Search

Serotonin reuptake inhibitors (SRIs), including selective SRIs (SSRIs) and other psychotropic medications, are used to treat a variety of psychiatric conditions, including many mood and anxiety disorders. They are among [...]

Serotonin reuptake inhibitors (SRIs), including selective SRIs (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs), are common treatments for many psychiatric conditions. SRIs are a first-line therapy for major depressive disorder (MDD), [...]

The article discusses bleeding risk with selective serotonin reuptake inhbitors (SSRI) with cardiovascular and cerebrovascular considerations. Topics covered include antidepressant-associated bleeding categorized by complication, heart failure and ventricular assist devices, and thromboembolic disease. Also noted is the influence of other factors on antidepressant-associated bleeding

Aim: In this mixed‐methods study, we examined client descriptions of counselling outcomes and how they corresponded with a quantitative measure of change (i.e., Outcome Questionnaire‐45; OQ‐45). Method: Using purposeful sampling at a university counselling training centre, we compared 17 clients who had reliably improved, deteriorated or did not change to qualitative outcomes based on post‐counselling interviews using the Change Interview protocol. Results: Qualitative outcomes included two Central change categories, the first of which included interpersonal, cognitive and behavioural, affective, and attitude changes. The second Central category of outcomes comprised four areas of change that varied by degree of change expressed (i.e., Problem Resolution, Confidence, Happiness and Changes Affirmed by Others). Congruence was not present between OQ‐45 and Central 1 changes but was present for three of the four Central 2 changes (Problem Resolution, Happiness and Changes Affirmed by Others), all correlating above.60. Conclusion: OQ‐45 change scores showed congruence with three qualitative outcomes: degree of expressed improvement in Happiness, Problem resolution and changes noticed by significant others. However, the lack of congruence for Central 1 changes (i.e., Interpersonal, Cognitive and Behavioural, Affective, and Attitude Change) suggests a diverse range of outcomes important to clients that go undetected using the OQ‐45. We strongly encourage further mixed design research to better understand how best to appraise clinical improvement. [ABSTRACT FROM AUTHOR]