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3. Manejo do risco cardiovascular: dislipidemia

Author

Izar, Maria Cristina de Oliveira, primary, Fonseca, Francisco Antonio Helfenstein, additional, Faludi, André Árpád, additional, Araújo, Daniel Branco de, additional, Valente, Fernando, additional, and Bertoluci, Marcello, additional

Published
2022
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4. Manejo da hipertensão arterial no diabetes

Author

Izar, Maria Cristina de Oliveira, primary, Fonseca, Francisco Antonio Helfenstein, additional, Faludi, André Árpád, additional, Araújo, Daniel Branco de, additional, and Bertoluci, Marcello, additional

Published
2022
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5. Evaluation of two highly effective lipid-lowering therapies in subjects with acute myocardial infarction

Author

Klassen, Aline, Faccio, Andrea Tedesco, Picossi, Carolina Raissa Costa, Derogis, Priscilla Bento Matos Cruz, dos Santos Ferreira, Carlos Eduardo, Lopes, Aline Soriano, Sussulini, Alessandra, Cruz, Elisa Castañeda Santa, Bastos, Rafaela Tudela, Fontoura, Stefanie Caroline, Neto, Antonio Martins Figueiredo, Tavares, Marina Franco Maggi, Izar, Maria Cristina, and Fonseca, Francisco Antonio Helfenstein

Published
2021
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6. Manejo do risco cardiovascular: dislipidemia

Author

Izar, Maria Cristina de Oliveira, primary, Fonseca, Francisco Antonio Helfenstein, additional, Faludi, André Árpád, additional, Araújo, Daniel Branco de, additional, Valente, Fernando, additional, and Bertoluci, Marcello Casaccia, additional

Published
2021
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9. Persistence of a proinflammatory status after treatment of the acute myocardial infarction

Author

da Silva, Leandro Santos, primary, Germano, Danielle Borges, additional, Fonseca, Francisco Antonio Helfenstein, additional, Shio, Marina Tiemi, additional, da Silva Nali, Luiz Henrique, additional, Tuleta, Izabela Dorota, additional, Juliano, Yára, additional, de Oliveira Izar, Maria Cristina, additional, Ribeiro, Ana Paula, additional, Kato, Juliana Tieko, additional, do Amaral, Jônatas Bussador, additional, and França, Carolina Nunes, additional

Published
2023
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11. Contributors

Author

Abbott-Johnson, Winsome, primary, Acar, Niyazi, additional, Achiron, Asaf, additional, Agte, Vaishali, additional, Armstrong, R.A., additional, Aydın, Bahri, additional, Bahmani, Fereshteh, additional, Bretillon, Lionel, additional, Bron, Alain M., additional, Burgansky-Eliash, Zvia, additional, Chaubey, Pramila, additional, Čolak, Emina, additional, Cole, Damian, additional, Comaratta, Marc, additional, Cossenza, M., additional, Creuzot-Garcher, Catherine P., additional, Cubbidge, R.C., additional, Cubbidge, R.P., additional, Cutolo, Carlo Alberto, additional, de Koning-Backus, Alexandra P M, additional, de Oliveira Izar, Maria Cristina, additional, de Velasco, Patricia Coelho, additional, Domith, I., additional, Encarnação, T.G., additional, Erdurmuş, Mesut, additional, Esfandiari, Hamed, additional, Estévez-Santiago, Rocío, additional, Farajzadeh, Asghar, additional, Finnemann, Silvia C., additional, Fonseca, Francisco Antonio Helfenstein, additional, Fortenbach, Christopher, additional, Gehlbach, Peter L., additional, Gite, Snehal, additional, Goldman, Elissa, additional, Grieb, Paweł, additional, Haller, Julia A., additional, Han, Sang Beom, additional, Hayashi, Rijo, additional, Hecht, Idan, additional, Helfenstein, Tatiana, additional, Hogg, Ruth E, additional, Hyon, Joon Young, additional, Jin, Yao, additional, Jiramongkolchai, Kim, additional, K. Reddy, Rahul, additional, Kazal, Frances H., additional, Kerlin, Paul, additional, Kiefte-de Jong, Jessica C, additional, Kishan, Amar U., additional, Klaver, Caroline C W, additional, Kohno, Kimitoshi, additional, Lin, Dingbo, additional, Loewen, Nils A., additional, Maharshak, Idit, additional, Mathew, Shilpa, additional, Mazzoni, Francesca, additional, Miyamoto, Naoya, additional, Modjtahedi, Bobeck S., additional, Morse, Lawrence S., additional, Murahari, Manikanta, additional, Naranjit, Nara, additional, Obi, Robert Kelechi, additional, Olmedilla-Alonso, Begoña, additional, Paes-de-Carvalho, R., additional, Pintea, Adela, additional, Portugal, C.C., additional, Qin, Jiang, additional, Roizenblatt, Marina, additional, Rossi, Tommaso, additional, Rugină, Dumitriţa, additional, Saccà, Sergio Claudio, additional, Sandre, Poliana Capucho, additional, Sangave, Preeti C., additional, Sarkar, Megha, additional, Serfaty, Claudio Alberto, additional, Serra, Horacio M., additional, Shenge, Juliet Adamma, additional, Simavlı, Hüseyin, additional, Socodato, R., additional, Spinazzi, Marco, additional, Srinivasan, Krishnapura, additional, Storey, Philip P., additional, Suárez, María Fernanda, additional, Suvarna, Vasanti, additional, Tosun, Mehmet, additional, Vargas, Jade, additional, Woodside, Jayne V, additional, Wu, Lei, additional, Xi, Chen, additional, Yağcı, Ramazan, additional, Yong, Ji, additional, Zahra Bathaie, S., additional, and Žorić, Lepša, additional

Published
2019
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14. Posicionamento Brasileiro sobre Síndrome da Quilomicronemia Familiar – 2023

Author

Izar, Maria Cristina de Oliveira, primary, Santos, Raul Dias dos, additional, Assad, Marcelo Heitor Vieira, additional, Chagas, Antonio Carlos Palandri, additional, Toledo, Alceu de Oliveira, additional, Nogueira, Ana Cláudia Cavalcante, additional, Souto, Ana Cristina Carneiro Fernandes, additional, Lottenberg, Ana Maria Pitta, additional, Chacra, Ana Paula Marte, additional, Ferreira, Carlos Eduardo dos Santos, additional, Lourenço, Charles Marques, additional, Valerio, Cynthia Melissa, additional, Cintra, Dennys Esper, additional, Fonseca, Francisco Antonio Helfenstein, additional, Campana, Gustavo Aguiar, additional, Bianco, Henrique Tria, additional, Lima, Josivan Gomes de, additional, Castelo, Maria Helane Costa Gurgel, additional, Scartezini, Marileia, additional, Moretti, Miguel Antonio, additional, Barreto, Natasha Slhessarenko Fraife, additional, Maia, Rayana Elias, additional, Montenegro, Renan Magalhães, additional, Alves, Renato Jorge, additional, Figueiredo, Roberta Marcondes Machado, additional, Fock, Rodrigo Ambrosio, additional, and Martinez, Tânia Leme da Rocha, additional

Published
2023
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15. Chest Pain in Acute Myocardial Infarction and Its Association With the Culprit Artery and Fibrotic Segment Identified by Cardiac Magnetic Resonance

Author

Leite, Weverton Ferreira, primary, dos Santos Povoa, Rui Manuel, additional, Caixeta, Adriano Mendes, additional, Amodeo, Celso, additional, Szarf, Gilberto, additional, Bombig, Maria Teresa Nogueira, additional, Izar, Maria Cristina Oliveira, additional, Gioia, Luciana Netto, additional, Ribeiro, Wilma Noia, additional, and Fonseca, Francisco Antonio Helfenstein, additional

Published
2023
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17. About the Contributors

Author

Moise, Alexander R., primary, Abizaid, Alexandre, additional, Fiorelli, Alfredo Inácio, additional, de Moraes, Aline Alexandra Iannoni, additional, Sales, Allan Robson Kluser, additional, Nussbacher, Amit, additional, Andrade, Ana Cristina, additional, Lottenberg, Ana Maria, additional, Azambuja, Ana P., additional, Dantas, Ana Paula, additional, Costa, Ângela M.S., additional, Lopes, Antonio Augusto, additional, Chagas, Antonio Carlos Palandri, additional, Filho, Antonio Casela, additional, de Souza, Breno Bernardes, additional, Noel Bairey Merz, C., additional, Negrão, Carlos Eduardo, additional, Rocha Oliveira, Carlos J., additional, Echem, Cinthya, additional, Nobrega, Clara, additional, Camargo, Cristina Pires, additional, Chamie, Daniel, additional, Umpierre, Daniel, additional, Fernandes, Denise C., additional, Favarato, Desidério, additional, de Oliveira, Edilamar Menezes, additional, Rodrigues, Elaine Guadelupe, additional, Hojaij, Elaine Marques, additional, Akamine, Eliana Hiromi, additional, Bouskela, Eliete, additional, Haas, Elisa Alberton, additional, Ros, Emilio, additional, de Paula, Erich Vinicius, additional, Svensjö, Erik, additional, Jones, Erika, additional, Vanderlinde, Fabiano, additional, Mónica, Fabiola Zakia, additional, Borges, Fernanda Fatureto, additional, Consolim-Colombo, Fernanda Marciano, additional, Roque, Fernanda Roberta, additional, Bacal, Fernando, additional, Fonseca, Francisco Antonio Helfenstein, additional, Laurindo, Francisco R.M., additional, Lorenzi-Filho, Geraldo, additional, Sigal, Gilbert Alexandre, additional, De Nucci, Gilberto, additional, Garcia-Cardeña, Guillermo, additional, Oliveira de Paula, Gustavo Henrique, additional, Araújo, Haniel Alves, additional, Júnior, Heitor Moreno, additional, de Oliveira, Helena Coutinho Franco, additional, Castillo, Hozana A., additional, Monteiro, Hugo P., additional, de Campos, Iáscara Wozniak, additional, Aprahamian, Ivan, additional, Eduardo Sousa, J., additional, Ribamar Costa, J., additional, Wei, Janet, additional, Maughan, Jenna, additional, Merino, Jordi, additional, Krieger, José Eduardo, additional, Santos, José Eduardo Tanus dos, additional, de Lima, Jose Jayme Galvão, additional, Júnior, José Leudo Xavier, additional, Neto, José Rocha Faria, additional, Xavier-Neto, José, additional, Annichino-Bizzacchi, Joyce M., additional, Yugar-Toledo, Juan Carlos, additional, Tavares, Juliana Carvalho, additional, Marchini, Julio Flavio, additional, Katayama, Keyla Yukari, additional, Tanaka, Leonardo Y., additional, Colli, Lucas Giglio, additional, Drager, Luciano F., additional, Gowdak, Luís Henrique Wolff, additional, Bortolotto, Luiz Aparecido, additional, Liberman, Marcel, additional, Muscará, Marcelo Nicolás, additional, Nishiyama, Marcelo, additional, Zugaib, Marcelo, additional, Saffi, Marco Aurélio Lumertz, additional, Izar, Maria Cristina O., additional, de Carvalho, Maria Helena Catelli, additional, Alves, Maria Janieire de Nazaré Nunes, additional, Lavrador, Maria Silvia Ferrari, additional, Albuquerque, Maria Theresa O.M., additional, Clavé, Mariana Meira, additional, Moreira, Marina Beltrami, additional, Biella, Marina Maria, additional, Saad, Mario J.A., additional, Curcio, Marli F., additional, Wajngarten, Mauricio, additional, Gagliani, Mayra Luciana, additional, Andrades, Michael, additional, Afonso, Milessa Silva, additional, Carvalho, Murilo, additional, Clausell, Nadine, additional, Stolf, Noedir Antonio Groppo, additional, Berwanger, Otavio, additional, Leite, Paulo Ferreira, additional, Dourado, Paulo Magno Martins, additional, Evora, Paulo Roberto B., additional, Lemos, Pedro A., additional, Libby, Peter, additional, Shah, Prediman K., additional, da Luz, Protásio Lemos, additional, Mehta, Puja, additional, Maranhão, Raul Cavalcante, additional, Lacchini, Riccardo, additional, Kones, Richard, additional, Tostes, Rita C., additional, Borges, Roberta Eller, additional, Machado, Roberta Marcondes, additional, Giraldez, Roberto Rocha C.V., additional, Santos, Robson Augusto Souza dos, additional, Modolo, Rodrigo, additional, Gemperli, Rolf, additional, Francisco, Rossana Pulcineli Vieira, additional, Moncada, Salvador, additional, Tobar, Santiago A., additional, Kahhale, Soubhi, additional, Cau, Stefany B.A., additional, Araujo, Thaís L.S., additional, Fernandes, Tiago, additional, da Costa, Tiago Januário, additional, Costa-Hong, Valéria, additional, Esteves, Vinicius, additional, Giraldez, Viviane Zorzanelli Rocha, additional, Batista, Wagner Luiz, additional, and Sampaio, Walkyria Oliveira, additional

Published
2018
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19. Monocytes presenting a pro-inflammatory profile persist in patients submitted to a long-term pharmacological treatment after acute myocardial infarction

Author

de Carvalho, Daniel Carneiro, primary, Fonseca, Francisco Antonio Helfenstein, additional, Izar, Maria Cristina de Oliveira, additional, Silveira, Ana Luíza Pereira Assunção, additional, Tuleta, Izabela Dorota, additional, do Amaral, Jônatas Bussador, additional, Neves, Lucas Melo, additional, Bachi, André Luis Lacerda, additional, and França, Carolina Nunes, additional

Published
2023
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20. Metrics of Care and Cardiovascular Outcomes in Patients with ST-Elevation Myocardial Infarction Treated with Pharmacoinvasive Strategy: A Decade-long Network in a Populous City in Brazil

Author

Moraes, Pedro Ivo De Marqui, primary, Galhardo, Attilio, additional, Barbosa, Adriano Henrique Pereira, additional, de Sousa, Jose Marconi Almeida, additional, Alves, Claudia Maria Rodrigues, additional, Bianco, Henrique Tria, additional, Povoa, Rui Manuel dos Santos, additional, Stefanini, Edson, additional, Goncalves, Iran, additional, de Almeida, Dirceu Rodrigues, additional, Fonseca, Francisco Antonio Helfenstein, additional, Izar, Maria Cristina de Oliveira, additional, Moises, Valdir Ambrosio, additional, Lopes, Renato Delascio, additional, Carvalho, Antonio Carlos, additional, and Caixeta, Adriano, additional

Published
2023
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23. Metrics of care and cardiovascular outcomes in patients with ST-elevation myocardial infarction treated with pharmacoinvasive strategy: a decade-long network in a populous city in Brazil.

Author

De Marqui Moraes, Pedro Ivo, Galhardo, Attilio, Barbosa, Adriano Henrique Pereira, de Sousa, Jose Marconi Almeida, Alves, Claudia Maria Rodrigues, Bianco, Henrique Tria, dos Santos Povoa, Rui Manuel, Stefanini, Edson, Goncalves Jr, Iran, de Almeida, Dirceu Rodrigues, Fonseca, Francisco Antonio Helfenstein, de Oliveira Izar, Maria Cristina, Moises, Valdir Ambrosio, Lopes, Renato Delascio, Carvalho, Antonio Carlos, and Caixeta, Adriano

Subjects
ST elevation myocardial infarction, MYOCARDIAL reperfusion, PERCUTANEOUS coronary intervention, TREATMENT effectiveness, THROMBOLYTIC therapy, HOSPITAL mortality, INFARCTION, CARDIOVASCULAR fitness
Abstract

Background: Pharmacoinvasive strategy is an effective myocardial reperfusion therapy when primary percutaneous coronary intervention (p-PCI) cannot be performed in a timely manner. Methods: Authors sought to evaluate metrics of care and cardiovascular outcomes in a decade-long registry of a pharmacoinvasive strategy network for the treatment of ST-elevation myocardial infarction (STEMI). Data from a local network including patients undergoing fibrinolysis in county hospitals and systematically transferred to the tertiary center were accessed from March 2010 to September 2020. Numerical variables were described as median and interquartile range. Area under the curve (AUC-ROC) was used to analyze the predictive value of TIMI and GRACE scores for in-hospital mortality. Results: A total of 2,710 consecutive STEMI patients aged 59 [51–66] years, 815 women (30.1%) and 837 individuals with diabetes (30.9%) were analyzed. The time from symptom onset to first-medical-contact was 120 [60–210] minutes and the door-to-needle time was 70 [43–115] minutes. Rescue-PCI was required in 929 patients (34.3%), in whom the fibrinolytic-catheterization time was 7.2 [4.9–11.8] hours, compared to 15.7 [6.8–22,7] hours in those who had successful lytic reperfusion. All cause in-hospital mortality occurred in 151 (5.6%) patients, reinfarction in 47 (1.7%) and ischemic stroke in 33 (1.2%). Major bleeding occurred in 73 (2.7%) patients, including 19 (0.7%) cases of intracranial bleeding. C-statistic confirmed that both scores had high predictive values for in-hospital mortality, demonstrated by TIMI AUC-ROC of 0.80 [0,77–0.84] and GRACE AUC-ROC of 0.86 [0.83—0.89]. Conclusion: In a real world registry of a decade-long network for the treatment of ST-elevation myocardial infarction based on the pharmacoinvasive strategy, low rates of in-hospital mortality and cardiovascular outcomes were observed, despite prolonged time metrics for both fibrinolytic therapy and rescue-PCI. Register Clinicaltrials.gov NCT02090712 date of first registration 18/03/2014. [ABSTRACT FROM AUTHOR]

Published
2023
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25. Atualização da Diretriz Brasileira de Hipercolesterolemia Familiar – 2021

Author

Izar, Maria Cristina de Oliveira, primary, Giraldez, Viviane Zorzanelli Rocha, additional, Bertolami, Adriana, additional, Santos, Raul Dias dos, additional, Lottenberg, Ana Maria, additional, Assad, Marcelo Heitor Vieira, additional, Saraiva, José Francisco Kerr, additional, Chacra, Ana Paula M., additional, Martinez, Tania L. R., additional, Bahia, Luciana Ribeiro, additional, Fonseca, Francisco Antonio Helfenstein, additional, Faludi, Andre Arpad, additional, Sposito, Andrei C., additional, Chagas, Antônio Carlos Palandri, additional, Jannes, Cinthia Elim, additional, Amaral, Cristiane Kovacs, additional, Araújo, Daniel Branco de, additional, Cintra, Dennys Esper, additional, Coutinho, Elaine dos Reis, additional, Cesena, Fernando, additional, Xavier, Hermes Toros, additional, Mota, Isabela Cardoso Pimentel, additional, Giuliano, Isabela de Carlos Back, additional, Faria, José Rocha, additional, Kato, Juliana Tieko, additional, Bertolami, Marcelo Chiara, additional, Miname, Marcio Hiroshi, additional, Castelo, Maria Helane Costa Gurgel, additional, Lavrador, Maria Sílvia Ferrari, additional, Machado, Roberta Marcondes, additional, Souza, Patrícia Guedes de, additional, Alves, Renato Jorge, additional, Machado, Valeria Arruda, additional, and Salgado, Wilson, additional

Published
2021
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26. Posicionamento sobre o Consumo de Gorduras e Saúde Cardiovascular – 2021

Author

Izar, Maria Cristina de Oliveira, primary, Lottenberg, Ana Maria, additional, Giraldez, Viviane Zorzanelli Rocha, additional, Santos, Raul Dias dos, additional, Machado, Roberta Marcondes, additional, Bertolami, Adriana, additional, Assad, Marcelo Heitor Vieira, additional, Saraiva, José Francisco Kerr, additional, Faludi, André Arpad, additional, Moreira, Annie Seixas Bello, additional, Geloneze, Bruno, additional, Magnoni, Carlos Daniel, additional, Scherr, Carlos, additional, Amaral, Cristiane Kovacs, additional, Araújo, Daniel Branco de, additional, Cintra, Dennys Esper Corrêa, additional, Nakandakare, Edna Regina, additional, Fonseca, Francisco Antonio Helfenstein, additional, Mota, Isabela Cardoso Pimentel, additional, Santos, José Ernesto dos, additional, Kato, Juliana Tieko, additional, Beda, Lis Mie Misuzawa, additional, Vieira, Lis Proença, additional, Bertolami, Marcelo Chiara, additional, Rogero, Marcelo Macedo, additional, Lavrador, Maria Silvia Ferrari, additional, Nakasato, Miyoko, additional, Damasceno, Nagila Raquel Teixeira, additional, Alves, Renato Jorge, additional, Roberta Soares, Lara, additional, Costa, Rosana Perim, additional, and Machado, Valéria Arruda, additional

Published
2021
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28. Physical Activity and Healthy Eating Patterns in Public Schools in Brazil: A Strategy to Avert Risk Factors in Adulthood

Author

Izar, Maria Cristina de Oliveira and Fonseca, Francisco Antonio Helfenstein

Subjects
lcsh:Diseases of the circulatory (Cardiovascular) system, Adolescent, Healthy Diet, business.industry, Cross-sectional study, Risk Factors/prevention and control, Exercício, Physical activity, MEDLINE, Healthy eating, Healthy diet, Feeding behavior, lcsh:RC666-701, Dieta Saudável, Environmental health, Fatores de Risco/prevenção e controle, Medicine, Short Editorial, Cardiology and Cardiovascular Medicine, business, Exercise, Adolescente
Published
2019

30. Apresentação Rara de Doença de Dercum em Criança com Anormalidades no Metabolismo de Lipoproteínas

Author

Izar,Maria Cristina de Oliveira, Fonseca,Henrique Andrade Rodrigues da, França,Carolina Nunes, Machado,Valéria Arruda, Ferreira,Carlos Eduardo dos Santos, and Fonseca,Francisco Antonio Helfenstein

Subjects
Adiposis Dolorosa, Inflammation, Inflamação, Dislipidemias, Rare Diseases, Doenças Raras, Lipid Metabolism Disorders, Criança, Child, Transtornos do Metabolismo dos Lipídeos, Dyslipidemias
Published
2018

31. Predictors of Family Recruitment in a Program of Genetic Cascade Screening for Familial Hypercholesterolemia

Author

Izar, Maria Cristina de Oliveira and Fonseca, Francisco Antonio Helfenstein

Subjects
Hipercolesterolemia Tipo II/genética, Hyperlipoproteinemia Type II/genetic, Hipercolesterolemia/tratamento preventivo, Lipid Metabolism Disorders, Family Health Strategy, Estratégia Saúde da Família, Hyperlipoproteinemia/prevention &control, Transtornos do Metabolismo Lipídico
Published
2018

32. Updated Cardiovascular Prevention Guideline of the Brazilian Society of Cardiology - 2019

Author

Précoma, Dalton Bertolim, primary, Oliveira, Gláucia Maria Moraes de, additional, Simão, Antonio Felipe, additional, Dutra, Oscar Pereira, additional, Coelho-Filho, Otávio Rizzi, additional, Izar, Maria Cristina de Oliveira, additional, Póvoa, Rui Manuel dos Santos, additional, Giuliano, Isabela de Carlos Back, additional, Alencar Filho, Aristóteles Comte de, additional, Machado, Carlos Alberto, additional, Scherr, Carlos, additional, Fonseca, Francisco Antonio Helfenstein, additional, Santos Filho, Raul Dias dos, additional, Carvalho, Tales de, additional, Avezum Júnior, A'lvaro, additional, Esporcatte, Roberto, additional, Nascimento, Bruno Ramos, additional, Brasil, David de Pádua, additional, Soares, Gabriel Porto, additional, Villela, Paolo Blanco, additional, Ferreira, Roberto Muniz, additional, Martins, Wolney de Andrade, additional, Sposito, Andrei C., additional, Halpern, Bruno, additional, Saraiva, José Francisco Kerr, additional, Carvalho, Luiz Sergio Fernandes, additional, Tambascia, Marcos Antônio, additional, Coelho Filho, Otávio Rizzi, additional, Bertolami, Adriana, additional, Correa Filho, Harry, additional, Xavier, Hermes Toros, additional, Faria-Neto, José Rocha, additional, Bertolami, Marcelo Chiara, additional, Giraldez, Viviane Zorzanelli Rocha, additional, Brandão, Andrea Araújo, additional, Feitosa, Audes Diógenes de Magalhães, additional, Amodeo, Celso, additional, Souza, Dilma do Socorro Moraes de, additional, Barbosa, Eduardo Costa Duarte, additional, Malachias, Marcus Vinícius Bolívar, additional, Souza, Weimar Kunz Sebba Barroso de, additional, Costa, Fernando Augusto Alves da, additional, Rivera, Ivan Romero, additional, Pellanda, Lucia Campos, additional, Silva, Maria Alayde Mendonça da, additional, Achutti, Aloyzio Cechella, additional, Langowiski, André Ribeiro, additional, Lantieri, Carla Janice Baister, additional, Scholz, Jaqueline Ribeiro, additional, Ismael, Silvia Maria Cury, additional, Ayoub, José Carlos Aidar, additional, Scala, Luiz César Nazário, additional, Neves, Mario Fritsch, additional, Jardim, Paulo Cesar Brandão Veiga, additional, Fuchs, Sandra Cristina Pereira Costa, additional, Jardim, Thiago de Souza Veiga, additional, Moriguchi, Emilio Hideyuki, additional, Schneider, Jamil Cherem, additional, Assad, Marcelo Heitor Vieira, additional, Kaiser, Sergio Emanuel, additional, Lottenberg, Ana Maria Pita, additional, Magnoni, Carlos Daniel, additional, Miname, Marcio Hiroshi, additional, Lara, Roberta Soares, additional, Herdy, Artur Haddad, additional, Araújo, Cláudio Gil Soares de, additional, Milani, Mauricio, additional, Silva, Miguel Morita Fernandes da, additional, Stein, Ricardo, additional, Lucchese, Fernando Antonio, additional, Nobre, Fernando, additional, Griz, Hermilo Borba, additional, Magalhães, Lucélia Batista Neves Cunha, additional, Borba, Mario Henrique Elesbão de, additional, Pontes, Mauro Ricardo Nunes, additional, and Mourilhe-Rocha, Ricardo, additional

Published
2019
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34. Regional QT Interval Dispersion as an Early Predictor of Reperfusion in Patients with Acute Myocardial Infarction after Fibrinolytic Therapy

Author

Dotta, Gabriel, primary, Fonseca, Francisco Antonio Helfenstein, additional, Izar, Maria Cristina de Oliveira, additional, Souza, Marco Tulio de, additional, Moreira, Flavio Tocci, additional, Pinheiro, Luiz Fernando Muniz, additional, Barbosa, Adriano Henrique Pereira, additional, Caixeta, Adriano Mendes, additional, Póvoa, Rui Manoel Santos, additional, Carvalho, Antônio Carlos, additional, and Bianco, Henrique Tria, additional

Published
2018
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39. Brazilian guidelines on prevention of cardiovascular disease in patients with diabetes: a position statement from the Brazilian Diabetes Society (SBD), the Brazilian Cardiology Society (SBC) and the Brazilian Endocrinology and Metabolism Society (SBEM)

Author

Bertoluci, Marcello Casaccia, primary, Moreira, Rodrigo Oliveira, additional, Faludi, André, additional, Izar, Maria Cristina, additional, Schaan, Beatriz D., additional, Valerio, Cynthia Melissa, additional, Bertolami, Marcelo Chiara, additional, Chacra, Ana Paula, additional, Malachias, Marcus Vinicius Bolivar, additional, Vencio, Sérgio, additional, Saraiva, José Francisco Kerr, additional, Betti, Roberto, additional, Turatti, Luiz, additional, Fonseca, Francisco Antonio Helfenstein, additional, Bianco, Henrique Tria, additional, Sulzbach, Marta, additional, Bertolami, Adriana, additional, Salles, João Eduardo Nunes, additional, Hohl, Alexandre, additional, Trujilho, Fábio, additional, Lima, Eduardo Gomes, additional, Miname, Marcio Hiroshi, additional, Zanella, Maria Teresa, additional, Lamounier, Rodrigo, additional, Sá, João Roberto, additional, Amodeo, Celso, additional, Pires, Antonio Carlos, additional, and Santos, Raul D., additional

Published
2017
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41. Association of Multiple Genetic Variants with the Extension and Severity of Coronary Artery Disease

Author

Fischer, Simone Cristina Pinto Matheus, primary, Pinto, Simone Pires, additional, Lins, Lívia Campos do Amaral Silva, additional, Bianco, Henrique Tria, additional, Monteiro, Carlos Manoel de Castro, additional, Pinheiro, Luiz Fernando Muniz, additional, Fonseca, Francisco Antonio Helfenstein, additional, and Izar, Maria Cristina de Oliveira, additional

Published
2017
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42. Microparticles as Potential Biomarkers of Cardiovascular Disease

Author

França, Carolina Nunes, Izar, Maria Cristina de Oliveira, Amaral, Jônatas Bussador do, Tegani, Daniela Melo, and Fonseca, Francisco Antonio Helfenstein

Subjects
Doenças cardiovasculares, Aterosclerose / prevenção & controle, Cell-Derived Microparticles, Atherosclerosis / prevention & control, Cardiovascular Diseasesv, Micropartículas Derivadas de Células, Biomarkers, Pharmacological / analysis, Biomarcadores Farmacológicos / análise
Abstract

Primary prevention of cardiovascular disease is a choice of great relevance because of its impact on health. Some biomarkers, such as microparticles derived from different cell populations, have been considered useful in the assessment of cardiovascular disease. Microparticles are released by the membrane structures of different cell types upon activation or apoptosis, and are present in the plasma of healthy individuals (in levels considered physiological) and in patients with different pathologies. Many studies have suggested an association between microparticles and different pathological conditions, mainly the relationship with the development of cardiovascular diseases. Moreover, the effects of different lipid-lowering therapies have been described in regard to measurement of microparticles. The studies are still controversial regarding the levels of microparticles that can be considered pathological. In addition, the methodologies used still vary, suggesting the need for standardization of the different protocols applied, aiming at using microparticles as biomarkers in clinical practice. A prevenção primária da doença cardiovascular constitui uma opção de grande relevância pelos seus impactos na saúde. Alguns biomarcadores têm sido considerados úteis na avaliação da doença cardiovascular, dentre eles micropartículas originadas de diferentes populações de células. Micropartículas são estruturas liberadas pela membrana de diferentes tipos celulares após ativação ou apoptose, presentes tanto no plasma de indivíduos saudáveis (níveis considerados fisiológicos) quanto em portadores de diferentes doenças. Muitos estudos têm sugerido uma associação entre micropartículas e diferentes condições patológicas, destacando-se a relação com o desenvolvimento das doenças cardiovasculares. Além disso, têm sido descritos os efeitos de diferentes terapias hipolipemiantes na mensuração de micropartículas. Os estudos ainda são controversos quanto aos níveis de micropartículas que possam ser considerados patológicos, e os métodos utilizados ainda são variados, o que sugere a necessidade da padronização dos diferentes protocolos utilizados, visando à utilização de micropartículas como biomarcadores úteis na prática clínica.

Published
2015

43. Effects of High-Intensity Training of Professional Runners on Myocardial Hypertrophy and Subclinical Atherosclerosis

Author

Bittencourt, Célia Regina de Oliveira, primary, Izar, Maria Cristina de Oliveira, additional, Schwerz, Valdir Lauro, additional, Póvoa, Rui Manuel dos Santos, additional, Fonseca, Henrique Andrade Rodrigues, additional, Fonseca, Marília Izar Helfenstein, additional, Bianco, Henrique Tria, additional, França, Carolina Nunes, additional, Ferreira, Carlos Eduardo dos Santos, additional, and Fonseca, Francisco Antonio Helfenstein, additional

Published
2016
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44. Electrocardiogram Performance in the Diagnosis of Left Ventricular Hypertrophy in Hypertensive Patients With Left Bundle Branch Block

Author

Burgos, Paula Freitas Martins, primary, Luna Filho, Bráulio, additional, Costa, Francisco de Assis, additional, Bombig, Maria Teresa Nogueira, additional, Souza, Dilma de, additional, Bianco, Henrique Tria, additional, Oliveira Filho, Japy Angelini, additional, Izar, Maria Cristina de Oliveira, additional, Fonseca, Francisco Antonio Helfenstein, additional, and Póvoa, Rui, additional

Published
2016
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46. Evaluación de la hipertensión arterial resistente por monitoreo residencial de la presión arterial

Author

Marui, Fabiane Rosa Rezende H., Bombig, Maria Teresa Nogueira, Francisco, Yoná Afonso, Thalenberg, José Marcos, Fonseca, Francisco Antonio Helfenstein, Souza, Dilma de, Costa, Francisco de Assis, Izar, Maria Cristina, Carvalho, Antonio Carlos de Camargo, and Póvoa, Rui

Subjects
monitorização ambulatorial da pressão arterial, blood pressure monitoring, ambulatory, monitoreo ambulatorio de la presión arterial, Hypertension, Hipertensión, blood pressure, pressão arterial, presión arterial, Hipertensão
Abstract

FUNDAMENTO: A monitorização ambulatorial da pressão arterial (MAPA) é considerada o padrão-ouro para a confirmação diagnóstica da hipertensão arterial resistente (HAR). No entanto, a monitorização residencial da pressão arterial (MRPA) tem sido considerada uma opção, pelo seu custo menor e maior conforto. OBJETIVO: Comparar os valores obtidos pela MRPA com os obtidos pela MAPA na identificação de pacientes hipertensos resistentes. MÉTODOS: Foram selecionados consecutivamente 51 pacientes hipertensos resistentes, adultos de ambos os sexos, em tratamento ambulatorial de referência, de jan/2007 a set/2009. A medida da pressão arterial (PA) casual de consultório, MAPA de 24 horas e MRPA foram realizadas conforme as diretrizes vigentes, com intervalo máximo de duas semanas entre os métodos. RESULTADOS: Ao comparar a MAPA (média de vigília) e MRPA, foi obtida boa correlação entre ambas, tanto para a pressão arterial sistólica (PAS) quanto para a diastólica (PAD): PAS r = 0,70, IC = 0,51-0,82; PAD r = 0,69, IC = 0,52-0,81. A HAR foi confirmada pela MAPA em 33 pacientes e pela MRPA em 37 desses, não havendo diferença significante entre os dois métodos. CONCLUSÃO: De acordo com os resultados obtidos, conclui-se que a MRPA é um exame que pode ser utilizado como alternativa à MAPA para a confirmação diagnóstica da HAR. BACKGROUND: Ambulatory blood pressure monitoring (ABPM) is considered the gold standard for the diagnostic confirmation of resistant hypertension (RH). However, home blood pressure monitoring (HBPM) has been considered an option, because of its lower cost and greater comfort. OBJECTIVE: To compare the values obtained by HBPM with those obtained by ABPM in the identification of patients with resistant hypertension. METHODS: A total of 51 consecutive patients with resistant hypertension were selected. All were adults of both genders and were undergoing treatment in an outpatient referral clinic from January 2007 to September 2009. Casual office blood pressure (BP), 24-hour ABPM, and HBPM were performed according to current guidelines, with a maximum two-week interval between the methods. RESULTS: The comparison of ABPM (mean daytime) with HBPM showed a good correlation between them, both for systolic blood pressure (SBP) and for diastolic blood pressure (DBP): SBP r = 0.70, CI = 0.51-0.82, DBP r = 0.69, CI = 0.52-0.81. RH was confirmed by ABPM in 33 patients and by HBPM in 37, with no significant difference between the methods. CONCLUSION: According to the results obtained, we conclude that HBPM is a method that can be used as an alternative to ABPM for the diagnostic confirmation of RH. FUNDAMENTO: El monitoreo ambulatorio de la presión arterial (MAPA) es considerado el gold standard para la confirmación diagnóstica de la hipertensión arterial resistente (HAR). Mientras tanto, el monitoreo residencial de la presión arterial (MRPA) ha sido considerado una opción, por su costo menor y mayor confort. OBJETIVO: Comparar los valores obtenidos por la MRPA con los obtenidos por la MAPA en la identificación de pacientes hipertensos resistentes. MÉTODOS: Fueron seleccionados consecutivamente 51 pacientes hipertensos resistentes, adultos de ambos sexos, en tratamiento ambulatorio de referencia, de ene/2007-set/2009. La medida de la presión arterial (PA) casual de consultorio, MAPA de 24 horas y MRPA fueron realizadas según las directrices vigentes, con intervalo máximo de dos semanas entre los métodos. RESULTADOS: Al comparar la MAPA (media de vigilia) y MRPA, fue obtenida buena correlación entre ambas, tanto para la presión arterial sistólica (PAS) como para la diastólica (PAD): PAS r = 0,70, IC = 0,51-0,82; PAD r = 0,69, IC = 0,52-0,81. La HAR fue confirmada por la MAPA en 33 pacientes y por la MRPA en 37 de esos, no habiendo diferencia significativa entre los dos métodos. CONCLUSIÓN: De acuerdo con los resultados obtenidos, se concluye que la MRPA es un examen que puede ser utilizado como alternativa a la MAPA para la confirmación diagnóstica de la HAR.

Published
2010

47. Efeitos da terapia combinada atorvastatina e clopidogrel na biodisponibilidade da estatina e na função plaquetária em pacientes com doença coronária estável

Author

Pinheiro, Luiz Fernando Muniz, Izar, Maria Cristina de Oliveira, Kasmas, Soraia Kani, França, Carolina Nunes, Fischer, Simone Cristina Matheus, Barbosa, Simone Pinto de Melo, Nucci, Gilberto de, Ilha, Jaime, Chen, Lu Chi, Carvalho, Antonio Carlos, Póvoa, Rui Manoel dos Santos, Bianco, Henrique Tria, and Fonseca, Francisco Antonio Helfenstein

Subjects
Doenças cardiovasculares, Agregação plaquetária, Cardiovascular diseases, Farmacocinética, Platelet aggregation, Pharmacokinetics
Abstract

INTRODUÇÃO: Atorvastatina 80 mg é recomendada a pacientes portadores de doença coronária para redução de eventos cardiovasculares, havendo controvérsia sobre as interações farmacocinéticas entre doses elevadas das estatinas e uso concomitante de clopidogrel, por compartilharem a mesma via de biotransformação. Este estudo avaliou os efeitos da terapia combinada atorvastatina/clopidogrel na farmacocinética da estatina e função plaquetária em pacientes com doença coronária estável, sob uso crônico e efetivo de estatina MÉTODO: Os pacientes foram admitidos quatro vezes para internação (V1 a V4) em leito-dia. Sete dias (D) antes da primeira internação a estatina em uso foi suspensa. A seguir, receberam atorvastatina 80 mg (D1 a D22) e clopidogrel 75 mg/dia (D8 a D29). Em todas as V foram obtidas amostras de sangue em jejum para dosagens lipídicas, avaliação da função plaquetária (técnica da placa e cone) e quantificação dos níveis plasmáticos de atorvastatina (cromatografia líquida e espectrometria de massa) RESULTADOS: A suspensão por uma semana da estatina modificou o perfil lipídico (P < 0,05 vs. basal), ocorrendo rápida melhora de todas as frações lipídicas após atorvastatina 80 mg (P < 0,005; V1 > V2, V3 e V4). A adesão plaquetária foi menor com clopidogrel isolado (P = 0,003; V4 < V1, V2 e V3), enquanto para a agregação houve menor valor com tratamento combinado atorvastatina/clopidogrel ou clopidogrel isolado comparado aos demais períodos (P < 0,0001; V3 e V4 < V1 e V2). O clopidogrel não modificou as concentrações de atorvastatina CONCLUSÃO: Atorvastatina em alta dose não afetou as respostas plaquetárias ao clopidogrel; entretanto, curto período de suspensão da estatina piorou o perfil lipídico e a função plaquetária. BACKGROUND: Atorvastatin 80 mg is recommended in patients with coronary artery disease to reduce cardiovascular events, however, there is controversy regarding the pharmacokinetic interactions between high doses of statins and the concomitant use of clopidogrel, since they share the same biotransformation pathway. This study evaluated the effects of the atorvastatin/clopidogrel combination therapy on the pharmacokinetics of statins and on platelet function of patients with stable coronary artery disease receiving chronic statins METHOD: Patients were admitted four times (V1 to V4) to a day-clinic. Statin was discontinued seven days (D) before the first admission. Patients then received atorvastatin 80 mg (D1 to D22) and clopidogrel 75 mg/day (D8 to D29). Fasting blood samples were obtained at all time points for lipid measurements, platelet function tests (cone and plate technique), and quantification of atorvastatin plasma levels (liquid chromatography and mass spectrometry) RESULTS: The discontinuation of statins for one week changed the lipid profile (P < 0.05 vs. baseline), with an early improvement of all lipid parameters after the administration of atorvastatin 80 mg (P < 0.005; V1 > V2, V3 and V4). Platelet adhesion was lower with clopidogrel alone (P = 0.003; V4 < V1, V2 and V3), whereas platelet aggregation values were lower following the atorvastatin/clopidogrel combination therapy or clopidogrel alone when compared to the other time points (P < 0.0001; V3 and V4 < V1 and V2). The use of clopidogrel did not affect atorvastatin serum levels CONCLUSION: High-dose atorvastatin did not affect platelet responses to clopidogrel, however the short-term statin discontinuation worsened the lipid profile and platelet function.

Published
2010

48. Farmacocinética das estatinas

Author

Fonseca, Francisco Antonio Helfenstein

Subjects
interação com drogas, Statins, farmacocinéticas, drug interactions, pharmacokinetics, Estatinas
Abstract

As estatinas são agentes hipolipemiantes que exercem os seus efeitos através da inibição da HMG-CoA redutase, enzima fundamental na síntese do colesterol, levando a uma redução do colesterol tecidual e um conseqüente aumento na expressão dos receptores de LDL. Existem consideráveis diferenças entre as estatinas, no que tange às propriedades farmacocinéticas, bem como ao coeficiente de hidrofilicidade, via hepática de metabolização (especialmente, do citocromo P450 e isoenzimas), meia-vida plasmática e eficácia na redução lipídica. As estatinas também podem diferir na capacidade de interação com outras drogas que utilizam a mesma via de metabolização. Recentemente, muitos efeitos pleiotrópicos têm sido relatados com estas drogas, bem como propriedades antiinflamatórias, melhora na função endotelial e benefícios na hemostasia. Statins are lipid lowering agents that promote their effects on plasma lipids through the inhibition of HMG-CoA reductase, a crucial enzyme in the cascade of cholesterol synthesis, leading to reduction of tissue cholesterol pool and consequently, to an upregulation of the LDL receptor expression. There are considerable differences among statins regarding some pharmacokinetic properties, such as the coefficient of hydrophilicity, via liver metabolism (especially regarding P450 cytochrome and isoenzymes), plasma half-life and efficacy of serum lipid changes. They may also differ regarding interactions with other drugs that share the same pathway of metabolism. Recently, many pleiotropic effects have been reported with these drugs, such as anti-inflammatory properties, improvement in endothelial function and benefits on hemostasis.

Published
2005

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