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1. Severe COVID-19 patients exhibit elevated levels of autoantibodies targeting cardiolipin and platelet glycoprotein with age: a systems biology approach

Author

Fonseca, Dennyson Leandro M., Filgueiras, Igor Salerno, Marques, Alexandre H. C., Vojdani, Elroy, Halpert, Gilad, Ostrinski, Yuri, Baiocchi, Gabriela Crispim, Plaça, Desirée Rodrigues, Freire, Paula P., Pour, Shahab Zaki, Moll, Guido, Catar, Rusan, Lavi, Yael Bublil, Silverberg, Jonathan I., Zimmerman, Jason, Cabral-Miranda, Gustavo, Carvalho, Robson F., Khan, Taj Ali, Heidecke, Harald, Dalmolin, Rodrigo J. S., Luchessi, Andre Ducati, Ochs, Hans D., Schimke, Lena F., Amital, Howard, Riemekasten, Gabriela, Zyskind, Israel, Rosenberg, Avi Z., Vojdani, Aristo, Shoenfeld, Yehuda, and Cabral-Marques, Otavio

Published
2023
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2. Cross-sectional analysis of students and school workers reveals a high number of asymptomatic SARS-CoV-2 infections during school reopening in Brazilian cities

Author

Borges, Lysandro P., Guimarães, Adriana G., Fonseca, Dennyson Leandro M., Freire, Paula P., Barreto, Íkaro D.C., Souza, Daniela R.V., Gurgel, Ricardo Q., Lopes, Aline S.A., Melquiades de Rezende Neto, José, dos Santos, Kezia A., Matos, Igor L.S., da Invenção, Grazielly B., Oliveira, Brenda M., Santos, Aryanne A., Soares, Daniele Almeida, de Jesus, Pamela C., dos Santos, Cliomar A., Goes, Marco A.O., Plaça, Desirée Rodrigues, Filgueiras, Igor Salerno, Marques, Alexandre H.C., Baiocchi, Gabriela Crispim, Cabral-Miranda, William, Cabral de Miranda, Gustavo, Saraiva Camara, Niels Olsen, Garcia Calich, Vera Lúcia, Ramos, Rodrigo Nalio, Nakaya, Helder I., Rocha, Vanderson, Giil, Lasse M., Ochs, Hans D., Schimke, Lena F., de Souza, Mércia S.F., Cuevas, Luis E., Martins, Aline F., and Cabral-Marques, Otavio

Published
2022
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3. Autoantibodies targeting GPCRs and RAS-related molecules associate with COVID-19 severity

Author

Cabral-Marques, Otavio, Halpert, Gilad, Schimke, Lena F., Ostrinski, Yuri, Vojdani, Aristo, Baiocchi, Gabriela Crispim, Freire, Paula Paccielli, Filgueiras, Igor Salerno, Zyskind, Israel, Lattin, Miriam T., Tran, Florian, Schreiber, Stefan, Marques, Alexandre H. C., Plaça, Desirée Rodrigues, Fonseca, Dennyson Leandro M., Humrich, Jens Y., Müller, Antje, Giil, Lasse M., Graßhoff, Hanna, Schumann, Anja, Hackel, Alexander, Junker, Juliane, Meyer, Carlotta, Ochs, Hans D., Lavi, Yael Bublil, Scheibenbogen, Carmen, Dechend, Ralf, Jurisica, Igor, Schulze-Forster, Kai, Silverberg, Jonathan I., Amital, Howard, Zimmerman, Jason, Heidecke, Harry, Rosenberg, Avi Z., Riemekasten, Gabriela, and Shoenfeld, Yehuda

Published
2022
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4. Integrative Systems Immunology Analysis Reveals Elevated Anti-AGTR1 Levels with Accumulating COVID-19 Symptoms

Author

Fonseca, Dennyson Leandro M, primary, Jäpel, Maj, additional, Filgueiras, Igor Salerno, additional, Baiochi, Gabriela Crispim, additional, Ostrinski, Yuri, additional, Halpert, Gilad, additional, Lavi, Yael Bublil, additional, Vojdani, Elroy, additional, Santos e Silva, Juan Carlo, additional, Usuda, Júlia Nakanishi, additional, Freire, Paula P., additional, Nóbile, Adriel Leal, additional, Adri, Anny Silva, additional, Marçal, Pedro Barcelos, additional, Corrêa, Yohan Lucas Gonçalves, additional, Nery do Vale, Fernando Yuri, additional, Lopes, Letícia Oliveira, additional, Schmidt, Solveig Lea, additional, Wang, Xiaoqing, additional, Vahldieck, Carl, additional, Fels, Benedikt, additional, Schimke, Lena F., additional, Hirata, Mario Hiroyuki, additional, Miranda, Gustavo Cabral-, additional, AKhan, Taj Ali, additional, Catar, Rusan, additional, Moll, Guido, additional, Silva-Sousa, Thayna, additional, Yu, Yen-Rei A, additional, Dalmolin, Rodrigo JS, additional, Amital, Howard, additional, Vojdani, Aristo, additional, Nakaya, Helder, additional, Ochs, Hans D., additional, Silverberg, Jonathan I., additional, Zimmerman, Jason, additional, Zyskind, Israel, additional, Rosenberg, Avi Z, additional, Schulze-Forster, Kai, additional, Heidecke, Harald, additional, Hackel, Alexander, additional, Kusche-Vihrog, Kristina, additional, Shoenfeld, Yehuda, additional, Riemekasten, Gabriela, additional, Akbarzadeh, Reza, additional, Marques, Alexandre H.C, additional, and Cabral-Marques, Otavio, additional

Published
2024
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5. Blocking the CTLA-4 and PD-1 pathways during pulmonary paracoccidioidomycosis improves immunity, reduces disease severity, and increases the survival of infected mice

Author

Preite, Nycolas Willian, primary, Borges, Bruno Montanari, additional, Kaminski, Valéria de Lima, additional, Ayupe, Marina Caçador, additional, Gonçalves, Leonardo Mandu, additional, dos Santos, Bianca Vieira, additional, Fonseca, Dennyson Leandro M., additional, Filgueiras, Igor Salerno, additional, Salgado, Caio Loureiro, additional, Muxel, Sandra Marcia, additional, Cabral-Marques, Otavio, additional, da Fonseca, Denise Morais, additional, Loures, Flávio Vieira, additional, and Calich, Vera Lúcia Garcia, additional

Published
2024
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6. Immunological signatures unveiled by integrative systems vaccinology characterization of dengue vaccination trials and natural infection

Author

Plaça, Desirée Rodrigues, primary, Fonseca, Dennyson Leandro M., additional, Marques, Alexandre H. C., additional, Zaki Pour, Shahab, additional, Usuda, Júlia Nakanishi, additional, Baiocchi, Gabriela Crispim, additional, Prado, Caroline Aliane de Souza, additional, Salgado, Ranieri Coelho, additional, Filgueiras, Igor Salerno, additional, Freire, Paula Paccielli, additional, Rocha, Vanderson, additional, Camara, Niels Olsen Saraiva, additional, Catar, Rusan, additional, Moll, Guido, additional, Jurisica, Igor, additional, Calich, Vera Lúcia Garcia, additional, Giil, Lasse M., additional, Rivino, Laura, additional, Ochs, Hans D., additional, Cabral-Miranda, Gustavo, additional, Schimke, Lena F., additional, and Cabral-Marques, Otavio, additional

Published
2024
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7. The network interplay of interferon and Toll-like receptor signaling pathways in the anti-Candida immune response

Author

Salgado, Ranieri Coelho, Fonseca, Dennyson Leandro M., Marques, Alexandre H. C., da Silva Napoleao, Sarah Maria, França, Tábata Takahashi, Akashi, Karen Tiemi, de Souza Prado, Caroline Aliane, Baiocchi, Gabriela Crispim, Plaça, Desirée Rodrigues, Jansen-Marques, Gabriel, Filgueiras, Igor Salerno, De Vito, Roberta, Freire, Paula Paccielli, de Miranda, Gustavo Cabral, Camara, Niels Olsen Saraiva, Calich, Vera Lúcia Garcia, Ochs, Hans D., Schimke, Lena F., Jurisica, Igor, Condino-Neto, Antonio, and Cabral-Marques, Otavio

Published
2021
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8. Blocking the CTLA-4 and PD-1 pathways during pulmonary paracoccidioidomycosis improves immunity, reduces disease severity, and increases the survival of infected mice.

Author

Willian Preite, Nycolas, Montanari Borges, Bruno, de Lima Kaminski, Valéria, Caçador Ayupe, Marina, Mandu Gonçalves, Leonardo, Vieira dos Santos, Bianca, Fonseca, Dennyson Leandro M., Salerno Filgueiras, Igor, Loureiro Salgado, Caio, Marcia Muxel, Sandra, Cabral-Marques, Otavio, Morais da Fonseca, Denise, Vieira Loures, Flávio, and Garcia Calich, Vera Lúcia

Subjects
PARACOCCIDIOIDOMYCOSIS, CYTOTOXIC T lymphocyte-associated molecule-4, PROGRAMMED cell death 1 receptors, IMMUNE checkpoint proteins, CHRONIC granulomatous disease, T helper cells
Abstract

Immune checkpoint pathways, i.e., coinhibitory pathways expressed as feedback following immune activation, are crucial for controlling an excessive immune response. Cytotoxic T lymphocyte antigen-4 (CTLA-4) and programmed cell death protein-1 (PD-1) are the central classical checkpoint inhibitory (CPI) molecules used for the control of neoplasms and some infectious diseases, including some fungal infections. As the immunosuppression of severe paracoccidioidomycosis (PCM), a chronic granulomatous fungal disease, was shown to be associated with the expression of coinhibitory molecules, we hypothesized that the inhibition of CTLA-4 and PD-1 could have a beneficial effect on pulmonary PCM. To this end, C57BL/6 mice were infected with Paracoccidioides brasiliensis yeasts and treated with monoclonal antibodies (mAbs) α-CTLA-4, α-PD-1, control IgG, or PBS. We verified that blockade of CTLA-4 and PD-1 reduced the fungal load in the lungs and fungal dissemination to the liver and spleen and decreased the size of pulmonary lesions, resulting in increased survival of mice. Compared with PBS-treated infected mice, significantly increased levels of many pro- and anti-inflammatory cytokines were observed in the lungs of α-CTLA-4-treated mice, but a drastic reduction in the liver was observed following PD-1 blockade. In the lungs of α-CPI and IgGtreated mice, there were no changes in the frequency of inflammatory leukocytes, but a significant reduction in the total number of these cells was observed. Compared with PBS-treated controls, α-CPI- and IgG-treated mice exhibited reduced pulmonary infiltration of several myeloid cell subpopulations and decreased expression of costimulatory molecules. In addition, a decreased number of CD4+ and CD8+ T cells but sustained numbers of Th1, Th2, and Th17 T cells were detected. An expressive reduction in several Treg subpopulations and their maturation and suppressive molecules, in addition to reduced numbers of Treg, TCD4+, and TCD8+ cells expressing costimulatory and coinhibitory molecules of immunity, were also detected. The novel cellular and humoral profiles established in the lungs of α-CTLA-4 and α-PD-1-treated mice but not in control IgG-treated mice were more efficient at controlling fungal growth and dissemination without causing increased tissue pathology due to excessive inflammation. This is the first study demonstrating the efficacy of CPI blockade in the treatment of pulmonary PCM, and further studies combining the use of immunotherapy with antifungal drugs are encouraged. [ABSTRACT FROM AUTHOR]

Published
2024
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9. COVID-19 Vaccination and Serological Profile of a Brazilian University Population

Author

Barreto, Marina dos Santos, primary, Silva, Beatriz Soares da, additional, Santos, Ronaldy Santana, additional, Silva, Deise Maria Rego Rodrigues, additional, Silva, Eloia Emanuelly Dias, additional, Moura, Pedro Henrique Macedo, additional, Souza, Jessiane Bispo de, additional, Santana, Lucas Alves da Mota, additional, Fonseca, Dennyson Leandro M., additional, Filgueiras, Igor Salerno, additional, Guimarães, Adriana Gibara, additional, Cabral-Marques, Otavio, additional, Schimke, Lena F., additional, and Borges, Lysandro Pinto, additional

Published
2023
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10. Interferome signature dynamics during the anti-dengue immune response: a systems biology characterization

Author

Usuda, Júlia Nakanishi, primary, Plaça, Desirée Rodrigues, additional, Fonseca, Dennyson Leandro M., additional, Marques, Alexandre H. C., additional, Filgueiras, Igor Salerno, additional, Chaves, Victor Gabriel Bastos, additional, Adri, Anny Silva, additional, Torrentes-Carvalho, Amanda, additional, Hirata, Mario Hiroyuki, additional, Freire, Paula Paccielli, additional, Catar, Rusan, additional, Cabral-Miranda, Gustavo, additional, Schimke, Lena F., additional, Moll, Guido, additional, and Cabral-Marques, Otavio, additional

Published
2023
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11. A higher number of SARS-COV-2 infections in quilombola communities than in the local population in Brazil

Author

Martins, Aline Fagundes, primary, de Souza, Daniela Raguer Valadão, additional, de Rezende Neto, José Melquiades, additional, Santos, Aryanne Araujo, additional, da Invenção, Grazielly Bispo, additional, Matos, Igor Leonardo Santos, additional, dos Santos, Kezia Alves, additional, de Jesus, Pamela Chaves, additional, da Silva, Francilene Amaral, additional, de Almeida, Fernando Henrique Oliveira, additional, do Vale, Fernando Yuri Nery, additional, Fonseca, Dennyson Leandro M., additional, Schimke, Lena F., additional, Matos, Saulo Santos, additional, Oliveira, Brenda Morais, additional, Ferreira, Cyntia Silva, additional, de Paula Dias, Bruna, additional, dos Santos, Samara Mayra Soares Alves, additional, Barbosa, Camila Cavadas, additional, de Carvalho Barreto, Ikaro Daniel, additional, Moreno, Ana Karolina Mendes, additional, Gonçalves, Ricardo Lemes, additional, de Mello Silva, Breno, additional, Cabral-Marques, Otavio, additional, and Borges, Lysandro Pinto, additional

Published
2023
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12. Neuroimmunology of rabies: new insights into an ancient disease

Author

Cabral-Marques, Otavio, primary, Bastos, Victor, additional, Silva, Vinicius Pacheco da, additional, Rodrigues, Érika D. L., additional, Moraes, Cássia N. S., additional, Nóbile, Adriel Leal, additional, Fonseca, Dennyson Leandro M., additional, Souza, Kamilla Batista S., additional, Vale, Fernando Y. N. do, additional, Filgueiras, Igor Salerno, additional, Schimke, Lena F., additional, Giil, Lasse M., additional, Moll, Guido, additional, Cabral-Miranda, Gustavo, additional, Ochs, Hans, additional, Vasconcelos, Pedro Fernando da Costa, additional, Melo, Guilherme Dias de, additional, Bourhy, Hervé, additional, and Casseb, Livia Medeiros Neves, additional

Published
2023
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13. Corrigendum to “Cross-sectional analysis of students and school workers reveals a high number of asymptomatic SARS-CoV-2 infections during school reopening in Brazilian cities” [Heliyon 8 (11) (November 2022) Article e11368]

Author

Borges, Lysandro P., primary, Guimarães, Adriana G., additional, Fonseca, Dennyson Leandro M., additional, Freire, Paula P., additional, Barreto, Íkaro D.C., additional, Souza, Daniela R.V., additional, Gurgel, Ricardo Q., additional, Lopes, Aline S.A., additional, Melquiades de Rezende Neto, José, additional, dos Santos, Kezia A., additional, Matos, Igor L.S., additional, da Invenção, Grazielly B., additional, Oliveira, Brenda M., additional, Santos, Aryanne A., additional, Soares, Daniele Almeida, additional, de Jesus, Pamela C., additional, dos Santos, Cliomar A., additional, Goes, Marco A.O., additional, Plaça, Desirée Rodrigues, additional, Filgueiras, Igor Salerno, additional, Marques, Alexandre H.C., additional, Baiocchi, Gabriela Crispim, additional, CabralMiranda, William, additional, Cabral de Miranda, Gustavo, additional, Saraiva Camara, Niels Olsen, additional, Garcia Calich, Vera Lúcia, additional, Ramos, Rodrigo Nalio, additional, Nakaya, Helder I., additional, Rocha, Vanderson, additional, Giil, Lasse M., additional, Ochs, Hans D., additional, Schimke, Lena F., additional, de Souza, Mércia S.F., additional, Cuevas, Luis E., additional, Martins, Aline F., additional, and Cabral-Marques, Otavio, additional

Published
2023
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14. Neuroimmunology of rabies: New insights into an ancient disease.

Author

Bastos, Victor, Pacheco, Vinicius, Rodrigues, Érika D. L., Moraes, Cássia N. S., Nóbile, Adriel L., Fonseca, Dennyson Leandro M., Souza, Kamilla B. S., do Vale, Fernando Y. N., Filgueiras, Igor S., Schimke, Lena F., Giil, Lasse M., Moll, Guido, Cabral‐Miranda, Gustavo, Ochs, Hans D., Vasconcelos, Pedro F. da Costa, de Melo, Guilherme D., Bourhy, Hervé, Casseb, Livia M. N., and Cabral‐Marques, Otavio

Subjects
RABIES, COVID-19, NEUROIMMUNOLOGY, CORONAVIRUS diseases, ANIMAL populations, CENTRAL nervous system
Abstract

Rabies is an ancient neuroinvasive viral (genus Lyssavirus, family Rhabdoviridae) disease affecting approximately 59,000 people worldwide. The central nervous system (CNS) is targeted, and rabies has a case fatality rate of almost 100% in humans and animals. Rabies is entirely preventable through proper vaccination, and thus, the highest incidence is typically observed in developing countries, mainly in Africa and Asia. However, there are still cases in European countries and the United States. Recently, demographic, increasing income levels, and the coronavirus disease 2019 (COVID‐19) pandemic have caused a massive raising in the animal population, enhancing the need for preventive measures (e.g., vaccination, surveillance, and animal control programs), postexposure prophylaxis, and a better understanding of rabies pathophysiology to identify therapeutic targets, since there is no effective treatment after the onset of clinical manifestations. Here, we review the neuroimmune biology and mechanisms of rabies. Its pathogenesis involves a complex and poorly understood modulation of immune and brain functions associated with metabolic, synaptic, and neuronal impairments, resulting in fatal outcomes without significant histopathological lesions in the CNS. In this context, the neuroimmunological and neurochemical aspects of excitatory/inhibitory signaling (e.g., GABA/glutamate crosstalk) are likely related to the clinical manifestations of rabies infection. Uncovering new links between immunopathological mechanisms and neurochemical imbalance will be essential to identify novel potential therapeutic targets to reduce rabies morbidity and mortality. [ABSTRACT FROM AUTHOR]

Published
2023
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15. Integrative systems immunology uncovers molecular networks of the cell cycle that stratify COVID‐19 severity

Author

Prado, Caroline Aliane de Souza, primary, Fonseca, Dennyson Leandro M., additional, Singh, Youvika, additional, Filgueiras, Igor Salerno, additional, Baiocchi, Gabriela Crispim, additional, Plaça, Desirée Rodrigues, additional, Marques, Alexandre H. C., additional, Dantas‐Komatsu, Raquel Costa Silva, additional, Usuda, Júlia N., additional, Freire, Paula Paccielli, additional, Salgado, Ranieri Coelho, additional, Napoleao, Sarah Maria da Silva, additional, Ramos, Rodrigo Nalio, additional, Rocha, Vanderson, additional, Zhou, Guangyan, additional, Catar, Rusan, additional, Moll, Guido, additional, Camara, Niels Olsen Saraiva, additional, de Miranda, Gustavo Cabral, additional, Calich, Vera Lúcia Garcia, additional, Giil, Lasse M., additional, Mishra, Neha, additional, Tran, Florian, additional, Luchessi, Andre Ducati, additional, Nakaya, Helder I., additional, Ochs, Hans D., additional, Jurisica, Igor, additional, Schimke, Lena F., additional, and Cabral‐Marques, Otavio, additional

Published
2023
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16. SARS-CoV-2 infection induces the production of autoantibodies in severe COVID-19 patients in an age-dependent manner

Author

Fonseca, Dennyson Leandro M, primary, Filgueiras, Igor Salerno, additional, Marques, Alexandre HC, additional, Vojdani, Elroy, additional, Halpert, Gilad, additional, Ostrinski, Yuri, additional, Baiocchi, Gabriela Crispim, additional, Plaça, Desirée Rodrigues, additional, Freire, Paula P., additional, Pour, Shahab Zaki, additional, Moll, Guido, additional, Catar, Rusan, additional, Lavi, Yael Bublil, additional, Silverberg, Jonathan I., additional, Zimmerman, Jason, additional, de Miranda, Gustavo Cabral, additional, Carvalho, Robson F, additional, Khan, Taj Ali, additional, Heidecke, Harald, additional, Dalmolin, Rodrigo JS, additional, Luchessi, Andre Ducati, additional, Ochs, Hans D., additional, Schimke, Lena F., additional, Amital, Howard, additional, Riemekasten, Gabriela, additional, Zyskind, Israel, additional, Rosenberg, Avi Z, additional, Vojdani, Aristo, additional, Shoenfeld, Yehuda, additional, and Cabral-Marques, Otavio, additional

Published
2022
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17. Severe COVID-19 Shares a Common Neutrophil Activation Signature with Other Acute Inflammatory States

Author

Schimke, Lena F., primary, Marques, Alexandre H. C., additional, Baiocchi, Gabriela Crispim, additional, de Souza Prado, Caroline Aliane, additional, Fonseca, Dennyson Leandro M., additional, Freire, Paula Paccielli, additional, Rodrigues Plaça, Desirée, additional, Salerno Filgueiras, Igor, additional, Coelho Salgado, Ranieri, additional, Jansen-Marques, Gabriel, additional, Rocha Oliveira, Antonio Edson, additional, Peron, Jean Pierre Schatzmann, additional, Cabral-Miranda, Gustavo, additional, Barbuto, José Alexandre Marzagão, additional, Camara, Niels Olsen Saraiva, additional, Calich, Vera Lúcia Garcia, additional, Ochs, Hans D., additional, Condino-Neto, Antonio, additional, Overmyer, Katherine A., additional, Coon, Joshua J., additional, Balnis, Joseph, additional, Jaitovich, Ariel, additional, Schulte-Schrepping, Jonas, additional, Ulas, Thomas, additional, Schultze, Joachim L., additional, Nakaya, Helder I., additional, Jurisica, Igor, additional, and Cabral-Marques, Otávio, additional

Published
2022
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18. Autoantibodies linked to autoimmune diseases associate with COVID-19 outcomes

Author

Baiocchi, Gabriela Crispim, primary, Vojdani, Aristo, additional, Rosenberg, Avi Z, additional, Vojdani, Elroy, additional, Halpert, Gilad, additional, Ostrinski, Yuri, additional, Zyskind, Israel, additional, Filgueiras, Igor Salerno, additional, Schimke, Lena F., additional, Marques, Alexandre H. C., additional, Giil, Lasse M., additional, Lavi, Yael Bublil, additional, Silverberg, Jonathan I., additional, Zimmerman, Jason, additional, Hill, Dana Ashley, additional, Thornton, Amanda, additional, Kim, Myungjin, additional, De Vito, Roberta, additional, Fonseca, Dennyson Leandro M., additional, Plaça, Desireé Rodrigues, additional, Freire, Paula Paccielli, additional, Camara, Niels Olsen Saraiva, additional, Calich, Vera Lúcia Garcia, additional, Heidecke, Harald, additional, Lattin, Miriam T., additional, Ochs, Hans D., additional, Riemekasten, Gabriela, additional, Amital, Howard, additional, Cabral-Marques, Otavio, additional, and Shoenfeld, Yehuda, additional

Published
2022
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19. High Number of Asymptomatic SARS-CoV-2 Infection During School Reopening in Brazilian Cities

Author

Borges, Lysandro, primary, Guimarães, Adriana, additional, Souza, Daniela, additional, Gurgel, Ricardo, additional, Lopes, Aline, additional, Barreto, Ikaro, additional, Martins, Aline, additional, Neto, José, additional, Santos, Kezia, additional, Matos, Igor, additional, Invenção, Grazielly, additional, Oliveira, Brenda, additional, Santos, Aryanne, additional, Soares, Daniele, additional, Jesus, Pamela, additional, dos Santos, Cliomar Alves, additional, Góes, Marco Aurélio Oliveira, additional, Plaça, Desiree, additional, Salerno Filgueiras, Igor, additional, Marques, Alexandre, additional, Crispim Baiocchi, Gabriela, additional, Cabral-Miranda, William, additional, Miranda, Gustavo, additional, Camara, Niels O.S., additional, Garcia Calich, Vera Lucia, additional, Ramos, Rodrigo, additional, Nakaya, Helder, additional, Rocha, Vanderson, additional, Giil, Lasse, additional, Ochs, Hans D., additional, Schimke, Lena F., additional, Souza, Mércia, additional, Cuevas, Luiz, additional, Martins, Aline F., additional, Fonseca, Dennyson Leandro M., additional, Paccielli Freire, Paula, additional, and Cabral-Marques, Otavio, additional

Published
2022
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20. COVID‐19 vaccinations: The unknowns, challenges, and hopes

Author

Mohamed, Kawthar, primary, Rzymski, Piotr, additional, Islam, Md Shahidul, additional, Makuku, Rangarirai, additional, Mushtaq, Ayesha, additional, Khan, Amjad, additional, Ivanovska, Mariya, additional, Makka, Sara A., additional, Hashem, Fareeda, additional, Marquez, Leander, additional, Cseprekal, Orsolya, additional, Filgueiras, Igor Salerno, additional, Fonseca, Dennyson Leandro M., additional, Mickael, Essouma, additional, Ling, Irene, additional, Arero, Amanuel Godana, additional, Cuschieri, Sarah, additional, Minakova, Kseniia, additional, Rodríguez‐Román, Eduardo, additional, Abarikwu, Sunny O., additional, Faten, Attig‐Bahar, additional, Grancini, Giulia, additional, Cabral‐Marques, Otavio, additional, and Rezaei, Nima, additional

Published
2021
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21. The network interplay of interferon and toll-like receptor signaling pathways in the anti-Candida immune response

Author

Salgado, Ranieri Coelho, primary, Fonseca, Dennyson Leandro M., additional, Marques, Alexandre H. C., additional, Napoleao, Sarah M. S., additional, Franca, Tabata Takahashi, additional, Akashi, Karen Tiemi, additional, Prado, Caroline A. S., additional, Baiocchi, Gabriela Crispim, additional, Placa, Desiree R., additional, Jansen-Marques, Gabriel, additional, Filgueiras, Igor Salerno, additional, De Vito, Roberta, additional, Freire, Paula Paccielli, additional, de Miranda, Gustavo Cabral, additional, Camara, Niels Olsen Saraiva, additional, Calich, Vera L. G., additional, Ochs, Hans D., additional, Schimke, Lena F., additional, Jurisica, Igor, additional, Condino-Neto, Antonio, additional, and Cabral-Marques, Otavio, additional

Published
2021
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22. The relationship between autoantibodies targeting GPCRs and the renin-angiotensin system associates with COVID-19 severity

Author

Cabral-Marques, Otavio, primary, Halpert, Gilad, additional, Schimke, Lena F., additional, Ostrinski, Yuri, additional, Zyskind, Israel, additional, Lattin, Miriam T., additional, Tran, Florian, additional, Schreiber, Stefan, additional, Marques, Alexandre H.C., additional, Filgueiras, Igor Salerno, additional, Plaça, Desirée Rodrigues, additional, Baiocchi, Gabriela Crispim, additional, Freire, Paula Paccielli, additional, Fonseca, Dennyson Leandro M., additional, Humrich, Jens Y., additional, Lange, Tanja, additional, Müller, Antje, additional, Giil, Lasse M., additional, Graßhoff, Hanna, additional, Schumann, Anja, additional, Hackel, Alexander Maximilian, additional, Junker, Juliane, additional, Meyer, Carlotta, additional, Ochs, Hans D., additional, Lavi, Yael Bublil, additional, Schulze-Forster, Kai, additional, Silvergerg, Jonathan I., additional, Amital, Howard, additional, Zimmerman, Jason, additional, Heidecke, Harry, additional, Rosenberg, Avi Z, additional, Riemekasten, Gabriela, additional, and Shoenfeld, Yehuda, additional

Published
2021
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23. Severe COVID-19 shares a common neutrophil activation signature with other acute inflammatory states

Author

Schimke, Lena F., primary, Marques, Alexandre H.C., additional, Baiocchi, Gabriela Crispim, additional, de Souza Prado, Caroline Aliane, additional, Fonseca, Dennyson Leandro M., additional, Freire, Paula Paccielli, additional, Plaça, Desirée Rodrigues, additional, Filgueiras, Igor Salerno, additional, Salgado, Ranieri Coelho, additional, Jansen-Marques, Gabriel, additional, Oliveira, Antonio Edson Rocha, additional, Peron, Jean Pierre Schatzmann, additional, Cabral-Miranda, Gustavo, additional, Barbuto, José Alexandre Marzagão, additional, Camara, Niels Olsen Saraiva, additional, Calich, Vera Lúcia Garcia, additional, Ochs, Hans D., additional, Condino-Neto, Antonio, additional, Overmyer, Katherine A., additional, Coon, Joshua J., additional, Balnis, Joseph, additional, Jaitovich, Ariel, additional, Schulte-Schrepping, Jonas, additional, Ulas, Thomas, additional, Schultze, Joachim L., additional, Nakaya, Helder I., additional, Jurisica, Igor, additional, and Cabral-Marques, Otávio, additional

Published
2021
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24. Multi-Layered Transcriptomic Holistic Analyses Reveal an Immunological Overlap between COVID-19 and Hemophagocytic Lymphohistiocytosis Associated with Disease Severity

Author

Schimke, Lena F., primary, Marques, Alexandre H.C., additional, Crispim Baiocchi, Gabriela, additional, de Souza Prado, Caroline Aliane, additional, Fonseca, Dennyson Leandro M., additional, Paccielli Freire, Paula, additional, Rodrigues Placa, Desirée, additional, Salerno Filgueiras, Igor, additional, Coelho Salgado, Ranieri, additional, Jansen-Marques, Gabriel, additional, Rocha Oliveira, Antonio Edson, additional, Peron, Jean Pierre Schatzmann, additional, Marzagão Barbuto, Jose Alexandre, additional, Camara, Niels O.S., additional, Garcia Calich, Vera Lucia, additional, Ochs, Hans D., additional, Condino-Neto, Antonio, additional, Overmyer, Katherine A., additional, Coon, Joshua J., additional, Balnis, Joseph, additional, Jaitovich, Ariel, additional, Schulte-Schrepping, Jonas, additional, Ulas, Thomas, additional, Schultze, Joachim L., additional, Nakaya, Helder, additional, Jurisica, Igor, additional, and Cabral-Marques, Otavio, additional

Published
2021
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25. Specific immune-regulatory transcriptional signatures reveal sex and age differences in SARS-CoV-2 infected patients

Author

Freire, Paula Paccielli, primary, Marques, Alexandre H. C., additional, Baiocchi, Gabriela Crispim, additional, Schimke, Lena F., additional, Fonseca, Dennyson Leandro M., additional, Salgado, Ranieri Coelho, additional, Filgueiras, Igor Salerno, additional, da Silva Napoleao, Sarah Maria, additional, Plaça, Desirée Rodrigues, additional, Hirata, Thiago Dominguez Crespo, additional, El Khawanky, Nadia, additional, Giil, Lasse Melvaer, additional, de Miranda, Gustavo Cabral, additional, Carvalho, Robson Francisco, additional, de Souza Ferreira, Luis Carlos, additional, Condino-Neto, Antonio, additional, Nakaya, Helder Takashi Imoto, additional, Jurisica, Igor, additional, Ochs, Hans D., additional, Camara, Niels Olsen Saraiva, additional, Calich, Vera Lúcia Garcia, additional, and Cabral-Marques, Otavio, additional

Published
2020
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26. COVID‐19 vaccinations: The unknowns, challenges, and hopes.

Author

Mohamed, Kawthar, Rzymski, Piotr, Islam, Md Shahidul, Makuku, Rangarirai, Mushtaq, Ayesha, Khan, Amjad, Ivanovska, Mariya, Makka, Sara A., Hashem, Fareeda, Marquez, Leander, Cseprekal, Orsolya, Filgueiras, Igor Salerno, Fonseca, Dennyson Leandro M., Mickael, Essouma, Ling, Irene, Arero, Amanuel Godana, Cuschieri, Sarah, Minakova, Kseniia, Rodríguez‐Román, Eduardo, and Abarikwu, Sunny O.

Subjects
SARS-CoV-2, COVID-19 vaccines, COVID-19, VACCINATION
Abstract

The entire world has been suffering from the coronavirus disease 2019 (COVID‐19) pandemic since March 11, 2020. More than a year later, the COVID‐19 vaccination brought hope to control this viral pandemic. Here, we review the unknowns of the COVID‐19 vaccination, such as its longevity, asymptomatic spread, long‐term side effects, and its efficacy on immunocompromised patients. In addition, we discuss challenges associated with the COVID‐19 vaccination, such as the global access and distribution of vaccine doses, adherence to hygiene guidelines after vaccination, the emergence of novel severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) variants, and vaccine resistance. Despite all these challenges and the fact that the end of the COVID‐19 pandemic is still unclear, vaccines have brought great hope for the world, with several reports indicating a significant decline in the risk of COVID19‐related infection and hospitalizations. Highlights: 1.Vaccination plays a pivotal role in reducing the death toll of the COVID‐19 infection.2.The immunity provided by vaccines is still disputable leading to some challenges like the asymptomatic spread; therefore, staying strict to hygiene guidelines is necessary.3.Hence, COVID‐19 vaccines' related long‐term side effects are still unknown; cautions should be taken when injected to various individuals of the community.4.COVID‐19 vaccines' effectiveness are strongly related to their effect on emergent COVID‐19 variants, but until now approved vaccines can still show some protective effects against new variants. [ABSTRACT FROM AUTHOR]

Published
2022
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27. Integrative systems neuroimmunology reveals leukocyte-expressing PAX6 as a critical predictor of major depressive disorder.

Author

Dias HD, Adri AS, Nóbile AL, de Oliveira MG, Chung EN, Bahia IAF, Fonseca DLM, Schimke LF, Filgueiras IS, Marçal P, Nery do Vale FY, Dalmolin RJS, Cabral-Miranda G, Nakaya H, Bortoloti R, Hamani C, Wheeler MA, Rezende RM, and Cabral-Marques O

Abstract

Major depressive disorder (MDD) is a complex psychiatric condition with a significant global impact. This study applied a genomic-driven integrative systems neuroimmunology approach to analyze transcriptomic data from 3,114 individuals (1,877 MDD patients and 1,237 controls). The analysis revealed neuroimmunological transcriptomic alterations, indicating cross-talk between the immune and nervous systems in peripheral blood mononuclear cells (PBMCs) and specific brain regions. Among 31 shared genes, NEGR1, PPP6C, SORCS3, and PAX6 emerged as significant predictors of MDD in patients' PBMCs. Notably, PAX6 was also identified as a differentially expressed gene (DEG) in the amygdala, while NEGR1, PPP6C, and SORCS3 showed no significant differential expression in other central nervous system (CNS) regions. Validation by immunophenotyping in a mouse model of chronic stress demonstrated increased PAX6 expression in PBMCs, a gene previously associated with MDD in GWAS studies. Collectively, our findings suggest the existence of shared transcriptomic modules across the brain and immune system, highlighting PAX6 as a potential therapeutic target in MDD.

Published
2024
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28. The Global Evolution and Impact of Systems Biology and Artificial Intelligence in Stem Cell Research and Therapeutics Development: A Scoping Review.

Author

Silva-Sousa T, Usuda JN, Al-Arawe N, Frias F, Hinterseher I, Catar R, Luecht C, Riesner K, Hackel A, Schimke LF, Dias HD, Filgueiras IS, Nakaya HI, Camara NOS, Fischer S, Riemekasten G, Ringdén O, Penack O, Winkler T, Duda G, Fonseca DLM, Cabral-Marques O, and Moll G

Abstract

Advanced bioinformatics analysis, such as systems biology (SysBio) and artificial intelligence (AI) approaches, including machine learning (ML) and deep learning (DL), is increasingly present in stem cell (SC) research. An approximate timeline on these developments and their global impact is still lacking. We conducted a scoping review on the contribution of SysBio and AI analysis to SC research and therapy development based on literature published in PubMed between 2000 and 2024. We identified an 8-10-fold increase in research output related to all three search terms between 2000 and 2021, with a 10-fold increase in AI-related production since 2010. Use of SysBio and AI still predominates in preclinical basic research with increasing use in clinically oriented translational medicine since 2010. SysBio- and AI-related research was found all over the globe, with SysBio output led by the United States (US, n=1487), United Kingdom (UK, n=1094), Germany (n=355), The Netherlands (n=339), Russia (n=215), and France (n=149), while for AI-related research the US (n=853) and UK (n=258) take a strong lead, followed by Switzerland (n=69), The Netherlands (n=37), and Germany (n=19). The US and UK are most active in SCs publications related to AI/ML and AI/DL. The prominent use of SysBio in ESC research was recently overtaken by prominent use of AI in iPSC and MSC research. This study reveals the global evolution and growing intersection between AI, SysBio, and SC research over the past two decades, with substantial growth in all three fields and exponential increases in AI-related research in the past decade., (© The Author(s) 2024. Published by Oxford University Press. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.)

Published
2024
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