fernandez, Elodie, primary, Chang, Jiang, additional, Fontaine, Josette, additional, Bialecki, Emilie, additional, Rodriguez, Fabien, additional, Werkmeister, Elisabeth, additional, Krieger, Vanessa, additional, Ehret, Christophe, additional, Heurtault, Béatrice, additional, Fournel, Sylvie, additional, Frisch, Benoit, additional, Betbeder, Didier, additional, Faveeuw, Christelle, additional, and Trottein, François, additional

Published
2012
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25. Spleen-Resident CD4+ and CD4− CD8α− Dendritic Cell Subsets Differ in Their Ability to Prime Invariant Natural Killer T Lymphocytes

Author

Bialecki, Emilie, primary, Macho Fernandez, Elodie, additional, Ivanov, Stoyan, additional, Paget, Christophe, additional, Fontaine, Josette, additional, Rodriguez, Fabien, additional, Lebeau, Luc, additional, Ehret, Christophe, additional, Frisch, Benoit, additional, Trottein, François, additional, and Faveeuw, Christelle, additional

Published
2011
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26. Correction: Potential Role of Invariant NKT Cells in the Control of Pulmonary Inflammation and CD8+ T Cell Response during Acute Influenza A Virus H3N2 Pneumonia

Author

Paget, Christophe, primary, Ivanov, Stoyan, additional, Fontaine, Josette, additional, Blanc, Fany, additional, Pichavant, Muriel, additional, Renneson, Joelle, additional, Bialecki,, Emilie, additional, Pothlichet, Julien, additional, Vendeville, Catherine, additional, Barba-Speath, Giovanna, additional, Huerre, Michel-René, additional, Faveeuw, Christelle, additional, Si-Tahar, Mustapha, additional, and Trottein, François, additional

Published
2011
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27. Potential Role of Invariant NKT Cells in the Control of Pulmonary Inflammation and CD8+ T Cell Response during Acute Influenza A Virus H3N2 Pneumonia

Author

Paget, Christophe, primary, Ivanov, Stoyan, additional, Fontaine, Josette, additional, Blanc, Fany, additional, Pichavant, Muriel, additional, Renneson, Joelle, additional, Bialecki, Emilie, additional, Pothlichet, Julien, additional, Vendeville, Catherine, additional, Barba-Speath, Giovanna, additional, Huerre, Michel-René, additional, Faveeuw, Christelle, additional, Si-Tahar, Mustapha, additional, and Trottein, François, additional

Published
2011
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28. Antigen presentation by CD1d contributes to the amplification of Th2 responses to Schistosoma mansoni glycoconjugates in mice.

Author

Faveeuw, Christelle, Angeli, Véronique, Fontaine, Josette, Maliszewski, Charles, Capron, André, Van Kaer, Luc, Moser, Muriel, Capron, Monique, Trottein, François, Faveeuw, Christelle, Angeli, Véronique, Fontaine, Josette, Maliszewski, Charles, Capron, André, Van Kaer, Luc, Moser, Muriel, Capron, Monique, and Trottein, François

Abstract

During murine schistosomiasis, there is a gradual switch from a predominant Th1 cytokine response to a Th2-dominated response after egg laying, an event that favors the formation of granuloma around viable eggs. Egg-derived glycoconjugates, including glycolipids, may play a crucial role in this phenomenon. In this study, we used a model of dendritic cell sensitization to study the role of egg glycoconjugates in the induction of specific immune response to soluble egg Ag (SEA) and to investigate the possibility that CD1d, a molecule implicated in glycolipid presentation, may be involved in such a phenomenon. We show that, when captured, processed, and presented to naive T lymphocytes by dendritic cells, egg, but not larval, Ag skew the immune response toward a Th2 response. Periodate treatment reversed this effect, indicating that the sugar moiety of SEA is important in this phenomenon. Using DC treated ex vivo with a neutralizing anti-CD1d Ab or isolated from CD1d knockout mice, we show that CD1d is crucial in the priming of SEA-specific Th2 lymphocytes. We then evaluated the contribution of CD1d on the development of the SEA-specific immune response and on the formation of the egg-induced liver granuloma during murine schistosomiasis. We find that CD1d knockout mice have a reduced Th2 response after egg laying and develop a less marked fibrotic pathology compared with wild-type mice. Altogether, our results suggest that Ag presentation of parasite glycoconjugates to CD1d-restricted T cells may be important in the early events leading to the induction of Th2 responses and to egg-induced pathology during murine schistosomiasis., Journal Article, Research Support, Non-U.S. Gov't, info:eu-repo/semantics/published

Published
2002

32. Prostaglandin D2 Inhibits the Production of IFN-γ by Invariant NK T Cells: Consequences in the Control of B16 Melanoma

Author

Torres, David, primary, Paget, Christophe, additional, Fontaine, Josette, additional, Mallevaey, Thierry, additional, Matsuoka, Toshiyuki, additional, Maruyama, Takayuki, additional, Narumiya, Shuh, additional, Capron, Monique, additional, Gosset, Philippe, additional, Faveeuw, Christelle, additional, and Trottein, François, additional

Published
2008
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33. Molecular cloning of a putative alpha3-fucosyltransferase from Schistosoma mansoni

Author

Trottein, François, Mollicone, R, Fontaine, Josette, De Mendonça, Ricardo, Piller, F, Pierce, Raymond, Oriol, R, Capron, Monique, Trottein, François, Mollicone, R, Fontaine, Josette, De Mendonça, Ricardo, Piller, F, Pierce, Raymond, Oriol, R, and Capron, Monique

Abstract

info:eu-repo/semantics/published

Published
2000

34. Toll-like receptor (TLR)2 and TLR3 sensing is required for dendritic cell activation, but dispensable to control Schistosoma mansoni infection and pathology

Author

Vanhoutte, François, primary, Breuilh, Laetitia, additional, Fontaine, Josette, additional, Zouain, Claudia S., additional, Mallevaey, Thierry, additional, Vasseur, Virginie, additional, Capron, Monique, additional, Goriely, Stanislas, additional, Faveeuw, Christelle, additional, Ryffel, Bernhard, additional, and Trottein, François, additional

Published
2007
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35. Galectin-3 Modulates Immune and Inflammatory Responses during Helminthic Infection: Impact of Galectin-3 Deficiency on the Functions of Dendritic Cells

Author

Breuilh, Laetitia, primary, Vanhoutte, François, additional, Fontaine, Josette, additional, van Stijn, Caroline M. W., additional, Tillie-Leblond, Isabelle, additional, Capron, Monique, additional, Faveeuw, Christelle, additional, Jouault, Thierry, additional, van Die, Irma, additional, Gosset, Philippe, additional, and Trottein, François, additional

Published
2007
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36. Invariant and Noninvariant Natural Killer T Cells Exert Opposite Regulatory Functions on the Immune Response during Murine Schistosomiasis

Author

Mallevaey, Thierry, primary, Fontaine, Josette, additional, Breuilh, Laetitia, additional, Paget, Christophe, additional, Castro-Keller, Alexandre, additional, Vendeville, Catherine, additional, Capron, Monique, additional, Leite-de-Moraes, Maria, additional, Trottein, François, additional, and Faveeuw, Christelle, additional

Published
2007
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39. Double-stranded RNAs from the Helminth Parasite Schistosoma Activate TLR3 in Dendritic Cells

Author

Aksoy, Ezra, primary, Zouain, Claudia S., additional, Vanhoutte, François, additional, Fontaine, Josette, additional, Pavelka, Norman, additional, Thieblemont, Nathalie, additional, Willems, Fabienne, additional, Ricciardi-Castagnoli, Paola, additional, Goldman, Michel, additional, Capron, Monique, additional, Ryffel, Bernard, additional, and Trottein, François, additional

Published
2005
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41. Schistosome N-glycans containing core α3-fucose and core β2-xylose epitopes are strong inducers of Th2 responses in mice

Author

Faveeuw, Christelle, primary, Mallevaey, Thierry, additional, Paschinger, Katharina, additional, Wilson, Iain B. H., additional, Fontaine, Josette, additional, Mollicone, Rosella, additional, Oriol, Rafael, additional, Altmann, Friedrich, additional, Lerouge, Patrice, additional, Capron, Monique, additional, and Trottein, François, additional

Published
2003
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50. Expression of a Schistosoma mansoni 28-Kilodalton Glutathione S -Transferase in the Livers of Transgenic Mice and Its Effect on Parasite Infection

Author

Xu, Xiaochuan, primary, Lemaire, Catherine, additional, Grzych, Jean-Marie, additional, Pierce, Raymond J., additional, Raccurt, Mireille, additional, Mullier, Frederic, additional, Zerimech, Farid, additional, Decavel, Jean-Pierre, additional, Peyrol, Simone, additional, Liu, Jinli, additional, Fontaine, Josette, additional, Lafitte, Sophia, additional, Capron, André, additional, and Cesbron, Jean-Yves, additional

Published
1998
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