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2. Proceedings of the Survivorship Care in Neuro-Oncology Workshop sponsored by the Comprehensive Oncology Network Evaluating Rare CNS Tumors (NCI-CONNECT).

Author

Leeper, Heather E, Tonorezos, Emily, Mayer, Deborah, Bakitas, Marie, Chang, Susan, Cooley, Mary E, Hervey-Jumper, Shawn, Miaskowski, Christine, Sherwood, Paula, Tsien, Christina, Wallgren, Kimberly, Willmarth, Nicole, Arons, David, Acquaye, Alvina, King, Amanda L, Penas-Prado, Marta, Vera, Elizabeth, Gilbert, Mark R, Armstrong, Terri S, Arzbaecher, Jean, Dionne-Odom, J Nicholas, Fink, Karen, Hayes, Christi, Leeper, Heather, Lollo, Nicole, Loughan, Ashlee, Oliver, Kathy, Roche, Kayla, Stearn, Sylvia, Timmer, Michael, Amidei, Christina, Blakeley, Jaishri, Cachia, David, Cooke, Laura, Cooley, Mary, Gondi, Vinai, Leach, Danielle, Mendoza, Tito, Morgan, Kendall, Nabors, Burt, Naines, Kristie, Rogers, James, Sharma, Akanksha, Wall, Kathleen, Weathers, Shiao-Pei, Wollet, Alex, Boccia, Maria, Camphausen, Kevin, Christ, Alexa, Figuracion, Karl Cristie, Gilbert, Mark, Komlodi-Pasztor, Edina, Lieberman, Frank, Malkin, Mark, Miller, Hope, Paleologos, Nina, Panzer, Marissa, Stout, Nicole, Wen, Patrick, Beam, Sarah, Boris, Lisa, Fonkem, Ekokobe, Jammula, Varna, Kauss, McKenzie, Kim, Yeonju, Ozer, Byram H, Pan, Edward, Pugh, Stephanie, Strowd, Roy, Wu, Jing, Zaghloul, Kareem, Bell, Susan, Dunbar, Erin M, Haynes, Chas, Haynes, Tuesday, Lesser, Glenn, Maher, Molly, Polskin, Lily, and Pillai, Tina

Subjects
Cancer, Clinical Research, Neurosciences, Management of diseases and conditions, 7.1 Individual care needs, Good Health and Well Being, NCI-CONNECT, patient-centered care, primary central nervous system cancer, survivorship, survivorship care, NCI-CONNECT Survivorship Care in Neuro-Oncology Workshop
Abstract

BackgroundSurvivorship for those living with primary CNS cancers begins at diagnosis, continues throughout a person's life, and includes caregivers. Opportunities and challenges exist to advance survivorship care for those living with primary CNS cancers that necessitate stakeholder involvement.MethodsIn June 2021, NCI-CONNECT convened a two-day virtual workshop about survivorship care in neuro-oncology. Two expert panels provided key recommendations and five working groups considered critical questions to identify strengths, weaknesses, opportunities, and threats to the advancement of survivorship care and developed recommendations and action items.ResultsThe following action items emanated from the workshop: seek endorsement of meeting report from stakeholder organizations; address barriers in access to survivorship care and provider reimbursement; advance survivorship research through NIH and private grant support; develop a survivorship tool kit for providers, people living with primary CNS cancers and their caregivers; provide accessible educational content for neuro-oncology, neurology, and oncology community providers about survivorship care in neuro-oncology; and establish core competencies for survivorship care for neuro-oncology providers to be included in training and standardized exams.ConclusionsAction items aim to address access and reimbursement barriers, expand patient and provider education, develop core competencies, and support survivorship research through funding and other supports.

Published
2022

9. Contributors

Author

Baehring, Joachim M., primary, Bastos, Dhiego C.A., additional, Beegle, Richard, additional, Bi, Wenya Linda, additional, Blackburn, Kyle M., additional, Blumenthal, Deborah T., additional, Bourekas, Eric C., additional, Bovi, Joseph A., additional, Brennan, Nicole Petrovich, additional, Brown, Alyssa, additional, Budhu, Joshua A., additional, Burt Nabors, L., additional, Bussiere, Marc, additional, Chakravarti, Arnab, additional, Chamberlain, Marc C., additional, Chao, Samuel T., additional, Chapman, Paul H., additional, Chen, Clark C., additional, Chi, Susan, additional, Choi, Serah, additional, Christoforidis, Gregory A., additional, Clarke, Jennifer L., additional, Corrêa, Diogo Goulart, additional, da Cruz, Luiz Celso Hygino, additional, Diaz, Maria, additional, Dixit, Karan S., additional, Dodson, Sean, additional, Edwards, Ryan M., additional, Ellika, Shehanaz, additional, Ellithi, Moataz, additional, Elsamadicy, Aladine A., additional, Fecci, Peter E., additional, Ferrante, Mark A., additional, Ferraro, Nicholas C., additional, Field, Melvin, additional, Fisicaro, Ryan, additional, Fonkem, Ekokobe, additional, Fulbright, Robert K., additional, Gerstner, Elizabeth R., additional, Golby, Alexandra J., additional, Goulart, Carlos R., additional, Guenette, Jeffrey P., additional, Guiou, Michael, additional, Gupta, Nilendu, additional, Halima, Ahmed, additional, Hatef, Angel L., additional, Heverhagen, Johannes T., additional, Holodny, Andrei, additional, Hughes, Tudor Hesketh, additional, Huie, David, additional, Ilica, Ahmet Turan, additional, Ina Ly, K., additional, Ivan, Michael E., additional, Jain, Rajan, additional, Johansson, Jens, additional, Johnson, Michele H., additional, Jolesz, Ferenc A., additional, Jung, Edward W., additional, Kangarlu, Alayar, additional, Kardan, Arash, additional, Karschnia, Philipp, additional, Kaur, Gurvinder, additional, Kijewski, Marie Foley, additional, Kim, Jinsuh, additional, Kocher, Madison, additional, Komotar, Ricardo J., additional, Krol, George, additional, Kurz, Sylvia C., additional, Kwofie, Michael, additional, Lantos, Joshua, additional, Lee, Eudocia Quant, additional, Le Rhun, Emilie, additional, Lerner, Emily C., additional, Liu, Benjamin P., additional, Lo, Simon S., additional, Lobbous, Mina, additional, Loeffler, Jay S., additional, Lowe, Stephen R., additional, Luther, Evan, additional, Maier, Stephan E., additional, Majithia, Lonika, additional, Makary, Mina S., additional, Mattei, Tobias A., additional, Mayo, Zachary S., additional, Mendel, Ehud, additional, Mikkelsen, Tom, additional, Miranda, Pedro C., additional, Moffat, Bradford A., additional, Murphy, Erin S., additional, Murray, John Vincent, additional, Muzic, Raymond F., additional, Nagpal, Prashant, additional, Naidich, Michelle J., additional, Newton, Herbert B., additional, Nine, Erik B., additional, Nisnboym, Michal, additional, Noujaim, Daniel, additional, Oberheim Bush, Nancy Ann, additional, Olubiyi, Olutayo, additional, Omay, Sacit Bulent, additional, Paleologos, Nina A., additional, Patel, Kunal S., additional, Pena Pino, Isabela, additional, Poussaint, Tina Young, additional, Prabhu, Sanjay P., additional, Qin, Lei, additional, Qu, Jinrong, additional, Rebeiz, Karim, additional, Reddy, Haricharan, additional, Reeves, Benjamin C., additional, Rogers, Lisa R., additional, Satter, Martin, additional, Sattur, Mithun G., additional, Schmainda, Kathleen M., additional, Shams, Mana, additional, Shams, Sara, additional, Silvera, V. Michelle, additional, Sloan, Andrew, additional, Slone, H. Wayne, additional, Snyder, James, additional, Sodickson, Daniel K., additional, Sodickson, Aaron D., additional, Solnes, Lilja Bjork, additional, Spampinato, Maria Vittoria, additional, Srinivasan, Ethan S., additional, Suh, John H., additional, Sun, Yanping, additional, Sutton, Nicholas A., additional, Tadipatri, Ramya, additional, Tharin, Suzanne, additional, Thompson, Ryan, additional, Turner, Tia H., additional, Vaios, Eugene J., additional, Vernino, Steven, additional, Vogelbaum, Michael A., additional, Walston, Steve, additional, Waltz, Jeffrey, additional, Weicker, Michael A., additional, Welling, D. Bradley, additional, Wen, Patrick Y., additional, Wenger, Cornelia, additional, Wintermark, Max, additional, Wong, Eric T., additional, Yang, Edward, additional, Yeh, Randy, additional, Yildirim, Onur, additional, Young, Geoffrey S., additional, Young, Robert J., additional, Zaman, Rujman U., additional, and Zukas, Alicia M., additional

Published
2022
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16. DISP-09. HISTOPATHOLOGIC AND MOLECULAR PROFILE OF GLIOMAS: A 9-YEAR RETROSPECTIVE STUDY OF CASES DIAGNOSED IN LAGOS NIGERIA

Author

Odukoya, Lateef, primary, Kollmeyer, Thomas, additional, Eckel-Passow, Jeanette, additional, Ida, Cristine, additional, Lachance, Daniel, additional, Fonkem, Ekokobe, additional, Badmos, Kabir, additional, Bankole, Olufemi, additional, Kitange, Gaspar, additional, Daramola, Adetola, additional, Anunobi, Charles, additional, and Jenkins, Robert, additional

Published
2023
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17. GLIOMA-02 HISTOPATHOLOGIC AND MOLECULAR PROFILE OF GLIOMAS: A 9-YEAR RETROSPECTIVE STUDY OF CASES DIAGNOSED IN LAGOS NIGERIA

Author

Odukoya, Lateef, primary, Kollmeyer, Thomas, additional, Eckel-Passow, Jeanette, additional, Ida, Cristiane, additional, Lachance, Daniel, additional, Fonkem, Ekokobe, additional, Badmos, Kabir, additional, Bankole, Olufemi, additional, Kitange, Gaspar, additional, Daramola, Adetola, additional, Anunobi, Charles, additional, and Jenkins, Robert, additional

Published
2023
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18. OTHER-04 FEASIBILITY STUDY ON BRAIN TUMOR BIOBANKING AND REGISTRY IN SUB-SAHARAN AFRICAN COUNTRIES: A QUESTIONNAIRE-BASED SURVEY

Author

Odukoya, Lateef, primary, Kamson, David, additional, Eckel-Passow, Jeanette, additional, Ghomsi, Nathalie, additional, Jenkins, Robert, additional, Balogun, James, additional, Lachance, Daniel, additional, Karekezi, Claire, additional, Ekhator, Chukwuyem, additional, Osei-Tutu, Lawrence, additional, Ngaiza, Advera, additional, Tiamiyu, Liadi, additional, Mwakimonga, Angela, additional, Huse, Jason, additional, Nyalundja, Arsene, additional, Totimeh, Teddy, additional, Badmos, Kabir, additional, Bankole, Olufemi, additional, Kitange, Gaspar, additional, Brown, Desmond, additional, Anunobi, Charles, additional, Schroeder, Kristin, additional, Fonkem, Ekokobe, additional, Cheserem, Beverly, additional, and Zerd, Francis, additional

Published
2023
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22. An expanded safety/feasibility study of the EMulate Therapeutics Voyager™ System in patients with recurrent glioblastoma

Author

Barkhoudarian, Garni, primary, Badruddoja, Michael, additional, Blondin, Nicholas, additional, Chowdhary, Sajeel, additional, Cobbs, Charles, additional, Duic, Julius Paul, additional, Flores, John Paul, additional, Fonkem, Ekokobe, additional, McClay, Edward, additional, Nabors, Louis Burt, additional, Salacz, Michael, additional, Taylor, Lynn, additional, Vaillant, Brian, additional, Gill, Jaya, additional, and Kesari, Santosh, additional

Published
2023
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23. METABOLIC PATHWAYS

Author

Blough, Michael, Al-Najjar, Mohammad, Stechishin, Owen, Ronen, Sabrina, Weiss, Samuel, Luchman, H, Cairncross, J, Fonkem, Ekokobe, Tobin, Richard, Griffin, Jennifer, Zuzek, Alex, Rogers, Martha, Kathagen, Annegret, Schulte, Alexander, Balcke, Gerd, Phillips, Heidi, Günther, Hauke, Westphal, Manfred, Lamszus, Katrin, Fack, Fred, Bonnel, David, Hochart, Guillaume, Navis, Anna, Wesseling, Pieter, Leenders, William, Stauber, Jonathan, Niclou, Simone, Sahm, Felix, Oezen, Iris, Opitz, Christiane, Radlwimmer, Bernhard, von Deimling, Andreas, Bode, Helge, Ahrendt, Tilman, Adams, Seray, Guillemin, Gilles, Wick, Wolfgang, Platten, Michael, Vartanian, Alenoush, Singh, Sanjay, Burrell, Kelly, Agnihotri, Sameer, Sabha, Nesrin, Zadeh, Gelareh, Teo, Charles, McDonald, Kerrie, Zinger, Anna, Bustamante, Sonia, Lim, Chai, Braidy, Nady, Brew, Bruce, Wolf, Amparo, Lang, Fredrick, Verhaak, Roel, Hawkins, Cynthia, Aldape, Kenneth, Chesnelong, Charles, and Chaumeil, Myriam

Abstract

The kynurenine pathway (KP) is the principal route of L-Tryptophan (TRP) catabolism leading to the production of kynurenine (KYN), the neuroprotectants, kynurenic acid (KYNA) and picolinic acid (PIC), and the excitotoxic neurotoxin, quinolinic acid (QUIN). The enzymes indoleamine 2,3-dioxygenase-1 (IDO-1), indoleamine 2, 3-dioxygenase-2 (IDO-2) and tryptophan 2,3-dioxygenase (TDO-2) initiate the first step of the KP. Downstream enzymes include kynureninase (KYNU), 3-hydroxyanthranilate 3,4-dioxygenase (3-HAAO), kynurenine hydroxylase (KMO) and 2-amino-3-carboxymuconate semialdehyde decarboxylase (ACMSD). Kynurenine aminotransferase-I (KAT-I) is one of the enzymes responsible for synthesising KYNA. Mounting evidence directly implicates that IDO-1 induction in various tumours is a crucial mechanism facilitating tumour immune evasion and persistence. However, the involvement of the downstream machinery of the KP in brain tumour progression remains unexplored. A complete characterisation of the KP in brain tumours and the role of the KP in maintaining homeostasis between neuroprotection and neurodegeneration in glioma has not yet been investigated. Here we report the first comprehensive characterisation of the KP in cultured human glioma cells and GBM patient plasma. Our qRT-PCR data revealed that interferon-gamma (IFN-γ) (100 IU/ml) stimulation significantly potentiated the expression of IDO-1 IDO-2, KYNU, 3-HAAO, KMO and significantly down-regulated ACMSD and KAT-I expression in cultured human glioma cells. HPLC analysis revealed that IFN-γ stimulation significantly increased KP activity (KYN/TRP ratio), and significantly lowered the KYNA/KYN neuroprotective ratio in human cultured glioma cells. Our HPLC and GCMS data revealed that KP activation was significantly higher and the concentrations of TRP, KYNA, QUIN and PIC and the KYNA/KYN ratio were significantly lower in GBM patient plasma (n = 18) compared to controls. These results provide further evidence for the involvement of the KP in glioma pathophysiology and highlights a potential role of KP products as novel and highly attractive therapeutic targets to evaluate for the treatment of brain tumours.

Published
2013

27. Molecular Diagnostics and Pathology of Major Brain Tumors

Author

Y. Shan, Frank, primary, Castro, E., additional, Sybenga, Amelia, additional, Mukherjee, Sanjib, additional, Wu, Erxi, additional, Fung, Karming, additional, Li, The, additional, Fonkem, Ekokobe, additional, H. Huang, Jason, additional, and Rao, A., additional

Published
2019
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42. BIOM-43. THE GENOMIC, TRANSCRIPTOMIC, AND EPIGENOMIC LANDSCAPE OF ISOCITRATE DEHYDROGENASE WILD TYPE GLIOBLASTOMA ACROSS THE AGE CONTINUUM

Author

Johnson, Margaret, primary, Bell, April, additional, Shah, Yajas, additional, Viets-Layng, Kayla, additional, Mauer, Elizabeth, additional, Xiu, Joanne, additional, Elemento, Olivier, additional, Glantz, Michael, additional, Walker, Phillip, additional, Chen, Clark, additional, Dunbar, Erin, additional, Fonkem, Ekokobe, additional, Kesari, Santosh, additional, Brenner, Andrew, additional, Newton, Herbert, additional, Low, Justin, additional, Sumrall, Ashley, additional, Korn, Wolfgang, additional, Ashley, David, additional, and Wainwright, Derek, additional

Published
2022
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48. The Texas Immuno-Oncology Biorepository, a statewide biospecimen collection and clinical informatics system to enable longitudinal tumor and immune profiling

Author

Kelly, Ronan J., primary, Whitsett, Timothy G., additional, Snipes, G. Jackson, additional, Dobin, Sheila M., additional, Finholt, Jennifer, additional, Settele, Natalie, additional, Priest, Elisa L., additional, Youens, Kenneth, additional, Wallace, Lucy B., additional, Schwartz, Gary, additional, Wong, Lucas, additional, Henderson, Sherronda M., additional, Gowan, Alan C., additional, Fonkem, Ekokobe, additional, Juarez, Maria I., additional, Murray, Christal E., additional, Wu, Jeffrey, additional, Van Keuren-Jensen, Kendall, additional, Pirrotte, Patrick, additional, Highlander, Sarah, additional, Contente, Tania, additional, Baker, Angela, additional, Victorino, Jose, additional, and Berens, Michael E., additional

Published
2022
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